Pain | Pathway and Analgesics (NSAIDs, Opioids, Antidepressants, and Anticonvulsants)

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  • เผยแพร่เมื่อ 28 พ.ค. 2018
  • Everything you need to know about pain! Well, nearly...
    - Pain pathways (spinothalamic) versus fine touch (dorsal column) pathway to the brain.
    - A delta versus C fibres
    - Painful stimuli (mechanical, thermal, chemical)
    - Brown-sequard syndrome (clinical implications)
    - Pain gate theory
    - Endogenous Opioid system (endorphin, enkephalin, dynorphin)
    - Non-steroidal antiinflammatory drugs (NSAIDs) (aspirin, ibuprofen, celecoxib, paracetamol)
    - Opiates (Morphine)
    - Antidepressants (Tricyclics, SSRIs, SNRIs)
    - Anticonvulsants (Gabapentin)
    - And more!!
    Listen to our podcast for more info: podcasts.apple.com/au/podcast...
    Instagram: / channel

ความคิดเห็น • 174

  • @kenfine1469
    @kenfine1469 6 ปีที่แล้ว +162

    This is a Command Performance: It's so incredibly good. I'll be watching this one several times over to get the detail. There should be a TH-cam award for educational videos like this.

    • @DrMattDrMike
      @DrMattDrMike  6 ปีที่แล้ว +15

      Thank you, Ken. That is very kind.

    • @chrishenly9728
      @chrishenly9728 3 ปีที่แล้ว +1

      I think crash course would win lol

    • @marksawatzky8562
      @marksawatzky8562 ปีที่แล้ว

      Yes!! Excellent presentation.😆❤

    • @craigyoung6371
      @craigyoung6371 2 หลายเดือนก่อน

      These dudes are probably full time doctors and/or lecturers, so pretty impressive to get this material up with a proficient explanation, cheers fullas.

  • @kannupoonia7523
    @kannupoonia7523 ปีที่แล้ว +14

    I can’t believe you did this for free ..
    omg what a great lecture.!!
    So well put together.
    Thank you so much.

  • @thebluemonkey100
    @thebluemonkey100 3 ปีที่แล้ว +35

    I watched this video last year when we were talking about pain & painkillers in my second year of MED school. Now, in my third year, we are talking about it again, and this video saved me for the second time. Thank you so much for this, and all your other amazing lectures!

    • @DrMattDrMike
      @DrMattDrMike  3 ปีที่แล้ว +5

      😊 🙏

    • @jukodebu
      @jukodebu 2 ปีที่แล้ว +1

      dont let people suffer because some abuse it.

  • @mezza2920
    @mezza2920 3 ปีที่แล้ว +16

    I was literally having so much anxiety over this topic! Watched the lectures and tutorial, read over lecture notes multiple times, did the readings and it was like a big info jumble and fog in my head! Was feeling really stressed until I found your video. Thank you so much for this!

  • @philipmaxwell669
    @philipmaxwell669 5 ปีที่แล้ว +33

    Thank you Dr Matt. It is a shame that uni lecturers sometimes forget that unless the information is interesting and coherently presented it’s really difficult to absorb or even stay awake.

    • @DrMattDrMike
      @DrMattDrMike  5 ปีที่แล้ว +7

      Very true!!

    • @marksawatzky8562
      @marksawatzky8562 ปีที่แล้ว +2

      @@DrMattDrMike And very easy on the eyes doesn't hurt either!!🎼🎵🎶🌞♨🔊

  • @yachiapatel
    @yachiapatel 2 ปีที่แล้ว +9

    Can't imagine how would I can understand such complicated theories with simple explanations..... All credit goes to Dr. Mike and his team.... Thank-you very much sir for letting us know all such theories with absolute concepts. Your commendable efforts are just speechless.

  • @sadehavvad
    @sadehavvad 6 หลายเดือนก่อน +2

    Fantastic. I've prepared my thesis on pain and was watching to prepare my mind for the thesis defense. I realized my mind was unclear on many small topics until I watched your video. Thank you very much.

  • @sameeds.8270
    @sameeds.8270 4 ปีที่แล้ว +11

    Wow what a lecture! now even a non medical person like me knows what is pain and how we feel pain. More power to you doc. Thanks alot!

  • @ghazalataskeen1618
    @ghazalataskeen1618 4 ปีที่แล้ว +5

    After watching your videos
    I have changed my mind set
    now I want to become a teacher like you
    I have one more thing to say seriously I have no doubts regarding this topic
    Thank you very much

  • @Thefoxesden77
    @Thefoxesden77 4 ปีที่แล้ว +11

    Words cannot describe how grateful I am to you for making this excellent education video! Your deep knowledge and logic explanation is respectable! I am in nursing program and have to do a lot of assignments & textbook reading today; but I feel like watching your video is more important. Thank you so much!

  • @healthscoutptwernergrosse1579
    @healthscoutptwernergrosse1579 ปีที่แล้ว +1

    There seems to be so much intention out there right now to confuse us about the simplest 'things' ongoing in our body ... but THANKS to God we have Dr. Mike to keep it easy and us informed properly 🙏🙏🙏

  • @Nanobot888
    @Nanobot888 ปีที่แล้ว +2

    Wow, this is some genius level explanation right here. They teach us neuroanatomy + pain pathways in dentistry school and it has never made sense together like after watching this video. I cannot capture in words the usefulness of this. Thank you so much.

  • @shreyabhowmik5510
    @shreyabhowmik5510 6 ปีที่แล้ว +26

    Sir, you are an amazing teacher! Your videos are the best in you tube. Thank u soo much for your efforts. Really helpful and life saving!!

    • @howtomedicate
      @howtomedicate 5 ปีที่แล้ว +5

      Yea, I really enjoy them to! They are informative, but also fun to watch!

    • @DrMattDrMike
      @DrMattDrMike  5 ปีที่แล้ว +2

      Thanks!!!

  • @SG333_
    @SG333_ ปีที่แล้ว +1

    Dr Mike I genuinely don't know what we'd do without you. This is such an excellent video, so clearly explained and helpful. Your knowledge and passion for teaching comes across and I wish we had more educators like you! Thank you so much! (You don't know how much you're helping me get through this med degree 😂)

  • @scokim
    @scokim 3 ปีที่แล้ว +1

    Wow - comprehensive and yet simple to understand. Thank you.

  • @daska1410
    @daska1410 ปีที่แล้ว +3

    I am currently studying for pharmacology exams and this video (among your others) has been so helpful. Thank you :-)

  • @mariyazaman5946
    @mariyazaman5946 ปีที่แล้ว +1

    Excellent teaching method. Hatts off to you 👏👏👏 I am Mariya Shah your fan from Pakistan🇵🇰, a BSC Nursing student. You made all topics so easy for me. Lots of prayers and well wishes 👍🏻🤲🏻

  • @shanazporter2417
    @shanazporter2417 3 ปีที่แล้ว +2

    This was an excellent lecture. Thank you sooo much for creating it. You have one of the best channels!

  • @philipmaxwell669
    @philipmaxwell669 5 ปีที่แล้ว +4

    Thank you so much for your videos. The depth and clarity of knowledge presentation is superb

  • @roland.j.ruttledge
    @roland.j.ruttledge 2 ปีที่แล้ว +1

    Excellent, many thanks

  • @phill6159
    @phill6159 3 ปีที่แล้ว +3

    Excellent execution, of detailed information, I learned so much, such an important subject. Thank you.

  • @rachell4576
    @rachell4576 ปีที่แล้ว +1

    Hi Dr. Mike,
    I'm freaking out after two weeks of nursing class because I can't manage all the new knowledge in my assigned textbook. Then I thought, let's seek the issue I don't comprehend on your channel like I did in physiology class. And now I'm watching this video, even though it's been 4 years, but I appreciate your time and effort, which never expired even 20 more years because without your channel my nursing profession would never start.
    Even if the Pain gate theory fooled me the first time I read it in a study guide, I now find it quite enjoyable. Your explanation makes a lot of sense to me, and it makes me want to learn more.
    If you have time, could you correlate "first pass effect, bioavailability, protein binding" with "pharmacokinetics' vs "pharmacodynamic"?
    Thank you so much for this helpful video!

  • @jessicaelliot2031
    @jessicaelliot2031 2 ปีที่แล้ว +1

    You. are. AMAZING!!! REWATCHING X100000000000000 TIMES! THANK YOU!

  • @Kat-zc4lt
    @Kat-zc4lt 4 ปีที่แล้ว +2

    WOW. Very well explained. Thank you!! Will definitely be watching more of your videos.

  • @cristianmurar3185
    @cristianmurar3185 2 ปีที่แล้ว

    Thank you, doctor Matt. You rock! You made my life much easier. I wish I had you as my professor.

  • @howtomedicate
    @howtomedicate 5 ปีที่แล้ว +6

    An other fantastic video! I do not know how you guys keep it up?!

  • @penelopebaba
    @penelopebaba ปีที่แล้ว

    I am so grateful for your videos... My Physiology instructor is so hard to follow, I love physiology now, watching the videos you put out that clarify everything.... So Great!!!!!!!!!

  • @dessertthingy
    @dessertthingy 5 ปีที่แล้ว +2

    This is an awesome explanation, thank you!

  • @rebeccabecca6468
    @rebeccabecca6468 4 ปีที่แล้ว

    Excellent resource for my nurse prescribing pharmacology exam! thank you

  • @zarakaushik2206
    @zarakaushik2206 2 ปีที่แล้ว +2

    This was awesome, you are an amazing teacher and I learnt so much. Please keep making such videos. I am doing my Masters and this really helped me understand pain so easily, rather painlessly.

  • @paulbarron2796
    @paulbarron2796 5 ปีที่แล้ว +3

    wow!!! thank you so much. I have watched my lectures over and over and read and read and in 1 hour you have made it all so clear. I will definitely be watching your other videos. Thank you so very much for taking the time to produce these video's

    • @DrMattDrMike
      @DrMattDrMike  5 ปีที่แล้ว +1

      Paul Barron Thanks for watching, Paul!

  • @taif5570
    @taif5570 5 ปีที่แล้ว +2

    This is amazinnng!!! thank youu so muchhh. keep going the world's best teacher .

  • @dawndomenico1377
    @dawndomenico1377 6 ปีที่แล้ว +2

    Thank you!

  • @sarahabed805
    @sarahabed805 7 หลายเดือนก่อน

    Thank you for the clear explanations 🥲🙏🏻

  • @dynamaraferreira7279
    @dynamaraferreira7279 ปีที่แล้ว

    Fantastic!! I'm so thankful for this amazing class. 👏👏

  • @enlightholisticfitness4996
    @enlightholisticfitness4996 3 ปีที่แล้ว +1

    Dr Matt is a god send!!!

  • @ruditesalina4973
    @ruditesalina4973 3 ปีที่แล้ว +1

    Brilliant!!! Thank you so much!

  • @nicoleverinumbe5838
    @nicoleverinumbe5838 4 หลายเดือนก่อน

    Hello Dr Matt
    It's 2024 and your video has literally saved my life
    Thankyouu

  • @ATINUKE67
    @ATINUKE67 2 หลายเดือนก่อน

    thank you Dr Mike

  • @sophiegroom5285
    @sophiegroom5285 9 หลายเดือนก่อน

    Explained so well!!! Thank you ☺️

  • @m.a6894
    @m.a6894 3 หลายเดือนก่อน

    The way I pay £9000 a yr for education but those idiots can’t even teach close to how u teach. This video was phenomenal. Ur saving me literally

  • @wendelasan7299
    @wendelasan7299 5 ปีที่แล้ว +1

    Amazingly simplified 😊

  • @anut32
    @anut32 4 ปีที่แล้ว +1

    Thanks for such a wonderful video.

  • @drshetewy
    @drshetewy 5 ปีที่แล้ว +2

    Excellent
    Thanks a million 🌹🌹🌹

  • @tha_denzel_lit
    @tha_denzel_lit 2 ปีที่แล้ว +1

    thanks Doc.

  • @kaiwt2133
    @kaiwt2133 2 ปีที่แล้ว +1

    Thank you for this. It helps a lot 👍🏾

  • @gregkass2010
    @gregkass2010 4 ปีที่แล้ว +4

    Literally stubbed my toe watching this video. Really brought everything together -___-

  • @GhanaboyPharmD
    @GhanaboyPharmD 4 ปีที่แล้ว +2

    Man this is the best pain pathway video I have ever seen... thanks!!

  • @dhillonamarsingh5033
    @dhillonamarsingh5033 2 ปีที่แล้ว +2

    Fantastic Explanation Thanks

  • @springsh6678
    @springsh6678 4 ปีที่แล้ว +1

    Thanks alot perfectly done...

  • @dipenshakya2184
    @dipenshakya2184 2 ปีที่แล้ว

    Exceptional work. Your videos always help me to clearly understand the concepts. Thank you for your work

  • @scrub_itoff9849
    @scrub_itoff9849 5 ปีที่แล้ว +4

    This was so helpful 👍🏻👍🏻👍🏻

  • @mohamedabomera5598
    @mohamedabomera5598 3 ปีที่แล้ว +2

    Man you have just saved my life ❤

  • @sarvinozakhadova
    @sarvinozakhadova 4 ปีที่แล้ว +1

    thank you so much for information

  • @emulychan
    @emulychan 5 ปีที่แล้ว +26

    thank you for using a whiteboard and drawing! i'm so sick of powerpoint graphics to explain anatomy

  • @user-xd5jy8mp4q
    @user-xd5jy8mp4q 7 หลายเดือนก่อน

    you made it very clear , thank you doctor you helped me❤❤

  • @buombothmut
    @buombothmut 5 หลายเดือนก่อน

    You're smart Doctor
    Thanks so much

  • @metoo9795
    @metoo9795 3 ปีที่แล้ว

    Thanks you so much I am inspired to keep on learning

  • @lilywhite8123
    @lilywhite8123 ปีที่แล้ว

    Thanks a lot. I appreciate your work. You made me understand more than my lecturer God bless

  • @wonholden3430
    @wonholden3430 ปีที่แล้ว

    The explanation is pretty good, Thank you.💯

  • @sarayounis9776
    @sarayounis9776 3 ปีที่แล้ว +1

    This is so good it has brought me back hope that I can pass med school

  • @adelaredding1594
    @adelaredding1594 4 ปีที่แล้ว

    THank you!!! very nice class!!!

  • @sayaniumanda9076
    @sayaniumanda9076 10 หลายเดือนก่อน

    Thank you so much ❤

  • @cmble1147
    @cmble1147 2 ปีที่แล้ว

    You are amazing!! This is amazing! Really helped me to understand a topic that just made no sense on paper! Thank you so much!!!

  • @amiruladib9760
    @amiruladib9760 3 ปีที่แล้ว +1

    superbly good. easy to understand. TQVM

  • @ravindarbethi8675
    @ravindarbethi8675 ปีที่แล้ว

    One sincere request. Kindly edit the transcript . It has no punctuation marks. Also there are spelling errors (paying is mentioned in place of pain here in this video transcript) that makes one difficult to catch the new terms of technology. All this is probably due to auto-generated text. TH-cam too must develop auto-punctuation, automatic capitalisation, and continuous updating of technical terms and acronyms.
    This is otherwise a “must watch” video about pain. Excellent, and very much informative. Thanks for updating our knowledge. Simply superb.

  • @ramaothman7053
    @ramaothman7053 ปีที่แล้ว

    Thank you Dr

  • @H-Nawafleh
    @H-Nawafleh ปีที่แล้ว

    Very useful content, many thanks 🇯🇴🇯🇴❤

  • @johntom2362
    @johntom2362 6 หลายเดือนก่อน

    Thank you 🙏🏽

  • @summergirl198
    @summergirl198 2 ปีที่แล้ว +1

    Amazing!! Thank you so much!!!

  • @kyriakeka4447
    @kyriakeka4447 3 ปีที่แล้ว +2

    Thank you Dr Matt, amazing video as always. Could you please explain how medications such as Lyrica work in pain management?

  • @pastorbrightamegazo9231
    @pastorbrightamegazo9231 10 หลายเดือนก่อน +1

    Good job!

  • @jenniferlyke9608
    @jenniferlyke9608 11 หลายเดือนก่อน +1

    Thanks!

  • @dinanassar4008
    @dinanassar4008 5 ปีที่แล้ว

    EXcellent lecture thanks a lot

  • @nstats3250
    @nstats3250 10 หลายเดือนก่อน +1

    Great content thank you. Would you consider generating some content regarding the use of Naltrexone for chronic pain treatment? Cheers

  • @fareehaadnanali1019
    @fareehaadnanali1019 2 ปีที่แล้ว +1

    Amazing video!! Thank You

  • @littleshaikh4116
    @littleshaikh4116 3 ปีที่แล้ว

    Love your lectures .big fan.

  • @heatherd8924
    @heatherd8924 3 ปีที่แล้ว

    This has really helped my understanding, thank you! (1st year physio). Need to nail this in my exam

  • @wanfeunloo7066
    @wanfeunloo7066 4 ปีที่แล้ว

    thank you so much !!!!!!!! i love your video. great explanation

  • @user-vdjxbwkskbc
    @user-vdjxbwkskbc 10 หลายเดือนก่อน +1

    really great video, very helpful thank you! but why is there an advert like every 2 minutes or so

  • @andreacave3692
    @andreacave3692 ปีที่แล้ว

    This video is amazing

  • @drastichaudhari
    @drastichaudhari 5 ปีที่แล้ว +1

    SOOOO helpful!!!

  • @rajivanand236
    @rajivanand236 2 ปีที่แล้ว +2

    Awesome lecture bro 👌👍1st time ⏲️ 1 hr I didn't lost my concentration and you have a great future in teaching profession. I wish you all the best and make some more videos 📹 keep continue the videos

  • @soul1315
    @soul1315 5 ปีที่แล้ว +1

    Thank you Thank you Thank you♥️♥️♥️

  • @kulejoseph8766
    @kulejoseph8766 5 ปีที่แล้ว +1

    Good work big man

  • @vaishnaviramakrishna265
    @vaishnaviramakrishna265 4 ปีที่แล้ว +2

    You nailed it Sir! Thank you so much!!!!! :-D

  • @gehadhalawa2697
    @gehadhalawa2697 3 ปีที่แล้ว

    this is very helpful thank you so much

  • @ME-xh5zq
    @ME-xh5zq 4 ปีที่แล้ว

    This is a really condensed topic wow

  • @jennagraham4039
    @jennagraham4039 2 ปีที่แล้ว

    Amazing! Thank you!

    • @Bigbang_Tripz
      @Bigbang_Tripz 2 ปีที่แล้ว

      🔝🔝🔝for all your shrooms, DMT, Lsd, MdmA, ketamine, psilocybin infused bar, wock, ayahuasca xtc and other opioids

  • @emilychiechi4446
    @emilychiechi4446 2 ปีที่แล้ว +1

    Thank you! Much appreciated :)

    • @Bigbang_Tripz
      @Bigbang_Tripz 2 ปีที่แล้ว

      🔝🔝🔝for all your shrooms, DMT, Lsd,MdmA, ketamine, psilocybin infused bar, wock, ayahuasca, xtc, psychedelics and opioids.

  • @sarayounis9776
    @sarayounis9776 3 ปีที่แล้ว +1

    Thank you so much sir you are amazing

  • @FatemePishgooei
    @FatemePishgooei 2 หลายเดือนก่อน

    Thanks a lot❤❤❤❤❤❤

  • @jessicacorley
    @jessicacorley 3 ปีที่แล้ว +1

    Thank you for this!! I am set to conquer my exam

  • @01-sudershanapauldrjanmenj4
    @01-sudershanapauldrjanmenj4 ปีที่แล้ว

    Great work sir

  • @thespeechmasterali2499
    @thespeechmasterali2499 3 ปีที่แล้ว +2

    Love u mike

  • @TheBeatjunkee
    @TheBeatjunkee 2 ปีที่แล้ว +1

    Thank you for this incredibly informative video. I was searching the internet on why when I stopped my SSRI that I have been on for 18 years I had an exponential increase in my back pain. I finally made the connection to the SSRI after months of suffering, and I am now back on it for only 3 days, and my pain seems to be under control again. I guess I am now an SSRI lifer even tho I no longer need it for what it was originally perscribed for.

    • @Bigbang_Tripz
      @Bigbang_Tripz 2 ปีที่แล้ว

      🔝🔝🔝for all your shrooms, DMT, Lsd,MdmA, ketamine, psilocybin infused bar, wock, ayahuasca, xtc and other opioids

    • @p.kallas6692
      @p.kallas6692 6 หลายเดือนก่อน

      What did the ssri effect the pain? I have oxicodon for nervpirrande and when I raised the amount ssri the oxicodon stopped work the same. What ssri do you use?

  • @chavviattri7204
    @chavviattri7204 4 ปีที่แล้ว +2

    Thanks sir 😊

  • @sineadohara4085
    @sineadohara4085 3 ปีที่แล้ว

    Brilliant! So well explained and for the first time I now understand why opioids don’t work for neuropathic pain 👍

  • @marksawatzky8562
    @marksawatzky8562 ปีที่แล้ว

    Fascinating!!😆😆 Just subscribed from Canada.👍👊✌

  • @Oscarr312
    @Oscarr312 5 ปีที่แล้ว +1

    Thank youuu