Thank you! Wow, seeing this 10 years ago would have saved a career. Ten years of trial and error later with various doctors and supplements, and I still learned something here. What a blessing.
My daughter got a virus ib 7th grade and Covid last year. It set off pots and she hasn't been to school in 5 years. She had a procedure and I told the anesthesiologist that she needed steroids wuth her anesthesia. She did not do it. My daughter ended up in ER 15 times and hospitalized 4. She almost had to get a feeding tube. She just kept screaming "the confusion!" Broke my heart. She's on Allegra and Pepcid and going to start Xolair. We've been homebound 14 minths since procedure. She's never had a summer her whole teen years. 😢
I just heard of dr Dietrich Klinghardt and Connie Fox. Please research them. They may be able to help you. As always Prayers are first and foremost. I pray she gets well.
Breaks my heart to hear kids going through these things. I hope she was not vaxxinated by c0vid shot. There' s a great ND/Functional medicine doctor in California (San Diego) Dr. Pedi Mirdamadi from Oasis Health Medicine.
@@DoubleOhSilver B1 can cause anxiety and jittery feelings as well as intense sweating if your sensitive to it. Also when you use ANY synthetic vitamin (particularly B vitamins) they can build up in your system and cause neurological problems
@@DrA-OnlineI absolutely am at the histamine aldehyde stage 😭 I've been unable to treat for 5 years because I can't tolerate most supplements. I'm beyond terrified (which then makes my mcas and histamine worse being in such a high stress state). Can I just start with b1 or do I need to add the other things further up the chain first? I'm getting sicker and sicker neurologically so have to do something.
You're my MCAS Angel, Dr Paul. Fifty-four years of trying to get help and legitimacy has been a rollercoaster of hope and despair. It all started with a severe case of Mononucleosis at age six. Wish more Doctors would listen to these TH-cam videos for a lil education. Thank you for making my life better with your concise information that has done more for me in the last year than anyone else has ever done. Blessings upon you.
@@nford3886 Thanks for replying. Could you share by any chance what has worked the most for you? Also, have you had problems with severe anxiety throughout your life? Some info from my end: know that “MCAS” is a presentation with an imbalanced T-helper 2 (“Th2) cell response compared to Th1, and that fairly recently T regulatory cells have been discovered, which produce cytokines which act like a negative feedback to the inflammatory Th1 and Th2 response, and these Treg cells get upregulated by proper vitamin D availability. Studies on hunter-gatherers show consistently that they have about 45ng/ml of 25-hydroxy vitamin D in their blood, and these people don’t seem to have allergies or immune dysfunction. This high serum vitamin D level by being outside might be a key to this, alongside many different other factors, but vitamin D is notoriously low in Western populations. Thus, sunbathing or supplementation of vitamin D3 (+K2 MK-4) and magnesium for activation of D3 might drastically help with stabilizing these overzealous mast cells. Fat soluble vitamins are synergistic so you might want to look into vitamin A as well, given that this is also a very immune-related vitamin and some people (those with BCMO1 gene polymorphisms) might need specific animal sources such as liver or cod liver oil to get enough of it, because they have difficulty getting it from plant pigment (beta-carotene). Another thing to know is that chronic stress due to anxiety disorders, trauma, unhealthy social or work situations, etc. cause chronic corticotropin releasing hormone secretion, which drastically activate mast cells. It is therefore no surprize that people with chronic (idiopathic) urticaria often see this condition appear after periods of chronic psychological stress, and see them disappear when their psychological state is normalized. Also, this is a positive feedback loop, as MCAS can cause anxiety via many different direct and indirect ways. Vicious cycle. Good luck. Hope it’s helpful.
I found this fascinating! My husband and daughter just had a ton of testing and go for their follow up with a MCAS specialist next month. But the methylation issue rings very true for my husband. Methyl folate causes him to spiral into depression very fast and hard. It’s SCARY! Definitely a toxic reaction in the brain. I will try thiamine to see if we can unplug that pathway. Thank you so much for this series! It’s very, very helpful!
Please update us!! Need to know how to help my young, beautiful wife! She's hurting so bad, physically and spiritually. But she's fighting! She's strong as anyone I know! But her hair falling out, extreme anxiety that can shit her down completely, chronic fatigue, complete shutdown of sexual function, depression, and more. All 4 months after her school forced her to get the mcshot. Developed a nodule on thyroid. Hormones outs whack then normalish again. The Drs were zero help. The only thing that seemed to make a small bit of difference, was one of her Drs put her on ivermectin and LDN (low dose naltrexone) Nothing major, but it calmed her a little and the swings aren't as scary as they were. Please anyone who can help please do so!
Best information ive heard...my Drs know nothing about mcas so no help there...i have almost every symptom...waxes and wanes..miserable stuff...have found nothing that seems to help....so tired of buying so many supplements that dont work but encouraged to try again...
Heal the liver! I used dandelion, milk thistle, artichoke, burdock etc blend off Amazon. Amazing results! Intermittent fasting and regular fasting. Cut alcohol and coffee. Major triggers I know many people are allergic to herbs so… I had a hard time at first but after a while I was able to use some herbs. I use bromelian with quercetin, turmeric and allerga for reactions rescue.
Glad you found something that works for you! Quercetin makes me itch like crazy. Ironically I found out it has asorbic acid among other histamine related ingredients 😅 FMF Functional Doctor formulation... Mistakes were made 😂 I've had some success with Immunoglobulins, probiotics (bifido blend only!), Berberine and digestive enzymes with HCl. It doesn't clear everything, but at least now I don't sit in hives and chronically itch. I drink stinging nettle tea with meals, and use dead sea salt footbaths which supports the constant magnesium loss. I too cut alcohol over 8 years ago and coffee a few years back. Low hist diet. Also low oxalate as that has been a big trigger for me.
Mast cell activation is also also called cytokine storm you forgot to mention CBD stops cytokine storm NAC or n acetyl cystine stop cytokine storm and aspirin helps prevent platelet clotting
Thank you so much, Dr. Paul I can live healthier and more free just with this one video you made! This has cleared up much confusion for me about debilitating histamine reactions you’ve shined a light 💡for me
I left my drs office crying and angry last week. I believe I have MCAS. But because Im diagnosed with bipolar disorder, I was told I need to see a psychiatrist. I've had issues with all sorts of symptoms since childhood. I'm researching to see where to go from here.
There is some research showing that MCAS and autoimmunity can be linked to trauma. Sometimes a mind body approach helps like Dr. Sarno The Mindbody prescription
I’m so sorry, that is awful. I have a chronic pain syndrome, so I’m just told “it’s all in my head”.. Doctors can be so insensitive & I hope and pray you find a doctor that will listen to you, and hear you! 🩵🙏🏻
The bipolar disorder could be connected to the MCAS. There is a book called Brain Energy wrotte and by I believe a neuro psych. He believes mental conditions are caused by brain inflammation and this can be cauaed by food and toxins. You may find addressing your diet helps both condtiions. Not an overnight fix and doesnt mean you stop any meds or other treatmenta but this can help at the root level and allow for healing to begin. Lastly im sorry you aremt being listened to. It is horribly defeating.
2:15pm very important to avoid foods that trigger histamine in your body. Everyone is a little different from each other. Find out which foods trigger histamine. Then use supplements to heal. If you keep eating trigger foods your waisting your time + your money.
since I moved 8 years ago to where I live , Im always allergic! I recently got diagnosed with Ulcerative Colitis . and now broken out in a super itching rash . my colitis is not under control since August . I have had Dermatomyositis since 1991. And I have hashimotos also . I am r taking most of these supplements but dont think they do well in my gut , cause of my constant diarrhea. I have lost 20 lbs . and have no energy
Thanks for this video, Dr. Anderson! Appreciate it. You have such a wealth of knowledge. Would be great to see you do a video on different forms of B1 and even, synthetic forms of B1, such as Benfotiamine and its role in helping with MCAS.
Dr. An, you are the best teacher. I can understand what you say, and being deep in a Mast cell storm, it's not easy to make sense of anything at all. I month ago I added estrogen replacement cream from soy and accidentally put myself into a MCAS storm that I thought would kill me. ...and here you just confirmed what I feared. Estrogen caused it. Thank you!! Thank God for you❤❤❤ God bless you for sharing this info with TH-cam 🎉❤🙏🌻 God bless you for helping me 😊 🙏❤
I tried fasting and it’s the first time I was triggered without food. Atrial fibrillation . I googled it and it said the body sees fasting as stress and stress triggers histamine .
Very insightful. I’ve been taking vitamins like tri-magnesium, D3, and a B complex (sometimes curcumin & mushroom complex) to take the edge off of my pain symptoms where pharmaceuticals have not been successful. Your wisdom was very helpful in opening my eyes to new vitamins I can look into adding to my blend. Thank you! And good luck to anyone experiencing pain, hang in there 🤍
This was an amazing explanation. Honestly best video on this subject that I’ve seen. Curious about your thoughts on those using peptides such as BPC-157! on one hand, heard it’s helpful for the brain-fog aspect, and on the other hand, have heard it can trigger histamine release.. wondering if you’ve ever used it in your practice or what your thoughts on these alternative therapies are?
I'm so grateful for you, amazing informative help here such a complex issue for us who have been suffering for decades trying this and that truly only leads to the same outcome..And so I am truly grateful for your work and thankyou Dr. For being part of the solution unlike all of the other so called experts....Respect.
Seeking gurus like you is the only solution to living a healthy life. Conventional docs only prescribe conventional meds with side effects. Your holistic and alternative meds approach is the only way to overcome MCA s.
Thank you Dr Anderson. Your videos are very helpful. I expect I shall have to watch this one a few more times to understand the pathways more. I really appreciate that you do this for us who struggle to find Drs who understand our condition. Spring tree pollen, peri menopause plus stress have sent my mast cells into battle and I’m losing at the moment. Hopefully I can get out of this flare soon.
Thank you for the info! I'm already taking some of these so that's great! I will talk to my immunologist soon to make sure I can be treated as best we can!
I have Secondary Mast Cell Activation Syndrome with key triggers of six types of sulphites (sulphites Canadian ... sulfites American). Included in this list is Sulphur Dioxide gas (S02) which is emitted by diesel fuel burning trucks on the road. If driving a single lane road behind a diesel burning truck then I just pull over and wait. I worked in the marine industry with tones upon tones of diesel fuel was burnt and inhaled every day of my career. Did you know that the commercial dehydration process sprays sulphur dioxide gas over all the products to prevent mold.
@@laracwass9543 Hi Lara, sorry to hear about your ailment. I'm now 66 y.o. and have had this since my 40's ... well before anyone knew what it was. In my case, I have mcas, am histamine intolerant, have a sulphites trigger and have several other immune system ailments such as IBS, intestinal ulcers, kidney disease, etc. I have researched my condition extensively for many years. I'm Canadian and Health Canada lists Sulphites as a top 10 food allergen. I take the allergen all the way to anaphylaxis. I break out in full body psoriasis during an attack and even develop narcolepsy and sleep up to 4 days without waking. Today, my diet is sulphite free (and that is complicated) and histamine limited. I take prednisone long term but just at a dosage that suppresses my immune system and no more. I take mondafinil to suppress the narcolepsy and this allows me to stay awake during the day. I take candesartan for hypertension. I take cyclobenzaprine as a muscle relaxant. And I take quetiapine for a few days whenever my meds are changed as I typically have psychotic episodes. I meet with my medical team every 2-weeks virtually and have for roughly 1.5 years. I have recently been reassigned to a new to me clinic while I await referrals to 4 specialists. Lara, I hope my story helps you with your journey. At least you now know there is someone else.
When I eat the wrong things, I get severe epigastric pain along with vomiting and diarrhea which is quite severe. The epigastric attacks are so so so painful. I developed this issue 8 years ago after a good poisoning episode. I'm also on immunosuppresants due to an organ transplantation which was 9 years ago. Recently even my safe food is causing such episodes. I cannot eat any kinds of fruits, salads, bread, crumpets, cereal. I struggle during breakfast as I cannot eat much. However all the unhealthy food I can eat. I'm becoming diabetic and struggling with low sugar levels and not having healthy food to snack on. A lovely consultant diagnosed me with Mcas through a sample of my biopsy. I only just started probiotics. I feel the anti histamine causes me more problems or more sensitivities. Unfortunately this isn't recognised in the UK and I happened to come across this consultatant who was from another country who decided to do research into this area. Any help? Today I are yoghurt and granola and now I've been in pain for hours. I get the epigastric pain severely and migraines. Thank you
Very sorry for your suffering. I too can no longer eat raw veggies and very little fruit. .mostly just blueberries. I have eaten healthy mostly vegetarian most of adult life with large salad of greens every day, legumes, etc. Problem got bad in 2013 with undigested veggies in bowel movements then had breath test diagnosed with SIBO. Then 2015 diagnosed with MCAS. I have had pollen allergies and other allergies since childhood. Now much worse since must stick to cooked veggies and gluten free or bodywide itching and GI issues, diarrhea unbearable. I just saw another video that mentioned exipients in meds can also cause reactions. Ugh that sure would be a nightmare to figure out because I am on so many rx meds for many chronic health problems. At least I found a nurse practitioner who is great and recommended I try LDN. She referred me to a website where drs evaluate you and if it is appropriate they RX the LDN. She said she will then take over prescribing the LDN if it is helpful.
There was a person on here who commented that they fasted 3 days a week and it helped them a lot. If that person sees this, I would like to know more about your experience. Thanks!
I heard you say that fasting can sometimes CLEAR mast cell activation. I am also clearing oxilates because after going carnivore I am sick from dumping. I’ve been fasting for one day. I suddenly started to feel better today!
Thank you for the valuable information .My 16-year-old son is currently struggling with cholinergic urticaria post covid and we are trying to find a more natural treatment than antihistamines.
I drink Stinging Nettle Tea 3-4 times a day as a form of antihistamine. 4-5 during heavy flares. Literature is a bit mixed, but most people report a pretty good response. Personally, I respond as good as otc antihistamines, if not better from it. It also helps reduce oxalate absorption from the foods we eat, which some of us with MCAS struggle with. I drink it with my meals.
I second that on the nettle tea, currently sipping on a brew that I infuse in the fridge for two days. I also use a lot of herbs 14g per quart of water. As a pinch of salt and almost like a mini meal 😄 it’s pretty amazing for my allergies. If I forget, I know about it
I have endometriosis. So the endometriotic lesions produce their own estrogen. Needless to say, I have severe estrogen dominance along with progesterone resistance. With time, the estrogen dominance will just get worse. I hear mast cells also trigger more estrogen production. Simply put, how am I supposed to eliminate all this excess estrogen? I feel like this is impossible without surgically removing the endometriosis lesions from my body. And surgery exacerbates my MCAS big time. In fact, MCAS is probably why I have endometriosis in the first place
@ibinezgirl4623 I realize it’s been nine months since this comment on Dr. Anderson’s video. I too have estrogen dominance, but not endometriosis. I’m always seeking alternative ways to treat my body rather than pharmaceuticals or surgery. My suggestion is to research diindolymethane. It comes from cruciferous vegetables to help regulate estrogen. It may not be the exact answer, but it may lead you to something similar to will work.
Would it be possible to eventually find a natural replacement for fexonfedone? Health care in the US is so expensive and for another year I’m set but after that I have to figure other stuff out.
high oestrogen triggers mine , leading up to ovulation and before my period , horrible symptoms , congestion, dizzy , nausea, insomnia, itchy burning eyes, itchy skin , foggy brain, ringing ears , bloating ,
Got worse with me too. Now after three months low histamine dieet and supllements, it is gone. Even severe PMS and bleeding. And i ate very healthy. Not much sugar and processed stuff. I was making myself very sick with loads of healthy vegs and fruits.
I did the methylfolate and methylcobalamin route, and it solved my symptoms for a long time, but it's been coming back recently really bad. I guess I just found out why....
I have been taking most of what you've just outlined for years. when I say this to my primary doctor ( i've had many ) they just glaze over. I am 78 and was just diagnosed with MCAS! I've always known that my problems had a source.
I'm 78 and was diagnosed with MCAS in 2019 after 10 years of searching with numerous specialists. My skin is the main problem, with so much inflammation
*How much B5, B6, C, and magnesium do you recommend in daily supplements, please?* I took a Thorne gut test that revealed I'm low in the bacteria that produce B vitamins which is likely the cause of my histamine issues from what I understand you're saying. Thank you!
A nutritionist gave me histamine diet before I was diagnosed. So by the time this dr told me ai said oh I already do it. I knew it helped me a lot with loads of symtoms but.. I see it as a temporary solution. Can someone told me if he said B12 is bad? I didnt get that part, I always have it high in my What about estrogen medications could it help?
I have MCA's. My dizziness and brain fog is really bad after eating bacon and cheese. And canned fish. How or what do I take to calm my dizziness and brain fog. I've got tumeric I need to get quercetin and dk2. What will help with my brain fog and dizziness? Please help Dr. Thanks Kind regards Lee P.s I've been diagnosed with this since I had COVID 2 years ago. I also have autoimmune dieses.
So if someone is having symptoms from Histamine that are brain related what do they need to do for histamine-aldehyde? Does this explain why DAO supplements don't help some people? Can you point to a single supplement that would help reduce histamine-aldehyde especially if they have a slow MAO mutation? Something formulated for HNMT pathway support vs. DAO support? It seems like all these cofactors that I try just make me feel worse, especially any kind of B vitamin. Just looking for something straight forwards to try. Thanks!
Thank you so much Sir ! Have been in a burnout a year and half ago and developed, along with GI issues, visceral tensions since.. is it part of the MCAS ? Thank you
Thank you for this! Question/advice: are there blood test that can be done for MCAS? Lastly, I have my DNA mutations from Promethease; I have histamine intolerance, vdr, mthfr maoi mutations… can you recommend a doctor that can help me with all these results? Thank you!
My doctor insists I take NAC for detoxing mold. Diagnosed with Lyme, Mold, and MCAS.I tried it several times. My heart hurts, I can't breath and feel like I'm going to pass out. I start sneezing and coughing. Trouble breathing, sweating. Tightness of chest. I also get a rash when I take it. I've heard a lot of people react negatively to NAC with MCAS and Mold toxicity. I'm on binders, a Lot of supplements as prescribed. and also LDN. What else can I try? I had CRLA and I would sweat, feel extremely tired, brain fog, pain and trouble breathing.
Trouble breathing can be dangerous, please make sure you are properly managed by your physician. Dr. A and his team can't answer any medical questions specifically on this channel. You can find referral links to integrative providers in the channel description. -Team Dr. A
What a useful, easy to understand, short to the point video! I have been aware of my MCAS only a month. my naturopath already has me taking some of these - and they are helping calm my terrible itchy inflamed skin rash. I’ll be mentioning the others to her so we can explore some additional options to bring things under control even more. Ultimately the goal is to I.D. what we can heal internally so the symptoms naturally resolve.
@@sailuvijl6621 there is no definitive test, some providers will “test” by seeing how your symptoms respond to an antihistamine. From there your provider will likely start to help you determine your triggers and treat underlying conditions (viral load, infections that are latent, gut issues, mold, nutrient deficiencies, etc.) that have caused overload in your system and need resolving to calm your mast cell response.
I been diagnosed with mcas, they gave me a bunch of antihistamines and basically said good luck.....I've been on my own trying to figure out wth is going on for years now.... it suckkkkssss
I’ve started to get severe reactions to foods out of nowhere causing severe asthma symptoms..Not only to high histamine foods but now gluten and all sorts of foods. Waiting for results for sibo/leaky gut as functional Dr thinks it could be high estrogen as I’m peri menopausal. I can’t eat much besides eggs n meat - so so frustrating and depressing. Has anyone suffered respiratory issues to do with histamine intolerance?
yes, after a long time without symptoms, I experienced air hunger, increased pulse, and morning headaches from eating yogurt daily. I do best on near-carnivore low histamine diet (nothing processed, slow-cooked, leftovers etc - fresh proteins, a few plant items like seasonings, coffee, onions)
Yes and my allergist put me on Ketotifen. Haven't needed an inhaler in years. I got mcas after an allergic reaction to a flu shot in 2013. Ketotifen has to be compounded by a compounding pharmacy here in the United States. Prescribed by a doctor.
how can i get the right vitamin C, I heard ascorbate sucks and the acerola triggers IC. When I take vitamin D3 I feel drugged (maybe I'm lacking K2 and MG so too much calcium gets in the bloodstream) until I take K2. Magnesium glycenate also makes me feel drugged. Magnesium citrate doesn't but I hope it won't aggravate IC.
Regular asorbic acid ( vit c). Will aggravate hives. I have a powdered calcium ascorbate ( it’s a vit c buffered with calcium). It’s great, mixes in water easy. .
1. histamine modulation 2. vit D and K2 3. curcumin 4. flavinoids 5. low dose naltrexone
Fabulous and intelligently summarized list. Thanks a lot.
Thank you! My LC brain got overwhelmed with all the words.
too bad curcumin will destroy your libido if you are a man...
the idea is you watch the video!!
Vit d and k2 actually trigger me :( maybe if i take super small doses?
I feel like you explain everything my immunologists have told me over years in ten minutes, and with more detail and logic. Thank you!
what are the 5? i didn’t follow very well.
Agree
See the other message, it it listed.
I've had MCAS for almost thirteen years now and your the first person to explain it so i understand it. Thank you very much!
excellent explanation.....very understandable ...thank you so much
Thank you! Wow, seeing this 10 years ago would have saved a career. Ten years of trial and error later with various doctors and supplements, and I still learned something here. What a blessing.
My daughter got a virus ib 7th grade and Covid last year. It set off pots and she hasn't been to school in 5 years. She had a procedure and I told the anesthesiologist that she needed steroids wuth her anesthesia. She did not do it. My daughter ended up in ER 15 times and hospitalized 4. She almost had to get a feeding tube. She just kept screaming "the confusion!" Broke my heart. She's on Allegra and Pepcid and going to start Xolair. We've been homebound 14 minths since procedure. She's never had a summer her whole teen years. 😢
Oh my gosh that is terrible….have you tried (slowly) Vitamin B1? And magnesium (B1 uses magnesium)
I just heard of dr Dietrich Klinghardt and Connie Fox. Please research them. They may be able to help you. As always Prayers are first and foremost. I pray she gets well.
Breaks my heart to hear kids going through these things. I hope she was not vaxxinated by c0vid shot. There' s a great ND/Functional medicine doctor in California (San Diego) Dr. Pedi Mirdamadi from Oasis Health Medicine.
@@DoubleOhSilver B1 can cause anxiety and jittery feelings as well as intense sweating if your sensitive to it. Also when you use ANY synthetic vitamin (particularly B vitamins) they can build up in your system and cause neurological problems
Pots?
Why are there (not) a million subscribers to this channel? ❤
Right!? Thanks for your support. :)
- Team Dr. A
Because we're worth more sick, unfortunately.
@@DrA-OnlineI absolutely am at the histamine aldehyde stage 😭 I've been unable to treat for 5 years because I can't tolerate most supplements. I'm beyond terrified (which then makes my mcas and histamine worse being in such a high stress state). Can I just start with b1 or do I need to add the other things further up the chain first? I'm getting sicker and sicker neurologically so have to do something.
You're my MCAS Angel, Dr Paul. Fifty-four years of trying to get help and legitimacy has been a rollercoaster of hope and despair. It all started with a severe case of Mononucleosis at age six. Wish more Doctors would listen to these TH-cam videos for a lil education. Thank you for making my life better with your concise information that has done more for me in the last year than anyone else has ever done. Blessings upon you.
Have you had low vitamin D by any chance throughout your life? What about IBS-like symptoms?
Yes and yes
@@nford3886
Thanks for replying. Could you share by any chance what has worked the most for you? Also, have you had problems with severe anxiety throughout your life?
Some info from my end: know that “MCAS” is a presentation with an imbalanced T-helper 2 (“Th2) cell response compared to Th1, and that fairly recently T regulatory cells have been discovered, which produce cytokines which act like a negative feedback to the inflammatory Th1 and Th2 response, and these Treg cells get upregulated by proper vitamin D availability. Studies on hunter-gatherers show consistently that they have about 45ng/ml of 25-hydroxy vitamin D in their blood, and these people don’t seem to have allergies or immune dysfunction. This high serum vitamin D level by being outside might be a key to this, alongside many different other factors, but vitamin D is notoriously low in Western populations. Thus, sunbathing or supplementation of vitamin D3 (+K2 MK-4) and magnesium for activation of D3 might drastically help with stabilizing these overzealous mast cells. Fat soluble vitamins are synergistic so you might want to look into vitamin A as well, given that this is also a very immune-related vitamin and some people (those with BCMO1 gene polymorphisms) might need specific animal sources such as liver or cod liver oil to get enough of it, because they have difficulty getting it from plant pigment (beta-carotene).
Another thing to know is that chronic stress due to anxiety disorders, trauma, unhealthy social or work situations, etc. cause chronic corticotropin releasing hormone secretion, which drastically activate mast cells. It is therefore no surprize that people with chronic (idiopathic) urticaria often see this condition appear after periods of chronic psychological stress, and see them disappear when their psychological state is normalized. Also, this is a positive feedback loop, as MCAS can cause anxiety via many different direct and indirect ways. Vicious cycle.
Good luck. Hope it’s helpful.
Fix the brain you fix mcas 🤜 it’s an over protective brain reacting to everything.
@@marycolhenry can I ask you some questions about this? Do you have personal or patient experience with this?
I found this fascinating! My husband and daughter just had a ton of testing and go for their follow up with a MCAS specialist next month. But the methylation issue rings very true for my husband. Methyl folate causes him to spiral into depression very fast and hard. It’s SCARY! Definitely a toxic reaction in the brain. I will try thiamine to see if we can unplug that pathway. Thank you so much for this series! It’s very, very helpful!
Did it help?
Does he have pain fybromyalgia symptoms
Yes, please update us!
Please update us!!
Need to know how to help my young, beautiful wife! She's hurting so bad, physically and spiritually. But she's fighting! She's strong as anyone I know! But her hair falling out, extreme anxiety that can shit her down completely, chronic fatigue, complete shutdown of sexual function, depression, and more. All 4 months after her school forced her to get the mcshot. Developed a nodule on thyroid. Hormones outs whack then normalish again. The Drs were zero help. The only thing that seemed to make a small bit of difference, was one of her Drs put her on ivermectin and LDN (low dose naltrexone)
Nothing major, but it calmed her a little and the swings aren't as scary as they were.
Please anyone who can help please do so!
@@adamwhitfield5571 see a naturopath r functional medicine doctor
Best information ive heard...my Drs know nothing about mcas so no help there...i have almost every symptom...waxes and wanes..miserable stuff...have found nothing that seems to help....so tired of buying so many supplements that dont work but encouraged to try again...
Heal the liver! I used dandelion, milk thistle, artichoke, burdock etc blend off Amazon. Amazing results! Intermittent fasting and regular fasting. Cut alcohol and coffee. Major triggers
I know many people are allergic to herbs so… I had a hard time at first but after a while I was able to use some herbs.
I use bromelian with quercetin, turmeric and allerga for reactions rescue.
Can you tell me your regimen...I know we are all different but I just want to know where to start
Glad you found something that works for you!
Quercetin makes me itch like crazy. Ironically I found out it has asorbic acid among other histamine related ingredients 😅 FMF Functional Doctor formulation... Mistakes were made 😂
I've had some success with Immunoglobulins, probiotics (bifido blend only!), Berberine and digestive enzymes with HCl. It doesn't clear everything, but at least now I don't sit in hives and chronically itch. I drink stinging nettle tea with meals, and use dead sea salt footbaths which supports the constant magnesium loss. I too cut alcohol over 8 years ago and coffee a few years back. Low hist diet. Also low oxalate as that has been a big trigger for me.
@@JamieR can you tell me the kind of probiotic like brand name
Do you have pain
I would love to drink coffee again!
Mast cell activation is
also also called cytokine storm you forgot to mention CBD stops cytokine storm NAC or n acetyl cystine stop cytokine storm and aspirin helps prevent platelet clotting
Dr. Paul Anderson you are an absolute angel. Thank you so much.
Association between MTHFR & MCAS.
You have a incredible way of breaking down something very complex and making it sound simple great job DR.
Thanks for the support!
In your opinion is MCAS curable or is something that has to managed over a lifetime. @@DrA-Online
Thank you so much, Dr. Paul I can live healthier and more free just with this one video you made!
This has cleared up much confusion for me about debilitating histamine reactions you’ve shined a light 💡for me
Love Seeking Health and Dr. Ben Lynch. Thanks for mentioning this company.
I left my drs office crying and angry last week. I believe I have MCAS. But because Im diagnosed with bipolar disorder, I was told I need to see a psychiatrist. I've had issues with all sorts of symptoms since childhood. I'm researching to see where to go from here.
There is some research showing that MCAS and autoimmunity can be linked to trauma. Sometimes a mind body approach helps like Dr. Sarno The Mindbody prescription
I’m so sorry, that is awful.
I have a chronic pain syndrome, so I’m just told “it’s all in my head”..
Doctors can be so insensitive & I hope and pray you find a doctor that will listen to you, and hear you! 🩵🙏🏻
@@ronnie-lynn Have you tried chiropractic?
The bipolar disorder could be connected to the MCAS. There is a book called Brain Energy wrotte and by I believe a neuro psych. He believes mental conditions are caused by brain inflammation and this can be cauaed by food and toxins. You may find addressing your diet helps both condtiions. Not an overnight fix and doesnt mean you stop any meds or other treatmenta but this can help at the root level and allow for healing to begin. Lastly im sorry you aremt being listened to. It is horribly defeating.
@@tiffanybooth1563 thank you.
Simple and informative. Coming from someone eismans after covid have ruined my heath And life
2:15pm very important to avoid foods that trigger histamine in your body. Everyone is a little different from each other. Find out which foods trigger histamine. Then use supplements to heal. If you keep eating trigger foods your waisting your time + your money.
FIX THE NERVOUS SYSTEM! Calm the stress response! I REVERSED MCAS 😊
How did you do this?
Happy to hear it!
Team Dr A
Stay tuned for future videos. We recommend finding a good integrative doctor you gel with. Check referral links in video description.
Team Dr. A
Limbic system work
what did you take to fix it?
So very helpful! Thank you for your generosity of knowledge and helping so many people.
since I moved 8 years ago to where I live , Im always allergic! I recently got diagnosed with Ulcerative Colitis . and now broken out in a super itching rash . my colitis is not under control since August . I have had Dermatomyositis since 1991. And I have hashimotos also . I am r taking most of these supplements but dont think they do well in my gut , cause of my constant diarrhea. I have lost 20 lbs . and have no energy
Thanks for this video, Dr. Anderson! Appreciate it. You have such a wealth of knowledge. Would be great to see you do a video on different forms of B1 and even, synthetic forms of B1, such as Benfotiamine and its role in helping with MCAS.
Thank you for the information, my allergist had no idea what to do with me.
Great summary. Thank you. As someone who helps manage an MCAS support group, I'll be showing this to all our new members.
What group?
Extremely helpful information, so here's to hoping the algorithm looks upon your channel favorably!
would someone mind listing the 5 he suggests? maybe it’s me, but i’m having a difficult time following.
Dr. An, you are the best teacher. I can understand what you say, and being deep in a Mast cell storm, it's not easy to make sense of anything at all. I month ago I added estrogen replacement cream from soy and accidentally put myself into a MCAS storm that I thought would kill me. ...and here you just confirmed what I feared. Estrogen caused it. Thank you!! Thank God for you❤❤❤ God bless you for sharing this info with TH-cam 🎉❤🙏🌻 God bless you for helping me 😊 🙏❤
Stay away from Seed oils.
I've had it for two years and extended fasting healed it for me. I did two 36 hour water fasts in three days and it was like flipping a switch.
Amazing.
I tried fasting and it’s the first time I was triggered without food. Atrial fibrillation . I googled it and it said the body sees fasting as stress and stress triggers histamine .
Such good information! I’m so grateful for your videos especially this one with streamlined suggestions in vitamins.
Very insightful. I’ve been taking vitamins like tri-magnesium, D3, and a B complex (sometimes curcumin & mushroom complex) to take the edge off of my pain symptoms where pharmaceuticals have not been successful. Your wisdom was very helpful in opening my eyes to new vitamins I can look into adding to my blend. Thank you! And good luck to anyone experiencing pain, hang in there 🤍
This was an amazing explanation. Honestly best video on this subject that I’ve seen. Curious about your thoughts on those using peptides such as BPC-157! on one hand, heard it’s helpful for the brain-fog aspect, and on the other hand, have heard it can trigger histamine release.. wondering if you’ve ever used it in your practice or what your thoughts on these alternative therapies are?
Will pass this along for possible videos, thanks for your comment - Team Dr. A
@@DrA-Online Of course and thank you for your reply back. Just subscribed! Looking forward to you potentially making a video on this.
Dr. Michael Robinson said you are awesome !
Good to hear! Thanks for the support. - Team Dr. A
I'm so grateful for you, amazing informative help here such a complex issue for us who have been suffering for decades trying this and that truly only leads to the same outcome..And so I am truly grateful for your work and thankyou Dr. For being part of the solution unlike all of the other so called experts....Respect.
This is great! I developed MCAS after food poisoning. It's great information I will take TO MY DOCTOR!
You mean Parasites
very concise and informative
Seeking gurus like you is the only solution to living a healthy life. Conventional docs only prescribe conventional meds with side effects. Your holistic and alternative meds approach is the only way to overcome MCA s.
Thank you Dr Anderson. Your videos are very helpful. I expect I shall have to watch this one a few more times to understand the pathways more. I really appreciate that you do this for us who struggle to find Drs who understand our condition. Spring tree pollen, peri menopause plus stress have sent my mast cells into battle and I’m losing at the moment. Hopefully I can get out of this flare soon.
Thanks
Thank you for your videos. I’m learning a lot.
Quercetin with Zinc is very important by MCAS.
😮 Brain overload. Will look through again thanks Doc.
I would really appreciate if someone can put this in summary
Thank you for the info! I'm already taking some of these so that's great! I will talk to my immunologist soon to make sure I can be treated as best we can!
Thank you so much. Need this help. Praying my Strategene helps dial this in for me even more. Tysm Doc
I have Secondary Mast Cell Activation Syndrome with key triggers of six types of sulphites (sulphites Canadian ... sulfites American). Included in this list is Sulphur Dioxide gas (S02) which is emitted by diesel fuel burning trucks on the road. If driving a single lane road behind a diesel burning truck then I just pull over and wait. I worked in the marine industry with tones upon tones of diesel fuel was burnt and inhaled every day of my career.
Did you know that the commercial dehydration process sprays sulphur dioxide gas over all the products to prevent mold.
how did you find this out!? My MCAS is out of control and i'm not responding to many medications
@@laracwass9543 Hi Lara, sorry to hear about your ailment. I'm now 66 y.o. and have had this since my 40's ... well before anyone knew what it was. In my case, I have mcas, am histamine intolerant, have a sulphites trigger and have several other immune system ailments such as IBS, intestinal ulcers, kidney disease, etc. I have researched my condition extensively for many years. I'm Canadian and Health Canada lists Sulphites as a top 10 food allergen. I take the allergen all the way to anaphylaxis. I break out in full body psoriasis during an attack and even develop narcolepsy and sleep up to 4 days without waking. Today, my diet is sulphite free (and that is complicated) and histamine limited. I take prednisone long term but just at a dosage that suppresses my immune system and no more. I take mondafinil to suppress the narcolepsy and this allows me to stay awake during the day. I take candesartan for hypertension. I take cyclobenzaprine as a muscle relaxant. And I take quetiapine for a few days whenever my meds are changed as I typically have psychotic episodes. I meet with my medical team every 2-weeks virtually and have for roughly 1.5 years. I have recently been reassigned to a new to me clinic while I await referrals to 4 specialists. Lara, I hope my story helps you with your journey. At least you now know there is someone else.
@@warrenpeterson6065hope u find answers n get better
@@warrenpeterson6065curious whether you had a traumatic childhood?
@@revelation12_1 Hi Revelation, Yes, I experienced severe trauma over many years as a child ... 3 of which are missing from memory.
Anne Maitland , Dr Castels , Dr Afrin.
Can you please reccomend someone in uk a functional medical doctor,they are not too common here thanks for the help and videos
When I eat the wrong things, I get severe epigastric pain along with vomiting and diarrhea which is quite severe. The epigastric attacks are so so so painful. I developed this issue 8 years ago after a good poisoning episode. I'm also on immunosuppresants due to an organ transplantation which was 9 years ago.
Recently even my safe food is causing such episodes. I cannot eat any kinds of fruits, salads, bread, crumpets, cereal. I struggle during breakfast as I cannot eat much. However all the unhealthy food I can eat. I'm becoming diabetic and struggling with low sugar levels and not having healthy food to snack on.
A lovely consultant diagnosed me with Mcas through a sample of my biopsy. I only just started probiotics. I feel the anti histamine causes me more problems or more sensitivities.
Unfortunately this isn't recognised in the UK and I happened to come across this consultatant who was from another country who decided to do research into this area.
Any help? Today I are yoghurt and granola and now I've been in pain for hours. I get the epigastric pain severely and migraines. Thank you
Make sure to connect with a local integrative doctor for help, check the links in video description to find a good doctor.
-Team Dr. A
Very sorry for your suffering. I too can no longer eat raw veggies and very little fruit. .mostly just blueberries. I have eaten healthy mostly vegetarian most of adult life with large salad of greens every day, legumes, etc. Problem got bad in 2013 with undigested veggies in bowel movements then had breath test diagnosed with SIBO. Then 2015 diagnosed with MCAS. I have had pollen allergies and other allergies since childhood. Now much worse since must stick to cooked veggies and gluten free or bodywide itching and GI issues, diarrhea unbearable. I just saw another video that mentioned exipients in meds can also cause reactions. Ugh that sure would be a nightmare to figure out because I am on so many rx meds for many chronic health problems. At least I found a nurse practitioner who is great and recommended I try LDN. She referred me to a website where drs evaluate you and if it is appropriate they RX the LDN. She said she will then take over prescribing the LDN if it is helpful.
You should eliminate common triggers like gluten. Get off bread and anything that contains gluten like oats, wheats, barley, rye.
What if my stomach is sensitive to herbs? Curcumin is kind of spicy. Even quercetin hurt my stomach. Anything that hurts my stomach makes things worse
There was a person on here who commented that they fasted 3 days a week and it helped them a lot. If that person sees this, I would like to know more about your experience. Thanks!
Thank you Dr. Anderson for these helpful informationand best regards from Germany
Incredible video 🔥 thank you so much!🧡
thanks, high speed analysis. better than those 1 hour ramblings!
I heard you say that fasting can sometimes CLEAR mast cell activation. I am also clearing oxilates because after going carnivore I am sick from dumping. I’ve been fasting for one day. I suddenly started to feel better today!
I've ended up in the hospital due to fasting and too much water.
Thanks so much.. great info and clearly expressed .. brilliant 😃
Thank you for the valuable information .My 16-year-old son is currently struggling with cholinergic urticaria post covid and we are trying to find a more natural treatment than antihistamines.
Try bee propolis? Bee purga ingested. And I apply holy basil essential oil on my rashes. It gives me relief. Yes and take quercetin also
I drink Stinging Nettle Tea 3-4 times a day as a form of antihistamine. 4-5 during heavy flares.
Literature is a bit mixed, but most people report a pretty good response. Personally, I respond as good as otc antihistamines, if not better from it.
It also helps reduce oxalate absorption from the foods we eat, which some of us with MCAS struggle with. I drink it with my meals.
Thank you!@@JamieR
I second that on the nettle tea, currently sipping on a brew that I infuse in the fridge for two days. I also use a lot of herbs 14g per quart of water. As a pinch of salt and almost like a mini meal 😄 it’s pretty amazing for my allergies. If I forget, I know about it
I have endometriosis. So the endometriotic lesions produce their own estrogen. Needless to say, I have severe estrogen dominance along with progesterone resistance. With time, the estrogen dominance will just get worse. I hear mast cells also trigger more estrogen production. Simply put, how am I supposed to eliminate all this excess estrogen? I feel like this is impossible without surgically removing the endometriosis lesions from my body. And surgery exacerbates my MCAS big time. In fact, MCAS is probably why I have endometriosis in the first place
@ibinezgirl4623 I realize it’s been nine months since this comment on Dr. Anderson’s video. I too have estrogen dominance, but not endometriosis. I’m always seeking alternative ways to treat my body rather than pharmaceuticals or surgery. My suggestion is to research diindolymethane. It comes from cruciferous vegetables to help regulate estrogen. It may not be the exact answer, but it may lead you to something similar to will work.
DIM supplements and progesterone have helped me a lot.
Would it be possible to eventually find a natural replacement for fexonfedone? Health care in the US is so expensive and for another year I’m set but after that I have to figure other stuff out.
high oestrogen triggers mine , leading up to ovulation and before my period , horrible symptoms , congestion, dizzy , nausea, insomnia, itchy burning eyes, itchy skin , foggy brain, ringing ears , bloating ,
:(
Same sadly
Got worse with me too. Now after three months low histamine dieet and supllements, it is gone. Even severe PMS and bleeding.
And i ate very healthy.
Not much sugar and processed stuff.
I was making myself very sick with loads of healthy vegs and fruits.
Same as me 😢
Such great info and explained so well! Thanks Dr A!
I did the methylfolate and methylcobalamin route, and it solved my symptoms for a long time, but it's been coming back recently really bad. I guess I just found out why....
so I have histamine intolerance and have to take L-methylfolate because of 2 MTHFR gene mutations, what do I do???
I also have this question!
Thank you for all the great information
Lovely and very helpful doctor.
Very helpful. Many thanks
Glad you like it, thanks for the support.
-Team dr. A
Very informative and interesting!
Such great information! Thank you!
I have been taking most of what you've just outlined for years. when I say this to my primary doctor ( i've had many ) they just glaze over. I am 78 and was just diagnosed with MCAS! I've always known that my problems had a source.
I'm 78 and was diagnosed with MCAS in 2019 after 10 years of searching with numerous specialists. My skin is the main problem, with so much inflammation
very clear discussion - thank you
I was just now put on methylated vitamins and am in a huge mast flare along with covid for almost a month. Thank you so so much.
Do you mean one shouldnt get in methylated B vitamins if one suspects MCAS especially after Covid?
Great explained!
*How much B5, B6, C, and magnesium do you recommend in daily supplements, please?* I took a Thorne gut test that revealed I'm low in the bacteria that produce B vitamins which is likely the cause of my histamine issues from what I understand you're saying. Thank you!
A nutritionist gave me histamine diet before I was diagnosed. So by the time this dr told me ai said oh I already do it. I knew it helped me a lot with loads of symtoms but.. I see it as a temporary solution.
Can someone told me if he said B12 is bad? I didnt get that part, I always have it high in my
What about estrogen medications could it help?
I have MCA's. My dizziness and brain fog is really bad after eating bacon and cheese. And canned fish. How or what do I take to calm my dizziness and brain fog. I've got tumeric I need to get quercetin and dk2. What will help with my brain fog and dizziness? Please help Dr. Thanks
Kind regards Lee
P.s I've been diagnosed with this since I had COVID 2 years ago. I also have autoimmune dieses.
Thank you so so much for this information! Wondering your thoughts on taking levothyroxine while doing this?
Thank you!! This was super helpful!
What brand, or form of B vitamins, & magnesium do you recommend for someone who is extremely sensitive to everything?
So if someone is having symptoms from Histamine that are brain related what do they need to do for histamine-aldehyde? Does this explain why DAO supplements don't help some people? Can you point to a single supplement that would help reduce histamine-aldehyde especially if they have a slow MAO mutation? Something formulated for HNMT pathway support vs. DAO support? It seems like all these cofactors that I try just make me feel worse, especially any kind of B vitamin. Just looking for something straight forwards to try. Thanks!
Try checking out his other videos on MCAS, and otherwise chatting with your integrative provider could help bring clarity - Team Dr. A
Such useful info Dr A
Thank you, an extremely helpful video!
Thank you so much Sir !
Have been in a burnout a year and half ago and developed, along with GI issues, visceral tensions since.. is it part of the MCAS ? Thank you
Great info. Thanks.
Excellent explanation ! Thank you so much for helping those of us with such a complex disorder.
Can taking DAO supplements improve slow MAO? I have slowest version of MAO-A (warrior gene).
Respen-a increases slow mao-a
Is he saying that if you have the gene mutation for MTHFR and take a methylated b vit and if you take H1 & H2 blocker you’ll make your mcas worse?
This was so helpful- thank you. Can I take K2 when I am on Apixaban please.
Thank you for this! Question/advice: are there blood test that can be done for MCAS? Lastly, I have my DNA mutations from Promethease; I have histamine intolerance, vdr, mthfr maoi mutations… can you recommend a doctor that can help me with all these results? Thank you!
What is promethease do you have fybromyalgia I have Asperger's add had or heds sure mcas pain worst for me
My doctor insists I take NAC for detoxing mold. Diagnosed with Lyme, Mold, and MCAS.I tried it several times. My heart hurts, I can't breath and feel like I'm going to pass out. I start sneezing and coughing. Trouble breathing, sweating. Tightness of chest.
I also get a rash when I take it.
I've heard a lot of people react negatively to NAC with MCAS and Mold toxicity. I'm on binders, a Lot of supplements as prescribed. and also LDN.
What else can I try?
I had CRLA and I would sweat, feel extremely tired, brain fog, pain and trouble breathing.
Trouble breathing can be dangerous, please make sure you are properly managed by your physician. Dr. A and his team can't answer any medical questions specifically on this channel. You can find referral links to integrative providers in the channel description.
-Team Dr. A
Thank you.
What a useful, easy to understand, short to the point video! I have been aware of my MCAS only a month. my naturopath already has me taking some of these - and they are helping calm my terrible itchy inflamed skin rash. I’ll be mentioning the others to her so we can explore some additional options to bring things under control even more. Ultimately the goal is to I.D. what we can heal internally so the symptoms naturally resolve.
How did u test mcas
Same question. Please
@@sailuvijl6621 there is no definitive test, some providers will “test” by seeing how your symptoms respond to an antihistamine. From there your provider will likely start to help you determine your triggers and treat underlying conditions (viral load, infections that are latent, gut issues, mold, nutrient deficiencies, etc.) that have caused overload in your system and need resolving to calm your mast cell response.
@@adamwhitfield5571 see my reply to above commenter
Dr Ann Maitland and Dr Afrin and some great talks on testing protocols for MCAS
I been diagnosed with mcas, they gave me a bunch of antihistamines and basically said good luck.....I've been on my own trying to figure out wth is going on for years now.... it suckkkkssss
Find a good integrative provider! Links in description. -Team Dr. A
Maybe candida is a cause of this?
@dra_online is there someone in uk you can reccomend please
@@Çorumlu38 Internal infection is my thoughts
Thank you peter griffin
Thank my daughter in law is suffering from this right now. She can’t get anything.
It makes more sense to remove the parasites first, then see if it's acceptable or not,
I really appreciate how simple this presentation was.
How do I handle and treat heat intolerance???? Going insane.
Omg m2 😱
Extremely useful.
I’ve started to get severe reactions to foods out of nowhere causing severe asthma symptoms..Not only to high histamine foods but now gluten and all sorts of foods. Waiting for results for sibo/leaky gut as functional Dr thinks it could be high estrogen as I’m peri menopausal. I can’t eat much besides eggs n meat - so so frustrating and depressing. Has anyone suffered respiratory issues to do with histamine intolerance?
yes, after a long time without symptoms, I experienced air hunger, increased pulse, and morning headaches from eating yogurt daily. I do best on near-carnivore low histamine diet (nothing processed, slow-cooked, leftovers etc - fresh proteins, a few plant items like seasonings, coffee, onions)
I have Anaphylaxis when histamine gets high
Yes and my allergist put me on Ketotifen. Haven't needed an inhaler in years. I got mcas after an allergic reaction to a flu shot in 2013. Ketotifen has to be compounded by a compounding pharmacy here in the United States. Prescribed by a doctor.
Resp issues go hand in hand with it. Your lungs also have mast cells
Singulair is a prescription drug to help the lungs
If you have reflux what vitamin c can you take ?
Such good advice. Dr. who helped me has left the state, so I am struggling to find anyone who can help with Mast Cell and EDs.
Try the links in video description to find a good integrative provider near you - Team Dr. A
how can i get the right vitamin C, I heard ascorbate sucks and the acerola triggers IC. When I take vitamin D3 I feel drugged (maybe I'm lacking K2 and MG so too much calcium gets in the bloodstream) until I take K2. Magnesium glycenate also makes me feel drugged. Magnesium citrate doesn't but I hope it won't aggravate IC.
Regular asorbic acid ( vit c). Will aggravate hives. I have a powdered calcium ascorbate ( it’s a vit c buffered with calcium). It’s great, mixes in water easy. .
I get the powdered one I mentioned above thru Swanson vitamins.