วีดีโอ

Will these test detect past inflammation that your not feeling now?

Don't forget that many of us GWI sufferers also suffer from a huge amount of allergies. French Pine Bark? Would just be another allergan causing inflammation...

I have never had the test. I am taking supplements ( Thiamega & also a seperate Benfotiamin). Since starting the later, I seriously cut back on carbs. Physically, I feel much better. Worth trying.

I've tried 4.5 LDN and last week was started on .05 LDN and I could NOT tolerate either: Had increased anxiety, increased insomnia, headache, severe agitation and random tearing up or crying for no reason what so ever! I've been diagnosed with CFS/ME/Fibromyalgia/Tickborn disease including lyme, (Insert many more chronic health symptoms) Primary Immunodeficiency -CVID and treat with weekly infusions of SQ IgG Hizentra since 2012! I was really really hoping I could tolerate this as pain has had me bedridden on and off over the last 2 decades.

I would pray that someday soon there is a very concise video or article I can give my doctors. Your updates are interesting but no doctor will watch these rambling reports. Where is the summary? ME has a stigma in part because to this day there is nothing my doctor can find on how to confirm it. Beyond frustrating..

The only thing that has helped in my case is taking high doses of Benfotiamine (Vitamin B1). I needed to get above 500mcg with 2x B100 Complex, 6000mcg of B12, 800mg of Magnesium bisglycinate, 6000-10000iu Vitamin D, 720-1200mcg Vitamin K2, 3600mg Omega 3. There may be a need for some Zinc as my skin sometimes gets rashes on my feet. My gut feeling is there is a chronic deficiency in thiamine in so many people, and it definitely makes sense for soldiers as they have chronic stress.

I have a ton of pain in my shoulders and hip, but my CRP comes back with no indication of chronic inflammation. For years I was a garbage man and was first diagnosed with arthritis in my knee at 27. About 7 years ago I was diagnosed with 50% cartilage loss in my hip (osteoarthritis), and my shoulders have been difficult to sleep on and raise with any kind of weight for years. If my CRP is low, I'm curious what else might be going on. Maybe calcium deposited in my joints from Vitamin D3 from years ago, before I realized K2 was needed when supplementing? Pain sucks.

Fasting works brilliantly, better than any meds available. Once you reduce the amount of fat the pain and fatigue, brain fog etc just melt away. I lost 5.5 stones, believe me it works.

Isn’t CRP also a proxy marker for fasting insulin?

No, updates so far?

CFS/ME My CRP 735 U/L. (Australia BT) Have any of your patients tested positive for myositis antibodies SAE1. I did but didn’t have any of the standard symptoms regarding SAE1. Just thought I’d mention as your team seems like you actually are trying to find a solution 💪🙏

I’m looking back now in my records. Quest (for CRP) says an acceptable value is <8mg/L. Quest (for high CRP) says acceptable is less than 1mg/L. Labcorp (for CRP quant) says acceptable is below 10mg/L. My drs office lab (for HS CSP) specifies acceptable numbers are less than 1.0mg/L. If I convert my numbers to deciliters, then I’m doing even better! I have no inflammation but MECFS anyway. Perhaps this is an important test for grouping MECFS into subsets- those who have high CRP and those who do not.

Wonder how many of these patients have undiagnosed autoinflammatory diseases especially if they have co-morbid rashes, urticaria, joint pain fevers, mouth ulcers, GI problems, eye issues, etc 🤔

What is your opinion on GLP-1 drugs for pain and inflammation? www.thelancet.com/cms/10.1016/j.eclinm.2022.101737/asset/ef6ea3a1-e55c-4fa0-b2fc-ca3c8e6bdbc1/main.assets/gr1_lrg.jpg

Everyone I know with severe and very severe ME/CFS has low CRP! I hope this will be reflected in the data. Pro inflammatory cytokines are alolso mostly low and decreased whereas antiinflammatory and immune suppressive cytokines are usually very high. Modulation of these cytokines with things like BCG vaccine (which leads to Th1 and pro inflammatory switch) helps many severe pwME/CFS

my crp is 25. It's been that for months!

Vitamin B1 deficiency has multiple symptoms. Mine were severe muscle pain in my hips, buttocks and thighs, anxiety, and swelling in my legs. After 2 weeks of taking benfotiamine (synthetic, fat-soluble B1) 300 mg twice a day (with magnesium with one dose), my anxiety was completely gone, leg swelling was 90% better, and pain was greatly improved. I was still taking Tylenol, ibuprofen and a natural anti-inflammatory supplement with tumeric, stinging nettle, etc. but the pain meds worked so much better and took less of them. There were times when I was pain free, which hadn't happened in the previous year and a half.

I had moderate to severe muscle pain in my hip, buttock, and thigh muscles following a bulging disc. The lumbar back pain went away after 5 months but the muscle pain remained. I went to the doctor, recommended physical therapy with little results. I tried curcumin, stinging nettle, and various natural combinations of anti-inflammatories with no help. None of these worked until I got my vitamin B1 levels up. I started benfotiamine (a synthetic, fat-soluble form of B1) which enter the cells easier than thiamine. 300mg in the morning and 300 mg at night. I also take magnesium with one dose because Mg is a cofactor for B1. I'm 58 years old and a nurse working on a neuro/trauma floor, so I was limping around for a year and a half, pain peaking up to 8 out of 10, every 6 hours 2 Tylenol and 2 ibuprofen with some relief. 2 weeks after I started the benfotiamine, I again tried taking pain supplement with tumeric that my husband takes for arthritis and it worked. My muscle pain has been reduced by 75%. I can see why people get depressed with chronic pain. I'm only on my third week with some hope. The B1 also reduced the swelling in my legs and improved my mood.

Wow, excellent.

Thank you and as usual, no apologies needed. Your work is much appreciated. Also, I watched one of your older presentations recently and was left wondering How _did_ that tree get into the building 😅

See dr Sabine HAZAM cal, lots research on gut/stool stuides, mocrobiome, used her own cllleagued + self as subjzcts, did ore covud damples then post covid, covid pt had NO good microbiota in stool /none, am dealing w this now from covid..she was ignored 4 years, now published..book : lets talk shit very elemental, tu for info❤️

At the time of diagnosis I had two doctors that worked my diagnosis. As I hit mid 50s I was overall physically very active and healthy with occasional bouts of short term typical intense symptoms which the worst was cycling gastroenteritis without any diagnostic links. At the time I was driving a lot doing agricultural equipment inventory sometimes 500+ miles a day. Eventually, it became so bad I would have acute diarrhea sudden onset. At times I was forced to stop beside the road. My GI doctor eventually sent me to a GI "yoda" world renowned in Houston. He ran some exotic diagnostics, all normal parameters in all tests. I think he thought I had a psychological problem. I completely understand how he'd think that. And, without a diagnosis and not having a treatment I was frustrated and depressed to the point my psychiatrist was concerned enough to prescribe an antidepressant Mirtazapine. Within a few days I felt much better and my GI problems practically stopped completely. When I advised my GP this, that was the clue that brought my fibromyaliga diagnosis. That was 20 years ago at least. I'm still on Mirtazapine and my disease has steadily increased forcing my retirement about 5 years ago. Now I take 5meds that give me a few functional hours a day with poor sleep. I know there are lots of people like me. I'm going to ask my GP about Creactive test. Thank you for highlighting the subject!

I’ve never had a cRp under 1 and it’s so frustrating. I’ve been fully organic plant based for three years now. I went fully plant based after finding out I’m part of the 20% of the population that has high Lp(a), but mine is like, really high. 380 nmol/L. Before I was consuming raw milk, butter, grass fed beef, and lots of organic plants. That diet led to me having REALLY high LDL, LDL particle count, and particle sizes. I’ve gotten my LDL down to 108 now with a plant based diet but I still can’t get my cRp to go down. Could my really high Lp(a) be a factor? I’ve always been small, BMI is 19.6, A1C is 4.9- like, what else could be the reason my cRp is high?! Ps- I did an Ana Screen and it came back negative. I don’t have any autoimmune diseases and I’m never sick.

Thank you for providing proof for what some others deny exist.

The pet tracer used with leukocytes, how dangerous is it? Where does it fall on the elemental chart?

A 90 day trial of LDN did nothing for my CFS.

I always check crp with esr with ferritin to get a more generalised figure….plus e/lfts and occasionally d-dimer.

for two years of lc now i been havin consistantly plus minus 20. am obese but before lc it was zero-ish. i am improving, working on integrating ctraumas and i am sure it will at the given moment be fine again.

How significant/prevalent are anti-CRP antibodies?

Do you think that CRP would show differences with our low-dose nicotine patch research? Is hs-CRP standard in some places or does it have to be special request?

Whenever i have flares of my chronic inflammation, my CRP is high, but my Antinuclear Antibody test is always negative. This is the reason it took so long to be diagnosed with autoimmunity. Is it possible that it has something to do with the difference between auto-immune and auto inflammatory?

I've been thinking about this more lately, and I appreciate you helping me to understand something as fundamental as this. Godspeed!

Hi Dr Younger, Would TRPM3 dysfunction effect CRP levels? I'm also just curious what your thoughts on this research is? They've found TRPM3 receptors in the brain so that could maybe explain the activated microglia not recieving the turn off messages. Just trying to bring 2 ME/CFS theories together to see which is more likely caused by the other. Here's one of the most recent articles on TRPM3 if it's if interest: www.ncbi.nlm.nih.gov/pmc/articles/PMC11227206/

Thanks for the video. My CRP has always been normal, even though I have a couple of different types of arthritis, degenerative discs and scoliosis, fibro, a few other pain issues, and me/cfs. Is this because of the type,of CRP tests I’ve gotten from my GPs? Could supplements or meds interfere with CRP test results. My me/cfs doc and pain clinic never tested me for CRP, afaik. 🤔

Mine CRP doesn't show up and too many pwME same.... Instead hsCRP, immune complement factors, histamine, IL-8, IL-6 and MMPs go high. I don't get this video, I am sorry. It's chronic inflammation and CRP is acute infection.

I have a question - my CRP levels have always consistently been < 0.3 every time I've been tested, including when I've been doing particularly badly. These were not high-sensitivity tests - so I'm wondering, considering the above fact, if they *were* high-sensitivity, would the variation that could have been observed within that 0-0.3 range be a useful marker/even if CRP is just below 0.3, would there still be much benefit in reducing it further? Or is >= 0.3 just 'healthy' and if we're in that range, we needn't worry about CRP (much) further?

When I had pelvic inflammatory disease 18 years ago. It was at 50 for a year until the bacterial infection in the fallopian tubes cleared up. It was a very difficult time of my life. The doctors never told me what a CRP of 50 meant. It was a scary period. I hope noone can relate nor needs this information. Just putting it out there.

THANK YOU! ❤ I’m so glad that you’re looking into this. I’ve noticed that I have a LOT of pain when my inflammation (CRP) is high but I haven’t noticed a change in fatigue. I have seen my CRP go down within a couple days after an infection starts to resolve. I think it would be great to have an at home CRP device. I have glucose and Uric Acid test kits.

My CRP has tracked with my platelet count since 2021 - the start of my chronic inflammation and fatigue. Finally gone down now due to lifestyle changes I made last year - hopefully it will be optimal soon. Fatigue has more or less gone.

Your videos are so clear and easy for us non-doctors to understand. Thank you!

Boy i would donate to a kickstarter for a near real time inflammation tracker sooo fast!

Yep... My old doc (RIP) used to track my progress using CRP. Always not quite where it should be lowest i recall was 3.5 , usually 5/6, sometimes 10/11 Looking forward to next week Dr Younger ,vand thank you for your continued work 💙🙏🏼💙

Maybe they have the mthfr gene! Maybe that would explain the high CRP.

Great sensitivity? The number of subjects with symptoms and low CRP seems to prevent us from trusting a negative result (<3mg/dL). What about all the gulf war illness cohort with normal-range CRP? Should the protocol include frequent periodic samples for each patient?

A home CRP kit would be handy, has anyone invented it yet?

@youngerlab I see the plant flavonoid Luteolin turned out to be a good anti inflammatory in the inflammation stage of acute Covid. It’s a big paper so I didn't read if it helps with Long Covid or not, but probably would help Study name: ‘Inhibitory Effect of Luteolin on Spike S1 Glycoprotein-Induced Inflammation in THP-1 Cells via the ER Stress-Inducing Calcium/CHOP/MAPK Pathway’

What’s the timescale the test covers? In other words, do I need to be in a crash to see the higher levels of CRP? Or will it show inflammation over the past couple of days or weeks?

My CRP has been constantly 2.0 mg/L since 2014 following a tick bite which made me very ill and it hit 64mg/L (6.4 mg/dL) at the time, I was ill ever since but did feel well most of the time, and got back to some level of normality. Theme came Covid vaccines, I took a Moderna in Nov 2021, and was really ill afterwards got tested a week later it went to 33.4 mg/L then settled back at 2.0 ever since, I have bought of really bad fatigue and constant burning pains in legs and arms, aching joints spikes pains in random places and apparently my low CRP means there is no inflammation. This is so strange as it feels like inflammation and does seem to ease when I take a fexafenadine. Everything I have read seems to point to this, especially the joint pains I get. But because CRP is low I get sent away. Is it possible to have a low CRP but still have inflammation?

I'm 72 years old and I've been fibromyaliga diagnosed for at least 25 years. I've had a lot of blood tests over the years including many CRP tests and I don't believe I've ever had any values that were abnormal. One if the ways my doctor diagnosed my fibromyaliga was my CRP values were normal even when I was having acute fibromyaliga symptoms with pain and fatigue but my CRP values are usually normal.

Thanks for this. Is consistently high CRP causative of cardio-vascular damage or is it a symptom?