Type II hypersensitivity (cytotoxic hypersensitivity) - causes, symptoms, & pathology
ฝัง
- เผยแพร่เมื่อ 21 มิ.ย. 2016
- What is type II hypersensitivity? Type II hypersensitivity is an immune response in which host cells are damaged due to antibodies binding to the cell surface. Find our full video library only on Osmosis: osms.it/more.
Join millions of current and future clinicians who learn by Osmosis, along with hundreds of universities around the world who partner with Osmosis from Elseiver to make medical and health education more engaging and efficient. We have unparalleled tools and materials to prepare you for success in school, on your board exams, and as a future clinician. Sign up for a free trial at osms.it/more. If you're interested in exploring an institutional partnership, visit osmosis.org/educators to request a personalized demo.
Follow us on social:
Facebook: osms.it/facebook
Twitter: osms.it/twitter
Instagram for med: osms.it/instagram
Instagram for nursing: osms.it/ignursing
TikTok: osms.it/tiktok
Linkedin: osms.it/linkedin
Our Vision: Everyone who cares for someone will learn by Osmosis.
Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: osms.it/mission
Medical disclaimer: Osmosis from Elsevier does not provide medical advice. Osmosis from Elsevier and the content available on the Osmosis from Elsevier properties (Osmosis.org, TH-cam, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed healthcare provider. Always seek the advice of a physician or other qualified healthcare professional with any questions you have regarding a medical condition.
© 2024 Elsevier. All rights reserved.
just a summary...so i can come back and revise too
Type 2 hypersensitivity
mechanism of action:
1.Activation of complement system: C1 binds to Fc portion of the antibody. Activated C3,C4,C5 - atrracts neutrophils, degranulation, cell lysis.
2. Membrane Attack complex - disturbance in osmotic gradient - cell lysis
3.C3 associated opsonization and phagocytosis
4. ADCC - antibody dependent cellmediated toxicity - NK cells
NONCYTOTOXIC MECHANISM: Antibody mediated cellular dysfunction.
eg..Graves disease, myasthenia gravis.
Come back and revise it for the 31st time. xD
I just love it when the neutrophil comes up and vomits all kind of enzymes and stuff .
yeah u r right🤣🤣🤣
Very creative 😅
I cant believe how specific these videos are. There's more detail in this video than there is in my lecture notes lol and I'm in second year of uni.
same
Have u graduated now dude 🤔😃
@@jemy_tube 😂😂😂
Are you a doctor now?
@@thephilosophersjourney2595hopefully
4:38 I adore the sound effect when the cell bursts, it's so damn satisfying!
These videos are so helpful that I feel bad for all the medical students who had to learn these materials without the Osmosis’ help. I feel very fortunate!!
I'm currently in medical school and am very happy that I found your channel! Thanks for simplifying so many topics in such simple ways!
Thanks, Whitney! We’re glad you like the videos. If you want to further enhance your medical studies, check us out on our website! In addition to having exclusive access unreleased videos (which include an 8-part series on ECG, a series on embryology, and unreleased videos on physiology and pathophysiology) Osmosis Prime members have access to thousands of board-style quiz questions and flashcards, study scheduling tools, and much, much more! Check us out here: bit.ly/2ut5ZEJ
You guys are awesome! Putting these videos together helps link everything we learn into a smooth progressive piece to remember and understand processes better. It makes the various lessons on a subject cone together into a whole. Thanks SO MUCH!
Thanks!
Please never stop making such amazing videos! Your videos are actually better than reading the notes. Just simple and understandable! You guys are outstanding! I always recommend watching your videos to my friends and they too really like it.
Thank you so much!
This really makes it so simple. Thanks a lot guys.
the visuals are amazing! great job:)
It was very helpfull!!! Also great, funny animations. Keep up the good work!
Thanks!
red blood cell : guys believe me i am on your side :(
the immune system itself is the imposter
People who make videos like this make this earth a better place. So helpful, thank you :)
Thank you so much for making these videos! They have just the right amount of depth without being overwhelming.
Thanks for the kind words, LAisyourgirl! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on TH-cam? Check it out here: bit.ly/2u35D6J
perfect videos,simply explaining everything,so easy to understand...good luck...
i love how the cells are mostly either looks innocent or make me pity them
I LOVE your videos. Really helpful than every page on the internet I combed through to find answers :D
Btw, just one thing. Myasthenia Gravis and Grave's disease are classified as Type V hypersensitivity now right? Functional disorders?
Best explanation of the topic in youtube. Thank you
This channel is genius! Thank you, this was very helpful
tomorrow is my immunology quiz and this video is verrrrry helpful! thank you so much guys :)
thank u so much , it is such an accomplished work .
Ammmmmazing .
Best video I’ve watch by far!! Thank you
wowow this is SUCH a good video ! Thankyou!
This is so helpful! Thank you
this is awesome, thank you so much for the videos !!! Really appreciate it !!
Really neat and helpful, thank you.
Can u plz make a vid for the complement system ?
Can't thank you enough. God bless you guys... You really really are a great help.
You are too good 😊 Thank you for this!
Give thanks to youpeople this video has really help me.ready to write my exams tomorrow
Thanks man! It was an amazing video!:)
Very cool! Helped me a lot! Keep up the good work.
OMG! i can't thank u enough this is great keep up the good work
well explained..I've come across this channel for the first time as it's a recently launched one..but I must really appreciate u people for both the quality quantity of videos you have put up..n the best part is that u give a broad overview of the topic in a short time using simple animations..this is especially going to help the students correlate and interconnect various topics..thank you..n keep going.
amazing Mann.. thanks for this
Thanks! It helps me!
guys u really made it easy god bless u
You guys are the best this was veryyyyy helpful and in only 9 minutes AWESOME ♥ THANK YOU endlessly
such good quality. thank you
These videos are so helpful
you guys dominated the lane, thnx
Really Great.....Easy to get the Point
thanks a lot guys,very very helpful :)
Very very useful video!
You are simply a genius
It was helpful thank you
excellent work.
thanks
Thanks!!
I like the summary part for quick review.
Great suggestion! We're going to look into doing this more often for future videos!
Nice explanation
Thanks
This video was SOOOOOOO GOOD! ¡¡OMG!!
It is absolutely perfect for who learns easier with visual objects and games.Thnx ozmos
True...at times having an example visually demonstrated helps so much.! SLAINTE N take care.👍
awesome work :):)
Thank you so much ❤️
Thank you so much
you are the best
DUDE!!!! You are the man! Taking Immunology and I swear my professor is leaving us high and dry. Thank you for breaking this down into easy to understand terms. You saved me my dude!
Always our pleasure to help! 🙌🏼
wow just wow!!! am in second year of university, persuing a pharmacy degree and am watching from zambia, africa......and personally this is the best detailed explanation of the the type 2 hypersensivity. am sure to follow up of the rest of the types and hopefully hope for more videos on pathology
Thank you Sir.
This channel helps to simplify a lot of difficult portions for me❤
Happy to hear that, Hasna! 😊
good tutorial...
This is awesome. Been staring at powerpoint slides trying to learn this forever before looking here and everything makes so much more sense now. Thank you for making veterinary school just a little bit easier!!!
THANK YOU
Thank you very much dear
Thank u so much 👍🏾
Very clear and well explained video !! Thanks a lot !!💪👌
Glad to help, Apelel! 💫 🥰 💖
Excellent 👍 Keep up working plssss
Thank you
Why there is one like to give for each video☹️ .. You guys deserve thousands 😍❤️❤️
please make a video about organ transplant rejection types
We will eventually! You can vote for upcoming videos by becoming a Patreon subscriber. www.patreon.com/osmosis
Thank you 😍
i fell in love with the cute cells illustrations in this video..haha.. it is really helpful BTW.
You are great!
your videos are AWESOME. English is not my first language and I'm studying medicine and I didn't understood my proffesors video but I did with yours! THANK YOU!
Glad to help, Juliana! 💫 🥰 💖
Couldn't be better than this. Just Wonderful !!
Glad you like it!
You are awesome thankyou so much for making these videos very helful
Thanks for watching, Saba! We're glad you're finding our videos useful. If you haven't yet checked out our educational platform we have a bunch of tools that we think you'd like. These include unreleased videos, tens of thousands of flashcards and multiple-choice practice questions, study workspaces, and daily exam schedule organizers to help you learn medicine. You can sign up for a free trial of Osmosis Prime here: bit.ly/2ut5ZEJ
Itz really good to watch....
شكرًا 💕
thanks
Thank youuuuu ❤️❤️❤️❤️❤️
wht a nice vid , thanks
I love your videos. Could you tell which programm do you use to this? I´ve got to do one similar for my inmunology class
Thank you Osmosis 👏
Our pleasure, Rukiee! 😊
you are the best !😍😍😍 thank u so much
Thanks for the kind words! It would be awesome if you and your friends could review us on our Facebook page. facebook.com/pg/OsmoseIt
Thank you so much for making such useful videos. After seeing these videos topics seem to be very easy.
You are most welcome, Kherde! Glad to help! 😊
very helpful
Lordy... I love these videos.
merci beaucoup _ thanks
thanks for the video, is there a very distinct summary comparison between type 1-4. i have watched the 4 video however i just couldnt really distinguist them as basically they all involve with antibody, etc
excellent work !
Thanks!
Very easily explained....
Thank you, Safoora! If you’re interested in getting early access to our videos, check us out on Facebook: bit.ly/2u35D6J, or, even better, get exclusive access to dozens of our unreleased videos now at our website: bit.ly/2ut5ZEJ.
Great videos .thanks alot.
Can one help me ,I a'm confused!
Is there difference between mechanism one and three , aren't both of them opsonization?
Pls any video on type IV
excellent!!!!!!!!!!!!!!!!!!!!!
you're best!
Love love looooveee your videos ! They are so helpful ! But would you maybe be so kind to talk a bit slower, for the non-native english speaking students ? Thank you in advance !
Plz make videos on all topics of patho.
thanks alot
you are awesome mate keep up the good work
Thanks so much! It would be awesome if you could review us on our Facebook page. facebook.com/OsmoseIt/
Thank you for this 💗
You're welcome! 💖 💖 💖
You guys are great, I have a friend of mine that is always recommending you to me and here I am, listening to his advice. Just wanted to drop this comment about 3:00, the complement proteins (C1q) does not bind to the Fc portion of the antibody, rather it bind to the antigen binding side which is found on the constant region of IgG and it is above and different than the Fc portion.
Can you share with us a credible source that supports the correction? Thanks!
Hello, I just double checked from many journals articles, what you have said is true. The Fc portion on an IgG is divided into two compartments, upper one for complement and lower one for membranes or receptors. Thanks for your reply.