Generation and action of siRNAs and miRNAs

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  • เผยแพร่เมื่อ 11 ส.ค. 2014
  • In this animation, we discuss how siRNAs and miRNAs are generated and how they act to mediate gene silencing.
    ukcatalogue.oup.com/product/97...

ความคิดเห็น • 51

  • @marcusluong4586
    @marcusluong4586 9 ปีที่แล้ว +152

    Agreed with what most people here suggested, the narrator should speak a bit clearer and louder. But the content itself is very excellent. Thank you very much!

    • @hunglikehuang
      @hunglikehuang 6 ปีที่แล้ว +3

      Turn on the captioning. It's essential when there are dense jargon being thrown around.

  • @Randymanrockssocks
    @Randymanrockssocks 5 ปีที่แล้ว +58

    Thanks prof. Snape! I totally get it now!

  • @abm4952
    @abm4952 7 ปีที่แล้ว +4

    great review and animation. Need to have a basic knowledge of miRNAs and siRNAs to be able to fully appreciate this.

  • @BigManJay69
    @BigManJay69 8 ปีที่แล้ว +14

    This is actually very very good. If you don't understand it i recommend watching the simpler more basic videos on mi and siRNA's first. Then this will make more sense :)

  • @prakritirds
    @prakritirds 6 ปีที่แล้ว +7

    Nice animation and excellent explanation. For those who is getting problem with sound I suggest to use headphones, it is quite a clear sound.

  • @rickyroko1
    @rickyroko1 9 ปีที่แล้ว +10

    The accent might make it hard to grasp the informations, but to the video has an excellent quality. Thank you very much.

  • @ylhuang6144
    @ylhuang6144 7 ปีที่แล้ว +9

    i like this video! it solved my problem perfectly! open the subtitles would be helpful.

  • @CompBioQuest
    @CompBioQuest 6 ปีที่แล้ว +1

    Love the animational, beautiful!

  • @musicfanman94
    @musicfanman94 8 ปีที่แล้ว +23

    Awesome information! Broken down in detail and animation is great! I just could not understand the narrator from time to time!

  • @madelynnowak-roddy5121
    @madelynnowak-roddy5121 8 ปีที่แล้ว +2

    this actually helped loads, thanks so much :)

  • @ericabaker5295
    @ericabaker5295 7 ปีที่แล้ว +1

    beautiful video!

  • @BrokenTwistedPrince
    @BrokenTwistedPrince 6 ปีที่แล้ว +14

    Noteworthy: 100% homologous complementarity between the passenger miRISC* and target mRNA will result in endonuclease activity and mRNA cleavage, whereas asymmetrical RISC assembly with partial match will result in translational repression of mature mRNA.

  • @ds862
    @ds862 9 ปีที่แล้ว +15

    Beautiful animation, but in a completely silent room with my computer volume up to max, I can still only hear and make out 2/3 words that the narrator is saying. I unfortunately won't be able to show it to my AP Biology class with any great success. The narrator needs to speak louder into the microphone (and perhaps a bit slower, but the clarity will probably be helped if the volume of the video sound is increased.

    • @ds862
      @ds862 8 ปีที่แล้ว +3

      +violinsheets Last year I had students curious about siRNA and miRNA as they were mentioned in their AP Biology textbook. This would have been appropriate to help explain that section of their text for interested students. You're correct, though, in that it's not a standard focus point of the AP Biology curriculum. I don't think I have to be "high" to want to offer a little more detail for students who REQUEST IT and who will be entering into selective premed programs next year.

    • @violinsheetmusicblog
      @violinsheetmusicblog 8 ปีที่แล้ว +1

      Deanna Schnepp I was going to say... I thought you were making them memorize the proteins and complexes. Some of these things were only recently discovered like 10 years ago

    • @BigManJay69
      @BigManJay69 8 ปีที่แล้ว

      +violinsheets memorising all these would be a bit harsh yeh

    • @violinsheetmusicblog
      @violinsheetmusicblog 8 ปีที่แล้ว

      BigManJay69 welp I had to do it for my molecular biology course I was taking. so glad that torture is over

    • @BigManJay69
      @BigManJay69 8 ปีที่แล้ว

      spent so much time learning and memorising this whole procedure and NONE OF IT CAME UP IN MY EXAM TODAY! that is annoying, i had it down so fuckin well

  • @frankgomez7579
    @frankgomez7579 6 ปีที่แล้ว +1

    This is awesomme

  • @TanoMac73
    @TanoMac73 8 ปีที่แล้ว +8

    Narrators voice is not easy tun understand at times. Audio could be reworked for actual academic use.

  • @chunkilabhutia6721
    @chunkilabhutia6721 8 ปีที่แล้ว +30

    I can't understand...if the voice was clear it could be more interesting..!

  • @tiaanwest4905
    @tiaanwest4905 6 ปีที่แล้ว

    Thank you very much!!!

  • @Juicyvale14
    @Juicyvale14 6 ปีที่แล้ว +3

    very informative but why does his voice sound like Kevin Malone from The Office

  • @boaz411133
    @boaz411133 8 ปีที่แล้ว

    thank you!

  • @JOCELIOSANTOS_JTS
    @JOCELIOSANTOS_JTS 5 ปีที่แล้ว

    Please, enable the video to allow translation

  • @drcal7282
    @drcal7282 7 ปีที่แล้ว +1

    GREAT animation! #GRINDTIME

    • @mmaking8664
      @mmaking8664 7 ปีที่แล้ว

      Put that work in man and have self belief. U can do anything u want in life with #hardwork and #selfbelief and #discipline

  • @carolinejaqueline1727
    @carolinejaqueline1727 6 ปีที่แล้ว +4

    how the fuck am I supposed to remember all this

  • @nilanjandas3575
    @nilanjandas3575 5 ปีที่แล้ว +1

    Thank you infinitely for it.

  • @patrickdv1727
    @patrickdv1727 8 ปีที่แล้ว

    ps. and there are thousands of possibilities of different multible underfunctions include a proteine changer

  • @BalaBiologyWorld
    @BalaBiologyWorld 8 ปีที่แล้ว

    thanks sir......

  • @georgem.7539
    @georgem.7539 8 ปีที่แล้ว +8

    The narrator is not speaking clearly enough and he is like he is whispering.

  • @CellRus
    @CellRus 9 ปีที่แล้ว +18

    the video is very nice but the voice of the demonstrator is not very clear, i guess its the accent, so it makes non-native speaker like me hard to listen to! If you can choose a person with a better voice, it would be a very good and clear video.

  • @keanureaves2228
    @keanureaves2228 7 ปีที่แล้ว +1

    almost forgot to watch this today

  • @rubine24
    @rubine24 9 ปีที่แล้ว +2

    good video but too quiet......

  • @patrickdv1727
    @patrickdv1727 8 ปีที่แล้ว

    Inbuilding of a rso gain complex of a cannabinoid structure will change everything....think about it ;-)

  • @naadirahismail5797
    @naadirahismail5797 9 ปีที่แล้ว +10

    i can hear him clearly and im sitting in a library

  • @MoeMerkin
    @MoeMerkin 7 ปีที่แล้ว +2

    DAT VOICE THOUGH

  • @moocowbaasheep
    @moocowbaasheep 7 ปีที่แล้ว +1

    People complaining about the voice but it seems perfectly clear to me and my Spanish friend.

  • @beanage85
    @beanage85 7 ปีที่แล้ว +1

    The narrator sounds like Greg Davies...

  • @pipeyto7
    @pipeyto7 7 ปีที่แล้ว +5

    peanut butter mouth

  • @nanangs1077
    @nanangs1077 5 ปีที่แล้ว

    The narrator accent should be appropriate with this very nice video. Every body does not alway catch the voices. So please the voices of narrator should be clearer so easy to hear, if it intends to share this for learning or education. Anyway,Thanks.

  • @alissonrocha4836
    @alissonrocha4836 7 ปีที่แล้ว

    almost I dont understand this is video.

  • @robertaannibale1522
    @robertaannibale1522 7 ปีที่แล้ว

    ;)

  • @mirnaresendiz959
    @mirnaresendiz959 8 ปีที่แล้ว

    hi

  • @sobster123
    @sobster123 8 ปีที่แล้ว +2

    three words, too fekin complex!