Signal Transduction Pathways (G-Protein, Receptor Tyrosine Kinase, cGMP)

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[@DirtyMedicine]

The mnemonic for G-Protein Coupled Receptors could be improved by writing "Go to AC for Craps and Poka". Poka (as opposed to Poker) helps remember PKA even better! Credit to Meryl Braun for the idea!

[@Mohamedyasar1234]

Super explanation sir

[@David-ys1dt]

you da man
God bless bro

[@balkiszaitoun3051]

or just read it in a british accent haha

[@Sweetlynah]

I just noticed Dopamine wasn't included as a GPCR! It affects Gs (b1), Gi (a2), and Gq (a1) as well as D1 and D2 receptors. I'm still trying to understand more of its effects though

[@cytozy6809]

The amount of joy it brings me when I look up a concept on TH-cam and see that you have a video on it is immeasurable. I just know that a concept that I was struggling with is going to suddenly become way more understandble 💖

[@hehateme1187]

I just spent a half hour looking at this page in First Aid completely lost. I could kiss you right now.
you had NO business going this hard 😩🔥

[@laurabou1244]

omg where on the FA (page/ FA year)?

[@hehateme1187]

@@laurabou1244 They barelyyyy talk about it. It's ridiculous. Page 337 in the 2020 edition.

[@yourfuturedocburenbeiya]

Love your channel & you deserve a million+ followers!! I couldn't thank you enough!!

[@DanielaHernandez-wr3cl]

I SPENT AN HOUR TRYING TO UNDERSTAND THIS USING MY PROFESSORS LECTURE AND NOTES AND BY THE END I WAS STILL CONFUSED. BY WATCHING THIS VIDEO I UNDERSTOOD RIGHT AWAY. THANK YOU SO MUCH FROM THE BOTTOM OF MY HEART REALLY

[@aleenamasroor436]

Thank you so much. I never understood this for first two years of med school. Finally today I needed to understand this for pharmacology and YOU somehow sprinkled sense into it. THANKS A LOT ONCE AGAIN.

[@anglaismedical5573]

We should call you Dr Big Picture! Thanks a million! I can never thank you enough for simplifying what seemed un-understandable

[@sparkles2345]

OMG Thank you!! What my professor couldn't teach me in 1 month you taught me in 17 minutes!!

[@MoeKyawThu86IM1]

Thank you for your clear explanation. Just for the fact, i like to point out that MAP-kinase-kinase-kinase is called Raf, MAP-kinase-kinase is called Mek and MAP-kinase is called Erk. (You mentioned MAP-kinase-kinase-kinase controls Raf and so on at time 13:20 to 13:27).

[@adeelsajid995]

OMG this is god sent!! Was in dire need of this!

[@tatius2457]

Oh my god, I was just stating how I wish there was a video on this, thank you so much step in 4 weeks!

[@tatius2457]

came back, 1.5 weeks. prayers please

[@CXY96]

How did it go? Any surprises?

[@anianoelle7033]

i literally just decided i was going to take the Ls on these questions, and then BOOM! Dirty saves the day 🥳bring on the signal transduction q's IM READYYYYYY 😤

[@Be1smaht]

Why take an L on anything dude?

[@Be1smaht]

Get those pts. You know like 20 questions is the difference between like 50 points lol

[@Be1smaht]

This is game day baby! Stay hungry

[@DRABENIDRLIDU-eh9yx]

Interesting presentation .Thank you so much .

[@roseo3731]

Thank you. You did an amazing job

[@michaelekun3175]

Hello! Thank you very much Mr dirty for this video it really helped me break down this complex topic uno something easily understandable with extra learning and I am hoping to see a topic on : apoptosis and necrosis on day arigatou go sai ma su and may God bless you😁

[@TanyiaDadbin]

So so grateful for your videos

[@hoang9682]

It's comprehensive !
Thanks a lot

[@obioraokafor831]

still doesn't get old. thanks

[@mutazomer9143]

it is important video for medical student, it,s help full and give good idea about signal transaction.

[@AnaH-qu1eh]

BLESS U FOR MAKING THIS!!!! my exam is in two weeks!

[@alvarosoria8787]

just what i neeeded!!! thank u

[@marziasahebzada4096]

Brilliant video! 👏👏👏👏👏

[@paulakuper6998]

Hey! Thank you for your biochemistry videos they helped me a lot last semester. I wish you could do more videos like this one because it appears now in my molecular biology course and only you can save me from this awful course 🙏🏻🙏🏻🙏🏻

[@blackbeltendcrinology]

Thank you so much Dirty!!

[@ambreensabah3758]

Thank you so much....you are blessing👍😀

[@__-lo7yt]

OMG thank you sooooo much！！！
Really appreciate your help.

[@prestigehilary]

I don't comment on videos often, but damn.... thanks, man!!! ❤

[@rufinamenezes7712]

Thank you very much for your video. It was very helpful

[@user-te1vn8tk8e]

"any financial support will help but if you dont donate im still going to make free videos anyway. ", this guy is legend

[@igornarciso2666]

Great video! thank you for that!

[@jon105]

Thank you! Very helpful!

[@pallavir4822]

Thank you so much sir . It was very helpful video 🙏🙏

[@carolinaferraz255]

awesome video!

[@t-alimichael3363]

..and my Phd professor making 6 figure income couldn’t explain it in 2 hours lecture-shame. Bless you Sir!

[@hamzaanees2811]

The only video on this topic that I like

[@grahampankratz2243]

Step in three days. Perfect timing, Dirty!

[@prestigehilary]

15:45 so you end on a high note and feel like you dominated this video 😂😂. Reminds me of Yuval Harari's book, Homo Deus and all the talk about our biochemistry there.
Thanks for the great video ❤

[@drshridevirohinashetty6085]

Thank you so much for this video

[@milaroiron4158]

you saved my life thank you

[@bisolailias3820]

Excellent.

[@gregoriocassini6620]

thank you this video was amazing

[@xaaboopinkly]

Huge thanks sir!

[@snehjitbose]

Thankyou Sir.. much obliged 😀🙏🏻

[@areejkhatib9095]

Great one!

[@noufalnasser568]

Nice work

[@solsoblue2297]

Dirty, T_TI love you so muchhhhhhhhhh. You save me from a mess!!!
finally!!!

[@dickensochieng3256]

Superb

[@curiouscat1487]

I LOVE THIS!!!!

[@albaraahariri7009]

You are the best bro

[@proghostlee2795]

Wow! This is my tomorrow exam's test content!

[@parisarezvani4012]

Thanks for this great video, but as a question,Angiotensin2 signaling
doesn't work through Gs?

[@HankFuller333]

Thank you!

[@asisababun7543]

Thanks!

[@KinzaHussain]

Wow I've been needing a mnemonic for thisss! Thank you!!! Do you have a video on the Heme synthesis pathway & porphyrias? I haven't found it and I can't think of a mnemonic! I always forget the steps for this pathway!

[@DirtyMedicine]

Not yet, but it's one of the videos in my queue that should be coming soon. I've already done some of the slides

[@Womanhu]

He does now baby!!!

[@kokocipher]

finally a video that connects Ras w/ Receptor TK.

[@Painsurb]

Thank you so much 😊

[@nabimanyaconrad9811]

thank you so so much🙏

[@cayladoo_1]

amazing!

[@fatimasuleman1980]

Thank you so much

[@3catsand3humans]

Thanks a million… you just saved my brain😂😂

[@BellaVevo08]

You are amazing

[@dikshantjha]

Thank you!!!!!

[@lukekintsukuroi2383]

neat and tidy! cheers, my duuude.

[@youssefhamdy6008]

I promise I'll donate frequently once I get a job

[@ginamarie7603]

Thank you

[@priyankarait3733]

Ras is activated by grb+sos
Gdp - gtp is used in gpcr but in rtk it's different 😬😬

[@monisiay]

I love this video

[@esraakhamees986]

Thank u soo pretty much

[@Be1smaht]

Good video

[@-REYO-]

Thank you that is greaaaaaat

[@Soriyou3]

Thank you so much for this video. Can you please make a video on genetic/molecular markers for cancers? Also a video on general immunology would be helpful. Thank you.

[@rahulsadhumbbs5124]

Best taught by najeeb sir

[@anaos1004]

Yaay I asked for this! Thank you!! 💕

[@PrideofPitchers]

hey, you have a nice picture like me :) twinsies

[@anaos1004]

@@PrideofPitchers oh gosh, that’s right 😂

[@yusra5833]

THANKYOUUUUU

[@dannyd9964]

You didn't talk about non receptor tyrosine kinase (the Jak/stat) which is driving me insane. Please help

[@babahuusain9828]

See medicosis Perfictionalis he explained this top clearly…. JAK GET PIG😂

[@PS-pr5py]

all killa no filla! thanks!

[@AmiirSh]

nice bro

[@renjuraju6054]

super

[@songohan393]

thanks

[@ttareeqq20]

the best

[@lukehumphrey1911]

I thoughts ras was activated by GEF which is activated by SOS bound to grb2 which is bound to the rtk

[@sm4887]

thank uuu

[@tariqtariq3208]

thanks you. do you have any good way of remembering the hormones related to each pathway

[@actionman4593]

For IP3 mediated: GOAT HAG:- GnRH, Oxytocin, ADH V1, TRH, Histamine H1, Gastrin
For cAMP: FLAT CHAMPs CHuGG:- FSH, LH, ACTH, TSH, CRH, Histamine H2, ADH v2, MSH, PTH, Calcitonin, hCG, Glucagon, GHRH

[@koushikkarthikeyan156]

@@actionman4593 legend

[@kim_398]

Any video on cytokine receptors and jak/stat pathways

[@sashak6798]

MY MAN!!!!!!!!!!!!!!!!!!!!!!!!!!

[@glenngillpineda6670]

is there a chance that I could get your presentation?

[@drkaymd]

Saviour saviour 💕💕💕💕💕💕💕

[@Afterburningyou]

Also, keep in mind everyone that:
- increased levels of GTPase = decreased Gq/Gs/Gi activation.
- if they talk about activation of a G-protein followed by a phospholipid cleavage = Gq pathway

[@kikithepupper6774]

when I can't remember the Gas activates the Adenyl Cyclase pathway, I think of that song GAS GAS GAS I'm gonna STEP ON THE GAS, which gets the adenyl cyclase pathway going...

[@openyourmindtomedicine]

"That is a defeatist attitude" :')

[@TheZFHaters]

YES KING

[@Chelsea-gs7qj]

What about the signaling pathway for ACH?

[@khushwindersingh5244]

Yesss!!!!!

[@AgustinaArce-ne2lt]

I wish i could make my own medical school and hire you as a professor

[@mohammedalrubaiaan9138]

a mnemonic for the substrates was literally layed out for us, I dont know if he didnt mention it because it was obvious and everyone knows them or if it was seriously missed. its the first letter of all substrates in the same order he had in the video
for G protein coupled receptors Gs and Gi the substrates are: FLAT CCHHAMP GG. or FLAT CHAMP cggh (pronounced sugah) the 2 Gs can remind you that its Gs AND Gi and the theme of things in pairs of 2 should remind you that its H2 and ADH V2
for Gq: GOAT HAG , there is only 1 goat so its linked to V1 and H1
for RAS: remember its associated with growth and insulin is an anabolic peptide + Growth factors. letters are random IIPFE
cGMP; its associated with dilators as he mentioned. NO ANP BNP and Endothelial derived RELAXATION factor are all dialators

[@JPlus-qm8je]

I thought ERK is MAP Kinase? So MAP kinase kinase controls the phosphorylation of ERK because it is the kinase for MAP kinase.

[@babahuusain9828]

For Non Receptor Tyrosine Kinase pathway(JAK STAT)
see Medicolis PERFICTIONALIS

[@danjbro]

But Diiiiiirty! I love it - great work! 😆 🤣 😂 ⚰

[@nived8476]

His Mickey Mouse-sounding impression of us is spot on lol

[@doctorposting]

which protein does serotonin use?

[@YourIMGguru]

but what about janus kinase receptors? Jak-stat?