What Makes Orexin-Blocking Sleep Agents Special?
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- เผยแพร่เมื่อ 12 มิ.ย. 2023
- Belsomra (suvorexant) entered the US sleep-aid market almost a decade ago, and was recently joined by Dayvigo (lemborexant) and Quviviq (daridorexant). All of these agents work to block orexin receptors in the brain, a distinctively different mechanism than other sleeping pills. Despite several distinct advantages over other classes of sleeping agents, sales have not been spectacular. But recent discoveries, particularly a suggestion that suvorexant may reduce the amyloid Beta plaques and Tau fibrillary tangles that are hallmarks of Alzheimer's Dementia has driven up attention. Experts think that these agents may also have a role in treating depression, anxiety and ADHD.
Took my 1st 5mg dose of dayvigo tonight and falling asleep watching your video 😂......seriously thankyou!
Just wait until you view my video on cyclic sighing for sleep! th-cam.com/video/EyX-L1TELfg/w-d-xo.html
My doctor prescribed Belsomra for sleep - it works well as long as I take it three hours after eating - need an empty stomach for it to work - works well - thanks for the info!
Well executed talk. Interesting and relevant. Really helped me gain a primer on the DORA class of drugs. In my opinion I would change not much…it’s much harder to be engaging and teach without the assistance of dreaded PowerPoints so kudos to you Dr Kruse. Thank you!
Thanks for the vote of confidence. Feel free to share with others and check out the other videos in the video and live sections of this channel.
Thank you! Good information!
Very interesting! Thank you!!
It does not work on me. The first night taking 5mg, it leads to vivid dream in the middle of the night. The second night, no sleep was induced two hours after taking Dayvigo. So upset.
I would try to be patient, and if you can, try for a few weeks. Many people are used to being sedated into sleep, and these drugs don't work that way. They are also among the very few sleep agents that appear to work better the longer you take them.
Too long. Make it shorter and you'll increase viewership 10x
Thanks for the feedback.
that might be true about viewership. I benefited from all of it, including the history. Maybe could make shorter video versions and have a link to the longer version if interested.
Second video I've watched of yours; first was dream re-imaging. Both really good.
I work in child psychiatry, wishing I understood neuroscience better. I've been at it for 15 years but I keep forgetting what I knew; when I'm trying to help someone, I feel like I'm trying to guide them through underground caves in the dark, with just a dim glow stick and an old book of stories about caves.
@@beemaningi thanks for sharing your viewpoint. I am thinking of using the take home messages and converting them to aTH-cam shorts, but I have yet to experiment with the separate TH-cam app needed for that.