I'm in nursing school, and this video was so helpful for PathoPharm! You have NO IDEA how much I appreciate the work you put into these vids!! Thank you Dr. Mike
Man, you are just killing it !!! I love your lectures, and they are to the point, clear and life saving. Keep it up. I would like to tell everyone who is here, to keep on watching your videos and I promise they will learn a lot.
I sat looking at textbooks for 2 hours revising for my P+P exam -- this video in 20mins has cleared my mind and I'm understanding it! Life changer and life saver!! Thank you
Brilliant. I have many autoimmune issues, and this break down explains why they are so careful and, sometimes reluctant, in their practice and how to proceed. It's more complicated than I thought.
This was amazing!! You are awesome. I'm studying Pharmacology in nursing school and this breaks everything down and clarifies so much. Looking forward to more!
Jose Colon 1 second ago In nursing school; a very helpful lesson. I like how you start at the beginning of a process and make your way to what we see in practice, thanks.
thanks mate , not only for the amazingly practical and easy to follow contents but also for your talks . the reason I emphasise on it is that many international health workers who try to do the exams only have access to non-Australian videos and speech. Even though, they are very good too , but hearing it from someone within the system is very helpful. thanks again
Awesome presentation, you explain everything so well, I could read a text book over and over and still not absorb this information. Really you make it so much easier to understand well done, love your work.🤩👍
so yesterday I was studying physiology of pain and I got a MASSIVE headache, I took an aspirin and it wasn't helping, and I started thinking about how it was affecting nociceptors and..well everything is clear to me now. I love pharmacology.
James Conlan Great question! Inflammation is like an unexpected guest. It’s okay for a short period of time (actually beneficial), but if it stays around too long it becomes detrimental. Should be regulated by negative feedback, once the stimulus (e.g. cut) is healed it should disappear. When we use NSAIDs to mitigate pain, it only suppresses the prostaglandin based effects of inflammation. Many other chemicals will still be involved.
Thank .you so much for explaining so well and easy this topic which i found very difficult to understand in other lessons or videos. You are an amazing educator
This is great! I'm surprised you didn't talk about the dangerous fluoroquinolone antibiotics, like Cipro and Levaquin. On their own, these antibiotics are well documented to cause irreversible full body damage, but when administered with CORTICOSTEROIDS, they are much more likely to disable the patient. Why didn't you talk about this relationship?
According to Harvard Pharmacy Book, NSAID can also increase the risk of strokes. Does it because it makes the plagues travelling in the vascular system? Yes you have explained in the video, those are cox2 blocker. Thanks
Quick correction: Tylenol (acetaminophen, also called paracetamol) is NOT an NSAID. Mentioned at 11:30. Maybe u were thinking of Aleve (naproxen), which is a common NSAID sold over the counter right alongside ibuprofen. Otherwise, great video! Thanks for this, mate :)
Hi Dr.Mike, lately i was going through an article from American College of Cardiology. In which they have said that combining Misoprostol with NSAIDS can lower risk of heart attack by 44%, 34% lower risk of Renal Injury and 24% lower risk of Stroke. My question is how misoprostol can do that in the absence of prostaglandins?
I took naproxen 1000mg slow release last night and today I feel so tired. I never take medication but thought I'd try... I think I'll stick to my natural anti-inflammatory route.
There are several factors in exercises cure joint pain. One resource I discovered which succeeds in merging these is the Mackyns Nature Guard (check it out on google) it's the most incredible blueprint i've seen. look at all the extraordinary information .
here you are saying that aspirin inhibits both Cox 1 and Cox 2 .. cox 1 increase platelet aggregation and cox 2 decrease platelet aggregation so if its working on both how will this be effective in cardiovascular diseases???
No all ur answers are wrong guys , we give low dose aspirin ( 75 mg ) to prevent platelet aggregation because the low dose aspirin will inhibit only cox 1 and will decrease txa2 production , but in high dose aspirin ( 325-1000) it will inhibit both cox 1 and cox 2 .
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I'm in nursing school, and this video was so helpful for PathoPharm! You have NO IDEA how much I appreciate the work you put into these vids!! Thank you Dr. Mike
I wish my university teachers were as clear as you. Thank you!!
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Man, you are just killing it !!! I love your lectures, and they are to the point, clear and life saving. Keep it up.
I would like to tell everyone who is here, to keep on watching your videos and I promise they will learn a lot.
This is the best explanation I’ve ever had- you really make it sound so simple and intriguing at the same time. Thank you very much indeed.
I sat looking at textbooks for 2 hours revising for my P+P exam -- this video in 20mins has cleared my mind and I'm understanding it! Life changer and life saver!! Thank you
man,seriously i had a big issue to understand NSAIDs clearly , you made it a piece of cake ,,thank you so much
Majid Republic thank you Majid 🙏
Brilliant. I have many autoimmune issues, and this break down explains why they are so careful and, sometimes reluctant, in their practice and how to proceed. It's more complicated than I thought.
Found my new favorite channel for med school. Amazing!
This was amazing!! You are awesome. I'm studying Pharmacology in nursing school and this breaks everything down and clarifies so much. Looking forward to more!
mamasitaaxoxo thank you!! I am so happy that it helps!! Best of luck with exams 🤗
Let's throw all the text books away!!! Just kidding, but you made everything so clear and interesting. I love it so much! Thank you, thank you Dr.!
Jose Colon
1 second ago
In nursing school; a very helpful lesson. I like how you start at the beginning of a process and make your way to what we see in practice, thanks.
only teacher i go to when it comes to pharmacology . thank you very much
This is the best lecture I ever saw in my life regarding NSAIDS! Appreciated!
The most clearly explained NSAIDs vid yet! Cheers!
I am very glad it helped Luke!!
Can prednisone be used for the Coronavirus
Excellent! Thanks for posting. This is such a big help with my pharm class.
This guy is a complete package: teacher, gym endorser and matinee idol. :)
The greatest pharmacological video i've ever seen
Would love more pharmacology and meds videos please!
I'm in high school and understood every single thing. You're a magician.
thanks mate , not only for the amazingly practical and easy to follow contents but also for your talks . the reason I emphasise on it is that many international health workers who try to do the exams only have access to non-Australian videos and speech. Even though, they are very good too , but hearing it from someone within the system is very helpful. thanks again
Thank you this is one of the best videos you have done. Excellent detail and context to help build the full picture
Man he's the best teacher out there and thus channel is the best at that regards
An excellent presentation. You broke NSAIDs down and helped to make sense of the pathway.
the way you break down the information is outstanding. thank you. so much clearer. The subject becomes interesting.
This video is off the chart!! Thank you!!!
Thank you for explaining something that was a bit confusing to me in a very simple and easy to understand way.
Very clear and detailed explanations, thanks so much, please keep doing what you're doing! They help so much
amazingly clear and thorough and your teaching style is superb!
I learned from u than the whole 2 semesters in my collage .. thank u so much
You are amazing! Preparing for my pharmacy licensure examination, big help to review basic pain meds.
Awesome presentation, you explain everything so well, I could read a text book over and over and still not absorb this information. Really you make it so much easier to understand well done, love your work.🤩👍
You guys are amazing!!! Thank you so much for taking the time to help me pass my FNP program :)
so yesterday I was studying physiology of pain and I got a MASSIVE headache, I took an aspirin and it wasn't helping, and I started thinking about how it was affecting nociceptors and..well everything is clear to me now. I love pharmacology.
Haha! That’s great!
thank you so much sir, seriously your way of teaching is great
Very well presented. Thank you so much. Very helpful for a nursing student. You are the best.
legendary explanations as always, thanks guys!
Great work Doc, you make complex stuff look so easy. Thanks
Thank you again for another great lecture! please keep posting more videos 😊
You're literally amazing, thank you for this !
Thank you for the very detailed explanation!
amazing video but I confused on what this means
Prostaglandins Derived from Arachidonic acid via COX1, 2 and 3.
Dude thanks. I didn´t learn pharma that much on my classes and you make it so easy.
What a fantastic presentation! Thank you!
Thank you so much Dr matt I have learnt alot from you than my lectures In school may God bless yo work
Watched 3 videos but none like your lecture. Thanks soo clearr💕
Iv never seen such a high sub rate for the view count on your videos, i think you guys will really take off at some point.
So great at explaining it. Thank you Dr Mike
The best method of making clear.thanks a lot for this. From Indian students
Awesome lecture sir love 💕 from india 🇮🇳
Excellent presentation, Thank you for sharing, very helpful info. 🌼🌺🌸
That was agreat video .well explained.Thank you somuch. looking forward for more lessons
Matt/Mike. Why is it beneficial to reduce inflammation if it is an important protection/repair/regeneration process?
James Conlan Great question! Inflammation is like an unexpected guest. It’s okay for a short period of time (actually beneficial), but if it stays around too long it becomes detrimental.
Should be regulated by negative feedback, once the stimulus (e.g. cut) is healed it should disappear. When we use NSAIDs to mitigate pain, it only suppresses the prostaglandin based effects of inflammation. Many other chemicals will still be involved.
Thank .you so much for explaining so well and easy this topic which i found very difficult to understand in other lessons or videos. You are an amazing educator
Great video! it's nice to learn pharm with clear concepts :)
Thank you!! This really help me understand pharm lecture better and pass my pharm exam
Excellent video, thank you so much!! High quality education for free, you guys are amazing.
UGHHH THANK GOD NURSING STUDENTS HAVE YOUUU ❤️
This is great! I'm surprised you didn't talk about the dangerous fluoroquinolone antibiotics, like Cipro and Levaquin. On their own, these antibiotics are well documented to cause irreversible full body damage, but when administered with CORTICOSTEROIDS, they are much more likely to disable the patient. Why didn't you talk about this relationship?
Hi Andy! Time constraints and this vid was an intro for my students.
Hope all is well!
- Mike
Thanks a lot for breaking it into chunks.
Thanks, you are a wonderful teacher! Very helpful.
Understood the concept, liked and subscribed, turned the notifications on, and also saved the video in my youtube playlist ✅ 👌
it makes sense !!! thank you very much, greating from Africa!
Holy CRAP! I can't believe how much fun that was to learn!!
According to Harvard Pharmacy Book, NSAID can also increase the risk of strokes. Does it because it makes the plagues travelling in the vascular system?
Yes you have explained in the video, those are cox2 blocker. Thanks
Asthma is MIB! 💕 Never looked at it that way.
Nice video. Not an easy topic, but you broke it down quite well.
Thank you! Amazing and helpful explanation :)
Thank. very helpful. find it hard with several concepts but broken down well.
Very helpful explanation!
Thanks !
-A previously confused nursing student ;)
You are a great teacher!
I cannot thank you enough, very easy to understand :)
Just cleared all my concepts....thanks alot Dr. Mike✨
Quick correction: Tylenol (acetaminophen, also called paracetamol) is NOT an NSAID. Mentioned at 11:30. Maybe u were thinking of Aleve (naproxen), which is a common NSAID sold over the counter right alongside ibuprofen.
Otherwise, great video! Thanks for this, mate :)
Gwyn the Gnome that’s correct. I clarify this statement at 15:03 (ie NSAID-like with poor anti-inflammatory properties) and thanks!! 😊
Hi Dr.Mike, lately i was going through an article from American College of Cardiology. In which they have said that combining Misoprostol with NSAIDS can lower risk of heart attack by 44%, 34% lower risk of Renal Injury and 24% lower risk of Stroke. My question is how misoprostol can do that in the absence of prostaglandins?
I am really looking forward for your comments here. Thanks
Great explanation sir... May god bless u always ❤️
Excellent explanations, great charts. Thankyou so much!!
Brilliant, thank you. Incredibly refreshing listening to straight talk. Much easier absorbtion into the intelligence 😄🙏 🙋♀️
Thank you!!! you made it easier for me to understand!
you kill it Mike you are a genius
Broccoli, Brussels sprouts, and many other foods etc have natural aspirin.... So if allergic to aspirin
said be careful what you eat...
Thank you. Helps a lot ! Great explanation
This was so helpful!
excellent explanation sir...
thank you so much.....
Thank you so much, the video was very helpful for me.. and your accent is very clear to me as Arabic girl
Thank you 💞🤙🏻
Briiliant!!!! Concise but so informative.
Brilliant, thank you
You just earned a sub. Thank you so much sir!
Is it right to assume that turmeric and black pepper will have basically the same process as a NSAID?
Great video, easily explained and made me understand things better :)
I took naproxen 1000mg slow release last night and today I feel so tired. I never take medication but thought I'd try... I think I'll stick to my natural anti-inflammatory route.
Brilliant !! Great explanation.
There are several factors in exercises cure joint pain. One resource I discovered which succeeds in merging these is the Mackyns Nature Guard (check it out on google) it's the most incredible blueprint i've seen. look at all the extraordinary information .
Doing BioMedical Sciences,and this topic is giving me pressure... Thank you for the explanation
Thanks! 😊
Holy sh!t mate thank you for helping out a MS1!
elchinio RL glad it helped!!
Can you please explain asthma and the relevance of arachidonic acid, allergic pathway (atopy) and non-allergic pathway
This video was really good. Thanks A lot :)
here you are saying that aspirin inhibits both Cox 1 and Cox 2 .. cox 1 increase platelet aggregation and cox 2 decrease platelet aggregation so if its working on both how will this be effective in cardiovascular diseases???
Aspirin more selective to cox1 activity. It act more upon the thromboxane
Platelet inhibition process is more potent therefore overall effect decreases clotting ability.
actually aspirin irreversibily inhibit cox2 in platelets which means new platelets will be required thus anti-platelets action
No all ur answers are wrong guys , we give low dose aspirin ( 75 mg ) to prevent platelet aggregation because the low dose aspirin will inhibit only cox 1 and will decrease txa2 production , but in high dose aspirin ( 325-1000) it will inhibit both cox 1 and cox 2 .
U are right Ahmad
Thank you for breaking it down 🎉
Complex subject made simple to understand; well structured and penetrating presentation. Well done!
Thank you, Si Dach!
I'm glad you liked it! 🤗
Very helpful. Thank you so much!!
Thank you for clearing things for us