Ok, I’m listening and I really like what he is saying and taking it to heart, and this is why I really appreciate functional medicine doctors, and even don’t trust many traditional doctors. (That’s not just a feeling. The number of times my Dad has been misdiagnosed is ridiculous. They were going to put him on levothyroxine for low thyroid, and then by chance, the hospital gave a magnesium infusion during a battle with sepsis - and that fixed his thyroid.) I’ll go start growing my broccoli sprouts again. But, not to get distracted, I LOVE his sweater and necklace.
Multiple studies, including one done by the ITP, have demonstrated that spermidine levels are not increased in the blood or tissues after ingesting spermidine supplements. See Brad Stanfield's video on the subject.
Then where does it go? When you swallow the spermidine supplements they are in your body. So, it doesn’t make any difference if Brad cannot find any spermidine in the blood. It’s in the body, and that;s a fact Jack. Instead, Silly Boy Brad should be asking is spermidine ingestion causing autophagy? Is spermidine supplements inproving the heart, the brain, and so on. Brad is a complete nay-sayer that is pushing his own vitamin line to make a lot of money.
@@scottk1525 It doesn’t make any difference where it goes. The main thing is does it improve the heart, brain, immune system, and other organs? The research proves that it does.
@@PianoPatterns123 " *It doesn’t make any difference where it goes* " What a silly thing to say. It makes all the difference. If it is not absorbed during digestion and instead just ends up in the toilet bowl, then it hasn't accomplished anything for you, has it? " *The research proves that it does* " What research are you referring to? I certainly haven't seen any research that "proves" this. And I've heard from multiple researchers in the field of nutrition and longevity that there is no causal or interventional evidence supporting dietary spermidine (the two that come to mind are Dr. Stanfield in his videos, and Dr. Gregor in one of his books.) And for what it's worth, the latter and his team reviewed over 20,000 studies on health, nutrition, and longevity for said book. Not to say that it is case closed. But I see strong reason from multiple credible sources to be skeptical of dietary spermidine. And so far no good reason to think it's viable.
@@PianoPatterns123 what a silly thing to say. It makes all the difference where it goes. If it just moves through your digestive system and it's not absorbed and comes out the back of you, then it hasn't done you any good. I've heard from multiple well informed researchers that there is no good evidence supporting dietary spermidine. What evidence do you have that "proves" it improves organs and other systems?
Most NAD+ is a result of the NAD+ salvage pathway. Certain dietary components help preserve the salvage pathway. (e.g. apigenin, quercetin) Good gut health also helps by limiting CD38 which depletes NAD+. Adam Antebi has shown that low insulin raises NMM, a precursor of NAD+ although this has not been fleshed out in human. Low insulin has positive pleotropic effects. As for spermidine, I have yet to see a supplement provide any where close to the amount I get in my diet (mushrooms, beans, etc.) Plus, a bit of daily time restricted eating and avoiding simple carbs goes along way to improving several types of autophagy (ref. work of Ana Maria Cuervo and other researchers) as well as preserving NAD. Not a fan of supplements first and pill pushers - should be last resort for those who can't exercise and eat right
I like your philosophy and align with what you say. Getting nutrients and vitamins through your diet is the ideal and cost-effective method in most cases. But we're deficient in certain things, and supplementing is well worth the cost. I'm following a meditarean diet and am feeling great, but with cheap supplements that give me an extra big dose, it's always tempting as an example, aged garlic, spermidine, and B12 hydroxocobalamin. It's obviously also a question of cost. I'll gladly spend a few dollars daily on high-quality supplements because I don't eat out, smoke, drink, or otherwise waste money. So this money is well spent, and it won't hurt if I spend a few hundred dollars per month on supplements while keeping my body and brain in ideal conditions so that I can avoid sickness, injuries, and the high chance of being unable to work for multiple months until the age of 50.
@@fp1517 I also take a few supplements - Lithium, D3, B12, Selenium, O3, etc. Just so much hype some high priced supplements which may not be needed if one exercises and eats right. We really need reliable blood tests to assess things like NAD+ and spermidine levels, mitochondrial age, etc. in order to know if we need to intervene more or differently.
@@peterz53 yes you're so right. A good diet and frequent exercise work wonders. Combine that with reliable blood work and we'd get to much information on how to optimize our performance. May I ask why you supplement Lithium and Selenium? Heard of it a few times but haven't yet had time to research it. You seem to be quite knowledgable in this field.
Dr Halland, please keep your focus on medicine and leave agriculture to us We, true professionals, are really concerned about the mineral levels on our soil and check it every two years to avoid depletion due to nutrients being exported with the crops The only way of farming that has been proven to cause soil depletion is the Organic, due to their superstitious fear of "chemicals", some as simple as potassium chloride And GMOphobia makes less and less sense every year as genetic modification therapies are here to stay
Do you need to consume spermadine on an empty stomach (fasted) to optimize autophagy, or can you induce the same level of autophagy with spermadine even when fed?
In case your wondering, I take Spermidine on an empty stomach late in the afternoon every day, about 2 hrs before diner. I see lots of positive results and happy with taking Spermidine.
Our Russian Wheat Germ based SPERMIDINE is the most powerful n effective in the world Russian wheat is unique! Much Blessings to All Yuliya Beautiful Rich White Snow Bunny n Digital Nomad ✝️✝️🇷🇺🇷🇺🐰🐇
Exactly. I think it's dishonest to push these supplements when common foods have much more and a bit of time restricted eating, exercise, an avoiding simple carbs does a lot more for autophagy.
@@sncnutrition7118 if anything I’m more energized. Get a good sleep and it helps ease the pain I have In My legs and feet. Spermidine does more positive than the operation I had which did nothing.
(REALLY!!)...You go 4 minutes 23 seconds into a 6 minute 41 second video and then you begin talking about the supplement "SPERMIDINE". Just what kind of time management are you doing here?. The video was about "SPERMIDINE" yet you drag this video on almost until the end of the vi8deo and the reason I even clicked on the video was to hear about "SPERMIDINE" and now I'm pissed that you can't seem to get to the point what a waist.
Saying that a natural sourced compound is better than a synthetic one is suspicious to say the least. If it's the same molecule, it doesn't matter where it came from, the body can't tell the difference
You’re absolutely wrong. A lot of people cannot break down synthetic based supplements. For instance About 45% of the population can’t break down synthetic folic acid and can only take methylated folate, because of the MTHFR gene. Many people gave no idea that they have this gene until they do a test. Taking a synthetic based Folic acid (vs the natural based one ,)for years ….I started getting migraines, Exhaustion aches, inflammation and I didn’t know what it was from and it was from taking synthetic based Folic acid. And you need folic acid to break down other B vitamins for energy and not only was I not getting that energy I was pretty much making myself sick.
@@Gina-yy5fe you are talking about two different molecules, even if they are both considered Folates or Vitamin B9, one is folic acid, the other is methylated folate. if you Google it, they are different molecules. Your example doesn't contradict what I stated in my comment. I don't think methylated folate is used as supplementation in food, but, to make an analogy: Synthetic or natural Methylated Folate would be exactly the same thing. Of course when it comes to nutrients, consuming them with the whole food is always better. But that's not what's being discussed in this video. When it comes to supplements, where there is no food matrix for the nutrient in question, whether the molecule is natural sourced (and extracted) or synthesized, if it's the same molecule, it will do exactly the same thing !
So this is just the matter of terminology - when ppl say “synthetic folate” they refer to Folic acid (that is, not generally occurring naturally) form of folate that is used in supplements and in fortified foods. It is, indeed, quite bad for ppl with MTHFR polymorphism because they can not methylate this form easily. The right form for them would be methylfolate, which is active, methylated form of folic acid. Can it be synthesized too? Yes. Is it synthetic folate? No. So just common confusion with naming.
@@CalumnMcAulay This site is a gold mine for ideas for protocols. Some users there are really good in skimming studies, deducting and linking all kind of mechanisms and theories together while seemingly having a stash of cash to test expensive drugs on themselves.
Genetics loads the gun, lifestyle pulls the trigger. Hence I do not agree with you. A very unhealthy lifestyle will ensure you’ll probably perish a lot sooner than if you had followed a healthy lifestyle. If this were not true then everyone would be safe to smoke, be obese, drink to excess with no worries
So that was a sales pitch for Spermidine Life.
Ok, I’m listening and I really like what he is saying and taking it to heart, and this is why I really appreciate functional medicine doctors, and even don’t trust many traditional doctors. (That’s not just a feeling. The number of times my Dad has been misdiagnosed is ridiculous. They were going to put him on levothyroxine for low thyroid, and then by chance, the hospital gave a magnesium infusion during a battle with sepsis - and that fixed his thyroid.) I’ll go start growing my broccoli sprouts again. But, not to get distracted, I LOVE his sweater and necklace.
Thanks for sharing your thoughts! 🙌
Doctors are human too. Not every plumber fixes your pipes.
Multiple studies, including one done by the ITP, have demonstrated that spermidine levels are not increased in the blood or tissues after ingesting spermidine supplements. See Brad Stanfield's video on the subject.
Then where does it go? When you swallow the spermidine supplements they are in your body. So, it doesn’t make any difference if Brad cannot find any spermidine in the blood. It’s in the body, and that;s a fact Jack. Instead, Silly Boy Brad should be asking is spermidine ingestion causing autophagy? Is spermidine supplements inproving the heart, the brain, and so on. Brad is a complete nay-sayer that is pushing his own vitamin line to make a lot of money.
@@PianoPatterns123 " *Then where does it go?*"
Into the toilet.
@@scottk1525 It doesn’t make any difference where it goes. The main thing is does it improve the heart, brain, immune system, and other organs? The research proves that it does.
@@PianoPatterns123 " *It doesn’t make any difference where it goes* "
What a silly thing to say. It makes all the difference. If it is not absorbed during digestion and instead just ends up in the toilet bowl, then it hasn't accomplished anything for you, has it?
" *The research proves that it does* "
What research are you referring to? I certainly haven't seen any research that "proves" this. And I've heard from multiple researchers in the field of nutrition and longevity that there is no causal or interventional evidence supporting dietary spermidine (the two that come to mind are Dr. Stanfield in his videos, and Dr. Gregor in one of his books.) And for what it's worth, the latter and his team reviewed over 20,000 studies on health, nutrition, and longevity for said book.
Not to say that it is case closed. But I see strong reason from multiple credible sources to be skeptical of dietary spermidine. And so far no good reason to think it's viable.
@@PianoPatterns123 what a silly thing to say. It makes all the difference where it goes. If it just moves through your digestive system and it's not absorbed and comes out the back of you, then it hasn't done you any good.
I've heard from multiple well informed researchers that there is no good evidence supporting dietary spermidine. What evidence do you have that "proves" it improves organs and other systems?
Most NAD+ is a result of the NAD+ salvage pathway. Certain dietary components help preserve the salvage pathway. (e.g. apigenin, quercetin) Good gut health also helps by limiting CD38 which depletes NAD+. Adam Antebi has shown that low insulin raises NMM, a precursor of NAD+ although this has not been fleshed out in human. Low insulin has positive pleotropic effects. As for spermidine, I have yet to see a supplement provide any where close to the amount I get in my diet (mushrooms, beans, etc.) Plus, a bit of daily time restricted eating and avoiding simple carbs goes along way to improving several types of autophagy (ref. work of Ana Maria Cuervo and other researchers) as well as preserving NAD. Not a fan of supplements first and pill pushers - should be last resort for those who can't exercise and eat right
I like your philosophy and align with what you say. Getting nutrients and vitamins through your diet is the ideal and cost-effective method in most cases. But we're deficient in certain things, and supplementing is well worth the cost. I'm following a meditarean diet and am feeling great, but with cheap supplements that give me an extra big dose, it's always tempting as an example, aged garlic, spermidine, and B12 hydroxocobalamin. It's obviously also a question of cost. I'll gladly spend a few dollars daily on high-quality supplements because I don't eat out, smoke, drink, or otherwise waste money. So this money is well spent, and it won't hurt if I spend a few hundred dollars per month on supplements while keeping my body and brain in ideal conditions so that I can avoid sickness, injuries, and the high chance of being unable to work for multiple months until the age of 50.
@@fp1517 I also take a few supplements - Lithium, D3, B12, Selenium, O3, etc. Just so much hype some high priced supplements which may not be needed if one exercises and eats right. We really need reliable blood tests to assess things like NAD+ and spermidine levels, mitochondrial age, etc. in order to know if we need to intervene more or differently.
@@peterz53 yes you're so right. A good diet and frequent exercise work wonders. Combine that with reliable blood work and we'd get to much information on how to optimize our performance. May I ask why you supplement Lithium and Selenium? Heard of it a few times but haven't yet had time to research it. You seem to be quite knowledgable in this field.
Great discussion! Thanks for sharing.
Why do you have to be roght 😅
What do you say about the ITP aborting their spermadine test as mice had not shown any increased absorption after 6 months?
Dr Halland, please keep your focus on medicine and leave agriculture to us
We, true professionals, are really concerned about the mineral levels on our soil and check it every two years to avoid depletion due to nutrients being exported with the crops
The only way of farming that has been proven to cause soil depletion is the Organic, due to their superstitious fear of "chemicals", some as simple as potassium chloride
And GMOphobia makes less and less sense every year as genetic modification therapies are here to stay
Gmophobia makes more and sense as it becomes ubiquitous with no idea of safety
Do you need to consume spermadine on an empty stomach (fasted) to optimize autophagy, or can you induce the same level of autophagy with spermadine even when fed?
In case your wondering, I take Spermidine on an empty stomach late in the afternoon every day, about 2 hrs before diner. I see lots of positive results and happy with taking Spermidine.
Our Russian Wheat Germ based SPERMIDINE is the most powerful n effective in the world Russian wheat is unique! Much Blessings to All Yuliya Beautiful Rich White Snow Bunny n Digital Nomad ✝️✝️🇷🇺🇷🇺🐰🐇
My dirty brain has so many jokes I can make, but I’ll just focus on the presentation. Thank you.
Thanks for watching!
How often do you take it as i do not feel comfortable taking it every day
unfortunately spermidinelife supplement has some of the lowest concentrations of spermidine, with the capsules containing 1mg per two capsules.
Exactly. I think it's dishonest to push these supplements when common foods have much more and a bit of time restricted eating, exercise, an avoiding simple carbs does a lot more for autophagy.
I have some that contains 8mg.
@@katekleinsteuber7652 do you notice anything?
Thanks for sharing, Mohamad.
So is it better to take Spermidine in the morning or at bedtime
I take my Spermidine late in the afternoon about 2 hours before diner same time everyday.
@@mik19mazz Doesn't make you feel relaxed or energized...
@@sncnutrition7118 if anything I’m more energized. Get a good sleep and it helps ease the pain I have In My legs and feet. Spermidine does more positive than the operation I had which did nothing.
If you practice Time Restricted Feeding, possibly the best time would be some hours after you started the fasting
If you have a broken nerve in ear dialing tinnitus can this spermidine regrow or repair broken nerve in ear?
Ive read that psilocybin mushrooms have a chance to jostle the system into a functioning state.
No - I used it spermidine daily - 1 cap - and no changes
I’d look into copper supplements.
(REALLY!!)...You go 4 minutes 23 seconds into a 6 minute 41 second video and then you begin talking about the supplement "SPERMIDINE". Just what kind of time management are you doing here?. The video was about "SPERMIDINE" yet you drag this video on almost until the end of the vi8deo and the reason I even clicked on the video was to hear about "SPERMIDINE" and now I'm pissed that you can't seem to get to the point what a waist.
Wheat germ....
No evidence that this is active orally
Saying that a natural sourced compound is better than a synthetic one is suspicious to say the least. If it's the same molecule, it doesn't matter where it came from, the body can't tell the difference
You’re absolutely wrong. A lot of people cannot break down synthetic based supplements. For instance About 45% of the population can’t break down synthetic folic acid and can only take methylated folate, because of the MTHFR gene. Many people gave no idea that they have this gene until they do a test. Taking a synthetic based Folic acid (vs the natural based one ,)for years ….I started getting migraines, Exhaustion aches, inflammation and I didn’t know what it was from and it was from taking synthetic based Folic acid. And you need folic acid to break down other B vitamins for energy and not only was I not getting that energy I was pretty much making myself sick.
@@Gina-yy5fe you are talking about two different molecules, even if they are both considered Folates or Vitamin B9, one is folic acid, the other is methylated folate. if you Google it, they are different molecules. Your example doesn't contradict what I stated in my comment.
I don't think methylated folate is used as supplementation in food, but, to make an analogy:
Synthetic or natural Methylated Folate would be exactly the same thing.
Of course when it comes to nutrients, consuming them with the whole food is always better. But that's not what's being discussed in this video.
When it comes to supplements, where there is no food matrix for the nutrient in question, whether the molecule is natural sourced (and extracted) or synthesized, if it's the same molecule, it will do exactly the same thing !
Great discussion!
So this is just the matter of terminology - when ppl say “synthetic folate” they refer to Folic acid (that is, not generally occurring naturally) form of folate that is used in supplements and in fortified foods. It is, indeed, quite bad for ppl with MTHFR polymorphism because they can not methylate this form easily. The right form for them would be methylfolate, which is active, methylated form of folic acid. Can it be synthesized too? Yes. Is it synthetic folate? No. So just common confusion with naming.
How can anyone comment on the efficacy of any longevity treatment? It's BS...come back in 40.years and then we'll know
Animal testing can be done in a far shorter timespan. Mice, specifically. Whether the results can be transferred to humans, though...
Some people can treat themselves and try to measure their success with age tests. Have you seen the interesting results on the longecity forum?
@@thomasmuller1850 no I have not...I will probably check it out.
@@CalumnMcAulay This site is a gold mine for ideas for protocols. Some users there are really good in skimming studies, deducting and linking all kind of mechanisms and theories together while seemingly having a stash of cash to test expensive drugs on themselves.
@@CalumnMcAulay I have been studying nutrition for 50 years. If you are not then I guess we won't see you later.
daily Cheddar
It about quality of life but not increasing lifespan
You date of death is determined prior to your birth !!!
Genetics loads the gun, lifestyle pulls the trigger. Hence I do not agree with you. A very unhealthy lifestyle will ensure you’ll probably perish a lot sooner than if you had followed a healthy lifestyle. If this were not true then everyone would be safe to smoke, be obese, drink to excess with no worries
Indeed, Somnambulist!
Wrong.