Hope you found this video helpful! Let me know below. You can subscribe to my channel here th-cam.com/users/thehonestchannel You'll find more advice and info from me around how to age well on my website www.honest.scot And you can listen to The Honest Channel on the go via TH-cam Music or your favorite podcast platform!
My husband and I have taken Nmn for 1 year now and we have the same good experiences. Most of all, our skin improved drastically and we have no need for skincare products. We are 53 and 54 years Old.
I often wonder if NMN has had a similar effect on my skin. It's a difficult one to judge as, in my case, there could be other factors at play. Great to hear you've both had such a good experience though.
What brand are you using? Thank you so much for sharing as I'm just learning about NMN and am excited about how it will assist in addressing a skin condition I have.
I'm an 82 year old and have been taking 300 mg of NMN for the past 30 days. I am having less trouble keeping my weight at 110-115 .and have a good energy level . My exercise routine at the gym is 2 days of hour long resistance training and 2 days of 1 hour stretching exercises. I also take Spermadine 20mg daily in wheat germ plus 1000mg of liquid B12 daily. I feel well and energetic plus I sleep 7-8 hours every night. I'm planning on continuing my whole plant based diet as it seems to be working for me. Thank you for your video and I will stay in touch. Also, my doctor is fully aware of my lifestyle and supplements and continues to encourage me.
@@DebbieTDP Sorry you have succumbed to a false conspiracy theory narrative. All you need to do is read the science. I take no medicine at 82 except for a stroke before I went plant based. Follow the science my dear not the conspiracy theorists. Also I must add that if you search the scientific literature there is plenty of complete protein in plants. in case you were not aware.and there are many olympians on a plant based diet.
I was being assessed for ALS MND Motor Neuron Disease, I used mega dosing of B3 Niacin and B3 Nicotinamide to deal with my depression, my fatigue was off the charts with muscle wasting.. My depression was under control but at the same time I started taking ASEA Redox Signalling Molecules and after 2 weeks I stopped the mega dosing as my depression was lifted, my energy increased, running and power walking and am now working 6 days a fortnight, seeing muscle tone increased, my left hand still has spasticity but is increasing in strength and my right arm is improving also.. Praise God as I only started on the 7th August last month 2024 🙏 .. I always believed that there is nothing impossible with God. Such an answer to prayer, praying many more discover this supplement that will improve you life and health 🙏
Stansfield is a junior doctor who confuses clinical studies with personal effects and apparent personal animosity to Dr. Sinclair. I am 80 and have been taking NMN (~1gm) with TMG (2 gm) for 6 years. I walk 3-10 miles a day, and do some weight baring exercises. I have reduced carbohydrates and increased protein. I am convinced the NMN has been effective in supporting my activity. I still do very complex consulting in data analysis. I prefer to look out the window to see if it is raining than listen to a expert weatherperson! I agree with your approach and applaud your openness in discussing your experience.
I've been taking NMN for 6 months, starting at 250 gms then 500 gms. Added TMG about 2 months ago. I'm 70, still working 7 days a week, and still remember the early days of NMN where I'd have periods of buzzing round my shop feeling like I was in my 30s, though not with the same stamina. Now that's the new normal. When I took NMN at night I had a truly awful week of sleep because my brain just wouldn't switch off, so that was a negative proof if you like. Thanks for this honest review ~ I'll make my own experiment by splitting my dose into morning and afternoon - now I think about it, that seems an obvious thing to do ! I also eat in a 6 to 8 hour window each day, and started a carnivore diet more recently to fix some gut issues so it's hard now to isolate the benefits, but I do feel NMN has been a very positive influence.
@@markmartin6436 No, that should be okay. Dr. D. Sinclair takes 1 gram in the morning with joghurt. I take it with water. Sinclair said that natural NAD levels in your body underly a circadian rythmn and spike in the morning which is why he takes it in the morning. Taking it in the evening might make it harder to sleep.
Thanks I have tried NMN and I wasn’t sure if I felt a difference but listening to your podcast has helped. I’m 75 years old walk 2 to 3 miles every day and lift weights 5‘,5“ and weigh 120. Sometimes I’m embarrassed to tell people my age because they don’t believe me and that’s a good thing!
I have never heard of NMN until today. i have been looking for something to help damage cells in the prostrate, as I have BPH. Since you mentioned your father’s prostrate problem got better, i wonder if this would work for me. Loved all the information from this video. This could be a game changer for me. I am a male at 66 years old and looking out of the box.
@@rudylopez692Take a look at the sulforaphane studies on prostate cancer. You can incorporate this, along with INTRACELLULAR glutathione therapy. These protocols reverse prostate issues, and promote apoptosis even in cancer stemcells.
Thank you for such a detailed account of both your experience and that of your parents. Glad you have seen such great results so far with our pure ingredients.
Dear Honest Channel, i have watched your first video also with Dr. Elena Seranova. Really in this video you look younger and more healthy. I think it works on you. I have started using NMN, TMG and Berberine also last month.
Thank you. It's such an interesting supplement and I'm sure there will be many more studies to come and more scientific debate but we all feel we've benefited from taking it.
I've been taking NMN, TMG and berberine for over 12 months now. My waist size has dropped from 28 inches to 27 inches and my body tone has definitely improved. However, I don't feel any different. I've always has no health issue. I'm now 45yo. I have recently started taking Creatine and Taurine, and have always taken Cod Liver Oil. I weight train only about 10 minutes, but on a daily basis. Also, I have started being able to lift heavier weights since starting on Creatine.
Thanks for keeping us updated on your family's experience w/ NMN. I stopped taking it about 6-8 weeks ago and feel less fit and energized. I am planning to bring it back into my supplement routine.
I remember you saying when I interviewed Dr Brad that you'd stopped taking it. Really interesting that you've had an energy dip as a result. I might switch to NR after I finish my current batch of NMN to see how I feel with that, but the weight loss and increased energy mean I'm unlikely to walk away completely!
Thanks for the personal trial with MNM! For NAD boosting, I've been taking liposomal NMN at 500mg/day along with 50mg niacinamide with 500 mg DMG for over a year. I also lift weights 4 times a week and do treadmill HiIt twice a week. I've always exercised, so I know it produces many benefits including NAD. But now, I weight train at the end of my fasting window in a fasted state... which is hard but makes me feel AMAZING! I also do intermittent fasting (17/7) and do 48 hour fasts every 10 weeks. So what does all this mean? Well at 67, I am still squatting 450 lbs and plan to set a world record by age 70 as the record is only 365lbs for this age and my 198 weight range. My theory is simple. Keep the body at a state that still is in the "REPRODUCTION CAPABLE" state. This extends quality of life. "DON'T LET THE OLD MAN IN!"😊
@geoffbendel9467 The body is a complex system and everybody is unique. So go to an integrative health professional and start with healthy oral hygiene. Consider Dr. Berg's protocol. .. Hydrogen peroxide mouth rinse. Next, work on healthy gut. Most people have LEAKY GUT . due to all the pesticides. Consider Gut Restore by Ion and organic bone broth. I also take 5 grams glutamine with grass fed colostrum and kefir. Take this all together prior to breaking your fast before the first meal. Once your gut is healthy, you can start looking at other supplements. To boost glutathione, I take 1000 mg NAC and 5000 mg collagen (contains 4400 mg glycine)
@geoffbendel9467 I've been doing Amino Acid therapy... taking 2 gm taurine, 2.8 gm beta alanine (different times) 3 gm HMB (post workout) and just added 2.8 gm creatine. However, I switched my NMN to NMNH... Doublewood brand due to the far greater NAD+ boosting for longer periods. I also am trying molecular Hydrogen by Dr Mercola. I feel 25 again!
i have been taking NMN and also same about losing weight with minimal effort, also back to weight of my 20’s and i am 51. i stopped taking it for about a week and noticed it immediately. I only get exercise from yard work, and i have reduced the amount of carbs in my diet while boosting protein intake. i take a liposomal version of; MNM, Berberine, TMG and for me the liposomal version showed a much more noticeable positive difference everywhere except my wallet as it is a little more costly. I don’t regret the money i have invested in the last 4 months, in fact taking supplements my entire life, this has been the most effective investment i have made over the years.
@@scottbucc renue by science lipo nmn, the berberine code age, and apigenin code age. you have to take apigenin as is suppressed the cd38 protein that will consume any excess created nad from the nmn uptake. if you don’t take apigenin you will not see the benefits. my guess is the cd38 exist to consume any perceived “excess or extra energy that might be used by a cancer cell or zombie cells” So to prevent from feeding bad cells since i am 51, i did three months of liposomal fisetin benign a brand, 1200 mg for three days, every 28 days. basically mimicking a woman’s menstrual cycle to in an attempt purge the bad cells senescent or precancerous as i didn’t want to boost their nad levels. you will experience brains fog, at-least i did by day two of the fisetin uptake. but you only take it for three days then stop wait 28 days and start again. i also increased my uptake liposomal resveratrol during those three days, and liposomal curcumin code age. that was to encourage the zombie cells and precancerous cells into atophagy. i started to hit a plateau two weeks ago, so started full carnivore. i thought my energy levels couldn’t get better. Wow. a steak, 6 eggs and water, little butter and avocado oil one meal a day. i can’t believe the improvement. i also take NAC Glycine milkthistle 1000 mg each. i have a chest cold currently and worked 9 hours straight cleaning a rural lot, woke up this morning 6 hours of sleep feeling great.
@@MrRESolutions sorry for the late reply i am not so good at social media and checking replies etc. i hope the information i posted helps. i got my start reading dr laura kaufmann two books, the kaufmann protocol aging solutions, the kaufmann protocol why we age and how to stop it. i thank God everyday i saw an interview with her on modern lifespan channel. it has changed my life, inwas debilitated by gout in my hands knees feet now all gone after 3 months. i also read nathan s bryan phd, functional nitric oxide nutrition and take his N1O1 nitric oxide lozenges. i focus in less mouth breathing whenever i can. i take the seed synbiotic, after reading william davis md, book, super gut. i did take one bottle of restor flora pd about month two for 20 days. i stopped using fluoride products and switched to tooth paste that uses xylitol. it works my gums never bleed, almost no plaque build up and i had bad dental habits because i never liked the fluoride toothpaste. i quit using mouth wash that kills bacteria because it was killing the good bacteria in my mouth. i share this because i did all of these th8ngs at the same time, 90 days after starting i have seen a complete turn around, lost 30 lbs, never felt hungry, thanks to the liposomal berberine really killed my sugar cravings. allowed me to ween off that sugar addiction. now going full carnivore i have no hunger, i have an appetite same time each day before i eat my steak and eggs but no cravings for snacks which i cut out completely by month 2. i lost 4 inches in my waist and had to buy new shorts. and because i am older i take nattokinase by wright life. i no longer need the blood pressure meds i have been taking for 8 years.(losartan). libido is also like a 20 year old. it did cost money, but you can either pay the health stores now, the doctor twice as much later or the mortician. the books were important for me to understand why this concept of supplementation would work. i had to have the details, i am not as good at regurgitating them, but these doctors and people posting videos about increasing lifespan have completely changed my life for the better. Happy New Year btw. i hope you find what you are looking for on your health journey this 2024.
As a 74 y.o. male with COPD I decided to try NAC + Glycine ( 1 Gram of each) around 5 months ago. Within 2 weeks of starting I found I had better oxygen levels which permitted faster walking and longer duration. As a byproduct to the improved oxygen circulation levels my cold feet are no longer cold, and my hair apprears to be getting darker. Tyhe only word of warning is to ensure you get good quality NAC from areputable company as there are many fakes around this unregulated industry. From Australia.
What a beautiful presentation so clear and honest. Personally, I take 500mg NMN, TMG, and resveratrol, sincerely I have never clearly understood the effects of these supplements, but I try to follow the results of research in this area, and I believe that we will evolve towards more conclusive results. I think research should focus more on why NAD levels decrease with age, rather than looking for strategies to increase them.
Hey Clare, another great video. I totally agree with the need for more informative investigations into the use and beneficial claims made about MNM , NR and other precursor only supplements. The discrepancies in your NAD+ blood test levels is no surprise. Accurate and reliable at home consumer NAD testing is still a long way off. The reason being - the NAD coenzyme is extremely unstable and it degrades really quickly. The only way you can accurately measure NAD is through a process call mass-spectrometry and is used after any samples of blood are immediately placed on ice to prevent degradation. I do agree precursor-only NAD boosters (like NMN and NR) do increase a person’s NAD levels but “lack of available precursor material” is not the reason for our declining levels of NAD These pre-cursor only NAD boosters do not address the root cause of NAD decline as we get older. There is also growing and concerning evidence over the use of NMN in isolation and the resulting short and long term impact of methyl donor depletion hence why one of the products you and your dad were using also needed TMG. An effective and efficient NAD supplement needs to have a whole-systems approach that is backed by real clinical evidence in the form of human trials and addresses the root cause of NAD decline. These products do exist. Keep up the awesome content.
I'm 66 and have been taking NMN for about 16 months now. I immediately felt results on day one. My energy levels increased, I no longer felt drowsy in the afternoon after lunch and I just felt better overall. I also lost 40 pounds over a five month period but I'm not sure how much of a role NMN played as I changed my diet as well. Before starting NMN I had decided to get in better shape also and started doing one thing I really love, day hikes. I live at 7000 feet in the Rocky Mountains and the hikes ranged from that altitude up to over 11,000 feet. At first I could only walk about three miles without feeling exhausted with minimal improvement until I started taking NMN. Almost immediately, my range improved to over four miles with another leap to over six without feeling beat. Now, I can do over twelve miles while reaching the high altitudes I mentioned earlier and, while tired, I'm not just totally worked. I also believe my pace is on par with what I could do in my thirties. NMN has had a significant effect on my life despite what Brad Stanfield says. I've come to the conclusion that he will take the opposite stance on just about anything that Dr. Sinclair and others do just to feed his own ego. I stopped following his TH-cam channel months ago.
I also take what Dr. Brad Stanfield says with a grain of salt. But it's good to have a devil's advocate in the longevity community. I like to consider the other side, too. That said, I'm also very grateful to NMN for boosting my own energy levels.
NMN and Homocysteine: NMN may theoretically increase homocysteine levels because it increases the consumption of S-Adenosylmethionine (SAMe), which is needed for homocysteine methylation. This could raise the risk of cardiovascular diseases. To counteract this, the intake of TMG (Trimethylglycine) is often recommended to balance homocysteine levels. TMG and TMAO: However, TMG intake can increase the production of Trimethylamine-N-oxide (TMAO) in some individuals, which is also linked to an increased risk of cardiovascular diseases. These interactions between NMN, TMG, and TMAO are complex and require further research. It's important to use supplements like NMN and TMG under expert supervision and after careful consideration of potential risks. Regular blood tests can help monitor for any adverse effects.
My husband and I have been taking NMN with TMG for over 2 years now and feel great with similar results to you. We are both in our early 70s and feel so fortunate to be able to take it.
Thank you. This is the first video of yours I have watched and found it informative. I do dowsing and muscle testing. The first few min of the video I was questioning the use of NMN for myself and others and kept getting a No. I thought that was odd. Then after you mentioned it was suggested to take NMN with TMG, I questioned again about taking NMN but with TMG for myself and others and then got a Yes. So I found that interesting. I am taking many supplements and superfoods now however I will want to save this video and begin an NMN + TMG and possibly Berberine at some point when the budget allows.
Is it filters? I think we should know because we use her as a barometer and piece of anecdotal evidence on how nmn might work for women our age. I would sincerely hope that she would say, 'thanks, may also be the filter I am using', otherwise it it very disingenuous.
Hi Claire thanks for the update. I have been taking NR and TMG (250 mgr) for a year now and have experienced the same benefits as you describe . The difference being the much lower price tag. But then again you probably get your NMN for free.
That's really good to hear. I got the initial batch free but am buying my own now. I may well switch to NR for a while to see how I go. Did you experience the weightloss too?
Really informative and honest thank you, and you've actually run your own trials, not just recycling others' viewpoints! I was talking to my brother (37) about NMN a few weeks ago and unbeknownst to me he'd been taking it for a while (500s) and does feel more alert from it. I'm 6 years older than my brother and about to place an order to try it myself. I'm hoping it will improve my sleep and boost my energy. Thanks for the great vid.
I am 76+ have been taking NMN for the same period of time as yourselves. I did not find an initial increase in energy as many in the U.S. reported. What I did find was that pains in my feet, particularly big toes, that had been there nearly 10 years and were affecting my ability to walk with no medical explantion, had dissapeared and after a month that the 'liver spots' on my hands were fading. Now though I do feel better, I stand more upright and I do not fall asleep all the time. I also take resveratrol and keep up my input of flavinoids though red/dark fruit and veg.
great vid, i just started taking it, one week roughly, not much diference but, i do feel happier, and my skin does feel softer, havent lost any weight because i lost all that when i became a carnivour, and slightly more clear headed ... haven't grown any extra hair yet, but the new third arm is a bonus ;)
A few months ago, I start taking GlyNAC, NMN, and TMG. I only did NMN for a couple months and then swapped it out for Niacin because NMN was too expensive. I've been feeling the best I've felt in a while, and quickly somehow lost 15 pounds barely trying. I don't get tired half as easy when doing any kind of exercise anymore. Just a word of warning to others, if you decide to use Niacin: in the large doses you need to take to affect NAD levels, it causes an intense flushing effect on your skin. It's really itchy, and your skin can feel really hot. It lasts 10-15 minutes, and it's not in any way dangerous, but the first time it can be a little scary if you're not expecting it. Some say that flushing effect also has a benefit to our skin by circulating blood through it.
@@jdxx59 If it's the slow release stuff you're talking about, you can get liver damage. I personally don't mind the flush. I feel like it's good for the skin.
Wow this is so comprehensive! I’ve just had some more delivered from Youth and Earth. Now I’m wondering if it’s worth my money from here on in, having watched all this…. I can’t say I’ve noticed a marked improvement in either energy/sleep or pain reduction, but maybe if I STOP taking it I’ll take a dive. If this happens I’ll let you know, cos then we’ll know it was working! X
I love your vids; you bring a journalistic quality to the research of products, devices and practices. BTW: Anecdotal observation of course, but your skin and hair have improved greatly since your early vids. You are looking vibrant and beautiful. ❤
Ive been taking Vitamin B3 derivatives (NMN, NR) and now Liposomal NAD and B3 for 4 years. The energy and health benefits seem obvious to me. I can walk up to 8km per day and never feel tired. i sleep well and have lost 8kg since 2020. I first took it for recovery from Post viral fatigue (Covid) and it only took 2 weeks to take effect after being totally listless for 3 months prior. My latest regime is L-NAD (800mg) in the morning and B3 (500mg) at night, plus TMG (500mg) also in the morning. I am 58. I cannot recommend NAD boosting enough!
I've been taking liposomal NAD+ with trans Resveratrol 800 mg. I always know when something is beneficial when i stop taking it. It does help with my sleep, allergies, energy, and my skin looks much better😊 i will continue to take it.
Good to hear you’ve found a regimen that’s working for you. I agree, it’s often when you stop taking something that you realize it was actually making a positive difference.
If your Mother's B12 Injections were in the form of Methyl Cobalamin (likely)... that would significantly boost her system's Methylation efficiency. Low levels of AVAILABLE Methyl Groups is well known to limit lots of processes that require Methylation of precursor compounds...as is the case with NAD.
Don't underestimate TMG - it is sold as helping with methylation, but it is also a good source of glycine and some people think that glycine supplementation can help you hit healthy glutathione and collagen levels. This is pure speculation, but I wonder if we need a good glycine + taurine to Methionine + BCAA ratio analogous to the Omega 3/Omega 6 ratio.
Thanks you Claire for this video. Using NMN as well for almost a year. Noticed the results very quickly in terms of the weight lifting at the gym and feel more energised (even though it didn’t solve some other challenges). How about interviewing Marcel from the TH-cam channel The Pulse? He’s sharing his NMN journey for quite some time with amazing results (in combination with other supplements and exercising, mainly playing tennis. You will love his story. Thumbs up and keep up the great work!
Hello! We stopped taking the berberine after a couple of months when we moved to the donotage powder and TMG capsules. Should have made that clearer. The weightloss became most obvious around 3 months in.
@@thehonestchannelI’m a new subscriber and really enjoyed your series on NMN. I’ve been sitting on the fence about NMN because of that controversial article on NR and its effect on cancerous tumors. I was happy to hear you and Dr. Elena addressed this issue! Question: So when you switched to Do Not Age’s NMN powder, did you discontinue taking TMG & Berberine? I’ve taken Berberine before with no discernible difference.
Thank you. The discussion was appreciated and helpful. (a 77year old Australian). I haven't measured my quantities precisely relying on a combination of diet and an exercise regime and in general I feel very well. This has been over an 18 to 24month time period. As well my supplement' s being D3 , K2, C , D, B12, Zinc and Magnesium along with an occasional dose of Ivermectin.
Hi I’m in New Zealand how do you obtain and take ivermectin please? Or any videos you could link regarding it? I have rosacea and I believe ivermectin is effective against the demodex mite
Hi,also in Aussie,I like you take the same vitamins,however would like to know where you get the ivermectin from…I do have some some in a paste form but never taken it…🙏🌻
@dimcbride8969 hi, I had persistent rosacea. I was soon diagnosed with hashimoto's thyroiditis. Doctor prescribed levothyroxine and vitamin D. My rosacea has been gone completely for 4 years now. I'm not saying that you will be the same. But maybe worth getting your thyroid and vitamin D levels checked. Best wishes
Thanks for your very informative Channel! I am 70 next month, have remained active in the gym for a good 25 years. I am at the same weight I was in high school. I do try to eat carbs only once a day if any at all. I typically fast 16-18 hours between my eating time. Until I feel I am beginning to fall apart I will stay with my usual routine. Thanks!
the fasting does nothing - since you are not a mouse..., it just preventys you from adding size.... so your weight is the same, but your muscle has been decreasing since you eat all your foods at once, an dthen stopping to eat....
Very interesting video, thanks for bringing us your results. Being a bit of a geek, I did a very deep dive into NMN myself and this lead me to Dr Nicola Conlon's research on NMN and her company Nuchido. She's a British scientist who has created a next generation NMN supplement which is I believe one of the very few supplements to have undergone a rigorous double blind placebo clinical trial with published results. Her product aims to address the root causes of why our NAD levels decrease with age and I learnt a lot more about NAD from watching some of her presentations. I've been taking her companies supplement myself for 3 months now with very positive results so far, and in order to verify my subjective observations, I've also done a glycan age test prior to starting the supplement and will follow up with a repeat test in 6 months to see whether it has indeed lowered my biological age in any meaningful way. Anyway, I just wanted to bring this to your attention as I really think this will add a lot of clarity to the whole NMN debate.
Definitely worth watching some of her presentations on NAD cellular biology on TH-cam. Also, in my research I found that researchers don't put much stock in the postal NAD blood testing kits as the active NAD degrades so quickly outside the body. That's why it's better to do a test like the Glycan age test and use this as a proxy rather than testing for NAD itself as this needs to be done in a laboratory. Although I stand to be corrected if I'm wrong as I'm not a scientist, just a guy doing some research online!
Hi, I just stumbled upon your channel because I just received my order of NMN 9000 Ultra from Allbe. I should've researched before ordering, but this resonated so much and I couldn't wait to start taking NMN. I'm approaching 40 yrs in a couple months and I have been combating RRMS for almost 13 years. And well it's never too early to give the body what it has very likely been missing for... most of its time on earth. I hope that I didn't do a bad thing by not first consulting my neurologist. In my defense tho the guy, without even stopping to consider, advised me to take the recent vakscene debacle.rotflmao. My discerning spirit would not allow me to comply. 🎉 I'll compare prices going forward after I finish my 3 bottle subscription. So in 6 months.
I’ve been taking NMN for six months, though it was hard to find and I had to have it shipped in from Canada. I started taking GlyNAC about four months ago, but it started causing diarrhea after about a month, so I have had to cut the dose in half, then half again! I started taking TMG two months ago, along with Creatine. So far the only positive effect has been that I have stopped losing muscle strength, and have been able to increase my weight workouts back up to five days per week (I had dropped down to three workouts per week, on my doctor’s advice). Other than that, I haven’t noticed any improvements in my appearance or health. I did start suffering from cold sweats at night beginning about one month into taking NMN. The only thing that has help my arthritis (both osteoarthritis and ankylosing spondylitis, which is in the rheumatoid spectrum) has been a large dose of MSM twice a day. I am no longer able to take the biologic drugs that had previously worked so well, due to the detrimental effects on my immune system.
Hi Clare, thanks for sharing your NMN videos and results for you and your parents. I'd be interested to learn how things have gone for you all whilst on NMN both for myself and my elderly Mother. Thanks🌈
I bought a five year supply of NMN before FDA banned it in U.S. It’s vacuum sealed with dryer packs kept in a deep freezer so it doesn’t deteriorate. I’m 65 and take it daily. NMN seems to help my general health.
I have tried NMN and NR, I gave up both for just plain Nicotinamide. I take the plain Nicotinamide because the others are costly supplements which get broken down to plain Nicotinamide because of digestion. The digestion process breaks down the NMN and NR but this does not reduce their effectiveness as obviously they still do have an effect after your body reassembles them. The basis of my theory comes from research on skin cancer here in NSW Australia. .Oral Nicotinamide Prevents Common Skin Cancers so to me that means that the same mechanism that is aiding old people in maintaining higher NAD levels is the same whether you are taking plain Nicotinamide or NMN / NR. David Sinclair has admitted that plain nicotinamide is effective in raising NAD levels. I also eat a Vegan diet which has remarkably good effects on my health as well and David Sinclair has admitted he does too.
Thank you. I always feel that when we don't have a huge amount of evidence for so many of the emerging 'longevity supplements' and products we need to be cautious.
Thanks Clare, for this great follow-up to your NMN testing. It would be very interesting to see blood test results from an independent lab with no involvement from donotage, as a comparison.
The labs they use aren't owned by donotage so in that sense are independent, but it would definitely be interesting to do another test with an unrelated lab.
I am 70, frequent resistance training enthusiast as well as a hiker. I have two blocked arteries and CKD Stage 3A which has improved by eliminating fried foods and cordyceps. Started 300 mg NMN per day since June 24. Two observations: (1) improved strength training and recovery. ( increased libido. Other: Sleep has not improved. Sometimes I train too hard and need to nap right after workouts and protein supplementation.
I think you said you were also taking Berberine - surely this is more likely to be why you have lost weight as it works like metformin and helps with metabolism and insulin resistance. ??! Many people who take berberine lose some weight as it's a bit of an appetite suppressant ??!
I'm at the stage of being tired earlier than usual I have been taking NMN BUT I WAS TAKING ANTIDOTE SHILLIJIT LIONSMAINE AND SEAMOSS 3 IN 1 I HAVE NOW STOPPED THE ANTIDOTE SHILLIJIT AND NOW I FEEL AS IM NOT GETTING THE FULL EFFECT I HAVE LOST A BIT OF WEIGHT MORE ENERGY MY ADHD HAS GOT BETTER MY PTSD HAS GOT BETTER PRETTY EXCITED FOR THE FUTURE BECAUSE I AINT BEEN TAKING NMN FOR THAT LONG THANKS FOR YOUR CONTENT
Hi Claire, tryptophan can also increase NAD and is much cheaper. I've just started so I have not noticed any changes in energy but I take it before bed and I have noticed it helps me sleep. 🙂
Very well researched impressive video. I am curious regarding your weight loss. DId you only take berberine for one month or the entire time? Berberine is associated with weight loss so I am curious if you only stayed with theNMN or also took berberine...Thanks!
We only took berberine for the first six weeks or so until we ran out of capsules. I should have been clearer about that in the video. There was so much to pack in!
I take berberine daily and have for at least a year. I have gained post menopausal weight around my midsection since starting bioidentical hormones. The berberine isn't helping me in this area.
I am 70 and have been taking 2 to 3 grams of NMN a day from DoNotAge for the past six months. My waist hasn't been so thin in nearly half a century. Am working out at the gym and stronger than ever before, jogging and milking cows on a kibbutz, very difficult work. My medical issues have nearly all disappeared. Through trial and error over decades I can definitely say that most of my results can be linked to NMN. Why don't they give at least a gram in human trials?
I open with the fact that I’m a sucker for gimmicks, I wanted to say thank you for the video, your delivery feels far more balanced than some other channels. I’m 57 and physically train everyday, I wanted to boost energy so I watched Brad regards Taurine and took 900grammes of the bat (I know, I am an idiot) this had a adverse effect and caused an allergic reaction which resulted in breathing issues. It turns out that Taurine will affect allergic asthmatics, if you do a piece on Taurine would you stick a note into warn people of the potential dangers. I will research the NMN and test the theory. Really great delivery, Many Thanks, J
I have to agree my own experience with NMN at age 66 is quite good. I have always been athletic cycling 8000 miles a year with 500,000' climbing but I was feeling more & more my age the last 3 years. Since taking NMN a gram a day for three months I am really happy with it & the results. As an aside I would like to say you yourself look very much better than your earlier video...Not that there was anything wrong with those videos which you showed clips of in this video but now in this video you clearly look healthier/younger more vibrant...It Shows! Thanks you for the video it was interesting & as I said echo's my own findings
FYI there's a huge quality difference in brand and manufacturer. Tony Robbins talked about it; they bought several off the shelf and tested them. Some contained no active ingredient whatsoever! Assuming not every company was trying to scam, NMN degrades quite fast. It's not super shelf-stable (not sure about NR). But that could be what happened with the stuff you bought.
@@BrianThrivesI took the brand mentioned in this video, codeage liposomal, and Thorne. These are the brands I trust and in general considered to be top quality you can get. Zero difference. Nothing at all. I get a lot more change from a simple vitamin c shot. This did absolutely nothing for me. Regret spending a fortune on this scam.
Resistance training has been shown to visibly improve skin quality so that would be a great place to start www.honest.scot/exercise/the-exercise-that-also-strengthens-your-skin/
Been on NMN for 2 years, felt the most benefits in the first few months, not so much afterwards but still taking it to be sure, yeah so maybe 3 month is all you need to reach optimal level.
I have recently started with intermittent fasting. I'm mostly following Mindy Pelz' IF advice. Still early stages with that so not much to report yet. (If IF gives you headaches then take a little salt with the water, is all I have so far). In general I think it's way too late to try and affect my life span. (I'm not sure I would want to anyway since I have very poor quality of life). But I take mineral and vitamin supplements, no tobacco/nicotine (ever) and very little alcohol, and I try to eat more veggies and fruit. I'm not particularly strict with my diet though, I eat sugar and less healthy foods sometimes.
I Just read your comment, it's sad you feel you don't have a great quality of life... I think the best we can do for ourselves is try to live a better life rather than a longer life, as a result we may get a few extra years... The reason I replies to your comment was to ask you if you heard of Red Light Therapy, if you're watching this kind of content on TH-cam then, i'm sure you have... Personally I believe that along with a sensible and healthy lifestyle it's probable one of the best things you can do for your body along with practising yoga and everything else in moderacion... It's very easy to get caught in the mindfield of suplements and the trouble is, a lot of them do absolutely nothing other than make those manufacturers and suppliers rich... and in most cases you need to be taking something else to make something else work... We are what we are, some people eat shite all their life, smoke a packets a Day and out live someone who had a healthier lifestyle, it is what it is... If you haven't already then get yourself a Red light device, I believe it's a game changer... If you need any help with that then let me know Regards Oh and IF, another game changer, definitely believe in the benefits of that...
I take NMN too, but I am going to switch to Rapamycin once we can easily get it. It has repeatedly been shown to reduce aging in humans, while NR and NMN have not.
I still take NMN despite no one having been able to replicate good effects in humans. Rapamycin, creatine: those have a lot of evidence backing them from my reading of Attia and others.
Yes, a lot of it is a płacibo effect but it does actually raise levels. It's not always a good thing. People abuse NMN and other NAD+ supplements because these companies sell it well. I've read so much research on NAD+ and although, it did have successful mice experiments, humans are not mice, but they also don't ever do their own research.
I, a retired physician, once got a patient from my older partner. He put her on about 10 meds, to which she unfavorably reacted. I took her off all meds and put her on 10 placebos. She did well. I checked on her after I left that practice. My former partner put her back on all 10 meds.
Interesting experience. Thanks for sharing. I've heard there are studies suggesting TMG potentially helps reduce white fat, increase brown fat, and may even maintain muscle mass while losing weight. Since you took both NMN and TMG together, I wonder if the TMG was more responsible for your body composition changes than the NMN. I'd be curious to see someone just try TMG and see what happens. There's a logical reason to take both together, but I wonder if it's obscuring which one is actually doing certain things.
Hi, thank you so much for all the information, I would like to know what brand or where I could found a secure source of NMN. I went on amazon and I found lots of brands. Thanks for your time.
Thank you for a truly balanced video and your honest personal experience. I was going to work my way up to 1.5 g of NMN but I find my own sweet spot is 750 mg with the same amount of TMG, split over two or three daily sublingual doses. In my 50s. Energy levels are up. I feel less creaky. And my greys are going away. I use Renue by Science. I plan to increase thedose in my 60s or 70s or when my body hints at it. On the other hand, I may taper down in the future if I exercise more.
46 years old and 1.5g nmn for years now. No bad side effects. I sleep better than i used to. Still strong in gym and seem to heal faster from cuts etc. I have been blood tested for nad i am smack in the middle of optimal so i am sticking to 1.5g with an open mind to going to 2g later in life.....
Additionally, the researchers found that in mice, 4PY triggered inflammation in the blood vessels. This inflammation can lead to damage, including atherosclerosis, or the buildup of plaque in the artery walls. The study was published Feb. 19 in the journal Nature Medicine. Lead researcher Stanley Hazen, M.D., says together the findings suggest that excess niacin is not just associated with an increased risk for heart disease but may also contribute to its development. The results could pave the way for treatments to reduce or prevent blood vessel inflammation, as well as diagnostic tools to help identify people who are getting too much niacin and may be at higher risk for a heart event, Hazen says
This is complete BS. Get prescribed Niacin FOR heart issues up until about 30ish years ago. Any “issue” with niacin is taking the niacin for present in NMN…which is the flush free version. The flush version is processed immediately. It is called nicotinic acid. The NMN niacin is Niacinamide or nicotinomide…these are NOT processed right away and get stored in the liver and can bullies up to toxic levels. Big pharma is engaged in a Full court press to discredit traditional niacin. If they wanted to prove it was not beneficial, they would run it 1:1 with statins and compare results. They have never done that, only paired with a statin versus just a statin. They concluded no benefit. Yet here we are, with heart disease as the number one killer in the US, even though we have these wonderful statins!
Follow the money. Eat right , exercise and Niacin. Supplements are just that. They supplement all of the aforementioned. We as consumers have bought into the idea of health in a bottle.
Hope you found this video helpful! Let me know below.
You can subscribe to my channel here th-cam.com/users/thehonestchannel
You'll find more advice and info from me around how to age well on my website www.honest.scot
And you can listen to The Honest Channel on the go via TH-cam Music or your favorite podcast platform!
My husband and I have taken Nmn for 1 year now and we have the same good experiences. Most of all, our skin improved drastically and we have no need for skincare products. We are 53 and 54 years Old.
I often wonder if NMN has had a similar effect on my skin. It's a difficult one to judge as, in my case, there could be other factors at play. Great to hear you've both had such a good experience though.
What brand are you using? Thank you so much for sharing as I'm just learning about NMN and am excited about how it will assist in addressing a skin condition I have.
Did you start exercising or change your diet ?
Did you take TMG with it ??
What brand?
I'm an 82 year old and have been taking 300 mg of NMN for the past 30 days. I am having less trouble keeping my weight at 110-115 .and have a good energy level . My exercise routine at the gym is 2 days of hour long resistance training and 2 days of 1 hour stretching exercises. I also take Spermadine 20mg daily in wheat germ plus 1000mg of liquid B12 daily. I feel well and energetic plus I sleep 7-8 hours every night. I'm planning on continuing my whole plant based diet as it seems to be working for me. Thank you for your video and I will stay in touch. Also, my doctor is fully aware of my lifestyle and supplements and continues to encourage me.
Sorry about the plant based choice. 😢
Not healthy at all, it's the agenda for depopulation.
@@DebbieTDP Sorry you have succumbed to a false conspiracy theory narrative. All you need to do is read the science. I take no medicine at 82 except for a stroke before I went plant based. Follow the science my dear not the conspiracy theorists. Also I must add that if you search the scientific literature there is plenty of complete protein in plants. in case you were not aware.and there are many olympians on a plant based diet.
I was being assessed for ALS MND Motor Neuron Disease, I used mega dosing of B3 Niacin and B3 Nicotinamide to deal with my depression, my fatigue was off the charts with muscle wasting.. My depression was under control but at the same time I started taking ASEA Redox Signalling Molecules and after 2 weeks I stopped the mega dosing as my depression was lifted, my energy increased, running and power walking and am now working 6 days a fortnight, seeing muscle tone increased, my left hand still has spasticity but is increasing in strength and my right arm is improving also..
Praise God as I only started on the 7th August last month 2024 🙏 ..
I always believed that there is nothing impossible with God.
Such an answer to prayer, praying many more discover this supplement that will improve you life and health 🙏
🙏
❤
How much nmn do you take daily?
❤ so wonderful-thanks for sharing
Stansfield is a junior doctor who confuses clinical studies with personal effects and apparent personal animosity to Dr. Sinclair. I am 80 and have been taking NMN (~1gm) with TMG (2 gm) for 6 years. I walk 3-10 miles a day, and do some weight baring exercises. I have reduced carbohydrates and increased protein. I am convinced the NMN has been effective in supporting my activity. I still do very complex consulting in data analysis. I prefer to look out the window to see if it is raining than listen to a expert weatherperson! I agree with your approach and applaud your openness in discussing your experience.
Thank you. Really appreciate you sharing your experience too and glad to hear you're doing so well!
Could you please share the brand and sourcing for your MNM and TMG products please?
@@refuztosay9454 DoNotAge
You would be an interesting potential entrant into the Rejuvenation Olympics
Sinclair is synonym to fraud
I've been taking NMN for 6 months, starting at 250 gms then 500 gms. Added TMG about 2 months ago. I'm 70, still working 7 days a week, and still remember the early days of NMN where I'd have periods of buzzing round my shop feeling like I was in my 30s, though not with the same stamina. Now that's the new normal. When I took NMN at night I had a truly awful week of sleep because my brain just wouldn't switch off, so that was a negative proof if you like. Thanks for this honest review ~ I'll make my own experiment by splitting my dose into morning and afternoon - now I think about it, that seems an obvious thing to do ! I also eat in a 6 to 8 hour window each day, and started a carnivore diet more recently to fix some gut issues so it's hard now to isolate the benefits, but I do feel NMN has been a very positive influence.
Thank you for sharing this with us.
You have to take it in the morning, together with TMG.
@@Seeker_of_senseI take my nmn in my coffee, tmg before bed...any harm this way?
@@markmartin6436They work best when taken together (in the morning) to help keep homocysteine levels from rising.
@@markmartin6436 No, that should be okay. Dr. D. Sinclair takes 1 gram in the morning with joghurt. I take it with water. Sinclair said that natural NAD levels in your body underly a circadian rythmn and spike in the morning which is why he takes it in the morning. Taking it in the evening might make it harder to sleep.
Thanks I have tried NMN and I wasn’t sure if I felt a difference but listening to your podcast has helped. I’m 75 years old walk 2 to 3 miles every day and lift weights
5‘,5“ and weigh 120. Sometimes I’m embarrassed to tell people my age because they don’t believe me and that’s a good thing!
So glad you found it helpful
I have never heard of NMN until today. i have been looking for something to help damage cells in the prostrate, as I have BPH. Since you mentioned your father’s prostrate problem got better, i wonder if this would work for me. Loved all the information from this video. This could be a game changer for me. I am a male at 66 years old and looking out of the box.
@@rudylopez692Take a look at the sulforaphane studies on prostate cancer. You can incorporate this, along with INTRACELLULAR glutathione therapy. These protocols reverse prostate issues, and promote apoptosis even in cancer stemcells.
Same here but I am only... 74😂
Thank you for such a detailed account of both your experience and that of your parents. Glad you have seen such great results so far with our pure ingredients.
Dear Honest Channel, i have watched your first video also with Dr. Elena Seranova. Really in this video you look younger and more healthy. I think it works on you. I have started using NMN, TMG and Berberine also last month.
Thank you. It's such an interesting supplement and I'm sure there will be many more studies to come and more scientific debate but we all feel we've benefited from taking it.
I've been taking NMN, TMG and berberine for over 12 months now. My waist size has dropped from 28 inches to 27 inches and my body tone has definitely improved. However, I don't feel any different. I've always has no health issue. I'm now 45yo. I have recently started taking Creatine and Taurine, and have always taken Cod Liver Oil. I weight train only about 10 minutes, but on a daily basis. Also, I have started being able to lift heavier weights since starting on Creatine.
Good stuff! Consider adding intracellular glutathione therapy, and add an Activated B-complex to support methylation.
Thanks for keeping us updated on your family's experience w/ NMN. I stopped taking it about 6-8 weeks ago and feel less fit and energized. I am planning to bring it back into my supplement routine.
I remember you saying when I interviewed Dr Brad that you'd stopped taking it. Really interesting that you've had an energy dip as a result. I might switch to NR after I finish my current batch of NMN to see how I feel with that, but the weight loss and increased energy mean I'm unlikely to walk away completely!
You never mentioned the effects of berberine
@@thehonestchannelwas your weight loss as a result of having more energy to exercise?
Thank you to your parents for agreeing to be tested on. 🙂 Interesting subject.
Thanks for the personal trial with MNM! For NAD boosting, I've been taking liposomal NMN at 500mg/day along with 50mg niacinamide with 500 mg DMG for over a year. I also lift weights 4 times a week and do treadmill HiIt twice a week. I've always exercised, so I know it produces many benefits including NAD. But now, I weight train at the end of my fasting window in a fasted state... which is hard but makes me feel AMAZING! I also do intermittent fasting (17/7) and do 48 hour fasts every 10 weeks. So what does all this mean? Well at 67, I am still squatting 450 lbs and plan to set a world record by age 70 as the record is only 365lbs for this age and my 198 weight range. My theory is simple. Keep the body at a state that still is in the "REPRODUCTION CAPABLE" state. This extends quality of life. "DON'T LET THE OLD MAN IN!"😊
Wow amazing, do you have any other supplements to suggest in your protocol?
@geoffbendel9467 The body is a complex system and everybody is unique. So go to an integrative health professional and start with healthy oral hygiene. Consider Dr. Berg's protocol. .. Hydrogen peroxide mouth rinse. Next, work on healthy gut. Most people have LEAKY GUT
. due to all the pesticides. Consider Gut Restore by Ion and organic bone broth. I also take 5 grams glutamine with grass fed colostrum and kefir. Take this all together prior to breaking your fast before the first meal. Once your gut is healthy, you can start looking at other supplements. To boost glutathione, I take 1000 mg NAC and 5000 mg collagen (contains 4400 mg glycine)
Impressive. Did you notice an increase in lean muscle mass after starting the NMN? I have...
@geoffbendel9467 I've been doing Amino Acid therapy... taking 2 gm taurine, 2.8 gm beta alanine (different times) 3 gm HMB (post workout) and just added 2.8 gm creatine. However, I switched my NMN to NMNH... Doublewood brand due to the far greater NAD+ boosting for longer periods. I also am trying molecular Hydrogen by Dr Mercola. I feel 25 again!
@@Robbo_547 Started NMNH from Doublewood... AMAZING! Doing 60 lb dumbell curls l8ke they're 30s!
i have been taking NMN and also same about losing weight with minimal effort, also back to weight of my 20’s and i am 51. i stopped taking it for about a week and noticed it immediately. I only get exercise from yard work, and i have reduced the amount of carbs in my diet while boosting protein intake. i take a liposomal version of; MNM, Berberine, TMG and for me the liposomal version showed a much more noticeable positive difference everywhere except my wallet as it is a little more costly. I don’t regret the money i have invested in the last 4 months, in fact taking supplements my entire life, this has been the most effective investment i have made over the years.
Would you mind sharing which brands you like?
I'm also interested in your liposomal brand please.
@@scottbucc renue by science lipo nmn, the berberine code age, and apigenin code age. you have to take apigenin as is suppressed the cd38 protein that will consume any excess created nad from the nmn uptake. if you don’t take apigenin you will not see the benefits. my guess is the cd38 exist to consume any perceived “excess or extra energy that might be used by a cancer cell or zombie cells” So to prevent from feeding bad cells since i am 51, i did three months of liposomal fisetin benign a brand, 1200 mg for three days, every 28 days. basically mimicking a woman’s menstrual cycle to in an attempt purge the bad cells senescent or precancerous as i didn’t want to boost their nad levels. you will experience brains fog, at-least i did by day two of the fisetin uptake. but you only take it for three days then stop wait 28 days and start again. i also increased my uptake liposomal resveratrol during those three days, and liposomal curcumin code age. that was to encourage the zombie cells and precancerous cells into atophagy. i started to hit a plateau two weeks ago, so started full carnivore. i thought my energy levels couldn’t get better. Wow. a steak, 6 eggs and water, little butter and avocado oil one meal a day. i can’t believe the improvement. i also take NAC Glycine milkthistle 1000 mg each. i have a chest cold currently and worked 9 hours straight cleaning a rural lot, woke up this morning 6 hours of sleep feeling great.
@@MrRESolutions sorry for the late reply i am not so good at social media and checking replies etc. i hope the information i posted helps. i got my start reading dr laura kaufmann two books, the kaufmann protocol aging solutions, the kaufmann protocol why we age and how to stop it. i thank God everyday i saw an interview with her on modern lifespan channel. it has changed my life, inwas debilitated by gout in my hands knees feet now all gone after 3 months. i also read nathan s bryan phd, functional nitric oxide nutrition and take his N1O1 nitric oxide lozenges. i focus in less mouth breathing whenever i can. i take the seed synbiotic, after reading william davis md, book, super gut. i did take one bottle of restor flora pd about month two for 20 days. i stopped using fluoride products and switched to tooth paste that uses xylitol. it works my gums never bleed, almost no plaque build up and i had bad dental habits because i never liked the fluoride toothpaste. i quit using mouth wash that kills bacteria because it was killing the good bacteria in my mouth. i share this because i did all of these th8ngs at the same time, 90 days after starting i have seen a complete turn around, lost 30 lbs, never felt hungry, thanks to the liposomal berberine really killed my sugar cravings. allowed me to ween off that sugar addiction. now going full carnivore i have no hunger, i have an appetite same time each day before i eat my steak and eggs but no cravings for snacks which i cut out completely by month 2. i lost 4 inches in my waist and had to buy new shorts. and because i am older i take nattokinase by wright life. i no longer need the blood pressure meds i have been taking for 8 years.(losartan). libido is also like a 20 year old. it did cost money, but you can either pay the health stores now, the doctor twice as much later or the mortician. the books were important for me to understand why this concept of supplementation would work. i had to have the details, i am not as good at regurgitating them, but these doctors and people posting videos about increasing lifespan have completely changed my life for the better. Happy New Year btw. i hope you find what you are looking for on your health journey this 2024.
THANK YOU!!!! I greatly appreciate this perspective!
I do not. This so called " honest Chanel" should stop spreading lies about the NMN-HOAX.
As a 74 y.o. male with COPD I decided to try NAC + Glycine ( 1 Gram of each) around 5 months ago. Within 2 weeks of starting I found I had better oxygen levels which permitted faster walking and longer duration. As a byproduct to the improved oxygen circulation levels my cold feet are no longer cold, and my hair apprears to be getting darker. Tyhe only word of warning is to ensure you get good quality NAC from areputable company as there are many fakes around this unregulated industry. From Australia.
Thank you for sharing your experience ❣️ this was inspirational
Thanks so much for this - I was actually just reading about NAC. It looks really interesting.
Hi
Can you share the brand of NMN you use please
What a beautiful presentation so clear and honest. Personally, I take 500mg NMN, TMG, and resveratrol, sincerely I have never clearly understood the effects of these supplements, but I try to follow the results of research in this area, and I believe that we will evolve towards more conclusive results. I think research should focus more on why NAD levels decrease with age, rather than looking for strategies to increase them.
Being from Australia myself, what do you recommend for NAC brand? Ta
Hey Clare, another great video.
I totally agree with the need for more informative investigations into the use and beneficial claims made about MNM , NR and other precursor only supplements.
The discrepancies in your NAD+ blood test levels is no surprise.
Accurate and reliable at home consumer NAD testing is still a long way off. The reason being - the NAD coenzyme is extremely unstable and it degrades really quickly. The only way you can accurately measure NAD is through a process call mass-spectrometry and is used after any samples of blood are immediately placed on ice to prevent degradation.
I do agree precursor-only NAD boosters (like NMN and NR) do increase a person’s NAD levels but “lack of available precursor material” is not the reason for our declining levels of NAD
These pre-cursor only NAD boosters do not address the root cause of NAD decline as we get older.
There is also growing and concerning evidence over the use of NMN in isolation and the resulting short and long term impact of methyl donor depletion hence why one of the products you and your dad were using also needed TMG.
An effective and efficient NAD supplement needs to have a whole-systems approach that is backed by real clinical evidence in the form of human trials and addresses the root cause of NAD decline. These products do exist.
Keep up the awesome content.
Are you referring to Nushido supplements ?
Why not take NAD+ in the first place ?
Invaluable video that captures all angles.
So pleased you found it helpful - thank you.
I'm 66 and have been taking NMN for about 16 months now. I immediately felt results on day one. My energy levels increased, I no longer felt drowsy in the afternoon after lunch and I just felt better overall. I also lost 40 pounds over a five month period but I'm not sure how much of a role NMN played as I changed my diet as well. Before starting NMN I had decided to get in better shape also and started doing one thing I really love, day hikes. I live at 7000 feet in the Rocky Mountains and the hikes ranged from that altitude up to over 11,000 feet. At first I could only walk about three miles without feeling exhausted with minimal improvement until I started taking NMN. Almost immediately, my range improved to over four miles with another leap to over six without feeling beat. Now, I can do over twelve miles while reaching the high altitudes I mentioned earlier and, while tired, I'm not just totally worked. I also believe my pace is on par with what I could do in my thirties. NMN has had a significant effect on my life despite what Brad Stanfield says. I've come to the conclusion that he will take the opposite stance on just about anything that Dr. Sinclair and others do just to feed his own ego. I stopped following his TH-cam channel months ago.
If you feel results day one already then it is a placebo.. Because it can't work so fast..
I also take what Dr. Brad Stanfield says with a grain of salt. But it's good to have a devil's advocate in the longevity community. I like to consider the other side, too. That said, I'm also very grateful to NMN for boosting my own energy levels.
Your changes dont come from nmn but from your different lifestyle. Jesus open your eyes and save money
So true. Same with me. Brad gives appearance of a health hustler b
Dr. Stanfield takes an opposite stance and flip flops. This might
be to get more clicks on his channel. "Grain of salt" with this guy.
NMN and Homocysteine: NMN may theoretically increase homocysteine levels because it increases the consumption of S-Adenosylmethionine (SAMe), which is needed for homocysteine methylation. This could raise the risk of cardiovascular diseases. To counteract this, the intake of TMG (Trimethylglycine) is often recommended to balance homocysteine levels.
TMG and TMAO: However, TMG intake can increase the production of Trimethylamine-N-oxide (TMAO) in some individuals, which is also linked to an increased risk of cardiovascular diseases. These interactions between NMN, TMG, and TMAO are complex and require further research.
It's important to use supplements like NMN and TMG under expert supervision and after careful consideration of potential risks. Regular blood tests can help monitor for any adverse effects.
Would taking SAMe directly mitigate this instead of taking TMG?
Apparently that helps .
Does taking NAD supplements have the same effect on SAMe?
Thank you Claire 🌷 very clear and detailed review and super helpful like all of your reviews and recommendations 👌
Thank you so much ❤️
Amazing clarity. Tks
My husband and I have been taking NMN with TMG for over 2 years now and feel great with similar results to you. We are both in our early 70s and feel so fortunate to be able to take it.
Fantastic to hear this!
What is the link 4nmn..+ did u start low + increase.. good info here , tu
Do you take both together in the morning?
Thank you. This is the first video of yours I have watched and found it informative.
I do dowsing and muscle testing. The first few min of the video I was questioning the use of NMN for myself and others and kept getting a No. I thought that was odd. Then after you mentioned it was suggested to take NMN with TMG, I questioned again about taking NMN but with TMG for myself and others and then got a Yes. So I found that interesting.
I am taking many supplements and superfoods now however I will want to save this video and begin an NMN + TMG and possibly Berberine at some point when the budget allows.
NMN only is not good. But NMN taken together with TMG is good. Skeptical about Berberine, not for long term at least.
Loved this video- Consider me officially influenced to try the NMN and TMG supplements… fingers crossed that my results are as great as yours :)
I do hope you feel a benefit from using them. Let me know!
You're looking much leaner, better, and happier, Clare 👍
I think you're actually looking younger than at the beginning of the year!
Yes I agree. I haven't checked the channel for a year, and Clare looks much younger. Her skin is smooth and glowy, she also seems happy
Its filters
Is it filters? I think we should know because we use her as a barometer and piece of anecdotal evidence on how nmn might work for women our age. I would sincerely hope that she would say, 'thanks, may also be the filter I am using', otherwise it it very disingenuous.
Not heard of Botox ?
Appreciate your honest appraisal of this interesting supplement. I am definitey subscribing!
Hi Claire thanks for the update. I have been taking NR and TMG (250 mgr) for a year now and have experienced the same benefits as you describe . The difference being the much lower price tag. But then again you probably get your NMN for free.
That's really good to hear. I got the initial batch free but am buying my own now. I may well switch to NR for a while to see how I go. Did you experience the weightloss too?
@@thehonestchannel thankfully no weightloss as I’m superskinny as is.
Yep. NR is just as effective and a fraction of the cost of NMN 😃
Can I have the name of the company you use?
Really informative and honest thank you, and you've actually run your own trials, not just recycling others' viewpoints! I was talking to my brother (37) about NMN a few weeks ago and unbeknownst to me he'd been taking it for a while (500s) and does feel more alert from it. I'm 6 years older than my brother and about to place an order to try it myself. I'm hoping it will improve my sleep and boost my energy. Thanks for the great vid.
So glad you found this helpful! Hope the NMN works out well for you
so what's the result?
I am 76+ have been taking NMN for the same period of time as yourselves. I did not find an initial increase in energy as many in the U.S. reported. What I did find was that pains in my feet, particularly big toes, that had been there nearly 10 years and were affecting my ability to walk with no medical explantion, had dissapeared and after a month that the 'liver spots' on my hands were fading. Now though I do feel better, I stand more upright and I do not fall asleep all the time. I also take resveratrol and keep up my input of flavinoids though red/dark fruit and veg.
It took my almost a year to feel really good.
Same here, within weeks sore feet for a year disappeared
Since it's very expensive is it okay to take nmn 500 mg for a diebetic person 66 years old or should I have to take resveratrol as well
@@NliloLotha-c5i make sure it's actually real NMN. Buy from renue by science, DO NOT AGE or life extension.
great vid, i just started taking it, one week roughly, not much diference but, i do feel happier, and my skin does feel softer, havent lost any weight because i lost all that when i became a carnivour, and slightly more clear headed ... haven't grown any extra hair yet, but the new third arm is a bonus ;)
A few months ago, I start taking GlyNAC, NMN, and TMG. I only did NMN for a couple months and then swapped it out for Niacin because NMN was too expensive. I've been feeling the best I've felt in a while, and quickly somehow lost 15 pounds barely trying. I don't get tired half as easy when doing any kind of exercise anymore.
Just a word of warning to others, if you decide to use Niacin: in the large doses you need to take to affect NAD levels, it causes an intense flushing effect on your skin. It's really itchy, and your skin can feel really hot. It lasts 10-15 minutes, and it's not in any way dangerous, but the first time it can be a little scary if you're not expecting it. Some say that flushing effect also has a benefit to our skin by circulating blood through it.
Really interesting to hear your experience, thank you.
Interesting you commented on NAC cost when NMN is far more expensive.
You can purchase non flushing niacin.
@@jdxx59 If it's the slow release stuff you're talking about, you can get liver damage. I personally don't mind the flush. I feel like it's good for the skin.
Flushing niacin (nicotinic acid) lowers Triglycerides and increases good HDL
Thank you so much for useful info . I appreciate your contribution to society .
Wow this is so comprehensive! I’ve just had some more delivered from Youth and Earth. Now I’m wondering if it’s worth my money from here on in, having watched all this…. I can’t say I’ve noticed a marked improvement in either energy/sleep or pain reduction, but maybe if I STOP taking it I’ll take a dive. If this happens I’ll let you know, cos then we’ll know it was working! X
Let me know how you go with it. NR is a cheaper alternative so I may try that out for a few months.
Interesting and inspiring! Will ad this, a few days a week, to my supplement stack.
Hope you feel the benefit!
I love your vids; you bring a journalistic quality to the research of products, devices and practices. BTW: Anecdotal observation of course, but your skin and hair have improved greatly since your early vids. You are looking vibrant and beautiful. ❤
Thank you. I appreciate every word!
Thank for an excellent overview.
Ive been taking Vitamin B3 derivatives (NMN, NR) and now Liposomal NAD and B3 for 4 years. The energy and health benefits seem obvious to me. I can walk up to 8km per day and never feel tired. i sleep well and have lost 8kg since 2020. I first took it for recovery from Post viral fatigue (Covid) and it only took 2 weeks to take effect after being totally listless for 3 months prior. My latest regime is L-NAD (800mg) in the morning and B3 (500mg) at night, plus TMG (500mg) also in the morning. I am 58. I cannot recommend NAD boosting enough!
I've been taking liposomal NAD+ with trans Resveratrol 800 mg. I always know when something is beneficial when i stop taking it. It does help with my sleep, allergies, energy, and my skin looks much better😊 i will continue to take it.
Good to hear you’ve found a regimen that’s working for you. I agree, it’s often when you stop taking something that you realize it was actually making a positive difference.
If your Mother's B12 Injections were in the form of Methyl Cobalamin (likely)... that would significantly boost her system's Methylation efficiency. Low levels of AVAILABLE Methyl Groups is well known to limit lots of processes that require Methylation of precursor compounds...as is the case with NAD.
Thanks for flagging this.
Great to see superpowers coming together on one platform! Huat ah !!!!
Don't underestimate TMG - it is sold as helping with methylation, but it is also a good source of glycine and some people think that glycine supplementation can help you hit healthy glutathione and collagen levels. This is pure speculation, but I wonder if we need a good glycine + taurine to Methionine + BCAA ratio analogous to the Omega 3/Omega 6 ratio.
Interesting.
Hmmm. I have MTHFR so I can’t methylate. I wonder if this will help or hurt in my case.
That is a very informative video. Hopefully after one more year, please provide another update. I have subscribed.
Pleased to hear you found it helpful and thanks for the sub!
Thanks you Claire for this video. Using NMN as well for almost a year. Noticed the results very quickly in terms of the weight lifting at the gym and feel more energised (even though it didn’t solve some other challenges).
How about interviewing Marcel from the TH-cam channel The Pulse? He’s sharing his NMN journey for quite some time with amazing results (in combination with other supplements and exercising, mainly playing tennis. You will love his story.
Thumbs up and keep up the great work!
Hello Claire I feel the Berbrine is a key for the weight response
Hello! We stopped taking the berberine after a couple of months when we moved to the donotage powder and TMG capsules. Should have made that clearer. The weightloss became most obvious around 3 months in.
Great suggestion, thank you!
@@thehonestchannelI’m a new subscriber and really enjoyed your series on NMN. I’ve been sitting on the fence about NMN because of that controversial article on NR and its effect on cancerous tumors. I was happy to hear you and Dr. Elena addressed this issue!
Question: So when you switched to Do Not Age’s NMN powder, did you discontinue taking TMG & Berberine? I’ve taken Berberine before with no discernible difference.
@@helenareich9938 Great to have you as a subscriber! When I switched brands I stopped taking berberine but continued with TMG.
Dont know if NMN works, but you are amazing! You speak so well and are pleasant!
Thank you so much!
I can’t get my NMN anymore. Renue By sci nice stopped selling it. Where can I buy quality NMN?
Thank you. The discussion was appreciated and helpful. (a 77year old Australian). I haven't measured my quantities precisely relying on a combination of diet and an exercise regime and in general I feel very well. This has been over an 18 to 24month time period. As well my supplement' s being D3 , K2, C , D, B12, Zinc and Magnesium along with an occasional dose of Ivermectin.
Great to hear you're doing well and thank you for sharing your regimen.
Hi I’m in New Zealand how do you obtain and take ivermectin please? Or any videos you could link regarding it? I have rosacea and I believe ivermectin is effective against the demodex mite
Hi,also in Aussie,I like you take the same vitamins,however would like to know where you get the ivermectin from…I do have some some in a paste form but never taken it…🙏🌻
@dimcbride8969 hi, I had persistent rosacea. I was soon diagnosed with hashimoto's thyroiditis. Doctor prescribed levothyroxine and vitamin D. My rosacea has been gone completely for 4 years now.
I'm not saying that you will be the same. But maybe worth getting your thyroid and vitamin D levels checked. Best wishes
How solid is the evidence that raising blood NAD levels also raises cellular NAD levels?
No evidence
Thanks for your very informative Channel! I am 70 next month, have remained active in the gym for a good 25 years. I am at the same weight I was in high school. I do try to eat carbs only once a day if any at all. I typically fast 16-18 hours between my eating time. Until I feel I am beginning to fall apart I will stay with my usual routine. Thanks!
Sounds like you're doing great!
the fasting does nothing - since you are not a mouse..., it just preventys you from adding size.... so your weight is the same, but your muscle has been decreasing since you eat all your foods at once, an dthen stopping to eat....
Claire, you're looking younger and younger everytime I watch a new video of you. I believe you for sure
This happens. Someone having a super positive presence.
Very interesting video, thanks for bringing us your results. Being a bit of a geek, I did a very deep dive into NMN myself and this lead me to Dr Nicola Conlon's research on NMN and her company Nuchido. She's a British scientist who has created a next generation NMN supplement which is I believe one of the very few supplements to have undergone a rigorous double blind placebo clinical trial with published results. Her product aims to address the root causes of why our NAD levels decrease with age and I learnt a lot more about NAD from watching some of her presentations. I've been taking her companies supplement myself for 3 months now with very positive results so far, and in order to verify my subjective observations, I've also done a glycan age test prior to starting the supplement and will follow up with a repeat test in 6 months to see whether it has indeed lowered my biological age in any meaningful way. Anyway, I just wanted to bring this to your attention as I really think this will add a lot of clarity to the whole NMN debate.
Really interesting. Thanks for sharing this.
Definitely worth watching some of her presentations on NAD cellular biology on TH-cam. Also, in my research I found that researchers don't put much stock in the postal NAD blood testing kits as the active NAD degrades so quickly outside the body. That's why it's better to do a test like the Glycan age test and use this as a proxy rather than testing for NAD itself as this needs to be done in a laboratory. Although I stand to be corrected if I'm wrong as I'm not a scientist, just a guy doing some research online!
How do you get a Glycan Age Test please?
Please give an update? Its been more than 6 months
Hi, I just stumbled upon your channel because I just received my order of NMN 9000 Ultra from Allbe. I should've researched before ordering, but this resonated so much and I couldn't wait to start taking NMN. I'm approaching 40 yrs in a couple months and I have been combating RRMS for almost 13 years. And well it's never too early to give the body what it has very likely been missing for... most of its time on earth. I hope that I didn't do a bad thing by not first consulting my neurologist. In my defense tho the guy, without even stopping to consider, advised me to take the recent vakscene debacle.rotflmao. My discerning spirit would not allow me to comply. 🎉 I'll compare prices going forward after I finish my 3 bottle subscription. So in 6 months.
I’ve been taking NMN for six months, though it was hard to find and I had to have it shipped in from Canada. I started taking GlyNAC about four months ago, but it started causing diarrhea after about a month, so I have had to cut the dose in half, then half again! I started taking TMG two months ago, along with Creatine. So far the only positive effect has been that I have stopped losing muscle strength, and have been able to increase my weight workouts back up to five days per week (I had dropped down to three workouts per week, on my doctor’s advice). Other than that, I haven’t noticed any improvements in my appearance or health. I did start suffering from cold sweats at night beginning about one month into taking NMN. The only thing that has help my arthritis (both osteoarthritis and ankylosing spondylitis, which is in the rheumatoid spectrum) has been a large dose of MSM twice a day. I am no longer able to take the biologic drugs that had previously worked so well, due to the detrimental effects on my immune system.
Thanks for sharing this with us. It's good to hear that you're managing to work out five days a week again.
Take L-Citrulline for Nitric Oxide.
Could you share the brand name of NMN you had purchased from Canada? Tk you!
Brilliant video
Why don't you both try the B12 injection?
We didn't want to mess with our little trial but that's definitely something we'll look at now.
Hi Clare, thanks for sharing your NMN videos and results for you and your parents.
I'd be interested to learn how things have gone for you all whilst on NMN both for myself and my elderly Mother. Thanks🌈
I bought a five year supply of NMN before FDA banned it in U.S. It’s vacuum sealed with dryer packs kept in a deep freezer so it doesn’t deteriorate. I’m 65 and take it daily. NMN seems to help my general health.
Smart thinking!
Placebo. U waste a lot of money
It did officially get banned @raybod1775?
Your skin looks so amazing 😊
Thank you so much!
I have tried NMN and NR, I gave up both for just plain Nicotinamide. I take the plain Nicotinamide because the others are costly supplements which get broken down to plain Nicotinamide because of digestion. The digestion process breaks down the NMN and NR but this does not reduce their effectiveness as obviously they still do have an effect after your body reassembles them. The basis of my theory comes from research on skin cancer here in NSW Australia. .Oral Nicotinamide Prevents Common Skin Cancers so to me that means that the same mechanism that is aiding old people in maintaining higher NAD levels is the same whether you are taking plain Nicotinamide or NMN / NR. David Sinclair has admitted that plain nicotinamide is effective in raising NAD levels. I also eat a Vegan diet which has remarkably good effects on my health as well and David Sinclair has admitted he does too.
Thanks for sharing this Michael.
Interesting info.. thanks!
Šta je to obični nikotinamid?
vitamin B3@@nikolagolub9668
Great video. To hear it's actually working. Now I have to try it. Thank you
Thanks. There's definitely mixed reviews about NMN in the comments from other users. Hope you find a benefit if you decide to try it.
I love your attitude. Many would go the route of “ it’s doing so much good, I need more of that”, yours is completely different.
Thank you. I always feel that when we don't have a huge amount of evidence for so many of the emerging 'longevity supplements' and products we need to be cautious.
If you generate ATP, you will also generate free radicals and speed yp aging . You need SOD to put out the free radicals. Google Catherine Arnston.
Great video. Have you any information of taking NMN+resveratrol. Thanks
Niacin and niacinamide are well researched and good enough for me
do you take both? what dose of each?
Thank you for your update. If you're waiting for the US's FDA to approve anything they can't patient don't hold your breath.
Awesome report with clarity and genuine info❤ thank you
So glad you found it helpful!
Very good video🥰🇨🇦
Glad you found it helpful! ❤️
Thanks Clare, for this great follow-up to your NMN testing. It would be very interesting to see blood test results from an independent lab with no involvement from donotage, as a comparison.
The labs they use aren't owned by donotage so in that sense are independent, but it would definitely be interesting to do another test with an unrelated lab.
I am 70, frequent resistance training enthusiast as well as a hiker. I have two blocked arteries and CKD Stage 3A which has improved by eliminating fried foods and cordyceps. Started 300 mg NMN per day since June 24. Two observations: (1) improved strength training and recovery. ( increased libido. Other: Sleep has not improved. Sometimes I train too hard and need to nap right after workouts and protein supplementation.
I think you said you were also taking Berberine - surely this is more likely to be why you have lost weight as it works like metformin and helps with metabolism and insulin resistance. ??! Many people who take berberine lose some weight as it's a bit of an appetite suppressant ??!
I'm at the stage of being tired earlier than usual I have been taking NMN BUT I WAS TAKING ANTIDOTE SHILLIJIT LIONSMAINE AND SEAMOSS 3 IN 1 I HAVE NOW STOPPED THE ANTIDOTE SHILLIJIT AND NOW I FEEL AS IM NOT GETTING THE FULL EFFECT I HAVE LOST A BIT OF WEIGHT MORE ENERGY MY ADHD HAS GOT BETTER MY PTSD HAS GOT BETTER PRETTY EXCITED FOR THE FUTURE BECAUSE I AINT BEEN TAKING NMN FOR THAT LONG THANKS FOR YOUR CONTENT
Hi Claire, tryptophan can also increase NAD and is much cheaper. I've just started so I have not noticed any changes in energy but I take it before bed and I have noticed it helps me sleep. 🙂
I'd love to hear how you get on with it longer term.
Tryptophan reduces lifespan
I'll keep you posted!@@thehonestchannel
How so?@@pietercastelein2568
but tryptophan is inefficient, and any reasonable amount of it would be needed to increase NAD as high as NR
Thank You! Enjoyed your video. This is great information:)
Very well researched impressive video. I am curious regarding your weight loss. DId you only take berberine for one month or the entire time? Berberine is associated with weight loss so I am curious if you only stayed with theNMN or also took berberine...Thanks!
We only took berberine for the first six weeks or so until we ran out of capsules. I should have been clearer about that in the video. There was so much to pack in!
I take berberine daily and have for at least a year. I have gained post menopausal weight around my midsection since starting bioidentical hormones. The berberine isn't helping me in this area.
Great video, very nicely done.
Thank you!
I am 70 and have been taking 2 to 3 grams of NMN a day from DoNotAge for the past six months. My waist hasn't been so thin in nearly half a century. Am working out at the gym and stronger than ever before, jogging and milking cows on a kibbutz, very difficult work. My medical issues have nearly all disappeared. Through trial and error over decades I can definitely say that most of my results can be linked to NMN. Why don't they give at least a gram in human trials?
Thanks for sharing your experience. Pleased to hear you're doing so well.
I open with the fact that I’m a sucker for gimmicks, I wanted to say thank you for the video, your delivery feels far more balanced than some other channels. I’m 57 and physically train everyday, I wanted to boost energy so I watched Brad regards Taurine and took 900grammes of the bat (I know, I am an idiot) this had a adverse effect and caused an allergic reaction which resulted in breathing issues. It turns out that Taurine will affect allergic asthmatics, if you do a piece on Taurine would you stick a note into warn people of the potential dangers. I will research the NMN and test the theory. Really great delivery, Many Thanks, J
Thank you for this. I have taken note of that point about taurine and sorry to hear you were so negatively affected
I have to agree my own experience with NMN at age 66 is quite good. I have always been athletic cycling 8000 miles a year with 500,000' climbing but I was feeling more & more my age the last 3 years. Since taking NMN a gram a day for three months I am really happy with it & the results. As an aside I would like to say you yourself look very much better than your earlier video...Not that there was anything wrong with those videos which you showed clips of in this video but now in this video you clearly look healthier/younger more vibrant...It Shows! Thanks you for the video it was interesting & as I said echo's my own findings
Great to hear - and thank you for noticing my own positive changes!
I was recommended to take it for pcos. I’ve taken it on and off, but never committed. I may need to after watching this.
I use to take NR (for just over 1 year) and felt absolutely no different. I quit taking it and my pocketbook feels much better.
FYI there's a huge quality difference in brand and manufacturer. Tony Robbins talked about it; they bought several off the shelf and tested them. Some contained no active ingredient whatsoever! Assuming not every company was trying to scam, NMN degrades quite fast. It's not super shelf-stable (not sure about NR). But that could be what happened with the stuff you bought.
@@BrianThrivesI took the brand mentioned in this video, codeage liposomal, and Thorne. These are the brands I trust and in general considered to be top quality you can get. Zero difference. Nothing at all. I get a lot more change from a simple vitamin c shot. This did absolutely nothing for me. Regret spending a fortune on this scam.
@@xmyxymx
Perhaps you were already at an optimal level.
Very informative. Thank you.
Thanks for watching!
1:48 hahaha 😂 did you decorate a pile of books for Christmas?? I love it! I have shelves and shelves of books and piles here there and everywhere lol
Thanks for sharing your experience
Thanks for watching!
What is the best way to reduce crepey skin on the arms?
Resistance training has been shown to visibly improve skin quality so that would be a great place to start www.honest.scot/exercise/the-exercise-that-also-strengthens-your-skin/
One (or two ) avocados a day . This works within two weeks - proven
I am find similar benefits from MSM powder, increased energy, less stiffness, and better gut health. Cheaper too.
Thank you. Love your channel. You and your family are adorable.
Thank you so much!
Thank you - looking at purchasing but need to iron out the wrinkles in my understanding
Hope this video helped.
Couldn't the Berberine account for the weight loss you and yoyr dad have experienced?
We only took it for a couple of months. It’s a good point though!
Been on NMN for 2 years, felt the most benefits in the first few months, not so much afterwards but still taking it to be sure, yeah so maybe 3 month is all you need to reach optimal level.
I have recently started with intermittent fasting. I'm mostly following Mindy Pelz' IF advice. Still early stages with that so not much to report yet. (If IF gives you headaches then take a little salt with the water, is all I have so far). In general I think it's way too late to try and affect my life span. (I'm not sure I would want to anyway since I have very poor quality of life). But I take mineral and vitamin supplements, no tobacco/nicotine (ever) and very little alcohol, and I try to eat more veggies and fruit. I'm not particularly strict with my diet though, I eat sugar and less healthy foods sometimes.
I Just read your comment, it's sad you feel you don't have a great quality of life...
I think the best we can do for ourselves is try to live a better life rather than a longer life, as a result we may get a few extra years...
The reason I replies to your comment was to ask you if you heard of Red Light Therapy, if you're watching this kind of content on TH-cam then, i'm sure you have...
Personally I believe that along with a sensible and healthy lifestyle it's probable one of the best things you can do for your body along with practising yoga and everything else in moderacion...
It's very easy to get caught in the mindfield of suplements and
the trouble is, a lot of them do absolutely nothing other than make those manufacturers and suppliers rich... and in most cases you need to be taking something else to make something else work...
We are what we are, some people eat shite all their life, smoke a packets a Day and out live someone who had a healthier lifestyle, it is what it is...
If you haven't already then get yourself a Red light device, I believe it's a game changer...
If you need any help with that then let me know
Regards
Oh and IF, another game changer, definitely believe in the benefits of that...
Never is to late, just don't give you keep adding some supplements exercise
Thank you for your studies on mnm and nad. I am doing my best with what i have to work with...😮😊
You look amazing and younger than previous vids ❤ something is working
Thank you Anna!
I take NMN too, but I am going to switch to Rapamycin once we can easily get it. It has repeatedly been shown to reduce aging in humans, while NR and NMN have not.
That comes from Dr Attia, longevity expert
Thanks for flagging.
I still take NMN despite no one having been able to replicate good effects in humans. Rapamycin, creatine: those have a lot of evidence backing them from my reading of Attia and others.
Those placebo effects are remarkable
Yes, a lot of it is a płacibo effect but it does actually raise levels. It's not always a good thing. People abuse NMN and other NAD+ supplements because these companies sell it well. I've read so much research on NAD+ and although, it did have successful mice experiments, humans are not mice, but they also don't ever do their own research.
I, a retired physician, once got a patient from my older partner. He put her on about 10 meds, to which she unfavorably reacted. I took her off all meds and put her on 10 placebos. She did well. I checked on her after I left that practice. My former partner put her back on all 10 meds.
Interesting experience. Thanks for sharing. I've heard there are studies suggesting TMG potentially helps reduce white fat, increase brown fat, and may even maintain muscle mass while losing weight. Since you took both NMN and TMG together, I wonder if the TMG was more responsible for your body composition changes than the NMN. I'd be curious to see someone just try TMG and see what happens. There's a logical reason to take both together, but I wonder if it's obscuring which one is actually doing certain things.
Since NMN cannot legally be sold at the moment in the US, what do you recommend starting with if you live in the US? NR or Vitamin B3?
NR works great. Almost exactly the same as NMN
Hi, thank you so much for all the information, I would like to know what brand or where I could found a secure source of NMN. I went on amazon and I found lots of brands. Thanks for your time.
Thank you for a truly balanced video and your honest personal experience. I was going to work my way up to 1.5 g of NMN but I find my own sweet spot is 750 mg with the same amount of TMG, split over two or three daily sublingual doses. In my 50s. Energy levels are up. I feel less creaky. And my greys are going away. I use Renue by Science. I plan to increase thedose in my 60s or 70s or when my body hints at it. On the other hand, I may taper down in the future if I exercise more.
46 years old and 1.5g nmn for years now. No bad side effects. I sleep better than i used to. Still strong in gym and seem to heal faster from cuts etc. I have been blood tested for nad i am smack in the middle of optimal so i am sticking to 1.5g with an open mind to going to 2g later in life.....
Additionally, the researchers found that in mice, 4PY triggered inflammation in the blood vessels. This inflammation can lead to damage, including atherosclerosis, or the buildup of plaque in the artery walls. The study was published Feb. 19 in the journal Nature Medicine.
Lead researcher Stanley Hazen, M.D., says together the findings suggest that excess niacin is not just associated with an increased risk for heart disease but may also contribute to its development. The results could pave the way for treatments to reduce or prevent blood vessel inflammation, as well as diagnostic tools to help identify people who are getting too much niacin and may be at higher risk for a heart event, Hazen says
This is complete BS. Get prescribed Niacin FOR heart issues up until about 30ish years ago. Any “issue” with niacin is taking the niacin for present in NMN…which is the flush free version. The flush version is processed immediately. It is called nicotinic acid. The NMN niacin is Niacinamide or nicotinomide…these are NOT processed right away and get stored in the liver and can bullies up to toxic levels. Big pharma is engaged in a Full court press to discredit traditional niacin. If they wanted to prove it was not beneficial, they would run it 1:1 with statins and compare results. They have never done that, only paired with a statin versus just a statin. They concluded no benefit. Yet here we are, with heart disease as the number one killer in the US, even though we have these wonderful statins!
Follow the money. Eat right , exercise and Niacin. Supplements are just that. They supplement all of the aforementioned. We as consumers have bought into the idea of health in a bottle.
I do agree lifestyle should be the focus.