I have spent so much time trying to memorize pharmacology information and it was often useless because, I really couldn't recall the information later for functional application. Now, I know better, and just commit the time to watching these videos and develop an understanding first. Thank you so much.
I'm 18 and a second year medicine student having pharmacology as a main subject and this has been such an incredible lecture. Thank you so much for this. Lots of respect and gratitude for your hardwork.
currently studying for my pharmacology I exam and feeling like all my hard earned tuition money should be payed to you; thank you so so much for all the amazing lectures, I don't know what I would do without them
I truly enjoy the way you teach, I learn more from you than I have ever from any of my teachers, I am in nursing school and your videos are my first to go source for my learning. you rock. God Bless you!
I'm 4 years into my professional career and I'm still here looking for your lectures. Thank you very much for all the exams I overcome and the mistakes I avoid in my everyday work
You said "proximal convoluted tubule" so many times I may actually remember it 😆. Abbreviation resistance is rare from folks who know their stuff, shows education consciousness, nice work 👍
thanks for everything u are doing ，can't imagine passing any exam without your explanation，I really hope u were my professor at university❤️ most of my professors will just read the lecture (ppt) and give us extra assignments ..but u always care to explain the details in a simple interesting way ，thnx a million times🌹
You always help me in most of the subjects... you really know how to explain and make the information clear and easy. Other thing is that when I watch you I never feel bored..thanks alot and I really hope you all the best💖💖💖
-Attend classes -Take notes -Study for hours to undestand everything in depth -May pass exams or sit back and watch ninja nerd's videos to secure an A+
In the post op of liquoric fistulas, us ENTs give the patients acetazolamide to decrease the ICP as well, so the graft that closed the fistula will have less of a chance to move
answering why Thiazides cause vasodilation i found this. Vasodilatory effect: Thiazides also have a direct vasodilatory action, which contributes to their blood pressure-lowering effect. This is achieved through: Reduced intracellular sodium: Decreased sodium levels in vascular smooth muscle cells lead to reduced calcium influx via Na+/Ca2+ exchange, causing vasodilation. Increased potassium levels: Thiazides promote potassium loss in the urine, which can contribute to vasodilation by reducing calcium influx and promoting relaxation of vascular smooth muscle.
Last week I had a vented COPD patient in metabolic alkalosis and the critical care team wouldn't switch from furosemide to acetozolamide. I'm hoping your lecture helps me understand.
Yeah gotta be careful with that patient population they have a compensatory metabolic alkalosis 2/2 chronic respiratory acidosis makes it difficult to Wean off the ventilator
Hello an amazing teacher i have ever had I'm so much thankful to you for all videos I have one question how will potassium come out of the cell which don't have a potassium transporter for example in early distal convoluted tubule and proximal convoluted tubule? If you answer will be so much thankful to you ❤❤❤❤
Dude you look so happy in this video 😂 Anytime you laugh you really made me laugh too, that’s what happen when you do what you need to with love. Congrats, man, you’re doing a great work at renal physiology and it’s rly helping me
Great Lecture ! but isnt question 5`s answer supposed to be a thiazide diuretic as it decreases calcium levels in urine just like the patient requires ? 2:28:50
You say that loop diuretics inhibit the Na/Cl/K transporter, which causes less Na/Cl absorption and thus less water to be dragged and absorbed in the ascending limb of the loop of henle. But the ascending loop is impermeable to water and cannot absorb it. Did you make a mistake or did I misunderstand? Ps. Love your videos and really appreciate all the content!
To manage ascites, isn't it better to add up an ACEI or ARB to the regimn? That's true we've blocked aldosterone, but we still have AT-II which has similar effects to aldosterone.
Hey Ninja nerd. I have a doubt. In this video while explaining the Loop diuretics renal physio, you said Na, Cl, Mg, Ca are lost. But later on you said it is used in cases of Hyperkalemia to excrete excess Potassium. Can you please explain it. Thank you. Fan of your work
the reason for vasodilatation using thiazide diuretics is that these compounds are COX2 inductors in the vasal endothelium wich causes the release of prostaglandins
If we give potassium sparing diuretics, wouldn't that also decrease the proton loss, thereby causing metabolic acidosis? And if we were to continue the CA inhibitors, wouldn't they worsen the metabolic acidosis?
my brother in christ you're the only person that can get me EXCITED to watch a 2h30min class about diuretics
love this comment to pieces
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the best lecture on diuretics in the history of youtube, man you always surpass my expectations
No words to write. Such a phenomenal lecture.
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I have spent so much time trying to memorize pharmacology information and it was often useless because, I really couldn't recall the information later for functional application. Now, I know better, and just commit the time to watching these videos and develop an understanding first. Thank you so much.
Same 🥺🥺
I'm 18 and a second year medicine student having pharmacology as a main subject and this has been such an incredible lecture. Thank you so much for this.
Lots of respect and gratitude for your hardwork.
You are the reason I am passing medical school ❤
currently studying for my pharmacology I exam and feeling like all my hard earned tuition money should be payed to you; thank you so so much for all the amazing lectures, I don't know what I would do without them
Good luck on the exam! - TG
I'll have my pharmacology exam this next monday, this was such a welcome surprise!
I truly enjoy the way you teach, I learn more from you than I have ever from any of my teachers, I am in nursing school and your videos are my first to go source for my learning. you rock. God Bless you!
This channel deserves billions of likes
I'm 4 years into my professional career and I'm still here looking for your lectures. Thank you very much for all the exams I overcome and the mistakes I avoid in my everyday work
you are greater than a professor in our university who explained that for us in three hours and we couldn't understand
I pray to God that he gives me as much passion as you have . You inspire me a lot. Wonderfully taught.
The best pharmacology lecture i have ever watched in my entire life. thank you for this!!
Watched this video exactly 2 yrs later and I AM SO THANKFUL
The most detailed and understandable lectures on TH-cam
You said "proximal convoluted tubule" so many times I may actually remember it 😆. Abbreviation resistance is rare from folks who know their stuff, shows education consciousness, nice work 👍
He is great. It's very helpful when he repeats concepts and the names of drugs throughout the lecture.
I just found this channel now and it is literally the best channel I have watched
Best wishes
This man gave me a degree. Thank you!
thanks for everything u are doing ，can't imagine passing any exam without your explanation，I really hope u were my professor at university❤️ most of my professors will just read the lecture (ppt) and give us extra assignments ..but u always care to explain the details in a simple interesting way ，thnx a million times🌹
thank you so much. been coming to you for 4 yrs. i’m graduating from med school.
Thank you for making my studies so much easier! I wish they wouldve teach us like that
You really are a good explainer... You teach the way things are but in a simplified way. Thank you
In depth lectures need more like these
You always help me in most of the subjects... you really know how to explain and make the information clear and easy. Other thing is that when I watch you I never feel bored..thanks alot and I really hope you all the best💖💖💖
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Very open, clear and nuanced lecture, big thank you!
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When I chose to watch this video on Saturday evening instead of Harry Potter and didn’t regret!
Guys you’re the best! 2,5 hours in one take🔥
This is the best lecture of diuretics❤️❤️❤️ from Bangladesh
-Attend classes
-Take notes
-Study for hours to undestand everything in depth
-May pass exams
or sit back and watch ninja nerd's videos to secure an A+
I hit the like button before I even watch the lecture ❤ I appreciate you sir , thank you so much ❤ your lectures are helping a lot 🤩
You content is a gift from God!
You are a legend teacher. U deserve respect
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Thank you for all. You make pharmacology sensible ❤
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In the post op of liquoric fistulas, us ENTs give the patients acetazolamide to decrease the ICP as well, so the graft that closed the fistula will have less of a chance to move
answering why Thiazides cause vasodilation i found this. Vasodilatory effect: Thiazides also have a direct vasodilatory action, which contributes to their blood pressure-lowering effect. This is achieved through:
Reduced intracellular sodium: Decreased sodium levels in vascular smooth muscle cells lead to reduced calcium influx via Na+/Ca2+ exchange, causing vasodilation.
Increased potassium levels: Thiazides promote potassium loss in the urine, which can contribute to vasodilation by reducing calcium influx and promoting relaxation of vascular smooth muscle.
Your videos are helping me prepare for entrance exam,in India thanks a lot to the team
words can't explain how much you help us! thank you so much
I have finally caught that ninja who kicks data into my Brain🔥🔥
Last week I had a vented COPD patient in metabolic alkalosis and the critical care team wouldn't switch from furosemide to acetozolamide. I'm hoping your lecture helps me understand.
Yeah gotta be careful with that patient population they have a compensatory metabolic alkalosis 2/2 chronic respiratory acidosis makes it difficult to Wean off the ventilator
I SUPER LOVE THIS CHANNEL! PROVIDE SO MUCH LESSONS! :)
Helped me understand why my CHF meds are messing with my CKD. Wish you could work me up!!!❤😊
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Hello an amazing teacher i have ever had
I'm so much thankful to you for all videos
I have one question how will potassium come out of the cell which don't have a potassium transporter for example in early distal convoluted tubule and proximal convoluted tubule?
If you answer will be so much thankful to you ❤❤❤❤
Love from Bangladesh 💜 I go through ur video before studying my daily topics and it helps to a lot.
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I really learn, enjoy and mostly understand. Shoutout to u and happy belated birthday buddy
Dude you look so happy in this video 😂 Anytime you laugh you really made me laugh too, that’s what happen when you do what you need to with love. Congrats, man, you’re doing a great work at renal physiology and it’s rly helping me
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Great Lecture !
but isnt question 5`s answer supposed to be a thiazide diuretic as it decreases calcium levels in urine just like the patient requires ?
2:28:50
THANK YOU THANK YOU. YOUR VIDEOS ARE AMAZING AND SO HELPFUL. YOU ROCK!!!!
Yay🎉 I was looking for this then an hour later… got notification from our Ninja master ❤❤
You say that loop diuretics inhibit the Na/Cl/K transporter, which causes less Na/Cl absorption and thus less water to be dragged and absorbed in the ascending limb of the loop of henle. But the ascending loop is impermeable to water and cannot absorb it. Did you make a mistake or did I misunderstand?
Ps. Love your videos and really appreciate all the content!
To manage ascites, isn't it better to add up an ACEI or ARB to the regimn?
That's true we've blocked aldosterone, but we still have AT-II which has similar effects to aldosterone.
greatest channel ever
Awesome as always...could the thiazides effect on vasodilation be related to glomerulo-tubular feedback?
Unsure. My understanding is that thiazides can cause a relative hypovolemia which may activate the RAAS.
THANK U SO MUCHHHH I REALY NEEDED THIS VIDEO❤❤❤
Hey Ninja nerd. I have a doubt. In this video while explaining the Loop diuretics renal physio, you said Na, Cl, Mg, Ca are lost.
But later on you said it is used in cases of Hyperkalemia to excrete excess Potassium. Can you please explain it. Thank you. Fan of your work
Awesome...
I'm literally loving to learn from you...
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Thank you so much for doing such an excellent work for students.
You are the best teacher ❤❤
Amazing content! Thank you ever so much!
Thank you sir for uploading your notes 🎉
best lecture ever
the reason for vasodilatation using thiazide diuretics is that these compounds are COX2 inductors in the vasal endothelium wich causes the release of prostaglandins
Amazing lecture with g8 teaching skills 👏
great video but ascending limb of loh is impermeable to water right??
Great staff❤...worth it!
Amazing lecture.
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If we give potassium sparing diuretics, wouldn't that also decrease the proton loss, thereby causing metabolic acidosis? And if we were to continue the CA inhibitors, wouldn't they worsen the metabolic acidosis?
I am a very Big fan of your teaching
Thank U so much for your purely gifts to the world
So, is there a side effect of acidemia or respiratory compensatory mechanisms with carbonic anhydrase inhibitors?