You are quite literally the greatest educator that has ever graced the planet earth. You have a PhD+ level of understanding of every topic you cover, yet you know how to communicate it succinctly and simply. You were born to teach.
I agree he’s incredible - a genius for sure... not taking anything away - however, Jesus is the greatest teacher On earth ever in fact he is still teaching people worldwide how to live with purpose 🙏🏻
It was due to your teaching I passed my 1st Year MBBS with 75% and got 2nd Rank in my College. All set to ace 2nd Year with your lectures Dr. Zach. You deserve all the respect and love from all the students all over the world. A big THANK YOU to you!!!!!
Great lecture overall, but one mistake at 9:48: the adrenal gland secretes epinephrine and norepinephrine at a 4:1 ratio. Thus, 80% of secretion is epinephrine and 20% secretion is from norepinephrine.
Zach - when you are talking about Alpha1 antagonist drugs on the bladder with BPH (e.g. the -osins), don't you mean the indication is urinary RETENTION (2ndary to BPH) not incontenance? I though the idea was with BPH, we get relaxation by the A1 Antagonists, allowing relaxation at the prostate and internal sphincter, which allows for easier urination...
An interesting fact about beta blockers is that they can be used as a doping agent on healthy elite sportsmen. During training beta blockers maintain a reasonable cardiac output and muscle perfusion increasing performance as a conditioning agent. During training under normal conditions an increased cardiac output will increase blood pressure only to a threshold where the ventricles need enough time to fill their chambers with blood. If the heart rates increases beyond the threshold the ventricles will fail to pump the 125 ml per contraction. This will reduce tissue perfusion due to a lower mean BP. The beta blockers can keep the heart rate below the threshold effectively during training. This is why beta blockers are banned in competitive sports and considered a doping agent by the IOC.
u deserve all the best I hope this channel hits the 10 million subscribes , lots of effort and time spent while constructing it every time I meet my other medical student friends I tell them about this channel so I can help growing up this amazing work ,I hope I could help in more THANKS ALOT ❤❤❤
There is no words to say who u are how u are and what you are u r demigod u ur patience your hardwork and your teaching style words cannot describe how I felt like u know everything every topic we r blissed to have u tq so much 🙂👍🤗
I already was passionate by phisiology and pharmacology - but u guys u made me head over heels about it. Congrats in everything you do. Helped me see things in such a easier way - even though really detailed
Thank you all as always for all of your great work and effort. I have a question, wouldn't alpha blockers be treating urinary retention/obstruction in case of BPH and not incontinence ?.
He made an honest mistake, and you are right, it helps in urinary retention because it relaxes the internal urethral sphincter and thia causes urination
Thank you so much Dr. Zach for your very informative videos,bcoz of your channel I passed the Veterinary Licensure Exam just now🥰u were such a great help to my basic understanding of physiology and pharmacology😊. I will surely share your channel with the future examinees of VLE.THANKS AGAIN AND GOD BLESS😇😇
I discovered Zach's only weakness ( he spells the most famous Beta Blocker as Propanolol) ... he does not pronounce it as PropRAnolo) or even spell it. The imperfection that proves his legend.
Thank you so much! Awesome explanation. Just an observation/question : Are alpha 1 blockers used for incontinence? Aren't they used for retention instead?
Bro said "had to take a lil break" = returns with different haircut. LOVE THE VIDS, all the way from SPAIN. I watch your vids at 2x to get a quick recap
ur the best!!!!! med-1 student here:)) i literally skipped all my pharmacodynamics classes to follow along with you, and it was the best decision I ever made!
Sir, you made a mistake at 9:41 when you tell that NE is the 80% released by Adrenal Medulla while it is the other way around. It is 80% EPINEPHRINE that is released by ADRENAL MEDULLA.
We dont prefer alpha 1 blockers forHTN bcz it decreases BP markedly on working at urinary bladder sphincter by micturition is it right concept so we should prescribe it when HTN+ BHP together
Hello and thank you for explaining everything so well. I was wondering how NE and E affects the receptors if they ever do overcome their natural affinity?
Im on Labetalol for hypertension as mine spikes above 180/120 regularly, currently on 9 tablets aday and have to take extra when I have a hypertensive crisis, I also have Intracranial hypertension and am on Topiramate. Still being investigated for causes Im only 32 though do have multiple endocrine problems, possible Pheochromocytoma or pituitary tumour.
Hello! Love your videos! I think the notes on the website and the written values on the video might include a typo. In lecture and web searching we are given EPI and (80%) produced and NE (20%) in a 4:1 ratio not flipped as shown in the video. Also the notes you give on the website also show NE being produced by the adrenal medulla twice. Not a huge deal but just wanted to give that feedback. There were some other things with other lectures I have noticed (minor details), and if there is a better way to inform about these please let me know!. Great Stuff all in all though!
GRT job man Something needs correction… @ 1:45… in side effects of beta blockers in hypoglycaemia….masking of sweating doesn’t happen, as sweat glands are supplied by muscarinic cholinergic receptors
I'm not even a med student but I love how you explain things 💝 Have you ever done a video on Biotinidase Deficiency or partial due to genetics or meds?
Sir is Harrison principal of internal medicine 19th edition is good for study medicine ? .... I mean I'm unable to buy 20th and 21st edition .... So is it okay to study from edition 19 ? ... Is there any major difference in these editions ?
hello professor! can you please explain the relation why erectile dysfunction will be an adverse effect of b-blockers? first aid stated it and im trying to find the correlation
Maybe from vasoconstriction of blood vessels by excess a1 stimulation and b2 blockage on vessels leading to less blood going to penis to cause erection. Maybe maybe.
![[UNCUT] The Loyal Pin ปิ่นภักดิ์ EP.4 (4/4)](http://i.ytimg.com/vi/d3l5rxl5CVo/mqdefault.jpg)
You are quite literally the greatest educator that has ever graced the planet earth. You have a PhD+ level of understanding of every topic you cover, yet you know how to communicate it succinctly and simply. You were born to teach.
I agree he’s incredible - a genius for sure... not taking anything away - however, Jesus is the greatest teacher On earth ever in fact he is still teaching people worldwide how to live with purpose 🙏🏻
@@desleykakoulidisgallaway3382 yeah, but Jesus didn't teach me anything about alpha-1 antagonists in the Bible
😊😊
It was due to your teaching I passed my 1st Year MBBS with 75% and got 2nd Rank in my College. All set to ace 2nd Year with your lectures Dr. Zach. You deserve all the respect and love from all the students all over the world. A big THANK YOU to you!!!!!
Just a lil correction, the adrenal medulla produces or pumps out 80% epinephrine and 20% Norepinephrine (4:1 ratio)
Thank you for your beautiful work😍
at 29:13, shouldnt it be urine retention instead of urinary incontinence?
I love how no matter what level of understanding you are at, you can always keep up with the video and clear your concepts. Thanks u Soo much!!!
Your videos are literally among the best in the medical field! You made pharma so much easier to understand!
you're my lifesaver. I could not get through my nursing career without you.
Great lecture overall, but one mistake at 9:48: the adrenal gland secretes epinephrine and norepinephrine at a 4:1 ratio. Thus, 80% of secretion is epinephrine and 20% secretion is from norepinephrine.
Zach - when you are talking about Alpha1 antagonist drugs on the bladder with BPH (e.g. the -osins), don't you mean the indication is urinary RETENTION (2ndary to BPH) not incontenance? I though the idea was with BPH, we get relaxation by the A1 Antagonists, allowing relaxation at the prostate and internal sphincter, which allows for easier urination...
you're right
An interesting fact about beta blockers is that they can be used as a doping agent on healthy elite sportsmen. During training beta blockers maintain a reasonable cardiac output and muscle perfusion increasing performance as a conditioning agent. During training under normal conditions an increased cardiac output will increase blood pressure only to a threshold where the ventricles need enough time to fill their chambers with blood. If the heart rates increases beyond the threshold the ventricles will fail to pump the 125 ml per contraction. This will reduce tissue perfusion due to a lower mean BP.
The beta blockers can keep the heart rate below the threshold effectively during training.
This is why beta blockers are banned in competitive sports and considered a doping agent by the IOC.
Best pharmacology lectures on TH-cam
I am guilty in being addicted to ur lectures ，no words can describe how much I am grateful for ur hard work and fab lectures😘
You are the savior of me and many students out there!
You'll be the reason why I'll pass my pharmacology subject. THANK YOU SO MUCH
u deserve all the best
I hope this channel hits the 10 million subscribes , lots of effort and time spent while constructing it
every time I meet my other medical student friends I tell them about this channel so I can help growing up this amazing work ,I hope I could help in more
THANKS ALOT ❤❤❤
There is no words to say who u are how u are and what you are u r demigod u ur patience your hardwork and your teaching style words cannot describe how I felt like u know everything every topic we r blissed to have u tq so much 🙂👍🤗
The bestest way of understanding. Sir please make videos on microbiology too
I already was passionate by phisiology and pharmacology - but u guys u made me head over heels about it. Congrats in everything you do. Helped me see things in such a easier way - even though really detailed
Thank you so much without you I would fail every pharmacy exam I've ever had❤️❤️❤️😭😭😭
My understanding level after watching your videos 📈
I thank you sir for your spectacular and remarkable lecture I must confess u are a legend
I have no words to express my gratitude to you! You are amazing!!!
I cannot express my gratitude and admiration, you are amazing!
I always find your videos interesting and I like how you describe things keep up the good work
Sir, The Great Prof, Zach Murphy ❤
Preparing for prometric exam and very very useful
You made this course right when I took pharmacology. You are amazing my friend thank you
Thank you all as always for all of your great work and effort. I have a question, wouldn't alpha blockers be treating urinary retention/obstruction in case of BPH and not incontinence ?.
Yes ..same doubt ,it should treat urine retention
Thank you so much. I passed my exam today, depending on you. Thank you, professor
A "lil break"?! LOL You came back with a fresh cut and everything!! Love it !! Great Video!!
Thank you, sir, ❤❤❤ you are the best teacher❤❤❤
Still the BEST lecturer in TH-cam
@29.03 min you said urinary incontinence..it should be urinary retention due to bph?
He made an honest mistake, and you are right, it helps in urinary retention because it relaxes the internal urethral sphincter and thia causes urination
Thank you so much Dr. Zach for your very informative videos,bcoz of your channel I passed the Veterinary Licensure Exam just now🥰u were such a great help to my basic understanding of physiology and pharmacology😊. I will surely share your channel with the future examinees of VLE.THANKS AGAIN AND GOD BLESS😇😇
I discovered Zach's only weakness ( he spells the most famous Beta Blocker as Propanolol) ... he does not pronounce it as PropRAnolo) or even spell it. The imperfection that proves his legend.
🤩🤩🤩thank you so much , i love you Channel . Keep going . May God bless you and your team ❤️
Thanks ❤
Thank you so much! Awesome explanation. Just an observation/question : Are alpha 1 blockers used for incontinence? Aren't they used for retention instead?
i think alpha 1 inducers retain the urine other hand alpha 1 blockers blocks or stops the activity to treat retention.
you're right
Sir you are amazing. Can't thank you enough for your teaching. Inspiration!
UNBELIEVABLE HELPFUL!!!!! THANKS A LOT IS THE MINIMUM ...CONGRATS
Bro said "had to take a lil break" = returns with different haircut. LOVE THE VIDS, all the way from SPAIN. I watch your vids at 2x to get a quick recap
huge airdrop in my medical base
May you be rewarded sir 👌🏾🔥
Marvellous! Absolutely Marvellous!
ur the best!!!!! med-1 student here:)) i literally skipped all my pharmacodynamics classes to follow along with you, and it was the best decision I ever made!
You never Disappoint.. keep it up man ❤❤
Nice one
Really thank you!! You are the savior ,Sir 😊😊
My pharmacology exam is Thursday👀
Great work keep going 💙
splendid we need more pharmacology
Sir, you made a mistake at 9:41 when you tell that NE is the 80% released by Adrenal Medulla while it is the other way around. It is 80% EPINEPHRINE that is released by ADRENAL MEDULLA.
love your content bro, you are a wonderful human being. thank you.
We dont prefer alpha 1 blockers forHTN bcz it decreases BP markedly on working at urinary bladder sphincter by micturition is it right concept so we should prescribe it when HTN+ BHP together
Hello and thank you for explaining everything so well. I was wondering how NE and E affects the receptors if they ever do overcome their natural affinity?
having the pathogenesis of pheochormocytoma in mind, why don't we use alpha-1 antagonists and but 1+2?
Where would you fit demetotomidine and clonidine?
awesome lecture, 28:21 our cute little sphincter muscle 😂
Amazing video! Extremely helpful
Was of great help. Thanks nerdy
Thank you so much for this great explanation
Thanks this helps tremendously
fantastic lesson
ninja , you are the best . I wish I could be your direct student.
Can you please 🥺 upload more lecture on pharmacology..
Would you hold an A1 blocker if the patient has BPH but is hypotensive?
good question
Give bethanecol (muscarinic agonist)
God bless you and gives you all you want , see you at 10 millions subs❤
Im on Labetalol for hypertension as mine spikes above 180/120 regularly, currently on 9 tablets aday and have to take extra when I have a hypertensive crisis, I also have Intracranial hypertension and am on Topiramate. Still being investigated for causes Im only 32 though do have multiple endocrine problems, possible Pheochromocytoma or pituitary tumour.
Getting me ready for CRNA school interviews over here
Thank U Boss for Everything ❤❤❤
Thankyou Ninja Nerd
Thank you, but u didn't cover the B2 blockers in this video. Are u going to prepare another video for this?
Hello! Love your videos! I think the notes on the website and the written values on the video might include a typo. In lecture and web searching we are given EPI and (80%) produced and NE (20%) in a 4:1 ratio not flipped as shown in the video. Also the notes you give on the website also show NE being produced by the adrenal medulla twice. Not a huge deal but just wanted to give that feedback. There were some other things with other lectures I have noticed (minor details), and if there is a better way to inform about these please let me know!. Great Stuff all in all though!
You may be what gets me through school.
Best videos out there
You are a very good videographer.💯❤
Love u 3000 ❤️
We are Ninja Nerds 🥷
You are intelligent. Thank you ❤
Life saver fr, bless you man
beautiful
well explained!🙏
Thanks
Awesome!!
Thanks!
Thank you guys
Muchas gracias por sus videos ❤
GRT job man
Something needs correction…
@ 1:45… in side effects of beta blockers in hypoglycaemia….masking of sweating doesn’t happen, as sweat glands are supplied by muscarinic cholinergic receptors
Thank you!
great sir
I'm not even a med student but I love how you explain things 💝 Have you ever done a video on Biotinidase Deficiency or partial due to genetics or meds?
You are fantastic
Hey Thanks dear!Please teach us Biostat also !
Sir is Harrison principal of internal medicine 19th edition is good for study medicine ? .... I mean I'm unable to buy 20th and 21st edition .... So is it okay to study from edition 19 ? ... Is there any major difference in these editions ?
Very good
thank you a lot
Please ninja , I want u to explain the CSF and BBB AND EDEMA 😔😔😔
hello professor! can you please explain the relation why erectile dysfunction will be an adverse effect of b-blockers? first aid stated it and im trying to find the correlation
Maybe from vasoconstriction of blood vessels by excess a1 stimulation and b2 blockage on vessels leading to less blood going to penis to cause erection. Maybe maybe.
You are great ! 🤍👏🏻
ZACHHHHHH THANK YOU SO MUCHH. ITY AINT ENOUGH HERE'S A NON EXISTENT OSCAR FROM ME TO YOU.
YOU ARE THE BEST :)
No words bro❤❤❤
We love you
Keep it going❤
God bless you for me