Love seeing a channel using actual labs to see efficacy of a supplement. Ive done my own personal testing with peptides and have been happily surprised with the results but havent seen it for NMN. Would be interested to see of you do any other supplements
@@robbertag808 Ipamorelin & cjc1295 increased my igf-1 from 62 to 162 over 4 months. Happy there. Biotech peptides. I also did a month of bpc-157. No labs done for bpc
Great video! been super interested in NAD+ and precursors like NMN for a bit and appreciate you sharing your experience. one small correction is that μM is “micromolar” in this context, meaning you had that many moles of NAD+ per liter of blood (im sure you’ll get other comments on this tho lol) keep up the fantastic videos, cant wait for the next one!
You mean a lower-case “m” is meter (not micrometer). The "µ" is for micro. So, "µm" means micrometer. You Americans will get it,... eventually! You just need the education others get in the kindergarten. We think you are funny when you try to use u its, and hilarious when you use a number without guving the unit.
Thank you so much for making this amazing content man. Super informative and interesting! I've been fascinated by NMN and resveratrol since David Sinclair mentioned them. Have you tried resveratrol by any chance? Keep up the great work!
Really appreciate the "Stay informed" section of the description linking research and publications! Also, NMN does work to increase NAD+ levels, exogenous supplementation at your age is probably not what you should approach due to concerns about transient effects of NAD+ precursor supplementation (at least NMN/NR) and un-optimal facets/alternatives with your lifestyle/practicality (Calorie restriction, Ketogenic diet, Niacin, etc.). Some further comments about the second point: E.g. If you haven't eaten and your glucose levels are measured to be low, the immediate solution would be to have a meal rather than have a dextrose IV (goes to illustrate down the line issues beyond a point in time measurement as well, etc.).
I took it and my kidneys hurt like hell and I felt like I could run less and low-key depressed. Overall, I was most concerned about why my kidneys hurt like hell though the reason the bandit is because they haven’t done enough studies to see its effectiveness or the cons of taking the drug when I turned 31. Be sure to do your research before you take drugs guys just because it works on a mouse doesn’t mean it’s gonna work on you.
So Big Pharma knows NMN works and want to be the only ones to profit from it. Something that is widely available and relatively cheap will be reclassified as a drug and called something like Maximumipab and sold for thousands of dollars. Capitalism sucks for those at the bottom.
Love your content! It would be interesting to see a video where you take NR for 30 days to see if there's a difference in NAD+ levels between the two supplements. From your research, is there anything to suggest that one is better than the other?
I’ve been taking NMN for about 6 months or so now. My self report would be very similar to what you feel. It’s not a burst of energy but just a slow and steady stream of energy. Also, NMN has been one of the few supplements I’ve taken that I noticed an actual difference in my daily life. Low activity or no activity days I don’t really take it and on high activity days I’ll take between 400-1200mg. I really notice it especially when I take 1200mg. High activity - lifting weights and playing sports in the same day. 37 yo male here.
Yeah I've seen a lot of people report a "huge" increase in energy levels. I really didn't feel that way, but I do feel good on it. Cool to hear about your experience.
@@Project.Andrew I suspect the huge increase of energy is probably from people with really low NAD levels. If you have NAD of 5 and increase it to 10 that's a huge, if you have 30 and increase it to 35 you don't notice it as much.
Hey! I like your content.. just a suggestion, you can improve your story telling by updating us over say the next 5,10,15,25 and 30th days.. indicating progress or no progress. Thanks!
@@Project.Andrew That's great! I heard a lot from NAC from Hubermans Podcast (Cold & Flu). So I am looking forward for your test. I have already ordered NAC 🙂
Thing is with NMN is that it helps older people much more than younger ones..most younger people have enough NAD so you won't notice any improvements....
Yeah, I could see that. I’d imagine someone that was severely deficient would notice a big difference. Fun to experiment with this stuff as a younger person. The thing is, most people in the longevity space are quite a bit older than me. The general advice for people my age is to get good sleep, diet, and exercise. Which is good, just doesn’t make the most interesting content imo.
@@Project.Andrew resveratrol is one to figure out...not a slam dunk like they thought...what is the right way to take Fisetin..everyday or big doses periodically?....Spermidine?...Can we even absorb it?...Endless questions in longevity...
@@fishnski9211 trying spermidine now. Hard to get accurate end point measurement though. Really interested in resveretrol. Will see what I can do with a video around that
@@Project.Andrew spermidine as of the latest study doesn't get absorbed...Confusing since there is so much good vibe with it....I'm trying to figure out the best way to take Fisetin...... ...NAC/Glycine seems legit..... Apigenin...Ect..lots out there...I'm thinking low doses of everything until further notice...
It is really expensive. In my opinion, the best thing to do is really dial in diet, sleep, and exercise. Once those are dialed in, then expanding to supplementation and more expensive interventions makes sense. 80%-90% of be benefits come from the boring things most people don't want to do.
Resveratrol has been the only supplement that I’ve noticed something different when taking. I get VIVID dreams. I’ve not seen anyone mention vivid dreams as a side effect or benefit, and it’s not listed. I continue to take it for this reason only 😅 it must affect the brain somehow.
When your puppy playfully snapped at your face you needed to seriously discipline it then and there. That behavior is unacceptable and could easily result in a child or someone being hurt badly later on as your pup develops already knowing that it can do this with no negative outcome to itself... I know exactly what I am talking about so please take this on. On another note...subbed to your channel for the excellent informative no BS content. Thank you.
The misdirect here is NMN developed by Dr David Sinclair team, and requested it be taken of the market and they now want to it be classified as a prescription. $$$$ All for the great good of humankind. Yeah
There seems to be a lot of conflicting information as to its effectiveness. I have taken it myself on and off for some time with mixed results. Some research even suggests niacin alone can achieve the same benefits for a lot less. For now, I am going to wait on more studies.
I’m not sure it’s as conflicting as it is dosage dependent. Attia recently reacted to a study on it where he talked about it not being effective, but the does was 1/4th what I took. Sinclair and Huberman are still pretty bullish on it. At the end of the day my NAD+ levels went up, so it at least worked for that. But I feel what you’re saying. It’ll be interesting to see what more studies show.
@@Project.Andrew Some studies seem to indicate NAD+ alone can be an effective substitute. Would you agree? If not, would you have a discount code for AlphaCell? Thx
It's definitely on my list, I just have a lot I'm trying to get through in terms of reading. Would love it if you shot an email my way (andrewboyd.ytc@gmail.com) with any ideas for future videos.
With the cost of the supplement, I don’t see much of a difference between the free market and the pharmaceutical companies 🤷♂️ free market is about things being cost-effective
Not sure it matters but in the video you can clearly see that the drop of NAD fixing buffer didn't even hit the actual blood sample on the card. Unless you had applied more drops your baseline results might not be accurate.
Same experience here. Must have been mildly deficient too. Too much missed sleep and poor eating in my 20s. Everything is just, clearer. It's like yeah there's problems with my body but things seem to be functioning more efficiently.
Nmn taps from your methyl groups, so you make some tmg, but depending on how much Nmn your taking, it might be good to supplement with tmg as a,precaution to prevent methyl groups from getting low. It’s cheap and doesn’t hurt. Maybe take tmg at night if you take Nmn in the morning so the Nmn has a good bank to work with.
if your viewers have to skip three quarters of your content that's probably a good indication there is too much filler in your content... @@Project.Andrew
its too bad , your channel had the most potential I have ever seen and then this. Oh well, you will likely make more money off supplements anyways. You are a little young and very early in your channel for a video like this.
I knew I’d get a few comments like this. Because of that I was a bit reluctant to make the video. But I went ahead with it because I was able to show that it worked for me, and the company has high standards (3rd party tested, TGA regulated). I wish you could see the number of sponsors I’ve turned down that are actually selling snake oil.
In this world there are those who create and those who can not, so their only way of trying to obtain any recognition is to try and destroy. As humans, we often are affected more by the negative giving it our attention. This is a survival mechanism, but it is important at a point to just tell those MFs to F... off and get a life. Carry on doing what you are doing mate. You are a creator, not a loser.
It’s micro-molar, not micro-meter. My bad 😅
I was scratching my head as well with the meter nomenclature but, was hey we have a number, a range chart so it can be called whatever hahaha
you have to take nmn with fat or oil.
Thank goodness you corrected... so weird for us biochem people when units are wrong.
Love seeing a channel using actual labs to see efficacy of a supplement. Ive done my own personal testing with peptides and have been happily surprised with the results but havent seen it for NMN. Would be interested to see of you do any other supplements
What kind of peptides and brand?
@@robbertag808 Ipamorelin & cjc1295 increased my igf-1 from 62 to 162 over 4 months. Happy there. Biotech peptides. I also did a month of bpc-157. No labs done for bpc
Great video! been super interested in NAD+ and precursors like NMN for a bit and appreciate you sharing your experience. one small correction is that μM is “micromolar” in this context, meaning you had that many moles of NAD+ per liter of blood (im sure you’ll get other comments on this tho lol) keep up the fantastic videos, cant wait for the next one!
Hahahaha yeah I got another comment on that already. Turns out a lower-case “m” is micrometer…. Thanks for the comment! Always learning on TH-cam.
You mean a lower-case “m” is meter (not micrometer). The "µ" is for micro.
So, "µm" means micrometer.
You Americans will get it,... eventually!
You just need the education others get in the kindergarten.
We think you are funny when you try to use u its, and hilarious when you use a number without guving the unit.
@@larsnystrom6698 hahaha thanks. I'm learning. Slowly but surely.
I am from an Arab country and I do not speak English Is this product guaranteed and safe?How do I get this product?
Thank you so much for making this amazing content man. Super informative and interesting! I've been fascinated by NMN and resveratrol since David Sinclair mentioned them.
Have you tried resveratrol by any chance?
Keep up the great work!
Really appreciate the "Stay informed" section of the description linking research and publications!
Also, NMN does work to increase NAD+ levels, exogenous supplementation at your age is probably not what you should approach due to concerns about transient effects of NAD+ precursor supplementation (at least NMN/NR) and un-optimal facets/alternatives with your lifestyle/practicality (Calorie restriction, Ketogenic diet, Niacin, etc.).
Some further comments about the second point: E.g. If you haven't eaten and your glucose levels are measured to be low, the immediate solution would be to have a meal rather than have a dextrose IV (goes to illustrate down the line issues beyond a point in time measurement as well, etc.).
Could you discuss more about these transient effects?
I took it and my kidneys hurt like hell and I felt like I could run less and low-key depressed. Overall, I was most concerned about why my kidneys hurt like hell though the reason the bandit is because they haven’t done enough studies to see its effectiveness or the cons of taking the drug when I turned 31. Be sure to do your research before you take drugs guys just because it works on a mouse doesn’t mean it’s gonna work on you.
Hey I Landed on your channel from your linkedin profile, and know what..the video was cool!
Hello Andrew, were waiting for some new content. Keep up the good work!
On it! New video dropping soon (hopefully the end of this week).
@@Project.Andrewguess he is dead 🤪🤷🏻♂️
@@alMighty8989 Longevity fail 😂
Good job man, keep up the great videos!
This is very interesting. Thanks for the demonstration!
No problem!
So Big Pharma knows NMN works and want to be the only ones to profit from it. Something that is widely available and relatively cheap will be reclassified as a drug and called something like Maximumipab and sold for thousands of dollars. Capitalism sucks for those at the bottom.
You got a dog?! Also you the results from this are baffling 🤯 appreciate you testing it out!
Nice video been looking for a good Aussie supplier of NMN never tried it. Ordered 4 months on your link. 😉👍
🫡🫡👌 I hope you enjoy. Seems like a good company to me.
Great content as always
Love your content! It would be interesting to see a video where you take NR for 30 days to see if there's a difference in NAD+ levels between the two supplements. From your research, is there anything to suggest that one is better than the other?
I am actually in the process of making that video happen! :)
Nmn better
I’ve been taking NMN for about 6 months or so now. My self report would be very similar to what you feel. It’s not a burst of energy but just a slow and steady stream of energy. Also, NMN has been one of the few supplements I’ve taken that I noticed an actual difference in my daily life. Low activity or no activity days I don’t really take it and on high activity days I’ll take between 400-1200mg. I really notice it especially when I take 1200mg. High activity - lifting weights and playing sports in the same day. 37 yo male here.
Yeah I've seen a lot of people report a "huge" increase in energy levels. I really didn't feel that way, but I do feel good on it. Cool to hear about your experience.
@@Project.Andrew I suspect the huge increase of energy is probably from people with really low NAD levels. If you have NAD of 5 and increase it to 10 that's a huge, if you have 30 and increase it to 35 you don't notice it as much.
Hey! I like your content.. just a suggestion, you can improve your story telling by updating us over say the next 5,10,15,25 and 30th days.. indicating progress or no progress.
Thanks!
Could you make a Video of NAC (N-acetylcystein) as well? Would be very interesting
I’ll definitely look into it :) these sorts of videos are helpful to me as I build out my personal supplement stack.
@@Project.Andrew That's great! I heard a lot from NAC from Hubermans Podcast (Cold & Flu). So I am looking forward for your test. I have already ordered NAC 🙂
Im going to start taking Taurine instead.
Sorry if I missed it in the video, but for context on your NAD levels, how old are you?
He is 23
Which link to purchase this?
Thing is with NMN is that it helps older people much more than younger ones..most younger people have enough NAD so you won't notice any improvements....
Yeah, I could see that. I’d imagine someone that was severely deficient would notice a big difference.
Fun to experiment with this stuff as a younger person. The thing is, most people in the longevity space are quite a bit older than me. The general advice for people my age is to get good sleep, diet, and exercise.
Which is good, just doesn’t make the most interesting content imo.
@@Project.Andrew resveratrol is one to figure out...not a slam dunk like they thought...what is the right way to take Fisetin..everyday or big doses periodically?....Spermidine?...Can we even absorb it?...Endless questions in longevity...
@@fishnski9211 trying spermidine now. Hard to get accurate end point measurement though. Really interested in resveretrol. Will see what I can do with a video around that
@@Project.Andrew spermidine as of the latest study doesn't get absorbed...Confusing since there is so much good vibe with it....I'm trying to figure out the best way to take Fisetin......
...NAC/Glycine seems legit.....
Apigenin...Ect..lots out there...I'm thinking low doses of everything until further notice...
Problem is, NMN is very expensive. For me, it's best to find a food based source of MNM..
It is really expensive. In my opinion, the best thing to do is really dial in diet, sleep, and exercise. Once those are dialed in, then expanding to supplementation and more expensive interventions makes sense. 80%-90% of be benefits come from the boring things most people don't want to do.
@@Project.Andrew Thaks so much for your thoughtful reply...
@@ripperduck no problem! Sorry it’s not more exciting.
Old you do this for Resveratrol also? Low dose tho, like 250 mg every other day taken with fats or oil.
I'd like to. I'll see what I can do. Will have to do some research on what biomarkers to measure.
@@Project.Andrewresveratrol reduces testosterone
Resveratrol has been the only supplement that I’ve noticed something different when taking. I get VIVID dreams.
I’ve not seen anyone mention vivid dreams as a side effect or benefit, and it’s not listed. I continue to take it for this reason only 😅 it must affect the brain somehow.
Nice Work
Thanks!! Was fun to try. Planning to keep taking NMN. May do a 6 month update video.
Awesome 👍
Conflict of interest 100
When your puppy playfully snapped at your face you needed to seriously discipline it then and there. That behavior is unacceptable and could easily result in a child or someone being hurt badly later on as your pup develops already knowing that it can do this with no negative outcome to itself... I know exactly what I am talking about so please take this on. On another note...subbed to your channel for the excellent informative no BS content. Thank you.
Thanks for the sub, and thanks for the info on the pup. Working with him quite a bit, and he’s improving quickly :)
Interesting video, but did you mean to say mico-Molar instead of micro-Meter?
Yep. Looking it up and you’re right. Microns or micro-meters wavelength… looks like um vs uM
@@Project.Andrew Now worries! It is a classic mistake (one I have likely made myself too many times).
@@Dangineering really appreciate you letting me know! That’s the upside of TH-cam, I learn a ton by making this stuff and reading the comments.
The misdirect here is NMN developed by Dr David Sinclair team, and requested it be taken of the market and they now want to it be classified as a prescription. $$$$ All for the great good of humankind. Yeah
😊🙏👏
It would have been cool to see how it affects the rest of your biomarkers
I’m getting pretty regular blood work done. I’ll post a 6 month update with a full blood panel.
There seems to be a lot of conflicting information as to its effectiveness. I have taken it myself on and off for some time with mixed results. Some research even suggests niacin alone can achieve the same benefits for a lot less. For now, I am going to wait on more studies.
I’m not sure it’s as conflicting as it is dosage dependent. Attia recently reacted to a study on it where he talked about it not being effective, but the does was 1/4th what I took. Sinclair and Huberman are still pretty bullish on it. At the end of the day my NAD+ levels went up, so it at least worked for that. But I feel what you’re saying. It’ll be interesting to see what more studies show.
@@Project.Andrew Some studies seem to indicate NAD+ alone can be an effective substitute. Would you agree? If not, would you have a discount code for AlphaCell? Thx
I feel great off NAC+
Did I miss him saying how often and at what dose?
Daily, 500mg. Hope this helps! Will retest in 6 months to see where my levels are at, then will adjust from there.
Riagev vs nmn?
I'm not sure
I hope you read How Not To Age. No doubt many videos ideas would come out of it.
It's definitely on my list, I just have a lot I'm trying to get through in terms of reading. Would love it if you shot an email my way (andrewboyd.ytc@gmail.com) with any ideas for future videos.
Any side effects?
Nothing that I noticed.
With the cost of the supplement, I don’t see much of a difference between the free market and the pharmaceutical companies 🤷♂️ free market is about things being cost-effective
Well, of course your nad levels went up. The real question is whether it does any good.
Anecdotally, I feel good. But that’s not worth much.
At the end of the day it’s like a lot of things in health/longevity. We don’t know enough yet.
How much u take????😅😅😅😅😅
Not sure it matters but in the video you can clearly see that the drop of NAD fixing buffer didn't even hit the actual blood sample on the card. Unless you had applied more drops your baseline results might not be accurate.
Look again. You can see the outline of multiple drops 👌
@@Project.Andrew dunno at 1:08 all i see is one drop not hitting the blood but if you think you got it right i trust you hit it with more drops.
I been using NR for a couple years now and never checked my NAD levels... might give it a go to see where I actually stand.
Has anyone taken this without being sponsored?
Testing NR vs NMN now unsponsored
Same experience here. Must have been mildly deficient too. Too much missed sleep and poor eating in my 20s.
Everything is just, clearer. It's like yeah there's problems with my body but things seem to be functioning more efficiently.
Just because a compound (you are taking orally) shows up in your blood does not necessarily mean it is doing anything (good) for you!
In general, I agree with that
What happened to you?
Isn't Rapamycin the ultimate longevity molecule?
Probably is! I've seen people reporting some interesting side effects with that though.
For low doses, yes. Not high doses
@@JoeMama-ud5eh maybe I’ll give it a try and make a vid on it.
you must take NMN with TMG
Not necessarily.
Nmn taps from your methyl groups, so you make some tmg, but depending on how much Nmn your taking, it might be good to supplement with tmg as a,precaution to prevent methyl groups from getting low. It’s cheap and doesn’t hurt. Maybe take tmg at night if you take Nmn in the morning so the Nmn has a good bank to work with.
Really good to know!
Guess you are dead now?
Yes. Took too much NMN 😅
cut all the filler and this would be much better
That’s what skipping and chapters are for ✌️👍
if your viewers have to skip three quarters of your content that's probably a good indication there is too much filler in your content... @@Project.Andrew
@@harmankardon478 that’s the beauty of free will. If you want to watch, you can. If you don’t want to watch you don’t have to ✌️👌
very true! and explains why your view count and subs are low. if you listened to constructive feedback, you would be doing better. @@Project.Andrew
@@harmankardon478 ehh, that’s not very nice 😂
its too bad , your channel had the most potential I have ever seen and then this. Oh well, you will likely make more money off supplements anyways. You are a little young and very early in your channel for a video like this.
??? NMN is as legit as supplements get idk why youre acting like this is some snake oil
I knew I’d get a few comments like this. Because of that I was a bit reluctant to make the video.
But I went ahead with it because I was able to show that it worked for me, and the company has high standards (3rd party tested, TGA regulated).
I wish you could see the number of sponsors I’ve turned down that are actually selling snake oil.
@@Project.Andrewyou’ll never please everyone. Keep doing what you’re doing 🤘
In this world there are those who create and those who can not, so their only way of trying to obtain any recognition is to try and destroy. As humans, we often are affected more by the negative giving it our attention. This is a survival mechanism, but it is important at a point to just tell those MFs to F... off and get a life. Carry on doing what you are doing mate. You are a creator, not a loser.