Base excision repair

[@haileyyoung7558]

you've made a seemingly complicated process very easy to understand, thank you!

[@FMshorts17]

It's wonderful bro....now I,m feeling that it,s so easy to understand it

[@blueballoon7832]

the animation shows a 3' to 5' DNA pol. but the narration say it was a 5' to 3' DNA pol, so which one is it?

[@allaboutakoo]

dna is always built 5 - 3 prime

[@cygthings]

The overall direction is 5' to 3' but in that instance, the exposed ends are 3'-OH on the left side and 5'-P on the right side.

[@Phoenix-np1iu]

if i understand correctly, each nucleotide has a 5 prime end and a 3 prime end. the new nucleotide is added so that its 5 prime connects to the 3 prime of the one before it

[@mohamedelafia4956]

i think N Glycolase does not remove the base it just identifies the wrong base. ap endonuclease cleaves the region and the base will be removed from 5 exonuclease than comes polyemrase one with the base and finally dna ligase to repair the cleavage.

[@royalindication]

That's exactly what happens if I'm not mistaken

[@sameerhussain3709]

no he is correct you guys are wrong..... read books 📚📚📚

[@becheaachi]

You think wrong man...glycosylase breaks the n-glycoside bond between the base and sugar

[@wolfbaron25]

What does AP Lyase do in this context?

[@cameroonian7]

Now that I see it, I understand. Thank you !!

[@Hansepi_hansepi]

Thank you🥰

[@quratulain3252]

super helpful thank you

[@arzuhaqverdiyeva4237]

Thanks . L am Azerbaijan💪🇦🇿

[@husammatar5543]

Thank you so much you are really goog to explain.

[@shashios1236]

Very nice 🙏👍

[@63554]

Thank you

[@Hg80_Jxs]

saved my life

[@bhatti7714]

Excellent 👌

[@aditimane3349]

Amazing 🤩😍

[@Biochemist448]

best video ❤

[@sushamabhumbe6296]

It's helpful ☺️

[@deeptiaditya9133]

Thankyou sir

[@alanoodalhouqani7036]

thank you so much

[@anowartheplantbreeder..8660]

When DNA glycosylases remove modified base then already 3'OH nd 5'P site open so AP endoculease what actually did??🤔🤔

[@tanvirahmed-rr7vt]

Nope the phosohodiester bond is not broken as the nucleotide moeity( without the base) still remains at the region..

[@ibrahimbakhet6657]

I think it removes the suger

[@AliKhan-ns2dp]

Weldone

[@iam7405]

❤❤

[@judytoma8733]

Great

[@songohan393]

thank you

[@alimamstudying9462]

Thank you so much

[@rabiaghafoormalik2026]

Weldone