AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory
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- เผยแพร่เมื่อ 31 พ.ค. 2024
- Welcome to a preview of the 12th Ask Me Anything (AMA) episode, part of Huberman Lab Premium.
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Timestamps
00:00:00 Introduction
00:01:46 Resveratrol and Longevity Supplements
00:26:49 Huberman Lab Premium
In the full AMA episode, we discuss:
- What Is Working Memory and How to Improve It
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Hello Dr Huberman and his fans from Uzbekistan 🇺🇿.
Thank you for useful podcasts!
Thank you for all that you do for this world.
I appreciate the perspective based on personal experience. I feel so many people in mainstream podcasts have forgotten to speak just on subjective basis. It almost seemed like this was perceived as unprofessional, which isn't the case. We have bio-individuality. Personal experience matters. ✌🏻✨
Love the idea of you putting out what you take!
Thank you so much for your honesty and generosity. Your wealth of knowledge is incredible, and you provide this for free to the world. Thank you. ❤
I truly enjoy the way you speak! Thanks for sharing so much information. 😊
Thankyou for broadcasting this information. As I recall many of the supplements discussed were seen more positively around a year ago, and it is good to know the latest interpretations of the latest and best information.
I can only speak from personal experience but since I started taking sublingual NMN around 2 years ago, I haven't gotten sick once. I also get that more constant level of energy that you mentioned as well.
I have been taking almost 4 years. Deathly sick from coronavirus twice in that time. Anecdotal evidence is the lowest form of evidence.
Can you still buy this? What brand?
I use Renue NMN
@@valerie71 not on Amazon... nr and Nad no nmn
Renue by science is a great brand, I take it at around 1.5 g a day, amazing energy and youthful skin appearance, grey hairs going away, whatever it’s doing I like it
Andrew Huberman, we appreciate you for bringing important health advice to the entire humanity for free.
You have helped billions of people improve their health and life at zero cost.
You are a great human being I ❤ you.
A tier list of vitamins and minerals would be awesome
Do a blood test, check your levels. Do a list yourself. If you are not out of optimal healthy levels. Do not supplement or change your lifestyle. Simple.
Also supplements are processed so if you can get them in your diet (which most healthy people can) do that first.
@@Bubzy118I personally think processed goods are great. I'll take acetaminophen over tree bark tea.
Blood work is a great call though.
Well, all vitamins are S tier. And for minerals Magnesium and Sodium are key which many people aren't getting enough of, I could name all of them but a quick Google search would show the ones you need.
@@flameguy3416 I was supplementing magnesium, I tested a week after stopping my supliment and it was over healthy levels and I was supplementing half the daily requirements... To be over optimal range is quite high as it has a fair amount of flexibility... This forced my body to raise my pH levels too high.. again... Blood test... See what "you" need. Then change lifestyle. Don't ask Google what "most" people don't get. When was the last time you had a blood test to see these things? You think most other people have too? Where is the data showing that most people have low magnesium? It's a fad. Check your levels.
I would love to see a whole podcast of Dr Huberman about longevity supplements such as NMN ,NR,apigenin,spermedin
I love your podcast. Thank you.
Thanks for sharing, very much anticipating your personal supplement list.
Thanks for the straight answer about resveratrol.
Hi Andrew! Are you able to do a podcast specifically on pregnancy protocols? You’ve done some great podcasts with tangential topics (fertility, hormones, etc.), but doing a full episode on what women who are newly pregnant need to know, consider, and can do for protocols would be amazing! I know a lot of my friends have plenty of book recommendations but a succinct podcast from you on the topic covering all the literature would be awesome. I’ll bookmark it for when my family starts to expand and make sure to share to all my currently expanding friend’s families! Thanks for everything!
I second that! Great idea!
Yes! I am in the process of transitioning and the first thing I plan to do is get pregnant.
Thank you for this useful info. I've been taking NMN and Resveritrol for about 2 months, every day. this stuff makes me feel so great I can't believe it) Clarity, energy, and deep calm. I'm addicted!
Thank you, Dr. Huberman, for all the important information you shared. I have a question about all the supplements that I took every day (about a year ago). I took my thyroid pill with pycnogenol and collagen in the morning or mid-morning. I waited about an hour or two, and then I took NMN, Resveratrol, TMG, Berberin, and Fisetin. I usually ate my breakfast in the afternoon, sometimes in the evening!😅 Before my first meal of the day, I will take CA-Akg and Apigenin and follow with my day time vitamins, ( Multi, A, B-Complex, C, E, Taurine, Astaxanthin and Alpha Lipoic Acid ) after my first meal. In the evening, one hour before dinner, I will take NMN and TMG again. Then, after dinner, ( my evening vitamins are calcium, magnesium, omega 3, Co Q 10, zinc, and K2-D3. PLEASE HELP ADVICE, IF ALL THESE SUPPLEMENTS I AM TAKING ARE ABOUT THE RIGHT TIMING TAKING TOGETHER? 🤔😓 ( I AM 72 YRS, YOUNG). I WILL GREATLY APPRECIATE IT FOR YOUR RESPONSE. THANK YOU VERY, VERY MUCH. 🙏💕 Love your shows.
You are really helping yourself if you watch this man.
Love your podcast’s research-based information! Thank you.
Thank goodness for this AMA ❤ Perfect timing. I have been taking 2500-5000 mg of creatine and 500 mg of L-tyrosine and the combination has been so helpful! Is it bad to take the L-Tyrosine each day if i find it helpful without any noted side effects? I noted you don’t take L-tyrosine everyday. I recently am having memory and what I would call cognitive flow trouble. This has been the most helpful change I have made (added to all the other good stuff/habits already adopted - sleep, sunlight, exercise etc).
I'm currently taking NMN and resverateol (12 days so far) and I feel significantly more energised and alert. I'm also following other protocols that may impact on that, but since adding these sups to my regime, I've felt better for sure.
what about tmg?
NR has more benefits evidenced by human studies. Most of NMN studies are limited to have animal subjects.
Fantastic episode, thank you
Thanks for the clear summary which is in line with my exprience
Ty for covering longevity ❤
I’ve been wanting to try NMN and NR for the mental energy and clarity, along with the mitochondrial benefits, being that I’m always tired and have chronic illness.
NMN is worth investing in. My energy levels feel elevated for sure.
I truly enjoy listening to you I wish I could meet you in person. I lived in the bay area at french youth center as a kid I think you're in the bay area I feel like a lot of these tools Would be so beneficial for youth growing up in the system I lived through a lot of different types of stressful situations I feel like your tools are so beneficial For everyone from every walk a life
Thank you for this
A question about the physiological sigh:
Is there any difference between inhaling into your diaphram and inhaling into your lungs?
In Qi Gong you learn to expand your diaphram first to inhale as much oxygen as possible before you start inhaling into your lungs but here you often repeat that the second inhale is all about expanding your lungs. I would love to hear more about fhe science of inhalation.
Also how important is the sound of the sigh, sometimes when you do it it sounds different, does it make a difference and is it important to make an “Aaahhh” sound when exhaling?
Thank you Dr Huberman for all your amazing work, you are a constant source of inspiration! 🤍
Thank you very much for your valuable information ♥👍👍
I survived two types of cancer in the past 25 years. Recently I’ve got excited about supplementation for longevity. After watching several videos of your podcast I signed up Inside Tracker. I’m 73 but fairly healthy. I wonder if I should start NMN along with resveratrol.
i didn't get discomfort with NAD+ IV, i let it go in over a couple of hours relaxing and it was fine. i wondered if it was because my body was already acclimatised to me taking NMN and B3. good energy uplift in the context of post viral fatigue. but expensive to do frequently.
Thank you, as always, for your guidance. What are your thoughts on using a high potency broad-spectrum micronutrient formulation vs. single supplements in order to ‘fill’ any known/unknown deficits and to avoid unintentionally causing deficits by picking/choosing what to take/not take.
¡Hola Profe!Thank You for Your hard work. It's truly appreciated by all of us.
Dr. Huberman thank you for this candid discussion. I was recently diagnosed with beginning glaucoma. You are the perfect person to ask this: Does NR help with reducing progression of glaucoma to your knowledge? 🤔
I would love to know too for someone on the borderline with a strong family history.
Would have liked a word about nicotinic acid as a substitute for NR/NMN, since some people say, NMN NR both are mostly broken down to nicotinic acid anyways.
There's some risks/side effects with nicotinic acid
I have heard Dr Ford Brewer and others take up to 2 grams a day YIKES I assume they built up to it. Certainly a lot less expensive and some people are not convinced about NAD/NMN supplementation. I hadn’t heard of sublingual NMN til now hmmmm
I take an NAD+ supplement as well as a NAC supplement. I take them for the energy boost I feel when I take it.
Which brand you take ?
Thank you 🌹
Hello 👋👋
So mr. Huberman. I do have a very healthy lifestyle diet etc. only 25 but I do NMN as well. After I tried it once and went off it I did notice a big drop in energy. My goal is to live a very long healthy life. I also do creatine and the gym twice a week at least. Also eat 1 or 2 whole cloves once a day.
Hi Andrew! Could you please do a deep dive research on Transcendental Meditation? There are lots of controversy around this meditation method and the validity of the research papers around it. Thank you so much!
Regarding working through trauma (big and little) . . . in addition to psychiatrists and psychologists, there are many excellent licensed clinical counselors and social workers that do this work. I'd like to hear an interview discussion on EMDR therapy, ideally with Francine Shapiro, PhD, the originator of EMDR.
You should interview Cindy teevens! She has mastered understanding of the mind. No one out there is sharing what she is 🙏
I love your videos.
I’m interested specifically increased longevity and health-span for women with thyroid dysfunction. Can’t help but think, if researched, would have unique recommendations, if scientifically researched. Do any of these studies with these compounds, differentiate between the two unique hormone profiles of the male and females?
It's a crisis. Miserable health and unable to start a family.😢
Dr. Huberman, I love your videos and I would love to show them to my mom but she only speaks Spanish. I was wondering if you were interested in getting your videos translated or if you already had something in works. Thank you for all the hard work you do, making this information easy to understand and accessible to general population.
Thank you Dr Huberman! I'm seeing a lot of NR supplements w/ Resveratrol. Is there any benefit to taking the two together?
If you have already discussed this can someone please link the episode? I was wondering if you have mentioned sinuses and if there's a way of fixing blocked sinuses other than saline washouts and surgery?
Taking a low dose of NMN besides positives, most likely upregulated my aromatase. My whole life I used to have low estradiol proportionally to testosterone - 15 e2 to 1000 t. Although, a couple of weekeks in taking NMN, the ratio changed to about 50 e2 to 1000 t. That's a significant change and it persists even after 2 months aftet stopping NMN. The caviat is I'm taking exogenous testosterone, but I've been doing it for many years and the only changed variable recently was the addition of NMN
25:45 quality social connections, eliminating toxic people
This should be #1!
When I eliminated toxic people I lost social connections 🤣
Hello Andrew, I really enjoy your podcast.
I recently read a research article about how modern hunter-gatherers have virtually zero cases of acne. I think it would be interesting to hear an episode on skin health and aging etc. perhaps bring on an expert on skin
And ... The hype on castor oils in organic form cold pressed?
For skin and hair, but to boost vision and some organ functions ????
Whoever told you this is either ignorant, idiot or a scammer. That's simply not true and there won't be an episode because there's just no science based evidence to support it on a wider scale. The question should be asked what supplements,etc can be used for skin. That's a question that can actually be answered with science and facts which is currently available and there are many who take those for improved skin conditions.
Less/no sugar more sunlight - minimal acne.
+1 for the future list of your supplements along with the rationale behind each one 👍
Hi Dr Huberman, what brand NMN and NR do you personally use?
What about mushrooms? Reishi, Lions Mane, Turkey tail..
I have taken NMN for a year, did not notice a significant change in terms of energy. I also agree that NAD iv's is very uncomfortable and decreasing infussion rate helped.
Thanks!
PLEASE do an episode on EPILEPSY!
I have temporal lobe epilepsy and I want to know why my focal aware seizures cause derealization. Also why the overall experience is so terrifying even though the individual sensations aren’t all that bad.
Try cbg rich hemp oil
Hello Dr., my name is Debra Brunett and I’m a 70 year old female. I watch you a Lot! Also watch others. I am searching for a discussion on if it possible to come back to a state of personal independence, my condition was a fatty liver that crossed the threshold about 18 months ago during the pandemic into cirrhosis with a few nodes! I admit that I feel betrayed by the medical community. Yes I was told that I had fatty liver and in 2017 the ketogenic diet became my lifestyle. I didn’t live on butter and bacon either. In addition am highly inflamed with osteoarthritis in the spine and the right hip is bone on bone, I was taken off pain medication with only Tylenol 4xs a day. It didn’t make the pain bearable, I found by laying on my side in bed the pain was bearable so since 2017 pain management has been laying in bed. Now walking is a problem is this something I can heal and why is chronic pain not being treated or discussed and I hear about fatty liver but not cirrhosis, people seem to think it’s not a problem! Mental health, I am not going to say anything but it dire. Ageism has given me a expiration date. I will die very pissed off at the clown show corporate medicine care that is a pay of this country! I do hold out hope for someone that has something to offer hope.
Thanks for the usual great video. Somehow I caused a serious case of mussel wasting in my legs. Decreasing Mtore is my main suspect. At age 72 protein synthesis is reduced. I have increased food and protein intake with anti-carcinogens such as tumeric currcumin and others. My condition is improving slowly. I am now very suspect of fasting or any other methods of anti aging that decrease Mtore. Any thoughts on this?
Hello Andrew, it would be very helpful if you could do an episode on joint health.
For Nsdr to be effective does it need to be a pre recorded script? Sometimes I do more of a self directed body scan and I’m curious if that lessens the effectiveness because my mind is thinking more about what to scan next and such. Would love to hear more about types of scripts and which are more effective
I’d love to hear why not use niacin or your thoughts on niacin for NAD boost. It’s much more well researched over many more years and is a very effective increase in NAD
Which brand should we purchase from
Hi Andrew, Love your pod casts. Have just founds them. Have you done any pod casts on mtor and its possible anti aging effects?
Hii
I have tried both nmn and nr, nmn works better for me.
Holy are u ever blasting the NAD boosters! Good to know. ❤
What do you think of high doses of niacyn? 2-3 grams daily.
Please comment on taurine and NAC in the episode on supplements you are preparing! Your negative opinion on these is a mystery that bugs many people. Info on other longevity supplements like quercetin would be cool as well. :)
I have a comment on importance to follow levels of NAD+ upon supplementation. It allows to connect subjective feeling of energy burst with objective measure from the blood. We all are different in the way we utilise different NAD+ precursors and increase in NAD+ will be sensed in subjected manner. What I mean is that, for example, for one person level of NAD+ in blood has to reach 45 uM to feel energy boost while for another 35 uM will make a difference. It brings us to necessity to measure NAD+ and NADH in blood to get better understanding of one well-being. NADMED kits enable measurement both metabolites from blood. Another comment about your highlight of importance of physical exercise. It also should have its contribution on NAD metabolism, like enhance NADH oxidation and result in shifts of dynamic NAD+/NADH ratio.
What can you do to help with back problems I e help with lumber and discs ,
I get a lot of pain and have mutipal bulging and a Ruptured disc ,
I have recently stopped having g so many pain killers and started having sup s ( nmn resveratrol sea moss red krill vit d k2 sometimes shilajit ) and cold dip s and saunas which are helping along with swimming . Is there anything Specific for discs you can advise , many thanks .
For about how long did the vitality boost of IV NAD last? Did the following day see a return to previous day's baseline or a stepped-up basis? Basically, what did the window of effect look like?
Hi Huberman! Just wanted to request your review of C15 (fatty15) for longevity and its other claims. Thanks for your great information!
We need to hear more about NR.
Wondering One can be on TRT while simultaneously on Medication for anxiety like Cipralex and Welbutrin?
TRT IS NATTY BRO. YUR FINE.
What do you think of conjugated linoleic acid supplements and their conversion to nitro-CLA. The CLA react rapidly with nitric oxide, and the nitro fatty acids are potent antiinflammatories.
What is your take on taking quality Selenium supplements up to 400 mcg/day for known better health issues/Adults? Thanks
Can you explain tachykinin a bit more? Does it create a new baseline or change the threshold for socializing?
Hi Andrew. How about more info on women like my my wife Kelly -a 58 year old. Specifically, hormones , menopause, weight gain near the waist. She is working out and working hard to keep in shape but we would love your thoughts. We feel this is right in your wheelhouse! Please explain hot flashes! The more technical the better. Let’s gets this explained for people like us. Thank you so much !!!!!!!
I'm curious about your thoughts on Taurine for life span and niacin for also increases NAD.
Hi Andrew. First of all thank you so much for all your podcasts. I am a regular listener. I had an experience with NAD that seems to be unusual and anyone familiar with NAD says it couldn't have been the NAD. I did the infusions (probably 3) and had a terrible headache. (I hardly ever get headaches.) I stopped the infusions (no more headache) and started taking NMN. A year or so later I took the NAD nasal spray and got a headache. Can you tell me anything about why this would happen? Cheers, Laurie
Try and take TMG along with NAD boosters. At least 2gm if you are taking large amounts or infusions. It helps me.
@@tatiananikolskaya6991 Thanks for your reply. Not sure what TMG is. I will not take NAD boosters or infusions again. I'll listen to my body. I'm happy with NMN. My question is why do you think the NAD causes headaches.
I’ve been taking BASIS from Elysium health for about 6 years. In my fifties and literally have less white hair now than when I started. Now, I can find a couple :)
Any thoughts about the new product TRU? It claims to have the research. Thank you!
NAD IVY 100mg drastically reduced arthritis pain in my knee
Since you mentioned you have no affiliation
What brand of NMN and NR do you take?
Others reading this, what brands are 3rd party tested?
Thank You
Something Dr. Charles Brenner mentions all the time is how it's only NR that gets into tissue outside the blood. He has done deep dives around the mechanisms on his Twitter a number of times. Please have him on!
oral NAD+ doesn't get into cells?
@@stanislavp1739 NAD+ cannot be metabolized in the stomach. That is why it's usually injected. What you want orally are NAD precursors like NR. NR has the ability to enter cells directly where NAD+ can be synthesized. NMN does not.
@@HORNGEN4 thank you. I thought NAD+ absorber in stomach like collagen peptides. I wonder why people have good results from NMN then?
@@stanislavp1739 NMM cannot enter cells directly. It **must be"* converted to NR before entering cells. NR is by far the most studied precursor. There's no good reason to go with NMM over NR. Literally zero.
@@stanislavp1739 they are lying or its placebo. Nmn and reservatrol are scam supps
Why no love for David Sinclair? When you interviewed him a year or so ago, you seemed really enamored and interested in his longevity research and subsequently the pills he recommended.
Lots of longevity researchers don’t fully agree with David Sinclair’s work. I never worked on longevity per se, but I read some of his famous papers while I worked on NAD biosynthesis. I am also skeptical of some of his claims.
yes i also remember that Dr.Huberman said different things about metformin etc
@@peroxisome1 One thing that made me skeptical is after I started seeing Dr. Sinclair on every podcast everywhere. It seems like he will accept an interview on anyone’s podcast/channel, regardless of the quality/audience. That fact alone made me think, how in the world does he have enough time to stay on a road show all the time? And next I started thinking, is he doing this just to raise awareness and therefore funding for his lab?
Yeah I’ve been taking NMN and Resveratrol for a couple of years, not really noticing massive everyday differences but assume that I was contributing to my longevity and playing the long game. Disappointing news really as when Andrew had David Sinclair on he seemed to agree with all his points and I was under the impression that Sinclair had presented sufficient evidence to prove that the combination had longevity benefits?
@@philsmith7927 science keeps changing as we replicate (or try and fail to replicate data). You did not harm yourself by taking NMN or resveratol if you stuck to advised dosage. It’s good to change/get better with time.
Instead of Bill Nye The Science Guy, we have Andrew Huberman The Science Uberman!
Inside Tracker does not provide a UK service. What do we use if in the UK? Thanks
Most of this goes directly contrary to most comments made by David Sinclair, who was on your podcast.
Don’t trust everything Sinclair says.
probably because new research came in and he adapted to the new data
I suffer from MDD. I heard about resveratrol so I ordered it. I don't know if I can say the brand name but I can say what is written on the label: 200mg resveratrol (root extract from Polygonum cuspidatum), 12.5mg poliphenols from vitis vinifera (red wine) and 46 mg poliphenols from vitis vinifera seeds. I too one pill 3 hours ago, empty stomach, it was 10 a.m. Well, aftet 45minutes I started feeling a 'warm sensation' to my brain. Like a calming, anti anxiety effect, and more focused. It's similar to bdz effect but without that foggy brain sensation. I'm also feeling, after 3 hours, that this calming effect is fading away. I will continue with 1 pill a day as reported on the label. I also noticed a strong antidepressant effect with another supplement. It's L-arginine containing also liposomial vitamin c. To feel the antidepressant effect I have to take 2 vials, each one containing 500 mg liposomial vitamin c plus an 1.66g of arginine, with a time distance of two hours between the two vials. It also makes my emicrania and my aching bones desappear. This is my personal exerience and I don't want to suggest anything to anyone because everyone has a personal health story and has to know if that supplement can be taken by him/her also looking to potential side effects, but maybe some researchers who can read this can have a feedback by someone who suffers from MDD with atypical symptoms such as hypersomnia, hyperphagia etc. Thank you Andrew Huberman. I really respect you a lot. Sorry for my 'not perfect english. I'm not a native speaker'.
I'll opt for the inexpensive non-flushing B3, which won't cause drowsiness, while the flushing type tends to induce sleepiness.
Take the flushing B3 supplement in the evening and the non-flushing one in the morning.
Non flushing type only helps with lipids and nothing else
NR or NMN? wich one is the best option? whats the recomended dose? why are they so expensive?
I tried NAD infusions, I would say it takes a few hours,if somebody do it, pkease do it really really slowly, one drop per minute to make it tolerable, otherwise it feels awful. TAD infusions also help to increase energy and physical performance or liposomal gluthatione as an oral spray.
I would love to see your take on Low dose Lithium orotate for memory, alzheimers, dementia, adhd (agression and frustration) suicide rates, brain fog after Covid 19 infection or the vaccine for it, among other potential benefits. I realize the small studies are not definitive but there is a ton of annecdotal evidence showing benefits in all these areas and more.
I've been taking NMN and Resveratrol for nearly 12 months and feel no difference. I wanted to give it 12 months but seeing as energy is still low and I'm healthy dont drink or smoke and regularly exercise . Will be stopping after I finish the current bottles. All I got was expensive pee
Where do you get NMN?
It surprised me you didn't mention GlyNAC which is probably the best researched compound with regards to extending healthspan.
Surprised me to, that and Taurine. I find normal L-cysteine with glycine suits me better than NA Cysteine/glycine (Glynac)
How many supplements do you take Andrew?
I have read an article saying that NR can increase possibility of getting or spreading cancer. Is there any good data on this? I feel great after taking this supplement, but I am a bit worried now.
David Sinclair bamboozled his way to a big payday.
Please, what do you mean by that? Is he scamming people?
I wouldn’t say scamming, but don’t trust everything he sells.
Yes he is a scammer
Dr david sinclair says to take 500 mg per day of resveratrol. What do you say about this?
I’m the kind of person who asks anything 🙌🙌🙌🤣
What about taking daily M&M’s? I’ve been including this in my program and I have heard it’s not good for you but I will likely continue regardless. The main reason is that M&M’s are delicious.