In my university, the lecturer explains all of this in a difficult way that only if you have studied everything you will know what he's talking about . Even though we study pharmacology for the first time this year . Nobody gets to the roots of subjects like you do . Thank you ❤️
Not only are you extremely effective at simplifying and making this content digestible, but you also share an incredible amount of enthusiasm when presenting your main points. I believe this is one of the reasons why people praise your work in every single video I watch. Thank you for that.
I am in currently in pharmacy school, not totally grasping the concept and this video helped me so much. I have followed you for years and you help me so much every time. Anytime I am minoring confused about a topic, I pray you have a video on it and you always do my friend. Keep up the amazing work
Thank you so much for all you explain. Many universities don’t have professors with the capacity to explain things the way you do, a way we all understand. drawing is the best source to remember things. Thank you thank you.
I saw those graphs about adrenergic agonists in first aid .. I couldn't understand anything from those pictures . .. after watching this lecture when I go back to first aid.. I wondered how easy was that.. this is his magic.. full of concepts..thank you
Thank you for this great lecture! I appreciate much your work. There is one little mistake at 12:00. The adrenal gland's average secretion is 80% epi and 20% NE
An alpha 2 agonist I’d also add that we use quite frequently in the ICU is dexmetetomidine. We run it as a drip for sedation. Works great for patients who we need sedated but still need a respiratory drive. Definitely see the effect on heart rate and blood pressure at times.
@@BarrelCollective It’s a direct alpha 2 agonist, which inhibits the release of catecholamines from neurons which leads to bradycardia/hypotension. Sometimes quite profound.
"Your videos are absolutely amazing! 🎉 The way you break down complex topics makes everything so easy to understand. Your teaching style is engaging, clear, and super helpful-exactly what I needed! Thanks to you, I feel more confident in my studies every day. Keep up the fantastic work, you're making a huge difference! 🙌📚"
I am actually blown away by your brain and how it can remember all of this info. I am watching your videos in hope they can teach me what my pharmacology lecturer cannot.....however its still way over my head. )-:
Honestly, I'm in a class that has NO lecture on pharmacology whatsoever. It's a "read the book and take the quizzes" kind of class. Thank you so much, I would send you my tuition money if I could.
Right on time! Im struggling on my uni with pharmacology cause lectures are bad and there is not enough study material. Thank you ninja nerd for teaching us everything
Thank you so much for this video! Helped me get through my Pharmacology exams! Would really appreciate another lecture with you about NSAIDS and DMARDS :>
I had a patient in the ICU who experienced intense reflex bradycardia from norepi! BP would increase significantly and then HR dropped into the 40's and occassionally patient would convert into a junctional rhythm! Very interesting to put two and two together!
This is very interesting to someone who has high blood pressure. I found out last year that drinking alcohol reduces my pressure significantly. Couldn't figure out why that is, but watching this video made me think it has something to do with the alpha 2 receptors. Is that right? Does whiskey act like Clonidine?
Alcohol is a ligand of GABA receptor (much stronger ligand than GABA itself) so it reduces the action potential of the cell, better said it calms you down. I guess the effect comes from that overall sedative effect it has on your CNS and all other subsystems being downregulated. That's my guess.
I have question! On the timeline the event that starts at 1:25:39: Systolic blood pressure going up it's for two effects: alpha-1 receptors on arteries and veins, alpha-1 receptors that are present on veins that's going to increase venous return, increase preload, INCREASE CARDIAC OUTPUT! The other thing is that there's beta-1 receptors and there is little bit of beta-1 receptor effect and you can increase contractility and INCREASE CARDIAC OUTPUT!! How the hack could be at 1:27:40 that CARDIAC OUTPUT HAPPENS TO BE NEUTRAL???? 1:27:56 now we have alpha-1 receptors ONLY on arteries (not on veins anymore?) that increases afterload and if we increase afterload, we DROP CARDIAC OUTPUT???? How could that be?
You're the best teacher I must admit, but at minute 11:53 I need a clarification on the percentages! Here is what I know, "In the adrenal medulla, this reaction goes still one step further to transform about 80 percent of the norepinephrine into epinephrine, as follows: 5. Norepinephrine Methylation → Epinephrine" (Guyton and Hall Textbook of Medical Physiology, 13th Ed. 2016). So I think Norepi is the one which at 20% while Epi is 80%
As your video lectures are very very informative Please make video lecture on Oncology topics like Breast Cancer colorectal Cancer Leukaemia lymphomas … highly requested
I wish you would’ve touched on dexmetotomidine while you were talking about Alpha 2 agonists. I think it’s sedative nature and adverse affects are confused in most people outside of those prescribing it
I have a condition which is called complex hereditary spastic paraplegia with cerebellar ataxia. The locus of the neurodegenerative disease is located on the axon Arg/Cys. I have always been treated with Xanax ( the classical treatment for Ataxia) while my dad takes Tizanidinewhich is an agonist of Alpha 2 Adrenergic agonist. Is norepinephrine realese due to some dysfunction in the Urea Cycle then ?
Take Guanfacine for Autonomic Dysfunction. Used to take Clonidine but was changed to avoid rebound hypertension. Autonomic Dysfunction due to removal of bilateral carotid body tumors and resultant vagus nerve damage.
Can the B3 agonits ,since they're located within the adipose tissues and helps breaing down triglycerides , be used to lose weight or to reduce fatts in our body ?
Perfect video, amazing breakdown of content. I love your videos. Keep it up please. Thank you for everything you and your team are doing to make our studying more amenable.
In my text book it is given that amphetamine increases the ne .and is used in adhd . But here professor said that clonidine used in adhd.but it decreases the NE
In my university, the lecturer explains all of this in a difficult way that only if you have studied everything you will know what he's talking about . Even though we study pharmacology for the first time this year . Nobody gets to the roots of subjects like you do . Thank you ❤️
Same here buddy 😂😂😂
@@moqaftaofficial5588 I guess they think they're lecturing post graduated students 😂
Maybe they lack deep level understanding and deliberately confuses you
It's same everywhere lol. It's actually with my N. Nerd
That’s because they just read slides and don’t really understand it themselves. Every university is this way
Why did i pay for expensive medschool lectures when this guy explains 100 times better!!
Because you don't become a doctor by watching youtube videos.
🎉
Not only are you extremely effective at simplifying and making this content digestible, but you also share an incredible amount of enthusiasm when presenting your main points. I believe this is one of the reasons why people praise your work in every single video I watch. Thank you for that.
I click on the " like button " even before watching because all of your videos are great!
I am in currently in pharmacy school, not totally grasping the concept and this video helped me so much. I have followed you for years and you help me so much every time. Anytime I am minoring confused about a topic, I pray you have a video on it and you always do my friend. Keep up the amazing work
Thank you so much for all you explain. Many universities don’t have professors with the capacity to explain things the way you do, a way we all understand. drawing is the best source to remember things. Thank you thank you.
I saw those graphs about adrenergic agonists in first aid .. I couldn't understand anything from those pictures . .. after watching this lecture when I go back to first aid.. I wondered how easy was that.. this is his magic.. full of concepts..thank you
Thank you for this great lecture! I appreciate much your work. There is one little mistake at 12:00. The adrenal gland's average secretion is 80% epi and 20% NE
Endocrinology | Adrenal Medulla | Catecholamines lecture at 8:24: 80% EPi and 20% NE
Thank you for uploading. I have exam in a month , thank you for saving my life.
The way you explain every detail of these topics helped me to clear my doubts & understand well, Thank you team Ninja Nerd.
An alpha 2 agonist I’d also add that we use quite frequently in the ICU is dexmetetomidine. We run it as a drip for sedation. Works great for patients who we need sedated but still need a respiratory drive. Definitely see the effect on heart rate and blood pressure at times.
It sedates via the locus cereleus on the spine but what’s its mechanism of action on bradycardia? Is it baroreceptor/vagus response?
@@BarrelCollective It’s a direct alpha 2 agonist, which inhibits the release of catecholamines from neurons which leads to bradycardia/hypotension. Sometimes quite profound.
This channel is a gift that keeps on giving, year after year!
12:40 yea basically norepinephrine means No-R-epinephrine which is the absence of R or Alkyl group in it. I read about this on reddit.
Wow!
"Your videos are absolutely amazing! 🎉 The way you break down complex topics makes everything so easy to understand. Your teaching style is engaging, clear, and super helpful-exactly what I needed! Thanks to you, I feel more confident in my studies every day. Keep up the fantastic work, you're making a huge difference! 🙌📚"
I am actually blown away by your brain and how it can remember all of this info. I am watching your videos in hope they can teach me what my pharmacology lecturer cannot.....however its still way over my head. )-:
I bought the member package because you deserve it. It’s been helpful as well to study the lectures you have
Thank you so much! You are making pharma so easy to understand and fun! Keep uploading sir
Honestly, I'm in a class that has NO lecture on pharmacology whatsoever. It's a "read the book and take the quizzes" kind of class. Thank you so much, I would send you my tuition money if I could.
thanks a lot for all the hard work that the ninja nerd team is providing ❤❤❤
Your love of biological sciences really shines through and reminds me of how much I love it too! Thanks for the excellent review.
Right on time! Im struggling on my uni with pharmacology cause lectures are bad and there is not enough study material. Thank you ninja nerd for teaching us everything
Thank God for sending Zackh Murphy into this world
Wish this was uploaded few months back...i had this in my previous sem but thank you sir 🙏
super simple explanation! great teacher! blessed are we to be able to hear you!
Thank you so much for this video! Helped me get through my Pharmacology exams! Would really appreciate another lecture with you about NSAIDS and DMARDS :>
Your videos are the best. Thank you!
I had a patient in the ICU who experienced intense reflex bradycardia from norepi! BP would increase significantly and then HR dropped into the 40's and occassionally patient would convert into a junctional rhythm! Very interesting to put two and two together!
Bro im convinced you guys are gonna single handedly get me through med school
Little bit correction- around 80% epinephrine secreted by chromoffin cells of adrenal medulla and around 20% norepinephrine by adrenal medulla.
Funny thing I just got prescribed guanfacine (a2 agonist) for ADHD. Explanation was superb
Damn the rationale is so good after all these years, these videos are still very useful thank you
Thanks man , please don’t stop and keep making great videos, appreciate it❤
This is very interesting to someone who has high blood pressure. I found out last year that drinking alcohol reduces my pressure significantly. Couldn't figure out why that is, but watching this video made me think it has something to do with the alpha 2 receptors. Is that right? Does whiskey act like Clonidine?
That's kinda tricky, there are many variables and unknowns
Alcohol is a ligand of GABA receptor (much stronger ligand than GABA itself) so it reduces the action potential of the cell, better said it calms you down. I guess the effect comes from that overall sedative effect it has on your CNS and all other subsystems being downregulated. That's my guess.
It does inhibit the sympathetic pathway that induces vasoconstruction by acting at the alcohol/barbituate binding site on the gaba br@@LukaTrenbolon
I have question! On the timeline the event that starts at 1:25:39: Systolic blood pressure going up it's for two effects: alpha-1 receptors on arteries and veins, alpha-1 receptors that are present on veins that's going to increase venous return, increase preload, INCREASE CARDIAC OUTPUT! The other thing is that there's beta-1 receptors and there is little bit of beta-1 receptor effect and you can increase contractility and INCREASE CARDIAC OUTPUT!! How the hack could be at 1:27:40 that CARDIAC OUTPUT HAPPENS TO BE NEUTRAL???? 1:27:56 now we have alpha-1 receptors ONLY on arteries (not on veins anymore?) that increases afterload and if we increase afterload, we DROP CARDIAC OUTPUT???? How could that be?
Thank you man, my wish is to this on my Language, this is amazing a wanna be Bosnian Ninja Nerd
Medicine can be pleasurable with your support
You ROCK sir!
Amazing lecture thankyou so much ❤❤
What would i do without these videos
God sent!!! Thank you so much ! ❤❤❤❤
God sent!!! Thank you so much ! ❤❤❤❤ Please make videos on Local Hormones
Thank you really explains everything, thank you for adding the quiz part at the end of the class, really helps with understanding the whole concept.
I don't know whether to thank you or cry...thank you
Thanks a lot for this video! Great explanation! Please continue making more videos on pharmacology.
Ninja is the best, Thanks
Thanks 👍💝
May Allah bless you.
Im in awe to have you.
You're the best teacher I must admit, but at minute 11:53 I need a clarification on the percentages!
Here is what I know, "In the adrenal medulla, this reaction goes still one step further to transform about 80 percent of the norepinephrine into epinephrine, as follows: 5. Norepinephrine Methylation → Epinephrine" (Guyton and Hall Textbook of Medical Physiology, 13th Ed. 2016). So I think Norepi is the one which at 20% while Epi is 80%
Thank you Chief ❤
At 33:20 you said that Blood pressure would increase and at 33:30 you said it is hypotension means lowering of blood pressure I didn't understand it?
Thank you so much!!! 💜💟🩷
you never miss 🙌🏾
Nerd at it again ☺️☺️
Love the videos, keep producing this incredible KNOWLEDGEABLE content! I'll be signing up with the ninjas to help support the channel!
افضل دكتور يشرح فارما
Extremely useful lecture bro❤❤❤
thank you very much you are amazing ❤❤
Alpha -2 agonist are indeed like symphato lytic reducing blood pressure like clonidine being used for hypertensive urgency
Thanks so much gor the video it has really helped me i couldn't understand in class
One of the best 🔝👌🏻
These videos helps a lot
🙏 I’m so grateful to meet you sir!!
Amazing class! Thank you so much!!!
Thunk u very much for making this easier 😊
As your video lectures are very very informative Please make video lecture on Oncology topics like Breast Cancer colorectal Cancer Leukaemia lymphomas … highly requested
great explanation!
Awesome content as always!
thank you so much ..,...PLEASE make video on CNS PHARMACOLGY sedatives, alcohol, AUTOCOIDS PHARMACOLOGY
this video is so good
Ninja nerd❤❤boomm
I mean, I'm learning so much thank you
So does that mean calcium channel blockers can affect the release of norepinephrine, via preventing or blocking the action of the vesicle?
goat of medicine nerdd
I wish you would’ve touched on dexmetotomidine while you were talking about Alpha 2 agonists. I think it’s sedative nature and adverse affects are confused in most people outside of those prescribing it
Thanks. You are awesome 😎
Love you ,you’re the best wallah
Love u 3000 ❤️
We are Ninja Nerds 🥷
Hi Zac, what book do you recommend me to use for this?
I love these lectures thank you
I have a condition which is called complex hereditary spastic paraplegia with cerebellar ataxia.
The locus of the neurodegenerative disease is located on the axon Arg/Cys.
I have always been treated with Xanax ( the classical treatment for Ataxia) while my dad takes Tizanidinewhich is an agonist of Alpha 2 Adrenergic agonist.
Is norepinephrine realese due to some dysfunction in the Urea Cycle then ?
Thank for explanation 👍🏻👍🏻
Take Guanfacine for Autonomic Dysfunction. Used to take Clonidine but was changed to avoid rebound hypertension. Autonomic Dysfunction due to removal of bilateral carotid body tumors and resultant vagus nerve damage.
Hi, I think the Adrenal Medulla, at rest, secretes about 80% of Epinephrine not Norepinephrine. Thanky for the good video though!
Please feed us more pharmacology lecture !
You are such an angel to me..
thank you as always!
thank you for these awesome videos!!!
Any videos on Chemo Induced N/V or the Chemo Trigger Zone specifically? ☺️
Excellent work, I'm in very impressed
Can the B3 agonits ,since they're located within the adipose tissues and helps breaing down triglycerides , be used to lose weight or to reduce fatts in our body ?
Perfect video, amazing breakdown of content. I love your videos. Keep it up please. Thank you for everything you and your team are doing to make our studying more amenable.
Good evening I hope you are doing well
Sorry for bothering I wanted to know how many lectures left in pharmacology,thank you for all your hard work
Amazing thank you
Thanks alot dr ninja i am from afghanistan me and my all friend watch your vedio
Don't forget us we are also your fans
Great description
Helpful! Thank you
Thank you so much for this video.
Thank thank thank you ❤❤❤❤❤❤❤❤❤
Herrlich und danke!
In my text book it is given that amphetamine increases the ne .and is used in adhd .
But here professor said that clonidine used in adhd.but it decreases the NE
amazing!!!! thanks