KarXT (Cobenfy): The Antipsychotic that Could Be a Game Changer
ฝัง
- เผยแพร่เมื่อ 9 ก.พ. 2025
- KarXT, brand name Cobenfy, is the newest antipsychotic medication on the market and is a combination of xanomeline and trospium chloride. It uses a different mechanism of action than what we are used to, targeting muscarinic receptors instead of dopaminergic ones. So today, join me as I talk about how we think KarXT works, the studies that got us to where we are today, and then end on my opinions on taking it as someone with a schizophrenia spectrum illness called schizoaffective disorder.
Enjoy :)
Sources used in this video (and a few other good things to take a look at):
ARTICLES/PODCASTS:
The FDA’s Piece on it: www.fda.gov/ne...
An article in TIME: time.com/70243...
A short podcast episode about it: www.thecarlatr...
JOURNAL ARTICLES (Including the available results from the EMERGENT Trials):
Azargoonjahromi A. (2024). Current Findings and Potential Mechanisms of KarXT (Xanomeline-Trospium) in Schizophrenia Treatment. Clinical drug investigation, 44(7), 471-493. doi.org/10.100...
Bodick, N. C., Offen, W. W., Levey, A. I., Cutler, N. R., Gauthier, S. G., Satlin, A., Shannon, H. E., Tollefson, G. D., Rasmussen, K., Bymaster, F. P., Hurley, D. J., Potter, W. Z., & Paul, S. M. (1997). Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease. Archives of neurology, 54(4), 465-473. doi.org/10.100...
Kaul, I., Sawchak, S., Correll, C. U., Kakar, R., Breier, A., Zhu, H., Miller, A. C., Paul, S. M., & Brannan, S. K. (2024). Efficacy and safety of the muscarinic receptor agonist KarXT (xanomeline-trospium) in schizophrenia (EMERGENT-2) in the USA: results from a randomised, double-blind, placebo-controlled, flexible-dose phase 3 trial. Lancet (London, England), 403(10422), 160-170. doi.org/10.101...
Kaul, I., Sawchak, S., Walling, D. P., Tamminga, C. A., Breier, A., Zhu, H., Miller, A. C., Paul, S. M., & Brannan, S. K. (2024). Efficacy and Safety of Xanomeline-Trospium Chloride in Schizophrenia: A Randomized Clinical Trial. JAMA psychiatry, 81(8), 749-756. doi.org/10.100...
Paul, S. M., Yohn, S. E., Popiolek, M., Miller, A. C., & Felder, C. C. (2022). Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia. The American journal of psychiatry, 179(9), 611-627. doi.org/10.117...
Shekhar, A., Potter, W. Z., Lightfoot, J., Lienemann, J., Dubé, S., Mallinckrodt, C., Bymaster, F. P., McKinzie, D. L., & Felder, C. C. (2008). Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. The American journal of psychiatry, 165(8), 1033-1039. doi.org/10.117...
Yohn, S. E., Weiden, P. J., Felder, C. C., & Stahl, S. M. (2022). Muscarinic acetylcholine receptors for psychotic disorders: bench-side to clinic. Trends in pharmacological sciences, 43(12), 1098-1112. doi.org/10.101...
CLINICAL TRIAL INFO (In case you want to dive a little deeper or keep up with the ongoing trials):
EMERGENT-1: clinicaltrials...
EMERGENT-2: clinicaltrials...
EMERGENT-3: clinicaltrials...
EMERGENT-4: clinicaltrials...
EMERGENT-5: clinicaltrials...
ARISE: clinicaltrials...
Phew, that’s a lot, happy reading!
ALL MY LINKS: linktr.ee/schi...
Why I'm Doing This: • Why I'm Doing This | T...
SCHIZOKITZO PROJECT LINKS (AKA WHERE TO FOLLOW ME AND SAY HI):
Instagram: / schizokitzo
Facebook: / schizokitzo
Twitter/X: x.com/schizokitzo
MY OTHER PROJECTS:
My Bee Aesthetic Facebook Page: / beespokegirl
My Bee Aesthetic Instagram: / beespoke_girl
Disclaimer: I am not a qualified mental health professional. This channel exists for educational purposes, and I do my best to provide accurate and up-to-date information. In order to create content, I combine scientific resources (peer reviewed studies and easy-to-understand articles) and my own personal experiences/advice. I seek to make complicated topics easy to understand, but I am no substitute for a doctor, therapist, or other qualified mental health professional.
#schizophrenia #antipsychotics #psychiatricmedications #karxt #cobenfy #schizoaffective #schizoaffectivedisorder #mentalhealthawareness
I watched KarXTs development and have taken it 3 and a half weeks. It is weird, a panacea for SZ symptoms but it makes me salivate copious amounts a couple hours after taking it. Worth it!
Kit, you have a way of making complex material understandable. I'm a microbiologist, and the big words still scare me. Thank God there will not be a quiz on the material. Keep up the good work. ❤😊❤🐝🐝🐝
No quizzes here just information presented simply. I want to make the info accessible to as many people as possible!
@@SchizoKitzoI have a picture of a ghost on a tv.
@@SchizoKitzo I've been taking Alpha GPC to increase Choline on and off for a year or so and I've been getting really good
Eating 3 eggs 🥚 a day and 500mg of Alpha GPC
@@SchizoKitzo Kit, do you think this medication can treat the combination of bipolar and adhd? I have severe cognitive deficits/brainfog, but also bipolar 2, and I feel the Olanzapin I take now is counter-affective to my Ritalin. I really need Olanzapin to prevent mixed episodes, every time I've stopped it I've gone into one, so I need an antipsychotic/antimanic medication. But the Olanzapin decreases my dopamine, and the Ritalin increases it. It doesn't make sense.
But if KarXT actually increases the dopamine in the right places and lowers it in other places, it might be exactly what I need?? But since we don't know if it's treating mood symptoms (I've never been in real psychosis) I'm not willing to try it right now. But might this be an area where it can be a game-changer? When you have both cognitive symptoms from adhd and bipolar/schizophrenia?
what's ALPHA GPC?@@macrogenii
This is the best news I have heard.
The two people in my life with schizophrenia suffer from the negative effects. Seriously hoping it passes the trails.
I'm sure this new drug if it works well could destroy the practices of many naturopaths who rely on disordered people to purchase their "placebo-like" remedies.
It’s already been approved. There is a lag with original drugs and market availability after FDA approval.
Thank you for your explaning this. My cognitive and negative symptoms are the worst part of my schizophrenia so i know id be first in line to try this. Its interesting how different symptoms can be for people
I’m so relieved to hear there is at least A pharmaceutical option without extrapyamidal symptoms. Thank you science! May they continue to make further advancements in this area!
Thank you so much for making this video about Cobenfy and how it works! You explained it really well and I learned a lot!
Thanks so much for telling me this! It was so much fun to make. Take care!
Hi Steven! @survivingschizophrenia
Please know that many have dropped out of the karxt studies due to side effects. If you are considering this, maybe wait a couple months to see how and what people say about it after taking it. Also i know that clozapine is a really effective med and for one of karxt studies you could not be taking clozapine in the 8 weeks prior. So have your dr inquire into that before any considerations.
This sounds promising, honestly. I quit antipsychotics because the dopamine issues made me terribly depressed, and the cognitive issues made me unable to do art (thus making me even more depressed). I most likely will need meds again in the near future, so Cobenfy might actually be an option I'm willing to try :)
Cobenfy works! If you have nausea or rapid heart rate at the 100/20 dose get separate prescrip of trospium chloride (T part of KarXT, now called Cobenfy) , anyhow take 10mg of trospium 2 hours/20 min before Cobenfy and take trospium on an on empty-ish stomach. Cobenfy takes 8 weeks to be effective and then after that taper down slowly off prior antipsychotic , take months to do taper off prior meds.
Really great video! Your energy is amazing and clearly you are a very educated person who is passionate about your health as well as others. Thank you for being so forthcoming with this information. As a parent of an adult child with schizo-affective, who is non compliant with medication, it can be exhausting trying to find “the solution” to help. The correct prescription is an art that has not been mastered yet in his case. Hoping this new approach to this debilitating disease is a positive one.
Kit, this is a fantastic analysis of psychiatric news. Those earrings are also super-cute. Have a great week!!! I'm so glad you're directing your care and your life.
When I saw this video pop up I got so excited!!😂 you’re the only TH-camr I know who posts stuff like this. I freaking love neuroscience and hearing that there is an innovation in treating schizophrenia is something I’ve been praying for for a very, very long time even waaayyy before I started having my own psychiatric issues but obviously because of that now I’m more passionate about it than ever. The current antipsychotics are life saving medications…. But they also have the scariest side effect profile of all psychiatric medications. And psychosis is can be terrifying for the person experiencing it, they shouldn’t have to deal with the extra fear of the side effects of their medications. It’s about time there’s finally medication that is not only safer but more effective. I also hope that this might be able to help the people who are treatment resistant as well❤ this is very, very exciting. Any amount of research dedicated to this is exciting and it also makes it feel like there are scientists out there who CARE and that’s really comforting ❤
This comment is awesome, thanks!
@@SchizoKitzo 🥹🩷
I just made a video on Acetylcholine a few weeks ago and I just sent a link to psychotic in seattle about Cobenfy a few weeks ago. Thank you for doing a video on it! It's truly exciting to be getting a new medicine for the treatment of schizophrenia and schizoaffective disorder....its been a while since anything new has really come out. and it could definitely be a game changer...you rock! and great video
Awesome information. I've read several papers on it and like you I am doing well on my current regimen of antipsychotic/mood stabilizers, therefore as having schizoaffective disorder mixed type I would not be open to try it. But my hope is that it works well for schizophrenia patients. Time will tell.
These are good news! Thank you for sharing and summing-up all the information!
Edit: Also, congratulations on 30k subscribers! This hive is growing fast! 🐝
M1 (antagonism) is also *heavily* associated with dementia/senility and just the general aging of the brain. The number of crossovers between dementia and delirium is quite conspicuous. M1 antagonism has even shown to result in the classic aimless wandering and other dementing symptoms of diseases like Alzheimer’s.
Okay I literally just found out that you're earrings are pill bottles lmao love them ❤❤
Wonderful description, this is some good non biased research!
I just want you to know that this video has given me a little bit of hope where practically nobody, professional or otherwise, has really done so much in recent times. Thank you for making such well communicated, concise, and most importantly, accurate and true to the real lived experience of schizoaffective disorder, as well as the scientific research as it slowly stacks up, balances out, and filters it's way into clinical settings. Congrats on the 30K!!! You deserve so much success and I really pray that the universe karmically compensates you tenfold for all the good you are doing for so many people out in the world, including me. Stay safe, stay well, and stay smiling. Lorelei🌸
Thank you so much this is so kind! Im glad I’m able to help ^_^
This medication sounds really promising and thank you for explaining all of this information in such a clear and thorough way. Also, those earrings are sick!
Glad it was helpful and thanks!
I hope that all the future experiments show positive results. Something new would be very helpful, since all we are doing now is dealing with the same receptors. 🙏
I am watching this at 1 am so I may have missed some points. I thought some of the things you said made it sound like this drug might also be very promising for Alzheimer’s. If so that also would be amazing. My Mom took medicine for Alzheimer’s and I saw no improvement or help from those meds. Oh, if she fell asleep after taking it, she had terrible nightmares. That is a result but not a good one, so nothing good for her. I think your plan to continue your current meds for all the reasons you stated is an excellent one. Brings to mind two sayings: 1.) If it ain’t broke, don’t fix it; 2.) The enemy of good is better. Thank you for you very thoughtful informative videos! I look forward to them!
It definitely seems to have promise for Alzheimer’s, but only time will tell when it comes to the science. That was where xanomeline got its start after all!
I wasn't quite ready for a super informative MH summary from a gorgeous fantasy today 🫠
Many thanks Kitzo 😂❤
Thanks Kit! This wasn't on my radar before. I'm gonna need to look into it more.
Happy to see your channel taking off more. I was here before the first 1K
I'm glad you kept up with the channel and didn't get discouraged by how slow you were getting subscribers the first few months.
I've seen so many great channels over the years with huge potential give up because of how slow subscriber growth was the first year. So its great to see you kept grinding with it, and kept getting better.
Stay strong and keep it up.
👍
Awww thank you so much for this and your kind words! I’m nothing if not tenacious. Thanks again!
Edit: hyped you were here before 1k. Those were wild times.
I think that every person is an individual and need a medicine to match specific symptoms. So the more alternatives there are to choose from, the higher the probability to find something that works well for you. It is time for doctors to learn there is not a ”one size fits all” when it comes to medication, not one thing that is the best for everyone. Being a doctor should be an art and not an industrial process. The pharmaceutical companies want to sell as much as possible so they want to say that it helps as many as it can. You have to be an active patient and learn as much as you can about what you need. Just as you are doing in this case! 😊
The yearly cost of cobenfy will be around USD 22'000!
@ That is just crazy! But Olanzapine was also very expensive when introduced. It is a big diff between the US and Europe, here a year of Olanzapine is about $250 right now for a low dose, maybe a $1000 for a max dose.
I'm using the keto diet medical intervention for my schizophrenia. It's a natural way of eating natural foods. No carbohydrates or sugars. Your brain runs on fat instead of sugar. In 6 months I haven't been psychotic, unheard of for me if you take into account the stress I've been under with work and social life etc (,the more you can handle the more you get) this stress would of had me psychotic before keto 100% I may have to "alter" the way I eat eg more fat from nuts etc in order for my health markers to be great when my blood test comes through, but I will work around that. It might be great as is. If my markers are good, I am going to ask to lower my meds. Lauren from her previously named channel "living well with schizophrenia" is using medical keto and she is off all meds, and symptom free. I just want to half one of my 3 daily anti psychotics at the moment. Quite funny, Lauren, the biggest schizophrenia based channel is using keto and reducing meds, and me with the smallest schizophrenia based channel is doing the same 😅 well, "small" channel? I'm saying " indie" ha
I am also using a medical keto diet and have been thriving. My mood has been stable for 6 months. My doctor is schocked. I have stayed on medication but prior to the ketogenic diet my mood was still unstable. I really wish Kat would try a medical keto diet. She would benefit greatly.
Glad to hear it worked out for you. Keto does seem to increase GABAergic activity (calming signals) in the brain among other things. I went on it for weight loss and did not realize it would also make me nearly forget that I had binge eating disorder and ADHD. It's a great tool for many medically.
@@lifewithbipolardisorder1 are you in the US? do you have a keto med dr/advisor? And a psychiatrist who’s willing to reduce meds?
@@writerwebisland are you in US? Please keep posting about this, ty
Did you work with nutritionist or metabolism psych?
Thank you so much for sharing this information so thoroughly. This medication may indeed change my life as I suffer from debilitating negative and cognitive symptoms.
Healthcare advancements like the development of new meds are always really exciting to me, so this video was awesome! Thank you for such a great breakdown of KarXT and how it might help treat negative and maybe even cognitive symptoms in addition to positive symptoms. As always with your videos, I learned so much from this one. And I look forward to finding out how things pan out with the use of KarXT over time.
(BTW your earrings are fabulous! Not to mention perfect for a video about a new medication, lol)
Thank you for the thorough detailed explanation, it's interesting stuff and I hope it helps many people
This is so interesting! (I wonder why they didn't combine with Xanemoline an anti-cholinergic, such as an antihistamine, to counteract the cholinergic side effects. Maybe tolerance formed, there was excessive sleepiness, and also ongoing use of anti-cholinergics is not ideal for long term cognition)
Hello! The trospium chloride in KarXT actually is an anticholinergic to offset the side-effects, but it’s an anticholinergic that doesn’t cross the blood-brain barrier (so it’s similar to, say, buscopan, rather than an anticholinergic antihistamine like Benadryl). As such, the trospium chloride element should be safe for cognition in the long-term, and since xanomeline increases cerebral muscarinic acetylcholine, it’s got the opposite mechanism of action to the stuff that’s bad for cognition. (Memory involves acetylcholine receptors, hence why suppressing them long-term isn’t the greatest plan. If I’m correct, this is why xanomeline was originally trialled for alzheimer’s!) So hopefully, this should be ok!
Trospium is anticholinergic thats exactly what its there for
Who else cried a little when she said that the m4 receptor was related to dopamine release? 😢
Only junkies did
They were happy tears from me!
Brilliant Kit thank you so much for talking about the science and the negative and cognitive symptoms that plague us. So good well done❤
Thanks! I am a fellow afflicted person, and I am curious, however I too have mood symptoms, and am stable, so probably not going to take it.
Btw you're very pretty! 🌹
Aww thanks so much for this! I appreciate you!
Kit, thank you for your really informative video. You explain the complex in a very realistic way so that we can all understand. I have Bipolar 1 and have been sectioned/hospitalised several times. I take Lithium and Quetipine (I tapered off Diazpam and Pregablin earlier this year). Lithium and Quetipine work well in my case and I have been stable for about 2 1/2 years now. I had so many changes to my medication and I hate and refuse antidepressants - as they made my symptoms worse! - I was commenced on I think nine antidepressants, some I had to discontinue as they were starting to induce mania! I would not wish to stop Quetipine as it works. True there is what I call "background of Bipolar", however it's so well controlled now, I am able to live a normal life like every one else. I shall make a note of this "Car XT", just in case my meds stop working. Thanks for the information. Good health to you. God Bless. Pauline
Omg i am bipolar too but please don’t take quetiapine. I took it for 3 years and it made me lobotomy.. I take sertraline and lamotryginę and since I’m taking the 2nd one it works soooo much better for me and I’m glad my doctor gave me it. Ability was great too but I had terrible akathisia. Wish it didn’t made me have it. Also quetiapine made me have dyskinesia. Still.. have it. Not that much but I do. Shocking.
@brak1827 Hiya! Thanks for that. Mines type 1 and I can't tolerate antidepressants unfortunately. Earlier in the year I finally came off valium and Pregablin. Ended up on three different antihistamines and an extra antipsychotic to manage physical withdrawals. I am still symptomatic and have an ECG on Tuesday. Hope the Pregablin has not done lasting damage! I know what you mean. We have to trust professionals "for our own good", and I am sure they do their best with a good conscience. There's a problem when clinical studies are not being done properly in the first place, so not even Doctors have insight into long term effects of "safe" medications! More work needs to be done into the long term safety of these meds. All we can do is tell our Doctors when something does not feel right with our meds. I hope your symptoms go away soon.
Since it doesn't touch dopamine and serotonin, can it give me back my emotions and creativity?
Yes
Your video popped up in my recommended. Just here to say your earrings (and entire look) are delightful. You're like funky punky snow white and I love it.
I think it's worth pointing out that muscarinic agonists decrease dopamine levels and can induce depression and anhedonia similar to dopamine antagonists because of this. I still think xanomeline being approved as a treatment for schizophrenia is really cool though
This is revolutionary!
i was WAITING for this like there’s genuinely not good vids on this drug out😭❤️
I don't know why this popped up on my feed, but glad to learn more. Thanks 👍
Thanks for watching!
Thank you so much for explaining the science behind it. I love learning about medications and brain processes on the molecular level because i don't like half a story or the idea that the brain is a mysterious black hole.
I specialize in deep dives that people can actually understand. Thank you for this comment!
Thank you for this
Love this educational video. Let's hope this new medication will work wonders in the long term.
I hope so too!
Sometimes I am thinking that I could be a scizophrenic too but all the nine different voices in my head are telling me that I am normal and healthy, so Im feeling relieved now.
Kit that was really interesting…also I love your earrings!
Love the earrings!
I have schizoaffective disorder and my Mom works for Bristol Myers-Squib. She's been telling me about this. I'm pretty stable on Clozaril, but I'm thankful there might be an alternative.
Every pharmaceutical drug is a "game-changer" until 20 years have passed, and they become the subject of an indepth case study.
This! Actually it's more about drugs in general. If you look at every drug introduced in modern society. They first get hyped then disliked and even demonized by some.
KarXT is over 20 years old - it was originally developed in the 90s for a different purpose. No in-depth case study here.
@DorianBrightMusic Then, how is it a game changer? Isn't that term usually reserved for something new that's going to change the game? Seems like an odd thing to say about something that's been around for that long. I mean, you can't have it both ways. I took Depakote for seizures, and it had an identical backstory. It was actually developed for behavioral issues, then it was transitioned into an anti-seizure medication. That still didn't cover up the fact that it's extremely destructive to people's livers. Side effects don't differ depending on the intended use, I'm afraid. The case study won't begin until the class action lawsuits begin. Give it some time.
@DanielAnderssson Absolutely. In about 3 years of being on Depakote, they probably checked my liver bloodwork a dozen times. I only had reading epilepsy, so I stopped taking it, and eventually, the seizures cleared up on their own. That was 25 years ago. I'm confident that I'd have full-blown cirrhosis if I hadn't quit.
@@dave23024 Game-changing from the perspective of 'not being a dopamine antagonist or partial agonist'. This sounds nitpicky, in that 'so what? It's still an antipsychotic', but it says two things: 1. it's proving that we can develop antipsychotics that don't directly target dopamine; 2. we can develop antipsychotics that are better for the cognitive/negative symptoms; 3. that we can, hopefully, move beyond the era of accepting some of the worse side-effects of antipsychotics.
Pharmacologically, it's game-changing because it represents the possibility of an entirely new class of antipsychotics, meaning that drug development (which has stalled, though not stopped, since the early 2000s) can hopefully pick up pace again.
But more importantly, it's hopefully game-changing in terms of 'we don't have to tell people they're going to have to choose between different neuroleptics'. Game-changing in that it's not a major tranquiliser. I jumped for joy when I saw the news that KarXT had been developed, since my first thought was that with luck, this will be the beginning of an age of better patient-centred care. Now that we know we have more options than drugs based on something originally intended to be an anaesthetic/sedative, we can give people more choice in what they take. And I'm incredibly excited for this, since people with psychosis have had to deal with the very reasonable fear (and sometimes reality) of mistreatment by professionals. If we know we don't have to put people immediately on neuroleptics that are more tolerable than what we had in the 1950s, but still not fantastic, then I'm really hopeful for what this could mean for quality of life.
While it's been around a long time, it's only been investigated for psychosis recently, and only approved this year (in the US - here in Australia, it's not even a known quantity). It's been pretty rigorously tested, and it's been considered really carefully - hence the long time before approval. So, no, it's not odd that its development could've begun so long ago, but it could still be a game-changer, in the same way that the reintroduction of clozapine was a game-changer despite its initial appearance in the 1970s.
Also, KarXT promising in that it's looking at NMDA receptors, which have largely been neglected in psychosis pharmaceutical research, never mind that we know how important they are in psychosis. As such, it's game-changing in that it's the first medication to even approach an oft-overlooked but crucial aspect of schizophrenia spectrum disorders. It's also effectively a message that we do not need to keep trying to get more mileage out of the dopamine hypothesis, which has been central to most psychosis psychiatry so far. While the dopamine hypothesis is partially true, it's not the full story; KarXT not only acknowledges that, but makes changes based on that.
I'm really sorry to hear about your experience on depakote. By all means, that should not have happened, and I really hope that your liver is alright now. You ought have been better informed. I absolutely agree that we need to be very careful about how meds are approved, and about how they are developed. And I agree that scrutiny of the industry is important. However, practices have improved since depakote was developed. While awful experiences will continue to happen, new drug development will slowly lead us closer to being able to minimise side-effect burden or best prepare people for it. While KarXT doesn't lack side-effects, it's lacking many of the most awful ones of most other antipsychotics. It's absolutely true that it won't be for everyone - for some people, it won't work, or the GI side effects that it already has will be intolerable. However, that's true of all medicine - we need a choice of drugs, since some people can tolerate certain side-effects better than others.
It's absolutely important to be sceptical - for example, we didn't know about the correlation between, say, long-term amitriptyline usage and dementia risk until recently. As an amitriptyline user who's probably in it for the long haul, I find that terrifying. But with my symptoms, I have very little choice. Frankly, that's infuriating - and this is why more drug development is important: finding safe alternatives bit by bit. Back when amitriptyline was approved, knowledge about neurotransmitters and neuroscience was far less advanced, and guidelines for development were far less stringent. I don't want to make false promises that nothing will go wrong, but I do suspect that in this day and age, we're far less likely to see as enormous an oversight in the literature. Antipsychotics, prescribed wisely, can hugely improve quality of life for psychiatric patients. Their evolution also links to some game-changing developments in allergy treatment. So I would say that on a macro scale, the risks/benefits ratio of KarXT's approval is absolutely in favour of the benefits for both pharmaceutical development and patient-centred care. In that regard, while we can't say anything just yet, it's very, very likely it will be game-changing.
(My apologies for the extremely long comment. I'm really passionate about psychiatry, so I got a bit carried away. However, I hope that the information here is useful. Thanks for taking the time to read this.)
Well done!
I’m amazed at how the researchers were able to knock out specific m receptors and then measure dopamine changes in rats.
The tech is … yeah amazing.
Hope the new med works.
They’re called “knockout mice” which to me sounds metal as heck. They can do all sorts of things with them!
Terrible 😭
You give a beautiful and clear explanation of schizophrenia!!
Only halfway through the video, but this is awesome.
I wonder if it will be used on schizoaffective disorder. It runs in my family.
Assume you can supplement with other stabilizers.
The drug doesn't appear approved for schizoaffective yet.
Edit:
You literally covered this. Maybe I should have waited XD
No worries, glad you liked the vid!
thank you kit!❤
Thanks for the video. I'll bring up KarXT to my psychiatrist. I feel like I'm doing pretty good on the generic of Abilify. There's a lot to process from this information.
Great video, Kit! I have schizoaffective disorder. I experience everything. My depression is better these days but I struggle with negative symptoms and cognitive problems. Maybe this med would help me. Thanks for explaining all of this.
Really interesting! As with many medications, we don't know too much about long term effects, but hopefully it remains safe and effective.
Wow, that was a scientific account! The real scientific progress happens slowly, step by step. Now when a new medicine is at focus, all peaces of the puzzle already placed!
It’s so slow but science has done so much good 💪
Love this! We need more hope for treatments, would you be able to do anymore videos on the future of treatments for schizoaffective and where you predict it will go? E.g DBS surgery?
Thank you so much. 💙🙏💙
Thank you so much for this, and all of your content. I’m so grateful for your wisdom as I help my 21 year old daughter navigate psychosis. Doctor mentioned this new medication- could help with severe anhedonia?
Your content gives me hope❤
OMG this is so interesting! I learned a lot! Thank You!❤
This is so exciting👏
IM SO EXCITED
This was so refreshing! I'm using Xeplion and it makes me so anxious and depressed 😔 I hope this new medication can prevent psychosis and at the same time not give me such side effects like angst, depression and lack of motivation and concentration 😅😊 when will it be available in Scandinavia i wonder 🤔
Wonderful video, thank you. Super interesting
Cool! Great info, thank you!!
Do they have any idea about how this new drug combo will potentially damage kidneys? I seem to recall that being a worry about your current meds with long-term use, so I wonder if this new one is less damaging in that way.
The negative symptoms are the hardest to treat. I wish I could afford KarXT. This seems like a good drug.
Side question: do you think it’s possible to combine any ADHD medication (whether @mph*tam*ne, m*th*lph*nid@te, atomoxetine or guanfacine/clonidine) with a pre-xanomeline antipsychotic to also treat the negative symptoms? I feel like I’ve heard of this combo used in bipolar disorder but I could be wrong.
The problem with antipsychotic research is that we keep looking for "silver bullet." If it's not dopamine, it must be muscarinic. Oh no, it's definitely GABA, or probably just immune system. Let's go with immune modifier.
Not saying those are wrong approach, but for now, it still looks like different competing groups with different theories.
I hope we can truly understand what is wrong in brain with schizophrenia in around 50-100 years.
omg happy people who choose medication have options with less side effects, i was on geodon in my 20s and gosh it was so tricky for my brain 👋
Wow, this sounds really promising. I’m praying that it’s an effective new treatment for schizophrenic spectrum disorders, and selfishly, that it will also be helpful with negative features of bipolar and mood disorders 😊
Wow, thats amazing! An give me so much hope
Always happy to see the bee
She’s always happy to bee in videos! 🐝
amazing insight!
I'm a schizoaffective patient and i'm 100% asking my prescriber about this
My son is in psychosis and was waiting for this but psychiatrist are not placing him on that.he is on clozapine. But resistant.
clozapine doesn't work for me no longer I'm hoping this will work. this gives me hope.
love the Rx earrings Kit, thanks for the educational videos
This is promising! I also have schizoaffective so Idk if it would work for me but I would maybe try it if it becomes available.
think you❤
Its key to take this medication on a completely empty stomach not even coffee or liquids. In order to not get the nausea. Give it 2 hours then you can eat again.
I hope this works also for ocd.
Great video! 😁
interesting info kit.
Cognitive issues? This is a big one. At least I think it is as it is a large part of things that have and continue to be a huge problem. It is possibly one of the largest parts of it all that has taken the most from me in life. I have not been able to work in ages, my personal life is all but gone with me being alone all but maybe a few hours on a good week with most of the interactions I generally have being with the various people working at the local shops I go to buy things like food and general household goods. My ability to recall things is very screwed up. I have a hard time putting what I do have for memories in the correct order. That and having large portions of time totally missing causes me wildly high amounts of stress, frustration and confusion that has likely caused those who were in my life to distance themselves or even totally leave me out of things thus causing me to face all of this almost totally on my own. With such a hard time remembering things and missing entire chucks (not hours but days, weeks and even months depending how bad things got) it is hard to try to function alone as I question everything. I may think I did something, but didn't or think I didn't do something and I actually did. Then there is simply not knowing at all and seeing possible signs of me doing various things without any idea of if it really was me and if so when, it's just blank.
This gives me hope that there is continued work to try to figure this out and find some way to at least try to treat this. Maybe I will not see anything in my life as I am getting up in years (over 50) but I can hope it can help someone in the near future so that they do not have to face the living hell I have.
Have you explored medical keto in adition to medication?
Nope and I won’t
Anti Psychotics are All Kaput. Decades ago. Still listening. Thanks!
Kit is a very very smart gal 💕
i live in south east asia bangladesh can i get that medcine i suffer a lot in my life with my memory
Love the earrings
do u think that it has some kind of potential vs catatonia. some antipsychotics help, but mostly they do not.
I just need to know where to find those earrings🔥🔥
i wanna ask my doctor if I can try cobenfy with my current lithium for schizoaffective.
Sounds very good, I would take Karxt cause I have undifferiated schizophrenia, but probably I'll have to wait until 2026 cause I live in Europe, here the trials are still going.
Can you please tell the medication that you are currently on.
I have many videos about what medications I take :)
I’m asking my psychiatrist for this. I’m highly sensitive to meds, so I’ll let you know if I can get it 😊
Ive been so sick of simply being tranquilised!!!
I love Kart Coben
I love your earrings!
Girl those earrings really ask/tell a story!
Wow! KarXT sounds promising. I schizoaffective disorder with major depression and experience both positive and negative symptoms. After hearing what you described about the medication, I would love to try it, pending it comes through the long term testing favorably. My current medication at the dosage I take it at causes so much daytime somnolence and of course it doesn’t treat the negative symptoms. So I’m hopeful for this medication. It will just be part of my daily ‘cocktail’!
the article below is suggesting using non-invasive neuromodulation through transcranial magnetic stimulation.
Nice
It's sad that YT won't let me post a link here, even though it's scientific subject.