You are quite literally the greatest educator that has ever graced the planet earth. You have a PhD+ level of understanding of every topic you cover, yet you know how to communicate it succinctly and simply. You were born to teach.
I agree he’s incredible - a genius for sure... not taking anything away - however, Jesus is the greatest teacher On earth ever in fact he is still teaching people worldwide how to live with purpose 🙏🏻
It was due to your teaching I passed my 1st Year MBBS with 75% and got 2nd Rank in my College. All set to ace 2nd Year with your lectures Dr. Zach. You deserve all the respect and love from all the students all over the world. A big THANK YOU to you!!!!!
You're literally teaching what's in my material (ppt), only thing you teach way better than my professor. Thank you so much for making this easy to understand.
what i love the most about your lectures that u explain physiology , pathology , and every single word u say and by that i gain so much knowledge not only about the main topic but a lot way more , no words could ever thank u enough , u r truly the absolute best in your field ❤
I already was passionate by phisiology and pharmacology - but u guys u made me head over heels about it. Congrats in everything you do. Helped me see things in such a easier way - even though really detailed
Great lecture overall, but one mistake at 9:48: the adrenal gland secretes epinephrine and norepinephrine at a 4:1 ratio. Thus, 80% of secretion is epinephrine and 20% secretion is from norepinephrine.
There is no words to say who u are how u are and what you are u r demigod u ur patience your hardwork and your teaching style words cannot describe how I felt like u know everything every topic we r blissed to have u tq so much 🙂👍🤗
u deserve all the best I hope this channel hits the 10 million subscribes , lots of effort and time spent while constructing it every time I meet my other medical student friends I tell them about this channel so I can help growing up this amazing work ,I hope I could help in more THANKS ALOT ❤❤❤
An interesting fact about beta blockers is that they can be used as a doping agent on healthy elite sportsmen. During training beta blockers maintain a reasonable cardiac output and muscle perfusion increasing performance as a conditioning agent. During training under normal conditions an increased cardiac output will increase blood pressure only to a threshold where the ventricles need enough time to fill their chambers with blood. If the heart rates increases beyond the threshold the ventricles will fail to pump the 125 ml per contraction. This will reduce tissue perfusion due to a lower mean BP. The beta blockers can keep the heart rate below the threshold effectively during training. This is why beta blockers are banned in competitive sports and considered a doping agent by the IOC.
Zach - when you are talking about Alpha1 antagonist drugs on the bladder with BPH (e.g. the -osins), don't you mean the indication is urinary RETENTION (2ndary to BPH) not incontenance? I though the idea was with BPH, we get relaxation by the A1 Antagonists, allowing relaxation at the prostate and internal sphincter, which allows for easier urination...
Bro said "had to take a lil break" = returns with different haircut. LOVE THE VIDS, all the way from SPAIN. I watch your vids at 2x to get a quick recap
Thank you so much Dr. Zach for your very informative videos,bcoz of your channel I passed the Veterinary Licensure Exam just now🥰u were such a great help to my basic understanding of physiology and pharmacology😊. I will surely share your channel with the future examinees of VLE.THANKS AGAIN AND GOD BLESS😇😇
He made an honest mistake, and you are right, it helps in urinary retention because it relaxes the internal urethral sphincter and thia causes urination
ur the best!!!!! med-1 student here:)) i literally skipped all my pharmacodynamics classes to follow along with you, and it was the best decision I ever made!
Thank you all as always for all of your great work and effort. I have a question, wouldn't alpha blockers be treating urinary retention/obstruction in case of BPH and not incontinence ?.
Hello and thank you for explaining everything so well. I was wondering how NE and E affects the receptors if they ever do overcome their natural affinity?
Thank you so much! Awesome explanation. Just an observation/question : Are alpha 1 blockers used for incontinence? Aren't they used for retention instead?
I discovered Zach's only weakness ( he spells the most famous Beta Blocker as Propanolol) ... he does not pronounce it as PropRAnolo) or even spell it. The imperfection that proves his legend.
Sir, you made a mistake at 9:41 when you tell that NE is the 80% released by Adrenal Medulla while it is the other way around. It is 80% EPINEPHRINE that is released by ADRENAL MEDULLA.
We dont prefer alpha 1 blockers forHTN bcz it decreases BP markedly on working at urinary bladder sphincter by micturition is it right concept so we should prescribe it when HTN+ BHP together
Sir is Harrison principal of internal medicine 19th edition is good for study medicine ? .... I mean I'm unable to buy 20th and 21st edition .... So is it okay to study from edition 19 ? ... Is there any major difference in these editions ?
hello professor! can you please explain the relation why erectile dysfunction will be an adverse effect of b-blockers? first aid stated it and im trying to find the correlation
Maybe from vasoconstriction of blood vessels by excess a1 stimulation and b2 blockage on vessels leading to less blood going to penis to cause erection. Maybe maybe.
i think you went for a haircut after beta 1 blockers lecture 😄, jokes apart you are Amazing teacher Zach, wish you all the best and please continue the great work. if you can do some videos on ortho, that would be a life saver for me.🙏
You are quite literally the greatest educator that has ever graced the planet earth. You have a PhD+ level of understanding of every topic you cover, yet you know how to communicate it succinctly and simply. You were born to teach.
I agree he’s incredible - a genius for sure... not taking anything away - however, Jesus is the greatest teacher On earth ever in fact he is still teaching people worldwide how to live with purpose 🙏🏻
@@desleykakoulidisgallaway3382 yeah, but Jesus didn't teach me anything about alpha-1 antagonists in the Bible
😊😊
It was due to your teaching I passed my 1st Year MBBS with 75% and got 2nd Rank in my College. All set to ace 2nd Year with your lectures Dr. Zach. You deserve all the respect and love from all the students all over the world. A big THANK YOU to you!!!!!
Why do lecturers complicate pharmacology so much tbh ,this is hands down the best explanation i've gotten. You are a gem Dr Zach .
Just a lil correction, the adrenal medulla produces or pumps out 80% epinephrine and 20% Norepinephrine (4:1 ratio)
Thank you for your beautiful work😍
at 29:13, shouldnt it be urine retention instead of urinary incontinence?
Yeah I also noticed it
I thought so too
You're literally teaching what's in my material (ppt), only thing you teach way better than my professor. Thank you so much for making this easy to understand.
I love how no matter what level of understanding you are at, you can always keep up with the video and clear your concepts. Thanks u Soo much!!!
what i love the most about your lectures that u explain physiology , pathology , and every single word u say and by that i gain so much knowledge not only about the main topic but a lot way more , no words could ever thank u enough , u r truly the absolute best in your field ❤
You'll be the reason why I'll pass my pharmacology subject. THANK YOU SO MUCH
Your videos are literally among the best in the medical field! You made pharma so much easier to understand!
you're my lifesaver. I could not get through my nursing career without you.
Thanks
Best pharmacology lectures on TH-cam
I already was passionate by phisiology and pharmacology - but u guys u made me head over heels about it. Congrats in everything you do. Helped me see things in such a easier way - even though really detailed
I am guilty in being addicted to ur lectures ，no words can describe how much I am grateful for ur hard work and fab lectures😘
Great lecture overall, but one mistake at 9:48: the adrenal gland secretes epinephrine and norepinephrine at a 4:1 ratio. Thus, 80% of secretion is epinephrine and 20% secretion is from norepinephrine.
I noticed this as well, 80% epi and 20% NE
ninja nerd, you're my goat
You are the savior of me and many students out there!
There is no words to say who u are how u are and what you are u r demigod u ur patience your hardwork and your teaching style words cannot describe how I felt like u know everything every topic we r blissed to have u tq so much 🙂👍🤗
u deserve all the best
I hope this channel hits the 10 million subscribes , lots of effort and time spent while constructing it
every time I meet my other medical student friends I tell them about this channel so I can help growing up this amazing work ,I hope I could help in more
THANKS ALOT ❤❤❤
Thanks!
Thank you so much without you I would fail every pharmacy exam I've ever had❤️❤️❤️😭😭😭
I have no words to express my gratitude to you! You are amazing!!!
I cannot express my gratitude and admiration, you are amazing!
This is such a great video, well explained, so beautiful drawings. Thank you so much
A "lil break"?! LOL You came back with a fresh cut and everything!! Love it !! Great Video!!
An interesting fact about beta blockers is that they can be used as a doping agent on healthy elite sportsmen. During training beta blockers maintain a reasonable cardiac output and muscle perfusion increasing performance as a conditioning agent. During training under normal conditions an increased cardiac output will increase blood pressure only to a threshold where the ventricles need enough time to fill their chambers with blood. If the heart rates increases beyond the threshold the ventricles will fail to pump the 125 ml per contraction. This will reduce tissue perfusion due to a lower mean BP.
The beta blockers can keep the heart rate below the threshold effectively during training.
This is why beta blockers are banned in competitive sports and considered a doping agent by the IOC.
you are the best at teaching this material. thank you
The bestest way of understanding. Sir please make videos on microbiology too
Thank you so much. I passed my exam today, depending on you. Thank you, professor
I thank you sir for your spectacular and remarkable lecture I must confess u are a legend
You made this course right when I took pharmacology. You are amazing my friend thank you
Zach - when you are talking about Alpha1 antagonist drugs on the bladder with BPH (e.g. the -osins), don't you mean the indication is urinary RETENTION (2ndary to BPH) not incontenance? I though the idea was with BPH, we get relaxation by the A1 Antagonists, allowing relaxation at the prostate and internal sphincter, which allows for easier urination...
you're right
Yeah exactly 💯
I was confused when I heard it 😊
Buh he's still the GOAT 🐐
I always find your videos interesting and I like how you describe things keep up the good work
Bro said "had to take a lil break" = returns with different haircut. LOVE THE VIDS, all the way from SPAIN. I watch your vids at 2x to get a quick recap
Thank you, sir, ❤❤❤ you are the best teacher❤❤❤
Sir, The Great Prof, Zach Murphy ❤
Thank you so much Dr. Zach for your very informative videos,bcoz of your channel I passed the Veterinary Licensure Exam just now🥰u were such a great help to my basic understanding of physiology and pharmacology😊. I will surely share your channel with the future examinees of VLE.THANKS AGAIN AND GOD BLESS😇😇
Still the BEST lecturer in TH-cam
🤩🤩🤩thank you so much , i love you Channel . Keep going . May God bless you and your team ❤️
Thanks ❤
Preparing for prometric exam and very very useful
Marvellous! Absolutely Marvellous!
UNBELIEVABLE HELPFUL!!!!! THANKS A LOT IS THE MINIMUM ...CONGRATS
respect on your name. thank you Zach!
Sir you are amazing. Can't thank you enough for your teaching. Inspiration!
@29.03 min you said urinary incontinence..it should be urinary retention due to bph?
He made an honest mistake, and you are right, it helps in urinary retention because it relaxes the internal urethral sphincter and thia causes urination
Really thank you!! You are the savior ,Sir 😊😊
awesome lecture, 28:21 our cute little sphincter muscle 😂
Was of great help. Thanks nerdy
ur the best!!!!! med-1 student here:)) i literally skipped all my pharmacodynamics classes to follow along with you, and it was the best decision I ever made!
You never Disappoint.. keep it up man ❤❤
My pharmacology exam is Thursday👀
Great work keep going 💙
Thank you all as always for all of your great work and effort. I have a question, wouldn't alpha blockers be treating urinary retention/obstruction in case of BPH and not incontinence ?.
Yes ..same doubt ,it should treat urine retention
But it will cause hypotension to pt , so use more selective a1 a,d blocker for only effect in bladder not bvs
huge airdrop in my medical base
May you be rewarded sir 👌🏾🔥
splendid we need more pharmacology
Thanks this helps tremendously
having the pathogenesis of pheochormocytoma in mind, why don't we use alpha-1 antagonists and but 1+2?
Bump, I also really want to know this
Thank you so much for this great explanation
love your content bro, you are a wonderful human being. thank you.
Hello and thank you for explaining everything so well. I was wondering how NE and E affects the receptors if they ever do overcome their natural affinity?
fantastic lesson
Thank you so much! Awesome explanation. Just an observation/question : Are alpha 1 blockers used for incontinence? Aren't they used for retention instead?
i think alpha 1 inducers retain the urine other hand alpha 1 blockers blocks or stops the activity to treat retention.
you're right
I discovered Zach's only weakness ( he spells the most famous Beta Blocker as Propanolol) ... he does not pronounce it as PropRAnolo) or even spell it. The imperfection that proves his legend.
Thank U Boss for Everything ❤❤❤
Amazing video! Extremely helpful
God bless you and gives you all you want , see you at 10 millions subs❤
ninja , you are the best . I wish I could be your direct student.
Love u 3000 ❤️
We are Ninja Nerds 🥷
Life saver fr, bless you man
Sir, you made a mistake at 9:41 when you tell that NE is the 80% released by Adrenal Medulla while it is the other way around. It is 80% EPINEPHRINE that is released by ADRENAL MEDULLA.
Where would you fit demetotomidine and clonidine?
You are intelligent. Thank you ❤
Would you hold an A1 blocker if the patient has BPH but is hypotensive?
good question
Give bethanecol (muscarinic agonist)
Nice one
Thank you, but u didn't cover the B2 blockers in this video. Are u going to prepare another video for this?
Best videos out there
Great video
well explained!🙏
You may be what gets me through school.
Thankyou Ninja Nerd
We dont prefer alpha 1 blockers forHTN bcz it decreases BP markedly on working at urinary bladder sphincter by micturition is it right concept so we should prescribe it when HTN+ BHP together
No words bro❤❤❤
can you teach us more about pathology
We love you
Keep it going❤
Muchas gracias por sus videos ❤
You are great ! 🤍👏🏻
You are a very good videographer.💯❤
Awesome!!
Thank you guys
YOU ARE THE BEST :)
Happy Teachers day 🎉🎉🎉🎉🎉🎂🎂🎈🎉🎉🎉🎂🎂🎉
You are fantastic
Thank you!
happy teachers man
Sir is Harrison principal of internal medicine 19th edition is good for study medicine ? .... I mean I'm unable to buy 20th and 21st edition .... So is it okay to study from edition 19 ? ... Is there any major difference in these editions ?
hello professor! can you please explain the relation why erectile dysfunction will be an adverse effect of b-blockers? first aid stated it and im trying to find the correlation
Maybe from vasoconstriction of blood vessels by excess a1 stimulation and b2 blockage on vessels leading to less blood going to penis to cause erection. Maybe maybe.
great sir
you are awesome 😎
i think you went for a haircut after beta 1 blockers lecture 😄, jokes apart you are Amazing teacher Zach, wish you all the best and please continue the great work. if you can do some videos on ortho, that would be a life saver for me.🙏
ZACHHHHHH THANK YOU SO MUCHH. ITY AINT ENOUGH HERE'S A NON EXISTENT OSCAR FROM ME TO YOU.