Massive New Study shows Niacin and NAD+ cause Heart Disease?? Is this true? [Study 282]
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Reference
[1] [Study 282] Ferrell M, Wang Z, Anderson JT, et al. A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk. Nat Med. 2024;30(2):424-434. doi:10.1038/s41591-023-02793-8
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#niacin #heartdiseaseawereness #heartdiseaseprevention
![Niacin (Vitamin B3): Flushing Away Heart Disease. [4 Studies]](http://i.ytimg.com/vi/N17cmKCVxcw/mqdefault.jpg)
No amendments.
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You got my attention. The niacin bottle is open and am waiting for the bad news .
Lousy study gives bad information.
Niacin has been useful and has several dozens of excellent studies about its usefulness.
Did the study confirm how much Niacin was taken in by people via cereals and all manner of foods with heavy sprinkles of niacin added. Nope.
They have no idea how much niacin people brought in from all combined sources. What else did people consume that could account for bad results.?
They don’t know.
Lousy research without proper data controls yields lousy result.
This study should have been looked at seriously before releasing it to be published.
Niacin is effective at raiding HDL and lowering LDL.
If there is not a control that tells how much niacin was actually consumed from other sources how would a person taking 2,000 mg actually know how much niacin actually entered their body?
Good grief.!!
What other controls were ignored?
Feels like something a company with a patented competitor to niacin would put out.
Official data shows that the US pays 17 times more for healthcare while the Chinese have a three year longer life expectancy.
US universities have a history of producing observational studies that always find that unpatentable health intervetions such as vitamins and red meat etc are dangerous.
Show me the incentive and I will show you the outcome..
Agree. Seems like the statin companies are hard at work nowadays to discredit niacin.
EXACTLY.
100%
No idea why this guy is even given it his time.
80% of research is bunk.
Nicotinamide and niacin Nicotine etc are covid preventing
Niacin’s biggest problem is that it’s cheap, off label and not profitable for drug companies. There’s some great long term studies on Niacin consumption be controls, so I did an eye roll at this study and headline.
Wait until the fab 4 unmentionables start being used by the average Joe to treat/prevent C.
Nobel prize winner Abrham Hoffer swore by it and lived into his 90"s.
@@bbybeatboxx Instant release, (Flush) not some adulterated Pharma version. They've killed more ppl than we will ever know.
@@bbybeatboxxAnecdotal evidence.
@@bbybeatboxx...and healed so many with truly "angry" health conditions! I take this with a kg of salt, not just one grain....😊
It would be interesting to know who paid for the study and the researchers' affiliations.
conflict of interest is always popping its head in these academic reports..but rarely reported publicly
Good thinking.
Amazing how complex nutrition science is. Imagine the everyday person working a job and raising kids also having to keep up with this stuff. I was completely lost. So I’ll take your word for it.
I am surprised that this channel does not have at least 1 million followers
Maybe because he hides stuff just for Patreon? It’s a turn off.
@@stargazerbird Off-topic, but IMO that's still better than hopping on the AG1 train.
@@stargazerbird it is still very very informative for any person interested in health related clinical studies.
Because this is BS. that is why.
I'm not.
Follow the money. Always. Always.
When I heard about this study, I couldn’t wait to nerd out to your interpretation. Thank you!
I watched full video and conclusion I ended up is - if you use niacin rectally there is nothing to worry about.
Excellent.
@@Physionic just joking mate. Your content is gold. Thanks for you effort
As am I. 😉
🤣🤣🤣🤣damnnn lucky me I read the answer 'cause I was going to......😅😅
Good. I've been taking niacin rectally for a long time. It stings, but it is worth it.
Great work. I’ve got a video on this same paper coming out in the next couple of days
Looking forward to it!
I kind of had a feeling Brad was watching. It's the studies.
Thank you Brad, because I know already that your evaluation will be slightly different to this guy, as Nic is missing some crucial understandings.
At least niacinamide is safe though@@Physionic
I can't find the video infortunately
Did they differentiate between Flush free and full flush Niacin? My understanding was that full flush is the most efficacious.
Physionic, so to us non-bio plebs can this be summarized as: Niacin could be harmful for those that have a certain gene mutation that make 4PY inflame arteries. But direct administration of Niacin study shows lower CVD risk (adjusted non-statin control). Meaning that there is more evidence that Niacin likely reduces MACE (unless maybe you have that gene mutation). Does the study link the mutation and can we be tested to see if we have it?
good synopsis and question. wondering the same
What's SNP? What's the name of the gene mutation please?
@@naguarachamo1SNPs are snippets these are gene mutations that prevent the usage of nutrients vitamins or cannot properly convert to a usable for that the body needs.. for example many people have the MTHFR gene mutation because of this one can use methylcobalabine a methyl type of vitamin B12 to by pass this mutation
I immediately spat out my niacin after reading this headline a week back.
Thanks for the info.
I am on my 2nd pack of niacin, take 500 mg post breakfast.
I spat out 25% of my Niacin so I'm in the clear statistically speaking
well, pharma can buy comments and the commenter, so no surprize
no surprises both are on sale!@@TrueBlackBird
@@ash9x9 I take niacin before going to sleep, when cholesterol production/the intestines are most active. (since 2016)
Thanks for addressing this. I commented on it on this site when it first came out. I have afib and certain excess B vitamins and glutamate can aggrevated the problem. I've been on the look-out and have followed the recent literature on this score.
Have you looked in ablation? I had one last year. Not pleasant but best choice I made. I had Afib which got worse as it does abd ended up permanently in afib and then got a flutter. Both issues fixed in a day case surgery. I no longer sweat a lot for feel queezy when I exercise. I year on with Jo issues and have lost weight. Good luck.
Wow thanks for this. This is great research. Just the type we need to solve the CVD problem. Every day we are getting closer and people like you are making it happen, Thanks.
Skip to 14:20 unless you want to hold your hand over a candle flame for kicks.
Can you do a follow up video? I have heard that niacin does raise hdl but that hdl is more atherogenic? Can it do that? Can it reduce the quality of HDL that is raised?
Interestingly, no one is researching something that has been causing all kinds of cardio issues in just the past 2 and a half years...
What do you mean?
@@dr.yannis.karrerhe’s talking bout the vax
@@dr.yannis.karrercovid vaccines
@@dr.yannis.karrer i hope you are joking......are you?
@@jajajajaja357 nope
I have been taking high level of Niacin (Life Extension Mix) for over 35 years. (I am 69 now), so I am defiantly a long-term test subject. Mo cardiovascular issues except aortic stenosis, which is most a known issue with my bi-valve aortic valve instead of the normal tr-valve.
Ive been watching my aortic size for a couple of yrs now, has I have a bi-valve also... I'm at 5.2 and they want to replace it and put in a synthetic... I'm only 55... My dad had it also and lived to 75, then the vid took him out... Has I'm a pure blood I think I'm gonna risk it, has that infusion would make any heart thing worse...
@@maw9916 I have a aortic dissection 9 years ago and currently the same as you and it stays that way every year, every MRI. From some research states they don't have enough information to make conclusions on another repair regardless of size. Most studies and patients this 5.0-5.5 size is for patients without a repair done. I feel great and each year I show my cardiologist better test results in BP, LDL, physique. So I can understand what you are going through. I'm only 44.
What is your dosage?
Do you get the flush each time you take it?
@@snakeone007 Everyone gets the flush. Start out small (50-100mg) and build up if you're going to take it. Even 100mg will give a flush to someone new to the experience.
There was a study, on Glisodin, Nad booster, in reversing Atherosclerosis. I can't remember how big the study was but. Obviously many things such as Aged Garlic extract Natokinase and Berberine have shown impressive results. It is unfortunate, they didn't try combining them. Tocotrienols, also had some studies, but not all positive results.
I don't get it.
How does niacin supposedly not impact cardiovascular risk when by taking niacin my cholesterol (total and LDL) dropped significantly?
Seems like niacin does impact CVD risk. Literally on my blood tests before and after using niacin - pretty significant lowering of total and LDL
check out the follow up video
There could be another explanation which is not popular, CVD and high LDL is just association not causation.
@@supernova1976which has been common knowledge to anyone paying attention for a very long time
That's because he's not Abram Hoffer, that publicity got him easy way.
@@TrueBlackBird what do you mean?
“We also recognize that clinically observational studies by design show only association and not causation; thus, there always exist a possibility of unmodeled confounding that may have impacted our results through factors that are not included in our models (for example, we have no information on dietary niacin intake).” NO NIACIN DATA!!!
Well, do you trust the observational studies that show how bad smoking is? You quote this as though there is something wrong with observational studies but there really isn't. They are a tool in a toolbox and should be treated as such.
Agree
@ We may have _slightly more_ observational studies on smoking than on Niacin...
@ Smoking as it is understood today, after the addition of toxic substances... Or in history, when smoking was applied and used as medicine?
It is well known that the group of B-vitamins work together in a complex. Nowhere do I read about any control of such vitamins and their ratio to each other. No data at all... Levels of vitamin D, C... Dito.
Not everyone is a cardiac patient. If you have CVD, you are looking for help after the fact. I look at Niacin as I do Vitamin C. Pellagra and Scurvy shows us just how important these two nutrients are.
They are important, if you do have pellagra or scurvy
Vitamin C is water solvable. If you take it as a supplement, you just piss it out and make a pharma guy richer.
He doesn't disagree with you. Try reading it again.Triggery.
Fifty years ago, a brewery added niacin to beer to reduce foam. Shortly later, lumber jacks started having heart trouble so the brewery stopped adding niacin. Strange this massive study cannot look back.
Can you provide a source for this information? I’ve tried finding this brewery and the story online but to no avail.
That was the added inorganic cobalt.
thank you, thank you! I immediately checked for the snp and fortunately I do not have it. I continue to take 500mg niacin daily to boost my nad+ via the Price-Handler pathway, niacin's peculiar effect of lowering lp(a) is ignored when one says "no positive effect
He means no positive effect in CV clinical events. Of course it has "good" effect on the usual lipid markers, which may not matter.
Do you dose 250 in morning and 250 in the evening?
@aham4340 If they don't matter why measure them? Also, this is in people who have already had cardiac events, which is a big confounding factor.
"No effect" on niacin means it is not statistically better than statins. Niacin was not compared to placebo, as then the pharmas would have no dog in the comparison.
@@h.sowandegray2913 500mg in the morning along with 600mg TMG, folate, methylB12 and taurine
Too cool to say the longer word scientists- great.Good video.
This made me want to run out and purchase Niacin supplements. I do the opposite of what the gov wants.
Niacin is the foundation for some of the most promising longevity drugs. But it’s cheap.
That's the hack
Could you please tell us about methylene Blue, thanks 🙏
What about Niacinamide being good for treating Arthritis (according to Dr Eric Berg).. any dangers from it?
What dose of niacin were given?
New adverse cases of cardiology across the entire spectrum both acute and chronic is linked to the mRNA needle.
Big pharma tried to blame erythritol on this topic too which is also a distraction tactic away from the real risk.
Good thing we have tons of antivaxers so we can compare vaccinated and non vaccinated groups and check the incidence of multiple illnesses.
You (antivaxers) are super quick to blame the spike of cardiovascular issues on the vaccines and completely forget about the virus itself as the culprit of that kind of damage.
Given all the randomized trials, we would not administer niacin to most patients receiving statin therapy. Exceptions to this general approach would include patients at extremely high cardiovascular risk such as homozygous or heterozygous familial hypercholesterolemia patients who are not at goal with maximum dosage statin plus ezetimibe or colesevelam, particularly if they have Lp(a) excess and a family history of early onset of atherosclerotic cardiovascular disease. Patients who are unable to take other lipid-lowering therapies may consider long-term niacin therapy if their LDL-C is significantly elevated and is lowered substantially by a trial of niacin treatment.
With FH & Lp(a) "blessed" by both parents who had heart disease... been on very high dose statins, got palpitations, beta blocker, Praluent and others & diet for 25 years. Nevertheless, got plaque. Never had > glucose or blood pressure problems, on the contrary a slightly low blood pressure. Changed radically in 2016, stopped taking medications due to serious side effects. Resolved remaining neurological complaints with B12 injections and others... All against the advice of the lipidspecialist.
Started with 100mg niacin, (dose increased up to 2000mg) vitamin D, K2, magnesium & Krilloil. The plaque disappeared. Also confirmed after six months, additional check via MRI scan with contrast fluid. Then the lipidspecialist exactly wanted to know what i was using... I pause the use of and lower the dose niacin and take Hawthorn to avoid straining the liver. It does not lower my numbers (LDL 9), but it does work in my case to prevent consequential diseases. Family members who choose medication instead of supplements, they all deal with unpleasant side effects and(!) already had events. I'm the one (stubborn) black sheep of the family, still alive & kicking, without any events.
Please... Stop thinking lowering numbers as a goal; It's all about balance/ ratio. The oldest people on earth appear to be people with higher cholesterol levels...
What happened to "Let food be your medicine and your medicine be food”..?
Thank you. Did you have a high Bilirubin number when you were taking a high dose of Niacin ?
Been waiting for this one.
Very interesting, thanks for doing the work so people like me can make better decisions based on science!
The NR and NMN pathways are different from Niacin. Would've liked a nod to the relevance and also Nicotinamide.
"However, Hazen pointed out that ingestion of excess amounts of niacin - or related compounds such as nicotinamide adenine dinucleotide, nicotinic acid, and nicotinamide riboside - have all been shown previously to increase the level of 4PY, as well as another breakdown product, 2PY.”
@@jackbuaer3828 I really want clarification on this also.
Curious why there have been no studies on the relationship between niacin and lowering of blood platelets? Known that blood platelets are responsible for blood clotting (a major factor in heart attacks and strokes), so since niacin reduces the number count of platelets why isn't that a benefit in lowering heart and stroke issues?
Great video. You really pulled multitudes of research information together well.
Immediate release vs sustained release. Huge difference.
That was no doubt intentional and intended to confound readers, I've seen many vitamin "studies" making seeming mistakes like this. Another popular "mistake" is to use trivial doses and conclude they have no effect.
@@headlibrarian1996 💯
Correct. Ive seen big pharm attack high dose vit c because "it couldn't be tolerated as a single dose to stomach". Total rigged game.
Statins are worth billions. Of course they will protect that industry. The number 1 statin shill on youtube..is dr brad.
Finished the video. Love how he builds up to his answer. New fanboy status continues.
Would this analysis apply to niacinamide and nicotinamide?
I have been taking Nicotinimide (flushing version) of Niacin for about two years now. I take low dosages (200mg - 300mg) per day because that's all I can stand. I will say that there are some people (like myself) are very sensitive to this stuff and itching and stinging skin can occur for days after ingestion. I recently decided to cut back to every other day and see if I can lessen the effects. I may just discontinue as I have very low risk factors for cardiovascular disease and the side effects are very annoying for me. If you have risk factors and can tolerate this stuff, then continue, but if you are sensitive, proceed with caution. It can be wicked stuff if you are sensitive.
cat·a·bol·ic
adjective
: marked by or promoting metabolic activity concerned with the breakdown of complex molecules (such as proteins or lipids) and the release of energy within the organism : relating to, characterized by, or stimulating catabolism
I realise many factors affect heart health, however, after doing my lay research into magnesium (including via your highly credible channel), I'm curious to know the correlation of magnesium deficiency with heart attacks? Magnesium is a prime cause of muscular fibrillation, and the heart is the most powerful muscle in our body with a significant requirement for magnesium.. so much so that magnesium is taken from the muscles at night for use in more important areas. Better that we wake up with a leg cramp than a heart attack, i say!
Can you please provide a review of real research into all the ways that magnesium improves cardiovascular health and in particular reduces the risk of heart attack?
Thank you 👍
Sir investigate the impact of excess of hydrogen peroxide in the body and how to boost catalase that goes down as we age
Some more flawed studies that once again show nothing. Why? Because there are too many variables that are not being tracked. The same goes for LDL and statins. Niacin is an essential vitamin, and NAD is essential for survival. Not enough of either or both will lead to pathology and eventually death. There's a lot we don't know, especially the diet, health, supplementary status and lifestyle of those involved. These questions will never be answered, because it's impossible to do human studies where everything is controlled. All this proves is that there is something that may be an association, but not causation - as we had with LDL and CVD. I will await your video on the effects on blood glucose control with interest.
Niacin is amongst my top 3 supplements, consuming around 500mg to 700mg per day.
great job!, thanks
ALL MY QUESTIONS
What type of Niacin was used
What dose
For how long
What type of patients were considered in this study
Did the patients have a pre-existing disease
Who funded the study?
Is it peer reviewed?
Is there a third party that has verified the findings?
What type of study was this?
Did they combine any pharmaceuticals with the vitamin?
Would really like to know what doses were used in the study and what type of niacin. In clinical practice, very high doses (in the gram range) have often been used in the past. I take about 120 mg a day and even though I'm a bit worried about the study, I'll keep taking it for now.
I take 500 mg daily after food & i Feel much better. I will not discontinue b/c after 6 months he will return with a video on how good is it!!
No niacin dosage reported/recorded in this data. Just Niacin metabolites. Multiple pathways to the metabolites: niacin, niacinamide, NAD+, NMN, etc.
Yep….the study has holes. They don’t site dose, nor source. Dr Ford Brewer asserts that it was from grain consumption. We know at this point that grain consumption is associated with increased inflammation.
I continue to use regular release niacin. It straightened out my lipid numbers when a statin alone could not.
Thank you Nic, i went over this study and , my conclusion was, i am not worried , I know It isn't a scientific conclusion, it is political 😂. Thank you again for confirming the science 🙏
13:49 This is what you came for.
Thank you
Is there any reference in this study to exactly how much niacin was consumed or taken? It just references "high levels of Niacin", but did they include dosages of supplements, dietary intake or just go by the blood tests?
Well diet is the number 1 cause so it's interesting for them to target Niacin and NAD, something a majority of the population does not take in supplement form. Makes me think these Niacin and NAD supplements might be way better for us than we intitially thought.
Niacin improves cholesterol and increases NAD and is cheap. So I could see why the NMN shareholders would want to banish it, which is difficult as it’s an essential B vitamin.
So should we start taking it?
What were the dosages of niacin looked at in this study?
So, if we're still worried (and I am), would getting our 4PY levels checked be a reasonable course of action?
I also want to know the answer to this question. I was thinking ApoB would be "the test" for CVD. Can 4PY be high and ApoB be normal?
Always the best content here!
I have familial hypercholesterolimea and high LpA. My mother and her two sisters all died of heart attacks at age 69. I am a 75 year old female… eat healthy foods (lots of veggies, sprouts, beans , low carb, very little sweets, etc.) . I also take many heart healthy supplements. Approx. one year ago my doctor finally convinced me to take a low dose statin. Within 4 months my cholesterol numbers had improved by 40 per cent. I decided to add high dose niacin and NAD to my supplement regimen thinking it would improve the numbers. Six months later a cholesterol retest showed a somewhat alarming rise in LDL, LpA and Triglycerides. Which all seems to be exactly what you are talking about!
What dose statin? Which one ? Thanks.
it would be great if you added time stamps
Thanks for getting this up! I was waiting for your take specifically on the latest study. As always, keep up the good work!
My brother-in-law sent me a link to a report on this study because I flaunted my niacin flush at him a couple weeks ago. I’m taking 100mg along with bergamot because someone touted their anecdotal evidence in a comment.
Recommendation 50mg split 2 3 times per day, not in lump.
Were these conclusions definitively reached from a statistical analysis of a double blind placebo-controlled study? Or were there an indeterminable amount of non-controlled confounding factors, one of which was niacin consumption, which produced the linkage?
Can someone give some clear answer what's would be best to taken as supplement because I'm getting really confused...and what dose
Astounding, you've restored my sleep rhythm Mr Physionic, thank you, for after 4 yrs of sluicing copious amounts of NR/NMN/TMG ( + copious other supps) into my Krebs cycle, I was sweating it somewhat over this study, though now I really must get onto what my polymorhisms actually are, anyone got any recommendations for complete genome sequencing ? I'm thinking of going through Nebula Genomics, are there better alternatives?
I wasn't sweating, I was flooding.
The AIM-HIGH trial of 3414 patients with established cardiovascular disease, low HDL-C, elevated triglycerides, and treated with a statin (mean LDL-C of 70 mg/dL) found no additional benefit to treatment with extended-release niacin .The study was stopped early for futility and because of a concern about increased numbers of ischemic strokes in patients treated with niacin, which were not significantly different from placebo after final adjudication. However, HDL-C levels in the "placebo" arm (which received 100 to 200 mg of niacin daily) increased more than expected, which may have reduced the ability of the trial to detect a real benefit with niacin therapy.
Of course they didn't, LDL and triglycerides are best controlled with instant-release niacin, and they certainly knew that, but wanted to imply to people not aware of the difference that instant-release is also bad.
Can't see any "linked video" as You stated @ 14:20-14:21! Has that been "sanctioned"?!😂😂❤🎉
Can you do a video on which vitamins actually are shown scientifically to help us ?
D3 seems to be one .
Thanks 👍
It's in the word - vitamin. All of them. Vital amin.
@@nenadcvele not sure...E has mixed reports
@@Nudnik1 It's not vital for our organism? I didn't hear about that.
@@Nudnik1 A and E are associated with increased total mortality. Have been for decades. Note that it's difficult to find fish oil pills (EPA, DHA) sold without added vitamin E. Cod liver oil has vitamin A, but that, I believe, is its natural state (not added).
@@Galahad54 thank you. I recall that..
My hart dr wants me to take niacin
So how long does it take to get heart disease. I’ve been taking 6,000 mg for 15 years. It lower my cholesterol to 159. It brought my liver enzymes back to normal. My blood pressure down to 110/70.
So when should I expect heart disease?
cardiovascular disease has been solved.
Arterial tissue fragility, local oxidation, and blood viscosity determine micro arterial damage. Small damage leads to small clots. They clot and then plaque with lp(a). Stressed arterial tissue calcifies. Bacterial invasion from periodontal bacteria in the bloodstream make it worse. Cholesterol in the plaque can form crystals which can make it worse. Insulin receptors in the plaque can make it worse if you have high insulin.
The solution for all of this is to have good oral hygiene(xylitol). Good gut integrity(bone broth). Good insulin levels(5:2 diet). Donate blood every few months. This lowers blood viscosity, lowers iron if it is in excess, and lowers other toxins in the blood. Every day take a few grams of vitamin c, ten grams of glycine, tocotrienol vitamin e, and maintain optimal copper levels. This creates strong arterial tissue(c,glycine, copper), low oxidative stress(c,e, and glycine(produces glutathione), and good blood viscosity(vitamin e). If plaque does develop it can be removed in about a month with EDTA, lysine, hydroxyproline, and beta cyclodextrin.
Not worried about Niacin.
Physionic - always the voice of stone, cold logic AND ultra-cool molecular biology pathways!
Most other sites disagree with you and the study.
Not sure about something. In the slide at 06:07 it says "ACMSD" gene and the slide at 11:38 reads "ACSMD". Are these different. I admit I got a little lost in the acronyms.
Misspelling. ACSMD is correct.
Thanks Nic
You only emphasise the high dosage negative effects. The second lowest showed a risk facto of less than 1, which, if I am reading your graph correctly means a decrease in risk AT THE APPROPRIATE DOSAGE. Pharmaceuticals have to be administered at the correct dose to keep the side effects to a minimum.
Niacin in organic Supplements is Good in moderation.
Excellent news.
I took nmn for 4 months, never had heart problems, now I am with pericarditis in hospital.and Troponin n my blood - and. Am weak -please be careful what you take- it can cost your life- love for all
Did you get the c-19 vax?
I have confirmed that all this is bad, just go visit your local Cardiologist and they will give you prescriptions drugs that will heal you lol
I just deleted a comment and am replacing it with a question. This study is about niacin, but the problematic metabolites (4PY and 2PY) are metabolites of NAD. NAD boosters like NMN and NR have become both controversial and polarizing. After watching a number of videos on this study, proponents of NMN and/or NR are defending them, and detractors of NMN and/or NR are disparaging them, even though there it yet to be data on the degree to which various doses of NMN and/or NR effect 2PY and 4PY levels. Most usage of NMN is to increase the relatively lower levels of NAD in older people, and in many cases, the levels are only partially restored to full youthful levels. So we're back to the question of whether NMN/NR (or even perhaps niacin at a reasonable dose) are beneficial for older people with age-related NAD decline, but perhaps not advisable for younger people with normal youthful levels of NAD.
What about my multivitamin that has niacin as niacinimide? This the same thing as that?
Sending us to an old video to guess which point you refer too is a bad idea.
What is the risk allele for the SNP? T or G? Thanks for your work.
Cover for the clot shot
How much is safe per day?
"The case against science is straightforward: much of the scientific literature, perhaps half, may simply be untrue." - Richard Horton, chief editor of "The Lancet" (2015)
90% of people over the age of 50 are choline deficient, cholesterol medications deplete choline and choline is also required for methylation especially in those with MTHFR negative polymorphism requires choline as it is the only reliable pathway for that. And those particles look like methyl groups to me....
Excellent.
An analogical issue with B12
The level of B12 in blood serum has a U-shaped profile.
Low levels has a hig mortality, but so has high mortality!
Does that mean high doses of B12 supplements are dangerous. Does a high dose of B12 increase mortality?
It seems that some serious diseases raises the level of B12.
And there's no indication of that supplementation with it does any harm.
This explains the U-shape as something else than caused by B12. There's a correlation though.
That's how easily this kind of mistake can be made.
Sometimes one has to do direct clinical trials to really find out!
Until that's done we don't know!
My automatic speculative suspicion is that a lot of the data has come from drug rehab data, but who knows. It’ll be interesting to see how this shakes out
I supplement b12 through energy drinks from a niche company. Would that explain my 2000 serum B12 levels if everything else is normal on the complete blood count?
Thanks for sharing this information!
Thank you for this well explained technical counter to the alarmist nature of the "study." Another interesting note -- none of the participants were supplementing with niacin. In fact, it was concluded by the author of the study that it was "dietary niacin" that was to blame for the rise in 2py/4py.
So for 3/4 of the people, niacin is OK. But what if you’re the other 1/4 of people in the high line? I’ve been taking NAD boosters for a year including niacin. If I’m being honest with myself, I’m feeling like I’ve aged faster and have been wondering what’s going on. Btw, love your channel. Just trying to figure out this puzzle.
The only worry is the worry for peoples pockets. Everything to be taken in moderation is always key
Does this mean it can be harmful to use niacinamide topically? And another quick question: can the topical use of niacinamide cause a nicotine overdose when combined with the use of nicotine?
Do the alleles matter at all on the gene? Just found it in my gene file but couldn't find anything about this
Complete aside: The small spin movement added to the diagrams is making me feel super woozy. But great video, and thanks.
Do the study also refer to consumption of NMN supplement?
Yes. I want to know the answer to this also. I'm not a biologist, (an engineer who hasn't had any biochem since freshman year in college) and don't know if "niacin" also implicates NMN.
Also, I thought ApoB was "the test" to verify CVD risk. Does this result mean we can have low ApoB and still have CVD risk?
So does this mean should i keep taking niacin or no 🙄???
?!?!?!??!?!?!?!?!?!??!??!?!?!
so a potential genetic link. thanks for doing this