Hi there! Commenting again after listening to the episode again. I think there’s a lot of cool data in this episode such as the Japanese study (around minute 19) that compared the use of a 2.5% BPO in three groups: 1) with an anti-acne medicine (clyndomycin?), 2) with adapalene, and 3) no BPO, just the anti-acne medicine (can’t spell) and adapalene. It was neat to look at the graphs of how each of the three groups did over the 12 week (?) period. Actually surprised about how it appeared like the group B (BPO and adapalene) outperformed the group C (anti acne medication and adapalene) when it came to non-inflammatory lesions. That means blackheads doesn’t it? I’m not real familiar with the anti-acne medication I can’t spell. But it appears that perhaps BPO does have some efficacy against non inflammatory lesions. How did the Japanese study define non inflammatory lesions by the way? I wish that the Japanese study put the data of what each group was testing in their graph notes. It was a bit difficult to keep the data in mind. If possible, I think it would help comprehension to list out in screen text such things as variables in test groups. Perhaps for podcast listeners it would help to summarize in simpler terms such as “BPO and two variables, no BPO control.” When the three groups entered the maintenance phase of 5 inflammatory lesions or less, I think it’s interesting that they went with the BPO or the adapalene, but did not prescribe the third anti acne medication they tested. Why was that? I think it’s interesting that the 2.5% BPO performed to a similar degree as adapalene when it came to reducing lesions. I have thought of these as pretty different medications. But the study shows similar results doesnt it? At least when it comes to acne. Would you agree that the Japanese study shows that 2.5% BPO and 0.1% adapalene (?) are equally effective against acne? Or is that only after a 12 week period and having entered a maintenance phase, given that it’s generally said adapalene takes about three months (12 weeks) to kick in Is there enough evidence to say one works more quickly than the other? I’ll take a look at the graphs again. Really is a nice visual. If possible I recommend a blog post with the graphs. I am not sure how the fair use policy works though.
Hello, I’m interested in reading the studies in this video. Are these behind paywalls? It sounds like the Japanese study impressed you both with how thoughtful it was. I can rewind back to type the name of the study in the search bar. But just wondering if there are any citation pages upcoming? I understand if it’s inconvenient. I have some various questions but I think I’ll have to listen back as I didn’t catch a lot. But here’s one: Should I be using benzoyl peroxide as a preventative measure before getting acne? Or is it the type of product that’s best used only once a pimple can be seen popping up? Is adapalene better positioned as a maintenance product for the acne prone who want to prevent acne before it occurs? Thinking back to the salicylic acid episode, it sounds as though salicylic acid is not considered an acne heavy hitter in the way BPO is. But what about for blackheads? Is that an area where salicylic acid shines, and BPO does not?
Most of these studies are behind a paywall unfortunately... we're lucky that we can access them through Gloria's alma mater 1. BPO can work in a preventative capacity. There are also studies that show BPO can help prevent scar formation/recovery post acne. So it's definitely a good one to keep in your routine always 2.Adapalene is a great preventative product - there's nothing wrong with having both in your routine if your skin can tolerate well. If your skin is in maintanence phase and you want to keep your routine simple, adapalene is probably the more well rounded option to have 3. Hmm blackheads usually aren't studied independently from acne per se. Anecdotally though ( I have a ton of blackheads), sal acid is the better choice for me for blackheads as a spot treat to clear it fast
@@ChemistConfessions leave on product all over or a benzoyl peroxide wash as a preventative measure sometimes. When studies are done do they tend to favor benzoyl peroxide as all over use or as spot treatments? Did the studies you looked into have any preference about the mode of benzoyl peroxide as a product? Asking but the reality is I really fear bleaching my clothes. Otherwise I would be totally using benzoyl peroxide without hesitation. I have never really found a satisfactory solution. Have you guys gone over ways to mitigate benzoyl peroxide bleach side effects? Do you guys also have a guide for dealing with stubborn blackheads? I haven’t had a clear nose in ages despite continued 2% salicylic acid leave on exfoliant use. Though it helps.
Have you covered melatonin in skincare? What's the deal with melatonin products almost always having lavender oil/extract in them? Also, what about birch sap in skincare?
I am old (65) and get the occasional breakout if I didn't use BPO occasionally. I think I NEED it once or twice a month but that doesn't fit into my weekly regime so I try at least one a week. But, BPO, linens, clothing...sigh. So, my new plan is to wash with a micronized BPO wash in the morning at least once a week. Hopefully that will take care of the occasional breakout without bleaching my lovely linens.
One thing I remember reading is that there's a pretty meaningful difference between how long 2.5% and 5% BPO needs to be left on, I don't remember the specifics, but while 5% does a lot within a minute, 2.5% takes more along the lines of 15 minutes to do the same thing, or something like that... Of course I read that with my tiny layperson brain so maybe I got it all wrong. Also, I'm curious about micronized BPO, it's not available where I live, am I missing out?
Very timely episode!
Hi there! Commenting again after listening to the episode again. I think there’s a lot of cool data in this episode such as the Japanese study (around minute 19) that compared the use of a 2.5% BPO in three groups: 1) with an anti-acne medicine (clyndomycin?), 2) with adapalene, and 3) no BPO, just the anti-acne medicine (can’t spell) and adapalene.
It was neat to look at the graphs of how each of the three groups did over the 12 week (?) period. Actually surprised about how it appeared like the group B (BPO and adapalene) outperformed the group C (anti acne medication and adapalene) when it came to non-inflammatory lesions. That means blackheads doesn’t it?
I’m not real familiar with the anti-acne medication I can’t spell. But it appears that perhaps BPO does have some efficacy against non inflammatory lesions. How did the Japanese study define non inflammatory lesions by the way?
I wish that the Japanese study put the data of what each group was testing in their graph notes. It was a bit difficult to keep the data in mind. If possible, I think it would help comprehension to list out in screen text such things as variables in test groups. Perhaps for podcast listeners it would help to summarize in simpler terms such as “BPO and two variables, no BPO control.”
When the three groups entered the maintenance phase of 5 inflammatory lesions or less, I think it’s interesting that they went with the BPO or the adapalene, but did not prescribe the third anti acne medication they tested. Why was that?
I think it’s interesting that the 2.5% BPO performed to a similar degree as adapalene when it came to reducing lesions. I have thought of these as pretty different medications. But the study shows similar results doesnt it? At least when it comes to acne.
Would you agree that the Japanese study shows that 2.5% BPO and 0.1% adapalene (?) are equally effective against acne? Or is that only after a 12 week period and having entered a maintenance phase, given that it’s generally said adapalene takes about three months (12 weeks) to kick in
Is there enough evidence to say one works more quickly than the other? I’ll take a look at the graphs again. Really is a nice visual. If possible I recommend a blog post with the graphs. I am not sure how the fair use policy works though.
I loved Epi-duo as my gateway drug to Adapalene and BPO!
Hello, I’m interested in reading the studies in this video. Are these behind paywalls? It sounds like the Japanese study impressed you both with how thoughtful it was. I can rewind back to type the name of the study in the search bar. But just wondering if there are any citation pages upcoming? I understand if it’s inconvenient.
I have some various questions but I think I’ll have to listen back as I didn’t catch a lot. But here’s one:
Should I be using benzoyl peroxide as a preventative measure before getting acne? Or is it the type of product that’s best used only once a pimple can be seen popping up?
Is adapalene better positioned as a maintenance product for the acne prone who want to prevent acne before it occurs?
Thinking back to the salicylic acid episode, it sounds as though salicylic acid is not considered an acne heavy hitter in the way BPO is. But what about for blackheads? Is that an area where salicylic acid shines, and BPO does not?
Most of these studies are behind a paywall unfortunately... we're lucky that we can access them through Gloria's alma mater
1. BPO can work in a preventative capacity. There are also studies that show BPO can help prevent scar formation/recovery post acne. So it's definitely a good one to keep in your routine always
2.Adapalene is a great preventative product - there's nothing wrong with having both in your routine if your skin can tolerate well. If your skin is in maintanence phase and you want to keep your routine simple, adapalene is probably the more well rounded option to have
3. Hmm blackheads usually aren't studied independently from acne per se. Anecdotally though ( I have a ton of blackheads), sal acid is the better choice for me for blackheads as a spot treat to clear it fast
@@ChemistConfessions leave on product all over or a benzoyl peroxide wash as a preventative measure sometimes. When studies are done do they tend to favor benzoyl peroxide as all over use or as spot treatments? Did the studies you looked into have any preference about the mode of benzoyl peroxide as a product?
Asking but the reality is I really fear bleaching my clothes. Otherwise I would be totally using benzoyl peroxide without hesitation. I have never really found a satisfactory solution. Have you guys gone over ways to mitigate benzoyl peroxide bleach side effects?
Do you guys also have a guide for dealing with stubborn blackheads? I haven’t had a clear nose in ages despite continued 2% salicylic acid leave on exfoliant use. Though it helps.
Have you covered melatonin in skincare? What's the deal with melatonin products almost always having lavender oil/extract in them? Also, what about birch sap in skincare?
we haven't talked about melatonin yet! But it's already on our list, we'll touch on that soon(ish)
I am old (65) and get the occasional breakout if I didn't use BPO occasionally. I think I NEED it once or twice a month but that doesn't fit into my weekly regime so I try at least one a week. But, BPO, linens, clothing...sigh. So, my new plan is to wash with a micronized BPO wash in the morning at least once a week. Hopefully that will take care of the occasional breakout without bleaching my lovely linens.
A wash is definitely a good option to save the linen!
One thing I remember reading is that there's a pretty meaningful difference between how long 2.5% and 5% BPO needs to be left on, I don't remember the specifics, but while 5% does a lot within a minute, 2.5% takes more along the lines of 15 minutes to do the same thing, or something like that... Of course I read that with my tiny layperson brain so maybe I got it all wrong.
Also, I'm curious about micronized BPO, it's not available where I live, am I missing out?
Can it help in treating KP?
hmm in theory it can help. But for KP, glycolic, salicylic acid, and high level urea creams have actually a lot more clinical evidence!