A Mitochondrial Etiology of Common Complex Diseases
ฝัง
- เผยแพร่เมื่อ 22 พ.ค. 2017
- Douglas C. Wallace, Ph.D.
Director, Center for Mitochondrial and Epigenomic Medicine (CMEM)
Professor, Department of Pathology & Laboratory Medicine
The Children's Hospital of Philadelphia
He is our guru ( bioquantum hackers) too bad he has no time to go sub atomic. I have. Thanks to a career in solid state physics, semiconductors and biohackin’ and finally the disasterous health outcomes now over turned. Only if one gets very sick, will they become motivated to connect the dots of pharma history, funding of research, biology, quantum effects and etiology of mitochondrion dysfunction👏🏻
Had to speed it up 1.5x to get a decent pace. Just kidding, a fantastic jam packed mito talk.
Energy is life, then mitochondrias are life. Mitochondrias and the 2nd Law of Thermodynamics are the essence of everything.
Well, life is not just energy. If energy were life then nuclear reactors and the sun would be alive.
Could this be PQQ in interstellar space dust?
Having just watched another mitochondria talk (Chandel), it seems to me that autoimmune disease stems from lack of energy production in regulatory T cells. They showed that if you take out the mitochondria, the T cells survive and multiply just fine, but they stop taking any actions based on antigens, which resulted in autoimmunity for example.
Although they argue that it’s lack of h2o2 produced by the mitochondria which is a needed signaling function: maybe so, but that h2o2 can only be produced when energy production is ramped up in the mitochondria (from the calcium signal), so if mitochondrial atp production is lacking, it won’t get that h2o2 signal either.
And here’s the really interesting part. Excess iron in the mitochondria causes excess ROS via the Fenton reaction, producing super radical/hydroxyl OH from H2O2, which is very damaging. So it at the same time takes away the H2O2 signal needed by the treg to function. We shouldn’t throw all ROS in the same pot, these have opposite effects.
just take methylene blue..
pubmed.ncbi.nlm.nih.gov/32738205/
this paper touches on what you're thinking, it may be of interest to you
Whoa! I actually comprehended most of that 😅
Such a wonderful talk. Thank you for sharing.
What an enormously packed presentation! thanks for sharing this! Slowly we progress in knowledge but it just gets more and more complex as we continue to discover the actual workings of nature. How can it not be complex after a few billion years of evolution? We can't imagine how long that is so it is natural that we are surprised about the complexity.
Just so you know it is all G-d's natural workings and we are now only in year 5781 since creation. Keep in mind that at creation time all was already created, i.e a world all ready to go complete with one man and one woman! Only G-d could create such complexity.
@@tikipharm5957 don't fool yourself
When seen under a microscope, the array of things and it's general design and interconnected workings tends to make it evident of a creator behind it, it IS mind boggling...
Thank you for sharing this inspiring lecture! It's helpful to my own project. ❤
In fact, according to Wallace, it's the Mendelian theory of genetic traits being passed down that continues to be hammered into medical students at the standard medical schools. I'm not too sure standard Darwinism, let alone Endosymbiotic Theory is in the regular medical curriculum. Hopefully that will be changing.
Any and every change, must move away from the dismal results of our American Medical training. Nothing is getting better in any way. Just more convoluted business administration.
🎯 Key Takeaways for quick navigation:
00:50 *🧬 Common complex diseases like Alzheimer's, Parkinson's, diabetes, and obesity remain poorly understood despite vast research funding.*
02:41 *📚 Thomas Kuhn's idea of paradigms in science highlights the importance of initial conceptual frameworks in shaping scientific understanding.*
05:14 *⚡️ Energy, particularly mitochondrial function, plays a crucial role in health and disease beyond traditional anatomical perspectives.*
07:17 *🔬 Bioenergetic dysfunction is proposed as the root cause of common complex diseases, shifting focus from anatomy to energy metabolism.*
16:04 *💡 Mitochondrial DNA inheritance from maternal lineage ensures conservation of energy circuitry, vital for cellular function.*
21:20 *🧠 Different tissues have varying reliance on mitochondrial energy, leading to tissue-specific symptoms in mitochondrial dysfunction.*
22:30 *🔬 Mitochondrial bioenergetics play a crucial role in regulating energy, reactive oxygen species, and cellular function, affecting various aspects of health.*
23:13 *🧬 Inhibited mitochondrial function can lead to energy deficits, DNA replication errors, and age-related decline, potentially contributing to the onset and progression of common diseases.*
24:22 *⚕️ Certain mitochondrial mutations can result in diverse phenotypes, ranging from neurological symptoms to metabolic disorders, illustrating the complexity of mitochondrial genetics.*
26:38 *🧪 Transcriptomic analysis reveals distinct gene expression patterns in response to different levels of mitochondrial mutations, indicating a fine-tuned regulatory mechanism.*
27:18 *🔄 Nuclear-cytoplasmic interactions are essential for understanding mitochondrial pathology and disease manifestation.*
30:44 *🧠 Mitochondrial mutations can have varying effects on phenotype, influencing neurological disorders, diabetes, and cardiomyopathy, highlighting the importance of mitochondrial genetics in disease.*
35:19 *🌍 Geographic distribution of mitochondrial DNA variants suggests adaptation to environmental factors, such as altitude and climate, influencing disease susceptibility.*
39:35 *🔄 Mitochondrial mutations may exhibit context-dependent effects, with variants showing both beneficial and detrimental outcomes depending on genetic backgrounds and environmental factors.*
44:52 *🏃 Mutant mice with mitochondrial mutations exhibit collapse during exercise, indicating a progressive mitochondrial dysfunction.*
46:14 *🍔 Mutant mice with high mitochondrial levels resist high-fat diets and display insulin sensitivity, contrary to expectations.*
47:08 *🧠 Mice with mitochondrial mutations exhibit subtle behavioral changes, indicating potential links between energetics and personality traits.*
50:11 *⚡ Partial mitochondrial defects can affect long-range migration of neurons, potentially contributing to neurological disorders like schizophrenia or autism.*
53:07 *🔬 Research suggests mitochondrial bioenergetics could bridge Western and Eastern medical approaches, potentially impacting treatments like herbal medicine and acupuncture.*
57:19 *🧬 Mitochondria serve as environmental sensors, communicating with the nucleus to maintain homeostasis; dysfunction leads to bioenergetic decline, disease, and aging.*
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Fascinating talk. Please read Mae-Wan Ho who asserts that the body’s connective tissues and cells are attuned to each other in a quantum coherent field such that they form a liquid crystalline matrix which gives a rainbow effect under a polarising microscope. “The rainbow in the worm means that organisms are liquid crystalline and coherent to a high degree, even quantum coherent. This means that the entire organism is electrically polarized from head to tail, like a single uni-axial crystal. Not only are the macromolecules in all the tissues and cells perfectly aligned, but also the 80% by weight of water. Actually, it is the water that makes the entire organism liquid crystalline because this water is liquid crystalline, in the sense that the indi-vidual molecules are ordered and electrically aligned, much more so than in bulk water. Above all, in order to see the rainbow colors in the living organism, the liquid crystalline molecules not only have to be aligned, but also moving coherently, macromolecules and water molecules together. Because coherent molecular motions are much slower than vis-ible light vibrations, the ordered alignment of molecules will still be registered by the light passing through.” www.academia.edu/5706255/Superconducting_liquid_crystalline_meridians
ruthheasman ok . So. What's your take ? What should or can we do to live stronger , healthier and longer ?
@@dinomiles7999 Follow Ray Peat's suggestions by reading his written works at www.raypeat.com would be my best advice.
@@dinomiles7999 I have 10 years experience in improving mitochondrial oxygen utilisation. Oxidative therapies I'm prove oxygen utilisation by reducing NADH to NAD. Here is link to Dr Shallenberger's talk using Medical Ozone to fix almost all diseases th-cam.com/video/oHQBSnszTlA/w-d-xo.html
@@dinomiles7999 sunlight & supplement with D3/K2, magnesium, B50. Check your vit D levels. Follow Dr. Stasha Gominak’s youtube videos and her RightSleep program. Check zinc to copper levels and b12 too
Magnificent. Thank you.
Thank you!
21:10 Mito energy utilized by the brain is 20% :: 5% < loss mito energy could preferentially = headache
So helpful and enlightening!
Found this by reading a review from Jack Kruse on Dr. Goldner's amazon book. Funny how that works.
What does Jack Cruse say about Dr. Goldner? Is he sympathetic to green diet or mainly anti-food and more circadian light ?
🍻nuuuuu7y
Love it 🔥
marty laurence, i am 100% with you.
Interesting
I agree, Jack Kruse, that the Darwinian concept of evolution, particularly as conceived in the mainstream, the establishment, and the patriarchy, is characterized as a genetic arms race. This idea has won the day and has influenced (controlled) the direction of medical research, much to the detriment of human patients. It was about the magic bullet and the pot of gold at the end of the rainbow. This idea worked for infectious disease and the same approach has been used for metabolic disease (including cancer) with dismal results for patients and outstanding results for industry. Sequencing the human genome helped researchers, and the establishment, realize that genetics was not so significant and it is about epigenetics and the health of the microbiome.
There is a better concept of Darwinian evolution that remains suppressed from the mainstream: sybiogenesis or endosymbiosis. Bacteria, which dominate the planet have helped multicelled organisms along the way in a symbiotic relationship. Mitochondria were a bacteria that figured out how to process oxygen and formed a relationship with multicelled organisms. Without bacteria, there would be no, so called, macro evolution.
Then we get into the special requirements of particular species. It is the gut bacteria that allows a giraffe to eat acacia leaves exclusively, or a koala to eat eucalyptus leaves exclusively, or a panda to eat bamboo leaves exclusively. These animals, in the wild, eat only one thing and it is up to the microbiota to generate the essential nutrients the animal needs.
I won't get into the special requirements of the human species other than to say we do appear to have one, and it is unique to our species and determined by our evolutionary history and the origin of bipedal apes.
Martin Irving what is our food? Red meat?
Might be DHA for it’s vital role in the human brain. If the OP is into Jack Kruse, I know Jack is big on eating fish for the DHA.
Marrow no?
Invoking patriarchy in a negative sense generally suggests an individual to be some sort of communist.
"... Darwinian concept of evolution, particularly as conceived in the mainstream, the establishment, and the patriarchy,..." Spare us the pointless, hysterical, hyperbolic drama. The video is just another example of scientific understanding improving over time, in accordance with development of new methods and better ways of thinking about problems. But entrenched "establishment dogma" is not some nefarious conspiracy in which "they (whoever the hell "they" are) are trying to hide the truth," it's just the result of medical science being a human endeavor, subject to the same kinds of human weakness as any other human endeavor. New, valid paradigms may take a generation or more to become accepted, but as long as the mainstream of the discipline remains true to the dictum of scrupulously following the data to wherever they may lead, then the new ideas WILL become the basis for better standards of care. Now, calm down, not everything is a conspiracy.
Great lecture! Enjoyed the part on the differences between mendelian/anatomical diseases and mitochondrial/energy diseases!
Regarding the 8m mark, if 30% of the weight in humans is mitochondria (10^17 cells), that each have this electrical potential capacitor-like function.. any thoughts if exposure to external Light/PEMF can be beneficial/harmful? For example, isn't near infrared-light absorbed in the mitochondria by the Complex IV enzyme, leading to faster wound healing? What about magnet rings or magnetic mattress pads?
I get how a prolonged loss of Complex 1 function can gives rise to Parkinson's.. either through the decrease of ATP or the increase in metabolites (L-2GH, etc).. but why is it that a *minor* inhibition (Class A or Class B) of Complex I also appears to provide positive benefit?! For example, Metformin, a weak C1 inhibitor, seems to engage AMPK/autophagy, with signs of anti-aging, anti-diabetic, anti-cancer, and anti-inflammatory! Is it possible that the correlation between aging and the reduced mitrochondrial capacity (assuming the relationship is causal) is an adaptive response, not mal-adaptive, and attempts to increase output via intravenous NADH+ are not ideal? A better approach may be to slightly lower mitochondria output, such that it lowers the ROS (H202)/inflammation signaling and increases the 'low-resources' signaling? 57m
Regarding the 15m mark on why mitophagy and the 13 peptides used in C1-C4 are all encoded in the mitochondria (ex. PINK1 /PARKIN , Cytochrome C)... given nuclear dna has many more protective mechanisms (nucleosomal histone proteins, etc), coupled with the constantly replicating colony of bacteria/mitochondria within a cell, this seems more error-prone since any mitochondrial dysfunction to the mitophagy mechanism (caused by pollution, Rotenone pesticides, etc) would go unchecked and accumulate leading to aging/pathology, no?
Regarding the 35m mark, I've heard David Reich and Spencer Wells talk about work on mapping the human origin/migration/Phylogenetics.. did Wallace work with Reich/Wells?
I also recommend Doug's interview on the IHMC Stem Talk Podcast (14m, 47m, 58m. 1h23m)!
You have great insights on this topic. Your questions are well structured and are good grounds for further discussions, of which I would like to see (@UCLA CTSI). What is your profession, might I ask. I will follow your podcast recommendation and appreciate the timestamps. Regards.
Awesome presentation. The problem is... does fixing the mutation make the disease go away?
yes, practical application?
Hhmmmm
I used to concentrate at night and see these sparkling specks of light wiggling at me they would be red and blue for me and that would help me fall asleep as a kid. Now you mention it like that has me wondering a lot. Because 20 years later into my twenties I spotted those again in the preceding moments of a peyote trip. The specks turned into a spiraling ladder much like the so called DNA 🧬 and I feel I went down on it, or into it... Was pretty crazy from there on.
'might' be interacting. or indeed 'must' be unless they're magic and immune to the laws of electromagnetism?
Is there hope?!
Can anyone brilliant provide time stamps and summary .., I see this is more more true it’s about the energetics and I really think NAD creatine ubiquinol, magnesium and carnitine can be very helpful
2:24 paradigms
Genius! The question is what can we do to optimize our health??
Live in accordance with NATURE
Go listen to JACK KRUCE
@@freedomseekerz440 kruse
Reading Epi-paleo Rx: The Prescription for Disease Reversal and Optimal Health Paperback - March 20, 2013 by Dr. Jack Kruse and listening to Jack Krsue Podcasts and You Tube's would be helpful. Per Joe Cohen/ Jack Kruse You Tube interview
1. SUNLIGHT and LIGHT - Taken in the correct ways!
2. Circadian Rhythm
Light viewing behavior has the biggest influence on Circadian Rhythm.
We need to get bright light into the eyes first thing in the morning,
Sun and then full spectrum lighting.
It does two things it triggers healthy levels of cortisol which promotes wakefulness and the ability to focus throughout the day. It also sets a timer for the onset of Melatonin the sleep hormone to be produced later in the day. Melatonin is inhibited by light. So, by viewing morning light these two timers are set, the one, for wakefulness which begins at once and one, to produce sleepiness later after sunset.
Natural blue light early in the day is what you want 2 to 10 minute minimum
up to 2 hours maximum is optimal!
3. DHA
4. Limiting blue light
5. Water (spring water)
6. Sleep
7. Cold
8. Psychological Stress
9. Exercise
10. Diet
My personal # ONE thing for physical health is spiritual health ! -
None of us are getting out of this world alive. John 11:17-26
www.biblegateway.com/passage/?search=John+11%3A17-26&version=NASB
Sunlight.
Do mitochondria love chocolate?
I would think so. It must be all that PQQ in it.
👍🏿🙏🏿
Wish he would slow down
Jack Kruse brought me here.
CFS me is awfully painful
You might be able to appreciate ASEA
The chi part reminds me of the game Parasite Eve
Mitochondrial dysfunction leads to chronic kidney failure. Then mitochondrial reactivation should lead to reversal of chronic kidney failure.
I think I’ve watched this before. Don’t think I have different conclusions. The point seems to be that mitochondrial dna gets mutated hence lack of energy. Is there any evidence whatsoever other than case studies? Would seem to be as rare as any genetic diseases.
The idea is not well thought out. Since mtDNA inherits through the mother, any lineage with mitochondrial problems would never improve and quickly die out
EDIT: unless there was a selective advantage which there probably is. As is known, US population has lost about half a degree of body temperature since 1940 across all age groups. The lower energy production which this is a sign of would likely be responsible for pushing these mutations to the edge of resulting in symptomatic disease.
37:55 this is I’ll founded speculation. Northern ancestors don’t need less coupling to produce more heat. First of all you have brown fat cells that can already do that, you don’t take away energy from every cell in the body. Second, people have been wearing warm clothes.
I seriously don’t see what his point is. He goes on about breeding different mitochondrial mutations. If any of this was indicative of all the large increases in heart disease, cancer, diabetes etc then one could simply show that most patients share some of these causative mutations. Which clearly is not the case as all these diseases affect a similarly large population across geographies (eg in melting pots like the US), which mostly determines mtDNA
EDIT: He shows that for some of the known symptomatic mutations, there is increased risk of Autism given certain haplotypes. I don’t recall the details but it was only significant in a few haplotypes, and risk factor < 2 for a low risk just says this predisposes you more than other populations, but isn’t an explanation why the diseases are on the rise across populations, especially as there doesn’t seem to be a rise in occurrence of these mutations.
All I got from this is that the most common mutations are melas and lebers, which are rare, and have a very distinct symptomatic predisposition unlike what we see in he general population.
53:25 acupuncture works because it affects fascia which seems like a dynamic mold or mask around our body. Equating mitochondria with qi is a bit simplistic scientific, it’s pretty clear that most energy is produced in the mitochondria.
Regarding Dr Wallace’s talks on mtDNA mutation increased heteroplasmy effect on disease and a paper that doesn’t see any correlation of the degree of hetplas with symptoms, it’s probably different haplotypes that make it appear random, ie some are susceptible some are not (can’t find the paper).
He rarely mentions the fact that males are almost 10x more susceptible to develop symptoms, which renders his heteroplasmy graphs kind of useless for women.
Regarding keto diet for improving melas, as he says a colleague is claiming, I’m looking at the evidence. But it doesn’t make sense to me because the mitochondria doesn’t see a difference between ketones and glucose, both enter it as acetylcoa. So if he sees a difference it’s probably just the standard claim that ketones enter the cell more easily than glucose in diabetes, nothing to do with mtDNA.
For example, MCT transporters which move ketones into the cell, can be downregulated, just like the cell can become insulin resistant. Imo the cells are becoming energy resistant due to too much ROS, so it doesn’t matter if the energy arrives as glucose, fatty acid or ketones.
In Alzheimer, downregulation of MCT has been implicated:
Nitric oxide might be an inducing factor in cognitive impairment in Alzheimer's disease via downregulating the monocarboxylate transporter , 2019
“AMD3100 increases monocarboxylate transporters 1 (MCT1)”
Subcutaneous Administration of AMD3100 into Mice Models of Alzheimer’s Disease Ameliorated Cognitive Impairment, Reduced Neuroinflammation, and Improved Pathophysiological Markers, 2020
EDIT: I have to say I’m utterly perplexed. Keto, which is a baseless fad in general, may turn out to be uniquely beneficial for the melas mutation? I don’t quite understand the results. They create a high heteroplasmy melas cell that has respiration issues and turns to glycolysis, then ketones turn it back to normal, but only starting after 2 weeks?
Hard to speculate what’s going on. By replacing glucose for ketones, one thing that does change is the cell cannot use the energy from the initial glycolysis step, or even shift to glycolysis, to offload energy production. So maybe what happens is the forced usage of mitochondria over time shifts the heteroplasmy to a normal level, down from 90%, at which point it can produce more energy again.
Also they casually mention that the control cells also generated 50% more atp after 4 weeks on ketones, so it seems that pure ketones for these in vivo brain cells (which never happens in nature) increases energy whether melas or not, after 4 weeks, which is a long time not running on any glucose.
The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model, 2016
Many thanks.
The acupuncture hypothesis was just too much for me. If the 'treatment ' was scientifically credible, why continue repetitive clinical trials? Is greater than 3,000 trials not enough?
@@tfoxen7518 I don’t remember what he said about acupuncture, but I recall from some paper that acupuncture effectiveness may be more to do with stimulating the fascia layer under the skin.
7:22
Geesh talk about a lecture
57:25 cristæhyets
Your slides are terrible! They are unnecessarily detailed and interfere with comprehension, not enhancing it. You need to make the slides much more focused and simpler. The fewer the words and symbols and legends, the better. Your verbal delivery is pretty good but the slides destroy it.
I doubt he read your comment
The only two things I find missing in this lecture are one a creationist perspective and two the effects that the introduction of vaccines have had on this system. I realize this perspective is not popular but it is real. I appreciate the lecture and I believe there plenty of nuggets in here. The logic makes sense but if we only presume that evolution is fact we can become mislead. I believe that mutations have come from vaccines because many of these diseases we did not have prior to there introduction into the population along with EMFs and non native light.
❤️
The disease was the poison you ate . The headache was the inflammatory reaction. It makes sense for surgeons to specialize. But diagnostics is thinking big picture , theorizing, testing
The disease is the large amounts blue light your body took in and the amount of sunlight you didn't get.
@@binathere2574 well no . Poisoning the mitochondria with coal pollution. Don't get me wrong I'm under IR right now . But the body can tolerate non ionizing radiation much much much better then mercury lead uranium and magnetic nanoparticles. Sorry . You can damage a cell with non ionizing radiation for sure or magnets. But the #1 killer on earth is coal pollution
I thought you were funny a couple of times
This fella needs to do the "how to give a talk 101" course; he speaks far too quickly; it would seem he is showing off; he races through (at 16-17 mins) explaining mitochondrial genes; being in the nucleus; if everyone was able to keep up with the machine-gun pace of the talk; why bother to give the talk;
I do understand your concern...this is complex. This is not an 'entertaining' talk and I believe until we develop a vocabulary and a frame of reference we will not appreciate it. When I listen or study these deeper talks I use the settings and slow down the playback speed. Helps me.
Will hope Dr. Eric Berg covers this information in some of his next 4,000 You Tube talks.
Yes really. He is showing how fast he can talk.
Who is his audience? Maybe they don't need the 101 version. Maybe that's just you.
english is not my native. i can hear him well
Your "financial and political" distractions severely distract from your science and research, something you know little about (ref. Insurers, lawyers, Wall Street; form reflects function) Frankly your presentation has a huge dose of BS. Do better.
There are FIVE information codes in every cell, aside from blood cells. The five are the DNA code, the mtDNA code, the epigenome code, the 'sugar' code that lines the surface of every cell, and the lipid code making up cell membranes. All these had to work in unison. The makeup of these for life are mathematical impossibilities-by-chance. To say the ribosome sums up evolution is ludicrous. That is defined as a 10^50 or more. It's far too complex without outside intelligence to make it happen. On top of this, the Intelligent Designer is a master chemist with 65 different hormones in the human body. We are a creation.. Not an evolution.
Although this is great teaching, don't forget the much bigger picture. We were created by our creator. We did not evolve from monkeys. God is the one and only perfect creator and designer of us and our universe. Please read His love letter given to us, the Bible, cover to cover. Please learn about God's son, Jesus Christ, the only one who died for our sins. Our body is temporary. Our spirit will live forever. Don't sacrifice your soul just to prolong your temporary carcass.
i like my carcass
-Agreed Marshall Edwards. Mark 8:36...For what shall it profit a man, if he shall gain the whole world, and lose his own soul?
-There is no problem learning or understanding physical function for physical health...
but spiritual health has value for both now and eternity. I believe the healthiest lifestyle prioritizes spiritual health by faith alone in the Lord Jesus Christ alone, use of I John 1:9 and a daily deep dive into study and metabolizing the Bible which is the very Word of God and Mind of Christ. Matthew 4:4, Jeremiah 15:16.
@@cpg7804 So if you like it and want to preserve it, better ask Jesus to save you!
@@HCW2855HCW
save from what?
Oh shut up