A 3D animation of mismatch repair in E. coli

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ความคิดเห็น • 142

  • @Gamelover882
    @Gamelover882 ปีที่แล้ว +19

    My professor recommended this video and I see why. It's quick, in plain English, well animated and accurate without over complicating things. Thank you!

  • @DendyJungle
    @DendyJungle 7 ปีที่แล้ว +95

    dont know why you are giving this away for free but i am glad you are. Usually have to pay for really good educational videos

    • @faig4289
      @faig4289 5 ปีที่แล้ว +14

      Shut up

    • @ej_stories
      @ej_stories 3 ปีที่แล้ว

      @@faig4289 😂😂😂

    • @factualbiology7769
      @factualbiology7769 2 ปีที่แล้ว

      th-cam.com/video/iO32xJF1cTk/w-d-xo.html

  • @samarrowsmith1396
    @samarrowsmith1396  6 ปีที่แล้ว +105

    If anyone enjoyed this video and would like to see another of the sort, please suggest your ideas! I'm looking for suggestions for the next topic to animate!

    • @axellir
      @axellir 6 ปีที่แล้ว +3

      The video really helped me to visualize the process! Thanks! How about an animation about homologous recombination?

    • @holden2966
      @holden2966 5 ปีที่แล้ว

      DNA techniques ?

    • @blandon93
      @blandon93 5 ปีที่แล้ว

      How dna polymerase select nucleotudes in replication. Does it take nucleotides freely or they stick?

    • @singhmilandip
      @singhmilandip 5 ปีที่แล้ว +3

      I would like to see SOS response...

    • @srikantadash4603
      @srikantadash4603 4 ปีที่แล้ว

      Transcription Translation post translational modification

  • @hoshi1599
    @hoshi1599 2 ปีที่แล้ว +5

    Beautiful. I didn't realise there was going to be a bend with mutH while studying. This clears up so much .

  • @truth2power528
    @truth2power528 6 ปีที่แล้ว +14

    Great video Sam. This helps tremendously in visualizing the process and makes it easier to understand.

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว +1

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @peednas711
    @peednas711 หลายเดือนก่อน

    Bro I have a professor in molecular cell biology. He's been a professor there for 10-15 years. And still, you were able to explain this mechanism better than him. Good job to you. This is your calling

  • @holden2966
    @holden2966 5 ปีที่แล้ว +11

    Wow! This great! Made perfect sense in just 3 minutes. Great animation! Keep it up Sam

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @holden2966
      @holden2966 3 ปีที่แล้ว

      @@samarrowsmith1396 I just searched it up

  • @johnhenry4389
    @johnhenry4389 8 ปีที่แล้ว +7

    That was one of the best videos of DNA-enzyme interaction I've seen.

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว +2

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @parth2615
      @parth2615 3 ปีที่แล้ว

      @@samarrowsmith1396 I was studying for my molecular genetics course, I couldn't visualize the mismatch repair system so I searched "DNA mismatch repair" on youtube. This was the second recommendation.
      PS. It's a great video. I recently learned the basics of blender, I will also try making such nice little animations just for fun.
      Hope this was helpful.

    • @factualbiology7769
      @factualbiology7769 2 ปีที่แล้ว

      th-cam.com/video/iO32xJF1cTk/w-d-xo.html

    • @Ragunath21
      @Ragunath21 2 หลายเดือนก่อน

      ​@@parth2615 now it's first in recommendation

  • @trudyandgeorge
    @trudyandgeorge ปีที่แล้ว +1

    Went looking for explanations on cyclical redundancy checks and wound up here. So Mother Nature did it first! Bravo 👏

  • @sliceofnoob2885
    @sliceofnoob2885 3 ปีที่แล้ว +1

    Thanks the best vid I've found on mismatch repair....a real life saver

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @hafsaamzim1901
    @hafsaamzim1901 2 ปีที่แล้ว +1

    It’s amazing and very clear. Thank you a lot.

  • @carlosalbertolararojas3610
    @carlosalbertolararojas3610 3 ปีที่แล้ว

    Thank you for this video I was trying to study methods of DNA respiration and I could not visualize this in my mind , you made it a lot easier for me many thanks.

  • @pulgimole5
    @pulgimole5 8 ปีที่แล้ว +6

    Very helpful! thank you

  • @theeducationtree8272
    @theeducationtree8272 5 ปีที่แล้ว +1

    AMAZING!! THANK YOU.

  • @nikitamaurya6644
    @nikitamaurya6644 6 ปีที่แล้ว +2

    Thank you so much,it helped me a lot.

  • @noorulhassankhan
    @noorulhassankhan 3 ปีที่แล้ว

    Wonderful video, thank you so much!

  • @satabdideka8832
    @satabdideka8832 2 หลายเดือนก่อน

    Ahh, you made it so easy! Thanks a lot

  • @Lillith9008
    @Lillith9008 3 ปีที่แล้ว

    This is one of the most aesthetically narrated biology videos I have seen. Thank you :D

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @factualbiology7769
      @factualbiology7769 2 ปีที่แล้ว

      th-cam.com/video/iO32xJF1cTk/w-d-xo.html

  • @a.i892
    @a.i892 3 ปีที่แล้ว

    One of the best educational videos i've ever seen

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @adityakale6064
    @adityakale6064 4 หลายเดือนก่อน

    It was so simple to understand and you saved me for my exams

  • @maryamsediqi3726
    @maryamsediqi3726 ปีที่แล้ว

    Awesome, thank you so much

  • @shivamverma2754
    @shivamverma2754 2 ปีที่แล้ว

    wow so much wow ... great job Sam

  • @harvey2733
    @harvey2733 3 ปีที่แล้ว

    Such an amazing presentation. Loved it.

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @musicspeaks0101
    @musicspeaks0101 6 ปีที่แล้ว +1

    thank you so much!!!

  • @litchfirmian7562
    @litchfirmian7562 2 ปีที่แล้ว

    This is really helpful, thank you, sir.

  • @DL551997
    @DL551997 7 ปีที่แล้ว +2

    extremely helpful. thank you very much!

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @wealllovelina
    @wealllovelina 3 ปีที่แล้ว

    awesome animation! thanks!

  • @Mk-hc9jm
    @Mk-hc9jm 3 ปีที่แล้ว

    Legend, thank you so much

  • @hayilee9601
    @hayilee9601 2 ปีที่แล้ว

    you just saved me! thank you so much :)

  • @ayeshaqamar5972
    @ayeshaqamar5972 4 ปีที่แล้ว

    Thank you so much for the video

  • @twisampatidas9965
    @twisampatidas9965 4 หลายเดือนก่อน

    Awesome brother

  • @aisheebhattacharya4228
    @aisheebhattacharya4228 5 ปีที่แล้ว +1

    Wht abt uvrD helicase?

  • @reviewsbymithy8532
    @reviewsbymithy8532 3 ปีที่แล้ว

    Question please
    Why Dna is looped out in search of nearest d(GATC) methylation site?

  • @ubaldogennaromastrominico786
    @ubaldogennaromastrominico786 2 ปีที่แล้ว

    Great job!

  • @feliscatus4921
    @feliscatus4921 2 ปีที่แล้ว

    this is an informative and useful video!

  • @wasifullahdawar6962
    @wasifullahdawar6962 3 ปีที่แล้ว

    Thank you

  • @lisarichards3217
    @lisarichards3217 7 ปีที่แล้ว +2

    More science videos! This is well done.

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @blancaparraga3006
    @blancaparraga3006 3 ปีที่แล้ว

    Thank you so much

  • @Ssalma6338
    @Ssalma6338 10 หลายเดือนก่อน

    About the DNA polymerase , is it polymerase III which is responsible for the resynthesise of the new strand or the Polymerse I ? I get confused

  • @lapetiteloutre9345
    @lapetiteloutre9345 5 ปีที่แล้ว +1

    Great video, thanks a lot :)

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @user-hq8mx7mn3u
    @user-hq8mx7mn3u 6 ปีที่แล้ว

    Infinitely helpful

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @atanasatanasov9036
    @atanasatanasov9036 7 ปีที่แล้ว

    Awesome! Thanks

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @saja4887
    @saja4887 4 ปีที่แล้ว

    Thanks a lot :)

  • @shafiamobasheri830
    @shafiamobasheri830 3 ปีที่แล้ว

    The best ever

  • @nitukharsel3625
    @nitukharsel3625 ปีที่แล้ว

    A well animated vdo 😊. I liked it very much .please animate mor topics of Molecular biology😢

  • @kalpanamurmu3776
    @kalpanamurmu3776 5 ปีที่แล้ว

    Thanks you sir .

  • @user-de3qh4os7s
    @user-de3qh4os7s 7 ปีที่แล้ว +1

    thank you...... please how can download this video

    • @Ahnzhie
      @Ahnzhie 7 ปีที่แล้ว

      1. Go to www.keepvid.site/
      2. Copy the link of this video and paste it on keepvid site
      3. Click download and you can find more options down :)

  • @arvindshankar7679
    @arvindshankar7679 5 ปีที่แล้ว +1

    Good work fam, this is helpful.

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @ryanisber2353
    @ryanisber2353 2 ปีที่แล้ว

    So good

  • @niharikagovindjha8919
    @niharikagovindjha8919 6 ปีที่แล้ว +2

    it's really good but a bit more clarity about methylation and also references to RecJ and endonuclease VII would have been great

  • @richachawla7931
    @richachawla7931 7 ปีที่แล้ว +1

    Amazing

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @ej_stories
    @ej_stories 3 ปีที่แล้ว

    👌👌👌

  • @matthewgrammatico8434
    @matthewgrammatico8434 7 ปีที่แล้ว +1

    thanks mate. great video!

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @matthewgrammatico8434
      @matthewgrammatico8434 3 ปีที่แล้ว

      I was doing a genetics module at the university of Nottingham and just searched mismatch repair on TH-cam. It's a great video because of the visual aspect.

  • @corvette724
    @corvette724 4 ปีที่แล้ว

    well done Blender job

  • @maheenejaz360
    @maheenejaz360 5 ปีที่แล้ว

    Kindly tell mismatch repair of e. Coli and eukaryotes differs? Pls answer as soon as possible.

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Hi Maheen, I realise this is a VERY late reply on my part so I can only apologise. I imagine my hesitation to answer this question is because I don't fully know the answer myself. There are analogues of the mismatch proteins across life, but the difficulty comes of looking at things within the chromatin environment. Making an accurate animation of the movement of histones and unzipping the DNA strands that have been exposed would be a comparative nightmare (for me anyway, there are probably skilled animators who could try making a representation of this). The wikipedia article for mismatch repair has a basic outline of the analogues: en.wikipedia.org/wiki/DNA_mismatch_repair

  • @malekmohamad4815
    @malekmohamad4815 2 ปีที่แล้ว

    that was epic..my regards from syria

  • @asifhamid9676
    @asifhamid9676 6 ปีที่แล้ว +1

    Superb.....

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @zuhaltatar935
    @zuhaltatar935 5 ปีที่แล้ว +2

    İts very helpfull! Thank you so much :)

    • @SURESHKUMAR-gt7eo
      @SURESHKUMAR-gt7eo 4 ปีที่แล้ว

      Hello

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @elnazzeinali3240
    @elnazzeinali3240 ปีที่แล้ว

    Thats good tnx

  • @zaynas2100
    @zaynas2100 7 ปีที่แล้ว

    It's a very good video thanks

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @adammiah235
    @adammiah235 5 ปีที่แล้ว

    It is a very good video.......thanks ....

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @superiorslush5147
    @superiorslush5147 หลายเดือนก่อน

    every good 3d biochemistry animation has a british accent

  • @wassmmd8521
    @wassmmd8521 3 ปีที่แล้ว

    Very nice

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @abhiriseagain9303
    @abhiriseagain9303 4 ปีที่แล้ว

    awesome vid thank youu

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว +1

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @abhiriseagain9303
      @abhiriseagain9303 3 ปีที่แล้ว

      @@samarrowsmith1396 Hey thank you so much for your video. I searched for DNA repair and your video came up in search results..I watched many , this was the best one. For me this video was very beneficial in understanding the topic easily. And the animation was amazing, gave a clear picture. These are the topics which confuses some, so people tend to search for this kind of videos maybe thats why and you did a great job with the video.

  • @muskanpathan7623
    @muskanpathan7623 6 ปีที่แล้ว

    Wow!!!!

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @nareshsheoran2298
    @nareshsheoran2298 6 ปีที่แล้ว

    Very nice sir

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @7mikepd
    @7mikepd 7 ปีที่แล้ว +12

    i think it's dna polymerase I that fills in the nucleotides before ligase fills in the nick.

    • @camelliaxie9381
      @camelliaxie9381 7 ปีที่แล้ว +8

      Pol I is for proof reading and Nick translation (replacing RNA primers between Okazaki fragments). Pol III is for elongation, so the video is correct.

    • @zsusanner
      @zsusanner 6 ปีที่แล้ว +2

      The video is correct. It is DNA polymerase III that fills the gap

  • @katarinala
    @katarinala 7 ปีที่แล้ว +1

    THANK YOU, it was so confusing in my book!

  • @priyasultania8943
    @priyasultania8943 5 หลายเดือนก่อน

    Dam good

  • @anilk1241
    @anilk1241 7 ปีที่แล้ว +2

    great video !!
    - a medical student

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @AlessandroDonaggio
    @AlessandroDonaggio 3 ปีที่แล้ว

    hope you got a first for this!

  • @mcpba3857
    @mcpba3857 5 ปีที่แล้ว +3

    1:15

  • @agri_lover_boy1292
    @agri_lover_boy1292 3 ปีที่แล้ว

    Please apki volume high kordo

  • @stephenhawking9155
    @stephenhawking9155 2 ปีที่แล้ว

    How can i pay you. You just saved me ❣️❣️❣️

  • @eugenealice6839
    @eugenealice6839 5 ปีที่แล้ว +2

    nice

    • @NT20817
      @NT20817 5 ปีที่แล้ว +1

      rlly nice

    • @aliceeugene6871
      @aliceeugene6871 5 ปีที่แล้ว +1

      Hey what’s up Nate ?

    • @NT20817
      @NT20817 5 ปีที่แล้ว +1

      Alice Eugène chillin like a villain, n you?

    • @aliceeugene6871
      @aliceeugene6871 5 ปีที่แล้ว

      Cool, not me, I’m an hard worker today !

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว +1

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @JamSlapper
    @JamSlapper 5 ปีที่แล้ว +1

    MutS and MutL are heterodimers not homodimers, good vid though

  • @sanauzma6192
    @sanauzma6192 3 ปีที่แล้ว

    pleas sir be lauder i cant heat uhh

  • @jinglingu3465
    @jinglingu3465 7 ปีที่แล้ว

    旺德福!!!

  • @user-hf9wy5jp6x
    @user-hf9wy5jp6x 3 ปีที่แล้ว

    перевод на русский

  • @Futurescientist_
    @Futurescientist_ ปีที่แล้ว

    This is wrong first step hemimethylated GATC pe

  • @tarannumkhatoon5070
    @tarannumkhatoon5070 6 ปีที่แล้ว

    👌👌👌

  • @crazyfilms6562
    @crazyfilms6562 6 ปีที่แล้ว

    Very nice

    • @samarrowsmith1396
      @samarrowsmith1396  3 ปีที่แล้ว

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @crazyfilms6562
      @crazyfilms6562 3 ปีที่แล้ว

      Sir it's been 2 years now and I was in 12th standard at that time, after watching your video It made me easier to understand the concept and visualization makes it more memorable, now sir I am doing mbbs and hopefully became a doctor.🙏