Something I forgot to mention - when the average cerebral perfusion level is 37.6, that means (roughly) half of the participants had lower than that number. Some of the participants in this study indeed had more severe hypoxia. - Jarred Younger
I think you should look at EDS ehlers danlos syndromes. Connective tissue syndromes. I think that is an underlying genetic cause. Pots dysautonomia fibromyalgia, me cfs,ms, parkinssons huntingtons, Als graymatter whitematter disease postinfectious/ autoimmune disease. And many many more things.....I have been writing a lot about this sinne the covid panemic started. Also written to researchers to make them focus on this. I have serched for studies about the things involved ,genemutations causing the problems like weak connective tissue streatchy veins, coagulation problems, mastcell activation, endothelial damage, immunedefects, healing problems, scarring, inflammation heartproblems lung problems gut problems. And so on......
@@mariawallstrom4731 Maria, interesting information. I'm not a doctor, but your post triggered what I have read about statins and the dementia relationship. Also, a known side effect of statins is tendon ruptures (much like the antibiotic Ciprofloxacin). And, going one step further, the new statin replacement (since statins are off-patent and not the revenue stream they once were), Nexletol...which shares the tendon rupturing side effect.
I have long-covid/chronic Lyme. Started using oxygen one year ago and it drastically improves my ability to function in life, physically and mentally. I also moved and feel much better at 300 ft above sea level than I did at 3000 ft. This is the first time I’ve seen any mention of low O2 perfusion being connected to symptoms of brain fog and fatigue. I had just stumbled upon it by chance. I tried it at an IV Spa and felt my brain clear up and headache go away almost instantly. I now use it for 30 minutes at bedtime and in the morning. My sats on a pulse oximeter have never been low. Thank you Dr. Younger for sharing your research with us all.
@@liliha986 I did a 60 day two hour a day, supine oxygen protocol and in the end, all my breathing of oxygen without the hyperbaric chamber, turned out to be an incredible disability. It ends up, causing your breathing system to become dysfunctional. It took me quite a while to recover from my normal oxygen protocols.
@@chutechi so sorry to hear that. I felt if I went over 30 minutes at a time, it was too much. But 30 minutes was just right. I’m curious, what are your normal protocols?
This is something I intuitively feel with my chronic fatigue of undetermined origin. The hypoxia-like fatigue. Just imagine conveying this to your doc, however - mentally ill!
What I did was take astaxanthin (to help counter oxidative stress), baby aspirin (to counter a little bit Microclots, which are found in ME CFS etc patients per some studies but idk if I had them I can only suppose, meloxicam, and I stood on a shaker machine every day for 5 minutes-15 minutes every hour as much as I could. I kept my circulation being raised and stimulated all day to prevent the settling of the supposed microclots. It significantly relieved the shortness of breath and eventually all my symptoms. I was early in the disease development which probably made a difference but if you can get a shaker machine and can stand vibration please try it. I had the same issues with doctors.
Other studies using doppler radar to measure blood flow to the brain showed that healthy controls had about 4% lower flow when standing compared to lying down, while ME/CFS patients had 24% lower flow when standing. If your tests show that the patients with chronic illness start with lower perfusion in the brain than healthy controls, that's a double whammy... and no wonder that cognitive issues are a significant issue!
@@davidrumsey3180 yes the tilt table tests, which were showing low blood volume problems continued to be affecting problems for me, which I offset by eating, tremendous amounts of salt and water that managed to keep up the orthostatic intolerance now these blood flow problems would certainly contribute to low oxygenation
🙏🏼Deepest gratitude to Dr Younger, Ms Chloe Jones and the rest of the team working to find answers and solutions. These illnesses have been largely ignored by the medical establishment for so long. It gives me hope to see a research lab taking it seriously. Thanks for sharing your findings with us.
@@ashleylala4293 I worked with Dr. Lahman and Dr. Joanne Whitaker, who were pointing out that the testing protocols in general for Lyme disease were so poor that the government should make massive changes in its testing regulations of protocols. I think that was 30 years ago.
To me what's most relevant about this sort of thing is the max flux rate (of oxygen in this case) which will directly determine what level of brain activity is supported and what level of heightened activity leads to a drop-off in functionality. I.e. it seems obvious that with lowered perfusion you might feel just fine when "doing nothing" but quickly hit a wall when socializing, speaking, reading, thinking, standing, moving, etc.
@@BanzoUnchained exactly! Thank you for pointing out & articulating that.. is part of what's been confusing me, trying to gauge what I can cope with, does feel like hitting a wall, as you say, & considerable 'recovery' time seems to be required
@@BanzoUnchained the oxygen model to the brain certainly makes sense to me concerning exertion and recovery time because if there’s some sort of dysfunction of oxygen in the brain, it looks like it’s slow recovery because it’s slow to get the oxygen
Thanks for sharing so quickly, Jarred 😊 I think it's really interesting that GWS vets have low supine profusion, as (if I recall correctly) some of their symptoms are the opposite of PWME. I have ME, and my BP used to drop when I was upright. It doesn't seem to do that now - yet my mind goes empty when I'm upright too long, and sometimes I gasp for breath when I lie down again - exactly as it did before. Such a complex damn disease! Cheers from Melbourne Australia 😊
Wow this is very exciting research! A friend with long covid got an oxygen concentrator at an estate sale and it has worked wonders for her. Thinking of one myself though my long covid is more mild than hers.
You would have thought with all the lung issues with LC that extra oxygen might be of extra help here, as opposed to maybe not as much help with ME or GWI
I’m a 20+ year chronic fatigue chronic Lyme disease patient with an extensive background in research and interestingly enough one of the most effective things I’ve ever done is owning my own hyperbaric chamber
Yes, High-pressure oxygenation of blood plasma is one of the few direct patient-passive treatments I find to help with ME/CFS (if not with long-term pain), among other disorders of organs with parts that have blood-constricted areas, like the kidneys. Of course, American insurance companies refuse to pay for it except in certain cases of crush injuries, blood-gas problems, and, rarely, the odd cancer case. Because the equipment and compressed-oxygen costs are high, full courses of these treatments remain out of reach for most people on an out-of-pocket basis. Personal ownership would be even more unattainable for typical sick people. But it is good fortune for you to have this resource.
I bet you anything standing on a vibration machine may work well as a stand in at least for a lot of people. It stimulates blood flow into your capillaries really heavily
@@bitegoatie yes. I could talk about protocol’s but correct you need a bunch of treatments. I also did a german treadmill oxygen protocol that was amazing.
Do people with GWI tend to have hypocapnia? Hypocapnia can result in cerebral hypoperfusion. People with ME often have hypocapnia, and it is assumed that this is due to hyperventilation. However, a study [Natelson et al. 2022] found that people with ME/CFS were not breathing rapidly, so hypocapnia was assumed to be due to overly deep breathing - but they did not actually measure breath volume. Hypocapnia in ME might not be due to a breathing issue, but rather a respiration (metabolism) issue.
I remember reading research regarding oxygen metabolism being affected by neurological mediation. I know early on as my doctor was developing my diagnosis I had episodes becoming unusually short of breath during intense physical exertion during recreational activities, exercise, and sometimes during times of intense exertion while working my various jobs. My doctor ordered a pulmonary work up which was generally normal. As I aged I had sleep studies which showed I had 02 saturations dropped below 90 while asleep. This was before I developed obstructive sleep apnea. I was on CPAP for several years but still had 02 saturation below 90. I am very slim and have no other pulmonary metabolic issues and no explanation for the low 02 stats. I have been on 2 liters supplemental 02 at night. Sometimes during the day my 02 sats will drop to lower 90s without exertion while resting awake reading or watching TV. I discovered that taping my mouth at night worked just as well as CPAP and prevented any obstructive apnea while sleeping but I still have low 02 sats while sleeping so I continue with supplemental 02. My doctors have described it as idiopathic hypoxia secondary fibromyalgia.
ME/CFS patient here, just a heads up if you are using marijuana to help you sleep it will lower blood ox while sleeping. I stopped the MJ use and despite the insomnia coming right back I am feeling better and my whoop is showing higher blood ox at night. Hope this helps.
Even as a non-scientist, this makes a lot of sense to me. If a Gulf War soldier was exposed to chemicals, the body would try to protect the brain. Would it accomplish this by inflaming the arteries to the brain or throwing up some kind of blockade? This could also explain the mold-cfs connection. When I’m feeling my worst, the back of my neck feels hot and inflamed, I have a hard time breathing, and I have yawning fits, like my body is desperate to get more air. Dr. Younger, you’re on to something and I can’t wait to hear more! Thank you for all that you do.
@@gailhaugen6212 golf course syndrome was a biological weapon that our government sold to the enemy who used it on us unfortunately, the progression of that condition leaves to Lou Gehrig’s disease, many cases
Yeah I just checked the computer chugging away at processing data from about 100 people. It takes the computers days sometimes to run all the analyses. - Jarred Younger
I have a friend who was treating fibromyalgia by breathing exercises and head movement. His thesis was that the shape of the circle of willes was impacting the blood oxigen in the brain.
It seems to me that in the last four years, more relevant research results in GWI has been conducted and presented than in the previous 29 years. Work done at Mass General Hospital, Nova Southeastern, UTSW and UAB have narrowed down what has happened and is happening to ill Gulf War Veterans. Even resent research conducted in Australia suggests calcium ion channel inhibition as a contributing cause. Thank you.
Thank you for this! It makes so much sense. As an ME sufferer of 29 years, I feel there are also other areas, organs & tissues that are not getting enough oxygen. It seems to almost be at a cellular level. My O2 levels are normally about 94 but how much of that is getting to where it needs to go??
IHT (Intermittent Hypoxia Therapy) and IHHT (Intermittent Hypoxia-Hyperoxia Therapy) induce adaptations like angiogenesis (new blood vessels), more red blood cells, increase of stem cells, increase of telomere length, etc that allows for the normalization of brain hypoxia. This kind of therapy can be done with an altitude training machine (similar to an oxygen concentrator), that machine has an outlet of air with less oxygen and another outlet with more oxygen. Every other day you breathe 45 minutes with a mask alternating 5 minutes of less oxygen and 3 of more oxygen. That is the usual dosage used in scientific experiments published in pubmed. It is cheaper than the HBOT (hyperbaric oxygen therapy) which partly works due to this hyperoxia-hypoxia paradox.
Doesnt good breathing practise help? I apparently often have low oxygenation when i sleep (says Fitbit) & oximeter on finger shows variable but goes up to normal /good when I breathe deeper & more consciously. Very interesting point about lying down v sitting v standing. (History of structural/head injuries, CFS & endocrine & gut dysbiosis, late diagnosed (aged 48 female) autism & adhd & cptsd. Had "glandular fever like virus" aged 20, showed in blood tests for 3yrs. And lots of stress, & sugar/carb addiction... so many other factors to consider also, sleep, movement, ltmph, hydration etc) Thank you for looking into all this & helping make sense
There are functional PET scans which show isolated regions of lactic acidosis in patients with ME/CFS. - particularly after appropriate stress. This is highly likely to be predictive of reduced local tissue flow, is it not?
In the body or the brain? I god these ediagnosis but it seems to have resolved since taking magnesium but I did find deep breathing really helpful for my muscular pain more so even than drinking water and excercis.i couldn't excercise because of the pain and breathing really deeply before hand helped me to be able to move my muscles which then helped me get stronger so I could excercise more and get some endorphins. I recently read that the brain uses lactic acid ..I always thought it was just a think your muscles made and made them tight if you didn't have a hot shower or something
I also wondered if ADHD individuals predominantly suffer with very low blood pressure. I have ADHD & always have low blood pressure even when I don't feel dizzy. If I don't exercise most days I feel lethargic & depressed & have aches and pains. If I do some sort of cardio I feel switched on mentally and physically I feel amazing
@@nickibanks5185there is research tying the gut microbiome to adhd. Look up the original GAPs diet book. It is a yellow cover, thick and written by a neurologist from Europe somewhere.
Yes. Very informative! Thanks for sharing! There are smaller devices that can measure bloodflow to the brain (doplar ultrasound?). And it appears to be common to see one side more affected than the other side. That would be interesting to see in your results... if the two sides could be compared? I assume you are also checking for physical blockage from CCI or Chiari issues? But those might not be evident on the prone scans.
Good points. My colleagues use the dopler ultrasound for diagnosing orthostatic intolerance issues. I haven't used them, but I will consider incorporating them into my studies if I find hints of perfusion issues in the ME/CFS and fibromyalgia groups. My structural scans are appropriate for assessing Chiari malformation, but I didn't position the participants optimally in the scanner. - Jarred Younger
I am a 67 year old woman with sleep apnoea, During a medical procedure with a spinal block, the anaesthetist had to keep reminding me to breathe more deeply as my oxygen levels were dropping. I have to wonder how often this happens as often I tend to choke, feeling unable to take a breath. I already have memory problems from insomnia from side effects of mental health medication.
I was the same way. My oxygen levels were 80 and I couldn’t think. Had to retire early from my teaching career. Was on a c-pap for years until I had my breast implants removed. Now I have Lyme. Hell for 21 years.
Fantastic research Dr. Younger! 🎉 ❤ Right of the bat I can think of 2 treatments: 1. Cpap like tx. at night with possible O2 added. 2. Hyperbaric chamber. This tx. is only covered by insurance in treatment of burn patients- so far. Hoping this and other research changes that. Wonderful! Thanks 🙏👍‼️😘
Have you tested your patients for biomarkers for CIRS (mold toxins, Shoemaker protocol)? Also SIBO may be an explanation for the inflammation (Proprionoate, LPS).
The breath has everything to do with the circulation of cerebral spinal fluid and the ionization of the inner surfaces of the ventricles and the symmetry of the cerebral cortex and balance of the cranial nerve function.
It would be great to see some descriptive statistics for the patients and controls and for the future cohorts too. I’ve curious as to the size of the overlap between the groups and whether there is sufficient difference for this to potentially be a diagnostic measure (sensitivity/specificity).
I haven't used it, but my overall read of the literature is there is enough support to warrant trying it. I think a subset of FM sufferers would benefit from improved brain blood flow. The downside is that many (probably expensive) treatments would be needed, and I assume maintenance sessions would be needed. You might need at least 10 sessions before you can start to assess if it is helping. - Jarred Younger
I just met with the radiology team three days ago. We had to address one more issue of running male healthy subjects through the protocol, and we got that handled. I am scheduling the first ME/CFS person now -- they haven't undergone the scan yet. Soon! - Jarred Younger
With my me/cfs I notice I always want to have my head totally flat in bed. I've suspected its a blood flow/O2 issue. I also get air hunger which feels my brain is suffocating.
I too am desperate to explain the air hunger, it feels neurological. I also have uncontrollable yawning fits in the absence of being tired. No doctor has ever been able to explain it.
@@daphne4983 Sort of but I have no anxiety involved nor respiratory or cardio issues. Its like a neurological need to breath hard at times due to distress.
@@baileystruss7319That's very interesting. I don't think I have CFS but I do have polymyalgia rheumatica with extreme fatigue (and perhaps some crossover with CFS) and I sometimes get that air hunger you refer to. And I have found that venlafaxine (antidepressant/antianxiety med) is very helpful but several times when I inappropriately decreased the dose I had (possibly) anxiety-derived hyperventilation for the first time in my life. Perhaps these are two different but related phenomena. I'm just trying to add information to the discussion for what it's worth.
Use Google scholar to look up me CFS microclots. I countered it with astaxanthin (to counter oxidative stress), baby aspirin, meloxicam (to tamp down inflammation some) and standing on a shaker machine as much as i could stand (or sit) every hour for several minutes. It stimulates circulation, without exertion, and it would slowly relieve the air hunger, good phrase for that. After several months I had a huge turnaround. I think the shaker machine was the game changer though
Can I just mention the elephant in the room? Liver problems. Low liver function equals slower blood flow due to loss of detoxification capability equals less blood flow to the brain and therefore lower oxygen levels?!
Doplar ultrasound is the way to go for that. A clinician who specializes in autonomic disorders would probably have a good setup for that. - Jarred Younger
I'm curious. Are there any non-profits near DC that your team works with? It seems like there is a lot of great research in your field and I worry that the research is not being communicated to doctors and policy makers within Washington. From what I've heard about the long covid hearings in congress, it sounds like they do not have a good understanding of what long covid even is. I wonder if there is a better way to communicate the research people like you do to the general public. BTW, I do think the TH-cam channel is a great start. I really appreciate all of the effort that has been made to make this information accessible to people without a background in medical research
Lots of potential options - I will cover many in upcoming videos. Check the one I did recently on Pycnogenol. It works well for peripheral and central blood flow. - Jarred Younger
I’ve been told my brain looks like I’ve had a tbi, been struggling with fatigue and sensitivity issues, stimulation issues, abnormal reactions to meds, for years. However, I’ve never had blunt force type trauma and it was from a spect scan from controversial amen clinic. So, I really don’t know. I know I’ve been suffering for a long time and I think dysport injections (botulinum) pushed me over the edge. But honestly, I have no idea what’s been going on with me.
SPECT is good for assessing cerebral blood flow abnormalities, but it doesn't answer the question of why blood flow is impaired. I don't think it is the best for making an assessment of TBI. MRI and PET/CT would be better for that, in my opinion. There are many things that could be causing the symptoms you are describing. I wouldn't want to guess, but you may want to follow the videos because I will be covering many of the possibilities and how they are likely to be treatment. I hope you are able to find a way to resolve this condition. - Jarred Younger
I’m curious to know if you have tested the Gulf War Illness patients for chemical toxicities such as bromopropane, perchlorate, dioxins, and radioactive toxins?
I just listened to the latest on this @JARRED YOUNGER Knowing about the loss.of choline (Pemt and bhmt issues )Ive been taking various forms.of.choline to assist. I ALSO.TAKE F. PINE BARK 400MG (PINUS PINASTER W PEPPEREINE) is this the form of pine bark you are speaking of? ??? 1 more question...is the test you speak of avail to the public????? Would serum levels give me a clue???. Its been a long journey since 2011. I would also like to THANK YOU tremendously for your work on LDN...on it since 2013. Im still rockin 2 knees 1 of which is bone on bone. I am forever grateful for your devotion to making our lives livable. Carry-on with Blessings from NJ.
What do you think are the drivers of the low blood perfusion and low oxygen? Do you ever look at VEGF levels? I've struggled with issues from biotoxin illness. My VEGF levels were very low.
I hypothesize the low blood prefusion is due to exposure to non-reversible acetylcholinesterase inhibitors in the Persian Gulf War. If I see the same thing in ME/CFS and fibromyalgia, I will have to look into other possible causes. I do test VEGF in my studies. Usually, though, I am seeing elevated levels due to systemic inflammation or brain damage. VEGF helps increase blood supply to inflamed regions. Both high and low VEGF are problematic. Low VEGF can cause significant problems with fatigue, weakness, and cognitive impairment (among other things). - Jarred Younger
Hi Jarred. Tissue Hypoxia , inc cereblar hypoxia is a common finding in chronic illness- Lyme, long covid , fibro, mitochondria disfunction inc those caused by chemicals. IV ozone or hyperbanic oxygen can be really helpful but also finding and treating a cause
That all fits with what we're seeing in the lab. I've never conducted a Lyme Disease study, but I wouldn't be surprised if there are commonalities with the other conditions. - Jarred Younger
Would IV ozone or hyperbaric oxygen treatment be something that would help in a permanent sense in that it promotes increase vessel growth? Or would you say it'd be more temporary where it would be supplementary long-terms as the root cause isn't addressed.
Cerebral perfusion is a fairly standard clinical scan -- there are MRI and PET approaches, but I prefer the MRI because there are no injections. Any standard 3T (or even 1.5T) strength scanner should handle it. - Jarred Younger
Did you account for heart rate and age of the participants or their physical activity levels, hemoglobin or anemia? Of course if a subject's heart is beating faster, then more blood and, thus, more oxygen will be diffusing across the blood brain barrier throughout the brain (all else being equal).
Dyspnea, or shortness of breath, is common in Chronic Fatigue Syndrome. It might result from respiratory trauma, which might alter the breathing pattern permanently, leading to shallow breaths when the person is not consciously controlling their breathing.
Thankyou lots of factors, causing or affecting diff pathways. What about delivery of oxygen to brain via haemaglobin, how does it change during the day, with exercise, with deep breathing, how is it linked to blood pressure or overall health ie cardio vascular health atheroscerlosus, what is causing low blood orifusion which factors poor breathing patterns over months years little aerobic exercise, low ferritin level etc etc, toxins what biochemical pathways?
I think your questions are on a similar track to mine. Along with haemoglobin is it's capacity to deliver blood (bohr effect), the overall blood viscosity, and vascular constriction/relaxation.
absolutely! This is why stellate ganglion block and HBOT improved cerebral blood flow and resolved a lot of cognitive issues and malaise for me and my ME/CFS. this makes complete sense for me.
@@liliha986 i did one series of 20 one hour sessions over a month at 1,5 ata and at first i felt immediate but transient symptom relief from the added oxygen, then gradually i started feeling worse, until the end of the treatment where i felt like some symptoms had gotten worse, but it seemed as if it was just my immune system ramping up. i felt crappy for a month, then i had a couple of kambo sessions that gave relief for a couple days, then it disappeared. after that i gradually started to improve slightly, then during an LSD session there was some phase transition to a new stable state where i have been symptom free and able to move without PEM, for 13 weeks now!
@@daphne4983 it's a nerve block they put in your stellate ganglion, it inhibits the sympathetic nervous system and floods the brain with blood! it reduced sensory sensitivity and cognitive impairments and emotional flatness, it has also calmed down some immune responses and gave me my deep sleep back.
Is there contact information for you? I am a 57 year old female with diagnosed migraines. In May I woke in the night with severe head pain. I was screaming and running into walls. I was very dizzy and my toes went numb. Once the hospital controlled the pain, I realized that my short term memory was gone. I couldn't complete a sentence because I would forget what I was saying. After 3 days my memory started to get better. Then I had a repeat a week or so later. It has happened a few times since ,to a lesser degree. This is extremely scary. They released me from the hospital without knowing what was wrong. I have not fully recovered. I can't drive because I forgot where I am going. My blood pressure has been low the last 2 times 80/63. Something is truly wrong but I don't have a doctor helping me. I did see a neurologist who ruled out MS. I was diagnosed with CF and fibromyalgia in 2005. I don't know what is happening, but I really need help and can't find anyone local.
Thank you for your amazing research! I'm not an expert but was thinking about reginal hypoxia (RH), leading to a range of major or minor changes in brain function. You mentioned tumor or trauma as causality, but what about "micro" strokes? Could they not also lead to RH and hence a decline, however minimal it may be, in brain function and hence cognitive changes. And then of course the consideration of successive micro strokes (months or years) leading to an increase in areas (same or different) of RH and hence decreased brain function over time, perhaps with very minor symptoms following each micro stroke. All in all, a progressive cognitive decline that's barely recognizable, if at all. Thoughts? Best regards.
Definitely there could be a cumulative effect of repeated transient ischemic attacks. One problem with tracking the TIAs is the MRI-based T2* or DWI scan may reveal the TIA only if acquired directly after the event. Then they heal (structurally) and look normal, but could leave a pocket of inflammatory activity by activated microglia. The microglia activity doesnt show up on the clinical scans. So, this problem is probably being missed in most cases. Another issue I am looking at is enlarged perivascular spaces. The PVCs are generally considered to be benign, but I'm not sure. I believe we see more in those with chronic pain, fatigue, and cognitive dysfunction, but I have to do more work to determine that for sure. - Jarred Younger
@@youngerlab Thank you for your informative reply. I hope your research continues to yield insightful results. The work that you're doing is very important.
Your location is listed on YT as “BIRMINGHAM.” Just a suggestion: you might be at UAB (Alabama) or elsewhere including UK (Birmingham, UK). Etc. You are on a global platform. Your content is interesting. I’m not sure what else to make of it “yet,” but I wish to see more. (Cutting edge discussions, like these,)
Thanks for letting me know. When I choose the location for the video, it does distinguish between Birmingham in the U.S. and the U.K., but then the difference isn't noted when the video is posted. I'll see if I can force the extra info to appear next time. I'm in the newer Birmingham, not the original. - Jarred Younger
Absolutely. I wish more people with ME/CFS and FM could have a proper sleep study to rule out sleep apnea. Most individuals with it are undiagnosed. I did a video about a year ago on how people can test for sleep apnea if they are unable to get a proper study done. th-cam.com/video/GRquu4_Zzsk/w-d-xo.html - Many people would find significant symptom improvement by fixing a chronic hypoxic problem at night. Thanks for mentioning it. - Jarred Younger
Hi I've had sleep apnea for the past 15yrs and been on cpap for that time first couple of months were brilliant thereafter knackered everyday after watching your vlogs my blood oxy levels are spiking up/down how can I resolve them?
Looking for a good synthetic chemist still. Everyone is so busy since the lockdowns and the chemists have their hands full producing new compounds for researchers. I contacted two more possibilities last week and am exploring options with them. I found someone with a small bit of the compound, but it is for animal use only, so that doesn't help me. I'm still working on it! - Jarred Younger
This is why pulse oximetry needs An overhaul in emergency settings. I had severe neurological symptoms due to this and they were ignored due to pulse oximetry being fine. Also melatonin fixes it.
Has anyone tried the Mendi meditation / neurofeedback headband? It works by measuring perfusion in the prefrontal cortex. Could neurofeedback training cause PEM in people with ME/CFS?
Have you identified any testing methods that are in clinical use bearing pathognomonic results ie specific for ME/CFS I dread shotgun style medical testing because most doctors don't know that stress testing can destroy you for weeks and I'm still working fulltme
Thank you. My O2 says are always 98-100% on a pulse oximeter. Is this something that would not be captured in an 02 sats reading? I’ve always suspected low o2 to the brain to explain many of my symptoms but doctors all look at me like I’m crazy.
@@rdklkje13 one is oxygen in your blood, the other is where that blood is getting to. Probably impacted by inflammation, endothelial function/dysfunction, blood pressure, orthostatic tolerance. But probably best to leave explanation to the expert. I believe this is why stimulants help with my brain fog. It’s also why I treat myself with anything that may decrease inflammation (steroids, antihistamines, therapeutic apheresis, cryotherapy, anti-inflammatory diet etc) and increase perfusion (HBOT, compression, counter postures, recumbent exercise within energy envelope etc)
Would continuous wear of a surgical mask such as a 3M Aura 1870+ Flat Fold Particulate Respirator/Surgical Mask for prolonged periods say an eight or 12 hour shift lower brain oxygen levels? Do you know of any studies on this topic?
sure would, and part of the plandemic to reduce oxygen ....like the cell towers, and being addicted to smart tech, antisocial medial scrolling = breath holding, shallow breathing, and radiating.The masks were part of that. I was a nurse working pre and intra plandemic. When the masks went on, that is when I got very sick with mold toxicity and severe covid. I'm still damaged, but yes oxygenation is huge. And they are reducing it.
You commented that you didn’t expect people to have specific areas with poor flow rates. I may have missed something - but suggest that the initial insult to the brain from (for example) an autoimmune response to a virus which has temporarily targeted a sub-population of brain cells - would result in concentrated damage to that area. It sounds a little like you are convincing yourself of the lack of need to have high-resolution investigation of specific brain area blood flow because of your current technology limitation. Beware of that thought process! Keep up the great work 😊👍
You're right - we can't discount reasonable possibilities. We are running the local analyses right now - it just takes longer to compute and interpret than the whole-brain numbers. It is possible that each individual has different local regions, so they wouldn't emerge in a group average. But if a region comes up significant in the patient group as whole, that would be very interesting. Thanks! - Jarred Younger
Something I forgot to mention - when the average cerebral perfusion level is 37.6, that means (roughly) half of the participants had lower than that number. Some of the participants in this study indeed had more severe hypoxia. - Jarred Younger
Exciting to have results coming in! Did all of the GWI participants have low brain oxygen? (And all controls have >50?)
Check for right vs left brain activity in these PPL.
Did I miss this in the video? Were the O2 sats all normal in your subjects? So does this point to a profusion issue? Or is there a third explanation?
I think you should look at EDS ehlers danlos syndromes. Connective tissue syndromes. I think that is an underlying genetic cause. Pots dysautonomia fibromyalgia, me cfs,ms, parkinssons huntingtons, Als graymatter whitematter disease postinfectious/ autoimmune disease.
And many many more things.....I have been writing a lot about this sinne the covid panemic started. Also written to researchers to make them focus on this. I have serched for studies about the things involved ,genemutations causing the problems like weak connective tissue streatchy veins, coagulation problems, mastcell activation, endothelial damage, immunedefects, healing problems, scarring, inflammation heartproblems lung problems gut problems. And so on......
@@mariawallstrom4731 Maria, interesting information. I'm not a doctor, but your post triggered what I have read about statins and the dementia relationship. Also, a known side effect of statins is tendon ruptures (much like the antibiotic Ciprofloxacin). And, going one step further, the new statin replacement (since statins are off-patent and not the revenue stream they once were), Nexletol...which shares the tendon rupturing side effect.
I have long-covid/chronic Lyme. Started using oxygen one year ago and it drastically improves my ability to function in life, physically and mentally. I also moved and feel much better at 300 ft above sea level than I did at 3000 ft.
This is the first time I’ve seen any mention of low O2 perfusion being connected to symptoms of brain fog and fatigue. I had just stumbled upon it by chance. I tried it at an IV Spa and felt my brain clear up and headache go away almost instantly. I now use it for 30 minutes at bedtime and in the morning. My sats on a pulse oximeter have never been low.
Thank you Dr. Younger for sharing your research with us all.
Oxygen tank? Like sporters use ?
@@daphne4983 I purchased an oxygen concentrator off Amazon.
@@liliha986 I did a 60 day two hour a day, supine oxygen protocol and in the end, all my breathing of oxygen without the hyperbaric chamber, turned out to be an incredible disability. It ends up, causing your breathing system to become dysfunctional. It took me quite a while to recover from my normal oxygen protocols.
@@daphne4983 oxygen concentrator
@@chutechi so sorry to hear that. I felt if I went over 30 minutes at a time, it was too much. But 30 minutes was just right. I’m curious, what are your normal protocols?
This is something I intuitively feel with my chronic fatigue of undetermined origin. The hypoxia-like fatigue. Just imagine conveying this to your doc, however - mentally ill!
What I did was take astaxanthin (to help counter oxidative stress), baby aspirin (to counter a little bit Microclots, which are found in ME CFS etc patients per some studies but idk if I had them I can only suppose, meloxicam, and
I stood on a shaker machine every day for 5 minutes-15 minutes every hour as much as I could. I kept my circulation being raised and stimulated all day to prevent the settling of the supposed microclots. It significantly relieved the shortness of breath and eventually all my symptoms. I was early in the disease development which probably made a difference but if you can get a shaker machine and can stand vibration please try it.
I had the same issues with doctors.
@@barrybrennan2135 Doctors? Who goes to Doctors for this?
@@chutechi Did we not all try once? Twice? Three times, etc 😁
They would say “it’s all in your head” LOL
@@SohailSiadat or it's probably stress .... smh
Thanks Jarred - your efforts in sharing developments is appreciated.
As a family member of someone severely affected by chronic pain/fatigue I look forward to the day these efforts you describe yield fruit for patients.
@@eleuron its been 20+ years for my wish
Other studies using doppler radar to measure blood flow to the brain showed that healthy controls had about 4% lower flow when standing compared to lying down, while ME/CFS patients had 24% lower flow when standing.
If your tests show that the patients with chronic illness start with lower perfusion in the brain than healthy controls, that's a double whammy... and no wonder that cognitive issues are a significant issue!
Holy cow!
@@davidrumsey3180 yes the tilt table tests, which were showing low blood volume problems continued to be affecting problems for me, which I offset by eating, tremendous amounts of salt and water that managed to keep up the orthostatic intolerance now these blood flow problems would certainly contribute to low oxygenation
@@sexywarriorwomen I second that holy cow!
🙏🏼Deepest gratitude to Dr Younger, Ms Chloe Jones and the rest of the team working to find answers and solutions. These illnesses have been largely ignored by the medical establishment for so long. It gives me hope to see a research lab taking it seriously. Thanks for sharing your findings with us.
@@ashleylala4293 I worked with Dr. Lahman and Dr. Joanne Whitaker, who were pointing out that the testing protocols in general for Lyme disease were so poor that the government should make massive changes in its testing regulations of protocols. I think that was 30 years ago.
To me what's most relevant about this sort of thing is the max flux rate (of oxygen in this case) which will directly determine what level of brain activity is supported and what level of heightened activity leads to a drop-off in functionality.
I.e. it seems obvious that with lowered perfusion you might feel just fine when "doing nothing" but quickly hit a wall when socializing, speaking, reading, thinking, standing, moving, etc.
@@BanzoUnchained exactly! Thank you for pointing out & articulating that.. is part of what's been confusing me, trying to gauge what I can cope with, does feel like hitting a wall, as you say, & considerable 'recovery' time seems to be required
@@BanzoUnchained the oxygen model to the brain certainly makes sense to me concerning exertion and recovery time because if there’s some sort of dysfunction of oxygen in the brain, it looks like it’s slow recovery because it’s slow to get the oxygen
Amazing findings! Thank you for making it available as it goes. We are so lucky to have these sharing before peered reviewed
Thanks for sharing so quickly, Jarred 😊 I think it's really interesting that GWS vets have low supine profusion, as (if I recall correctly) some of their symptoms are the opposite of PWME. I have ME, and my BP used to drop when I was upright. It doesn't seem to do that now - yet my mind goes empty when I'm upright too long, and sometimes I gasp for breath when I lie down again - exactly as it did before. Such a complex damn disease! Cheers from Melbourne Australia 😊
Wow this is very exciting research!
A friend with long covid got an oxygen concentrator at an estate sale and it has worked wonders for her. Thinking of one myself though my long covid is more mild than hers.
You would have thought with all the lung issues with LC that extra oxygen might be of extra help here, as opposed to maybe not as much help with ME or GWI
Thank you for making these videos. You explain things so well, even I, a brain-fogged, scientifically challenged patient can understand them.
I’m a 20+ year chronic fatigue chronic Lyme disease patient with an extensive background in research and interestingly enough one of the most effective things I’ve ever done is owning my own hyperbaric chamber
Yes, High-pressure oxygenation of blood plasma is one of the few direct patient-passive treatments I find to help with ME/CFS (if not with long-term pain), among other disorders of organs with parts that have blood-constricted areas, like the kidneys. Of course, American insurance companies refuse to pay for it except in certain cases of crush injuries, blood-gas problems, and, rarely, the odd cancer case. Because the equipment and compressed-oxygen costs are high, full courses of these treatments remain out of reach for most people on an out-of-pocket basis. Personal ownership would be even more unattainable for typical sick people. But it is good fortune for you to have this resource.
I bet you anything standing on a vibration machine may work well as a stand in at least for a lot of people. It stimulates blood flow into your capillaries really heavily
Have you tried a liver flush?
@@bitegoatie yes. I could talk about protocol’s but correct you need a bunch of treatments. I also did a german treadmill oxygen protocol that was amazing.
@@artosbear tried that and it works well in beginning then does nothing. I think once it dislodges whatever then your done
This has been my hypothesis personally for the past couple years
Do people with GWI tend to have hypocapnia? Hypocapnia can result in cerebral hypoperfusion. People with ME often have hypocapnia, and it is assumed that this is due to hyperventilation. However, a study [Natelson et al. 2022] found that people with ME/CFS were not breathing rapidly, so hypocapnia was assumed to be due to overly deep breathing - but they did not actually measure breath volume. Hypocapnia in ME might not be due to a breathing issue, but rather a respiration (metabolism) issue.
I remember reading research regarding oxygen metabolism being affected by neurological mediation. I know early on as my doctor was developing my diagnosis I had episodes becoming unusually short of breath during intense physical exertion during recreational activities, exercise, and sometimes during times of intense exertion while working my various jobs. My doctor ordered a pulmonary work up which was generally normal. As I aged I had sleep studies which showed I had 02 saturations dropped below 90 while asleep. This was before I developed obstructive sleep apnea. I was on CPAP for several years but still had 02 saturation below 90. I am very slim and have no other pulmonary metabolic issues and no explanation for the low 02 stats. I have been on 2 liters supplemental 02 at night. Sometimes during the day my 02 sats will drop to lower 90s without exertion while resting awake reading or watching TV. I discovered that taping my mouth at night worked just as well as CPAP and prevented any obstructive apnea while sleeping but I still have low 02 sats while sleeping so I continue with supplemental 02. My doctors have described it as idiopathic hypoxia secondary fibromyalgia.
@@inspectorraycharles are lucky to have doctors that could figure that out
ME/CFS patient here, just a heads up if you are using marijuana to help you sleep it will lower blood ox while sleeping. I stopped the MJ use and despite the insomnia coming right back I am feeling better and my whoop is showing higher blood ox at night. Hope this helps.
Good to know
@@Mazzzaq well this could be part of a larger mechanism, which seems to mess up our sleep patterns
Even as a non-scientist, this makes a lot of sense to me. If a Gulf War soldier was exposed to chemicals, the body would try to protect the brain. Would it accomplish this by inflaming the arteries to the brain or throwing up some kind of blockade? This could also explain the mold-cfs connection. When I’m feeling my worst, the back of my neck feels hot and inflamed, I have a hard time breathing, and I have yawning fits, like my body is desperate to get more air. Dr. Younger, you’re on to something and I can’t wait to hear more! Thank you for all that you do.
@@gailhaugen6212 golf course syndrome was a biological weapon that our government sold to the enemy who used it on us unfortunately, the progression of that condition leaves to Lou Gehrig’s disease, many cases
Excited about this study. Thanks Dr. Younger
This is really cool, Dr Younger, thanks for sharing. Can’t wait to hear the results in ME/CFS patients and learn about potential treatments!!
Yeah I just checked the computer chugging away at processing data from about 100 people. It takes the computers days sometimes to run all the analyses. - Jarred Younger
I have a friend who was treating fibromyalgia by breathing exercises and head movement. His thesis was that the shape of the circle of willes was impacting the blood oxigen in the brain.
yes. the same I found out some weeks ogo.
Circle of willies? What is that?
Would be interested to know how this correlates to POTS, hypovolemia and Orthostatic intolerance.
You are an absolute angel! Waiting on tenterhooks for next week’s results too
It seems to me that in the last four years, more relevant research results in GWI has been conducted and presented than in the previous 29 years. Work done at Mass General Hospital, Nova Southeastern, UTSW and UAB have narrowed down what has happened and is happening to ill Gulf War Veterans. Even resent research conducted in Australia suggests calcium ion channel inhibition as a contributing cause. Thank you.
Perhaps new understanding due to covid research?
Thank you, Dr. Younger! 😊
Looking forward to the follow-ups to this study. Although I have FM, I’m curious how they all compare.
Thank you for this! It makes so much sense. As an ME sufferer of 29 years, I feel there are also other areas, organs & tissues that are not getting enough oxygen. It seems to almost be at a cellular level. My O2 levels are normally about 94 but how much of that is getting to where it needs to go??
IHT (Intermittent Hypoxia Therapy) and IHHT (Intermittent Hypoxia-Hyperoxia Therapy) induce adaptations like angiogenesis (new blood vessels), more red blood cells, increase of stem cells, increase of telomere length, etc that allows for the normalization of brain hypoxia. This kind of therapy can be done with an altitude training machine (similar to an oxygen concentrator), that machine has an outlet of air with less oxygen and another outlet with more oxygen. Every other day you breathe 45 minutes with a mask alternating 5 minutes of less oxygen and 3 of more oxygen. That is the usual dosage used in scientific experiments published in pubmed. It is cheaper than the HBOT (hyperbaric oxygen therapy) which partly works due to this hyperoxia-hypoxia paradox.
Thank you!!!
Doesnt good breathing practise help?
I apparently often have low oxygenation when i sleep (says Fitbit) & oximeter on finger shows variable but goes up to normal /good when I breathe deeper & more consciously.
Very interesting point about lying down v sitting v standing.
(History of structural/head injuries, CFS & endocrine & gut dysbiosis, late diagnosed (aged 48 female) autism & adhd & cptsd. Had "glandular fever like virus" aged 20, showed in blood tests for 3yrs. And lots of stress, & sugar/carb addiction... so many other factors to consider also, sleep, movement, ltmph, hydration etc) Thank you for looking into all this & helping make sense
Art Of Living S.K.Y . take a look there for me it helped ..
Thank you for explaining this study clearly. Keep up the good work!
Have there been any studies obn CPAP or BI PAP at night for these conditions?
Qigong lower dantien focused practices improve diaphragmatic movement which assists brain oxygenation - feels so good after too
There are functional PET scans which show isolated regions of lactic acidosis in patients with ME/CFS. - particularly after appropriate stress. This is highly likely to be predictive of reduced local tissue flow, is it not?
In patients with ME. 'ME/CFS' is a misnomer for some random symptoms.
In the body or the brain? I god these ediagnosis but it seems to have resolved since taking magnesium but I did find deep breathing really helpful for my muscular pain more so even than drinking water and excercis.i couldn't excercise because of the pain and breathing really deeply before hand helped me to be able to move my muscles which then helped me get stronger so I could excercise more and get some endorphins. I recently read that the brain uses lactic acid ..I always thought it was just a think your muscles made and made them tight if you didn't have a hot shower or something
Have you considered also testing ADHD patients for cerebral inflammation and/or hypoperfusion?
I also wondered if ADHD individuals predominantly suffer with very low blood pressure. I have ADHD & always have low blood pressure even when I don't feel dizzy. If I don't exercise most days I feel lethargic & depressed & have aches and pains. If I do some sort of cardio I feel switched on mentally and physically I feel amazing
@@nickibanks5185there is research tying the gut microbiome to adhd. Look up the original GAPs diet book. It is a yellow cover, thick and written by a neurologist from Europe somewhere.
Yes. Very informative!
Thanks for sharing!
There are smaller devices that can measure bloodflow to the brain (doplar ultrasound?). And it appears to be common to see one side more affected than the other side. That would be interesting to see in your results... if the two sides could be compared?
I assume you are also checking for physical blockage from CCI or Chiari issues? But those might not be evident on the prone scans.
Good points. My colleagues use the dopler ultrasound for diagnosing orthostatic intolerance issues. I haven't used them, but I will consider incorporating them into my studies if I find hints of perfusion issues in the ME/CFS and fibromyalgia groups.
My structural scans are appropriate for assessing Chiari malformation, but I didn't position the participants optimally in the scanner. - Jarred Younger
Why is there no mention of the control group result? You've only given half the story.
This makes so much sense! Thank you Dr Younger!
Thank you as ever for these videos
Thanks! - Jarred Younger
I am a 67 year old woman with sleep apnoea, During a medical procedure with a spinal block, the anaesthetist had to keep reminding me to breathe more deeply as my oxygen levels were dropping. I have to wonder how often this happens as often
I tend to choke, feeling unable to take a breath. I already have memory problems from insomnia from side effects of mental health medication.
I was the same way. My oxygen levels were 80 and I couldn’t think. Had to retire early from my teaching career. Was on a c-pap for years until I had my breast implants removed. Now I have Lyme. Hell for 21 years.
Fantastic research Dr. Younger! 🎉 ❤ Right of the bat I can think of 2 treatments: 1. Cpap like tx. at night with possible O2 added. 2. Hyperbaric chamber. This tx. is only covered by insurance in treatment of burn patients- so far. Hoping this and other research changes that. Wonderful! Thanks 🙏👍‼️😘
When you check certain areas for low perfusion, it would be interesting to compare those areas with the areas you looked for inflammation.
Have you tested your patients for biomarkers for CIRS (mold toxins, Shoemaker protocol)? Also SIBO may be an explanation for the inflammation (Proprionoate, LPS).
Frequently it's viral in origin
The breath has everything to do with the circulation of cerebral spinal fluid and the ionization of the inner surfaces of the ventricles and the symmetry of the cerebral cortex and balance of the cranial nerve function.
It would be great to see some descriptive statistics for the patients and controls and for the future cohorts too. I’ve curious as to the size of the overlap between the groups and whether there is sufficient difference for this to potentially be a diagnostic measure (sensitivity/specificity).
thoughts on hyperbaric oxygen chambers for fibromyalgia
?
I haven't used it, but my overall read of the literature is there is enough support to warrant trying it. I think a subset of FM sufferers would benefit from improved brain blood flow. The downside is that many (probably expensive) treatments would be needed, and I assume maintenance sessions would be needed. You might need at least 10 sessions before you can start to assess if it is helping. - Jarred Younger
Thank you very much 🙏
This is so obvious to me from personal experience 😅
Do you happen to have any updates on the zirconium-89 brain scans for ME/CFS? Thanks!
I just met with the radiology team three days ago. We had to address one more issue of running male healthy subjects through the protocol, and we got that handled. I am scheduling the first ME/CFS person now -- they haven't undergone the scan yet. Soon! - Jarred Younger
With my me/cfs I notice I always want to have my head totally flat in bed. I've suspected its a blood flow/O2 issue. I also get air hunger which feels my brain is suffocating.
I too am desperate to explain the air hunger, it feels neurological. I also have uncontrollable yawning fits in the absence of being tired. No doctor has ever been able to explain it.
Is that hyperventilating?
@@daphne4983 Sort of but I have no anxiety involved nor respiratory or cardio issues. Its like a neurological need to breath hard at times due to distress.
@@baileystruss7319That's very interesting. I don't think I have CFS but I do have polymyalgia rheumatica with extreme fatigue (and perhaps some crossover with CFS) and I sometimes get that air hunger you refer to. And I have found that venlafaxine (antidepressant/antianxiety med) is very helpful but several times when I inappropriately decreased the dose I had (possibly) anxiety-derived hyperventilation for the first time in my life. Perhaps these are two different but related phenomena. I'm just trying to add information to the discussion for what it's worth.
Use Google scholar to look up me CFS microclots. I countered it with astaxanthin (to counter oxidative stress), baby aspirin, meloxicam (to tamp down inflammation some) and standing on a shaker machine as much as i could stand (or sit) every hour for several minutes. It stimulates circulation, without exertion, and it would slowly relieve the air hunger, good phrase for that. After several months I had a huge turnaround. I think the shaker machine was the game changer though
It would be fascinating to make participants exercise before testing then see what their perfusion levels would be.
Can I just mention the elephant in the room? Liver problems. Low liver function equals slower blood flow due to loss of detoxification capability equals less blood flow to the brain and therefore lower oxygen levels?!
Do you have any recommendations? I think you may be onto something for many of these patients.
Agreed...The liver is causing me similar symptoms and I now know I must begin a detoxification process. Thank you for the extra confirmation✨
Sugar, alcohol, obesity and other liver irritants also affect the brain directly.
@@The_Savage_Wombat With ME you should avoid sugar and alcohol.
My brain works 100% better laying down. So really would be interesting to see blood flow standing up.
Doplar ultrasound is the way to go for that. A clinician who specializes in autonomic disorders would probably have a good setup for that. - Jarred Younger
C4a c3a levels that are high are causing vaso constriction.
I'm curious. Are there any non-profits near DC that your team works with? It seems like there is a lot of great research in your field and I worry that the research is not being communicated to doctors and policy makers within Washington. From what I've heard about the long covid hearings in congress, it sounds like they do not have a good understanding of what long covid even is. I wonder if there is a better way to communicate the research people like you do to the general public. BTW, I do think the TH-cam channel is a great start. I really appreciate all of the effort that has been made to make this information accessible to people without a background in medical research
What are normal blood oxygen levels while sleeping?
Did the participants have normal blood pressure? Could problems with BP impact blood flow to the brain? Also, were blood clots ruled out?
Thank you so much for sharing this important information in a clear and timely manner!!!!!❤
Dr Younger. I am surprised that you did not use the term POTS in your video. 🤔
What was the average cerebral perfusion score of the control group?
Why did he not say?
What potential treatments?
Lots of potential options - I will cover many in upcoming videos. Check the one I did recently on Pycnogenol. It works well for peripheral and central blood flow. - Jarred Younger
If someone had an Mri and Mra 2 years ago, would low oxygen show up if those records were reviewed? The Imaging facility gave us a DVD of the tests.
I’ve been told my brain looks like I’ve had a tbi, been struggling with fatigue and sensitivity issues, stimulation issues, abnormal reactions to meds, for years. However, I’ve never had blunt force type trauma and it was from a spect scan from controversial amen clinic. So, I really don’t know. I know I’ve been suffering for a long time and I think dysport injections (botulinum) pushed me over the edge. But honestly, I have no idea what’s been going on with me.
SPECT is good for assessing cerebral blood flow abnormalities, but it doesn't answer the question of why blood flow is impaired. I don't think it is the best for making an assessment of TBI. MRI and PET/CT would be better for that, in my opinion. There are many things that could be causing the symptoms you are describing. I wouldn't want to guess, but you may want to follow the videos because I will be covering many of the possibilities and how they are likely to be treatment. I hope you are able to find a way to resolve this condition. - Jarred Younger
I’m curious to know if you have tested the Gulf War Illness patients for chemical toxicities such as bromopropane, perchlorate, dioxins, and radioactive toxins?
I guess pathogens are also involved.
I just listened to the latest on this @JARRED YOUNGER Knowing about the loss.of choline (Pemt and bhmt issues )Ive been taking various forms.of.choline to assist.
I ALSO.TAKE F. PINE BARK 400MG (PINUS PINASTER W PEPPEREINE) is this the form of pine bark you are speaking of? ???
1 more question...is the test you speak of avail to the public?????
Would serum levels give me a clue???.
Its been a long journey since 2011.
I would also like to THANK YOU tremendously for your work on LDN...on it since 2013. Im still rockin 2 knees 1 of which is bone on bone. I am forever grateful for your devotion to making our lives livable. Carry-on with Blessings from NJ.
I’m so sorry. I’m ill as well. 21 years and counting with a cascade of problems and pain beginning with breast implants, mold, now Lyme.
Yep! Right on point. Thx yes mine is low chronically too.
What do you think are the drivers of the low blood perfusion and low oxygen?
Do you ever look at VEGF levels? I've struggled with issues from biotoxin illness. My VEGF levels were very low.
I hypothesize the low blood prefusion is due to exposure to non-reversible acetylcholinesterase inhibitors in the Persian Gulf War. If I see the same thing in ME/CFS and fibromyalgia, I will have to look into other possible causes.
I do test VEGF in my studies. Usually, though, I am seeing elevated levels due to systemic inflammation or brain damage. VEGF helps increase blood supply to inflamed regions. Both high and low VEGF are problematic. Low VEGF can cause significant problems with fatigue, weakness, and cognitive impairment (among other things). - Jarred Younger
Any thoughts on what exactly is causing this? Thank you for your work!
Hi Jarred. Tissue Hypoxia , inc cereblar hypoxia is a common finding in chronic illness- Lyme, long covid , fibro, mitochondria disfunction inc those caused by chemicals. IV ozone or hyperbanic oxygen can be really helpful but also finding and treating a cause
That all fits with what we're seeing in the lab. I've never conducted a Lyme Disease study, but I wouldn't be surprised if there are commonalities with the other conditions. - Jarred Younger
Would IV ozone or hyperbaric oxygen treatment be something that would help in a permanent sense in that it promotes increase vessel growth? Or would you say it'd be more temporary where it would be supplementary long-terms as the root cause isn't addressed.
@BlizzGo help with what ?
@@Dobrusska Help with the items you mentioned. Chronic illness- Lyme, long covid , fibro, mitochondria disfunction, CFS, brain fog, etc.
ASL fascinating!
Can any modern MRI machine do this? Software update?
Never inject the toxic contrast dye.!
MRI Gadolinium Toxicity Support group online
Cerebral perfusion is a fairly standard clinical scan -- there are MRI and PET approaches, but I prefer the MRI because there are no injections. Any standard 3T (or even 1.5T) strength scanner should handle it. - Jarred Younger
Did you account for heart rate and age of the participants or their physical activity levels, hemoglobin or anemia? Of course if a subject's heart is beating faster, then more blood and, thus, more oxygen will be diffusing across the blood brain barrier throughout the brain (all else being equal).
Dyspnea, or shortness of breath, is common in Chronic Fatigue Syndrome. It might result from respiratory trauma, which might alter the breathing pattern permanently, leading to shallow breaths when the person is not consciously controlling their breathing.
How do you cure CFS
@@keylanoslokj1806by healing your liver
Hey don’t worry it’s not permanent. I’ve had this condition and I’ve recovered from CFS. Now I breathe normally again.
Read about methylene blue.
I have lomg COVID and i noticed whenever exposed to more air i feel better. Oxygen in blood drops when sleeping and no sleep apnea
That makes no sense. Are you not normally on the Earth, 100% fully exposed to air?
I had a second sleep study done after being diagnosed with narcolepsy and sleep apnea, and the neurologist said I had had a stroke at some point.
Thankyou lots of factors, causing or affecting diff pathways.
What about delivery of oxygen to
brain via haemaglobin, how does it change during the day, with exercise, with deep breathing, how is it linked to blood pressure or overall health ie cardio vascular health atheroscerlosus, what is causing low blood orifusion which factors poor breathing patterns over months years little aerobic exercise, low ferritin level etc etc, toxins what biochemical pathways?
These are great questions…must be from a doctor. Wish he had presented some treatment for this…
I think your questions are on a similar track to mine. Along with haemoglobin is it's capacity to deliver blood (bohr effect), the overall blood viscosity, and vascular constriction/relaxation.
Thank you for the information.
absolutely! This is why stellate ganglion block and HBOT improved cerebral blood flow and resolved a lot of cognitive issues and malaise for me and my ME/CFS. this makes complete sense for me.
I’ve been considering HBOT. How long did the therapeutic effects last for you? Or how often do you receive treatment?
What's the first thing you mention?
@@liliha986 i did one series of 20 one hour sessions over a month at 1,5 ata and at first i felt immediate but transient symptom relief from the added oxygen, then gradually i started feeling worse, until the end of the treatment where i felt like some symptoms had gotten worse, but it seemed as if it was just my immune system ramping up. i felt crappy for a month, then i had a couple of kambo sessions that gave relief for a couple days, then it disappeared. after that i gradually started to improve slightly, then during an LSD session there was some phase transition to a new stable state where i have been symptom free and able to move without PEM, for 13 weeks now!
@@daphne4983 it's a nerve block they put in your stellate ganglion, it inhibits the sympathetic nervous system and floods the brain with blood! it reduced sensory sensitivity and cognitive impairments and emotional flatness, it has also calmed down some immune responses and gave me my deep sleep back.
@@arasharfa that’s awesome!! It makes sense you felt worse first. Thanks for the info! I’m going to look into HBOT.
Is there contact information for you? I am a 57 year old female with diagnosed migraines. In May I woke in the night with severe head pain. I was screaming and running into walls. I was very dizzy and my toes went numb. Once the hospital controlled the pain, I realized that my short term memory was gone. I couldn't complete a sentence because I would forget what I was saying. After 3 days my memory started to get better. Then I had a repeat a week or so later. It has happened a few times since ,to a lesser degree. This is extremely scary. They released me from the hospital without knowing what was wrong. I have not fully recovered. I can't drive because I forgot where I am going. My blood pressure has been low the last 2 times 80/63.
Something is truly wrong but I don't have a doctor helping me. I did see a neurologist who ruled out MS. I was diagnosed with CF and fibromyalgia in 2005. I don't know what is happening, but I really need help and can't find anyone local.
I am in a similar situation, it is so frustrating. Good luck to you.
This sounds to me like thyroid issues.. I have low blood pressure and low blood sugar which makes me act really stupid from time to time
I will have my thyroid checked. Thank you!
Thank you for your amazing research! I'm not an expert but was thinking about reginal hypoxia (RH), leading to a range of major or minor changes in brain function. You mentioned tumor or trauma as causality, but what about "micro" strokes? Could they not also lead to RH and hence a decline, however minimal it may be, in brain function and hence cognitive changes. And then of course the consideration of successive micro strokes (months or years) leading to an increase in areas (same or different) of RH and hence decreased brain function over time, perhaps with very minor symptoms following each micro stroke. All in all, a progressive cognitive decline that's barely recognizable, if at all. Thoughts?
Best regards.
Definitely there could be a cumulative effect of repeated transient ischemic attacks. One problem with tracking the TIAs is the MRI-based T2* or DWI scan may reveal the TIA only if acquired directly after the event. Then they heal (structurally) and look normal, but could leave a pocket of inflammatory activity by activated microglia. The microglia activity doesnt show up on the clinical scans. So, this problem is probably being missed in most cases. Another issue I am looking at is enlarged perivascular spaces. The PVCs are generally considered to be benign, but I'm not sure. I believe we see more in those with chronic pain, fatigue, and cognitive dysfunction, but I have to do more work to determine that for sure. - Jarred Younger
@@youngerlab Thank you for your informative reply. I hope your research continues to yield insightful results. The work that you're doing is very important.
Your location is listed on YT as “BIRMINGHAM.” Just a suggestion: you might be at UAB (Alabama) or elsewhere including UK (Birmingham, UK). Etc. You are on a global platform. Your content is interesting. I’m not sure what else to make of it “yet,” but I wish to see more. (Cutting edge discussions, like these,)
Thanks for letting me know. When I choose the location for the video, it does distinguish between Birmingham in the U.S. and the U.K., but then the difference isn't noted when the video is posted. I'll see if I can force the extra info to appear next time. I'm in the newer Birmingham, not the original. - Jarred Younger
How much does this oxygen perfusion test cost without insurance as I’m from UK or s there anything similar in UK
It seems like some of the same downstream effects of reduced perfusion could also result from hypoxia caused by obstructive sleep apnea.
Absolutely. I wish more people with ME/CFS and FM could have a proper sleep study to rule out sleep apnea. Most individuals with it are undiagnosed. I did a video about a year ago on how people can test for sleep apnea if they are unable to get a proper study done. th-cam.com/video/GRquu4_Zzsk/w-d-xo.html - Many people would find significant symptom improvement by fixing a chronic hypoxic problem at night. Thanks for mentioning it. - Jarred Younger
@@youngerlab Note that ME patients can develop apnea during the course of the disease. Also diabetes and parkinsonism.
Hi I've had sleep apnea for the past 15yrs and been on cpap for that time first couple of months were brilliant thereafter knackered everyday after watching your vlogs my blood oxy levels are spiking up/down how can I resolve them?
Great information, Jarred. Thank you.
Sleep apnea causes a lot of brain issues too.
Yup! I would know..
Correct. But it affects a different area of the brain.
Thank you. 🙏
Could this be an effect rather than the cause of illness? Possibly via hypotension or depression?
Unrelated: Any update on dextro-naltrexone study? Research proposal written?
Looking for a good synthetic chemist still. Everyone is so busy since the lockdowns and the chemists have their hands full producing new compounds for researchers. I contacted two more possibilities last week and am exploring options with them. I found someone with a small bit of the compound, but it is for animal use only, so that doesn't help me. I'm still working on it! - Jarred Younger
This is why pulse oximetry needs An overhaul in emergency settings. I had severe neurological symptoms due to this and they were ignored due to pulse oximetry being fine. Also melatonin fixes it.
Melatonin fixed WHAT?
@@allinaday9882 low oxygen/bad circulation/hypoperfusion of tissues
@@hollywoodn_twhat dose worked for you?
@@hollywoodn_telaborate?
Very helpful.
Has anyone tried the Mendi meditation / neurofeedback headband? It works by measuring perfusion in the prefrontal cortex. Could neurofeedback training cause PEM in people with ME/CFS?
I tried it and it rewarded PEM-inducing excitation. it was very tiring and didn't cause any long term improvements.
Perhaps why a high VO2 max is associated with longevity?
Have you identified any testing methods that are in clinical use bearing pathognomonic results
ie specific for ME/CFS
I dread shotgun style medical testing because most doctors don't know that stress testing can destroy you for weeks and I'm still working fulltme
This is so interesting!!!
Thank you. My O2 says are always 98-100% on a pulse oximeter. Is this something that would not be captured in an 02 sats reading? I’ve always suspected low o2 to the brain to explain many of my symptoms but doctors all look at me like I’m crazy.
Not at all. Good blood oxygen saturation is not indicative of good perfusion.
@@rachellemurray2696 Do you know why that is?
@@rdklkje13 perfusion is how much blood is circulating, not how saturated with oxygen that blood is. it's two different things.
@@rdklkje13 one is oxygen in your blood, the other is where that blood is getting to. Probably impacted by inflammation, endothelial function/dysfunction, blood pressure, orthostatic tolerance. But probably best to leave explanation to the expert. I believe this is why stimulants help with my brain fog. It’s also why I treat myself with anything that may decrease inflammation (steroids, antihistamines, therapeutic apheresis, cryotherapy, anti-inflammatory diet etc) and increase perfusion (HBOT, compression, counter postures, recumbent exercise within energy envelope etc)
What about microplastic?
also, 'smart' tech and a world gone computerized which causes shallow breathing and breath holding
Would continuous wear of a surgical mask such as a 3M Aura 1870+ Flat Fold Particulate Respirator/Surgical Mask for prolonged periods say an eight or 12 hour shift lower brain oxygen levels? Do you know of any studies on this topic?
sure would, and part of the plandemic to reduce oxygen ....like the cell towers, and being addicted to smart tech, antisocial medial scrolling = breath holding, shallow breathing, and radiating.The masks were part of that. I was a nurse working pre and intra plandemic. When the masks went on, that is when I got very sick with mold toxicity and severe covid. I'm still damaged, but yes oxygenation is huge. And they are reducing it.
Thanks
You commented that you didn’t expect people to have specific areas with poor flow rates. I may have missed something - but suggest that the initial insult to the brain from (for example) an autoimmune response to a virus which has temporarily targeted a sub-population of brain cells - would result in concentrated damage to that area. It sounds a little like you are convincing yourself of the lack of need to have high-resolution investigation of specific brain area blood flow because of your current technology limitation. Beware of that thought process! Keep up the great work 😊👍
You're right - we can't discount reasonable possibilities. We are running the local analyses right now - it just takes longer to compute and interpret than the whole-brain numbers. It is possible that each individual has different local regions, so they wouldn't emerge in a group average. But if a region comes up significant in the patient group as whole, that would be very interesting. Thanks! - Jarred Younger
You are very aware!
Would an oxygen concentrator help with this issue?
more like hyperbaric 02 to help usher in the 02 to the cells
I'm curious to know if the techniques that you used for this study are only recently developed?
This particular sequence has been around for quite a while, since the 1980s or 1990s. It isn't one of my experimental scans. - Jarred Younger
What about someone sleeping in a car with the windows closed? Any idea about the possibility of hypoxia?
you won't get enough oxygen if you sleep that way
We find it stuffy if theres not enough oxygen, natural sense.
@@Paul-dorsetuk any evidence for this?
@@RagdollRocket The OSHA requirements have a number of references I think.