As I mention in the talk, do not try any treatments because they are on this list. Many of these compounds do not have even basic safety testing in humans, and some of them have never even been tried by a human. This list is solely to show the types of things I am considering for further investigation. Thanks! - Jarred Younger
May I suggest pentoxifylline? If hypoxia is the cause of microglia malfunction, rather than the result, pentoxifylline makes RBCs more flexible, so they can carry oxygen through constricted arterioles and reach capillaries that might be otherwise blocked. Brand name: Trental. I do not know whether it crosses the blood-brain barrier, but it has been successfully used for decades to improve oxygenation in lower extremities with peripheral arterial disease.
@@AniBAretz pretty sure ozone therapy does the same thing with RBC flexibility and also greatly increases the delta between RBC oxygen saturation and oxygen depletion i.e. increases the amount of usable oxygen in the blood. (Ozone therapy increases a-vO2)
@@AniBAretzI am currently 5 weeks into an 8-week course of Pentoxifylline (400mg 3x daily) as an experiment (under medical supervision) for ME/CFS. I would describe myself currently as physically severe (98% bed bound according to FUNCAP55) and cognitively moderate (thanks to LDN). On paper, Pentoxifylline made a lot of sense and my doctor was willing to prescribe it, but results have been disappointing thus far, it hasn't moved the needle in any of the ways I was hoping for. Obviously this is anecdotal, N=1 etc ..
Please never stop posting videos. You’re doing a huge service to all of us struggling with CFS/Fibromyalgia that we’re all thankful for. It’s good to see new research being done in this area and making your findings public for all of us to learn from.
I suffer from severe me/cfs in the aftermath of a covid infection. I just wanted to say thank you. You are one of my heroes for working on this and being so transparent with us patients.
That’s impossible because there many different subsets/root causes, dozens if not hundreds. You’ve been lied to by Reddit and forums saying there’s one ME/CSF and it’s the only thing that can cause PEM.
Thanks for sharing! You are setting a great example. Sad to see that low-dose transdermal nicotine is not on your list since it seems to tic all the boxes. Your push for open-decentralized research methods is fantastic! Keep it up!
you're a great beacon of hope, and so compassionate and understanding of the experience of the one suffering from these conditions. to see a list like this is so soothing, you have no idea!
I was given Amantadine for a different condition and it made a major change in my neuropathy and fibromyalgia symptoms, especially pain, strength, and fatigue levels. I did find out the hard way that the brand of the generic makes a huge difference (Upsher-Smith has been the best out of Strides and Activis, which was the worst performer). My best friend who has very similar diagnoses as me had the same experience. It definitely seems to be affecting Neuro inflammation but I don’t see many studies on it outside of MS and Parkinson’s. This experience has also made me wonder how many times people tried a medicine that would have worked for them but because of the differences in how generics are made they abandoned the medication instead of tried different brands. This is the fourth medicine I’ve had this issue with.
I have this issue with migraine meds. There have been problems with generics labs, so i'm (dismayed but) not surprised at your experience. Interested and glad to read amantidine was helpful for you!
Amantadine has some interesting actions on microglia. I am adding that one to the list. Thanks! I made a note about the generic brands. Generics can use different processes to get to the final compound, but they are supposed to be exactly the same - for sure with U.S.-based manufacturers. We do purity testing on the medications we use to make sure is what we expect. If amantadine made it to the top of the list, I would probably get some from different suppliers to test. - Jarred Younger
Thank you for this. My me/cfs Dr has me trialling rampamycin as he thinks it has potential. Early days so nothing to report except that it hasn't made me worse which is always a relief
Thank you for taking time to list these and to warn against experimenting with them. I'm on LDN. Didn't help fatigue or cognitive issues, but does help me get quality REM sleep. Which is a win in itself.
Jarred, this is great! Seeing the 3 slides of potential treatments on the horizon, I'm feeling more hopeful than ever. What matters to patients like me is whether effective treatments are on the horizon, and how soon they may become available, and you obviously understand the dire need for treatments. Thank you!
I am intently curious how our near infra red-starved lifestyles, largely devoid of regular exposures to daylight (particularly the NIR), plus the similar experimental laboratory NIR-starved environments, might need to overlay the quantum biology of light issues into this assessment? Low D3, low NIR inducement of mitochondrial exposure benefits for structured water energy function and melatonin production, may be essential to understand along with these important inflammation understandings? Our switch to too much indoor LED lighting (cutting out the NIR from incandescent lighting), appears maximally problematic for increasing inflammatory effects as well? No? More scientific understanding of quantum biology of light quality seems essential in approaching such research list potential benefits for humanity. Daylight exposure, carefully done, is essential for consideration given this 'dire need' for emerging treatments IMHO
Oh, I hope you will include CRPS! I have been dealing with this nasty condition for 20+ years! I, also have myasthenia gravis (and salicylate allergies) which makes it a challenge for participating in trials... but it may be interesting to see if they are interconnected. The differential diagnosis between CRPS and ME/CFS and/or Fibromyalgia and CRPS would be great to know if the treatments you find to address glial cells and their involvement in the experience of pain and physical limitations.
I sure hope you get the funding for a Centre. That would be a game changer. But I hope there are avenues other than the NIH seeing how they neglect and spite these conditions still.
It seems likely there is DRG involvement in ME/CFS, and very likely in fibromyalgia. It is tricky to do studies with DRG in living humans. I am trying to get whole spine in my PET studies so we can get at least an idea of the spinal cord involvement. I would suspect DRG involvement when the initial instigating event occurred in the periphery rather than the brain, and when abnormal pain sensitivity is involved. - Jarred Younger
Methylene Blue works incredibly well for my ME/Long-COVID/MCAS brain inflammation. 10mg allows me to play video games for a few hours (impossible without it) and when I combine it with 0.5mg Ketotifen it allows me to safely eat things that would otherwise cause instant anaphylaxis. It also fully counteracts the drowsiness from Ketotifen. Seriously underrated compound. 🔵
@@Dalf-x5m Science(dot)bio nootropics. Using Shipito to forward it to Netherlands. Whatever source you pick, always check the purity testing reports by 3rd party labs. Never trust uncertified compounds.
There's a large subset of we with me/CFS that have toxin overload and genetic errors in the ability to methylate and detoxify and have gotten worse after taking medications. If a promising medication is found many will rush to try it and I fear the outcome. I hope the possible drug can be used short term or work so well that it supercedes the need to protect ourselves from chemicals and toxins.
Not sure this is relevant, or not, but the use of photon light treatments versus medications needs to be explored and made more available, especially through insurances.
@@eddie8489 Thank you for the feedback. I have a problem with being in direct sunlight for more than just a few short minutes. I can handle the shade, but direct light can cause weaknesses that are debilitating... I do take D3 and K2, however.
@@mercy3219 same exact thing with me!! Even a few minutes puts me down for an hour with weakness, inability to think or speak, fatigue. I’m actually post sunlight now so I’m about to go through hell. I really think it has to do with excessive vasodilatory response.
@@eddie8489 I have myasthenia gravis which has a known connection to sunlight sensitivity. You might consider seeing a neurologist -- it can become quite a serious situation if you have it (or Lupus, or other undiagnosed issues). Take care, please.
Keep in mind, a variety of other conditions that have overlapping features with ME-CFS (and this rogue gallery) involve negative responses to sunlight: Porphyrias, Dermatomyositis, Lupus, etc. Not saying either of you have these conditions but the other mechanisms should be contemplated when troubleshooting for this spectrum of disease [pun intended]. Last tidbit, I think aside from a negative immune response (adaptive or innate) as a possibility, there is also an interesting energy requirement and chain of events when receiving sunlight. I first consider the precursor for Vit D production: 7-dehydrocholesterol. These energy/metabolic cycles are always reasonably in the discussion with ME-CFS. EDIT: I just saw your comment about having MG. I have a similar crossover with MG, Sjogren’s, Lupus and more. Almost like MCTD. It is brutal (100% bedbound in my 30s; came on suddenly at the end of 2020, likely after Covid or similar infection).
I have severe long covid for 4,5 years and was a little recovering every year. But few months ago I had a tick bite (neurological sadly) but I’m now on Minocycline and it’s helping my long covid! It’s difficult bc I now have also Lyme symptoms and a lot of adrenaline. But certainly my long covid lifted a bit but I don’t know how it’s on the long run. I had this also with doxycycline and a little with naproxen. Less tired and less PEM, more clear in my head. I think it lifted inflammation in my brain. But coming off the doxycycline was difficult back then.
I had 4 ops on my teeth all under general anaesthetic but after one of those ops I came home and felt no ME/CFS symptoms my head was clear, I had energy and my posture was upright even my parents said “what’s going on with you you look like your old self” woke up next day and was back to ME/CFS. So out of those 4 ops there has got to be one different drug that was used that made me “normal” I can send you all 4 anaesthetic report as I cannot understand it. Thank
Interesting, I had GA for wisdom teeth and it was the best sleep I ever had, I felt lovely and refreshed. EDS patients have a different response to anaesthesia and opioids.
Dr Younger, love your work! Just wondering if you have any views on neuromodulation for ME/CFS and long covid? And in particular the use of vagal nerve stimulation? There seems to be dome theoretical basis for this, given issues of neuroinflammation, brain connectivity etc in the illnesses. Thanks
Thank you for this 'open' approach! IMHO, searching across specialties and broadening 'peer review' exposure seems prerequisite for best scientific method toward more fruitful outcomes. I have recently come to understand need for approaches considering quantum biology knowledge as a bedrock to inform QA/QC for such important effort. Lab subjects are all evolved by having adapted over untold thousands of years to thrive outdoors. The complexities involved in their physiologies, we are only 'scratching the surface of'. The energy carried in the orchestra of daylight breadth of wavelengths sustains physiology complexity. Lab environments, lit by LEDs and fluorescent light, w/o benevolent modulation of 'what was left outdoors' really DOES need to be accounted for. Lab animal physiology (especially human), is essentially and thoroughly tied to the physics effects of the specific light reaching it. Shinning toxic isolated narrow bands of wavelengths biases the resultant outcomes of testing. Best wishes for your work, onward and upward into the light.
On the list under hormones, I would highlight 'mitochondrial melatonin' as well as pineal melatonin. Also, Vitamin D3 hormone plus its other active forms produced in daylight. Dr, casey Peveler on YT has summaries of research on these as presentation videos.
Bacillus subtilis helped someone I know very much (1 teaspoon of powder 2x day on empty stomach, but sometimes more). They used Vitamatic brand from Amazon in the USA.
Jarred, thanks for all your work and research. Can I ask a question? Are there ME/CFS researchers like you in the UK who do clinical trials similar to what you do? I'd love to apply to be in a trial if it's available anywhere near to where I live.
It is a dynamic list - I'm adding to it all the time! I can go to a page 4. :-) I've seen the peripheral immune effects for a few years now, but the evidence of microglia effects is just now coming out. It should pass the BBB, so it is an interesting compound I will look at further. - Jarred Younger
That's interesting. While I'm not familiar with how clinical trials are typically designed, it seems a bit outdated to apply the same treatment to everyone with a chronic disease, especially when the condition can manifest differently in each person. With today's technologies, such as knowledge graphs and machine learning, we have more advanced options that could lead to more personalized treatments, potentially combining botanical solutions with drugs. These approaches could also improve safety outcomes and save time.
Thank you for this list. Good to see such a wide variety of dugs & supplements on it 😊 Have tried quite a few of them over the years. LDN helped my ME-driven insomnia for a while, then gradually stopped working, so I abandoned it bc it's too expensive. Dextromethorphan is great; takes the edge off of the worst payback/PEM. Still have to rest & pace though!
@youngerlab Would you consider inversion as a potential home-remedy/therapy for increasing oxygen to the head/brain if done responsibly? For example: laying down on an inversion table for two minutes, twice a day?
I'm still trying to get a synthetic chemist to make dextro-naltrexone, a compound I hope will hold its effects in people where normal LDN does not. But it will be a while before it is available for testing. I hope you are able to find other things to help! - Jarred Younger
@@youngerlab Will there be a way to stay abreast of future trials that might use this drug? Do you imagine it would be only be ME/CFS diagnosed patients? Jumping the gun here but would love to be part of this since LDN worked so well for me for a time.
I was put on candarsatan for my hypertension but had urinary issues. Hard to empty the bladder. So I was put back on losartan. But my GP messed up the convertion and put me on a too small dose than what my cardiologist prescribed. So I was on the same dose as before I got to the cardiologist. My systolic BP hovered around 135 and my GP thought that was fine and told me to take walks but I couldn't. I then switch GP and realized the mistake my former GP had done. So my new one doubled the dose. Then I got very sick and she let me have another 24h measurement and increased the dose even further. As long as I'm under 120/80 I felt pretty good and could take pretty long walks all of a sudden. But I get really dizzy if the systolic BP reaches like 130/90. On this medication I get like equally dizzy at 130/90 as if I was on no medication had 145/105. It seems losartan and a blood pressure at under 120/80 make me way less fatigued. Sometimes I believe my ME mainly came from the fact no one treated my hypertension to begin with. They just assumed my BP was elavated because I was in a medical setting when it was tested or something. But I need to mention I also started having B12 injections, folinic acid and iron in combination when increasing the dosage. But with B12 or not I'm really sensitive to blood pressure changes. If I'm concentrating really hard on something like nailing a hard guitar solo or stuff like that, the sudden spike in blood pressure can make me really dizzy and fatigued still. So it must be tied to like hyper focus, and maybe stress hormones. I wonder if like alpha blockers would combat that?
I'm using MB currently and it's s done wonders. I do like LDN better, but I'm not able to take it currently . The issue I have is MB is detoxing parasites faster than my body is currently able to handle, so I've had to slow down on it. I was also wondering if he'd bring this up in his research
@@tammyrobinson1613 I didn't realize it was an anti-parasitic. I tried LDN once at the lowest dose but reacted badly to it so am not willing to try it again. Thank you for the heads up re: MB.
Thank you for sharing and being diligent. I really can't say how good black seed oil can be . Thymoquinone is a very strong part of black seed . It stopped my pots and adrenic response for months
Exactly this. I think gut dysbiosis + intestinal permeability causing immune system deficits is likely a major root cause. FMT addresses this root cause so I was very disappointed to not see FMT listed. I emailed him about it recently as well.
You don't need to worry about me testing any of them, because starting to improve after nearly 3 decades and none of which I'm taking (just the mainstream minerals and vitamins but the gist is in balancing the amounts and forms) are on there 🙃 If you take just one or a few things then I'm sure your list is helpful!
LDN, along with relaxing my nervous system; addressing very low thyroid using NDT, and doing trauma work has helped a lot. There's still a missing piece to get me more than 70%
Seeing 2 antibiotics on the list may confirm an experience I had a year ago. Back story: We live in an area with a lot of feral cats. In the process of transferring a feral cat for neutering, I got a nasty scratch, which led to sepsis. I have had 1 round of antibiotics in my adult life (tick bite) 30 years ago. The sepsis from the cat scratch led to a necessary penicillin injection and rounds of 2 different orally dosed antibiotics; which lasted for 2 weeks. I don't do well with anything injected, so I spent 3 days in bed with a flu-like reaction. But after that, I noticed that I had no pain. None. Not in my joints, not in my muscles. I asked the Functional Medicine Dr. I was seeing at the time. He had no theories or explanations to offer.
These types if events are fascinating. Frustrating you couldn't get some to dig deeper. I'm not sure if you're associated with them, but your experience sounds similar to what the Remission Biome project folks experienced- just mentioning in case you haven't connected with them.
Dextromethorpan has nearly eradicated all of my cognitive PEM. I still have brain fog but I’ve been able to read, be on my computer all day, chat with friends, and watch movies without the intense pressure/cotton headed feeling. I first noticed it from taking Robitussin.
Thank you so much for your work. I discussed taking DXM with my me/CFS literate doctor who is on board. We discussed the potential mechanisms and discovered that it inhibited microglial activation. He mentioned that ketamine might also work similarly but I haven’t heard much else about that.
It helps me a lot (physically rather than cognitively) but not to the extent that I can increase my activity level or stop pacing. It just reduces some of the fallout.
I have tried Rapamycin 5mgs once a week for 8 weeks. For the first 4 weeks I thought I had finally found a drug to control M.E ,then it all went down hill and the M.E symptoms came back just as bad. So I stopped.
Sensory nerve damage is important too from virus hence ME and to have such a terrible reaction to sound is extremely difficult to bear. No doctor has ever tried to help my case. “ neuralgia” of the brain and ears from the other side of the tympanic membrane and uninflected but some sort of disorder that interrupts thoughts too. Ugh! No flying or scuba diving didn’t cut it.
I would really like Methylene Blue and Low Dose Naltrexone studies to be more conducted. LDN is kind of a double edged sword, as it usually works for cca. 50% of the patients. What is your opinion on TUDCA, CBD (or even THC), NADH and L-Carnitine?
Both of those you mention specifically are in my top 10 to investigate. I've also submitted grants for CBD and looked into THC. The other chemicals I haven't looked into closely because I always considered them more critical for basic cellular processes rather than microglia modulation. But I have another list of interesting compounds that don't involve microglia modulation specifically. - Jarred Younger
@@youngerlab Thanks, Jarred! Besides CBD and THC, have you studied CBDV (Cannabidivarin)? That cannabinoid molecule also has anti-inflammatory and even neuroprotective properties?
What is the connection, if any, between neuroinflammation and mitochondrial dysfunction which is purported to be a key driver of MECFS? Thanks for your work!
Mito dysfunction and inflammation are a vicious circle with ROS in the middle. The proximate cause could be CSF flow issues, gut dysbiosis, or many other things.
Hello. Any chance you can look into peptide ss-31 and give your 2 cents regarding it might being something very useful once more research is done. It looks great on paper. Thanks so much
If someone is supposed to start rosuvastatin anyway for high ldl, for your opinion, is the potential in low doses as well? the potential is for standalone or as part of polypharmacology?
Are you trying to put him out of a job? Anyway, I think you'd still need someone to coordinate and actually run the testing, that is until we have humanoid robots who can do all this?!!!
@@mattpotter8725 as Dr. Younger said in the video, it would take several lifetimes to properly trial everything on his list, AI could help narrow down what the most promising candidates might be.
I tried ChatGPT only once. I wanted to turn one of my scientific publications into Stephen King style. It didn't work. :-/ I like the idea of AI interpreting and organizing the published data in unique ways. I could contract that task out and see what they came up with. I haven't been keeping up with the academic/scientific versions of AI. I just know the advances are occurring at a dizzying pace. - Jarred Younger
It’s such a shame to see such effort be applied in an insufficient manner. There have been case studies of people who have been cured. There are specific doctors who have had REALLY good success. It’s like you’re starting at square one in trying to build “aHiroshima” meanwhile other countries already built it or have done the work, and are the majority there. Once I’m done fully curing my case, I’ll have to put everything I’ve found together in a presentation or something
Not saying your work isn’t worth it nor good. I believe what you’re working with will and can help in A LOT of ways. Would it it help map out damage/repair pathways? Yes. Could that help eventually lead towards valuable and useful information? Yes. Could it help symptom patching for people with little to no hope; most certainly. But it doesn’t find/address the actual cause. Had to add this reply because I wasn’t trying to say your work is for nothing.
Curious what country has done the work and have a majority recovering? Or a majority of any answers on causation or treatment. Researchers around the globe are collaborating on 'square one' trials & studies. If there is valid, peer reviewed scientific data from any country I have yet to find it & would be most grateful
All you need is oxaloacetate. All inflammation markers down. Even experienced nerve regeneration from damage 24 years ago from Bells Palsy. No long term use required. It HEALS.
With all due respect and genuine gratitude for your work, I must say that I find it extremely disappointing that you've chosen not to go more in-depth in the substances that you are highly considerate of being an effective treatment - Given the lack of resources, that are at our disposal, to even imagine testing all of these various compounds is unfortunately out of scope, hence why it's very reasonable to prioritize the most promising ones, that goes without saying, though especially with the limiting research that has been conducted, getting the word around, the ones that show great signs of effectiveness, might cause the wonder people are desperately waiting for.
Changing my diet saved me from debilitating back pain, nerve pain, joint pain, muscle pain, digestive issues, raised blood pressure, 20kg over weight. It took around 8 months for all these problems to resolve. I'm completely pain free and never felt and looked healthier. Since 2020 I've only been eating fatty meats, seafood, eggs and dairy. Prior to that I was eating the mainstream version of a healthy diet (lots of veggies, fruit, whole grains, low fat, eating the rainbow etc) for decades and watching my health slowly decline. Dr Anthony Chaffee, Dr Paul Mason, Dr Ken Berry, Dr Shawn Baker, Dr Gary Fettke, Dr Benjamin Bikman, Dr. Malcolm Kendrick, all helped me get my health back.
Why isn't FMT listed? None of these seem likely to cure CFS. They might be able to treat some of the symptoms. None of them address the root cause of CFS, which is likely gut dysbiosis + intestinal permeability causing immune system disfunction. FMT addresses that root cause.
@@PhillyGuy7575 FMT is highly donor-dependent. High-quality donors are extremely rare. I've screened 1.2m+ people to find good donors, but I need help from the medical and research communities.
There can be other root causes, EDS, CIRS, neck issues, and other sources of stress can cause dysautonomia , which cause gastroparesis and/or gut motility issues which lead to gut dysbiosis, and other CFS or ME Septad issues. In these cases FMT may only offer temporary relief.
@@RobMatch-ev1qx There is a bi-directional axis, but the scientific literature overwhelmingly shows that FMT can restore function. The Human Microbiome wiki has lots of info on this. For example, the SIBO page has lots of studies showing the gut microbiome regulates motility. If FMT only provides temporary relief the issue is likely donor-quality or needing to clear the gut mucosal lining first.
As I mention in the talk, do not try any treatments because they are on this list. Many of these compounds do not have even basic safety testing in humans, and some of them have never even been tried by a human. This list is solely to show the types of things I am considering for further investigation. Thanks! - Jarred Younger
May I suggest pentoxifylline? If hypoxia is the cause of microglia malfunction, rather than the result, pentoxifylline makes RBCs more flexible, so they can carry oxygen through constricted arterioles and reach capillaries that might be otherwise blocked. Brand name: Trental. I do not know whether it crosses the blood-brain barrier, but it has been successfully used for decades to improve oxygenation in lower extremities with peripheral arterial disease.
@@AniBAretz pretty sure ozone therapy does the same thing with RBC flexibility and also greatly increases the delta between RBC oxygen saturation and oxygen depletion i.e. increases the amount of usable oxygen in the blood. (Ozone therapy increases a-vO2)
is the difference between minocycline and doxy that significant? They used to only do minocycline in the Marshall Protocol, is that why?
@@AniBAretzI am currently 5 weeks into an 8-week course of Pentoxifylline (400mg 3x daily) as an experiment (under medical supervision) for ME/CFS. I would describe myself currently as physically severe (98% bed bound according to FUNCAP55) and cognitively moderate (thanks to LDN). On paper, Pentoxifylline made a lot of sense and my doctor was willing to prescribe it, but results have been disappointing thus far, it hasn't moved the needle in any of the ways I was hoping for. Obviously this is anecdotal, N=1 etc ..
You need to add heparin and low molecular weight heparin to your list.
Please never stop posting videos. You’re doing a huge service to all of us struggling with CFS/Fibromyalgia that we’re all thankful for. It’s good to see new research being done in this area and making your findings public for all of us to learn from.
I suffer from severe me/cfs in the aftermath of a covid infection. I just wanted to say thank you. You are one of my heroes for working on this and being so transparent with us patients.
The only doc that is actually doing the work to find what is wrong with us 😢 thank you
That’s impossible because there many different subsets/root causes, dozens if not hundreds. You’ve been lied to by Reddit and forums saying there’s one ME/CSF and it’s the only thing that can cause PEM.
Thanks for sharing! You are setting a great example. Sad to see that low-dose transdermal nicotine is not on your list since it seems to tic all the boxes.
Your push for open-decentralized research methods is fantastic! Keep it up!
Thanks. I am adding nicotine to the list because of its effects pushing M1 to M2 microglia states. - Jarred Younger
@@youngerlab Great to hear! Thanks for all you do!
Thanks for your transparency and commitment to treating/curing this horrible illness
Happy to do it. Thanks -- Jarred Younger
you're a great beacon of hope, and so compassionate and understanding of the experience of the one suffering from these conditions. to see a list like this is so soothing, you have no idea!
Or as the German foreign minister says, a bacon of hope! 🥓
Always good to see people working to make things less opaque
I was given Amantadine for a different condition and it made a major change in my neuropathy and fibromyalgia symptoms, especially pain, strength, and fatigue levels. I did find out the hard way that the brand of the generic makes a huge difference (Upsher-Smith has been the best out of Strides and Activis, which was the worst performer). My best friend who has very similar diagnoses as me had the same experience. It definitely seems to be affecting Neuro inflammation but I don’t see many studies on it outside of MS and Parkinson’s.
This experience has also made me wonder how many times people tried a medicine that would have worked for them but because of the differences in how generics are made they abandoned the medication instead of tried different brands. This is the fourth medicine I’ve had this issue with.
I have this issue with migraine meds. There have been problems with generics labs, so i'm (dismayed but) not surprised at your experience. Interested and glad to read amantidine was helpful for you!
Amantadine has some interesting actions on microglia. I am adding that one to the list. Thanks! I made a note about the generic brands. Generics can use different processes to get to the final compound, but they are supposed to be exactly the same - for sure with U.S.-based manufacturers. We do purity testing on the medications we use to make sure is what we expect. If amantadine made it to the top of the list, I would probably get some from different suppliers to test. - Jarred Younger
You have ALL my respect and support.
Thanks!! - Jarred Younger
Thank you for this. My me/cfs Dr has me trialling rampamycin as he thinks it has potential. Early days so nothing to report except that it hasn't made me worse which is always a relief
Thank you for taking time to list these and to warn against experimenting with them.
I'm on LDN. Didn't help fatigue or cognitive issues, but does help me get quality REM sleep.
Which is a win in itself.
Thanks for letting me know! - Jarred Younger
Feels like theres more knowledge and expertise in this video and comment section than i encounter in MANY places
Dr. Younger is a researcher. Most of us have been following him for some time.
Great video and list 👍 some additional suggestions (all very powerful for the mentioned purpose): TUDCA (must have), Plasmalogens (e.g. ProdromeGlia), Fisetin (BBB fixer), Luteolin, Naringin (brain iron chelator), Gamma-Tocopherol (brain ROS killer), Lycopene, Ecklonia Cava extract (phlorotannins), Holy Basil, Olive Leaf Extract, Sodium Butyrate, Magnesium-Ascorbate or -Threonate, Glycine. For restoring Focus & Productivity (after calming down inflammation) : Safron extract & Lions Mane.
Thank you for all your ongoing research efforts. If only we had more people like you!
Thank you. I am so grateful that you care enough to take the time to show us the possibility. I believe you and your team will find our answer.
The info and data in your vlogs give us something to hope for and to not feel forgotten. Thank you!
Amazing. Hope the best ones can help! Thanks
Awesome to hear a list! Thank you for your determination!
Jarred, this is great! Seeing the 3 slides of potential treatments on the horizon, I'm feeling more hopeful than ever. What matters to patients like me is whether effective treatments are on the horizon, and how soon they may become available, and you obviously understand the dire need for treatments. Thank you!
I am intently curious how our near infra red-starved lifestyles, largely devoid of regular exposures to daylight (particularly the NIR), plus the similar experimental laboratory NIR-starved environments, might need to overlay the quantum biology of light issues into this assessment? Low D3, low NIR inducement of mitochondrial exposure benefits for structured water energy function and melatonin production, may be essential to understand along with these important inflammation understandings? Our switch to too much indoor LED lighting (cutting out the NIR from incandescent lighting), appears maximally problematic for increasing inflammatory effects as well? No?
More scientific understanding of quantum biology of light quality seems essential in approaching such research list potential benefits for humanity. Daylight exposure, carefully done, is essential for consideration given this 'dire need' for emerging treatments IMHO
Great information and great work keep digging
Thank you so much Dr Younger for taking the time to make these videos, and of course for all the amazing research that you do 💜
Thank you for your work.
Thank you so much for all you do
Thank you for your work, Dr. Younger
😃 - Jarred Younger
Thanks Doc! ❤
Sure thing! - Jarred Younger
Oh, I hope you will include CRPS! I have been dealing with this nasty condition for 20+ years! I, also have myasthenia gravis (and salicylate allergies) which makes it a challenge for participating in trials... but it may be interesting to see if they are interconnected.
The differential diagnosis between CRPS and ME/CFS and/or Fibromyalgia and CRPS would be great to know if the treatments you find to address glial cells and their involvement in the experience of pain and physical limitations.
I sure hope you get the funding for a Centre. That would be a game changer. But I hope there are avenues other than the NIH seeing how they neglect and spite these conditions still.
Indeed!
What thoughts do have on dorsal root ganglia inflammation? Thanks for your work.
It seems likely there is DRG involvement in ME/CFS, and very likely in fibromyalgia. It is tricky to do studies with DRG in living humans. I am trying to get whole spine in my PET studies so we can get at least an idea of the spinal cord involvement. I would suspect DRG involvement when the initial instigating event occurred in the periphery rather than the brain, and when abnormal pain sensitivity is involved. - Jarred Younger
Methylene Blue works incredibly well for my ME/Long-COVID/MCAS brain inflammation. 10mg allows me to play video games for a few hours (impossible without it) and when I combine it with 0.5mg Ketotifen it allows me to safely eat things that would otherwise cause instant anaphylaxis. It also fully counteracts the drowsiness from Ketotifen. Seriously underrated compound. 🔵
Are you dosing orally or intravenously?
@@nickdriver8337 drinking 10 drops in a 250ml glass of water.
@@SamuelxShaban I would love to hear where you get it! And do you prepare it yourself? I got some in 2022 but I havent trusted the source.
@@Dalf-x5m Science(dot)bio nootropics. Using Shipito to forward it to Netherlands. Whatever source you pick, always check the purity testing reports by 3rd party labs. Never trust uncertified compounds.
Can you take it long term?
There's a large subset of we with me/CFS that have toxin overload and genetic errors in the ability to methylate and detoxify and have gotten worse after taking medications. If a promising medication is found many will rush to try it and I fear the outcome. I hope the possible drug can be used short term or work so well that it supercedes the need to protect ourselves from chemicals and toxins.
Not sure this is relevant, or not, but the use of photon light treatments versus medications needs to be explored and made more available, especially through insurances.
No it shouldn’t, just assume you need sunlight and go get some
@@eddie8489 Thank you for the feedback. I have a problem with being in direct sunlight for more than just a few short minutes. I can handle the shade, but direct light can cause weaknesses that are debilitating... I do take D3 and K2, however.
@@mercy3219 same exact thing with me!! Even a few minutes puts me down for an hour with weakness, inability to think or speak, fatigue. I’m actually post sunlight now so I’m about to go through hell. I really think it has to do with excessive vasodilatory response.
@@eddie8489 I have myasthenia gravis which has a known connection to sunlight sensitivity. You might consider seeing a neurologist -- it can become quite a serious situation if you have it (or Lupus, or other undiagnosed issues). Take care, please.
Keep in mind, a variety of other conditions that have overlapping features with ME-CFS (and this rogue gallery) involve negative responses to sunlight: Porphyrias, Dermatomyositis, Lupus, etc.
Not saying either of you have these conditions but the other mechanisms should be contemplated when troubleshooting for this spectrum of disease [pun intended].
Last tidbit, I think aside from a negative immune response (adaptive or innate) as a possibility, there is also an interesting energy requirement and chain of events when receiving sunlight. I first consider the precursor for Vit D production: 7-dehydrocholesterol. These energy/metabolic cycles are always reasonably in the discussion with ME-CFS.
EDIT: I just saw your comment about having MG. I have a similar crossover with MG, Sjogren’s, Lupus and more. Almost like MCTD. It is brutal (100% bedbound in my 30s; came on suddenly at the end of 2020, likely after Covid or similar infection).
Thank you this sounds very encouraging.
I have severe long covid for 4,5 years and was a little recovering every year. But few months ago I had a tick bite (neurological sadly) but I’m now on Minocycline and it’s helping my long covid! It’s difficult bc I now have also Lyme symptoms and a lot of adrenaline. But certainly my long covid lifted a bit but I don’t know how it’s on the long run. I had this also with doxycycline and a little with naproxen. Less tired and less PEM, more clear in my head. I think it lifted inflammation in my brain. But coming off the doxycycline was difficult back then.
I had 4 ops on my teeth all under general anaesthetic but after one of those ops I came home and felt no ME/CFS symptoms my head was clear, I had energy and my posture was upright even my parents said “what’s going on with you you look like your old self” woke up next day and was back to ME/CFS. So out of those 4 ops there has got to be one different drug that was used that made me “normal” I can send you all 4 anaesthetic report as I cannot understand it.
Thank
Interesting, I had GA for wisdom teeth and it was the best sleep I ever had, I felt lovely and refreshed. EDS patients have a different response to anaesthesia and opioids.
Thank you so much for your work and for sharing info. It's both fascinating and hopeful to a sickie like me. :)
You're welcome! - Jarred Younger
Dr Younger, love your work! Just wondering if you have any views on neuromodulation for ME/CFS and long covid? And in particular the use of vagal nerve stimulation? There seems to be dome theoretical basis for this, given issues of neuroinflammation, brain connectivity etc in the illnesses. Thanks
Thank you for this 'open' approach! IMHO, searching across specialties and broadening 'peer review' exposure seems prerequisite for best scientific method toward more fruitful outcomes. I have recently come to understand need for approaches considering quantum biology knowledge as a bedrock to inform QA/QC for such important effort. Lab subjects are all evolved by having adapted over untold thousands of years to thrive outdoors. The complexities involved in their physiologies, we are only 'scratching the surface of'. The energy carried in the orchestra of daylight breadth of wavelengths sustains physiology complexity. Lab environments, lit by LEDs and fluorescent light, w/o benevolent modulation of 'what was left outdoors' really DOES need to be accounted for. Lab animal physiology (especially human), is essentially and thoroughly tied to the physics effects of the specific light reaching it. Shinning toxic isolated narrow bands of wavelengths biases the resultant outcomes of testing. Best wishes for your work, onward and upward into the light.
On the list under hormones, I would highlight 'mitochondrial melatonin' as well as pineal melatonin. Also, Vitamin D3 hormone plus its other active forms produced in daylight. Dr, casey Peveler on YT has summaries of research on these as presentation videos.
Bacillus subtilis helped someone I know very much (1 teaspoon of powder 2x day on empty stomach, but sometimes more). They used Vitamatic brand from Amazon in the USA.
Best first option would be the Low dose Naltrexone (other type that you mentioned in previous videos). Also anything that inhibits EBV.
Jarred, thanks for all your work and research. Can I ask a question? Are there ME/CFS researchers like you in the UK who do clinical trials similar to what you do? I'd love to apply to be in a trial if it's available anywhere near to where I live.
The person I know best is Katharine Seton - I think she is in Norwich. She should know about active clinical trials. - Jarred Younger
@@youngerlab Thanks for this. I hope in the future there are more and all over both our countries.
SO excited & interested to hear this.Thank you very much 😊
Thank you. Very humble response.😊
Thanks for sharing this goldmine of a list!
What are your thoughts on urolithin A? no place for it on the list?
It is a dynamic list - I'm adding to it all the time! I can go to a page 4. :-) I've seen the peripheral immune effects for a few years now, but the evidence of microglia effects is just now coming out. It should pass the BBB, so it is an interesting compound I will look at further. - Jarred Younger
That's interesting. While I'm not familiar with how clinical trials are typically designed, it seems a bit outdated to apply the same treatment to everyone with a chronic disease, especially when the condition can manifest differently in each person. With today's technologies, such as knowledge graphs and machine learning, we have more advanced options that could lead to more personalized treatments, potentially combining botanical solutions with drugs. These approaches could also improve safety outcomes and save time.
Thank you for this list. Good to see such a wide variety of dugs & supplements on it 😊 Have tried quite a few of them over the years. LDN helped my ME-driven insomnia for a while, then gradually stopped working, so I abandoned it bc it's too expensive. Dextromethorphan is great; takes the edge off of the worst payback/PEM. Still have to rest & pace though!
@youngerlab Would you consider inversion as a potential home-remedy/therapy for increasing oxygen to the head/brain if done responsibly? For example: laying down on an inversion table for two minutes, twice a day?
I am on LDN I noticed a little at the beginning but not anymore. It didn’t help my fatigue at all. Wish there was something that would help that.
Helped me with pain for a period of time then completely stopped worked. Very interesting drug, wish my body didn’t figure it out.
I'm still trying to get a synthetic chemist to make dextro-naltrexone, a compound I hope will hold its effects in people where normal LDN does not. But it will be a while before it is available for testing. I hope you are able to find other things to help! - Jarred Younger
@@youngerlab Will there be a way to stay abreast of future trials that might use this drug? Do you imagine it would be only be ME/CFS diagnosed patients? Jumping the gun here but would love to be part of this since LDN worked so well for me for a time.
I was put on candarsatan for my hypertension but had urinary issues. Hard to empty the bladder. So I was put back on losartan. But my GP messed up the convertion and put me on a too small dose than what my cardiologist prescribed.
So I was on the same dose as before I got to the cardiologist.
My systolic BP hovered around 135 and my GP thought that was fine and told me to take walks but I couldn't. I then switch GP and realized the mistake my former GP had done. So my new one doubled the dose. Then I got very sick and she let me have another 24h measurement and increased the dose even further.
As long as I'm under 120/80 I felt pretty good and could take pretty long walks all of a sudden. But I get really dizzy if the systolic BP reaches like 130/90. On this medication I get like equally dizzy at 130/90 as if I was on no medication had 145/105.
It seems losartan and a blood pressure at under 120/80 make me way less fatigued.
Sometimes I believe my ME mainly came from the fact no one treated my hypertension to begin with. They just assumed my BP was elavated because I was in a medical setting when it was tested or something.
But I need to mention I also started having B12 injections, folinic acid and iron in combination when increasing the dosage.
But with B12 or not I'm really sensitive to blood pressure changes. If I'm concentrating really hard on something like nailing a hard guitar solo or stuff like that, the sudden spike in blood pressure can make me really dizzy and fatigued still.
So it must be tied to like hyper focus, and maybe stress hormones. I wonder if like alpha blockers would combat that?
Methylene Blue has been around for a long time but all of the testimonials are anecdotal. Thoughts on researching it for ME/Dysautonomia?
I'm using MB currently and it's s done wonders. I do like LDN better, but I'm not able to take it currently . The issue I have is MB is detoxing parasites faster than my body is currently able to handle, so I've had to slow down on it.
I was also wondering if he'd bring this up in his research
@@tammyrobinson1613 I didn't realize it was an anti-parasitic. I tried LDN once at the lowest dose but reacted badly to it so am not willing to try it again. Thank you for the heads up re: MB.
Thank you for sharing and being diligent.
I really can't say how good black seed oil can be .
Thymoquinone is a very strong part of black seed .
It stopped my pots and adrenic response for months
Are there any plans to look into finding the root cause of the inflammation?
Exactly this. I think gut dysbiosis + intestinal permeability causing immune system deficits is likely a major root cause. FMT addresses this root cause so I was very disappointed to not see FMT listed. I emailed him about it recently as well.
Look in to EDS and the Mechanical Basis of CFS by Jeff Woods, and Scott Rosa
You don't need to worry about me testing any of them, because starting to improve after nearly 3 decades and none of which I'm taking (just the mainstream minerals and vitamins but the gist is in balancing the amounts and forms) are on there 🙃 If you take just one or a few things then I'm sure your list is helpful!
Except for selenium of course, there's a bit of that in the multivitamins.
LDN, along with relaxing my nervous system; addressing very low thyroid using NDT, and doing trauma work has helped a lot. There's still a missing piece to get me more than 70%
Seeing 2 antibiotics on the list may confirm an experience I had a year ago. Back story: We live in an area with a lot of feral cats. In the process of transferring a feral cat for neutering, I got a nasty scratch, which led to sepsis.
I have had 1 round of antibiotics in my adult life (tick bite) 30 years ago. The sepsis from the cat scratch led to a necessary penicillin injection and rounds of 2 different orally dosed antibiotics; which lasted for 2 weeks.
I don't do well with anything injected, so I spent 3 days in bed with a flu-like reaction. But after that, I noticed that I had no pain. None. Not in my joints, not in my muscles.
I asked the Functional Medicine Dr. I was seeing at the time. He had no theories or explanations to offer.
These types if events are fascinating. Frustrating you couldn't get some to dig deeper. I'm not sure if you're associated with them, but your experience sounds similar to what the Remission Biome project folks experienced- just mentioning in case you haven't connected with them.
@@marskristin Thanks for the feedback. I'll look them up.
Dextromethorpan has nearly eradicated all of my cognitive PEM. I still have brain fog but I’ve been able to read, be on my computer all day, chat with friends, and watch movies without the intense pressure/cotton headed feeling. I first noticed it from taking Robitussin.
Thank you so much for your work. I discussed taking DXM with my me/CFS literate doctor who is on board. We discussed the potential mechanisms and discovered that it inhibited microglial activation. He mentioned that ketamine might also work similarly but I haven’t heard much else about that.
It helps me a lot (physically rather than cognitively) but not to the extent that I can increase my activity level or stop pacing. It just reduces some of the fallout.
Yes it helped me with headaches. But my stomach started hurting and the effects has not been as strong as before 😔
Which patients do you want to include in your trials? ME or CFS?
I have tried Rapamycin 5mgs once a week for 8 weeks. For the first 4 weeks I thought I had finally found a drug to control M.E ,then it all went down hill and the M.E symptoms came back just as bad. So I stopped.
Sensory nerve damage is important too from virus hence ME and to have such a terrible reaction to sound is extremely difficult to bear. No doctor has ever tried to help my case. “ neuralgia” of the brain and ears from the other side of the tympanic membrane and uninflected but some sort of disorder that interrupts thoughts too. Ugh! No flying or scuba diving didn’t cut it.
May i ask: LPS means lipo poly sacharide?
Yup, Look up Patrick Nemechek for a theory of where this can come from.
@@RobMatch-ev1qx Thank you very much!:-)
I would really like Methylene Blue and Low Dose Naltrexone studies to be more conducted. LDN is kind of a double edged sword, as it usually works for cca. 50% of the patients.
What is your opinion on TUDCA, CBD (or even THC), NADH and L-Carnitine?
Both of those you mention specifically are in my top 10 to investigate. I've also submitted grants for CBD and looked into THC. The other chemicals I haven't looked into closely because I always considered them more critical for basic cellular processes rather than microglia modulation. But I have another list of interesting compounds that don't involve microglia modulation specifically. - Jarred Younger
@@youngerlab Thanks, Jarred!
Besides CBD and THC, have you studied CBDV (Cannabidivarin)? That cannabinoid molecule also has anti-inflammatory and even neuroprotective properties?
Is there a way to donate to your lab?
Pay your taxes
Starting to see some interesting research finding on red light therapy (PBM), especially when combined with ketogenic diet
Help, have you seen any studies on ozempic for IBS and inflammation? I started on it and it has been almost a miracle. Thanks
So how is the immune system then going to fight the enterovirus in ME?
What is the connection, if any, between neuroinflammation and mitochondrial dysfunction which is purported to be a key driver of MECFS? Thanks for your work!
Mito dysfunction and inflammation are a vicious circle with ROS in the middle. The proximate cause could be CSF flow issues, gut dysbiosis, or many other things.
Hello. Any chance you can look into peptide ss-31 and give your 2 cents regarding it might being something very useful once more research is done. It looks great on paper. Thanks so much
“56.7 autoimmune thyroglobulin antibodies” these were my abnormal test results- what should I do? Thank you
If someone is supposed to start rosuvastatin anyway for high ldl, for your opinion, is the potential in low doses as well? the potential is for standalone or as part of polypharmacology?
Can we please try rTMS for CFS?
Bee venom therapy seems to be the only thing that cures people. Johns Hopkins sent me a letter to be on a clinical trial for monocycline last month.
Outstanding, Dr. Younger!
Note that TLR4 is upregulated in neurocysticercosis
surprised not to see psilocybin here
Sounds like this is tailor-made for AI / Super computer to have a bash at ... if nothing else thinning your list would be a positive outcome.
Are you trying to put him out of a job? Anyway, I think you'd still need someone to coordinate and actually run the testing, that is until we have humanoid robots who can do all this?!!!
@@mattpotter8725AI is just a tool, it helps the human not replace it.
@@mattpotter8725 as Dr. Younger said in the video, it would take several lifetimes to properly trial everything on his list, AI could help narrow down what the most promising candidates might be.
I tried ChatGPT only once. I wanted to turn one of my scientific publications into Stephen King style. It didn't work. :-/ I like the idea of AI interpreting and organizing the published data in unique ways. I could contract that task out and see what they came up with. I haven't been keeping up with the academic/scientific versions of AI. I just know the advances are occurring at a dizzying pace. - Jarred Younger
@@youngerlabme biting my lip thinking about hindsight in some areas of technology…lol
It’s such a shame to see such effort be applied in an insufficient manner. There have been case studies of people who have been cured. There are specific doctors who have had REALLY good success. It’s like you’re starting at square one in trying to build “aHiroshima” meanwhile other countries already built it or have done the work, and are the majority there. Once I’m done fully curing my case, I’ll have to put everything I’ve found together in a presentation or something
Not saying your work isn’t worth it nor good. I believe what you’re working with will and can help in A LOT of ways. Would it it help map out damage/repair pathways? Yes. Could that help eventually lead towards valuable and useful information? Yes. Could it help symptom patching for people with little to no hope; most certainly. But it doesn’t find/address the actual cause. Had to add this reply because I wasn’t trying to say your work is for nothing.
Curious what country has done the work and have a majority recovering? Or a majority of any answers on causation or treatment. Researchers around the globe are collaborating on 'square one' trials & studies. If there is valid, peer reviewed scientific data from any country I have yet to find it & would be most grateful
All you need is oxaloacetate. All inflammation markers down. Even experienced nerve regeneration from damage 24 years ago from Bells Palsy. No long term use required. It HEALS.
When i looked it up, it was way too expensive for the big dose
With all due respect and genuine gratitude for your work, I must say that I find it extremely disappointing that you've chosen not to go more in-depth in the substances that you are highly considerate of being an effective treatment - Given the lack of resources, that are at our disposal, to even imagine testing all of these various compounds is unfortunately out of scope, hence why it's very reasonable to prioritize the most promising ones, that goes without saying, though especially with the limiting research that has been conducted, getting the word around, the ones that show great signs of effectiveness, might cause the wonder people are desperately waiting for.
Changing my diet saved me from debilitating back pain, nerve pain, joint pain, muscle pain, digestive issues, raised blood pressure, 20kg over weight. It took around 8 months for all these problems to resolve. I'm completely pain free and never felt and looked healthier.
Since 2020 I've only been eating fatty meats, seafood, eggs and dairy.
Prior to that I was eating the mainstream version of a healthy diet (lots of veggies, fruit, whole grains, low fat, eating the rainbow etc) for decades and watching my health slowly decline.
Dr Anthony Chaffee, Dr Paul Mason, Dr Ken Berry, Dr Shawn Baker, Dr Gary Fettke, Dr Benjamin Bikman, Dr. Malcolm Kendrick, all helped me get my health back.
I've thoroughly experimented with diets for the last 3 years. Ketogenic zerocarb is the best for pain specifically.
You and Pedro Pascal has the same voice lol
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why you doing lots of question marks ?
Why isn't FMT listed? None of these seem likely to cure CFS. They might be able to treat some of the symptoms. None of them address the root cause of CFS, which is likely gut dysbiosis + intestinal permeability causing immune system disfunction. FMT addresses that root cause.
My ME/CFS resulted from the over-use of oral antibiotics, which caused major gut dysfunction. But I went through FMT and it had no effect. :(
@@PhillyGuy7575 FMT is highly donor-dependent. High-quality donors are extremely rare. I've screened 1.2m+ people to find good donors, but I need help from the medical and research communities.
There can be other root causes, EDS, CIRS, neck issues, and other sources of stress can cause dysautonomia , which cause gastroparesis and/or gut motility issues which lead to gut dysbiosis, and other CFS or ME Septad issues. In these cases FMT may only offer temporary relief.
@@RobMatch-ev1qx There is a bi-directional axis, but the scientific literature overwhelmingly shows that FMT can restore function. The Human Microbiome wiki has lots of info on this. For example, the SIBO page has lots of studies showing the gut microbiome regulates motility. If FMT only provides temporary relief the issue is likely donor-quality or needing to clear the gut mucosal lining first.
Our list for ME is entirely different, btw, and has been for decades But who is listening.
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