DNA Repair Mechanisms Part 1

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6:40 that bingo is soothing sehar ❤🥰
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[@zubairalamkhan]

You're following "Biochemistry" by Jeremy M. Berg, John L. Tymoczko, and Lubert Stryer.??

[@EasyPeasyLearning]

This is more of Lippincott and lehninger's

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Great explanation. Thank you

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Mam you have the best accent

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[@বাংলাওবাঙালিয়ানা]

Thank you so much for this amazing explanation .Ma'am, I have a question to ask you. What is the function of DNA helicase II in NER of Prokaryotes?

[@EasyPeasyLearning]

Hi there, apology for late reply, Various DNA helicases, a group of enzymes capable of separating DNA duplex into two strands through ATP binding and hydrolysis, are required by NER to unwind the DNA duplex around the lesion to create a repair bubble and for damage verification and removal.
The reference of this statement is www.sciencedirect.com/science/article/abs/pii/S1874604723000057#:~:text=Various%20DNA%20helicases%2C%20a%20group,for%20damage%20verification%20and%20removal.

[@neverlandxoxo7517]

Great explanation only one question.. doesnt mmr rely on dna pol 3 not 1?

[@Gokukevin-786]

Do these occur in prokaryotes? Or in eukaryotes only?

[@summersummers9233]

MutS, MutL, and MutH are present in prokaryotes. The eukryote counterparts are called MSH and MLH. MutH does not have a ounterpart in eukaryotes. The nick created due to Okazaki fragments is used instead.

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good summary, thanks :)

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great video thanks!

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Very well explained

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That's a perfect video Madam

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[@葉孟婷-e7u]

NER
Problem : Pyrimidine dimer
Mechanism:XPC detect the damage and recruit XPD and XPB to confirm the damage
Helicase unwind DNA
XPF and XPG remove DNA
DNA polymerase bound and made a new DNA.Ligase connect everything.

[@littlefinger8613]

When dna repair mechanism don’t function properly, is there any chance the damage cell become malignant cell?

[@EasyPeasyLearning]

Hi there, if the damage occurs on the Gene's that are going to code for cell division process or apoptosis which is a program cell death, then there is a chance that they will become malignant cells.

[@littlefinger8613]

@@EasyPeasyLearning thanks

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[@shabnammohare9677]

Every thing all right...but we need written notes for this

[@srilekhamanigandan246]

Yes 🤧

[@EasyPeasyLearning]

Hi there, The material was taken from the book of Lippincott's Biochemistry 5th edition.

[@HeshamMahrous--]

Okay,, :D

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