VANCOMYCIN Mechanism of Action

VANCOMYCIN Mechanism of Action
Vancomycin is an antibiotic drug which is structurally classified as a glycopeptide. It mainly acts by prevention of cell-wall biosynthesis of bacteria. It is specially effective against gram-positive bacteria and has been known to be effective against resistant strains of MRSA. Vancomycin is known as the drug of last resort as it generally used when all other treatments have failed. However, bacteria have started developing resistance to vancomycin as well- leading to use of other antibiotics.
Vancomycin acts by inhibiting cell wall synthesis of bacteria. Peptidoglycan layer of the cell wall is rigid due to its highly cross-linked structure. During the synthesis of the peptidoglycan layer of bacteria, new building blocks of peptidoglycan get inserted (i.e. monomers of N-acetylmuramic acid and N-acetylglucosamine) into the membrane.Vancomycin inhibit the synthesis of bacterial cell wall phospholipids as well as peptidoglycan polymerization in a time dependent fashion by binding to the D-ala-D-ala side chain of the precursor pentapeptide.This prevent the transglycosylation step in peptidoglycan polymerization . By doing so, vancomycin makes the peptidoglycan layer less rigid and more permeable. This causes cellular contents of the bacteria to leak out and eventually death of the bacteria. Mutations in the transpeptidase enzyme can lead to increased resistance to vancomycin.

[@rickykalendarov1176]

wow. this was the most amazing video explanation i have seen in a really long time - you are a talent. thank you!!!

[@brycebrunetti9145]

Amazing presentation and explanation of the mechanism. It help me firmly grasp how vancomycin works. Thank you!!

[@Medinaz]

welcome

[@acingmedicine]

simple and to the point, thank you

[@Medinaz]

You're welcome!

[@khalidkhan6405]

EXCELLENT.. GOOD WAY TO MAKE EASILY UNDERSTAND

[@stopit9280]

Thanks for the info.

[@misse2359]

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[@saiurysarmento1560]

I loved this video and your explanation about of the mechanism. Thank uu

[@moism]

Thank you

[@deepaj8727]

Your videos are so helpful please do more videos

[@mangalthorat7951]

Very nice video, thanks a lot.

[@mimkhatun5165]

Really amazing presentation. Subeffective and excellent explanation. 💗💗

[@saloni2496]

Love your channel

[@StudyWithM3E46]

Thanks alot. very basic explanation which is exactly what I needed to understand for my exam

[@khaledasmedlife]

abey oo meethey gudd tapak rha hai

[@ayesha4670]

So helpful.thank u sir. Plz one lecture on antihypertensive drugs.

[@bhabanishankarkarmakar3294]

Thank you 😍

[@Medinaz]

Welcome

[@hhaider5group]

Good 👍

[@sakeelahmed6118]

Great.....bro......

[@Medinaz]

thanks a lot

[@SurajKumar-ly7ws]

Thanks bro

[@Medinaz]

:)

[@longassride8054]

Awesome explanation

[@Medinaz]

Glad you liked it

[@surojitbera1501]

nice explanation

[@Medinaz]

thank you..🙂

[@user-fb9vh2sm5q]

Can you wite down the explaination

[@minghei2010]

what is osmotic burst?

[@Themedicosis]

Mechanism action of noscapine

[@p_r_creation6046]

Hello sir sir can you please upload moa of b lactum antibiotics!

[@frankal1090]

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[@thereal7490]

wooooow
really creative

[@Medinaz]

thank you so much

[@user-fb9vh2sm5q]

@@Medinaz
Hello..I am facing a difficulty with the accent
Can you write the explaination?

[@aiezmunir9608]

Nice

[@Medinaz]

Thank you

[@chandamitagoswami7745]

I think the cross linking is done by transpeptidase

[@itsSirJee]

Yes..but vancomycin inhibit only elongation of chain by inhibiting D-alanyl-D-alanine

[@eagleclaw1179]

Mechanism of fidaxomicin and metronidazole

[@user-ks5es7sq9w]

Good

[@Medinaz]

thank you

[@zelenplav1701]

My son got heart disease fom this necause of MRSA. He has 10% heart function. His Md wanted $50 for each visit, which we could not afford. Now....
...

[@aadufie]

lovely presentation. dont think i will ever forget. Thank you so much

[@kenken42]

types of hernia video...

[@Medinaz]

I will try..🙂

[@minghei2010]

doc是什麼? what is doc?

[@filuthamanna3818]

Drug of choice

[@surojitbera1501]

i think the same mechanim of action is for penicillin

[@Medinaz]

Not exactly the same...Penicillin interact with the Transpeptidase enzyme and inhibit the Transpeptidation reaction which is necessary for cross linking of nearby peptides..and the consequences will be the same..

[@itsSirJee]

No

[@ayushimishra2571]

😁

[@Medinaz]

:)

[@tahirismail4279]

Wrong mechanism of action