Andrew Huberman, we appreciate you for bringing important health advice to the entire humanity for free. You have helped billions of people improve their health and life at zero cost. You are a great human being I ❤ you.
I appreciate the perspective based on personal experience. I feel so many people in mainstream podcasts have forgotten to speak just on subjective basis. It almost seemed like this was perceived as unprofessional, which isn't the case. We have bio-individuality. Personal experience matters. ✌🏻✨
Do a blood test, check your levels. Do a list yourself. If you are not out of optimal healthy levels. Do not supplement or change your lifestyle. Simple.
Well, all vitamins are S tier. And for minerals Magnesium and Sodium are key which many people aren't getting enough of, I could name all of them but a quick Google search would show the ones you need.
@@flameguy3416 I was supplementing magnesium, I tested a week after stopping my supliment and it was over healthy levels and I was supplementing half the daily requirements... To be over optimal range is quite high as it has a fair amount of flexibility... This forced my body to raise my pH levels too high.. again... Blood test... See what "you" need. Then change lifestyle. Don't ask Google what "most" people don't get. When was the last time you had a blood test to see these things? You think most other people have too? Where is the data showing that most people have low magnesium? It's a fad. Check your levels.
I'm currently taking NMN and resverateol (12 days so far) and I feel significantly more energised and alert. I'm also following other protocols that may impact on that, but since adding these sups to my regime, I've felt better for sure.
I had my first NAD IV last night. We started the drip very slow. About every 20 minutes we’d increase. The last 10 minutes we floored it and I felt my stomach almost like butterflies. Slightly uncomfortable but not bad at all. A little head pressure, not bad at all. I researched about the discomfort and ate a meal before my injection. That may have helped significantly. The nurse mentioned I took it faster and better than most she sees and I believe it’s due to eating before. I will go 1x week 5 weeks then determine if I want to continue 1x monthly indefinitely. It’s also nice getting the vitamins and glutathione pushes.
I can only speak from personal experience but since I started taking sublingual NMN around 2 years ago, I haven't gotten sick once. I also get that more constant level of energy that you mentioned as well.
Renue by science is a great brand, I take it at around 1.5 g a day, amazing energy and youthful skin appearance, grey hairs going away, whatever it’s doing I like it
Hi Andrew! Are you able to do a podcast specifically on pregnancy protocols? You’ve done some great podcasts with tangential topics (fertility, hormones, etc.), but doing a full episode on what women who are newly pregnant need to know, consider, and can do for protocols would be amazing! I know a lot of my friends have plenty of book recommendations but a succinct podcast from you on the topic covering all the literature would be awesome. I’ll bookmark it for when my family starts to expand and make sure to share to all my currently expanding friend’s families! Thanks for everything!
Thank you, Dr. Huberman, for all the important information you shared. I have a question about all the supplements that I took every day (about a year ago). I took my thyroid pill with pycnogenol and collagen in the morning or mid-morning. I waited about an hour or two, and then I took NMN, Resveratrol, TMG, Berberin, and Fisetin. I usually ate my breakfast in the afternoon, sometimes in the evening!😅 Before my first meal of the day, I will take CA-Akg and Apigenin and follow with my day time vitamins, ( Multi, A, B-Complex, C, E, Taurine, Astaxanthin and Alpha Lipoic Acid ) after my first meal. In the evening, one hour before dinner, I will take NMN and TMG again. Then, after dinner, ( my evening vitamins are calcium, magnesium, omega 3, Co Q 10, zinc, and K2-D3. PLEASE HELP ADVICE, IF ALL THESE SUPPLEMENTS I AM TAKING ARE ABOUT THE RIGHT TIMING TAKING TOGETHER? 🤔😓 ( I AM 72 YRS, YOUNG). I WILL GREATLY APPRECIATE IT FOR YOUR RESPONSE. THANK YOU VERY, VERY MUCH. 🙏💕 Love your shows.
I’ve been wanting to try NMN and NR for the mental energy and clarity, along with the mitochondrial benefits, being that I’m always tired and have chronic illness.
Thankyou for broadcasting this information. As I recall many of the supplements discussed were seen more positively around a year ago, and it is good to know the latest interpretations of the latest and best information.
I think genetics play a part, too. I have severe heart disease in my family. Dad died young and same as his mom, my grandma. Someone in our family smoked 2 pkgs a day for 47 yrs. They eat really healthy vegetables and lean meat .At their angioplasty, the surgeon looked over and said its a good thing you never smoked. They said i did for 47 yrs.The surgeon said, "What do you eat? You do not have 1 single blockage at 85 ,so their diet was incredible and only person in family with perfect heart.
@romescala_aban3125 Yes, it's bizarre because they did smoke for 47 yrs, 80 pounds overweight, female,and never exercised or did sports. Sedentary lifestyle, so it was surprising,although diet is excellent and maybe 3 glasses of wine a year. She drank well water,would go for a walk yes,but not regular exercise and TBH I think she's lived so long because she has zero stress,eats no sugar, the odd dessert and a lot of vegetables. I think stress really is a huge factor. She's had 12 children as well.
Would have liked a word about nicotinic acid as a substitute for NR/NMN, since some people say, NMN NR both are mostly broken down to nicotinic acid anyways.
I have heard Dr Ford Brewer and others take up to 2 grams a day YIKES I assume they built up to it. Certainly a lot less expensive and some people are not convinced about NAD/NMN supplementation. I hadn’t heard of sublingual NMN til now hmmmm
A question about the physiological sigh: Is there any difference between inhaling into your diaphram and inhaling into your lungs? In Qi Gong you learn to expand your diaphram first to inhale as much oxygen as possible before you start inhaling into your lungs but here you often repeat that the second inhale is all about expanding your lungs. I would love to hear more about fhe science of inhalation. Also how important is the sound of the sigh, sometimes when you do it it sounds different, does it make a difference and is it important to make an “Aaahhh” sound when exhaling? Thank you Dr Huberman for all your amazing work, you are a constant source of inspiration! 🤍
Hi Andrew! Could you please do a deep dive research on Transcendental Meditation? There are lots of controversy around this meditation method and the validity of the research papers around it. Thank you so much!
Seconding here AH’s rationale for NMN/NR supplementation. The longevity question is for the future to decide, but this (speaking of NMN only in my experience) provides an immediate non-jittery boost to physical and mental energy. Shame it’s not more widely available 😤
Regarding working through trauma (big and little) . . . in addition to psychiatrists and psychologists, there are many excellent licensed clinical counselors and social workers that do this work. I'd like to hear an interview discussion on EMDR therapy, ideally with Francine Shapiro, PhD, the originator of EMDR.
Hello Andrew, I really enjoy your podcast. I recently read a research article about how modern hunter-gatherers have virtually zero cases of acne. I think it would be interesting to hear an episode on skin health and aging etc. perhaps bring on an expert on skin
Whoever told you this is either ignorant, idiot or a scammer. That's simply not true and there won't be an episode because there's just no science based evidence to support it on a wider scale. The question should be asked what supplements,etc can be used for skin. That's a question that can actually be answered with science and facts which is currently available and there are many who take those for improved skin conditions.
@flameguy3416 I'm 50 years old. When these run out I am thinking about trying a diferent supplement called MitoPure. I have an autoimmune disorder called psoriatic arthritis and anything that helps with energy or modulating inflamation I'm willing to try.
I’m interested specifically increased longevity and health-span for women with thyroid dysfunction. Can’t help but think, if researched, would have unique recommendations, if scientifically researched. Do any of these studies with these compounds, differentiate between the two unique hormone profiles of the male and females?
i didn't get discomfort with NAD+ IV, i let it go in over a couple of hours relaxing and it was fine. i wondered if it was because my body was already acclimatised to me taking NMN and B3. good energy uplift in the context of post viral fatigue. but expensive to do frequently.
I have a comment on importance to follow levels of NAD+ upon supplementation. It allows to connect subjective feeling of energy burst with objective measure from the blood. We all are different in the way we utilise different NAD+ precursors and increase in NAD+ will be sensed in subjected manner. What I mean is that, for example, for one person level of NAD+ in blood has to reach 45 uM to feel energy boost while for another 35 uM will make a difference. It brings us to necessity to measure NAD+ and NADH in blood to get better understanding of one well-being. NADMED kits enable measurement both metabolites from blood. Another comment about your highlight of importance of physical exercise. It also should have its contribution on NAD metabolism, like enhance NADH oxidation and result in shifts of dynamic NAD+/NADH ratio.
So mr. Huberman. I do have a very healthy lifestyle diet etc. only 25 but I do NMN as well. After I tried it once and went off it I did notice a big drop in energy. My goal is to live a very long healthy life. I also do creatine and the gym twice a week at least. Also eat 1 or 2 whole cloves once a day.
I have taken NMN for a year, did not notice a significant change in terms of energy. I also agree that NAD iv's is very uncomfortable and decreasing infussion rate helped.
Why no love for David Sinclair? When you interviewed him a year or so ago, you seemed really enamored and interested in his longevity research and subsequently the pills he recommended.
Lots of longevity researchers don’t fully agree with David Sinclair’s work. I never worked on longevity per se, but I read some of his famous papers while I worked on NAD biosynthesis. I am also skeptical of some of his claims.
@@peroxisome1 One thing that made me skeptical is after I started seeing Dr. Sinclair on every podcast everywhere. It seems like he will accept an interview on anyone’s podcast/channel, regardless of the quality/audience. That fact alone made me think, how in the world does he have enough time to stay on a road show all the time? And next I started thinking, is he doing this just to raise awareness and therefore funding for his lab?
Yeah I’ve been taking NMN and Resveratrol for a couple of years, not really noticing massive everyday differences but assume that I was contributing to my longevity and playing the long game. Disappointing news really as when Andrew had David Sinclair on he seemed to agree with all his points and I was under the impression that Sinclair had presented sufficient evidence to prove that the combination had longevity benefits?
@@philsmith7927 science keeps changing as we replicate (or try and fail to replicate data). You did not harm yourself by taking NMN or resveratol if you stuck to advised dosage. It’s good to change/get better with time.
Thank you for this useful info. I've been taking NMN and Resveritrol for about 2 months, every day. this stuff makes me feel so great I can't believe it) Clarity, energy, and deep calm. I'm addicted!
@@BlsblsblsI take Resvertrol myself and I take a brand by Natural Factors. This works amazing for my legs and my severe allergies caused by inflammation markers due to multiple factors
Dr. Huberman thank you for this candid discussion. I was recently diagnosed with beginning glaucoma. You are the perfect person to ask this: Does NR help with reducing progression of glaucoma to your knowledge? 🤔
I survived two types of cancer in the past 25 years. Recently I’ve got excited about supplementation for longevity. After watching several videos of your podcast I signed up Inside Tracker. I’m 73 but fairly healthy. I wonder if I should start NMN along with resveratrol.
PLEASE do an episode on EPILEPSY! I have temporal lobe epilepsy and I want to know why my focal aware seizures cause derealization. Also why the overall experience is so terrifying even though the individual sensations aren’t all that bad.
@kimberyn my husband has epilepsy (partial focals that go into generalized tonic clonics). I’d also love Dr. Huberman to do a podcast on Epilepsy and what can be done to improve symptoms! My husband suffers from horrible migraines, but has been controlled on his meds. Sending you big hugs and I’m sorry your seizures are so terrifying!!! 💜💜💜💜
I have taken NMN and Resveratrol for 14 months now. I love them both for the energy and focus they give me, except they make me really hungry all the time. That is the only part of it I do not like.
Hello Dr., my name is Debra Brunett and I’m a 70 year old female. I watch you a Lot! Also watch others. I am searching for a discussion on if it possible to come back to a state of personal independence, my condition was a fatty liver that crossed the threshold about 18 months ago during the pandemic into cirrhosis with a few nodes! I admit that I feel betrayed by the medical community. Yes I was told that I had fatty liver and in 2017 the ketogenic diet became my lifestyle. I didn’t live on butter and bacon either. In addition am highly inflamed with osteoarthritis in the spine and the right hip is bone on bone, I was taken off pain medication with only Tylenol 4xs a day. It didn’t make the pain bearable, I found by laying on my side in bed the pain was bearable so since 2017 pain management has been laying in bed. Now walking is a problem is this something I can heal and why is chronic pain not being treated or discussed and I hear about fatty liver but not cirrhosis, people seem to think it’s not a problem! Mental health, I am not going to say anything but it dire. Ageism has given me a expiration date. I will die very pissed off at the clown show corporate medicine care that is a pay of this country! I do hold out hope for someone that has something to offer hope.
Dr. Huberman, I love your videos and I would love to show them to my mom but she only speaks Spanish. I was wondering if you were interested in getting your videos translated or if you already had something in works. Thank you for all the hard work you do, making this information easy to understand and accessible to general population.
Something Dr. Charles Brenner mentions all the time is how it's only NR that gets into tissue outside the blood. He has done deep dives around the mechanisms on his Twitter a number of times. Please have him on!
@@stanislavp1739 NAD+ cannot be metabolized in the stomach. That is why it's usually injected. What you want orally are NAD precursors like NR. NR has the ability to enter cells directly where NAD+ can be synthesized. NMN does not.
@@stanislavp1739 NMM cannot enter cells directly. It **must be"* converted to NR before entering cells. NR is by far the most studied precursor. There's no good reason to go with NMM over NR. Literally zero.
I’ve been taking BASIS from Elysium health for about 6 years. In my fifties and literally have less white hair now than when I started. Now, I can find a couple :)
I’d love to hear why not use niacin or your thoughts on niacin for NAD boost. It’s much more well researched over many more years and is a very effective increase in NAD
I've been taking them daily since the beginning of the pandemic. I've been feeling great, full of energy, and overall healthy. Of course I can't definitely attribute it to these supplements, since I've been doing more of other "healthy" things too (e.g. intermittent fasting)
Hi Andrew. How about more info on women like my my wife Kelly -a 58 year old. Specifically, hormones , menopause, weight gain near the waist. She is working out and working hard to keep in shape but we would love your thoughts. We feel this is right in your wheelhouse! Please explain hot flashes! The more technical the better. Let’s gets this explained for people like us. Thank you so much !!!!!!!
Taking a low dose of NMN besides positives, most likely upregulated my aromatase. My whole life I used to have low estradiol proportionally to testosterone - 15 e2 to 1000 t. Although, a couple of weekeks in taking NMN, the ratio changed to about 50 e2 to 1000 t. That's a significant change and it persists even after 2 months aftet stopping NMN. The caviat is I'm taking exogenous testosterone, but I've been doing it for many years and the only changed variable recently was the addition of NMN
Please comment on taurine and NAC in the episode on supplements you are preparing! Your negative opinion on these is a mystery that bugs many people. Info on other longevity supplements like quercetin would be cool as well. :)
the "physionic" channel has some really good things on both taurine and NAC. Both are no-brainers in my lay opinion. Listening to Nick go through the research is highly convincing. Both are supportive of optimal health, especially as we age.
Thank goodness for this AMA ❤ Perfect timing. I have been taking 2500-5000 mg of creatine and 500 mg of L-tyrosine and the combination has been so helpful! Is it bad to take the L-Tyrosine each day if i find it helpful without any noted side effects? I noted you don’t take L-tyrosine everyday. I recently am having memory and what I would call cognitive flow trouble. This has been the most helpful change I have made (added to all the other good stuff/habits already adopted - sleep, sunlight, exercise etc).
NMN has concerns around causing cancer and also depleting your body’s own ability to make NAD. I only take it rarely for this reason until their is more literature on this
I've been taking NMN and Resveratrol for nearly 12 months and feel no difference. I wanted to give it 12 months but seeing as energy is still low and I'm healthy dont drink or smoke and regularly exercise . Will be stopping after I finish the current bottles. All I got was expensive pee
So my daughter, who is 34… Has asked me about nmn , if she should start supplementing with it. I know typically this diminishes at least by 50% by the age of 50 but our younger people taking it now rapid cell turnover as well??
Please, please some info on how we can incorporate weight training into our regimen when dealing with very painful fibromyalgia and chronic fatigue syndrome. Need some help here!
I tried NAD infusions, I would say it takes a few hours,if somebody do it, pkease do it really really slowly, one drop per minute to make it tolerable, otherwise it feels awful. TAD infusions also help to increase energy and physical performance or liposomal gluthatione as an oral spray.
It's kind of disappointing that he doesn't acknowledge that anything strengthening and protecting the vascular system would help long term health/longevity.
Would you be willing to discuss repetitive head trauma and all of its effects on the brain and body? Especially pertaining to its effect on testosterone, and maybe ways to treat it?
I'll opt for the inexpensive non-flushing B3, which won't cause drowsiness, while the flushing type tends to induce sleepiness. Take the flushing B3 supplement in the evening and the non-flushing one in the morning.
Thank you, as always, for your guidance. What are your thoughts on using a high potency broad-spectrum micronutrient formulation vs. single supplements in order to ‘fill’ any known/unknown deficits and to avoid unintentionally causing deficits by picking/choosing what to take/not take.
I have read an article saying that NR can increase possibility of getting or spreading cancer. Is there any good data on this? I feel great after taking this supplement, but I am a bit worried now.
I would love to see your take on Low dose Lithium orotate for memory, alzheimers, dementia, adhd (agression and frustration) suicide rates, brain fog after Covid 19 infection or the vaccine for it, among other potential benefits. I realize the small studies are not definitive but there is a ton of annecdotal evidence showing benefits in all these areas and more.
If you have already discussed this can someone please link the episode? I was wondering if you have mentioned sinuses and if there's a way of fixing blocked sinuses other than saline washouts and surgery?
If you would consider making a video on individuals with sleep disorders, more specifically narcolepsy, and how to potentially maximize quality of life with such condition, it would be appreciated more than you know.
What about taking daily M&M’s? I’ve been including this in my program and I have heard it’s not good for you but I will likely continue regardless. The main reason is that M&M’s are delicious.
I suffer from MDD. I heard about resveratrol so I ordered it. I don't know if I can say the brand name but I can say what is written on the label: 200mg resveratrol (root extract from Polygonum cuspidatum), 12.5mg poliphenols from vitis vinifera (red wine) and 46 mg poliphenols from vitis vinifera seeds. I too one pill 3 hours ago, empty stomach, it was 10 a.m. Well, aftet 45minutes I started feeling a 'warm sensation' to my brain. Like a calming, anti anxiety effect, and more focused. It's similar to bdz effect but without that foggy brain sensation. I'm also feeling, after 3 hours, that this calming effect is fading away. I will continue with 1 pill a day as reported on the label. I also noticed a strong antidepressant effect with another supplement. It's L-arginine containing also liposomial vitamin c. To feel the antidepressant effect I have to take 2 vials, each one containing 500 mg liposomial vitamin c plus an 1.66g of arginine, with a time distance of two hours between the two vials. It also makes my emicrania and my aching bones desappear. This is my personal exerience and I don't want to suggest anything to anyone because everyone has a personal health story and has to know if that supplement can be taken by him/her also looking to potential side effects, but maybe some researchers who can read this can have a feedback by someone who suffers from MDD with atypical symptoms such as hypersomnia, hyperphagia etc. Thank you Andrew Huberman. I really respect you a lot. Sorry for my 'not perfect english. I'm not a native speaker'.
Please please make a video about autism. So many parents are desperate for trustable treatment. They spend so many money on unproven therapies and supplements. There is so much confusing data about: Diets Supplementation Neurofeedback Microbiom testing HBOT for autism. Thank you
Hello Dr Huberman and his fans from Uzbekistan 🇺🇿.
Thank you for useful podcasts!
Thank you for all that you do for this world.
Andrew Huberman, we appreciate you for bringing important health advice to the entire humanity for free.
You have helped billions of people improve their health and life at zero cost.
You are a great human being I ❤ you.
Thank you so much for your honesty and generosity. Your wealth of knowledge is incredible, and you provide this for free to the world. Thank you. ❤
I appreciate the perspective based on personal experience. I feel so many people in mainstream podcasts have forgotten to speak just on subjective basis. It almost seemed like this was perceived as unprofessional, which isn't the case. We have bio-individuality. Personal experience matters. ✌🏻✨
A tier list of vitamins and minerals would be awesome
Do a blood test, check your levels. Do a list yourself. If you are not out of optimal healthy levels. Do not supplement or change your lifestyle. Simple.
Also supplements are processed so if you can get them in your diet (which most healthy people can) do that first.
@@Bubzy118I personally think processed goods are great. I'll take acetaminophen over tree bark tea.
Blood work is a great call though.
Well, all vitamins are S tier. And for minerals Magnesium and Sodium are key which many people aren't getting enough of, I could name all of them but a quick Google search would show the ones you need.
@@flameguy3416 I was supplementing magnesium, I tested a week after stopping my supliment and it was over healthy levels and I was supplementing half the daily requirements... To be over optimal range is quite high as it has a fair amount of flexibility... This forced my body to raise my pH levels too high.. again... Blood test... See what "you" need. Then change lifestyle. Don't ask Google what "most" people don't get. When was the last time you had a blood test to see these things? You think most other people have too? Where is the data showing that most people have low magnesium? It's a fad. Check your levels.
I'm currently taking NMN and resverateol (12 days so far) and I feel significantly more energised and alert. I'm also following other protocols that may impact on that, but since adding these sups to my regime, I've felt better for sure.
NR has more benefits evidenced by human studies. Most of NMN studies are limited to have animal subjects.
What brand and what dose are you taking ?
@Josh-ql3be Could you please tell what brand? I take it too but not sure how I feel about it. Maybe I will consider different brands
@yuliiavoinova484 I take Neutrality
I had my first NAD IV last night. We started the drip very slow. About every 20 minutes we’d increase. The last 10 minutes we floored it and I felt my stomach almost like butterflies. Slightly uncomfortable but not bad at all. A little head pressure, not bad at all. I researched about the discomfort and ate a meal before my injection. That may have helped significantly. The nurse mentioned I took it faster and better than most she sees and I believe it’s due to eating before. I will go 1x week 5 weeks then determine if I want to continue 1x monthly indefinitely. It’s also nice getting the vitamins and glutathione pushes.
You are really helping yourself if you watch this man.
I can only speak from personal experience but since I started taking sublingual NMN around 2 years ago, I haven't gotten sick once. I also get that more constant level of energy that you mentioned as well.
I have been taking almost 4 years. Deathly sick from coronavirus twice in that time. Anecdotal evidence is the lowest form of evidence.
Can you still buy this? What brand?
I use Renue NMN
@@valerie71 not on Amazon... nr and Nad no nmn
Renue by science is a great brand, I take it at around 1.5 g a day, amazing energy and youthful skin appearance, grey hairs going away, whatever it’s doing I like it
Love the idea of you putting out what you take!
I would love to see a whole podcast of Dr Huberman about longevity supplements such as NMN ,NR,apigenin,spermedin
Hi Andrew! Are you able to do a podcast specifically on pregnancy protocols? You’ve done some great podcasts with tangential topics (fertility, hormones, etc.), but doing a full episode on what women who are newly pregnant need to know, consider, and can do for protocols would be amazing! I know a lot of my friends have plenty of book recommendations but a succinct podcast from you on the topic covering all the literature would be awesome. I’ll bookmark it for when my family starts to expand and make sure to share to all my currently expanding friend’s families! Thanks for everything!
I second that! Great idea!
Yes! I am in the process of transitioning and the first thing I plan to do is get pregnant.
That is not his field honey.
Thanks!
Thank you, Dr. Huberman, for all the important information you shared. I have a question about all the supplements that I took every day (about a year ago). I took my thyroid pill with pycnogenol and collagen in the morning or mid-morning. I waited about an hour or two, and then I took NMN, Resveratrol, TMG, Berberin, and Fisetin. I usually ate my breakfast in the afternoon, sometimes in the evening!😅 Before my first meal of the day, I will take CA-Akg and Apigenin and follow with my day time vitamins, ( Multi, A, B-Complex, C, E, Taurine, Astaxanthin and Alpha Lipoic Acid ) after my first meal. In the evening, one hour before dinner, I will take NMN and TMG again. Then, after dinner, ( my evening vitamins are calcium, magnesium, omega 3, Co Q 10, zinc, and K2-D3. PLEASE HELP ADVICE, IF ALL THESE SUPPLEMENTS I AM TAKING ARE ABOUT THE RIGHT TIMING TAKING TOGETHER? 🤔😓 ( I AM 72 YRS, YOUNG). I WILL GREATLY APPRECIATE IT FOR YOUR RESPONSE. THANK YOU VERY, VERY MUCH. 🙏💕 Love your shows.
Hi Dr Huberman, what brand NMN and NR do you personally use?
25:45 quality social connections, eliminating toxic people
This should be #1!
When I eliminated toxic people I lost social connections 🤣
I truly enjoy the way you speak! Thanks for sharing so much information. 😊
Thanks for the straight answer about resveratrol.
I’ve been wanting to try NMN and NR for the mental energy and clarity, along with the mitochondrial benefits, being that I’m always tired and have chronic illness.
NMN is worth investing in. My energy levels feel elevated for sure.
@@Marc-gregorywhat brand
Thankyou for broadcasting this information. As I recall many of the supplements discussed were seen more positively around a year ago, and it is good to know the latest interpretations of the latest and best information.
I love your podcast. Thank you.
Love your podcast’s research-based information! Thank you.
I think genetics play a part, too. I have severe heart disease in my family. Dad died young and same as his mom, my grandma. Someone in our family smoked 2 pkgs a day for 47 yrs. They eat really healthy vegetables and lean meat .At their angioplasty, the surgeon looked over and said its a good thing you never smoked. They said i did for 47 yrs.The surgeon said, "What do you eat? You do not have 1 single blockage at 85 ,so their diet was incredible and only person in family with perfect heart.
Yes genes , age, sex , weight , blood profile ..factors to consider ..
@romescala_aban3125 Yes, it's bizarre because they did smoke for 47 yrs, 80 pounds overweight, female,and never exercised or did sports. Sedentary lifestyle, so it was surprising,although diet is excellent and maybe 3 glasses of wine a year. She drank well water,would go for a walk yes,but not regular exercise and TBH I think she's lived so long because she has zero stress,eats no sugar, the odd dessert and a lot of vegetables. I think stress really is a huge factor. She's had 12 children as well.
Would have liked a word about nicotinic acid as a substitute for NR/NMN, since some people say, NMN NR both are mostly broken down to nicotinic acid anyways.
There's some risks/side effects with nicotinic acid
I have heard Dr Ford Brewer and others take up to 2 grams a day YIKES I assume they built up to it. Certainly a lot less expensive and some people are not convinced about NAD/NMN supplementation. I hadn’t heard of sublingual NMN til now hmmmm
A question about the physiological sigh:
Is there any difference between inhaling into your diaphram and inhaling into your lungs?
In Qi Gong you learn to expand your diaphram first to inhale as much oxygen as possible before you start inhaling into your lungs but here you often repeat that the second inhale is all about expanding your lungs. I would love to hear more about fhe science of inhalation.
Also how important is the sound of the sigh, sometimes when you do it it sounds different, does it make a difference and is it important to make an “Aaahhh” sound when exhaling?
Thank you Dr Huberman for all your amazing work, you are a constant source of inspiration! 🤍
Hi Andrew! Could you please do a deep dive research on Transcendental Meditation? There are lots of controversy around this meditation method and the validity of the research papers around it. Thank you so much!
Seconding here AH’s rationale for NMN/NR supplementation. The longevity question is for the future to decide, but this (speaking of NMN only in my experience) provides an immediate non-jittery boost to physical and mental energy. Shame it’s not more widely available 😤
Regarding working through trauma (big and little) . . . in addition to psychiatrists and psychologists, there are many excellent licensed clinical counselors and social workers that do this work. I'd like to hear an interview discussion on EMDR therapy, ideally with Francine Shapiro, PhD, the originator of EMDR.
What about mushrooms? Reishi, Lions Mane, Turkey tail..
I take those plus 4 other mushrooms daily. I put a table spoon in my coffee.
Hello Andrew, I really enjoy your podcast.
I recently read a research article about how modern hunter-gatherers have virtually zero cases of acne. I think it would be interesting to hear an episode on skin health and aging etc. perhaps bring on an expert on skin
And ... The hype on castor oils in organic form cold pressed?
For skin and hair, but to boost vision and some organ functions ????
Whoever told you this is either ignorant, idiot or a scammer. That's simply not true and there won't be an episode because there's just no science based evidence to support it on a wider scale. The question should be asked what supplements,etc can be used for skin. That's a question that can actually be answered with science and facts which is currently available and there are many who take those for improved skin conditions.
Less/no sugar more sunlight - minimal acne.
I take an NAD+ supplement as well as a NAC supplement. I take them for the energy boost I feel when I take it.
How old are you? I'm not sure it's even worth it if you're under 30 since you're not really slowing down at that stage of life.
@flameguy3416 I'm 50 years old. When these run out I am thinking about trying a diferent supplement called MitoPure.
I have an autoimmune disorder called psoriatic arthritis and anything that helps with energy or modulating inflamation I'm willing to try.
I’m interested specifically increased longevity and health-span for women with thyroid dysfunction. Can’t help but think, if researched, would have unique recommendations, if scientifically researched. Do any of these studies with these compounds, differentiate between the two unique hormone profiles of the male and females?
It's a crisis. Miserable health and unable to start a family.😢
Thanks for sharing, very much anticipating your personal supplement list.
i didn't get discomfort with NAD+ IV, i let it go in over a couple of hours relaxing and it was fine. i wondered if it was because my body was already acclimatised to me taking NMN and B3. good energy uplift in the context of post viral fatigue. but expensive to do frequently.
I have a comment on importance to follow levels of NAD+ upon supplementation. It allows to connect subjective feeling of energy burst with objective measure from the blood. We all are different in the way we utilise different NAD+ precursors and increase in NAD+ will be sensed in subjected manner. What I mean is that, for example, for one person level of NAD+ in blood has to reach 45 uM to feel energy boost while for another 35 uM will make a difference. It brings us to necessity to measure NAD+ and NADH in blood to get better understanding of one well-being. NADMED kits enable measurement both metabolites from blood. Another comment about your highlight of importance of physical exercise. It also should have its contribution on NAD metabolism, like enhance NADH oxidation and result in shifts of dynamic NAD+/NADH ratio.
So mr. Huberman. I do have a very healthy lifestyle diet etc. only 25 but I do NMN as well. After I tried it once and went off it I did notice a big drop in energy. My goal is to live a very long healthy life. I also do creatine and the gym twice a week at least. Also eat 1 or 2 whole cloves once a day.
I have taken NMN for a year, did not notice a significant change in terms of energy. I also agree that NAD iv's is very uncomfortable and decreasing infussion rate helped.
Since this is an 'Ask me anything', can you paint my house?
And can I watch??
I think I'm qualified to answer for him. The answer is No.😊
I feel like somehow we would learn so much from watching him do it!
I’m sure he likely can, but I doubt he will. Haha.
I can paint your house.
Why no love for David Sinclair? When you interviewed him a year or so ago, you seemed really enamored and interested in his longevity research and subsequently the pills he recommended.
Lots of longevity researchers don’t fully agree with David Sinclair’s work. I never worked on longevity per se, but I read some of his famous papers while I worked on NAD biosynthesis. I am also skeptical of some of his claims.
yes i also remember that Dr.Huberman said different things about metformin etc
@@peroxisome1 One thing that made me skeptical is after I started seeing Dr. Sinclair on every podcast everywhere. It seems like he will accept an interview on anyone’s podcast/channel, regardless of the quality/audience. That fact alone made me think, how in the world does he have enough time to stay on a road show all the time? And next I started thinking, is he doing this just to raise awareness and therefore funding for his lab?
Yeah I’ve been taking NMN and Resveratrol for a couple of years, not really noticing massive everyday differences but assume that I was contributing to my longevity and playing the long game. Disappointing news really as when Andrew had David Sinclair on he seemed to agree with all his points and I was under the impression that Sinclair had presented sufficient evidence to prove that the combination had longevity benefits?
@@philsmith7927 science keeps changing as we replicate (or try and fail to replicate data). You did not harm yourself by taking NMN or resveratol if you stuck to advised dosage. It’s good to change/get better with time.
Thank you for this useful info. I've been taking NMN and Resveritrol for about 2 months, every day. this stuff makes me feel so great I can't believe it) Clarity, energy, and deep calm. I'm addicted!
Hello, which brand do you use please ? Thank you for your sharing
Yes. What brand and what dose please
@@BlsblsblsI take Resvertrol myself and I take a brand by Natural Factors. This works amazing for my legs and my severe allergies caused by inflammation markers due to multiple factors
@@texasjmdtry Natural Factors super strength 500mg
Dr. Huberman thank you for this candid discussion. I was recently diagnosed with beginning glaucoma. You are the perfect person to ask this: Does NR help with reducing progression of glaucoma to your knowledge? 🤔
I would love to know too for someone on the borderline with a strong family history.
I survived two types of cancer in the past 25 years. Recently I’ve got excited about supplementation for longevity. After watching several videos of your podcast I signed up Inside Tracker. I’m 73 but fairly healthy. I wonder if I should start NMN along with resveratrol.
PLEASE do an episode on EPILEPSY!
I have temporal lobe epilepsy and I want to know why my focal aware seizures cause derealization. Also why the overall experience is so terrifying even though the individual sensations aren’t all that bad.
Try cbg rich hemp oil
@kimberyn my husband has epilepsy (partial focals that go into generalized tonic clonics). I’d also love Dr. Huberman to do a podcast on Epilepsy and what can be done to improve symptoms! My husband suffers from horrible migraines, but has been controlled on his meds. Sending you big hugs and I’m sorry your seizures are so terrifying!!! 💜💜💜💜
Try resvertrol bc this is a powerful anti-inflammatory
I have taken NMN and Resveratrol for 14 months now. I love them both for the energy and focus they give me, except they make me really hungry all the time. That is the only part of it I do not like.
What brand and what daily dose are you using
Hello Dr., my name is Debra Brunett and I’m a 70 year old female. I watch you a Lot! Also watch others. I am searching for a discussion on if it possible to come back to a state of personal independence, my condition was a fatty liver that crossed the threshold about 18 months ago during the pandemic into cirrhosis with a few nodes! I admit that I feel betrayed by the medical community. Yes I was told that I had fatty liver and in 2017 the ketogenic diet became my lifestyle. I didn’t live on butter and bacon either. In addition am highly inflamed with osteoarthritis in the spine and the right hip is bone on bone, I was taken off pain medication with only Tylenol 4xs a day. It didn’t make the pain bearable, I found by laying on my side in bed the pain was bearable so since 2017 pain management has been laying in bed. Now walking is a problem is this something I can heal and why is chronic pain not being treated or discussed and I hear about fatty liver but not cirrhosis, people seem to think it’s not a problem! Mental health, I am not going to say anything but it dire. Ageism has given me a expiration date. I will die very pissed off at the clown show corporate medicine care that is a pay of this country! I do hold out hope for someone that has something to offer hope.
Dr. Huberman, I love your videos and I would love to show them to my mom but she only speaks Spanish. I was wondering if you were interested in getting your videos translated or if you already had something in works. Thank you for all the hard work you do, making this information easy to understand and accessible to general population.
Thank you Dr Huberman! I'm seeing a lot of NR supplements w/ Resveratrol. Is there any benefit to taking the two together?
Something Dr. Charles Brenner mentions all the time is how it's only NR that gets into tissue outside the blood. He has done deep dives around the mechanisms on his Twitter a number of times. Please have him on!
oral NAD+ doesn't get into cells?
@@stanislavp1739 NAD+ cannot be metabolized in the stomach. That is why it's usually injected. What you want orally are NAD precursors like NR. NR has the ability to enter cells directly where NAD+ can be synthesized. NMN does not.
@@HORNGEN4 thank you. I thought NAD+ absorber in stomach like collagen peptides. I wonder why people have good results from NMN then?
@@stanislavp1739 NMM cannot enter cells directly. It **must be"* converted to NR before entering cells. NR is by far the most studied precursor. There's no good reason to go with NMM over NR. Literally zero.
@@stanislavp1739 they are lying or its placebo. Nmn and reservatrol are scam supps
I’ve been taking BASIS from Elysium health for about 6 years. In my fifties and literally have less white hair now than when I started. Now, I can find a couple :)
How much do you take a day
I’d love to hear why not use niacin or your thoughts on niacin for NAD boost. It’s much more well researched over many more years and is a very effective increase in NAD
How many supplements do you take Andrew?
After reading David Sinclair’s book, I took Resveratrol and NMN for more than six months. I was hopeful but saw no changes so stopped taking both!
I did. Workouts exploded
@@trojanesc awesome testimonial 😅
You may live longer. You will never know.
I've been taking them daily since the beginning of the pandemic. I've been feeling great, full of energy, and overall healthy. Of course I can't definitely attribute it to these supplements, since I've been doing more of other "healthy" things too (e.g. intermittent fasting)
Resveratrol and nmn just another scam supplements
Thank you for this
Hi Andrew. How about more info on women like my my wife Kelly -a 58 year old. Specifically, hormones , menopause, weight gain near the waist. She is working out and working hard to keep in shape but we would love your thoughts. We feel this is right in your wheelhouse! Please explain hot flashes! The more technical the better. Let’s gets this explained for people like us. Thank you so much !!!!!!!
Thanks for the clear summary which is in line with my exprience
Taking a low dose of NMN besides positives, most likely upregulated my aromatase. My whole life I used to have low estradiol proportionally to testosterone - 15 e2 to 1000 t. Although, a couple of weekeks in taking NMN, the ratio changed to about 50 e2 to 1000 t. That's a significant change and it persists even after 2 months aftet stopping NMN. The caviat is I'm taking exogenous testosterone, but I've been doing it for many years and the only changed variable recently was the addition of NMN
Please comment on taurine and NAC in the episode on supplements you are preparing! Your negative opinion on these is a mystery that bugs many people. Info on other longevity supplements like quercetin would be cool as well. :)
the "physionic" channel has some really good things on both taurine and NAC. Both are no-brainers in my lay opinion. Listening to Nick go through the research is highly convincing. Both are supportive of optimal health, especially as we age.
It surprised me you didn't mention GlyNAC which is probably the best researched compound with regards to extending healthspan.
Surprised me to, that and Taurine. I find normal L-cysteine with glycine suits me better than NA Cysteine/glycine (Glynac)
Do you test your biomarkers (blood panel, metabolic panel, lipid panel, hormones, NAD, etc)? If so, what was the before and after?
Thank goodness for this AMA ❤ Perfect timing. I have been taking 2500-5000 mg of creatine and 500 mg of L-tyrosine and the combination has been so helpful! Is it bad to take the L-Tyrosine each day if i find it helpful without any noted side effects? I noted you don’t take L-tyrosine everyday. I recently am having memory and what I would call cognitive flow trouble. This has been the most helpful change I have made (added to all the other good stuff/habits already adopted - sleep, sunlight, exercise etc).
NMN has concerns around causing cancer and also depleting your body’s own ability to make NAD. I only take it rarely for this reason until their is more literature on this
Those concerns were largely proved false in several animal model studies
@@donkramer8848 true but it’s mouse studies, not humans. Not saying it’s bad, just would benefit from some clinical trials
¡Hola Profe!Thank You for Your hard work. It's truly appreciated by all of us.
I've been taking NMN and Resveratrol for nearly 12 months and feel no difference. I wanted to give it 12 months but seeing as energy is still low and I'm healthy dont drink or smoke and regularly exercise . Will be stopping after I finish the current bottles. All I got was expensive pee
Where do you get NMN?
So my daughter, who is 34… Has asked me about nmn , if she should start supplementing with it. I know typically this diminishes at least by 50% by the age of 50 but our younger people taking it now rapid cell turnover as well??
Thank you 🌹
Hello 👋👋
What do you think of high doses of niacyn? 2-3 grams daily.
So which brand are you taking if NMN were banned?
Thanks.
I'm curious about your thoughts on Taurine for life span and niacin for also increases NAD.
Ty for covering longevity ❤
Wondering One can be on TRT while simultaneously on Medication for anxiety like Cipralex and Welbutrin?
TRT IS NATTY BRO. YUR FINE.
Please, please some info on how we can incorporate weight training into our regimen when dealing with very painful fibromyalgia and chronic fatigue syndrome. Need some help here!
Most of this goes directly contrary to most comments made by David Sinclair, who was on your podcast.
Don’t trust everything Sinclair says.
probably because new research came in and he adapted to the new data
I have tried both nmn and nr, nmn works better for me.
Are you able to tell us what brands you use of NR and NMN
Doing a 500 mg NAD+ infusion now as we speak. They arnt so bad if you infuse slowly. Results totally worth it.
Fantastic episode, thank you
I tried NAD infusions, I would say it takes a few hours,if somebody do it, pkease do it really really slowly, one drop per minute to make it tolerable, otherwise it feels awful. TAD infusions also help to increase energy and physical performance or liposomal gluthatione as an oral spray.
You should interview Cindy teevens! She has mastered understanding of the mind. No one out there is sharing what she is 🙏
How do you explain the French paradox if not for the effects of resveratrol in red wine?
It's kind of disappointing that he doesn't acknowledge that anything strengthening and protecting the vascular system would help long term health/longevity.
Would you be willing to discuss repetitive head trauma and all of its effects on the brain and body? Especially pertaining to its effect on testosterone, and maybe ways to treat it?
Dr. Huberman, do you take TMG with NMN in 1:1 ratio?
Which brand should we purchase from
Thank you very much for your valuable information ♥👍👍
I'll opt for the inexpensive non-flushing B3, which won't cause drowsiness, while the flushing type tends to induce sleepiness.
Take the flushing B3 supplement in the evening and the non-flushing one in the morning.
Non flushing type only helps with lipids and nothing else
I’m the kind of person who asks anything 🙌🙌🙌🤣
Thank you, as always, for your guidance. What are your thoughts on using a high potency broad-spectrum micronutrient formulation vs. single supplements in order to ‘fill’ any known/unknown deficits and to avoid unintentionally causing deficits by picking/choosing what to take/not take.
I have read an article saying that NR can increase possibility of getting or spreading cancer. Is there any good data on this? I feel great after taking this supplement, but I am a bit worried now.
I would love to see your take on Low dose Lithium orotate for memory, alzheimers, dementia, adhd (agression and frustration) suicide rates, brain fog after Covid 19 infection or the vaccine for it, among other potential benefits. I realize the small studies are not definitive but there is a ton of annecdotal evidence showing benefits in all these areas and more.
If you have already discussed this can someone please link the episode? I was wondering if you have mentioned sinuses and if there's a way of fixing blocked sinuses other than saline washouts and surgery?
Any Dr K fans on here? We need a Dr K - Huberhomie collab soon!
If you would consider making a video on individuals with sleep disorders, more specifically narcolepsy, and how to potentially maximize quality of life with such condition, it would be appreciated more than you know.
Can you share your views on Blueprint by Bryan Johnson?
What about taking daily M&M’s? I’ve been including this in my program and I have heard it’s not good for you but I will likely continue regardless. The main reason is that M&M’s are delicious.
NAD IVY 100mg drastically reduced arthritis pain in my knee
Instead of Bill Nye The Science Guy, we have Andrew Huberman The Science Uberman!
I suffer from MDD. I heard about resveratrol so I ordered it. I don't know if I can say the brand name but I can say what is written on the label: 200mg resveratrol (root extract from Polygonum cuspidatum), 12.5mg poliphenols from vitis vinifera (red wine) and 46 mg poliphenols from vitis vinifera seeds. I too one pill 3 hours ago, empty stomach, it was 10 a.m. Well, aftet 45minutes I started feeling a 'warm sensation' to my brain. Like a calming, anti anxiety effect, and more focused. It's similar to bdz effect but without that foggy brain sensation. I'm also feeling, after 3 hours, that this calming effect is fading away. I will continue with 1 pill a day as reported on the label. I also noticed a strong antidepressant effect with another supplement. It's L-arginine containing also liposomial vitamin c. To feel the antidepressant effect I have to take 2 vials, each one containing 500 mg liposomial vitamin c plus an 1.66g of arginine, with a time distance of two hours between the two vials. It also makes my emicrania and my aching bones desappear. This is my personal exerience and I don't want to suggest anything to anyone because everyone has a personal health story and has to know if that supplement can be taken by him/her also looking to potential side effects, but maybe some researchers who can read this can have a feedback by someone who suffers from MDD with atypical symptoms such as hypersomnia, hyperphagia etc. Thank you Andrew Huberman. I really respect you a lot. Sorry for my 'not perfect english. I'm not a native speaker'.
Please please make a video about autism. So many parents are desperate for trustable treatment. They spend so many money on unproven therapies and supplements.
There is so much confusing data about:
Diets
Supplementation
Neurofeedback
Microbiom testing
HBOT
for autism.
Thank you
I can’t find his supplement list, can someone share if they have it?