@@vikasafonowa I'm sure there are. You'll want to look for bioenergetic diagrams. I've always found them in physiology textbooks which are copywrite and I can't share, but I'm sure they're published in articles as well
You did the best job of explaining Lactate, better than anything I've read or seen online. I just finished a hard run and can feel a significant difference at around 168 bpm. At around 175 bpm my body feels like it's in desperation mode!
Such a quality vid. You’ve covered this topic rly well on your channel almost no one talks abt atp hydrolysis or how our skeletal muscle gets into an undesirable acidic environment. Thanks
Would have been nice to add that: "Lactic acid only exists in sour milk". That would have ended the still ongoing confusion. :) But nice explanation of how lactate is produced.
Very helpful video. Just to clarify, since lactate is a BASE and helps to buffer the hydrogen ions… is lactic acid a real substance that even exists? Or is it just an inaccurate term that people use to refer to lactate? Lactate clearly exists and has uses. Is Lactic acid something separate or just not a real substance and a term that should be avoided entirely?
So helpful! Big question for you... I have Long Covid and am a life long endurance athlete (running and cycling). After a year of Long Covid I "have it under control" by using a HR monitor and ensuring I stay aerobic under 145 bpm. This approach has been working great for the past few months in avoiding any Long Covid relapses. I am convinced from my experiences that exercising even briefly in an anaerobic state can bring on a Long Covid relapse. I don't understand the biology that occurs, but from my reading the immune system in those of us with Long Covid over reacts from excessive exertion which "causes" the relapses with a flood of T-cells. My question is this.. Not only have I been using the HR monitor to avoid relapses I have also been increasing my glucose intake during exercise using energy drinks and exercise nutrition. This is unusual for me on a 2 hour mountain bike ride, as I historically use glucose stored in the body for 1-2 hours and replenish after the ride. I just took a guess that ensuring I had more glucose in the system during exercise I would raise the threshold or prolong the onset where I produced what I thought of as "lactic acid", but now understand as hydrogen ions. Do you think my use of my on-the-bike energy drinks and snacks helps or hurts my chances of getting into a state where I'm likely to have a relapse?
I have a question pertaining to that subject. Oxygenation is required for the oxidative phosphorylation. Increased mitochondria within muscle cells improve VO2Max. How is the capillarisation of muscle fibres improved to increse overall oxygen supply and what drives that process. How do I train for improvement of capillarisation? Does it have anything to do with aerobic threshold and lactate build up? I hop[e I am not confusing things too much.
This video is clear and easy to understand. But you don't mention that the kidneys also remove lactate. Is their contribution insignificant compared to the other pathways?
I assume most discomfort or pain is a signal by the body to help us prevent damage to ourselves. It sounds like this whole process is easily dealt with and casually cleared, so why is our body sending us the signal of discomfort? Is the signal an error or is there something going on we are being warned about?
yes. lmao probably doesn't matter for most people watching this video but that drove me nuts. was searching comments to see if anyone else noticed. some basic bio and chem flaws in that tidbit of the video
Just subscribed to your channel. Appreciate the informative video on this topic. Stumbled across this while trying to research the link between anaerobic high intensity exercise and increased levels of uric acid in the body that lead to gout flare ups which prevents further exercise. If you have any insight on this, would appreciate if you can share!
Really? It explained what lactate was in detail and then he used it synonymously with lactic acid later. So please can you tell me the difference between the 2 seeing how you understand the differences ?
@@jono1457-qd9ft I think we do, but it immediately dissociates and becomes a lactic salt (lactate), plus a hydrogen ion. Either way, lactate is a usable substrate that the body loves, and it doesn't cause acidosis.
I can get to a 150 hear rate from pedaling fast on medium resistance or pedaling slow on high resistance. What are the physiological causes for increased heart rate from higher resistance? What are the causes for increased heart rate from faster pace? Is something different impeding blooddlow for each?
Glycolysis is always happening, it starts to predominate not due to lack of oxygen, but due to ATP demand becoming higher than oxidative processes can handle by themselves. Substrate (lactate) builds up if you do not have the oxidative capacity to feed it all back into TCA in a timely manner. The protons build up perhaps because there are not molecules on standby to be reduced by them fast enough. It is my understanding that glycolysis is like a machine gun. Though ATP yield is not high per glucose molecule, glycolysis can fire off ATP so fast that it is kinda unsustainable.
Thanks for the explanation !!! I sell a probiotic that produces only L-positive lactate and was wondering if you have done any videos on L-positive lactate vs D-negative lactate?
Very good video, thank you! Helped me clarify quite a bit. Could someone please just answer one question though, what exactly is lactic Acid then? Lactate is the pyruvate+H ion but what is lactic acid?
Lactate is not Pyruvate + H. He misspoke. Pyruvate + H would have been Pyruvic acid. Lactate is the reduced form of Pyruvate from the reaction: Pyruvate + NADH + H+ ----> Lactate + NAD+. Lactate is the conjugate base of Lactic acid, so a Lactate + H.
Theoretically speaking, what could cause a steap decrease in lactate threshold? I have been in really good shape over that past few years but have suffered a preceived decrease associated with an increase in inflammation. I beleive that this inflammation is contributing to nutrient deficiencies that, in turn, are shifting my metabolism from VERY flexible towards needing much more carbohydrates.
Is the heart rate related by some mathematical equation to the threshold? I see 155 for the runner on your video. I am just confused between VO2 max and threshold and Heart Rate on why we can not find a clear scientific equation that relates them (just like your perfect explanation for Lactate using Chemistry).
I think that a little clarification is needed. You say that lactate is being produced at the same time as hydrogen ions and that lactate accepts a hydrogen ion. However in the video “Lactic acid doesn’t cause muscle burn” you spell out that pyruvate+hydrogen ions = lactate. Is lactate formed by pyruvate combining with hydrogen ions or does lactate attach to hydrogen ions in performing a clearance function?
As far as i understand: 1. Pyruvate -> 2. lactate dehydrogenase (adding a total of 2 H+ molecules to pyruvate) (1 H+ from the NADH: co factor in this reaction and another 1 H+ molecule from …. Somewhere 😅) = Lactate
@@petermercadante630 Another clarification...It isn't two H+ being added to Pyruvate. Any dehydrogenase enzyme is "reducing" a molecule. That refers to giving that molecule electrons. H+ does not have any electrons, it's only a proton. NADH is giving two electrons to Pyruvate to reduce it while also giving it the Hydrogen atom. H+ comes from the surrounding acidity that always exists in the cell. In biology, H+ does not actually exist freely, it's understood to be H3O+ (Hydronium ion). So you can understand a Lactate anion as Pyruvate with two extra electrons and two extra protons.
@@Radjehuty Thank you contributing to this issue again. It is difficult to follow without the relevant scientific background but even to someone like me who does not have that background it seems that the science is not settled. When reading below please understand that I am just trying to summarise what I have read and am not trying to explain a process about which I know little. Hopefully I have not misstated their views. To summarise the points presented in this video: 1. Pyruvate “accepts” a hydrogen ion and forms lactate. 2. Hydrogen ions come from ATP hydrolysis which causes the PH level in the blood to drop causing acidosis. 3. Lactate buffers hydrogen ions out of the blood. 4. Lactate is produced at the same time as hydrogen ions but is a separate process. Andy Galpin has a well-received video online entitled “What lactate is and what it actually does” in which he says that pyruvate “attaches” to a hydrogen molecule to form lactate so that lactate may be viewed as pyruvate holding onto a hydrogen molecule. So they both seem fairly consistent in their description of what constitutes lactate. As an aside I note that you refer to “lactic acid” in the comments below, but these authors do not. In the Catalyst University video presentation “What is Lactate and Lactic Acid”, the author says that: 1. In conversion from pyruvate to lactate the lactate is already ionised so that there is no H+ to dissociate. 2. The H ions come from the “strong ion difference,” 3. This means that the H+ ions increase to counterbalance the negative charge from lactate and maintain plasma electro neutrality. Just to add to the confusion there is an online interview of Professor George Brooks well known for his work on lactate in which he states: 1.The body does not make lactic acid, 2. The end stage of glycolysis is pyruvate or lactate. He seems to suggest an “either” “or” which is contrary to all I’ve read about glycolysis. Attia seems surprised but lets it go. It is possible that Brooks was sidetracked or did not express that properly or that might be his actual view. 3. More controversially he asserted that lactate enters the mitochondria which Attia does say is contrary to everything he has learned and read. You say that lactate converts to lactic acid but one of the world's leading authorities (as do most others) seems to be against you. On what do you rely upon in support?
Long distance triathlete here. I have no science knowledge but I find that when I urinate that my muscles regroup when strained. Not sure if that helps with getting rid of lactate
“Most likely muscle tears”… this is similar to Dr Andrew Huberman’s to the same topic. He stated “most likely due to calcium movement”. He did state some was due to muscle tears however it seems to me this is a bit of a mystery. Thanks for the chemical breakdown process. This helps a great deal
The chemistry is a bit off. Once the lactate anion accepts the hydrogen ion, it is indeed called Lactic Acid. Lactate is the conjugate base. It's no different from any other acid-base reaction. Ammonia is a base and when it accepts a hydrogen, it becomes the Ammonium cation, its conjugate acid. Lactic acid can become a problem for those who are going into liver failure, lactic acidosis. Yes lactate can help buffer against the acidity of anerobic respiration but only up to a point.
…there is no such thing as a lactic acid burn…it’s the lowering of pH ( hydrogen ions )..of the localized area…which lowers O2 to the nerves…almost like the pain of neuropathy…whereas lactate ( base ) is used in the CORI Cycle … his explanation is excellent…
Yes there’s oxygen available at rest but some muscle fibers are just very glycolytic and primarily produce lactate due to very low mitochondria. There are probably other reasons as well that I’m not aware of
@@TheMovementSystem Yes, lactate is a fuel and there is a tendency that lactate flows from glycolytic to oxidative fibres, eg heart muscle (lactate shuttle theory). But the point is, in exercise lack of oxygen is not required that pyruvate converts to lactate - the amount of lactate produced is a function of glycolysis.
@@TheMovementSystem So say I'm a cyclist and I build some serious muscle in my upper body. (All else being equal) I would be able to clear lactate faster but the acidity in my blood isn't going to be lower than before? So theoretically, I would have to stop at the same effort, but my lactate levels would be lower? :D Or, could that pyruvate be 'freed' in other muscles and then be used again to buffer protons?
@@MrMattie725Those muscles consuming the lactate will still need oxygen to liberate the hydrogen ion so your capacity to clear the lactic acid is still going to be determined by your maximum oxygen uptake i.e VO2 max 👍
If the role of lactate is actually buffering the H+, which sounds like a good thing, why is the accumulating lactate in the body actually limit the performance? Great video BTW!
Why do you think accumulating lactate limits performance? In fact I think metabolic acidosis is what is likely limiting performance and lactic acid is just building up at the same time
Lactate's purpose isn't to buffer the system. Yes it does indeed help buffer, but its main purpose is to convert the NADH you're generating in glycolysis back to NAD+ to allow glycolysis to continue. Aerobic respiration has a maximum capacity and excess ATP and NADH will shut down the TCA cycle shunting pyruvate to lactate production shifting NADH back to NAD+. The liver must deal with Lactate though because when it buffers the acidity, it converts itself to its acidic form. If the liver fails, lactic acidosis can happen. The liver just performs gluconeogenesis with the lactic acid to give muscles glucose back.
How can anyone think lactic acid doesn't exist? It's just the conjugate of Lactate. If Lactate performs its job as a buffer, then by definition it becomes an acid.
????? wtf - you havent explained the difference at all. You in detail explained lactate then used it synonymous with lactic acid later on. misleading title
@@curly_wurly_7219 be grateful for what. A misleading title ? And my time wasted. Seems like you have zero to input here so perhaps take your own advice and grow up. 🛎️ end
@@curly_wurly_7219 did you even watch the video ? Tell you what smart ass hit me with the time stamp with when he explains the difference. Reread the title of the video. It’s not called “what is lactic acid “ which is all that’s explained. Come on go get your big boy pants on and explain to me why my comment is not justified ?? I will be waiting. See when you can’t because what I said is right , then get back into your box and stfu 🤫 !!
…to be truthful, it’s complex chemistry …and I understand why you don’t understand his precise explanation…ignore the replies who think you’re just a troll…
Studying for the CSCS? Make sure you join my study group on Facebook: facebook.com/groups/2415992685342170
Are there articles on these on PubMed? Would you recommend any literature to clarify the difference between lactate and lactic acid?
@@vikasafonowa I'm sure there are. You'll want to look for bioenergetic diagrams. I've always found them in physiology textbooks which are copywrite and I can't share, but I'm sure they're published in articles as well
@@TheMovementSystem Thanks )
You did the best job of explaining Lactate, better than anything I've read or seen online. I just finished a hard run and can feel a significant difference at around 168 bpm. At around 175 bpm my body feels like it's in desperation mode!
Thank you for clarifying the role of Lactate, but still didn't understand where does the lactic acid enter in all this process?
Sour milk.
It doesn’t. Technically we don’t make lactic acid
All i get that we may think lactate is acidic like lactid acid but its actually alkalaine
What a jewel your channel is!
Thank you, I am studying for my RDN exam and you explain this very well and connect the concepts to real life experiences.
I'm studying exercise science and this has really helped my brain understand the process. tysm
Brilliant video man- well presented, explained and recorded!
thank you for keeping it simple and adding good visuals to this video!!! 🎉
This was a ride back to chemistry classes great reminder for me and great explaination from you.
Such a quality vid. You’ve covered this topic rly well on your channel almost no one talks abt atp hydrolysis or how our skeletal muscle gets into an undesirable acidic environment. Thanks
Perfect explanation. I came across this video once I finished reading McArdle's EP book. You did a great job!
Would have been nice to add that: "Lactic acid only exists in sour milk". That would have ended the still ongoing confusion. :) But nice explanation of how lactate is produced.
THIS IS SOOOO GOOD!!! I love it.
This is the video I have been looking for!!
Very helpful video. Just to clarify, since lactate is a BASE and helps to buffer the hydrogen ions… is lactic acid a real substance that even exists? Or is it just an inaccurate term that people use to refer to lactate?
Lactate clearly exists and has uses.
Is Lactic acid something separate or just not a real substance and a term that should be avoided entirely?
This is an incredible explanation
Working on my CSCS and wanted more context out of textbooks. Thank you for this. I’ll be watching more videos!
Sweet. Make sure you also join my CSCS study group on Facebook: facebook.com/groups/2415992685342170/?ref=share
So helpful! Big question for you... I have Long Covid and am a life long endurance athlete (running and cycling). After a year of Long Covid I "have it under control" by using a HR monitor and ensuring I stay aerobic under 145 bpm. This approach has been working great for the past few months in avoiding any Long Covid relapses. I am convinced from my experiences that exercising even briefly in an anaerobic state can bring on a Long Covid relapse. I don't understand the biology that occurs, but from my reading the immune system in those of us with Long Covid over reacts from excessive exertion which "causes" the relapses with a flood of T-cells. My question is this.. Not only have I been using the HR monitor to avoid relapses I have also been increasing my glucose intake during exercise using energy drinks and exercise nutrition. This is unusual for me on a 2 hour mountain bike ride, as I historically use glucose stored in the body for 1-2 hours and replenish after the ride. I just took a guess that ensuring I had more glucose in the system during exercise I would raise the threshold or prolong the onset where I produced what I thought of as "lactic acid", but now understand as hydrogen ions. Do you think my use of my on-the-bike energy drinks and snacks helps or hurts my chances of getting into a state where I'm likely to have a relapse?
Thanks man! Now I understand the term lactate
I have a question pertaining to that subject. Oxygenation is required for the oxidative phosphorylation. Increased mitochondria within muscle cells improve VO2Max. How is the capillarisation of muscle fibres improved to increse overall oxygen supply and what drives that process. How do I train for improvement of capillarisation? Does it have anything to do with aerobic threshold and lactate build up? I hop[e I am not confusing things too much.
You rock 👊🏻. Great video!
SO SO HELPFUL!
This video is clear and easy to understand. But you don't mention that the kidneys also remove lactate. Is their contribution insignificant compared to the other pathways?
Subscribed. Great information and well presented . Thanks.
I assume most discomfort or pain is a signal by the body to help us prevent damage to ourselves. It sounds like this whole process is easily dealt with and casually cleared, so why is our body sending us the signal of discomfort? Is the signal an error or is there something going on we are being warned about?
When pyruvate is reduced to lactate, the proton comes from NADH not from ATP hydrolysis
yes. lmao probably doesn't matter for most people watching this video but that drove me nuts. was searching comments to see if anyone else noticed. some basic bio and chem flaws in that tidbit of the video
Just subscribed to your channel. Appreciate the informative video on this topic. Stumbled across this while trying to research the link between anaerobic high intensity exercise and increased levels of uric acid in the body that lead to gout flare ups which prevents further exercise. If you have any insight on this, would appreciate if you can share!
This video is really helpful to understand the differences btw lactic acid and lactate. Thank you! :)
You’re welcome
Really? It explained what lactate was in detail and then he used it synonymously with lactic acid later. So please can you tell me the difference between the 2 seeing how you understand the differences ?
We don't produce lactic acid.
@@jono1457-qd9ft I think we do, but it immediately dissociates and becomes a lactic salt (lactate), plus a hydrogen ion. Either way, lactate is a usable substrate that the body loves, and it doesn't cause acidosis.
I can get to a 150 hear rate from pedaling fast on medium resistance or pedaling slow on high resistance.
What are the physiological causes for increased heart rate from higher resistance?
What are the causes for increased heart rate from faster pace?
Is something different impeding blooddlow for each?
Glycolysis is always happening, it starts to predominate not due to lack of oxygen, but due to ATP demand becoming higher than oxidative processes can handle by themselves. Substrate (lactate) builds up if you do not have the oxidative capacity to feed it all back into TCA in a timely manner. The protons build up perhaps because there are not molecules on standby to be reduced by them fast enough. It is my understanding that glycolysis is like a machine gun. Though ATP yield is not high per glucose molecule, glycolysis can fire off ATP so fast that it is kinda unsustainable.
Thanks for the explanation !!! I sell a probiotic that produces only L-positive lactate and was wondering if you have done any videos on L-positive lactate vs D-negative lactate?
Love the content!
Very good video, thank you! Helped me clarify quite a bit.
Could someone please just answer one question though, what exactly is lactic Acid then?
Lactate is the pyruvate+H ion but what is lactic acid?
Lactate is not Pyruvate + H. He misspoke. Pyruvate + H would have been Pyruvic acid. Lactate is the reduced form of Pyruvate from the reaction: Pyruvate + NADH + H+ ----> Lactate + NAD+. Lactate is the conjugate base of Lactic acid, so a Lactate + H.
I'm stressed out, got my bioenergetics final exam in a day. If I pass it'll be because of you.
Is there a way to relieve muscle soreness and tension without taking anything synthetic
I have tried everything for TMJ
Theoretically speaking, what could cause a steap decrease in lactate threshold? I have been in really good shape over that past few years but have suffered a preceived decrease associated with an increase in inflammation. I beleive that this inflammation is contributing to nutrient deficiencies that, in turn, are shifting my metabolism from VERY flexible towards needing much more carbohydrates.
Plz make video on energy system for climbing rope, and how to train which training method to increase anaerobic endurance.
Is the heart rate related by some mathematical equation to the threshold? I see 155 for the runner on your video. I am just confused between VO2 max and threshold and Heart Rate on why we can not find a clear scientific equation that relates them (just like your perfect explanation for Lactate using Chemistry).
I latic acid
Thanks for the amazing video
Thanks for watching
@@TheMovementSystem what other quals do you have or can anyone just make "educational channels"
Do sodium bicarbonate capsules work to lower lactic acid?
Super. In 21km run do u recommend gels??
That's typically a distance where you would see benefits from intra workout nutrition such as a gel or sport drink
That was a great video
Thank you
I think that a little clarification is needed.
You say that lactate is being produced at the same time as hydrogen ions and that lactate accepts a hydrogen ion.
However in the video “Lactic acid doesn’t cause muscle burn” you spell out that pyruvate+hydrogen ions = lactate.
Is lactate formed by pyruvate combining with hydrogen ions or does lactate attach to hydrogen ions in performing a clearance function?
As far as i understand:
1. Pyruvate ->
2. lactate dehydrogenase (adding a total of 2 H+ molecules to pyruvate)
(1 H+ from the NADH: co factor in this reaction and another 1 H+ molecule from …. Somewhere 😅)
= Lactate
@@dragonassassins1 Thank you for the clarification.
@@petermercadante630 Another clarification...It isn't two H+ being added to Pyruvate. Any dehydrogenase enzyme is "reducing" a molecule. That refers to giving that molecule electrons. H+ does not have any electrons, it's only a proton. NADH is giving two electrons to Pyruvate to reduce it while also giving it the Hydrogen atom. H+ comes from the surrounding acidity that always exists in the cell. In biology, H+ does not actually exist freely, it's understood to be H3O+ (Hydronium ion). So you can understand a Lactate anion as Pyruvate with two extra electrons and two extra protons.
@@Radjehuty Thank you contributing to this issue again. It is difficult to follow without the relevant scientific background but even to someone like me who does not have that background it seems that the science is not settled.
When reading below please understand that I am just trying to summarise what I have read and am not trying to explain a process about which I know little. Hopefully I have not misstated their views.
To summarise the points presented in this video:
1. Pyruvate “accepts” a hydrogen ion and forms lactate.
2. Hydrogen ions come from ATP hydrolysis which causes the PH level in the blood to drop causing acidosis.
3. Lactate buffers hydrogen ions out of the blood.
4. Lactate is produced at the same time as hydrogen ions but is a separate process.
Andy Galpin has a well-received video online entitled “What lactate is and what it actually does” in which he says that pyruvate “attaches” to a hydrogen molecule to form lactate so that lactate may be viewed as pyruvate holding onto a hydrogen molecule.
So they both seem fairly consistent in their description of what constitutes lactate. As an aside I note that you refer to “lactic acid” in the comments below, but these authors do not.
In the Catalyst University video presentation “What is Lactate and Lactic Acid”, the author says that:
1. In conversion from pyruvate to lactate the lactate is already ionised so that there is no H+ to dissociate.
2. The H ions come from the “strong ion difference,”
3. This means that the H+ ions increase to counterbalance the negative charge from lactate and maintain plasma electro neutrality.
Just to add to the confusion there is an online interview of Professor George Brooks well known for his work on lactate in which he states:
1.The body does not make lactic acid,
2. The end stage of glycolysis is pyruvate or lactate. He seems to suggest an “either” “or” which is contrary to all I’ve read about glycolysis. Attia seems surprised but lets it go. It is possible that Brooks was sidetracked or did not express that properly or that might be his actual view.
3. More controversially he asserted that lactate enters the mitochondria which Attia does say is contrary to everything he has learned and read.
You say that lactate converts to lactic acid but one of the world's leading authorities (as do most others) seems to be against you. On what do you rely upon in support?
Long distance triathlete here. I have no science knowledge but I find that when I urinate that my muscles regroup when strained. Not sure if that helps with getting rid of lactate
How Can you clearance lactate after a work out?
“Most likely muscle tears”… this is similar to Dr Andrew Huberman’s to the same topic. He stated “most likely due to calcium movement”. He did state some was due to muscle tears however it seems to me this is a bit of a mystery. Thanks for the chemical breakdown process. This helps a great deal
Chance you could explain Beta Alanine effects on this topic
The chemistry is a bit off. Once the lactate anion accepts the hydrogen ion, it is indeed called Lactic Acid. Lactate is the conjugate base. It's no different from any other acid-base reaction. Ammonia is a base and when it accepts a hydrogen, it becomes the Ammonium cation, its conjugate acid. Lactic acid can become a problem for those who are going into liver failure, lactic acidosis. Yes lactate can help buffer against the acidity of anerobic respiration but only up to a point.
So how would you define lactic acid? Awesome channel btw!
I'm wondering the same!
I am wondering the same thing!
lactate + hydrogen ions = lactic acid
@@bangnikabang6501 but its not actually acidic?
@@axelh5775 it is, as it’s an acid
smash the like button for lactate! clap for lactate
Hi sir I am from India my son is 2 and half years by birth elivated lactatic acid IEM after GCMS REPORT how is life sir please tell me what about
one of my strong athlete suffers muscle fatigue , how to avoid this problem?
…there is no such thing as a lactic acid burn…it’s the lowering of pH ( hydrogen ions )..of the localized area…which lowers O2 to the nerves…almost like the pain of neuropathy…whereas lactate ( base ) is used in the CORI Cycle … his explanation is excellent…
Amazing 🎉
How would you explain resting values of ~ 1 mmol/l ? Clearly, there is oxygen available...
Yes there’s oxygen available at rest but some muscle fibers are just very glycolytic and primarily produce lactate due to very low mitochondria. There are probably other reasons as well that I’m not aware of
@@TheMovementSystem Yes, lactate is a fuel and there is a tendency that lactate flows from glycolytic to oxidative fibres, eg heart muscle (lactate shuttle theory). But the point is, in exercise lack of oxygen is not required that pyruvate converts to lactate - the amount of lactate produced is a function of glycolysis.
so if your type 1 muscles are bigger, does that mean they can use more lactate and clear it fasteR?
Sort of. That also has to do with enzyme levels
@@TheMovementSystem So say I'm a cyclist and I build some serious muscle in my upper body. (All else being equal) I would be able to clear lactate faster but the acidity in my blood isn't going to be lower than before? So theoretically, I would have to stop at the same effort, but my lactate levels would be lower? :D
Or, could that pyruvate be 'freed' in other muscles and then be used again to buffer protons?
@@MrMattie725Those muscles consuming the lactate will still need oxygen to liberate the hydrogen ion so your capacity to clear the lactic acid is still going to be determined by your maximum oxygen uptake i.e VO2 max 👍
Thanks 🙏🏾
With that much LACTATE RBCs are gonna go crazy
Hmm.. I don't think he explained what lactic acid & its role is, how is it differ from lactate & what forms lactic acid. Or did I miss it totally?
great video
Is lactate responsible for throwing up or going to the bathroom
How does the brain clear the lactate out of muscles?
It is oxidized. Any oxidative tissue such as type 1 muscle fibers, cardiac muscle, or brain tissue can oxidize it.
If the role of lactate is actually buffering the H+, which sounds like a good thing, why is the accumulating lactate in the body actually limit the performance? Great video BTW!
Why do you think accumulating lactate limits performance? In fact I think metabolic acidosis is what is likely limiting performance and lactic acid is just building up at the same time
@@TheMovementSystem In the video you say it is wrong to refer to lactate as lactic acid and yet use that term in the reply.
Lactate's purpose isn't to buffer the system. Yes it does indeed help buffer, but its main purpose is to convert the NADH you're generating in glycolysis back to NAD+ to allow glycolysis to continue. Aerobic respiration has a maximum capacity and excess ATP and NADH will shut down the TCA cycle shunting pyruvate to lactate production shifting NADH back to NAD+. The liver must deal with Lactate though because when it buffers the acidity, it converts itself to its acidic form. If the liver fails, lactic acidosis can happen. The liver just performs gluconeogenesis with the lactic acid to give muscles glucose back.
I just wanted to learn how to lactate...
Is there proof of the existence of lactic acid? I don't mean lactate, i mean lactic acid
How can anyone think lactic acid doesn't exist? It's just the conjugate of Lactate. If Lactate performs its job as a buffer, then by definition it becomes an acid.
?????? Totally not confusing at all.....
Explain lactate shuttle
❤🎉🎉🎉
GOD is so beyond amazing. HE loves you all ❤️✝️
WAY too complex
ATP hydrolysis produce phosphate, not phosphoric acid. No proton is produced.
????? wtf - you havent explained the difference at all. You in detail explained lactate then used it synonymous with lactic acid later on. misleading title
Be grateful and grow up
@@curly_wurly_7219 be grateful for what. A misleading title ? And my time wasted. Seems like you have zero to input here so perhaps take your own advice and grow up. 🛎️ end
@@curly_wurly_7219 did you even watch the video ? Tell you what smart ass hit me with the time stamp with when he explains the difference. Reread the title of the video. It’s not called “what is lactic acid “ which is all that’s explained. Come on go get your big boy pants on and explain to me why my comment is not justified ?? I will be waiting. See when you can’t because what I said is right , then get back into your box and stfu 🤫 !!
@@curly_wurly_7219you enjoying your time back in your box !
…to be truthful, it’s complex chemistry …and I understand why you don’t understand his precise explanation…ignore the replies who think you’re just a troll…
#timpool #alexjones #russellbrand #ye #projectveritas #nfl #joerogan #ufc #wwe
#elonmusk #nascar #5g #cockatiels #ai
Why can't my exercise phys profs explain things like this 🥲