Neuroinflammation, Pain, and Fatigue Lab at UAB
Neuroinflammation, Pain, and Fatigue Lab at UAB
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048 - Treating chronic low back pain with noninvasive vagus nerve stimulation
Here is a new pilot clinical trial for managing chronic low back pain. You can find the full paper at: www.mdpi.com/2077-0383/13/24/7601
- Jarred Younger
มุมมอง: 2 325

วีดีโอ

047 - Intranasal antihistamines may prevent Long-COVID
มุมมอง 4K21 วันที่ผ่านมา
Here is the link to the open-access paper. You should be able to access it by clicking on the PDF button: pmc.ncbi.nlm.nih.gov/articles/PMC11600942/ - Jarred Younger
046 - Does oxaloacetate reduce ME/CFS fatigue?
มุมมอง 3.8Kหลายเดือนก่อน
New results from a ME/CFS clinical trial. You can find the complete paper at: www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1483876/full - Jarred Younger
045 - Can we filter ME/CFS and Long-COVID out of our blood (apheresis)?
มุมมอง 4.7Kหลายเดือนก่อน
Two new pilot studies indicate that therapeutic apheresis may be helpful in controlling ME/CFS and Long-COVID symptoms. The published report can be found at: www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2445-8593 - Jarred Younger
044 - Inflammation and anxiety
มุมมอง 3.6Kหลายเดือนก่อน
After I did a video on inflammation causing depression, I was asked if inflammation can also cause anxiety. Here is the answer from work conducted by me and other research groups. - Jarred Younger
043 - New paper published! Air quality affects pain and fatigue.
มุมมอง 1.9Kหลายเดือนก่อน
Here is our new paper on air quality and chronic pain and fatigue. Just click the download button at: www.mdpi.com/1660-4601/21/12/1560 The real-time air quality map I used for this presentation can be found at: www2.purpleair.com/ . You can click on one of the map links on that page. - Jarred Younger
042 - Cognition really is worse in ME/CFS
มุมมอง 4.3K2 หลายเดือนก่อน
A new scientific paper shows impaired cognitive functioning in ME/CFS. While this will not be a surprise to anyone with the condition, the study helps us understand the nature and extent of the problem. You can find the open access full paper here: pmc.ncbi.nlm.nih.gov/articles/PMC11565701/ The thumbnail image uses the Neurotorium brain atlas: neurotorium.org/tool/brain-atlas/ - Jarred Younger
041 - Thanks to all the Veteran research participants
มุมมอง 7062 หลายเดือนก่อน
It is Veterans Day in the U.S., and Armistice Day or Remembrance Day in many countries throughout the world. I thank my funders and research team for all their support, and in particular thank the Veteran research participants who give their time to help us discover new treatments. - Jarred Younger
040 - We need to talk about C-Reactive Protein (CRP) a bit more
มุมมอง 4.3K2 หลายเดือนก่อน
As promised, here are the new data on systemic inflammation in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). - Jarred Younger
039 - We need to talk about C-Reactive Protein (CRP)
มุมมอง 8K3 หลายเดือนก่อน
C-Reactive Protein (CRP) is a sensitive marker of inflammation. I am presenting some new data on CRP elevations I see in chronic pain and fatigue conditions. - Jarred Younger
038 - Update on clinical trials for pain, fatigue, and cognitive issues
มุมมอง 3.8K3 หลายเดือนก่อน
Here is a quick update on our current clinical trials. Below are screening links for our psilocybin (for fibromyalgia) study and curcumin, stinging nettle, and resveratrol (for Gulf War Illness) study: Screening link for psilocybin and fibromyalgia study: uab.co1.qualtrics.com/jfe/form/SV_20jbBUG5kx7bLBI?S=Y Screening link for botanicals and Gulf War Illness study: uab.co1.qualtrics.com/jfe/for...
037 - NIH needs your Long-COVID treatment suggestions
มุมมอง 3K3 หลายเดือนก่อน
The National Institutes of Health's RECOVER-TLC (Researching COVID to Enhance Recovery - Treating Long COVID) initiative is collecting treatment ideas to prioritize for clinical trials. If you have experience with an intervention that helped Long-COVID, please submit the information at the site below: fnih.org/our-programs/accelerating-covid-19-therapeutic-interventions-vaccines-activ/recover-t...
036 - Elevated adrenaline in ME/CFS
มุมมอง 8K4 หลายเดือนก่อน
This recent meta-analysis found that individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may have elevated adrenaline while people with fibromyalgia (FM) do not. - Jarred Younger
035 - A new clinical trial for ME/CFS (LIFT)
มุมมอง 4.7K4 หลายเดือนก่อน
The Open Medicine Foundation (OMF) has started a clinical trial of low dose naltrexone (LDN) and pyridostigmine bromide (PB) for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In this video, I discuss the details and my impressions of the study design. More info can be found at the links below. The ClinicalTrials.gov site: clinicaltrials.gov/study/NCT06366724 The OMF signup page: ...
034 - My list of potential treatments to test
มุมมอง 6K4 หลายเดือนก่อน
If you were curious about the compounds I plan to test for ME/CFS, FM, GWI, and Long-COVID, here is my full list! These are chemicals that may return microglia to their normal state and reverse chronic brain inflammation. - Jarred Younger
033 - Updates from the 2024 Stanford ME/CFS Working Group
มุมมอง 8K4 หลายเดือนก่อน
033 - Updates from the 2024 Stanford ME/CFS Working Group
032 - A new clinical trial for fibromyalgia using EMDR
มุมมอง 3.5K4 หลายเดือนก่อน
032 - A new clinical trial for fibromyalgia using EMDR
031 - Air Quality Can Affect Chronic Fatigue and Pain
มุมมอง 3.7K5 หลายเดือนก่อน
031 - Air Quality Can Affect Chronic Fatigue and Pain
030 - Does ME/CFS involve low brain oxygen?
มุมมอง 6K5 หลายเดือนก่อน
030 - Does ME/CFS involve low brain oxygen?
029 - We need research on severe ME/CFS now
มุมมอง 5K5 หลายเดือนก่อน
029 - We need research on severe ME/CFS now
028 - New findings: more evidence of poor oxygen perfusion in the brain.
มุมมอง 22K5 หลายเดือนก่อน
028 - New findings: more evidence of poor oxygen perfusion in the brain.
027 - New lab results - low brain oxygen in chronic disease
มุมมอง 21K6 หลายเดือนก่อน
027 - New lab results - low brain oxygen in chronic disease
026 - What clinical trials are happening now?
มุมมอง 2.2K6 หลายเดือนก่อน
026 - What clinical trials are happening now?
025 - How a virus damages our sense of smell.
มุมมอง 1.7K6 หลายเดือนก่อน
025 - How a virus damages our sense of smell.
024 - Can French maritime pine bark help pain and fatigue?
มุมมอง 6K6 หลายเดือนก่อน
024 - Can French maritime pine bark help pain and fatigue?
023 - Inflammation causes depression
มุมมอง 11K6 หลายเดือนก่อน
023 - Inflammation causes depression
022 - Resveratrol for inflammatory body pain
มุมมอง 5K7 หลายเดือนก่อน
022 - Resveratrol for inflammatory body pain
021 - The brain's inflammation thermostat
มุมมอง 16K7 หลายเดือนก่อน
021 - The brain's inflammation thermostat
020 - Research priorities for the second half of 2024
มุมมอง 2.3K7 หลายเดือนก่อน
020 - Research priorities for the second half of 2024
019 - Stinging nettle for chronic pain
มุมมอง 4.1K7 หลายเดือนก่อน
019 - Stinging nettle for chronic pain

ความคิดเห็น

  • @jennyandersson5682
    @jennyandersson5682 วันที่ผ่านมา

    Thank you for this explanation! It is definitely the most clear and straightforward explanation of both long covid and LDN as both are rather difficult and complex to explain and comprehend.

  • @Linnette-xb2bc
    @Linnette-xb2bc 2 วันที่ผ่านมา

    Hi Jarred. I’m interested in immune modulating drugs like hydroxychloroquine and immunoglobulin but also even more in glatimer acetate and interferon. Please if you could on day speak on your thoughts of these treatments. Also maybe try and guess what subtypes it could suit. I personally don’t have a clear infection trigger or problems with herpes. Also I guess immune function can be affected by other traumas such as psychological, physical, and intoxication. Not only infectious viral attack. 🌻

  • @amysin963
    @amysin963 2 วันที่ผ่านมา

    Some U.S. long haulers have traveled to Germany to try this. One I know of had a severe relapse of symptoms after and his docs back here in the U.S. had to treat to get him back to baseline.

  • @nowhereman8374
    @nowhereman8374 2 วันที่ผ่านมา

    Dr. Younger, since OAA is influencing the mitochondria, do you think that to improve the quality of the study, the researchers should control for hyperinsulimia?

  • @wendyhay1302
    @wendyhay1302 2 วันที่ผ่านมา

    I started with a nutmeg drink at night to help improve sleep. I have had long covid for almost 5 years. My main symptoms are dysautonomia. I have been amazed at the positive affect on my sleep, not only in quantity but also deep sleep quality. I see that nutmeg does contain oxalate, as do cloves and cinnamon. It would be worth adding these spices to the diet.

  • @cherylsmith2531
    @cherylsmith2531 2 วันที่ผ่านมา

    I had problems sleeping on naltrexone would I experience similarly this effect on dexa naltrexone?. She's

  • @strawberrygirl8572
    @strawberrygirl8572 3 วันที่ผ่านมา

    Is there an efficient way to get OAA from food instead of a supplement?

  • @lonnie5319
    @lonnie5319 3 วันที่ผ่านมา

    or just use the recorder in the phone lying next to you all night, it will give you the answer

  • @allfly2689
    @allfly2689 4 วันที่ผ่านมา

    Hello Jarred, Is it possible that tVNS like this would help drive down neuroinflammation in the brain by affecting activated microglia? As vagal tone seems to be low in CFS patients

  • @Icy_Death.
    @Icy_Death. 4 วันที่ผ่านมา

    Any news in obtaining fractalkine for injection yet?

  • @cherylsmith2531
    @cherylsmith2531 5 วันที่ผ่านมา

    Dr a while back you talked about a paper a journal a scientific study that looked at where the in the brain in the central nervous system is fibromyalgia where is it What part of the brain does it affect. Can you please send me the paper the name of the paper? Thank you so much

  • @TheNibor9
    @TheNibor9 7 วันที่ผ่านมา

    The decimal to the right? I had 24.4 mg/L, so that’s 244 mg/dl?

  • @johnathanabrams8434
    @johnathanabrams8434 7 วันที่ผ่านมา

    Palpating for myofascial trigger points in the erector muscles, quadratus lumborum, the psoas attachment at L5 and L4 and even myofascial trigger points in the rectus abdominis can refer pain to the lower back. Dry needling is the most effective treatment for myofascial pain syndrome. Myofascial pain syndrome is the most common manifestation of chronic pain there is. Combine the dry needling with electrical stimulation of the muscles, stretching and heat and you can reverse chronic pain conditions.

    • @oliverbird6914
      @oliverbird6914 7 วันที่ผ่านมา

      @@johnathanabrams8434 I've done the palpation stuff...it seems there are sympathetic nerves there that release stuff in the torso and back. I get a lot of relief from that but it's a stop and the benefit stops. Great rescue remedy. Perhaps if I was less ill, it would be transformative. Moving that fascia and trigger points seems very helpful. Thank you for verbalizing this

  • @shawnshawn7477
    @shawnshawn7477 9 วันที่ผ่านมา

    Dave Asprey talks cfs and mold th-cam.com/video/muAC7WXba4w/w-d-xo.htmlsi=mqAfHGs-DmKdug6n

    • @oliverbird6914
      @oliverbird6914 8 วันที่ผ่านมา

      @@shawnshawn7477 mold is a definite driver...but it's not the causal issue in my opinion. It's a downstream reaction to a phenotype. Some people are completely resilient to mold. Others just have to look at a damp wall and they're in bed! People have success with hyperbaric therapy and red light sauna. But why is it happening in the first place? Faults in the connective tissue. Asprey has autism I believe. Not uncommon amongst mold sufferers. I think mold is creating MCAS storms and provoking a huge immune response. Inflammatory Cascades. But why are those damn mast cells so eager to degranulate?

  • @juniperpansy
    @juniperpansy 9 วันที่ผ่านมา

    Aren't all the measurements the same within statistical error?

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      The actual tests they ran are two-sample t-tests contrasting the baseline condition with each timepoint. The main figure using a box-and-whisker plot with interquartile ranges doesn't really represent those tests very well. The 1 month and 3 month timepoints had lower reported back pain than baseline, with p-values below 0.001. - Jarred Younger

  • @paulgrandjouan3777
    @paulgrandjouan3777 9 วันที่ผ่านมา

    @youngerlab , did you get an answer in regards to the lack of statistics for the improvement in symptoms ?

  • @jimlee2664
    @jimlee2664 9 วันที่ผ่านมา

    Dr Nogier the pioneer in Auricularherapy. It worked for me to stimulate the low back area

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      Thanks for mentioning it. I haven't followed that treatment approach, but needles in the right area of the ear would affect the vagus nerve, so I can see the therapeutic benefit. There are many papers on that approach. - Jarred Younger

  • @shawnshawn7477
    @shawnshawn7477 10 วันที่ผ่านมา

    Lol. Why not fix the actual problem? Many countries use ozone and stem cells. Instead "our smartest people" are presenting this nonsense.

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      I don't do stem cell research, but I see the increasing number of scientific papers testing the approach for low back pain. The FDA has been slow to approve stem cell treatment, so I guess people have to go to other countries, unless they can be enrolled in a clinical trial. - Jarred Younger

  • @MissLibertarian
    @MissLibertarian 10 วันที่ผ่านมา

    I was having heart palpitations along with little muscle spasms in the chest wall that were mild, intermittent, and moved around (e.g., left armpit then right). I suspected a nerve issue, so when Dr. TH-cam showed me a vagus nerve video which also explained my acid reflux and neck and shoulder tension, I watched what it does. I got some relief from my (real doctor) chiropractor. Stress and bad ergonomics I know are recurring issues for me. Then Dr. TH-cam showed me some vagus nerve “reset” videos. The first one I tried ended these issues except for occasional acid reflux. It consisted of looking all the way to the right (neck and head neutral, eyes to the right only) and holding it for 30 seconds. And that was it: the original issues have not come back (palpitations, muscle twitches still gone). Other “reset” videos showed up and were as simple as taking 30 inhale/exhale breaths in a row. That seemed to help as well, sometimes, as I’ve tried these for any tension or stress symptoms I might detect. I know many energy practices (massage, acupuncture, acupressure, and others) use the ear to communicate with the nervous systems. But it was that vagus nerve that helped tie things together which is why I worry about seeing specialists instead of generalists. Everything may be connected!

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      Interesting! I agree that using the reductionist approach too quickly, especially with poorly understood chronic conditions, can cause us to miss the big picture. - Jarred Younger

  • @Aquasawagigi
    @Aquasawagigi 10 วันที่ผ่านมา

    Its the best time of the week once again!

  • @hookedonherbs3825
    @hookedonherbs3825 10 วันที่ผ่านมา

    I use a couple different devices I have touch point and pulseto both do have some benefits. They aren’t a cure but a good help.

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      Thanks for mentioning them. I haven't tried out any of those devices because they generally aren't tested scientifically for efficacy and safety. - Jarred Younger

    • @hookedonherbs3825
      @hookedonherbs3825 9 วันที่ผ่านมา

      @ they were affordable and I could return. Desperation experiments that helped.

    • @hookedonherbs3825
      @hookedonherbs3825 9 วันที่ผ่านมา

      If you haven’t research L rueteri dairy ferment. Microbiom repair please look into it. I am extreme chemical sensitivity. Back in 2016 when I started my natural journey I was mostly bed ridden, 280 pounds of massive inflammation, off the pain chart. I Could be on feet 90 minutes total in a day with walker. Now I am down 140 pounds and able to walk 10,000 steps a day. I make everything that goes in or on my body. 8 years of experiments have helped me regain much function. This recently found treasure stopped 2 mo tha of diarrhea, triggered from a visit to a medical facility and perfumes. 3 days my gut cleared. Gut feels better than anytime o can recall in 67 years. I was put on antibiotics as a tiny baby and have never had a well functioning gut. I am blown away what 2 weeks has done. And to be fair this may be the last piece of my puzzle where it may be an early piece for many. Dr William Davis MD author of Super Gut is where I found this experiment. Because like you when you have no answers experiments are only way to figure it out . Thanks again for what you do.

  • @furiousdoe7779
    @furiousdoe7779 10 วันที่ผ่านมา

    Ive just been visiting for the first time for a lasertheraphy L4/L5 ... radiating pain at the foot.

  • @cyber5515
    @cyber5515 10 วันที่ผ่านมา

    So, I guess the antihistamine stops the immune system from freaking out and attacking things that it shouldn't. So, if that is the mechanism then any good antihistamine should work.

  • @debh5780
    @debh5780 10 วันที่ผ่านมา

    Glad to see non-invasive alternatives being addressed for low back pain. Allergies to many antibiotics keeps me away from invasive routes so I hope this is an accepted treatment soon. 😊

  • @JamesH-oj1ly
    @JamesH-oj1ly 10 วันที่ผ่านมา

    It's great he's talking about Cns back related issues, as someone with Arachnoiditis I am starting to see how many individuals suffer with issues that step from chronic inflammation stemmimg from the cns system, it is said many issue's related to Fibro are cns issues

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      Thanks. I want to see if taVNS can reduce the brain inflammation I am seeing in the PET and MRI scans. - Jarred Younger

  • @oliverbird6914
    @oliverbird6914 10 วันที่ผ่านมา

    Appreciate the work. Jarred. I think this may be a non starter tho...this sortve stuff has been tried loads. Tens machines etc. Central sensitization. That's too much of an easy catch all phrase. IF it exists, it needs to be studied. I believe pain is a massive mcas issue

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      My main interest in VNS is that it seems to decrease inflammation in the central nervous system. It is hard to get pharmaceutical anti-inflammatories through the blood-brain barrier, so I want to know if VNS might be an alternative approach for some people. - Jarred Younger

    • @oliverbird6914
      @oliverbird6914 8 วันที่ผ่านมา

      @youngerlab sure jarred, I'm not trying to be negative. Leave no stone unturned etc but this to me is a very " du jour" therapy that won't stand the test of time. Perhaps hyperbaric oxygen therapy is a more realistic way of bringing inflammation in the brain down

    • @oliverbird6914
      @oliverbird6914 8 วันที่ผ่านมา

      @youngerlab there's some quite interesting work on the tongue being done and the lymphatics. You can invoke the parasympathetic response by realigning your tongue ( and therefore the structures the vagus nerve ebbervates)

    • @oliverbird6914
      @oliverbird6914 8 วันที่ผ่านมา

      @youngerlab I really suggest looking at thynoqinone too. That's instant albeit temporary relief

  • @bryanevans1019
    @bryanevans1019 10 วันที่ผ่านมา

    I wonder if the pain relief benefits are more from the muscle relaxation from the vagus stimulation, vs a lack of pain relief for skeletal related pain from disk disease, arthritis, etc?

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      Yes it could be that the decreased sympathetic drive would reduce muscle tone and relieve some types of low back pain. - Jarred Younger

  • @bitegoatie
    @bitegoatie 11 วันที่ผ่านมา

    On the other hand, the classic approach has a significant risk of serious injury to the patient. If this device can provide a fraction of the best-case benefit of the invasive method, without the worst-case risk, it is worth further investigation. Which is more or less the gist of the video.

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      Yeah, I guess if I were going that route, I would try noninvasive first. If that was working, but just not enough, I might consider invasive VNS. But I would have to try many other things before I had implanted leads. - Jarred Younger

  • @ClaireCaoimheRaeMoonshadow
    @ClaireCaoimheRaeMoonshadow 11 วันที่ผ่านมา

    There is a group on Facebook where a woman used this type of nerve stimulation for her chronic illness. It’s something I’ve been interested in.

    • @SunshineGrove04
      @SunshineGrove04 10 วันที่ผ่านมา

      May I ask what the group is called?

    • @ClaireCaoimheRaeMoonshadow
      @ClaireCaoimheRaeMoonshadow 10 วันที่ผ่านมา

      @@SunshineGrove04 AVA A Vagus Adventure

    • @hookedonherbs3825
      @hookedonherbs3825 9 วันที่ผ่านมา

      @@ClaireCaoimheRaeMoonshadow I have been experimenting with all the vagus nervous stuff for a couple years now. I do humming, tapping, singing through the day. I have two different devices they both seem to provide some relief. The touch points have I use daily. And anytime I have to go out and get all the toxic exposures. They have not been cure but my reactions is noticeable less sever when wearing them.

  • @minahana1112
    @minahana1112 11 วันที่ผ่านมา

    Thanks!

  • @gerardburns2500
    @gerardburns2500 11 วันที่ผ่านมา

    NMN Nicotinamide Mononucleotide i was wondering if it might help M.E.CFS. insomnia?. also, did you get the Garmin app screenshots I emailed you a while back?

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      I'll go back and check for the email. For the NMN, I'll need to read up on the literature. I am interested in it for diabetes, insulin sensitivity, glucose control, etc., but I haven't considered it for ME/CFS. - Jarred Younger

    • @gerardburns2500
      @gerardburns2500 8 วันที่ผ่านมา

      @youngerlab I've just taken some this morning, I'll let you know if it helps

    • @oliverbird6914
      @oliverbird6914 8 วันที่ผ่านมา

      @@youngerlab blood sugar regulation, In My opinion is implicitly linked to CFS. I think that dumysregulation from the sad diet starts early in phenotypically weak individuals. Lots of people with CFS have comorbities like diabetes or PCOS etc don't they

  • @lucidoneironaut4555
    @lucidoneironaut4555 11 วันที่ผ่านมา

    Are singing, chanting and humming also non invasive alternatives for vagus nerve stimulation?

    • @bryanevans1019
      @bryanevans1019 11 วันที่ผ่านมา

      Humming certainly helps me with my (probable)EBV-induced gastroparesis/motility symptoms.

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      Short answer is yes, they are. All of those can increase parasympathetic activity. But someone would have to do a properly designed and conducted clinical trial to get my attention. - Jarred Younger

    • @hookedonherbs3825
      @hookedonherbs3825 9 วันที่ผ่านมา

      @@lucidoneironaut4555 yes I do all of these they help a ton. The humming seems to improving immune or I am at least not getting every bug that gets anywhere near me.

    • @lucidoneironaut4555
      @lucidoneironaut4555 9 วันที่ผ่านมา

      @@youngerlab thanks yeah the only humming trials ive seen are about increasing nitric oxide to help with sinusitis. I think theres a phd at macquarie uni who has been studying the impact of chanting on wellbeing/moods but not specifically looking at pain.

  • @georgiachristenson5257
    @georgiachristenson5257 11 วันที่ผ่านมา

    Thanks Dr. Younger!

  • @kimberlyostertag9840
    @kimberlyostertag9840 11 วันที่ผ่านมา

    Could this account for those of us with " idiopathic" gastoparsis who have been diagnosed with " fibromyalgia"

    • @oliverbird6914
      @oliverbird6914 10 วันที่ผ่านมา

      I think MCAS is at least part of the picture there

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      VNS has been shown to help gastroparesis and fibromyalgia, but I'm not sure if taVNS (noninvasive) specifically has been tested in those conditions. But yes both conditions can involve abnormal autonomic balance that VNS can help. - Jarred Younger

    • @kimberlyostertag9840
      @kimberlyostertag9840 9 วันที่ผ่านมา

      I had the PYLOROPLASTY surgery done in Louisville. I now can eat pretty much what I want but I still have symptoms occasionally ( nausea, vomiting bloating) The biggest trouble is the slow transit constipation. I have tried various various nerve stimulation techniques and sleep in the cold . Not much here as far as therapeutics . I try to find things online. My friend who is an EN said that red light therapy is supposed to be beneficial but it's to expensive for me. Alast .. 🤷

    • @kimberlyostertag9840
      @kimberlyostertag9840 9 วันที่ผ่านมา

      @@youngerlab thank you for your teams and your hard work. Maybe one day soon . There will be a break through

  • @danatavares2038
    @danatavares2038 11 วันที่ผ่านมา

    I can see the positive electrode is placed on cymba concha of the left ear, but where would the negative electrode be placed? Ive see s similar study for migraine patients using 1hz very effectively.

    • @rhyothemisprinceps1617
      @rhyothemisprinceps1617 9 วันที่ผ่านมา

      An ear clip is used for the electrodes. There's a demonstration video that accompanies the article "Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS): Technique, Targeting, and Considerations" on the JoVE website.

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      I think the negative lead is also contained in the same ear unit. - Jarred Younger

  • @margaretlamont5267
    @margaretlamont5267 11 วันที่ผ่านมา

    Where is the reference to the paper on this please? (By the way have you ever thought of moving your position or the picture behind you so it doesn't look like a light bulb coming out of your head!)

    • @gretchendawson6768
      @gretchendawson6768 10 วันที่ผ่านมา

      That's his halo!

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      You can find the link in the description right below the video. The picture is signifying all the glowing good ideas, but I've been thinking of changing things up a bit. - Jarred Younger

  • @rhyothemisprinceps1617
    @rhyothemisprinceps1617 11 วันที่ผ่านมา

    I bought an Azelastine nasal spray based on research reports on its effects on respiratory infections; there seem to be some similarities with chlorpheniramine.

  • @rhyothemisprinceps1617
    @rhyothemisprinceps1617 11 วันที่ผ่านมา

    I played around a bit with TENS and microcurrent a few years ago with a unit that cost $50. The waveform was not adjustable (I think it was square). I had sciatica; I could directly block pain using the electrodes on the lower back; the device was battery powered and had a belt clip. I also tried auricular TENS for other health issues. In addition, I have a wrist TENS device for nausea called EmeTerm. When my daughter and I both became ill we both had nausea. She thought the EmeTerm helped a bit but she was unable to use it even at the lowest setting since it caused her skin to disintegrate. I was able to use it on max for long periods w/o this effect. At one point I remember doing auricular vagal nerve stimulation while also wearing the EmeTerm on my right wrist and getting so relaxed I started drooling. I should probably mention that I got rid of my sciatica problem by doing static stretching; it was gone within 2 weeks of daily stretching. Same thing for plantar fasciitis. The key was to hold the positions for 2 min. each. Stretching increases resolvin production.

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      Interesting one. I haven't seen the TENS/VNS combo, though I know some have tried using TENS devices as VNS. I definitely like that the stretching was so effective. - Jarred Younger

  • @PhillyGuy7575
    @PhillyGuy7575 11 วันที่ผ่านมา

    Very interesting, thank you Jarred.

  • @rowdytomato859
    @rowdytomato859 11 วันที่ผ่านมา

    Hi Dr. Younger, I'm curious to know if you have any updates on the zirconium-89 brain scans for ME/CFS? Thanks

    • @youngerlab
      @youngerlab 9 วันที่ผ่านมา

      Still working on it! No analyses to present yet. Just scheduling the participants now. - Jarred Younger

  • @illuminationgoddess3
    @illuminationgoddess3 11 วันที่ผ่านมา

    Thanks Jared.

  • @TonyNaggs
    @TonyNaggs 11 วันที่ผ่านมา

    Tantalising. It would be interesting to see a study of later generation ("non-drowsy") antihistamines.

  • @Mark-gp4yn
    @Mark-gp4yn 12 วันที่ผ่านมา

    Things have not changed. Stop kidding people, there will never be a cure for this illness.Just be honest with us.

  • @inspectorraycharles
    @inspectorraycharles 12 วันที่ผ่านมา

    600 is expensive indeed but, if it works and you can replace other medications that will offset the costs. My monthly deductibles are about 200. I take Adderall, Lyrica, and buprenorphine all scheduled drugs with lots of side effects. If it really works and I was able to replace those drugs, I'd be ok with it, especially if it allowed me to work again.

  • @isatousarr7044
    @isatousarr7044 13 วันที่ผ่านมา

    Recent research has provided new insights into Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), particularly concerning its association with SARS-CoV-2 infections. A study funded by the National Institutes of Health (NIH) found that new cases of ME/CFS increased 15-fold following SARS-CoV-2 infections. This underscores the potential for viral infections to trigger ME/CFS, highlighting the need for ongoing research into its causes and potential treatments. Additionally, a comprehensive NIH study identified brain, immune, and metabolic abnormalities in individuals with post-infectious ME/CFS. Notably, the study observed distinct differences between men and women with the disease, suggesting that gender may influence the disease's manifestation. These findings are part of a broader effort to understand ME/CFS, which is characterized by severe fatigue, post-exertional malaise, and other debilitating symptoms. Research is ongoing to uncover the underlying mechanisms of the disease and to develop effective treatments.

  • @isatousarr7044
    @isatousarr7044 13 วันที่ผ่านมา

    There is some emerging interest in the potential use of oxaloacetate in managing fatigue in conditions like Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), though the evidence is limited and further research is needed to draw definitive conclusions. Oxaloacetate is a metabolic intermediate in the citric acid cycle (also known as the Krebs cycle), which plays a crucial role in energy production within cells. Some studies suggest that oxaloacetate supplementation could potentially support mitochondrial function and energy production, which may be beneficial for conditions involving chronic fatigue. In theory, since ME/CFS is associated with mitochondrial dysfunction and impaired energy metabolism, the supplementation of compounds like oxaloacetate could help improve cellular energy production and, by extension, reduce fatigue. Some research in animal models and small clinical trials has suggested that oxaloacetate could improve energy levels and reduce oxidative stress, both of which may be beneficial for people with ME/CFS. However, it is important to note that the research on oxaloacetate's effects specifically on ME/CFS is still in its early stages, and results are mixed. Clinical studies involving larger patient populations and rigorous controls are needed to determine its effectiveness and safety as a treatment for ME/CFS fatigue. As of now, oxaloacetate is not widely recommended as a treatment for ME/CFS, and people with the condition should consult with their healthcare providers before considering any new supplementation. In conclusion, while there is some preliminary evidence that oxaloacetate may have potential benefits in reducing fatigue related to metabolic disorders, more comprehensive research is necessary to establish its role in managing ME/CFS.

  • @minahana1112
    @minahana1112 14 วันที่ผ่านมา

    What other common causes are there for anxiety then?

  • @minahana1112
    @minahana1112 14 วันที่ผ่านมา

    Allergic reactions usually trigger anxiety.

  • @ganeshadhi1488
    @ganeshadhi1488 14 วันที่ผ่านมา

    "Magic mushrooms, with their psilocybin content, could have potential benefits for CFS."Could you check the potential of magic mushrooms (psilocybin) in helping with CFS?

  • @dawnmorning
    @dawnmorning 14 วันที่ผ่านมา

    Would FND or MCAS show similarly increased CPR levels.