Epigenetics and Aging: The effects of DNA breakage and repair
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- เผยแพร่เมื่อ 11 ม.ค. 2023
- A 13-year international study in mice demonstrates that loss of epigenetic information, which influences how DNA is organized and regulated, can drive aging independently of changes to the genetic code itself. It also shows that restoring the integrity of the epigenome reverses age-related symptoms.
Version that includes an audio-description: • Epigenetics and Aging ...
Learn more at hms.harvard.edu/news/loss-epi...
I'm in my mid 50s and I hope in my lifetime we can reverse ageing.
Aminnn
We will make it I promise you sir
@@user-iv7ny9he9d I hope so. My parents are younger than Dr. Sinclair is so him believing he'll do it in his lifetime makes me hopeful my parents will be around for a lot longer than I initially thought.
@@user-iv7ny9he9dcan I change how I look then? Like my eyes lips face shape butt etc and look younger?
You should still enjoy every second of your life though sir, realistically it's unlikely to happen (and even unlikelier to be affordable). It might not be a healthy attitude to hope for a prolonged lifespan, as we should all be grateful for what we have
Still lots of work to be done. Epigenetic age reversal in mice was done a couple of weeks ago and the mice lived 9% longer than the control. Rapamycin gets mice to live 30%+ longer. This epigenetic reversal was only done once though. The trick is there are 200 different cell types in the body - some types of cells 'age' faster than the other. The liver for example regenerates quickly so if you give the same factor to a liver cell as a brain cell, the liver cell would be rejuvenated too much and become a cancerous tumor. In addition, just because you're say 50 years old doesn't meet all of your cells are 50. The age of your individual cells follow some distribution such that if you give them all the same factor the old cells get rejuvenated and the young cells get cancerous. So in theory age reversal is possible but I think we're one breakthrough away. How can you identify at what stage of the cell cycle each cell is and only target certain cells at certain stages - that my TH-cam friends will be the end of aging.
You raise genuine concerns; I wonder if quantum computers will solve these problems within the next few decades?
If we only knew the exosomic code then we could put the substance into a lyposome and be much more specific. Also couldn't we try to add PARP inhibitors to the drug as to minimize the chance of developing a tumor?
Won't be long now.
If we just ditch industrial seed oil, we could live another 10-20 years longer, plus less DNA damage along the way. There are many ways to skin the cat, some are way cheaper.
Diet plays a huge factor in this as well. If you eat things that cause genes damage then there's no use on trying. A vegan diet is optimal on genetic repair be it that plants have antioxidants which stops aging on it's own.
Thank you Dr. Sinclair to you and your group for dedicating your life to studying this arduous work.
Hopefully his company's petitioning the FDA to pull NMN off the US market doesn't get approved. Given NMN has been sold as a supplement for years before Sinclair's studies began, if only his company is allowed to monopolize the sale NMN it will very likely mean a large jump in the costs for the average consumer. Its not good to deify people or put them on pedestals or refuse to see their flaws. Watch as this comment gets deleted or shadow blocked.
@@2drealms196 Yeah this guy went from doing cool things to becoming a money greedy cunt, to say it bluntly.
Arduous? I would think rather exciting myself.
It’s coming. I can’t wait for us to finally stay looking good our whole lives. I hate how old age disfigures your body and makes it impossible to date when you’re older
lmao dating is ur worry ??
@@gurugamer8632 great for you
@@gurugamer8632 yeah no 74 year old is using that ID and commenting here
@@liamkneeson he didn’t show ID he just commented
@@SpringChickensOnlyMan userid ? its not that deep
Thanks for sharing this info so freely Harvard - optimism through science!! Disregard at your own folly PLEASE keep posting and keep the love of learning alive 🙏
Thank you for explaining this complicated topic in a way that people with only basic biology education can understand.
wow, amazing work. Asides from aging, just in terms of chromatin remodeling and PIC-recycling, paradigm shifting.
That video was surprisingly well made
thanks for the amazing work and groundbreaking study about the meaning of life.
@J Bond
The meaning of life is living it.
Thank you for explaining such a difficult research in an accessible language. Love you, HMS 🤍
Wonderful news! Thank you so much for your amazing work 👏🏼👏🏼👏🏼
How a privilege to live in the 21st century !
But now with this video I'm waiting for the privilege to live in the 22nd tho 😅👀
@@keynadabyand from there on lol
This only works so long as the infrastructure remains in place, many factors put perpetual anti aging at risk. Regulatory, civilizational collapse, ect... I could see the government forcing people to die to keep population numbers under control: a less invasion strategy would be removing social security for those who choose to live forever; idiots who are really bad at math will protest this, but people who think and understand compounded interest would take the deal. They also could limit everyone to one child households, assuming every mom has one child this would invert our population to roughly double its current, assuming zero deaths of accident which would also still occur.
More privilege to live in 22st century.
Not really, as humans are still so primitive and barbaric. But they sure do love to congratulate themselves on being so brilliant. Ugh.
Both mice are adorable
They were both sacrificed in the advancing March to make humans live longer.
Deserves more views…
David Sinclair looks good for his age.
omg this is amazing AMAZIIIIIIIING
Love it.
Very nice, perhaps my kids will love longer and healthier lives.
The sound effect of DNA “loosing” was VERY disturbing
Time to find out how to donate to these companies who are going to run with this
I, for one, am glad they animated the tldr for me
Pls do it quickly before I turned 40. Life is good here.
😂
Good stuff David! Keep going with it all, hopefully you can put things like PKD (kidney diaease) , and othera into the hiatory books.
I would never be able to learn all the things I want to within the normal life span of the average person and as we get older the harder it for us to learn, hopefully this can help us all.
I don't find it gets that much harder
I find it harder to invest the time in specific areas because there is just so much to learn
I don't have enough time to investigate fully a topic of interest
There’s a video from wired here on TH-cam that debunks that idea that it’s harder to learn as we age, in certain areas it’s exact opposite.
@@ars571 sounds like BS
I know right. There are times that I feel so sad I won’t be able to devote more time in the topics that interest mes So, if we were to ever get to live to a thousand or so, i’m going to have plenty of time to do what I want.
@@stultuses no it definitely gets harder as neuroplasticity declines
I love how everyone in the comments is an expert on this stuff. Thanks for all the hard work doc now hurry up and keep me young forever so I can create my familial army
Dr Pius Ozigbe is Always on time. compassionate. Empathetic. easy to take to and relates exceptionally well. Hands down the most effective and efficient doctor I recommend him. thank you doctor!!!!!
Good stuff David! Keep going with it all, hopefully you can put things like PKD (kidney diaease) , and others, into the history books.
Give it to us NOW... We had no problem taking part in the mRNA Experiment.
Morrrrron
Eu realmente curti seu canal. Obrigado pelo trabalho que você dedica em seu canal!!
Eu também tenho temas relacionados à saúde. Efetivamente, eu sou especialista em telemedicina, prestando assistência em todas as regiões do Brasil.
Continue postando!
What's that part about reversing BLINDNESS??
Wow Amazing.!
Has anyone tried this on normal aged mice and was the imbalance from transcriptional stress from DNA lesions favoring short proteins present.
Ding ding ding!
They didn't because it probably wouldn't work, progeria is a well known disease that only look like aging but isn't, the dna is still normal age its just filled with crap that interfere with its normal work. If you remove the crap the cell will work normally for its age.
its not reversing agin, just curing progeria
I wish you good luck and success in your future research.
Can stem cells assist in the de-aging process somehow? Im assuming if these proteins/cells are "Getting Tired", can we recruit new stem cells, program them to the specific organ we want to target and send them in to produce "New Born" proteins/cells that will continue producing DNA accurate cells? I know that there are amazing studies and discoveries involving stemcells... is there anything we can do to reverse aging using a combination of epigenetic reprogramming and stem cell therapy?
Please also see the Flaws and Human Harms of Animal Experimentation
This is a new divide to the science of anti aging
Interesting how anti-aging is essentially negative entropy, and nucleic acids being informational units of the cell, you need to maintain high informational capacity.
Nice video and content
Good science does not only come from accredited "schools." It can come from any individual practicing the scientific method.
If this has been so successful on animal testing as I have been reading, why aren't we offering such treatments to our pets now whilst we work on making it work on humans?
right now they are in clinical trials, but I'm sure you'll get it soon!
Look up Christ within, if you want a doctor's opinion, cerebrospinal fluid and the fluid nature of consciousness video on yt
They've been able to speed up aging. The older looking mouse had aging sped up. They have not yet slowed aging. Heck, at the rate of discovery, maybe they have and we just don't know yet.
Rat model are not 1:1 on human models. So oftenly we need a middle stage that prevent detrimental effects to humans. Like cellular tissue. The problem with this is that funding is being pushed back.
@@dherman0001 they have slowed aging, you dont know anything. Theyve made live mice live twice as long with one genetic treatment recently
I hope gene therapy can allow scar tissue removal so healthy tissue can replace it retina, heart, brain, liver, etc.
I hope so, that way you could also get a step closer to lab build transplantable organs.
So they aged the mouse that is grey, they didn't reverse age of the other mouse. What this did tell me is that they are able to make it so you could be born with the ability to age you, or reverse age you.....I wonder what they could do with that? What would you do in order to be reverse aged?....or keep them from aging you?
How can I help my 72 year old father with this technique.
You've found immortality and only a few million people know about it. This discovery is beyond incredible. I'm proud to live in the same era as you. I kiss your hands. I'm in tears. Thanks a million❤
So how much longer do I have to live for the anti-aging drug to be approved and will my insurance cover it?
I wonder if this can do anything for cancer.
For some cancers, it certainly can. Epigenetic dysregulation can induce carcinogenesis. This should become another effective tool in the toolbox for cancer treatment eventually.
Sir may you help me that what should I study to take part in the reverse aging research can I get your contact sir please help me sir I want to research on reverse aging it's my goal sir please guide me to what I should study
Where the pills sold
I saw another one with this guy talking about the same mice he said that they reversed the aging in the younger looking 1. But in this when he said they sped up aging in the older 1. So which is it?
Two different studies
@@ImKaboose it was the same mice
Amazing work but the aging of cellos is always different . Brain cells and liver cells take paths are different , so a 50 year old could have. Very health liver cells. How would that be regulated .
I volunteer to be an experiment 🙋🏻♀️
(On Monday of January 30, 2023). On the Matter of PhD David Sinclair's Ideation of Epigenetic Ageometry (Epigenetic Dysregulation, or, My Personal Touch, Entropy at both the Genetic and Epigenetic Levels). A Phenotype of Frailty Syndrome (FS) is hardly disintergratable form the Genetic and Epigenetic Mechanisms as much as Function is a Direct Correlation to Structure. Malnutrition seems to be herein Common to all Phenotypes in the Matter of Geriatrics, for which I indicate naturally an Increase in Protein(s), Amino Acids, along with Standard Vitamination And Minerals (Essential Nutrients if not Biological Molecules of Trace Proportions); and only indicate Caloric Restriction (Anorexia is a common Cause of Malnutrition along with other Factors) when Diet is Questionable (As in Pesticide ridden foodstuff). And, this genuinely seems to be the parameters influencing the Mice Studies also; The Aged Homologue (altered mouse) might have been Epigenetically Altered but notwithstanding the Diet Cofactor is a Plausible source of more rapid Aging while the non-Aged one is rather less phenotypically manifested. However, determining length of Lifespan on wholly on Epigenetic Chronometry and Aetiologic Agent of Ageing is an Overstretching of Molecular Mechanism(s) therein. I have delved in the Matter of Epigenetics slightly but could not negate the Genetic Disarray (Both Genomic and Gene Expression [Transcription/Translation Axis]) in a Homeostatic Dysregulated and Sarcopenic Subject as much as I would attribute Healthy attributes to mice on the same terms as to Man (even if such an Experimental Human Could Exist). While Genomic And Genetics are a Thriving and Flourishing Enterprise (Certainly More than as A Science), the Standard of Care (SOC) should still include Basic and Fundamental Essentials (Geriatric Comorbidities of Dehydration and Malnourishment should not be Relevant in a "Well-Developed, Industrial Society") and Therapeutics therein should still be under such traditional Methods because the best part of our Failures as a society are in Common Sense--Preventable--Factors based (Cardiovascular Disease, Metabolic Syndrome(s), Stroke etcetera) and less having to do with inherited Disease of a Genetic Basis (Even though such are not yet proven but associated with Genetic Regions only). Perhaps, one day there will be such Sophistication of Technology and Understanding; but, to forsake the Standard of Care (Conventional Science Basis) for a Speculative (Most theoretical) therapeutics, is sheer Malpractice. Heil!
Let's live better lives
Are Chromatins addressable?
Wow 🤩
I thought the story of the mice had to do with NMN... was that not the claim in earlier iterations of how one mouse was older and one younger? Or am I encountering another Mandela effect?
Two different studies
@@ImKaboose can you give me a hand looking for where the other one is published? 😅
Dr.Bruce Lipton said this in like the 70s
oh my that sound effect gives me agony.
other than that, lovely video
DNA gap is the best solution to epigenetic aging.
OK, you can now accelerate ageing. But how far on going the other way are you? The next step is preventing it, then reversing it. This will most likely be more difficult than accelerating it. For reversing it, the genes that should be turned off should be turned off and those that should be turned on should be turned on. I suspect that's easier said than done. Bummer.
And I wonder what the effect on life expectancy will be.
It's not as difficult as one might think. We already have genetic engineering techniques which alter DNA sequences using things like CRISPR-Cas9. Inducing epigenetic change is just as feasible - you just need to target the right region of DNA with enzymes that make epigenetic changes. Histone deacetylases, methyltransferases.... the various chemical modifications to histones are well-documented. Maybe some specific epigenetic analogue of CRISPR could be developed.
The larger hurdle than being ABLE to do it is knowing WHICH genes to turn on or off. We don't yet have such a masterful understanding of genetics that we're able to know the "recipe" for altering gene expression that will "rejuvenate" cells. It's complicated since so many genes have so many interrelated effects and functions. But I believe epigenetics will surely prove a promising clinical frontier to explore. Epigenetic changes can be just as impactful to an organism's health as outright mutations, if gene dysregulation is severe enough.
@@Synathidy You're right. I later wondered if ageing is produced by always the same offending genes being on or off. If it is, a generic treatment, turning set A on and set B off, will do the trick. But will this only stop further ageing or reverse it?
The Fusion of Longevity.
when you think of the protein machinery as actual machinery, its reasonable to apply the wear and tear principle
When you accelerate the anabolism of proteins and the machinery is cranked, you are accelerating aging because the machinery is slowly getting wore down like with high calorie diets and spiking mTOR all the time, or some growth factors
Err, so how is the reversal even done? It seems like it's much easier to enhance aging (cutting DNA) than slowing it down.
Can you add me to your list to have the first injection to prolong my life 🧬
So from the System Administrators' perspective, seems aging is a configuration drift issue.
So what happens when you reverse the aging beyond age 0
Intersting work. I couldnt help wanting to free the lab mice. Always been my issue with biology. Let them retire and taste freedom at some point.
in sya allah aminnn ya allah
This is an amazing research, Honestly I’m so glad to know someone is working on this, incredible i must say. I am also using curcumin capsules from planet ayurveda for it
Is it like nmn?
If they want human guinea pigs, I'm up for it.
Clue. Aging is in the circulatory system mostly the lymph.
What makes you say that?
@@hansomekim1219 This is preamble. Tip of the iceberg. On cellular level a simple explanation will not do. It needs state of the art labs to probe the circulatory system and the residue that with passage of time overwhelm the 'return' system and thus the aging markers
@easterjateru7801 why cant blood overwhelm the return system just as well as the lymph? Theres more blood than lymph
My social media credit score is screwed.
So where is the human version? I need it fast for my parents.
ILL PARTICIPATE IN YOUR STUDY LOL
This is the way I see it, if you're lucky, you have about 75 years to live and a eternity to be dead. What's the friggin rush to shuffle off this mortal plane? If modern medicine can make me live 2-500 years, I'm all in! Over 100 years ago, the average lifespan of a man was 50 if he was lucky. A fair majority of us surpass that every day. Let's go for it. I gotta see this.
At least all people who fight aging and death in their way,be it advocating,research,funding etc...we would have gave a fight for this goal even if we fail in our mission.
Only by trying we could succeed.
We won't go down the cliff like the ones who are in denial or are naive in some fairy tales who for sure can comfort but in no way stop the suffering of old age and the bleeding in seeing our grandparents and our parents die.
To me it is unbelievable that whole humanity is not involved in this in some way. This is way to important to do and life would be so much better for all if there is more involvement to gain control over aging. How is it that only small percentage of people are trying to find the solution for worse f thing that can happen to people ? LET'S ALL INVOLVE using internet for connection, AI for help analyze data and cure this shit already !!!!
Because you need sufficcient knowledge and "a pure heart" to do research in this area.
Lets say 1/3 of the human pouolation is fighting for survival, (they cant even think about old age) 1/3 doesnt give a shit on anything because they lack the intelectual tendency to think about certain things and 1/3 is greedy and has lots of money so they dont care how long their live ist only how good it is right now.
There you have your answer :)
We can slow again and live until we are 700!
The government: New retirement age is 675.
Should we start celebrating Lamarck Day? See ya August 1.
If they get this process right, we'll all be able to work until we're 150 yrs old. Won't that be fun.
Thats if you dont lose your job to ai first
yes, it is much more fun to get sick and die
Any work being done on how NMN might rejuvinate female fertility as yet? A lot of women are now taking NMN in the hope that it can impact human ovaries in the same way it helped those elderly mice that had healthy live births. I hope us females don't get forgotten about, as is so often the case with medical studies. Being able to rejuvenate fertility for women who have had fertility struggles will be pretty major worldwide. I just hope NMN doesn't become prescription only as it will mean UK women won't be able to access it so readily, if at all.
The problem of menopause is a little different from the question of physiological aging, since the former comes from the exhaustion of oocytes, which are "manufactured" by the oogonia during the embryonic period of the woman, and is finite, not from changes in the genetic and epigenetic machinery and subsequent "inflammaging" of the tissues. We are not mice or rats... We, humans, have a different breeding strategy, and we still don't know how to reverse the production arrest process, although according to some authors there is some histochemical and histological evidence of oocyte production in female adulthood, albeit, I think, in a residual way. But the ingestion of NMN, together with the use of senolytic molecules and antioxidants, if by itself it cannot reverse the process of menopause, it may eventually improve the efficiency of oocyte recruitment during reproductive cycles and, who knows, prolong the period of female fertile life...
This could also cause many women to procrastinate on the issue another 500 years.
@@victorcarlostorresdealmeid5535 thanks for your detailed reply, and I hear what your saying. The concept of running out of eggs isn't news to women. What I'm interested in is that we have many eggs left at the point of menopause, it's just that the remaining eggs aren't healthy enough to conceive. Women the world over have been told by fertility 'specialists' that they've run out of eggs, only to rejuvenate those eggs with supplements and lifestyle factors like fasting etc. That said I get that those protocols will only go so far and that eggs can't be rejuvenated indefinitely. My focus is on those redundant eggs that still have a chance of becoming healthy. But I'm not holding my breath as sadly men tend to centre men first when it comes to science. Even the mouse fertility discovery seems to have been accidental.
@@baigandinel7956 what procrastination are you referring to exactly?
@@ConnieWobbles Fertility is an easy answer for most women. If you want offspring... do it while you're still young and fertile. If you wait...there are consequences for that action.
Got something to help mom?
I winder if i will still het to benefit from this and if private for profit inustry will get its dirty pawns on this.
😢
Imagine if you could be 25 forever.
Bro i'mma be 25 in January, these guys better hurry up
🙌🙌🙌🙌🙌🙌
Does the covid mRNA vaccines age you too?
just waiting for the Zombie Apocalypse.
A superintelligent computer could figure all this out in a decade.
It might sound crazy, but so did ChatGPT six months ago.
It's like you're bubbling on a tiny tiny scale
If this gonna be successful, can they apply this to humans as soon as possible??
i wish that became vaccine to all people in the world
I just cook a mice and eating it so I stayed youthful 😅
Tissue regenerative if human succsesfuly made, then how will look like the future people male to female
Take chances, roll the dice, screw laws, cure aging by any means necessary, act like God, well done work
I think, once it's ready and made affordable for the public, euthanasia should also be made legal. Even if it's past an age bracket.
I like the thought of getting old without the pain, wrinkles and grey hair. But I wouldn't want to live forever.
I can also imagine the population issues if everyone started living twice as long at least.
Eventually, they're going to get this figured out, but how will the mind cope with a thousand years of information.
nice, the elite will be immortal soon
Funny how people think something like this will be available for everyone. Some people can't even afford diabetes medication or effective cancer treatment. And many can't even afford food or shelter.
The smart will live longer and healthier lives. The grumpy contrarians will die and no one will miss them.
@@ElGatoMarcus A future society of 'smart', long-lived sociopaths, eh?
@@ElGatoMarcus natural selection at its finest
I wish we had a solution to the ageing process right now. I've just turned 50 and I'm not liking this at all.
Excellent research, but all I'm thinking about is that poor mouse. :c
What about the chicken ,beef , lamb ,shrimp , frog (frog legs if that's your thing ) , escargot , eggs from incarcerated hens ?
I would crush the legs of hundreds of very cute little puppies and pull them off with a vice before i bite their necks and cut their arteries while still alive and suffering if that could save 1 child from a deadly disease.
AI and quantum computers “ Enter the chat “😮