Orexin/Hypocretin Role In Sleep And Narcolepsy Explained (Sleep Neuroscience) | Originals

Welcome to Science With Tal!
In this video, we will cover some basic sleep physiology, what & where orexin neurons are as well as what function do they mediate. We will also consider some clinical implications of orexin signaling and how it relates to sleep disorders such as narcolepsy and insomnia
To improve the quality of my content, I highly value the feedback from the viewer so do not hesitate to give any feedback in the comment section.
TIMESTAMPS
0:00 Introduction
0:50 Polysomnogram & Hypnogram
2:54 Sleep Circuit In Brain (Wake/Sleep-Promoting)
4:40 Molecular Mechanism Of Orexin
6:00 Orexin Influence On Sleep Circuit
6:51 Orexin & Narcolepsy
8:14 Orexin & Insomnia
9:04 Conclusion
RESOURCES
Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource)
- Eric Kandel: Principles of neural science (6th edition)
- Meir Kryger: Principles and practice of sleep medicine (7th edition)
- Ayumu Inutsuka: The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions
- Timothy Quinnell: Narcolepsy, idiopathic hypersomnolence and related conditions
- Chunmei Wang: The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases
To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.
CREDITS
Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - sunflower ( • lukrembo - sunflower (... )

[@alinedealmeida97]

Super well made video! Thank you :)

[@sciencewithtal]

My pleasure! Thanks for the feedback!

[@rafaelwaa]

Best video about this theme

[@sciencewithtal]

Thank you so much!

[@christiansvane7868]

Great explanation; thanks a lot

[@sciencewithtal]

Thank you!!

[@mohamedhadod2467]

enjoyed the vid

[@sciencewithtal]

Thank you!!

[@akash46464]

Can you help me I'm suffering from medication induced insomnia?

[@sciencewithtal]

Hi, sorry to hear that you have to go through that. I may help you in understanding the mechanism behind the medication you take and your insomnia but I think the best solution would be to discuss this matter with a health professional so you can get the appropriate help.