Cellular Respiration Part 3: The Electron Transport Chain and Oxidative Phosphorylation
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- เผยแพร่เมื่อ 24 ก.ค. 2024
- The trilogy is finally concluded! And with a bang, no less, as this final stage of cellular respiration is the one that provides the big energy payoff for the cell. Let's learn about how the products of the Citric Acid cycle go on to the electron transport chain to facilitate reactions that will generate a proton gradient suitable for powering ATP synthase, one of the most fascinating proteins in the body.
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If only these presentations had been available 40 years ago. I struggled with learning these topics in my late teens. Thanks Dave. Great work!
I know!
Absolutely phenomenal summary. My textbook is great at the nitty gritty details, but I was getting over-whelmed and needed a reminder of the big picture. This is exactly the type of supplemental material I've been looking for, definitely going to subscribe. Thank you so much for the hard work and brilliant explanation!
well put
I owe my entire college degree to this dude
I STILL DONT UNDERSTAND MAN
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@@lenaelhassan5061i passed with flying colors now im suffering with smth worse I HATE THE EXCRETORY SYSTEM
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I feel your pain man. Fck bio bro I aint never using this knowledge in the future anyway
@@justafan5279 the irony is that i wanna be a surgeon 🙂
You have to admit nature is pretty elegant.
sebastian cuello I agree to that. All living beings are like very complex machines if you ask me.
And yet people still don’t believe in a creator and think this all came about “by chance”
@@mahadali619 It wasn't chance. It took billions of years to go from slime to homo sapiens.
@@sccm100 by chance of preferable mutation, no?
@@mahadali619 By the chance of individuals getting random mutations that will favor their survival.
Slime that mutated to eat other slime are now humans.
Most mutations, though, would have made the slime retarded. Only rarely do mutations give you an advantage.
i've been STRESSING over this content bc i have an exam coming up but being able to see the big picture so clearly and concisely has helped me be able to get into the nitty gritty details and still understand what's going on. actual lifesaver!!
I love how he avoided saying powerhouse. Similar to Kyle Hill saying "sweater of space time" in place of fabric.
Thank you. This made me realise how bad my notes were at explaining respiration. Godsend.
He does look a lot like Jesus...
I need to thank you, Dr. Dave but especially a big thanks go to your trillions of enzymes that helped make this possible.
Thanks Professor Dave! Have my final for Bio today and you made it easier to remember this stuff! I appreciate all your hard work!
One again my hats off PROFESSOR DAVE!! I think your 3 PART series on CELLULAR RESPIRATION are TOP NOTCH and I am surprised quite sincerely that these dont have one million views each by now!!
I have listened to MANY different CELLULAR RESPIRATION videos and yours is the clearest and your GRAPHICS and chemical formulas are VERY CLEARLY presented and explained!!
Thanks Prof. Dave!!
Professor Dave, my professor waited until 1 day before our final to tell us we were taking the cumulative ACS biochemistry exam. You are saving my life. Thank you.
These videos are a life send. So detailed and presents the information very clearly! Will definitely use this channel concurrently with my studies!!
Your dynamic animation is suuuuper helpful! Thanks so much!!!
Amazing that only a few elements, forged in stellar furnaces, are arranged into different structures and drive all these processes. Thank you for creating this content, Professor Dave!
wow ! Professor Davie. You helped me in my first year am now watching you in Biochemistry in my second year. Thank you so much.. Continue blessing us 🙏
Dear god thank you I tried teaching myself this for days trying to understand cellular respiration for an exam in my lecture class and no matter what I did I couldn't understand it, it was way too much to take in at once but you explained it so well and the summary of the products from each step was extremely helpful thank you!
i'm forever thankful for you!
Once again, Professor Dave is swooping in to save my finals! 😁
I really love your videos. I'm a freshman college student and your videos help me a lot. a big thank you!
Damn cant believe JESUS just taught me oxidative phosphorylation
Science Jesus says: The Mitochondria is the powerhouse of the cell 😉👍"
Professor Dave coming in clutch as always.
professor Dave is my very first professor crush! he helped me so much on this THANK YOU PROFESSAHHHH YOU'RE THE BEST!
Same, my dude is a genius
Very comprehensive, thanks Prof Dave👏🏾😍
bless you my Dude you're saving lives
It is insane how helpful this was
Broo i was trying so hard to understand this topic and as soon as I saw you have a video on this my half of tension was over thanks Dave sir❤
Thanks prof. Very insightful
“Mitochondria are the powerhouse of the cell” - an exploration.
He said engine of the cell. Totally different.
Is a trade off. Cell gives the bacteria protection in exchange of ATP.
@@VeritasEtAequitas I teach high school BIOLOGY and the ENGINE of the CELL or the POWERHOUSE of the CELL are equivalent descriptions and BOTH are perfectly acceptable!!
You’re the best professor Dave! Been watching you for years now. Sending love from the physics community (I’m here out of curiosity not necessity)!
Thank you sir..... It helped me to understand it so easily and efficiently ❤️
wow.. I am actually able to comprehend this.. GREAT WORK PROF 🥺👌🏽
Thank you professor Dave. Excellent!
Professor Dave is truly the best!
AMAZING!! SAVING STUDENTS LIVES HERE!!!!! Thank you!
Dave is basically the god of knowledge. You want to learn anything form chemistry to italian, you can come here. I love your vids!
I'm taking microbiology right now and this is very useful. I'm 38 and I wish this kind of learning was available along time ago.
stay tuned for my microbiology series, i will start releasing it soon!
@@ProfessorDaveExplains I will hit the notification bell. Thank you
Great explanations of complex ideas
lmao I was just watching one of your videos on Greens Theorem for my calc III class, and now I'm studying for Molecular Cell Bio and your video was the first one to pop up. Amazing scope of knowledge.
Thanks so much!
Absolutely brilliant thank you
Hey Prof, great explanation. My knowledge is simplified just to the chart in my NTP tutorial. Luv & appreciate info abut pro- & -eukaryotes cells going ~ 4 billions years ago when life begins. Tq 4 educating 're Kreb cycle.
Excellent... in all aspects.. thanks 🙏
bless you prof dave
thank you ☺️
You are an awesome teacher!!! thank you so much
thank u so much! gonna pass my biochem test :)
Thank you!
Thank you professor.
Thank you so much
OMG, I have never heard or seen this be tough better than now. Thank GOD for WIFI, TH-cam, and Professor Dave, the Trilogy that helped me understand Cellular Respiration!
interesting video! i would have liked you to explain the whole "watermill" process in ATPsynthase tho, I'm very keen on the field of molecular machines. keep it up!
my Sherla, nice to decipher for 3rd Year Science. (from the Philippines)
It is impressive If 3:44 the whole thing is drawn by you Professor Dave
Amazing
Thanks!
thank you so muchhh
very helpfull when school from home bcs pandemic occured, thank you!
'You have made chemistry a plate of delicacy'.Enjoyed to the utmost fulfillment. Thank you sir.
Thank u ur very clear
Is the mitochondria not more like the refinery? Because it turns the fuel we it in fuel the other parts of the cell can use.
Prof, I sense free energy in this tutorial. They (protein industrial complex 1-4) were able to steal electrons just by virtue of their configuration and able to create charge gradient without consuming any energy. This gradient is later used to create energy in form of cellular energy currency atp. Hence mitochondria is able to make energy without loss of any chemical "potential" energy.
Or, I missed some details?
This video is very well presented and got the main ideas across accurately and clearly; understandably, some things are oversimplified, though. For example, glycolysis produces 1 NADH; this wasn't (clearly) shown in this video and might cause some confusion (in my opinion). Also, pyruvate generates an NADH when it becomes oxidized to become acetyl-CoA. Overall, a very good video. :)
Sir Dave, does excess ATP that is not use by the body can be stored? If yes where it is stored?
ARE THE NADPH AND FADH2 RETURN INTO FAD AND NADP+. SO IF THIS IS THE CASE NADPH AND FADH2 IS NOT CONSIDERED AS BYPRODUCT WHEN THE WHOLE PROCESS ENDS?
he don't miss!!!!
thanks bestie
Thanks
Saved my life! @.@ thanks!
amazing video 100/10 🫶🏻
Great video! Thank u!
What is name of this program which u used to did it?
Especially I want to do something like an animation with H+ started in 2.10min.
adobe after effects!
always save me during science class
Where does the protons come from
I never knew that cellular respiration is as easy as this. Also, now I can finally say with full confidence that my biochemistry teacher in med school is HORRIBLE!!!
Isn't the theoretical yield of ATP 38?
GOAT
Thnk u
s.s ammu up the fuck hell up yiant nobody want you here.
I don't know about foreign but in India we have to learn all that in high school and thank you for making these educational videos
I thought FADH2 becomes FAD not FAD+?
he definitely knows a lot about the science stuff
He does
Currently having from Wachemo university💥✅
Can you explain Aromatic compounds
i did some stuff on aromaticity already! check them out.
I want to ask wheredoes atp syhnthsis take place?? IS in in matrix or inner surface of the innermembrane?? pls someone help me in this🥺🥺
For oxidative phosphorylation, the electron transport complexes are embedded within the inner membrane. ATP synthase, the protein complex that is (actually) synthesizing ATP here is also embedded within the inner membrane. I'm still learning this so take that with a grain of salt, but this is my understanding.
can you also touch upon what are the most critical steps disruption of which could stop the process?
For example, could ETC still work if complex II is broken?
hmm, i would presume that the disruption of any single step anywhere in the process would render the whole cycle impossible!
are complexes 1 and 2 not redundant?
not to my knowledge, but perhaps!
Thank you, Professor Dave :D
@@monacharleston593 did you learn complex 2 is the site of FADH2 oxidation rather than NADH?
plz cover all the topics and information given in our biology books. so that we also understand the book concepts as well.
i will try to do a biology course later this year! gotta finish physics first.
thanks. but do it as fast as possible.Exams are coming .
Professor Dave Explains a biology series would be much appreciated!
Guy Hale I hope
Great, looking forward to that with great anticipation!
Is your 26-28 correct?
I am still baffled on how many ATP per Celluar Resipartion Is it?
30 - 32 ATP (yt vid and some sources)
or
36-38 ATP (some sources)
I wrote him an e-mail with some questions and he never answered! I am a bit disappointed. But I also like those videos
sorry i try to reply to all emails but i get so many that some fall through. if i don't reply it's usually because the email had way too many questions, i don't understand the question, or i just don't know the answer.
You forget about oxygene. Why do we need it?
Oxigen is the final electrons receptor in this chain reaction. You are right, It Is very important, he should have said It.
thank you science jesus
Outstanding teacher.
Each NADH gives 3 ATP
Each FADH gives 2 ATP
(total ATP is 38)
You said in the video that 26-28 ATP can be produced by this chain and the ATP synthase. In my text and a few other videos it says 38 ATP. Can you explain the difference in these numbers? Is it possibly talking (in my text) about glycolysis+Krebs+electron transport chain TOTAL ATP production, and you're only speaking specifically about the electron transport chain?
Hmm, well yes part of it is that I was specifying oxidative phosphorylation, but you're not getting much from the other phases, just two from each, so it's 30-32 total. I'm not sure why someone would say 38, it sounds bogus to me!
@@ProfessorDaveExplains My text book is Microbiology An Introduction, ELEVENTH EDITION, Gerard J. Tortora et. al if that is of any help for reference. It says "In aerobic prokaryotes, 38 ATP molecules can be produced from complete oxidation of a glucose molecule in glycolysis, the Krebs cycle, and the electron transport chain....In eukaryotes, 36 ATP molecules are produced from complete oxidation of a glucose molecule."
Since I made my comment, I have researched other sources as well, and many seem to be conflicting for overall ATP production of a single glucose molecule (in both prokaryotes AND eukaryotes). So odd.
The difference Is because he didn't mention un past videos that in aerobic respiration glycolisis 1 Glucose-->2ATP + 2 NADH. Those 2 NADH may produce 4-6 ATP depending of certain factors. Adicionally, before Acetyl CoA may participate in Krebs cicle, piruvate most be decarboxylated to become in the Acetyl CoA, AND that generates 2NADH, which in ECT will turn in 6 aditional ATP. So, there are the extra ATP.
Glycolisis 2 ATP + 2 NADH (4-6 ATP)
Decarboxylation 2 NADH (6 ATP)
Krebs cicle 2 ATP + 6 NADH (18 ATP)+ 2FADH2 (4 ATP)
Depends on energy requirements so it's not a consistent production. It might vary depending on energy needs.
sir I wanna learn w/w, ppm, ppb ,etc numericals.
I also wants to their theory,
and please send me a link for this
I'm look forward to receiving yours reply
thanks
I watched a Khan Academy video where they said you get 3 NADH but here it says 6? Also, they said you get a total of 38 ATP in the end but you say 28. Why is that?
Khan Academy for Bio is wack. Stick to prof. dave, crash course, and your textbook.
Dude^^3 NADH are produced by EACH pyruvate molecule, since there are 2 of them by 1 glucose molecule
38 ATP is an ideal case
1:56
Mitochondria are the powerhouse of the cell
I am from India and I don't know where do you belong but thanks for explaining
please do physics videos as well
those are coming next! but it'll take a little while, i think they could be up by the end of the year.
waiting desperately , by the way thanks to your videos you saved our mid semester chemistry exams
what about oxygen? where is it from all of that ?
It's the final electron acceptor in the chain.
@@ProfessorDaveExplains thank you, i love your vids and your channel , indeed one of my favourite sciencey TH-cam channels..hope all the best for you
You know you are intelligent!🙉