Antiarrhythmic Drugs
ฝัง
- เผยแพร่เมื่อ 3 มิ.ย. 2024
- Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/ant...
@1:05:28 The alpha subunit Inhibits AC while the beta-gamma subunit activates potassium channels.
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Antiarrhythmic Drugs. We begin this lecture by reviewing Cardiac Physiology which will be essential in order to understand how these antiarrhythmics work. We will then go through the 5 types of Antiarrhythmic Drugs which include: Sodium Channel Blockers (Type I AAD), Beta Blockers (Type II AAD), Potassium Channel Blockers (Type III AAD), Calcium Channel Blockers (Type IV AAD), Adenosine + Digoxin (Type V AAD). After discussing these classes of drugs mechanism of action and indications, we will then transition into each of these types of drugs adverse reactions. We conclude this lecture by going over practice problems for Antiarrhythmic Drugs that we will be reviewing with you. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Antiarrhythmic Drugs (AAD) Introduction
1:35 Cardiac Physiology
49:37 Beta Blockers (Type II AAD)
57:05 Calcium Channel Blockers (Type IV AAD)
1:01:03 Adenosine + Digoxin (Type V AAD)
1:14:06 Sodium Channel Blockers (Type I AAD)
1:31:54 Potassium Channel Blockers (Type III AAD)
1:42:33 Indications for Antiarrhythmic Drugs
2:02:04 Adverse Drug Reactions: Beta Blockers (Type II AAD)
2:07:42 Adverse Drug Reactions: Calcium Channel Blockers (Type II AAD)
2:09:42 Adverse Drug Reactions: Adenosine (Type V AAD)
2:12:47 Adverse Drug Reactions: Digoxin (Type V AAD)
2:20:10 Adverse Drug Reactions: Sodium Channel Blockers (Type I AAD)
2:27:26 Adverse Drug Reactions: Potassium Channel Blockers (Type III AAD)
2:33:36 Antiarrhythmic Drugs Practice Problems
2:40:25 Comment, Like, SUBSCRIBE!
Pharmacology Source:
Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health. Kindle Edition.
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You made this 5 days to my Pharmacology exams. You're a G
Mine is tomorrow 😭😭
Almost 3 hours of a video= hard work= tremendously helpful and valuable information being given, thank you!
This is hands down the best pharmacology/physiology channel on TH-cam , thank you so much for making these Videos and keep them up!
I was literally just taught this topic this morning in my pharmacology class. Thank you for all you do, you guys have been a tremendous help in getting me this far in pharmacy school🙇🏾♀️🙇🏾♀️❤️
I taught this topic to my students this mrng,i learn more from ur explanation
I've never seen a better description on the pharmacodynamics of the drugs and ways to remember them; perfect video for cramming for a test lol
Your lectures help to clear the concepts about the particular subject.... our vision becomes crystal clear. No matter how many times I read antiarrhythmics, I used to get confused and frustrated. But hey, after watching this full video, I feel a lot confident about the topic now!! I really admire the efforts you guys put in to teach the subject. And I adore your capability to learn, understand and then teach any topic that you present. I am following you since a year now, and not a single lecture was there where I got bored or neglected the teacher 😉. You have the mesmerizing capacity to keep your audience glued to your lecture till the very end, and very few people in the world harbor this captivating ability... you stimulate me to study hard and harder. I can't thank you enough. Love you guys! Be blessed always. And keep teaching!!!
The excitement and enthusiasm to know this, rubs off!! Hats off to him🙌
literally the best teacher in the world.
Hands down the best channel to ace any concept regarding any physiological concept . Can't believe u taught Arrythmias so well that no teacher or any other video on TH-cam could have done
"Thanks for existing Zach "❤
Congrats on 2m!!🥳🎉 u guys more than deserve it! from the bottom of my heart, thank you Zach and team for everything that you do! idk how I would be getting through PA school without ur help! Ninja nerd for life:)
This video is exactly what I needed for pharmacology rn! Crazy how Ninja Nerd just knows.
this is actually fantastic. It is genuine practical explanation and relevance to clinicians. It isnt regurgitating a textbook and you've really thought about how to teach. great work
Can't thank you enough for these easy-to-follow lectures. So many future patients will benefit from this knowledge.
This is GOLD! Your enthusiasm is palpable! Thank you very much!
This is the best description and way of teaching Cardiac physiology and arrhythmias..... Thank you Doctor for Hard-work.
I seriously don't know what i would do without your classes.
As usual, you make a complex subject crystal clear! Sure your videos are longer than most, but it is so worth it!
This just cleared a lot of my confusion about anti-arrhythmic drugs. Definitely worth to watch! Thank you so much!
I appreciate your videos. I'm a firefighter/Medic and I watch your videos periodically as a refresher. Your take on physiology and the way you teach fits my learning style perfectly.
Im already finished with medschool but i still refresh with your videos.. amazing work thank you!!
No words can describe my appreciation to you and your team thank you so much your videos are life saving thank you for all your effort
Fantastic lecture! Thank you! I'm a pharmacist, and your lectures are my go-to for CPD
Honestly , one of his best lectures . Amazing
I can take only professor zach's classes continuously for hours, without losing focus for a min.... ✨✨✨...
You explain these topics so well! SO helpful
Great lecture; about to start ACP school and this helped a ton. Huge thank you; well worth the time!
Besttttt lecture on TH-cam i have watched alott of lectures but i didn't understand....it was sooo confusing topic but you made it look sooo simplee..... thank u zack❤
I love how you explean it with passion. Thanks man!
Hands down for this bewildering video. THANKS
Can't be blessed enough to be born in the era where we have You 🌠🧿. You are our true Ninja, who just support and help us achieve our goals that too with ease. People with ninja nerd family always ask for more n more blessings for you Mr. Zach and may God shower all the love, gratitude and success to you 🥰🙌🎊
And "as always until next time".💕
The best teacher with the best teaching method l have ever seen
This is one of the most life saving videos I've ever seen. I'm gona donate something beceause this is better than paid stuff and its free. This channels and all the team are the best!!! Really gratefull.
Thank you for this Masterful explanation! I have no words to say but Thank You
I don't take pharmacology but love listening to your voice before class, calms my anxiety 😅
You are great sir your lectures can make my concept really clear and i like the way that you teach to us
Best wishes to you ✌❤
Thank you Zach for your dedication and passion. I love details and you are a master in that! I always tell my class that if you want to get by learn the concepts, but if you want to make a difference or discover something learn the details. Hey I just discovered something - Double Quarter Pounder with Lecture and Fries Please. Mnemonic to remember the class I antiarrhythmic drugs. I love it!
Beautiful Explanation. Just Loved It❤️ You always make textbook reading very simple.
Amazing unique FANTASTIC VIDEO FOR ANTIARRITMYCS FOR MY STEP 1 thank you so much
You are the best!! Thank you for these high quality and incredibly engaging videos. Always makes my day :)
Good lecture Doc. I will say as someone who has taken both flecainide and currently propafenone this was very informative. HOWEVER, with propafenone it does have a minimum beta blockade effect as well. Grant it, it's not major but it's worth mentioning in full disclosure. I take propafenone for symptomatic pvcs, although now I am taking it post ablation,( which I had on March 17th this year while my heart recovers). Flecainide is a good drug, but it ran its course with me, (after 4yrs). I am 44yrs old. I thank GOD for my electrophysiologist who switched me from ditilazem to flecainide when he did. He is the same one who just did my cardiac ablation. NOTE: I had wpw, but that was ablated in 99 while I was a soldier at the young age of 20. Much of my pvcs came from that residual scar tissue from that first ablation. I hope and pray that I am done with ablations for the rest of my existence. GOD Bless.
GOD is always in firms!
Thank you so much for this! the questions at the end is really fun to answer after studying
this lecture was amazing thank you so much Zach!
Dude it's like you knew that I need this 😭😭😭😭😭
Thanks ❤️❤️
Great video with lots of information. Thank you!
Your help made me interested in medicine more than before
super helpful!! I was going to teach this topic. This is Exactly the video I was looking for ❤️
Protect this man at all costs!
Awesome lesson as always....thank you all
I am learning so much, thank you good Sir.
Your lectures are really informative Can you please make videos on pharmacology of other systems too? Thank you.
This is so helpful, thank you.
Wow I was thought this topic today in the afternoon in med school, I'm preparing to write pharmacology test by end of this month. I pray I pass coz there are lots of things to know like drugs and mechanism
U are a great person, great teacher with so much positivity. U are amazing. may Allah Almighty gives u more strength, power and fulfill all of your wishes . Great respect and love ❤
Thank you for your lectures. We would like to see and hear clearer the names of drugs you are taking about. Best wishes from patients. 💐
all this useful knowledge for free, thank u so much
Ninja nerds videos are the only videos that I like before I even watch the video
Thank you very much for all the help. ❤
I came here because I'm talking carvedilol and somehow it changed my heart rhythm even though the cardiologist says it didn't Now he sent me to the rhythm specialist to get an ablation... Anyway I came to educate myself... You're the best Ninja nerd 🤓
1:47:45 The " proarrhythmic effect " of class 1C antiarrhythmic drugs is likely related to their effect of decreasing myocardial conduction velocity , which predisposes to myocardial reentry around and through regions of infarcted myocardium .
Love from 🇮🇶
Thanks for all your hardwork 💯
I was waiting for this video, nothing to say but, you're the best.
Can you kindly discuss the Anti-cancer Drugs? Btw I have my Biochemistry VIVA next week. All your Physiology videos helped me a lot. Thanks.😊
Your videos are very helpful thank you soooo much please continue presenting helpful videos 😊
thank you so much Zach I was waiting for this video
Great video great explanation thank you for your effort 👍
Outstanding work! Thank you!
Thanks for the explanation god sent
thank you for the lesson, sir! I hope there are more video of cardiology
Thank you 🤗 appreciated
Tomorrow that's our topic
love your devotion
May God continue to bless you....🙏 Thank you very much😊
Is it the gi betagamma subunit that activates the voltage gated k channel?
Thank you Zach you are the best ❤
Thank you ninja you're a blessing.
Thank you sir
Very informative and helpful lecture ❤
THANK YOU SOOOO MUCH ZACH!!! YOU'RE THE BESTTT
EXCELLENT, EXCELLENT - THANKN YOU! I just became a member to download all the goods!
thank you perfect video ! can someone answer this :
slowing down the influx of sodium ions into cardiac muscle cells causing a decrease in the excitability of the cells it has a beta adrenergic blocker which can cause bradycardia and bronchospasm :
sotalol
propafenone
verapamil
mexitilene
GOD BLESS YOU ! you're the best! thanks a lot!
Hey Could anyone explain How can B-Blocker helping in this situation? Would'nt the Voltage Gated L-Type Calcium Channel open without the fact whether it is Phosphorylated or Not? (Given Sufficient Potential is Present) or Does it need to be Phosphorylated AND Sufficient potential should be present for it to open?
Micturition reflex. Do not forget the muscarinic cholinergic effect on m2 receptors of internal urethral sphincter to relax it from S2S3S4 intermediate zone lamina 7 thru pelvic plexus to urinate. Thank you very much
2:19
So helpful, thank you so much
Thank you dear!Nice explantion!
Thank you for this great illustration.
I’ve got a question ..
Early in the lecture it was demonstrated that L-type Ca+ channels are responsible for phase 0.
Later when you explained MOA of B-blockers ( that they block L-type Ca+ channels) , but the effect is manly on phase 4 of action potential not zero .!
I wonder why is that the case ?
I would be glad if you can explain it .
Thanks again for your amazing lectures ❤
My god this is so well thought well done sir
Thanks Ninja Nerd :)
I have a question for you or anyone...
I have read various things in textbooks reagrding the the downstrem effects activation of b1 receptrs and cant get my head around it.
In some texts they mention that the mechanism for increasing heart rate with B1 agonism is increased Na influx through the funny current, therefore increasing membrane potential and the slope of phase 0 leading to increased conduction and HR. So therefore b-blockers would block this and cause a reduced slope of phase 4.
I guess im confused as to why the slope of phase 4 (and not more so phase 0) would be prolonged when blocking the L type Ca channels if the Ca channel involved in phase 4 is T type, along with the funny current.
i heckin' love prof. zach
Thank you very much Ninja Nerd
I was diagnosed with wolf parkinson's white syndrome and had a cardiac oblation what are your thoughts on that
I relly like the way you explain it, keep it up bro
Different methods of learning. Am made to learn this way.
Just love your work man
i freaking love this man
Thanks for the content!
Brilliant dear Zach
Congrats on 2M I wish I could donate you but I will surely in future 👏👍🏻
Life saving lecture
amazing lectures
thanks for all you do.
Outstanding ❤
Zach, in an earlier video you note that Mag given to severe asthma patients causes relaxation by its action on calcium channels. But here, when discussing TdP, you note that the mechanism by which mag works it’s unknown. It sit possible that they work by the same mechanism-namely, it’s effects on calcium channels?