DNA Repair Mechanisms Part 1
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- เผยแพร่เมื่อ 4 ส.ค. 2024
- This Video Explains the DNA Repair Mechanisms That Are Mismatched Repair System (MMR), Base Excision Repair (BER) And Nucleotide Excision Repair (NER).
Link For The Second Part Of This Video:
• DNA Double Strand Brea...
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For me, it's the PACE OF YOUR VOICE that made the explanation more worthwhile.
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this series on genetics is super helpful!
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Very good explanation.much love from kenya
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Great explanation. Thank you
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good summary, thanks :)
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great video thanks!
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Helped a lot 🥰 Keep up the good work 👍
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You're following "Biochemistry" by Jeremy M. Berg, John L. Tymoczko, and Lubert Stryer.??
This is more of Lippincott and lehninger's
ok thanks
Thanks you so much Sehar ..
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Great explanation only one question.. doesnt mmr rely on dna pol 3 not 1?
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Very well explained
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Thank you so much for this amazing explanation .Ma'am, I have a question to ask you. What is the function of DNA helicase II in NER of Prokaryotes?
Hi there, apology for late reply, Various DNA helicases, a group of enzymes capable of separating DNA duplex into two strands through ATP binding and hydrolysis, are required by NER to unwind the DNA duplex around the lesion to create a repair bubble and for damage verification and removal.
The reference of this statement is www.sciencedirect.com/science/article/abs/pii/S1874604723000057#:~:text=Various%20DNA%20helicases%2C%20a%20group,for%20damage%20verification%20and%20removal.
That's a perfect video Madam
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Do these occur in prokaryotes? Or in eukaryotes only?
MutS, MutL, and MutH are present in prokaryotes. The eukryote counterparts are called MSH and MLH. MutH does not have a ounterpart in eukaryotes. The nick created due to Okazaki fragments is used instead.
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Okay,, :D
NER
Problem : Pyrimidine dimer
Mechanism:XPC detect the damage and recruit XPD and XPB to confirm the damage
Helicase unwind DNA
XPF and XPG remove DNA
DNA polymerase bound and made a new DNA.Ligase connect everything.
When dna repair mechanism don’t function properly, is there any chance the damage cell become malignant cell?
Hi there, if the damage occurs on the Gene's that are going to code for cell division process or apoptosis which is a program cell death, then there is a chance that they will become malignant cells.
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Every thing all right...but we need written notes for this
Yes 🤧
Hi there, The material was taken from the book of Lippincott's Biochemistry 5th edition.
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