Mitochondria, Aging, and Health
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- เผยแพร่เมื่อ 4 มิ.ย. 2024
- Mitochondria are commonly referred to as the powerhouses of cells because they create the energy necessary for cell function; however, these organelles do much more than that within our bodies. At Targeting Metabesity 2020 (www.metabesity2020.com) this past October, an expert panel led by mitochondrial genetics pioneer Dr. Doug Wallace discussed the key role of mitochondria in aging and health. While other "hallmarks of aging," such as senescence and epigenetics, represent important targets for extending healthy longevity, mitochondrial dysregulation and sequelae, such as inflammaging, are at the heart of the complex of chronic diseases of aging called “metabesity.” Join our panel for an updated dive into one of the major drivers of aging and health.
About the Speakers:
Douglas Wallace, PhD, is a geneticist and evolutionary biologist at the Children's Hospital of Philadelphia in Pennsylvania, where he serves as Director of the Center for Mitochondrial and Epigenomic Medicine, and holds the Michael and Charles Barnett Endowed Chair in Pediatric Mitochondrial Medicine and Metabolic Diseases. More than 35 years ago, Dr. Wallace and his colleagues founded the field of human mitochondrial genetics, popularizing the concept of the ‘mitochondrial Eve’ from whom all humans alive today are descended. Wallace has a BS in Genetics and Developmental Biology from Cornell and a PhD in Microbiology and Human Genetics form Yale.
Francesca Fieni, PharmD, PhD, is the founder and CSO of Pano Therapeutics, a platform biotech company she spun out of UCSF focused on clinical development of drugs targeting mitochondrial ion channels to address complex diseases of aging and extend health span. Francesca earned a PharmD and a PhD in Neuroscience from the University of Modena and Reggio Emilia, Italy and subsequently pursued a postdoctoral fellowship at Massachusetts General Hospital, Harvard Medical School in Boston. She was an independent research associate/specialist at the University of California San Francisco before she turned entrepreneur.
Hazel Szeto, PhD, MD, is a research scientist, inventor, and entrepreneur in drug development. She received her MD and PhD in Pharmacology from Cornell and served on the faculty for 37 years. In 2016, Dr. Szeto left to direct research for Social Profit Network, a public charity supporting research to promote healthy aging and reduce age-associated disabilities. Dr. Szeto has developed the first class of compounds that selectively target mitochondria to enhance ATP production, repair mitochondria, regenerate tissues, and restore organ function. These compounds are now in clinical development sponsored by Stealth Biotherapeutics, a company founded by Dr. Szeto in 2006. Dr. Szeto’s research has resulted in over 200 peer-reviewed publications and more than 60 patents.
Michael Zemel, PhD, is founder and CSO of NuSirt Biopharma, where he leads research programs focused on energy-sensing and development of therapeutics for diseases of aging and over-nutrition. Previously, he was Professor of Nutrition and of Medicine at the University of Tennessee from 1990-2012, where his work focused on energy sensing, muscle-fat crosstalk, and regulation of adipocyte metabolism. Prior to the University of Tennessee, he served on the faculties of Endocrinology and of Nutrition at Wayne State University and as Research Endocrinologist at the VA Medical Center associated with Wayne State from 1980-1990, where his work focused on endocrine regulation of cell signaling and downstream effects on both blood pressure regulation and insulin sensitivity. Dr. Zemel received his PhD in Physiology and Nutrition at the University of Wisconsin-Madison. - วิทยาศาสตร์และเทคโนโลยี
Please put together a podcast with scientists addressing the Western Diet effect on killing mitachondria. Example, Corn Syrup injected in everything.
Yes second that. I take it you are familiar with the fructose work from Richard Johnson, Robert Lustig etc.?
very educational, keep on doing the good work.
Great work!
Great work guys. Very supricing about leucin
Dr.Douglas W fielding the question about Gilbert Ling was a special moment. around 1:18:00. Also 1:23:00 the question about EMF...wow.
Thank you for pointing out that moment, very much indeed.
It does seem about time now, that anyone who wishes to discuss metabolism, with any insight, were aware of these magical details ... from Ling, from Wiggins, from Pollack as well as from others. Exclusion zone / interfacial water's behaviour, and electromagnetic radiation, rotating ATP synthase ... what wonderful times.
?
@@marionharris5952 A lone question mark is hard to interpret. I will take it as an indication of curiosity. If you are interested in the real world mitochondrial function in the context of humans, Gerald Pollack gives a good introduction to water behaviour near interfaces (exclusion zone) - in a book '4th Phase of Water'. This zone is amplified by exposure to electromagnetic waves also known as light. Infrared light in particular penetrates deeply into the body, so can reach many cells and their mitochondria to effect their water structure in this respect.
Related, there is a growing body of evidence pointing to on site melatonin mitochondrial production during daylight from infrared-A. This is distinct from pineal synthesis at night, dependent on SCN signaling based on light input of ipRGCs. Many reasons to be outside as much as possible, exposed to sunlight ...
@Claude, are you sticking to a dose of 75g of glucose or do you consider bodymass (smurf vs giant) in the administration?
Love it 🔥
42:00 metformin
Does anyone know what "ATP turnover rate" (27:10) means?
Mean rate consumed changing into original form giving energy . This comment from my physiology learning in medical school before listening to lecture. I see comments before listening to any lecture. I might change my reply after listening. ATP is like money currency of energy.
From the lecture 65-200 kilograms of ATP produced every day .Amazing data we did not know studying in best medical school.
What ages/dies faster … mitochondria or other cells. ? Basically … what kills you … MC or non MC cells ?
Humans do have brown fat
Curious - can or will a body take an electron and use it? Like grounding... can your body use an electron from the ground for something like this or does it have to be generated this way and stolen
en.wikipedia.org/wiki/Photoelectric_effect
th-cam.com/video/NnRMRGsAHfA/w-d-xo.html
I believe externally donated. Ozone, steam depolarizing positively charged protons. After all most with inflammation can feel storms coming etc
Barometric pressure, plays a role in cell aggregation. As does radiation. donating electrons can be done externally to shift cellular status. Live blood cell analysis shows this in real time.
Disappointed the speaker prior to Francesca blamed metabolic syndrome on only high fat diets as that dogma does not comport with reputable science.
Except Dr. Wallace, the panelists look so unhealthy. How can unhealthy people have any clue as to what makes a human healthy?
Compare these people to Dr. Paul Mason, Dr. Brett Scher, Dave Feldman, Elliot Overton, etc.
Just as I wouldn't take financial advice from broke people, when it comes to health, I wouldn't put much weight on the opinion of unhealthy people.
High fat? High carbs!
Next slide ... yup.
😂Type 2 diabetes IS NOT CAUSED BY A HIGH FAT DIET but by a HIGH CARBOHYDRATE diet. Not sure why these “doctors” are so misinformed on “science”. 😮
You are clueless why we have mitochondria
Seriously!?? Does it get any more pale than this!??? The academia keeps marching backwards
Great , your all so smart . How about you tell us what we can and should do to enhance longevity, health , energy .... blah, blah , blah . Doesn't mean shit , if we cant implement positive change .
Exercise, Keto/carnivore diet, circadian rhythm and cold thermogenesis.
@@abzinokartelino5035 how's cold gonna help?
@@nootri brings respiratory proteins closer together, increases proton efficiency.
Agreed, they are anything but direct ... there are some clues here and there. If you caught the Gilbert Ling question, where Douglas replies referring to new water research (I mentioned Gerald Pollack in another comment, in his book Gerald does bring up Gilbert as well as Philippa Wiggins, along with discussions of his own research showing exclusion zone growing in exposure to light) ... a takeaway - live an outdoors life, optimise electromagnetic (quantum) yield in mitochondria.
@@abzinokartelino5035 You acquainted with Jack Kruse perchance?
Junk ... skip it . These filled are lost .
Junk seience... harmful.