I've had anxiety and severe insomnia for years. Ended up addicted to benzos but Zoloft+Remeron has been a life changer. Drastically reduced my Xanax intake and currently working my way down to 0.
Thank you doctor. You seem genuinely passionate about explaining our medication to us. It might feel like you’re just making videos for whoever to watch but we really do appreciate it thank you
I'm on mirtazipine too on 30 mg and lately I been taking tiny bites of 1 pill through out the day and it really helps out , helping me feel more better and less depressed and anxious
I don't want to sound overly dramatic, but I swear that discovering about, and taking, this drug has been one of the most important life-changing things I've ever done in my life. I went from like 10-20min of REM sleep for YEARS to literally 2 hours per night. I don't have any side-effects, and I don't feel groggy or weird. I think I just got so used to feeling in a fog from years and years of exhaustion. I only take 3.75mg, which is half of the lowest kiddie dose 7.5mg and I am out within an hour or two. It doesn't seem to disrupt sleep architecture in a negative way, it feels like it improves natural sleep. After 2-3 days of starting this, it was the first time in like a decade or more that I didn't feel tired. It's been a miracle. Thanks for the in-depth video!
Have you gained any weight from it? My Dr just prescribed it to me for insomnia (7.5mg at bedtime) and I’m hesitating to take it because of the weight gain side effect that seems to plague so many that take it. I took it a couple of nights and the next morning I felt like a Mac truck had ran over me 😮
I was treated by you for a skin issue, you are one of the last great Doctors of the greatest generation of doctors! 25 years ago when I got treated here in Las Vegas I knew you were special but you were ONLY doing Dermatology. Please keep up your good works, and thank you for your tireless efforts to improve the quality of life for your patience and people all over the world, through the information dissemination of your pharmacological understanding and the videos you produce and provide us at YOUR OWN EXPENSE! Once again Thank you: John Petzold
You are a great man! This medicine began helping me after about 25 days at 30 mg. I've been suffering with depression, insomnia, and physical pain from Fibromyalgia. I've been watching most of your videos for years now and I've learned more from you than any doctor. I am so greatful and I appreciate your knowledge and respect you so much. I do believe you have changed my life as I am no longer suicidal, I was able to sleep last night and I woke up feeling like a new person. I was SSRI intolerant and I could not tolerate any medication all my life till now. At first this medication did cause some side effects but I just kept taking them as I had no other hope of help. I feel as though my life just changed overnight. What a father's day gift this is. I wish I could shake your hand and thank you. The very best to you doctor I will forever be thankful to you.
It's crazy how polarized the view on these drugs is. Some people swear by them, others go out of their way to condemn them. It's a shame because people considering these drugs are most likely terrified of these subjective anecdotal reviews. I know I am.
I 100% feel the same. Its so so difficult to take new medication when feeling depressed and hearing all the conflicting reports on it, it basically becomes impossible to commit. All we want to do is get better but it's so terrifying trying to decide what's best for us.
Couldn't agree more. I've been given these just today by my doc and I've spent the evening on the Internet reading reviews. I'm scared to start them now
Littalwabbit - Sometimes there is a good reason to be scared. I wish someone had told me how difficult and painful it can be to try to get off mirtazapine. I never would have taken it.
You Sir, are a hero of mine. Your knowledge and expertise is incredibly outstanding and I for one do not takeit for granted. Thank You for the time and informative videos! 🙏👍👍
I have bipolar type 1. I take zyprexa (olanzapine) and zoloft (sertraline), and recently mirtazapine. My life has done nothing but improve since taking Mirtazapine. This medication can be applied to bipolar treatment so long as you're on a mood stabiliser or antipsychotic.
Certainly am. I'm doing a lot more activities, and finally have a normal life because I'm not looking at life through the filter of depression. I have held a job for a long time and yes you're right. The antipsychotic or mood stabilizer prevents mania. However I think it's only a risk of mania when you first start taking it. I finally have my life back. I'm driving cars, have a wholesome relationship and actually have energy now thanks to this medication. I think the mirtazapine only increased the serotonergic behaviour, once bipolar people adjust to taking it, we're fine :)
Thank you for the information, I started with 7.5 due to loss of appetite , depression and lost of sleep !! First night I slept 12 hours well needed rest.. 🙏🏻🙏🏻🦋🦋
Do you keep it at 7.5 and still does the job? Or did you have to increase it to 15 and then 30? Would love to have your opinion. My anxiety is brutal to the point of not eating. I Don’t tolerate IRSS’s. THANK YOU!
Yo Rutherford thank you. I’ll see my doctor this afternoon. I’m in Spain and the lowest dose here is 15. I’ll mention your case. I might start tonight, just don’t want to be drowsy forever. Cross my fingers. Thank you!
Yo Rutherford Just saw the Dr. He suggested 7.5 to fight anxiety. Do not need a higher dose because I’m not depressed. Just anxious/phobic. He said to take it as I needed it, not daily. Do you take it daily or when need it? THANK YOU!
Wow. I also have cptsd with insomnia and depression anxiety etc. I have tries countless ssria and snris and none have worked. Sleep is my main issue i cant never turn off even ambien and diazepam i quickly built a tolerance. I hope this can help. How long did it take for you to feel benefits and how much are you taking? :)
@@harness84_29 I HAVE THE SAME ISSUE I CANNOT FALL ASLEEP WHEN I NEED TO, my brain doesn't fucking turn off all I think about is that I'm thinking about me thinking about me thinking, it doesn't stop and I have to stay awake over 12 hours until my body makes me pass out from fatigue, ITS SO HARD TO KEEP A JOB LIKE THIS i don't know what to do. I have tried quetiapine and NEVER EVER again will I touch that stuff. it made me so sick and my heart kept racing
I don't know if you read a comment I made on a previous video asking if you'd cover Remeron or you just covered it but thank you for this. My partner has been on these for several years and I really needed a brief overview of the medicine. Great channel 👍🏾 Update: after years of Remeron my partner has finally been free of this drug for 8 days.
@@yuh-zeeds414 Yes Yuh-zeed, she is still off the medicine and apparently the withdrawal symptoms vary due to factors such as dose and time taken. She has had lethargy, heightened anxiety, panic, nausea, loss of appetite, flu like symptoms (aches and pains, generally feeling unwell) Hope this answers your question and gives you some idea of what to expect.
Yup very helpful thanks! I hope you don’t mind asking more questions: - What was the dose she was on mostly? - Does she still experience any of the withdrawal symptoms after stopping her meds for 3 months or so?
This is the one drug that actually made me sober from beer 🍺 for a short time 😉 until I stopped taking it... I drink because of anxiety and antisocial problems.. as well as insomnia restless leg syndrome .. the drug did everything beer did for me ... Without the devastating effects on my liver... Minus ➖ getting buzzed
This man reassured me, im starting treatmeant this evening, Hope i'll be better, even though taking medication to treat what seems like a subjective lack of mood and sleep to me doesnt make me happy, After many Years of not finding a solution with my own ressources, you at least gotta try Good Luck to everyone dealing with depression, i'll keep you up to date with how im feeling if people are interested Have a good day everyone
Day 1 - could not resist the sleeping urge (didnt slept last night though), felt a little bit of diziness and dry mouth, but slept pretty well. Waking UP was rough but managed. Regarding mood, i dont feel any different.
@@stevej4328 i would say im doing good, still taking it, and what i said on my previous comment is still true to this day, everything is mostly positive, im still working on myself to improve but i'll get there eventually i think
When I was taking this it really helped with sleep which was such a relief. I did put on a huge amount of weight as it caused massive cravings for carbs but I lost this weight once I stopped taking it. I didn’t have anything serious in terms of withdrawal unlike when I was taking Paxil/Seroxat (paroxetine). I managed to (accidentally) cross-taper with Prozac (fluoxetine) and just stop any anti-depressants for a few years.
He did leave out one crucial fact that you should be aware of though, Mirtazapine is an antichollinergic substance meaning it lowers acetylcholine levels in the brain and throughout the body. Acetylcholine is one of the most essential compounds to us as humans, it regluates sleep, histamine production, memory, visual preception, mood, and more. This is bad in the case of mirtazapine because you want to have acetylcholine, but mirtazapine being a muscarinic receptor antagonist blocks our body from producing normal levels of acetylcholine. Side effects of antichollinergic use include, dry mouth, hot and cold flashes, depression, anxiety, early onset dementia, alzhimers, delirium, psychosis, intoxication, brain fog, insomnia, narcolepsy, and parkinsons disease due to dopamine suppression caused by antichollinergics. www.accessdata.fda.gov/drugsatfda_docs/label/2016/020415s030lbl.pdf www.ncbi.nlm.nih.gov/pmc/articles/PMC5383251/ www.health.harvard.edu/mind-and-mood/two-types-of-drugs-you-may-want-to-avoid-for-the-sake-of-your-brain I encourage you to read these articles if you really want to know what this drug can do, check this website out www.erowid.org/pharms/mirtazapine/
Great sources and references. Nevertheless, Mirtazipine is outrageously being prescribed like Aspirin. What can you say about it. Big Pharma. Beat It. “ Not a controlled substance”. Yet it’s as strong as Valium/Xanax in my opinion. Makes you sleepy as literally hell.
@@hicko92 Yes I agree, this guys channel does seem to be more informative than most channels, but on occasion, stuff does get left out. I've actually been on mirtazipine for a short period of time and while I had no long lasting issues from it, it honestly sucked, made me tired not just the night I took it, but the entire next day, I had no motivation to do anything but sleep, I couldn't think straight, and I felt more depressed to be completely honest.
@@hicko92 yes that’s for sure. My new Dr prescribed it to me for insomnia, in her opinion my usual 6mg of Ambien was ‘way too dangerous’… holy crap. I took the Remeron before bed and the next morning I felt like a Mac truck had run over me… and I was so wobbly on my legs all day, just stumbling around. With Ambien I just feel normal when I wake up. 🫤
@@jesseibarra5301 … It did work for the anxiety, but it was making him super sleepy, even giving it to him at night it would still carry over into the next day, so we can’t give it to him consistently…
@@funkyflights the fog the following day, goes away after a week or two. It's best to persist. 15mg is the smallest dose used for anxiety and depression.
@keyboard warrior Hello there, yes I'm alot less anxious on them. Been on them just over 2 weeks so hopefully I haven't felt the full benefit yet since it takes 4-6 weeks they say, so hopefully I'll feel even better then. Helping me sleep has made a huge difference too. Just takes a strong cup of tea to wake up and I need to get used to that for returning to work. How long have you been on Mirtz for ?
@@zonnebloem100 Yes although it could be time mending things as well. Increased appetite and a little groggy in the mornings are the only SE's I've experienced.
@@michaelthau1007 hi Michael. No I haven’t gained any weights at all as I exercise frequently. It doesn’t give me next day sedation either. I can’t notice any side effects at all. All the best and hope you are well, too.
I had a seizure on the second day after taking a total of two fifteen mg doses and I’m not an epileptic. I immediately stopped and saw my doctor after a month or so. He didn’t believe me and represcribed the same dosage. Same thing. On day two I had another seizure and immediately stopped. I saw the doctor again after another month went by and he basically called me a liar and gave me the same prescription again. No way in hell am I ever taking that drug again. I’m a 50 year old male that had a PE induced cardiac arrest two years ago. I take five mg of eloquis twice a day. Ever hear of anything like my story before?
I believe you , I had the same thing happen but my mum was there when it happened and it wasn't a seizure it was fainting that looked like a seizure a little
Thankyou so much, for dumbing it down, very well explained ,I dropped from metazapine 45mg to 30mg overnight, 3 days in I felt like death this morning, hopefully it gets better, thanks again .
@@nerdbamarich2063 its like all pharma, you feel good one minute then the next awful, back to 45, seems ok atm, getting few hours of good sleep mixed with melatonin , thanks for asking, I hope you are well
@@patty-ow9ul definitely pulling for you to get through my friend. I'm dealing with insomnia and anxiety but I'm afraid of medicine and I'll be seeing a psychiatrist on Tuesday. Have you been on any other meds before and how would you rate it compared to this
@@nerdbamarich2063 I appreciate that thanks, yeah taken lot of painkillers aswell, be very very careful in what they prescribe you, do your homework before necking them,I seen one of those dudes, he gave me some dodgey drug, the people that had took, literally said they were the devil, there words exactly , when I said I wasn't taking them, he got pissed off, I knew that very second I done the right thing,the mirtazapine, were just from my doctor (gp),them haven't seemed to bad,what I found, they turn the volume down on the world and kindov in your head aswell.
@@patty-ow9ul you are more than welcome definitely will keep you in my prayers your comment really moved me. I think I'm dealing with long covid because I never had anxiety and insomnia like this. I've been to the hospital several times. My regular doctor wants to put me on Zoloft but I think they cause impotence in men. I started looking at this one because it's supposedly helps sleep. I have nocturnal panic attacks that wake me up with high heart rates and shaking. I'm at my Wit's end right now. Honestly don't know what to do.
I was prescribed this as an appetite stimulant but it didn't work, I later found out it hasn't been found to have stimulated appetite in people who aren't depressed. I wish I had been told this earlier
@@mlynnofficial2164 it realy helps .i visit my doctor in Zürich (Switzerland)every month twice .i hope u will enjoy it with treatment .after 6 months everything gonna be alright.
@@eddynoe there is many medicine that can help u to give back your social acctivty in every aspect in life ,and my adivise as a former depressive is just visit the nearest hospital and don't shay to tell your feelings because if u hide it today u will regret one day, i hope u will be fine god pless u👋
I take it every night I have realistic dreams every single night which is pretty cool and it makes u very hungry as well but the dreams are pretty cool even the nightmare
I was on Mirtazapine for 5 years, I can't say with a definite surety but I had very negative effects I can definitely tie to the drug. For me the side effects outweigh any beneficial clinical affect. I stayed on it for the length of time I did because I had tried at least Seven or eight different antidepressants.
Mental fog, and a whole new type of anxiety, at least for me. I also had sleep issues from very odd dreams to being incredibly tired and not being able to sleep. For me it's a real long list from moderate to severe in range of side effects. It is not something you can know and then you just avoid the medication because the side effects you MIGHT HAVE ARE VERY DIFFERENT FROM PERSON TO PERSON. BUT DOING YOUR OWN RESEARCH IS VERY IMPORTANT AND SMART BECAUSE IT WILL HELP YOU UNDERSTAND THE RISKS AND POSSIBLE SIDE EFFECTS! I HOPE THAT HELPS!
YESSSSSSSSS I JUST WATCHEED THIS VID EXPECTING TO NOT WANNA TAKE IT BECAUSE ALL THE OTHER DRUGS HAVE SHITTY SIDE EFFECTS ESPECIALLY ED. IM GOING TO REALLY GIVE THIS ONE A GO PLUS I HAVE DEPRESSION INSOMNIA AND IM UNDERWEIGHT. THANKYOUUUUUUUU
@@maybenotsure5380 holy shit, I have really bad insomnia and depression and I just had a really bad experience on quetiapine (heart palpitations, SUPER dizzy, nearly passing out, feeling sick to my stomach) after having these effects I decided to look into medications so much more and thousands of other people have had what I went through, the feeling of dread/panic attacks sound similar to this, my doctor has just recommended mirtazapine to me so I've looked it up, if there is so much as a chance of anything CLOSE to what I went through I'm not going near it. I just need something to help me sleep when I have work the next day. Not one single doctor has been able to be honest with me and talk to me about helping me fall asleep they never speak about these experiences. they want to prescribe me things that have affects on other aspects and not something that helps me sleep, I've lost jobs to this sleep issue and I feel like I will lose my current one too if this keeps happening, it can take me up to 6 hours to fall asleep and if I need to wake up at 5 in the morning it's just not possible like that. I guess my question is, when you started this medication did you have negative effects like the ones I experienced? seeing you reply to YOUR OWN comment about how awful it was has made me even more sceptical about taking it which is a good thing I think.
@@hypnotherapist2211 it was horrible. I was on it for 5 1/2 months suffered horrible side effects. I was told to wait 6 to 8 weeks and the side effects should subside, but they never subsided at which point my doctor decided that I was on too long of a dose, and we need to increase it which only increased the side effects. I honestly after this experience don’t think I will ever try another antidepressant when I went in for my 5 1/2 month visit. My blood pressure was so high that my doctor cold turkey took me off of it. I did another two months of absolute suffering. I’m still not right. But this is just my experience your experience might be completely different.
Mirtazipine is also a muscarinic receptor antagonist, which when taken long term is shown to raise the chances of early onset dementia and alzheimers disease. Muscarinic receptor antagonists are known to also cause hot and cold flashes, delirium, brain fog, fatigue, dry mouth, dehydration, vertigo, Parkinson's disease and brain damage if taken for a long period of time. This is why antihistamines like benadryl, promethazine, and doxylamine are so dangerous as they work in the same manner, I really think that this should be mentioned, for a lot of people it could make depression worse. It's not a very safe drug even though it's been approved by the fda.
I sure as heck feel like I have dementia if I’m even able to wake up at all. There’s a reason this med has been eclipsed. I’ve only taken it once so far & don’t feel like being in a coma the next 1-2 weeks hoping those side effects go away. Awful
@@fistwood Yes. I have a couple sources, as well as general knowledge about muscarinic receptor antagonists and they all behave similarly. www.accessdata.fda.gov/drugsatfda_docs/label/2016/020415s030lbl.pdf www.ncbi.nlm.nih.gov/pmc/articles/PMC5383251/ www.health.harvard.edu/mind-and-mood/two-types-of-drugs-you-may-want-to-avoid-for-the-sake-of-your-brain Muscarinic Receptor antagonists are a group of drugs that help with allergies, things like promethazine, doxylamine, diphenhydramine, mirtazapine, atropine, scopolamine, and hyoscamine just to name a few. Some do exibit serotonergic effects, however they all exibit anticholinergic effects. Anticholinergic effects can be desireable in some cases, however, even in these cases, its still doing damage to your brain. Anticholinergic substances are linked to early onset dementia, fatigue, erectile dysfunction, loss of muscle control, parkinsons disease due to dopamine suppression, restless leg symdrome, dry mouth, depression, anxiety, cardiotoxic effects, and more. Doesnt sound worth the risk for its reletivly low success rate if you ask me. I've experienced anticholinergic toxcisity a couple times myself and its not pleasant, most poisons are actually antichollinergics. So i would be careful.
@Smatt All my sources say the anticholinergic properties are moderately strong, if youd like to provide info on this, I'll gladly look through it. Honestly even if it isnt a very potent anticholinergic, it still is one, prolonged use leads to inhibition of certain enzymes like with most anticholinergics, slowing the metabolism of this substance, so it does build up eventually. Even if you dont feel it effecting you. If a whole community is dedicated to taking it recreationally for its deliriant effects, it's likely potent enough to cause some damage, even weak anticholinergics like chlorpheniramine and brompheniramine have some toxic anticholinergic effects even though they're generally no where near the potency of stronger ones. It is a weak inhibitor of the CYP1A2, CYP2D6, and CYP3A4, these are all responsible for metabolism of mirtazipine and its metabolites. Its half life is also 20-40 hours, so when you take your next dose, you still have a good deal of the drug in your system. en.m.wikipedia.org/wiki/Mirtazapine#Pharmacokinetics pubmed.ncbi.nlm.nih.gov/10885584/
@Smatt that study was conducted in 1995, one year before mirtazipine was fda approved and it was only available in the Netherlands for one year prior to this article being published. I don't want to sit here and argue, yes it is probably not the most potent anticholinergic substance out there, but you still cant deny that it does have some anticholinergic effects, which generally speaking isnt good. Where do you think its sedative effects come from? Its serotonin antagonism? Or its adrenergic effects? You tell me
After removal of 2 mg lopezlday for 2 weeks I was prescribed hydroxyzine 25 mg. my body couldn't tolerate it (due to side effects of tremors/ chills) with trying 3 days & nor any positive affect on my nauseous+panic state. I was than prescribed mirtaz 7.5 mg therefore took it & next day i was very much relieved from my anxious state with low headache still there which i was suffering from 1 month. Now the side effects were at next noon with dizzi & confused statw of mind with electric shocks like feeling for 2 hrs. Afterwards ok ok with headache, panics. But constantly drowsiness with sedation effects on in day too. .. hekping with my condition.❤❤ Also a self help books as i couldn't afford a therapist. I started one i.e "Feeling good feel better" ❤❤❤
Can you post a video on loxapine or one on typical antipsychotics in general? I personally prefer the first generation drugs and would like to know what you think about that
Hi Dr. Landow, I just watched quite a few of your videos on antipsychotics. I was looking for your opinion on which might be the best one for bipolar depression. I'd like your insight. I look forward to your response. Thank you. Sorry, I didn’t mean to sound presumptuous. I’m hoping you reply, not expecting you to.
@@zahararay5611 Hi Zahara, With great advances in medical science these days we have multiple choices when it comes to medication. So your psych may have selected something else which he felt could work for you. Take care and get better soon
How are you getting on with it? Drs started me on it yesterday. Slept amazingly but had vivid dreams and feel spacey and tiered today but apparently this settles after a few weeks. I wouldn’t be too worried about weight gain as I’m on pain meds that can cause the same and really increase your appetite, I just make sure I don’t go over the amount of calories my body needs and manage to keep the weight off that way.
I hope it’s all going well for you. My experience with this medication was all good except for the huge weight gain over 4 years on this medication 45kg horrible. I hope you don’t go through anything like this. Good health to you and thanks for sharing
@@nerdbamarich2063 Hi, I had to stop taking it after a few months as I was sleeping for 18hrs a day on it and when I was awake I felt like a zombie and my anxiety got much worse and I was having auditory hallucinations. I developed really loud tinnitus too while taking it which was really scary but that’s gone now I’ve stopped thank goodness.
I was also wondering if another symptom apart from my huge 45kg weight gain from mirtazapine is in the morning I wake up with anxiety ? I’m worried about myself
I was prescribed Mirtazapine 15mg daily back in September 2019 for my depression. The sleep I had on it was incredible, I’d fall asleep 20 to 30 minutes after taking the medication. Only trouble would be waking up, I’d find it rather hard to wake up because the sleep was so deep. I did find myself getting slightly hungrier on the medication, having the occasional late night snack but no weight gain. I met with a therapist while I was on the medication to talk about my depression and she was shocked when I told her I was on the medication, worrying about the ‘weight gain’ side effects. I never went back to that therapist lol I’ve slowly tried to stop the medication as I want to prove to myself that I can sleep without but my success has been varied
I put 40 lbs on mirtazapine 15 after just a few months. Didn't even change my diet or eat any differently despite craving sugar (I even weigh my food since I have a restricted diet). Mirtazapine is the AD which causes the most weight gain, there are several studies proving it and that agrees with my Dr's experience as well. You're lucky not to have this side effect.
The underplaying of withdrawal symptoms is breathtaking. Completely opposite to the lived experiences of thousands of users struggling for years to get off this lethal drug. No wonder peer support is all people have in this arduous journey
This gentleman must get paid from the drug companies Psychiatry acts like there is no withdrawal from these meds I know many many people who have had to do year long tapers to get off this drug
This has saved my life, with my anxiety i could never sleep, now within 1hr i am knocked out. Although the best dosage i found for me is 15mg + 1/4 tablet, anything more makes feel like a zombie. I tried Paxal and effexor with no help towards sleep
I was put on Effexor plus a mood stabilizer for unipolar depression. As a result I ended up being described by family members as a zombie for ten years. I also had insomnia for this period and as a result entered my sixties with memory problems. During this period I cared for both parents with dementia. I came off the mood stabilizer to find myself terrified the memory problems were an indicator of having dementia myself. Try and find out as much as possible about the side effects of these drugs/poisons. The doctors give us these while we are at one of the most vulnerable time of our lives. Be safe
I've been taking Mirtazapine 30mg for 12 years. Prescribed them due to insomnia.They usually work, but I take a Zopiclone occasionally too. The only side effect I experience is dry mouth, which is trivial.
i've been taking it for 7 years. it revitalized my appetite and helped treat my depression at first but i think it might've caused me to develop a facial tic
Any women here 35 to 55 going through peri menopause/menopause been prescribed this? What’s your dosage and side affects? How long have you been on this drug? Please let’s share information so we can all make an informed decision about wether to take it or not!? Thanx
I used it in a form of tablet not the dissolvent from, for a year and half. I am addicted to it. Now I am experiencing withdrawals. I have no appetite and digestive issues, plus a racing heart and panic attacks. How can I come off if it and combat these withrawal symptoms.
WARNING: Mirt or Remeron destroyed my ability to sleep. While on it, I took Ativan to sleep occasionally. After 18 months on it, was cold turkeyed off it and the sleep issues resolved three days later. But then six months later, another bout of no sleep...i fall asleep every few minutes but wake up the second I go under, then jolt awake either from not breathing or from the electricity in my brain (possibly adrenaline rush?) Eight years off Remeron, and seven years off Ativan and still having severe bouts of insomnia for several days every month or so.
@tyrel prescribed Ativan for insomnia caused by menopause. No I am not healed. I cannot live a normal life. Most days are a real struggle...so much weird pain, brain zaps, unbelievable bouts of paranoia and irrational fears. I used to be smart and normal prior to Ativan.
@tyrel every semblance of normalcy was taken from me with the first 80 mg of Ativan taken over 2 years. I only took it occasionally and still ended up in protracted support groups. My last long spell of normalcy was ten days in January 2020. It's been a real life nightmare that everyone finds hard to believe except others harmed by benzos. If you're not in a support group, find one, please.
Doctor. I am put on the beginner's dose which is 15mg. It is so sedative that 7.5mg keeps me asleep for 24. I am a very tall. Overweight even for my height. Why can't my body tolerate this drug? I am going to try a quarter of a pill I guess? Why do people have such varying reaction to the sedative effect of this drug?
I have a lot of disorders. Already have zoloft for 9 years. But only im doing so good with remeron and zoloft both. But i wish someday that i have zoloft can leave behind.
I was on Mirtazepine. It helped some for insomnia. The big, intolerable side effect was sexual disfunction, ed and anti orgasmic. Love and sex are too important for happiness so I had to ween off the drug slowly.
@@bigd4115 ... yes... Remeron helped me sleep some. It also was less disruptive for ED. I could get it up, hard. The problem was then, I was non orgasmic...I could go for hours and not spill my load !! Women loved it, but I could not come...no matter how sexy they were... !!! 😭 even at low doses. Very very frustrating.
Why didn't my pharmacist inform me of all this today when I picked up my prescription... Kidding, sorta. Only warning was sleepiness. This was an impressive array of informative facts in about as short a time frame as it could possibly be done in a fairly easy to understand way. Thank you. Doc has me starting half of a 15mg dose. Easing me in and I'm sure will ease me out if need be. I feel relatively safe taking this relatively well tolerated medication.
I had pretty much ALL of the adverse reactions to mirtazapine. The first real nausea inducing migraine I've ever had, my tinnitis got dialed to 11, and I felt like my mind was a rag doll being thrown around by an angry child, and for 24 long hours, every 15 minutes like clockwork, my mood would totally collapse into crying catatonic mess. The only thing I didn't do is go blind.
It's amazing how different people react to Mirtazapine. I've had virtually no adverse effects to it. It's worked brillint for me, I hope they manage to find a AD which works for you.
I have the effects...i dont know what else to take for sleep...it makes me way to tired and causes headaches which makes it too difficult to drift into sleep
I was prescribed on this med after trying so many antidepressants ,I still didn t take it cause I m scared after what happened to me taking prozac ,does someone know if Mirtazapin helps with bad dreams as well ? Thanks
I have daytime anxiety so I’m taking half in the morning and half in the afternoon as I have panicked attacks And 15mg at night for sleep I’m depressed anxious insomnia etc Would u recommend Seroquel instead for daytime anxiety?
@@zonnebloem100 Hi Truss I like you have ringing in the ears,don’t have the rest of the symptoms you have . I use to take mirtasapine purely so i could stay a sleep and not have to wake up in the middle of the night listening to my head buzz !! But because of the association between antidepressants and ringing in the ears (it scared me) I desisted..hope your coping ok ?
@@zonnebloem100 It could be totally coincidental that I developed tinnitus!! I have no other problems .. the main reason for taking matazapine was for insomnia.. Hope this helps Truus
I was on 60-70mg Mirtaz but I had to lower down because it would trigger my restless leg. Now I have 30mg Mirtaz and 10mg Olanz for my insomnia and anxiety, and have clonazepam for my restlessness which works wonders and I am able to finally able to have more consistent sleep.
@@jack-nq7vroh wow good to know I’ve heard horror stories about withdrawals I’m on night 2 of 15mg Did you gain weight? I have anxiety panic attacks depression insomnia etc Was sleep talking last night I record myself on my phone at night
![ลองสุ่มไอโฟน 990 โกงมั้ย? [ โกงมั้ยครับ ep.101 ] | DOM](http://i.ytimg.com/vi/bfsWe0j492k/mqdefault.jpg)
This doctor left nothing out such a wealth of unstoppable knowledge. I can image that all your patients certainly get their money's worth
I've had anxiety and severe insomnia for years. Ended up addicted to benzos but Zoloft+Remeron has been a life changer. Drastically reduced my Xanax intake and currently working my way down to 0.
Thank you doctor. You seem genuinely passionate about explaining our medication to us. It might feel like you’re just making videos for whoever to watch but we really do appreciate it thank you
Can mirtazapine help with losing blood pressure
Yesss
I'm on mirtazipine too on 30 mg and lately I been taking tiny bites of 1 pill through out the day and it really helps out , helping me feel more better and less depressed and anxious
@@ryanjacques5553 it can raise BP 😮
@@tylersoto7465 mirt is not a long-term solution
I wanna have a doctor like you who explains with detail what you’re getting into your system
On of the best doctors in this platform. Very smart and professional. Thank you doctor
I don't want to sound overly dramatic, but I swear that discovering about, and taking, this drug has been one of the most important life-changing things I've ever done in my life. I went from like 10-20min of REM sleep for YEARS to literally 2 hours per night. I don't have any side-effects, and I don't feel groggy or weird. I think I just got so used to feeling in a fog from years and years of exhaustion. I only take 3.75mg, which is half of the lowest kiddie dose 7.5mg and I am out within an hour or two. It doesn't seem to disrupt sleep architecture in a negative way, it feels like it improves natural sleep. After 2-3 days of starting this, it was the first time in like a decade or more that I didn't feel tired. It's been a miracle. Thanks for the in-depth video!
Thank you for the feedback 😀
'Seek ye not peace in Hebrew Herbs, but in the blood of the lamb.
Which is my blood.
Amen.
Gerontology.Ch.4, verse 3.
Have you gained any weight from it? My Dr just prescribed it to me for insomnia (7.5mg at bedtime) and I’m hesitating to take it because of the weight gain side effect that seems to plague so many that take it. I took it a couple of nights and the next morning I felt like a Mac truck had ran over me 😮
@@Johnconno by
You split the 30mg poll to 8 small pieces;
I was treated by you for a skin issue, you are one of the last great Doctors of the greatest generation of doctors! 25 years ago when I got treated here in Las Vegas I knew you were special but you were ONLY doing Dermatology.
Please keep up your good works, and thank you for your tireless efforts to improve the quality of life for your patience and people all over the world, through the information dissemination of your pharmacological understanding and the videos you produce and provide us at YOUR OWN EXPENSE!
Once again Thank you: John Petzold
Did he pass away?
@greg1483 Unfortunately, he did 😢
@@motasemabumoghli 😫
@@motasemabumoghli Nooooo!
He was my Dermatologist also. Excellent Doctor!
This guy knows his stuff.
Just look at him ofc he does
Maybe I missed it but I didn't see a single jump cut in the whole video, nor did it look like he was reading from a script. Wish he was my Doctor!
He's probably ready it
@@damodaraomalley3974 NO.
Yessss
He is the perfect human being, innit
You are amazing. Thanks for your in-depth information! You have helped me understand my medication so much better!
Lots of information, makes me a bit scared to try it.
You are a great man!
This medicine began helping me after about 25 days at 30 mg. I've been suffering with depression, insomnia, and physical pain from Fibromyalgia.
I've been watching most of your videos for years now and I've learned more from you than any doctor.
I am so greatful and I appreciate your knowledge and respect you so much.
I do believe you have changed my life as I am no longer suicidal, I was able to sleep last night and I woke up feeling like a new person.
I was SSRI intolerant and I could not tolerate any medication all my life till now. At first this medication did cause some side effects but I just kept taking them as I had no other hope of help.
I feel as though my life just changed overnight.
What a father's day gift this is.
I wish I could shake your hand and thank you.
The very best to you doctor I will forever be thankful to you.
What side effects did you have?
@@mrc.p8423 Weight gain and dry mouth in the morning. I cannot take off the weight even if I stop eating for several days and maintain a liquid diet.
@@youknowcrimedontpay9257 but it did what it was supposed to?
@@mrc.p8423 For depression? Yes..
@@youknowcrimedontpay9257 you lose weight by working out not eating won’t help
It's crazy how polarized the view on these drugs is. Some people swear by them, others go out of their way to condemn them. It's a shame because people considering these drugs are most likely terrified of these subjective anecdotal reviews. I know I am.
I 100% feel the same. Its so so difficult to take new medication when feeling depressed and hearing all the conflicting reports on it, it basically becomes impossible to commit. All we want to do is get better but it's so terrifying trying to decide what's best for us.
Couldn't agree more. I've been given these just today by my doc and I've spent the evening on the Internet reading reviews. I'm scared to start them now
@@jonburrows2883 ive had my bottle for a month I’m still scared
@@jonburrows2883 I use to be the same. It doesn't help us. Best to take and see how they work for each individual.
Littalwabbit - Sometimes there is a good reason to be scared. I wish someone had told me how difficult and painful it can be to try to get off mirtazapine. I never would have taken it.
You Sir, are a hero of mine. Your knowledge and expertise is incredibly outstanding and I for one do not takeit for granted. Thank You for the time and informative videos! 🙏👍👍
I am using this’s medicine for the last seven years.it helps a lot for sleep.
How much you take? Is it making you aggressive and irritated
Any side effects
how many minutes you take after dinner?
@@naseermushtaq4968for me severe nightmares but cool dreams, hard almost impossible to wake up, and next day feels like I escaped a bad trip 😂 😢
What dosage did you gain weight? Are you still on it
I have bipolar type 1. I take zyprexa (olanzapine) and zoloft (sertraline), and recently mirtazapine. My life has done nothing but improve since taking Mirtazapine. This medication can be applied to bipolar treatment so long as you're on a mood stabiliser or antipsychotic.
Hi. Why it is taken with antipsychotic? I just want to find out the reason why my doctor prescribed two medecines first is ssri and antipsychotic.
@@esma.ga5 Woth bipolar antidepressants can cause mania so that’s why I think they need to be on a mood stabiliser, to maybe curb the mania.
hi . how you doing till today?
Also are you still on it or ?
Thank you
Certainly am. I'm doing a lot more activities, and finally have a normal life because I'm not looking at life through the filter of depression. I have held a job for a long time and yes you're right. The antipsychotic or mood stabilizer prevents mania. However I think it's only a risk of mania when you first start taking it.
I finally have my life back. I'm driving cars, have a wholesome relationship and actually have energy now thanks to this medication. I think the mirtazapine only increased the serotonergic behaviour, once bipolar people adjust to taking it, we're fine :)
Did you gain weight
U are a. Great Dr. May u be blessed
blessed by what or who?
Thank you for the information, I started with 7.5 due to loss of appetite , depression and lost of sleep !! First night I slept 12 hours well needed rest.. 🙏🏻🙏🏻🦋🦋
How are you now the doctor give that for insomnia..
Do you keep it at 7.5 and still does the job? Or did you have to increase it to 15 and then 30? Would love to have your opinion. My anxiety is brutal to the point of not eating. I Don’t tolerate IRSS’s. THANK YOU!
@@Stanley_Ellis im still on 7.5 doing a good job so far 👍😎
Yo Rutherford thank you. I’ll see my doctor this afternoon. I’m in Spain and the lowest dose here is 15. I’ll mention your case. I might start tonight, just don’t want to be drowsy forever. Cross my fingers. Thank you!
Yo Rutherford Just saw the Dr. He suggested 7.5 to fight anxiety. Do not need a higher dose because I’m not depressed. Just anxious/phobic. He said to take it as I needed it, not daily. Do you take it daily or when need it? THANK YOU!
I have complex PTSD. And Mirtazapine took away all of my angels of thoughts
Wow. I also have cptsd with insomnia and depression anxiety etc. I have tries countless ssria and snris and none have worked. Sleep is my main issue i cant never turn off even ambien and diazepam i quickly built a tolerance. I hope this can help. How long did it take for you to feel benefits and how much are you taking? :)
@@harness84_29 I HAVE THE SAME ISSUE I CANNOT FALL ASLEEP WHEN I NEED TO, my brain doesn't fucking turn off all I think about is that I'm thinking about me thinking about me thinking, it doesn't stop and I have to stay awake over 12 hours until my body makes me pass out from fatigue, ITS SO HARD TO KEEP A JOB LIKE THIS i don't know what to do. I have tried quetiapine and NEVER EVER again will I touch that stuff. it made me so sick and my heart kept racing
Intelligent man. Thank you for making this video. Appreciate your time, effort and knowledge
I don't know if you read a comment I made on a previous video asking if you'd cover Remeron or you just covered it but thank you for this. My partner has been on these for several years and I really needed a brief overview of the medicine. Great channel 👍🏾
Update: after years of Remeron my partner has finally been free of this drug for 8 days.
Hello. Any updates on your partner overall health after stopping Remeron? Any severe Withdrawal symptoms?
@@yuh-zeeds414 Yes Yuh-zeed, she is still off the medicine and apparently the withdrawal symptoms vary due to factors such as dose and time taken. She has had lethargy, heightened anxiety, panic, nausea, loss of appetite, flu like symptoms (aches and pains, generally feeling unwell)
Hope this answers your question and gives you some idea of what to expect.
Yup very helpful thanks!
I hope you don’t mind asking more questions:
- What was the dose she was on mostly?
- Does she still experience any of the withdrawal symptoms after stopping her meds for 3 months or so?
@@yuh-zeeds414 Okay so she hasn't been off them for that long, she was on 45mg for over a year.
Withdrawal symptoms from remeron?
Brains here we have... well done on your medical advice! Wish I had a brain like yours
This is the one drug that actually made me sober from beer 🍺 for a short time 😉 until I stopped taking it... I drink because of anxiety and antisocial problems.. as well as insomnia restless leg syndrome .. the drug did everything beer did for me ... Without the devastating effects on my liver... Minus ➖ getting buzzed
You're an absolute fountain of knowledge. Thanks for the thorough run through of the pharmacology and so much more!
This man reassured me, im starting treatmeant this evening, Hope i'll be better, even though taking medication to treat what seems like a subjective lack of mood and sleep to me doesnt make me happy, After many Years of not finding a solution with my own ressources, you at least gotta try
Good Luck to everyone dealing with depression, i'll keep you up to date with how im feeling if people are interested
Have a good day everyone
Day 1 - could not resist the sleeping urge (didnt slept last night though), felt a little bit of diziness and dry mouth, but slept pretty well. Waking UP was rough but managed. Regarding mood, i dont feel any different.
@@amraneanis6749 how are you now
@@amraneanis6749 how are you now?
@@stevej4328 i would say im doing good, still taking it, and what i said on my previous comment is still true to this day, everything is mostly positive, im still working on myself to improve but i'll get there eventually i think
@@amraneanis6749 Great to hear!
You are a pretty cool youtube dr, I just got prescrbied this for PTSD, so i was worried after SSRI usage - this made me feel better
Have you taken it Paul?
How was it
Ha, Finally a med that Ken doesn't put on blast. Must be a winner. :)
This man is so easy so listen to
When I was taking this it really helped with sleep which was such a relief. I did put on a huge amount of weight as it caused massive cravings for carbs but I lost this weight once I stopped taking it. I didn’t have anything serious in terms of withdrawal unlike when I was taking Paxil/Seroxat (paroxetine). I managed to (accidentally) cross-taper with Prozac (fluoxetine) and just stop any anti-depressants for a few years.
very good talk, I am stoping taking it today.
Great informative video. Covered pretty much all the aspects and specifications of Remeron.
He did leave out one crucial fact that you should be aware of though, Mirtazapine is an antichollinergic substance meaning it lowers acetylcholine levels in the brain and throughout the body. Acetylcholine is one of the most essential compounds to us as humans, it regluates sleep, histamine production, memory, visual preception, mood, and more. This is bad in the case of mirtazapine because you want to have acetylcholine, but mirtazapine being a muscarinic receptor antagonist blocks our body from producing normal levels of acetylcholine.
Side effects of antichollinergic use include, dry mouth, hot and cold flashes, depression, anxiety, early onset dementia, alzhimers, delirium, psychosis, intoxication, brain fog, insomnia, narcolepsy, and parkinsons disease due to dopamine suppression caused by antichollinergics.
www.accessdata.fda.gov/drugsatfda_docs/label/2016/020415s030lbl.pdf
www.ncbi.nlm.nih.gov/pmc/articles/PMC5383251/
www.health.harvard.edu/mind-and-mood/two-types-of-drugs-you-may-want-to-avoid-for-the-sake-of-your-brain
I encourage you to read these articles
if you really want to know what this drug can do, check this website out
www.erowid.org/pharms/mirtazapine/
Great sources and references. Nevertheless, Mirtazipine is outrageously being prescribed like Aspirin. What can you say about it. Big Pharma. Beat It. “ Not a controlled substance”. Yet it’s as strong as Valium/Xanax in my opinion. Makes you sleepy as literally hell.
@@hicko92 Yes I agree, this guys channel does seem to be more informative than most channels, but on occasion, stuff does get left out. I've actually been on mirtazipine for a short period of time and while I had no long lasting issues from it, it honestly sucked, made me tired not just the night I took it, but the entire next day, I had no motivation to do anything but sleep, I couldn't think straight, and I felt more depressed to be completely honest.
@@hicko92 I want to use it in small amount to taper off Clonazepam.
@@hicko92 yes that’s for sure. My new Dr prescribed it to me for insomnia, in her opinion my usual 6mg of Ambien was ‘way too dangerous’… holy crap. I took the Remeron before bed and the next morning I felt like a Mac truck had run over me… and I was so wobbly on my legs all day, just stumbling around. With Ambien I just feel normal when I wake up. 🫤
My Dad was just prescribed this for anxiety after a stroke … This was great information, thanks !
Did it work?
@@jesseibarra5301 … It did work for the anxiety, but it was making him super sleepy, even giving it to him at night it would still carry over into the next day, so we can’t give it to him consistently…
@@funkyflights thank you for responding I hope He recovers fast. What dose is he on?
@@jesseibarra5301 …. Thanks … 15 milligram tab and sometimes we go half dose so 7.5 milligrams, it makes him super sleepy
@@funkyflights the fog the following day, goes away after a week or two. It's best to persist. 15mg is the smallest dose used for anxiety and depression.
Went onto mirtazapine after 20 years on sertraline best thing l did
Did u taper from one to the other? Or just switch. Any issues or side effects.
15mg of Mirtazapine has worked for me, groggy first few days but once in my system sleeping like a baby and I'm feeling better all round.
@keyboard warrior Hello there, yes I'm alot less anxious on them. Been on them just over 2 weeks so hopefully I haven't felt the full benefit yet since it takes 4-6 weeks they say, so hopefully I'll feel even better then. Helping me sleep has made a huge difference too. Just takes a strong cup of tea to wake up and I need to get used to that for returning to work.
How long have you been on Mirtz for ?
The main side effect is appetite but I've always had a sweet tooth.
@@zonnebloem100 Yes still on 15 mg after 4 weeks. I'm taking it for obtrusive thoughts.
@@zonnebloem100 Yes although it could be time mending things as well. Increased appetite and a little groggy in the mornings are the only SE's I've experienced.
@@zonnebloem100 Good luck with you bud :)
I’ve been on Mirtazipine for nearly 6 months now, it greatly helps with anxiety and sleep.
Does it have sexual side effects?
@@EE-ie9gm it doesn’t to me.
Hi Jason
Was prescribed 7.5 mg for insomnia.
Didn't try it yet afraid of weight gain and next day sedation? Any bad side effects?
Hope you are well
@@michaelthau1007 hi Michael. No I haven’t gained any weights at all as I exercise frequently. It doesn’t give me next day sedation either. I can’t notice any side effects at all. All the best and hope you are well, too.
How you doing now? What dosage did you start on?
Mirtazapine is great in lower doses if you have insomnia, not so much in higher doses.
I had a seizure on the second day after taking a total of two fifteen mg doses and I’m not an epileptic.
I immediately stopped and saw my doctor after a month or so.
He didn’t believe me and represcribed the same dosage.
Same thing. On day two I had another seizure and immediately stopped.
I saw the doctor again after another month went by and he basically called me a liar and gave me the same prescription again.
No way in hell am I ever taking that drug again.
I’m a 50 year old male that had a PE induced cardiac arrest two years ago.
I take five mg of eloquis twice a day.
Ever hear of anything like my story before?
what the hell. ur doc should be sued what an aweful person
Why did you go to your doctor a month after having a literal seizure.
I believe you , I had the same thing happen but my mum was there when it happened and it wasn't a seizure it was fainting that looked like a seizure a little
Thankyou so much, for dumbing it down, very well explained ,I dropped from metazapine 45mg to 30mg overnight, 3 days in I felt like death this morning, hopefully it gets better, thanks again .
How is it making you feel?
@@nerdbamarich2063 its like all pharma, you feel good one minute then the next awful, back to 45, seems ok atm, getting few hours of good sleep mixed with melatonin , thanks for asking, I hope you are well
@@patty-ow9ul definitely pulling for you to get through my friend. I'm dealing with insomnia and anxiety but I'm afraid of medicine and I'll be seeing a psychiatrist on Tuesday. Have you been on any other meds before and how would you rate it compared to this
@@nerdbamarich2063 I appreciate that thanks, yeah taken lot of painkillers aswell, be very very careful in what they prescribe you, do your homework before necking them,I seen one of those dudes, he gave me some dodgey drug, the people that had took, literally said they were the devil, there words exactly , when I said I wasn't taking them, he got pissed off, I knew that very second I done the right thing,the mirtazapine, were just from my doctor (gp),them haven't seemed to bad,what I found, they turn the volume down on the world and kindov in your head aswell.
@@patty-ow9ul you are more than welcome definitely will keep you in my prayers your comment really moved me. I think I'm dealing with long covid because I never had anxiety and insomnia like this. I've been to the hospital several times. My regular doctor wants to put me on Zoloft but I think they cause impotence in men. I started looking at this one because it's supposedly helps sleep. I have nocturnal panic attacks that wake me up with high heart rates and shaking. I'm at my Wit's end right now. Honestly don't know what to do.
Thank you so much for such rigorous research.
This video was incredible. Thank you so much!
I was prescribed this as an appetite stimulant but it didn't work, I later found out it hasn't been found to have stimulated appetite in people who aren't depressed. I wish I had been told this earlier
What was your dose though? It matters.
I just was prescribed this for appetite I’m so nervous
Thanks for such a detailed explanation. Really helpful.
Tomas mirtazapina? Y si es así, cómo te va? Me da miedo empezar
Best doctor ever right to the point
Mirtazapin-Mepha 30 mg helps me to find back my appitite.sleep and it decreased my depretion thanks all the doctors around the world
Does it really help ? I have major anxiety and I’m on medicine for it and it takes me months to actually take something new I’m considering it tonight
@@mlynnofficial2164 it realy helps .i visit my doctor in Zürich (Switzerland)every month twice .i hope u will enjoy it with treatment .after 6 months everything gonna be alright.
Aryan Ali Thank you so much I think I will start it tonight !
Did it increase your libido?
@@eddynoe there is many medicine that can help u to give back your social acctivty in every aspect in life ,and my adivise as a former depressive is just visit the nearest hospital and don't shay to tell your feelings because if u hide it today u will regret one day, i hope u will be fine god pless u👋
I take it every night I have realistic dreams every single night which is pretty cool and it makes u very hungry as well but the dreams are pretty cool even the nightmare
Wonderful video!
Does this cause any heart arrhythmia?
Thank you
Evet olur kalbinizin ritmini bozar
I was on Mirtazapine for 5 years, I can't say with a definite surety but I had very negative effects I can definitely tie to the drug. For me the side effects outweigh any beneficial clinical affect.
I stayed on it for the length of time I did because I had tried at least Seven or eight different antidepressants.
What were the effects
Mental fog, and a whole new type of anxiety, at least for me.
I also had sleep issues from very odd dreams to being incredibly tired and not being able to sleep. For me it's a real long list from moderate to severe in range of side effects. It is not something you can know and then you just avoid the medication because the side effects you MIGHT HAVE ARE VERY DIFFERENT FROM PERSON TO PERSON. BUT DOING YOUR OWN RESEARCH IS VERY IMPORTANT AND SMART BECAUSE IT WILL HELP YOU UNDERSTAND THE RISKS AND POSSIBLE SIDE EFFECTS!
I HOPE THAT HELPS!
@@johnpetzold7318 what type of anxiety ,were you angry , irritable?
@@Србомбоница86 I was.
@@Србомбоница86 Hi Beautiful - you are so gorgeous!
Really grateful for these videos I learn a lot because of them
Oh man when he said “California rocket fuel” I dropped the phone on my face 😂😂 oh man I would love to sit in his class. Thanks for the video sir!
I missed it!? When does he say it and what the hell is it? It sounds delicious arhahah
How hard to get off this med
Wonderful explanation
YESSSSSSSSS I JUST WATCHEED THIS VID EXPECTING TO NOT WANNA TAKE IT BECAUSE ALL THE OTHER DRUGS HAVE SHITTY SIDE EFFECTS ESPECIALLY ED. IM GOING TO REALLY GIVE THIS ONE A GO PLUS I HAVE DEPRESSION INSOMNIA AND IM UNDERWEIGHT. THANKYOUUUUUUUU
It was absolutely awful the panic attacks and sweating and feelings of dread.
@@maybenotsure5380 holy shit, I have really bad insomnia and depression and I just had a really bad experience on quetiapine (heart palpitations, SUPER dizzy, nearly passing out, feeling sick to my stomach) after having these effects I decided to look into medications so much more and thousands of other people have had what I went through, the feeling of dread/panic attacks sound similar to this, my doctor has just recommended mirtazapine to me so I've looked it up, if there is so much as a chance of anything CLOSE to what I went through I'm not going near it. I just need something to help me sleep when I have work the next day. Not one single doctor has been able to be honest with me and talk to me about helping me fall asleep they never speak about these experiences. they want to prescribe me things that have affects on other aspects and not something that helps me sleep, I've lost jobs to this sleep issue and I feel like I will lose my current one too if this keeps happening, it can take me up to 6 hours to fall asleep and if I need to wake up at 5 in the morning it's just not possible like that. I guess my question is, when you started this medication did you have negative effects like the ones I experienced? seeing you reply to YOUR OWN comment about how awful it was has made me even more sceptical about taking it which is a good thing I think.
@@maybenotsure5380 this is what it did to me as well now I have to taper off worst mistake ever!!!!
@@bluestar7757 how long was you on ot for and how are you now.
@@hypnotherapist2211 it was horrible. I was on it for 5 1/2 months suffered horrible side effects. I was told to wait 6 to 8 weeks and the side effects should subside, but they never subsided at which point my doctor decided that I was on too long of a dose, and we need to increase it which only increased the side effects. I honestly after this experience don’t think I will ever try another antidepressant when I went in for my 5 1/2 month visit. My blood pressure was so high that my doctor cold turkey took me off of it. I did another two months of absolute suffering. I’m still not right. But this is just my experience your experience might be completely different.
Well I'm going to give it another chance. Does it keep getting better for you?
Sometimes a month is about the apex. Very nice. Thankyou.
Mirtazipine is also a muscarinic receptor antagonist, which when taken long term is shown to raise the chances of early onset dementia and alzheimers disease. Muscarinic receptor antagonists are known to also cause hot and cold flashes, delirium, brain fog, fatigue, dry mouth, dehydration, vertigo, Parkinson's disease and brain damage if taken for a long period of time. This is why antihistamines like benadryl, promethazine, and doxylamine are so dangerous as they work in the same manner, I really think that this should be mentioned, for a lot of people it could make depression worse. It's not a very safe drug even though it's been approved by the fda.
I sure as heck feel like I have dementia if I’m even able to wake up at all. There’s a reason this med has been eclipsed. I’ve only taken it once so far & don’t feel like being in a coma the next 1-2 weeks hoping those side effects go away. Awful
can you tell me where is your information from?
@@fistwood Yes. I have a couple sources, as well as general knowledge about muscarinic receptor antagonists and they all behave similarly.
www.accessdata.fda.gov/drugsatfda_docs/label/2016/020415s030lbl.pdf
www.ncbi.nlm.nih.gov/pmc/articles/PMC5383251/
www.health.harvard.edu/mind-and-mood/two-types-of-drugs-you-may-want-to-avoid-for-the-sake-of-your-brain
Muscarinic Receptor antagonists are a group of drugs that help with allergies, things like promethazine, doxylamine, diphenhydramine, mirtazapine, atropine, scopolamine, and hyoscamine just to name a few. Some do exibit serotonergic effects, however they all exibit anticholinergic effects. Anticholinergic effects can be desireable in some cases, however, even in these cases, its still doing damage to your brain. Anticholinergic substances are linked to early onset dementia, fatigue, erectile dysfunction, loss of muscle control, parkinsons disease due to dopamine suppression, restless leg symdrome, dry mouth, depression, anxiety, cardiotoxic effects, and more. Doesnt sound worth the risk for its reletivly low success rate if you ask me. I've experienced anticholinergic toxcisity a couple times myself and its not pleasant, most poisons are actually antichollinergics. So i would be careful.
@Smatt All my sources say the anticholinergic properties are moderately strong, if youd like to provide info on this, I'll gladly look through it. Honestly even if it isnt a very potent anticholinergic, it still is one, prolonged use leads to inhibition of certain enzymes like with most anticholinergics, slowing the metabolism of this substance, so it does build up eventually. Even if you dont feel it effecting you. If a whole community is dedicated to taking it recreationally for its deliriant effects, it's likely potent enough to cause some damage, even weak anticholinergics like chlorpheniramine and brompheniramine have some toxic anticholinergic effects even though they're generally no where near the potency of stronger ones. It is a weak inhibitor of the CYP1A2, CYP2D6, and CYP3A4, these are all responsible for metabolism of mirtazipine and its metabolites. Its half life is also 20-40 hours, so when you take your next dose, you still have a good deal of the drug in your system.
en.m.wikipedia.org/wiki/Mirtazapine#Pharmacokinetics
pubmed.ncbi.nlm.nih.gov/10885584/
@Smatt that study was conducted in 1995, one year before mirtazipine was fda approved and it was only available in the Netherlands for one year prior to this article being published. I don't want to sit here and argue, yes it is probably not the most potent anticholinergic substance out there, but you still cant deny that it does have some anticholinergic effects, which generally speaking isnt good. Where do you think its sedative effects come from? Its serotonin antagonism? Or its adrenergic effects? You tell me
Great job 👏👏
After removal of 2 mg lopezlday for 2 weeks I was prescribed hydroxyzine 25 mg. my body couldn't tolerate it (due to side effects of tremors/ chills) with trying 3 days & nor any positive affect on my nauseous+panic state. I was than prescribed mirtaz 7.5 mg therefore took it & next day i was very much relieved from my anxious state with low headache still there which i was suffering from 1 month. Now the side effects were at next noon with dizzi & confused statw of mind with electric shocks like feeling for 2 hrs. Afterwards ok ok with headache, panics. But constantly drowsiness with sedation effects on in day too. .. hekping with my condition.❤❤
Also a self help books as i couldn't afford a therapist. I started one i.e "Feeling good feel better" ❤❤❤
Thanks for such a great informative video!
Wow will you be my psychiatrist?? Lol ❤. I just discovered your channel and you seem to know more than any of my past and current doctors. ❤
He is dead unfortunately.
Can you post a video on loxapine or one on typical antipsychotics in general? I personally prefer the first generation drugs and would like to know what you think about that
Hi Dr. Landow, I just watched quite a few of your videos on antipsychotics. I was looking for your opinion on which might be the best one for bipolar depression. I'd like your insight. I look forward to your response. Thank you. Sorry, I didn’t mean to sound presumptuous. I’m hoping you reply, not expecting you to.
Symbyax works well for bipolar depression and mild to moderate psychosis.
@@viktorb8905 Hi Viktor, Thank you for your reply. I'm going to look it up. I wonder why my psychiatrist never mentioned this one.
@@zahararay5611 Hi Zahara, With great advances in medical science these days we have multiple choices when it comes to medication. So your psych may have selected something else which he felt could work for you. Take care and get better soon
If you watched his many other videos you should know that he never replies to comments on TH-cam.
J Y good to know. Thank you.
I’ve just been prescribed this. I’m terrified of weight gain though.
How are you getting on with it? Drs started me on it yesterday. Slept amazingly but had vivid dreams and feel spacey and tiered today but apparently this settles after a few weeks. I wouldn’t be too worried about weight gain as I’m on pain meds that can cause the same and really increase your appetite, I just make sure I don’t go over the amount of calories my body needs and manage to keep the weight off that way.
How you doing on them Greg?
I hope it’s all going well for you. My experience with this medication was all good except for the huge weight gain over 4 years on this medication 45kg horrible. I hope you don’t go through anything like this. Good health to you and thanks for sharing
@@willow2290 how is it helping you so far and are you still on it?
@@nerdbamarich2063 Hi, I had to stop taking it after a few months as I was sleeping for 18hrs a day on it and when I was awake I felt like a zombie and my anxiety got much worse and I was having auditory hallucinations. I developed really loud tinnitus too while taking it which was really scary but that’s gone now I’ve stopped thank goodness.
I was also wondering if another symptom apart from my huge 45kg weight gain from mirtazapine is in the morning I wake up with anxiety ? I’m worried about myself
I was prescribed Mirtazapine 15mg daily back in September 2019 for my depression.
The sleep I had on it was incredible, I’d fall asleep 20 to 30 minutes after taking the medication. Only trouble would be waking up, I’d find it rather hard to wake up because the sleep was so deep. I did find myself getting slightly hungrier on the medication, having the occasional late night snack but no weight gain.
I met with a therapist while I was on the medication to talk about my depression and she was shocked when I told her I was on the medication, worrying about the ‘weight gain’ side effects. I never went back to that therapist lol
I’ve slowly tried to stop the medication as I want to prove to myself that I can sleep without but my success has been varied
I put 40 lbs on mirtazapine 15 after just a few months. Didn't even change my diet or eat any differently despite craving sugar (I even weigh my food since I have a restricted diet). Mirtazapine is the AD which causes the most weight gain, there are several studies proving it and that agrees with my Dr's experience as well. You're lucky not to have this side effect.
OreElect1
Are you sure its 2-5% every 2-4 weeks?
I
OreElect1
I hear its 20%
OreElect1
Omg!
That’s why my son is messed up then
OreElect1
Is there a way I can talk to you?
Email or anything
Dr. Landow - please do a video on metropolo and eliquis to regular an a-fib patient with no bp issues. no other meds, Vegan for 9 yrs clean arteries).
Since day 1 I had a terrible RLS about 1 hour after taking it so I couldn t sleep at all.Absolutely not gonna continue taking this medication.
Ur the best man god bless u and ur family
The underplaying of withdrawal symptoms is breathtaking. Completely opposite to the lived experiences of thousands of users struggling for years to get off this lethal drug. No wonder peer support is all people have in this arduous journey
Could you go a little more in depth? Who died from this drug? What were your negative side effects?
Please explain, thank you in advance
This gentleman must get paid from the drug companies
Psychiatry acts like there is no withdrawal from these meds
I know many many people who have had to do year long tapers to get off this drug
It absolutely has withdrawals even with a slow taper headache no appetite stomach pain nausea sweating hot cold flashes
Wow this is fantastic info!! Thank u for your channel❤️
You are so welcome!
This has saved my life, with my anxiety i could never sleep, now within 1hr i am knocked out. Although the best dosage i found for me is 15mg + 1/4 tablet, anything more makes feel like a zombie. I tried Paxal and effexor with no help towards sleep
Are you still taking it and did you have any side effects?
I was put on Effexor plus a mood stabilizer for unipolar depression. As a result I ended up being described by family members as a zombie for ten years. I also had insomnia for this period and as a result entered my sixties with memory problems. During this period I cared for both parents with dementia. I came off the mood stabilizer to find myself terrified the memory problems were an indicator of having dementia myself. Try and find out as much as possible about the side effects of these drugs/poisons. The doctors give us these while we are at one of the most vulnerable time of our lives. Be safe
I've been taking Mirtazapine 30mg for 12 years. Prescribed them due to insomnia.They usually work, but I take a Zopiclone occasionally too. The only side effect I experience is dry mouth, which is trivial.
Did you have Dizziness
@@Fortunately8 I have none
Did it ever make you trip? I mean, the psychedelic kind of trip, not falling over.
@@psilocybe8135 wish I can...get find tbe m mushrooms
@@garysimone4977 Mitrazapine gives me many of the same effects as m mushrooms, that's why I asked. Doesn't seem to affect many others that way though.
I desparetly want to try this medication. I have been on Wellbutrin ER 300mg. Can I stop taking Welibutrin for 4 days and then start mitazapine?
I take both ! They work well together
Does anyone know if potential side effects happen when you first start Mirtazipine or can they start even after you’ve take it for 5 years?
i've been taking it for 7 years. it revitalized my appetite and helped treat my depression at first but i think it might've caused me to develop a facial tic
This doctor has and always been one to explain effacacy of the drug he is speaking about.I always come away with a good informations wirh my concernes
Do a video on Serax
Any women here 35 to 55 going through peri menopause/menopause been prescribed this? What’s your dosage and side affects? How long have you been on this drug? Please let’s share information so we can all make an informed decision about wether to take it or not!? Thanx
I used it in a form of tablet not the dissolvent from, for a year and half. I am addicted to it. Now I am experiencing withdrawals. I have no appetite and digestive issues, plus a racing heart and panic attacks. How can I come off if it and combat these withrawal symptoms.
Discuss with your doctor x
Finalmente pudiste dejar Mirta?
Do you have appetite now
@@nidhivaidya2869 I am taking it again
What mg where you taking and how long? If you don’t mind me asking and did you go back on because of withdraw?
Which is better, anafranil or mirtazapine?
Yeah, I can read the long med info insert, too.
WARNING: Mirt or Remeron destroyed my ability to sleep. While on it, I took Ativan to sleep occasionally. After 18 months on it, was cold turkeyed off it and the sleep issues resolved three days later. But then six months later, another bout of no sleep...i fall asleep every few minutes but wake up the second I go under, then jolt awake either from not breathing or from the electricity in my brain (possibly adrenaline rush?) Eight years off Remeron, and seven years off Ativan and still having severe bouts of insomnia for several days every month or so.
Could be sleep apnea if you stop breathing your body will jolt you awake
@@elijahdungan3612 Tested twice, two sleep studies said I don't have sleep apnea. It's akathisia in the brain, nervous system.
@tyrel prescribed Ativan for insomnia caused by menopause. No I am not healed. I cannot live a normal life. Most days are a real struggle...so much weird pain, brain zaps, unbelievable bouts of paranoia and irrational fears. I used to be smart and normal prior to Ativan.
@tyrel left work in 2012. Still can't work. I sleep enough 2-3 nights per week.
@tyrel every semblance of normalcy was taken from me with the first 80 mg of Ativan taken over 2 years. I only took it occasionally and still ended up in protracted support groups. My last long spell of normalcy was ten days in January 2020. It's been a real life nightmare that everyone finds hard to believe except others harmed by benzos. If you're not in a support group, find one, please.
Doctor. I am put on the beginner's dose which is 15mg. It is so sedative that 7.5mg keeps me asleep for 24. I am a very tall. Overweight even for my height. Why can't my body tolerate this drug? I am going to try a quarter of a pill I guess? Why do people have such varying reaction to the sedative effect of this drug?
I have a lot of disorders. Already have zoloft for 9 years. But only im doing so good with remeron and zoloft both. But i wish someday that i have zoloft can leave behind.
im on 45mg feel like i’m constantly tipsy doesn’t help much with depression anymore. fucks up my concentration but i do find it easier to sleep.
Does it keep you from having insomnia and has it caused any sexual problems
I was on Mirtazepine. It helped some for insomnia. The big, intolerable side effect was sexual disfunction, ed and anti orgasmic. Love and sex are too important for happiness so I had to ween off the drug slowly.
Research shows that it's suppose have lower side effects for ed and sexual dysfunction? did u try lowering dosage
@@bigd4115 ... yes... Remeron helped me sleep some. It also was less disruptive for ED. I could get it up, hard. The problem was then, I was non orgasmic...I could go for hours and not spill my load !! Women loved it, but I could not come...no matter how sexy they were... !!! 😭 even at low doses. Very very frustrating.
@@bigd4115 I would assume lower doesn't mean none.
Hasn't stopped me, I'm still king of the bedroom, nah, seriously no effect here.
@@persevere4 ..good...shoot your loads. !!!
you have avery blaze attitude Dr, about this drug, it has it's place but a nightmare to come off
Does this medicine(mirtazapine) cause fatty liver or liver damage? Please reply🙏🏼
He's dead
@@Prometheushighaf 😢
Remeron felt like my skull was placed under a bulldozer
I wish I could have both sertraline and mirtazapine....that would be a dream.
That's what I'm taking.
Me too.
did it increase motivation/ energy????
50mg of paroxetinum did it for me + 150mg wellbutrin
Why didn't my pharmacist inform me of all this today when I picked up my prescription... Kidding, sorta. Only warning was sleepiness.
This was an impressive array of informative facts in about as short a time frame as it could possibly be done in a fairly easy to understand way.
Thank you.
Doc has me starting half of a 15mg dose. Easing me in and I'm sure will ease me out if need be. I feel relatively safe taking this relatively well tolerated medication.
What's the difference between 15mg and 30mg for social anxiety?
sedation... at low dose more sedation
I had pretty much ALL of the adverse reactions to mirtazapine. The first real nausea inducing migraine I've ever had, my tinnitis got dialed to 11, and I felt like my mind was a rag doll being thrown around by an angry child, and for 24 long hours, every 15 minutes like clockwork, my mood would totally collapse into crying catatonic mess. The only thing I didn't do is go blind.
It's amazing how different people react to Mirtazapine. I've had virtually no adverse effects to it. It's worked brillint for me, I hope they manage to find a AD which works for you.
What dose were you on? Is worsening tinnitus a side effect?
@@patw8187 Apparently it is. 2 days of low initial dose and my brain went "nope!" both times.
I have the effects...i dont know what else to take for sleep...it makes me way to tired and causes headaches which makes it too difficult to drift into sleep
@@zonnebloem100 Yes.
I was prescribed on this med after trying so many antidepressants ,I still didn t take it cause I m scared after what happened to me taking prozac ,does someone know if Mirtazapin helps with bad dreams as well ? Thanks
It gives you very vivid dreams
Allways Hungry!!! Weight Gain extreme, and devoloping Insulin Resistance, never never take Miratazapine
Will 7.5 mg mirtazapine be enough for anxiety. I'm extremely sensitive meds.
This medication causes major weight gain.
I have daytime anxiety so I’m taking half in the morning and half in the afternoon as I have panicked attacks
And 15mg at night for sleep
I’m depressed anxious insomnia etc
Would u recommend Seroquel instead for daytime anxiety?
Does it cause ringing in the ears the doc made a reference to it which is something in of its self would depress you massively
@@zonnebloem100
Hi Truss
I like you have ringing in the ears,don’t have the rest of the symptoms you have . I use to take mirtasapine purely so i could stay a sleep and not have to wake up in the middle of the night listening to my head buzz !! But because of the association between antidepressants and ringing in the ears (it scared me) I desisted..hope your coping ok ?
@@zonnebloem100
It could be totally coincidental that I developed tinnitus!! I have no other problems .. the main reason for taking matazapine was for insomnia.. Hope this helps Truus
Not every one can tolerate those doses. 15 is to much for me. Need to start lower.
Lower dose means more sedation. Higher dose is better tolerated.
@@zippeduniform3 i take 7.50 mg and is ok for me for sleep
I was on 60-70mg Mirtaz but I had to lower down because it would trigger my restless leg. Now I have 30mg Mirtaz and 10mg Olanz for my insomnia and anxiety, and have clonazepam for my restlessness which works wonders and I am able to finally able to have more consistent sleep.
After my three years of taking Mirtaz never felt any withdrawals and I have abruptly stopped it several times
@@jack-nq7vroh wow good to know I’ve heard horror stories about withdrawals I’m on night 2 of 15mg
Did you gain weight? I have anxiety panic attacks depression insomnia etc
Was sleep talking last night
I record myself on my phone at night
@@jack-nq7vr??