DNA Damage Response

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  • เผยแพร่เมื่อ 16 ก.ค. 2017
  • Illustrated is the power of combined interference with different DNA damage response processes to combat cancer: Homologous recombination, which is selectively deficient in the tumour due to the BRCA defect, and base excision repair of single strand breaks, which is blocked by the administration of PARP inhibitors.
    Client:
    Dr. Rini de Crom
    Dr. Marja Miedema
    www.erasmusmc.nl, 2014
    www.ddresponse.eu/
    Funded by the 7th Framework Programme of the European Commission in the theme Health.
    More videos from DEMCON Nymus 3D on:
    www.demcon-nymus3d.nl
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ความคิดเห็น • 823

  • @simpleidea2825
    @simpleidea2825 ปีที่แล้ว +652

    Thank to all those doctors and scientists that enable us to understand our complex body and also saved millions of peoples.

    • @mr_derpaderpy4107
      @mr_derpaderpy4107 ปีที่แล้ว

      doctors dont discover diseases or find their cures, scientists do

    • @artemack9358
      @artemack9358 ปีที่แล้ว +15

      @@theeditor1072what for?

    • @ritu-p6013
      @ritu-p6013 ปีที่แล้ว +15

      @@artemack9358 to give us brain and all knowledge

    • @Rikka_V1
      @Rikka_V1 ปีที่แล้ว +1

      I hate those scientists because now as students we need to study all of it. How tf did they discover these anyway. They should had just focussed on politics to save people instead.

    • @Goutham1826
      @Goutham1826 ปีที่แล้ว +13

      @@Rikka_V1 you should be 9

  • @danielpopadic4314
    @danielpopadic4314 3 ปีที่แล้ว +1465

    I love how you can explain such difficult to comprehend topic to people with 0 health knowledge by using animations , if I had to learn it from book or just text I would waste hours trying to picture 🖼️ the movements in cells

    • @outofthebox9699
      @outofthebox9699 ปีที่แล้ว +9

      Yeah and it just randomly evolved, just like Smart Phones.

    • @sahasra_loveyourself_
      @sahasra_loveyourself_ ปีที่แล้ว +3

      Yes fr

    • @derickd6150
      @derickd6150 ปีที่แล้ว +17

      @@outofthebox9699 Ahhh right and we also just randomly found dinosaur bones that the same science that made this video also tells us is millions of years old, not to mention various shaped skulls dating back hundreds of thousands of years. You can't pick and choose which parts of science you believe

    • @outofthebox9699
      @outofthebox9699 ปีที่แล้ว +1

      @@derickd6150Get lost sick punk, ur brain is too dumb to understand what I said.

    • @el_chico1313
      @el_chico1313 ปีที่แล้ว

      @@outofthebox9699 ur stupidity just randomly evolved like a byproduct of nature u clown

  • @alienspecies6872
    @alienspecies6872 ปีที่แล้ว +1280

    As a biology student I can say this is amazing.

    • @outofthebox9699
      @outofthebox9699 ปีที่แล้ว +15

      Yeah and it just randomly evolved, just like Smart Phones.

    • @vunknownvictory
      @vunknownvictory ปีที่แล้ว +32

      I hate that I can understand in TH-cam, but not in class😅

    • @bittertruth4847
      @bittertruth4847 ปีที่แล้ว

      @@outofthebox9699 sound as logical as god allowing marriage between a 6 year old and a 54 year old 🤡

    • @_dyson
      @_dyson ปีที่แล้ว +9

      As a maths students this amazed me also

    • @UV_Lightning
      @UV_Lightning ปีที่แล้ว +20

      @@outofthebox9699 Yes, through billions of years of trial and error.

  • @anuskaroy7640
    @anuskaroy7640 ปีที่แล้ว +380

    God bless all doctors, nurses and good scientists

    • @blueshoregaming1591
      @blueshoregaming1591 ปีที่แล้ว +42

      I love how you said "good scientists".

    • @as_if
      @as_if ปีที่แล้ว +26

      Good doctors, good nurses

    • @Lousy_Bastard
      @Lousy_Bastard ปีที่แล้ว +12

      Plenty of bad medical professionals about this planet at this present time, who will never be forgiven for what they have done.

    • @ariankhan8371
      @ariankhan8371 ปีที่แล้ว +17

      @@as_if before good doctors and good nurses
      You should say good scientist than say doctors and nurses
      Scientist test science before doctors than doctors apply that tested science on patients
      Big salute to scientists who pulled humanity from pandemic

    • @thakursakshi_997
      @thakursakshi_997 ปีที่แล้ว +8

      Good teachers are also in the line of blessing🙌

  • @kookimers6809
    @kookimers6809 ปีที่แล้ว +158

    This is all we need...well done!! Even non medical or bio student/person can understand these easily

    • @rgw5991
      @rgw5991 7 หลายเดือนก่อน

      men get cancer too. sheesh.

  • @JoshCaiLovzu
    @JoshCaiLovzu 2 ปีที่แล้ว +269

    0:50 homologous recombination repair... the solution is just jaw-dropping

    • @indiabiologyexplains5013
      @indiabiologyexplains5013 ปีที่แล้ว +24

      It's also essential in CRISPR cas9 editing

    • @unitedstatesirie7431
      @unitedstatesirie7431 ปีที่แล้ว +2

      Chlorine Dioxide pulls away the ELECTRONS from the Cancer cells. No harmful effects to body parts. This is the hidden cure for all types of Cancers.

    • @mihaelwolrk2143
      @mihaelwolrk2143 ปีที่แล้ว +1

      @@indiabiologyexplains5013 One question, with CRISP you can change your hair from curly to straight.

    • @3alaiyer
      @3alaiyer ปีที่แล้ว +24

      Indeed, God is the best of creators.. We’re not even aware all these things are going on in our bodies

    • @unitedstatesirie7431
      @unitedstatesirie7431 ปีที่แล้ว

      @@3alaiyer if you want more cure details send me you e-mail address.

  • @colbyandbrennen3543
    @colbyandbrennen3543 ปีที่แล้ว +62

    The human body never fails to impress me learning through animations like this

    • @wakzies
      @wakzies ปีที่แล้ว

      SHOW YOUR HUMAN BODY 🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥V

  • @BillKinsman
    @BillKinsman ปีที่แล้ว +74

    My mother, grandmother and sister all have this gene mutation. I may in fact have it. It is incredible to know what happened now. It is hard to believe how much progress has been made in the past 50 years.

    • @alexshapiro9841
      @alexshapiro9841 ปีที่แล้ว

      The only thing hard here is your stupid brain

    • @UnpluggedAi
      @UnpluggedAi ปีที่แล้ว

      th-cam.com/video/SwNX2gSbgso/w-d-xo.html

  • @dis9078f
    @dis9078f หลายเดือนก่อน +2

    As an engineer student I find it absolutely mesmerizing

  • @Donotdisturb12441
    @Donotdisturb12441 ปีที่แล้ว +94

    I just love how to make it easy and explain each and everything (it's causes and treatment)

  • @ZenithalPoint
    @ZenithalPoint ปีที่แล้ว +7

    Everytime I see this sort of video, I feel like continuity of my existence as a lifeform itself is some kind of miracle and I could die any second in afterward

  • @happinessallover
    @happinessallover ปีที่แล้ว +111

    Not a biology student but understood what these people explained.

    • @alexshapiro9841
      @alexshapiro9841 ปีที่แล้ว +5

      no you didn't, FOOL

    • @happinessallover
      @happinessallover ปีที่แล้ว +7

      @@alexshapiro9841 LMAO DED.

    • @monolinny1817
      @monolinny1817 ปีที่แล้ว

      @@alexshapiro9841 th-cam.com/video/RYDy_nlgi5Q/w-d-xo.html

    • @lucienkennedy1997
      @lucienkennedy1997 ปีที่แล้ว +2

      @@alexshapiro9841 Stop gatekeeping

    • @bibaRU
      @bibaRU 7 หลายเดือนก่อน

      ​@@alexshapiro9841what is hard of getting it? If DNA isn't getting repaired cell becoming a cancel cell.

  • @nimishnandedkar9278
    @nimishnandedkar9278 ปีที่แล้ว +86

    Our body is so fascinating . Respect for my body is increased after this video ♥️🔥

    • @tphone6717
      @tphone6717 ปีที่แล้ว +5

      Not for the Maker?

    • @_emminowithoutl4995
      @_emminowithoutl4995 ปีที่แล้ว +11

      @@tphone6717 don't exist...(wait are u talking about parents?)

    • @tphone6717
      @tphone6717 ปีที่แล้ว +6

      @@_emminowithoutl4995 you have a surprise waiting

    • @outofthebox9699
      @outofthebox9699 ปีที่แล้ว +2

      Yeah and it just randomly evolved, just like Smart Phones.

    • @salmanwatto6214
      @salmanwatto6214 ปีที่แล้ว

      @@_emminowithoutl4995 what about the ultimate maker ( also of our parents )

  • @MODEST500
    @MODEST500 3 ปีที่แล้ว +5

    you aall are so good at ur JOBS damn !!! May God bless you and reward you for your work . stay safe .

  • @noname8354
    @noname8354 7 หลายเดือนก่อน +2

    Bro tysm for making this video. I'm going to be writing a literature review on PARPi and BRCA1 cancers so this video helped explain everything in a very simple way

  • @xinking2644
    @xinking2644 2 หลายเดือนก่อน +2

    I can't explain how useful these video are for me to understand this complex theory. thanks, million times!

  • @dr.devendrasharma6367
    @dr.devendrasharma6367 ปีที่แล้ว +1

    Simply Beautiful in every aspect, from science to animation.

  • @noble2694
    @noble2694 ปีที่แล้ว +4

    Man the animation is so sick and beautiful. Thank you very much.

  • @mathewjoseph2237
    @mathewjoseph2237 ปีที่แล้ว +12

    This would have made high school biology class so much easier to understand.

    • @ttsuter87
      @ttsuter87 2 หลายเดือนก่อน +1

      Hopefully this type of learning helps further our understanding of these conplex topics. Visual learning is crucial for so many people.

  • @emperordrone1159
    @emperordrone1159 ปีที่แล้ว +5

    thankyou for being so much better than several other explaining this

    • @Nymus3D
      @Nymus3D  ปีที่แล้ว +3

      You are so welcome! We do our best! :)

  • @computerheadman1601
    @computerheadman1601 10 หลายเดือนก่อน +5

    The animation and explanation made it easy to understand, great vid 👍

  • @masoomshabir7221
    @masoomshabir7221 ปีที่แล้ว +1

    Love this video
    I'm happy knowing treatment for the deadly cancer.
    This is science of next level

  • @LoneFifteen
    @LoneFifteen ปีที่แล้ว +63

    All of this technological advancement, and my mom still died after being given the same treatment that they've been giving patients for fifty years. We need to push treatments like this to more people who need them and make them more wildly available.

    • @juliandiaz1457
      @juliandiaz1457 9 หลายเดือนก่อน +1

      A todo el mundo

    • @toota1052
      @toota1052 8 หลายเดือนก่อน

      😢

  • @WriterWriter4
    @WriterWriter4 ปีที่แล้ว +3

    I bear witness that there is no god but God, alone without partner.. Glory be to God and praise be to Him

  • @up5619
    @up5619 ปีที่แล้ว

    If this is an ad, it would be the type I would actually watch.

  • @sahilraj2355
    @sahilraj2355 ปีที่แล้ว +11

    Bro why do you have only 11k subs you deserve 11 million.🥺

  • @misskakouei6638
    @misskakouei6638 ปีที่แล้ว +1

    that was an amazing show, many thanks for your attempt to prepare it🙏💖

  • @lucienkennedy1997
    @lucienkennedy1997 ปีที่แล้ว +1

    Thank you so much for your work! Love it!

  • @amiramiro8843
    @amiramiro8843 ปีที่แล้ว +5

    Thank you for that amazing and easy explanation of this ❤️❤️❤️❤️

  • @marcelnowakowski945
    @marcelnowakowski945 3 หลายเดือนก่อน +1

    Absolutely fascinating!
    Thank you for this awesome animation!

  • @Inspiration.U
    @Inspiration.U ปีที่แล้ว +5

    Very informative..learning in innovative way..really explained well in best ever experience..commendable and appreciable!!

  • @OmBirajdar
    @OmBirajdar 8 หลายเดือนก่อน +3

    Understanding biology by animation is genius

  • @brukujinbrokujin7802
    @brukujinbrokujin7802 ปีที่แล้ว +3

    People dont realize that DNA is language of the Gods.

  • @colinmerritt7645
    @colinmerritt7645 7 หลายเดือนก่อน +1

    Our bodies are amazing!

  • @dairms
    @dairms ปีที่แล้ว

    Wow, this is absolutely fascinating.

  • @Algebrainiac
    @Algebrainiac 20 วันที่ผ่านมา

    This is amazing! Props to the animators. Amazing explanation

  • @thakursakshi_997
    @thakursakshi_997 ปีที่แล้ว +3

    Thanks for this beautiful explanation 💓

  • @user-eg5cy8gt9x
    @user-eg5cy8gt9x 3 หลายเดือนก่อน

    This is really impressive, and as a biology student I now understand the diseases that might affect cells of DNA and the prevention process.

  • @Hannodb1961
    @Hannodb1961 ปีที่แล้ว +2

    How amazingly we were designed.

  • @TrondHelm
    @TrondHelm 3 ปีที่แล้ว +43

    Brilliant video, awe inspiring.

    • @Nymus3D
      @Nymus3D  3 ปีที่แล้ว +13

      Thanks so much!

    • @mmd123king6
      @mmd123king6 2 ปีที่แล้ว +3

      @@Nymus3D do they have a copy of the dna from the PCR or they just copy whatever was damaged from the dna?

    • @mmd123king6
      @mmd123king6 2 ปีที่แล้ว +2

      @@Nymus3D thank you so much for making this veidio ❤❤❤

    • @fullentertainmentbyat4067
      @fullentertainmentbyat4067 ปีที่แล้ว

      th-cam.com/users/shortscD7vOkhYZpA?feature=share

  • @BamiAndCheese
    @BamiAndCheese ปีที่แล้ว +1

    I was actually busy studying on this EXACT subject for biology, so I appreciate this video *

  • @Aviink
    @Aviink ปีที่แล้ว +2

    These calm me down for some reason and so do "How It's Made" vids.

  • @ranjanasah5619
    @ranjanasah5619 ปีที่แล้ว +5

    The way of explaining this topic, is just amazing 🌼

  • @autismunion
    @autismunion 5 ปีที่แล้ว +26

    Perfect!! God bless you

    • @Nymus3D
      @Nymus3D  5 ปีที่แล้ว +5

      Thank you Anwar!

    • @autismunion
      @autismunion 2 ปีที่แล้ว +5

      @Imperial Terra it is just figure of speech, I dont believe in god either

    • @_emminowithoutl4995
      @_emminowithoutl4995 ปีที่แล้ว

      @@autismunion lol

    • @_emminowithoutl4995
      @_emminowithoutl4995 ปีที่แล้ว

      @@autismunion me neither brother

  • @jyotigupta7821
    @jyotigupta7821 ปีที่แล้ว

    I loved the way of her explanation by 3D demantions

  • @rubiks.cube0008
    @rubiks.cube0008 ปีที่แล้ว +7

    Such designs so complicated and seem to be moving on its own with such delicate and amazing feats yet humans concludes that this is the result of random elements and dust clustering on its own with the help of time, lightning, heat and light is enough to produce such intricate work of arts.

  • @terryliu9015
    @terryliu9015 ปีที่แล้ว +3

    does anyone else find these things so fascinating? to me it feels like a fairy tale where everything just works out perfectly

  • @jonayedrejaul7681
    @jonayedrejaul7681 ปีที่แล้ว +1

    That explanation is really great🥰

  • @jasonvoorhees8899
    @jasonvoorhees8899 ปีที่แล้ว +1

    Please put such videos in a playlist.

  • @PortableKonfidence
    @PortableKonfidence 9 หลายเดือนก่อน +1

    Extremely clear and understandable. Thank you

  • @ag-bk5wf
    @ag-bk5wf หลายเดือนก่อน

    Amazing how the body works.

  • @XavierAway
    @XavierAway ปีที่แล้ว +1

    Thank you for not dumbing it down

  • @allenjiang7017
    @allenjiang7017 2 หลายเดือนก่อน +1

    As a science history and biology student (even though I have more lessons) this is amazing.

  • @edenleave2054
    @edenleave2054 ปีที่แล้ว +4

    Wow this explained it better than my medical school

  • @-RightWay-
    @-RightWay- ปีที่แล้ว +4

    Thank you
    Most helpful video 👌🏼👌🏼👌🏼

  • @cibeleanjos3051
    @cibeleanjos3051 3 หลายเดือนก่อน

    Thank you for video I am student of nurse and these video animations help me of lot🙌

  • @brendataylor1467
    @brendataylor1467 ปีที่แล้ว

    Very well explained easy to understand Thank you .

  • @areebaaziz6796
    @areebaaziz6796 ปีที่แล้ว

    Now I come to know that how breast cancer arises and repaired you have explained very well

  • @letstalkourself
    @letstalkourself ปีที่แล้ว +1

    I love it what ur going to explain how magic is this i didn't understand this magic when I am in class

  • @XY-yg1ci
    @XY-yg1ci 2 หลายเดือนก่อน +1

    really helpful!!! better than textbooks

  • @ExploringworldwithSWAT
    @ExploringworldwithSWAT ปีที่แล้ว

    Underrated channel 😔

  • @INeedAPrenupSorry
    @INeedAPrenupSorry 5 หลายเดือนก่อน

    Thats amazing how our bodies work like this

  • @ashudhaliwal9524
    @ashudhaliwal9524 ปีที่แล้ว +2

    It's super amazing to understand the concept of biology ♥️❤️🥺❤️

  • @p_p21
    @p_p21 ปีที่แล้ว

    Grt video during study I always use to assume that how these DNA break and repair through this animation now I understood that. 😁😘

  • @nirbhay_raghav
    @nirbhay_raghav ปีที่แล้ว +27

    Although it is not that simple as stated in the video, I loved the animation and narration.

    • @noname8354
      @noname8354 7 หลายเดือนก่อน +1

      Ofc it's not that simple we're talking about biology here. That said, this is a very good summary of what happens and proves a great foundation for people to learn more if they want to

  • @raskolnikov1461
    @raskolnikov1461 4 หลายเดือนก่อน

    Sounds AMAZING

  • @zoem491
    @zoem491 2 หลายเดือนก่อน

    The graphics are amazing 😮

  • @deepsachin3951
    @deepsachin3951 ปีที่แล้ว +1

    Beautiful animation...

  • @rkm17823
    @rkm17823 ปีที่แล้ว

    thank you for this information

  • @chynnadoll3277
    @chynnadoll3277 ปีที่แล้ว +1

    How great Thou art, indeed Heavenly Father❤❤❤❤❤❤

  • @kjj26k
    @kjj26k 2 หลายเดือนก่อน

    The only thing more insane than the complex specificity of cellular biology is that we are able to, from our human scale, be that specific down there in the micro world.

  • @geethar6090
    @geethar6090 ปีที่แล้ว

    This is amazing

  • @stanb1543
    @stanb1543 ปีที่แล้ว +1

    stellar graphics!

  • @torahama362
    @torahama362 ปีที่แล้ว

    Truly magical

  • @Kh471D
    @Kh471D 6 ปีที่แล้ว +7

    amazing ! , thanks :-)

  • @morganh0421
    @morganh0421 ปีที่แล้ว

    These organisms are living quite an interesting life!

  • @asanablue
    @asanablue ปีที่แล้ว

    Excellent video.

  • @vrindaaaggarwal4021
    @vrindaaaggarwal4021 ปีที่แล้ว

    Fascinating!

  • @ok-ns7ri
    @ok-ns7ri ปีที่แล้ว +3

    POV: you're the first to fall asleep at a sleepover (rookie mistake)

  • @realmenarzo7720
    @realmenarzo7720 ปีที่แล้ว

    Thank you 🙏

  • @lt4128
    @lt4128 ปีที่แล้ว +1

    Excellent voice🇮🇳 👍
    and music 👍

  • @ramrad5905
    @ramrad5905 ปีที่แล้ว

    Fantastic, that's awesome.

  • @cks2020693
    @cks2020693 ปีที่แล้ว +1

    easily 10 hours' worth of grad-school medical knowledge explained in under 4 mins

  • @ttsuter87
    @ttsuter87 2 หลายเดือนก่อน

    This is all amazing but how these proteins know that’s there job to repair DNA is amazing to me. How the is a subtle chemical process that causes this specific action is amazing. DNA is a wonder.

    • @strong_241
      @strong_241 27 วันที่ผ่านมา

      Glory be to God, the best of creators ✨

  • @foundingtitan7
    @foundingtitan7 ปีที่แล้ว +1

    The human body fascinates me ❤

  • @opufy
    @opufy ปีที่แล้ว +1

    If I got proper training, I could work what a team to helps in solving things so intricate as this.

  • @amorakareem8072
    @amorakareem8072 ปีที่แล้ว

    Thank you very much

  • @user-lv1ir1kq4p
    @user-lv1ir1kq4p 6 หลายเดือนก่อน

    Really just awesome❤

  • @mariadoamparoabuchaim349
    @mariadoamparoabuchaim349 ปีที่แล้ว

    Fantástico as defesas no DNA-

  • @rubiks6
    @rubiks6 ปีที่แล้ว +2

    You cannot tell me this is not designed by an incredible mind. The work of God is clearly seen here in the various DNA repair systems.

  • @deeprollingriver52
    @deeprollingriver52 10 หลายเดือนก่อน

    We should all be amazed and revere our bodies.

  • @bomberjoe3493
    @bomberjoe3493 8 หลายเดือนก่อน +1

    Another lesson we can benefit

  • @upendarkumar-on9ks
    @upendarkumar-on9ks 16 วันที่ผ่านมา +1

    Background music.. exited..❤️

  • @Heroesflorian
    @Heroesflorian ปีที่แล้ว +2

    I can't help but think that explanation is missing a crucial part. It says some patients lacking double strand break repair functionality due to their inheritance is what causes the cancer, but then proceeds to state that the ability to repair double strand breaks is what prevents all the non-cancer cells from dying as well.
    Without additional information, those two statements feel a bit contradictory to each other: An issue caused by the inherited lack of an ability is fixed based on trusting in the very same ability the lack of which caused the issue, and killing anything with a lack of that ability.

  • @WitmanClan
    @WitmanClan ปีที่แล้ว

    Thank you 🙏🧬🙏

  • @3dgar7eandro
    @3dgar7eandro 10 วันที่ผ่านมา +1

    Wow 😲😳 or bodies and biology are actually amazing!!!

  • @joebarrett4353
    @joebarrett4353 ปีที่แล้ว

    Extraordinary

  • @alishaanimations3058
    @alishaanimations3058 หลายเดือนก่อน

    Rewatching definitely!
    Amazing visuals, I saw how the heart interconnects to everything, furthered my A level knowledge and changed my interest for genetics and mutation to a more positive one (not just related to plants and stuff)
    Furthered my interest in the immune system
    Also I love the patient examples it made me put it into a realistic perspective, connecting humans to the biology of the internal bodily processes taught eg. Showing how inhibitor is pumped into bloodstream when like the thing is attached to them
    Maybe I should evaluate further methods with blooms taxonomy questions in higher level, see if stuff woyld be removed
    And also research more about genetics and mutation of dna within body and how it connects to disease, cancers, tumours
    Research cancer in more depth, breast cancer, how to treat patient with breast cancer, watch more videos :)

  • @alexandermellizoordonez7017
    @alexandermellizoordonez7017 ปีที่แล้ว

    Simplemente maravilloso
    DIOS eres tan grande y te alabo

  • @mathisnotforthefaintofheart
    @mathisnotforthefaintofheart ปีที่แล้ว +1

    I find cancer one of the most scariest diseases. And I have adjusted my diet accordingly. Lots of fruits and veggies, very little red meat (and meat in general), fish and eggs are fine. Once a month soda, rest green tea and water.