I use it to stop blood clots forming, which given the new white clots which are mainly fibrin that form from either Covid or exposure to Covid vaccines, makes a fibrinolytic very attractive as a supplement in our post pandemic world. If you doubt the existence of white clots, you have not been following Danish or Japanese pathologists who are studying them.
I’ve been taking 8000 FU’s of Natto for approximately 1.5 years. I have cardiovascular disease and I’m checked regularly by my cardiologist. I do an ultrasound one year and a CT scan stress test the other year. According to my doctors, my blockage in one artery has diminished greatly, I went from an estimated 60% blockage to now a 30-40% blockage. I’ll never stop taking Natto.
Thanks...that's what I've been taking for two months or so. I'm not aware of any studies where people have taken over 6000fu, but everyone taking a higher potency seems to be benefiting.
I started taking Nattokinase (6KFU) about seven years ago. After taking it for 5 years I had a calcium score done. My cardiologist was adamant that supplements have no effect on atherosclerosis. He was shocked when my score went down! Yes it was mild, but going down is better than up. I've been taking 8KFU for the last 4 months and will bump that up to 10K.
@@hughb5092 As Vinsue has mentioned, calcium scores rarely, if ever go down. It's all a part of the natural aging process. So the fact that yours hasn't risen, and actually slightly decreased after 5 years passing, is a testament to the power of nattokinase. You might want to check out Lumbrokinase as well.... >>> ohbaby's substack
@@hughb5092I mean, I'm digging this unit. Nev'mind that this video never said what nattokinase does (open bean casing proteins (by straw microbiota) to make stringy goopy red beans? Hence natto?) or how the protein is preserved through digestion (not too normal?) Soon we'll be taking dark matter FushigiYuugium supplements that let you have a wish when you shout 'Kaiju!'
The amount of nattokinase they use makes a big difference, a lot of these studies under dose in the studies. I take 22,000f/u a day 11,000 morning and night. NK has a half life of about 12 hours, you have to keep your blood saturation up or the gains are very small. It’s like cleaning a piece of iron in the morning and not putting a rust inhibiter on it by night it’s rusted again. it has absolutely reduced my atherosclerosis. I have the images to prove it. After a year I included 1,500,000 units of lumbrokinase twice a week with 500mg of Berberine morning and night. For angina the best thing is Ouabain. Also you need to be on what I call the trifecta A,D3, K2-Mk7. You need at least 380mcg of K2-Mk7 to have any real effect.
@@CommodoreGrayum Try Augmented NAC instead. Denatures up to 100% of spike protein. Unless you've already recovered from Covid, I guess it may not be necessary.
Nattokinase is not only pseudo-science, it is fraud. How is it possible huge protein molecule to pass through the intestinal wall and to enter bloodstream? Only short proteins up to 10 amino acids can eventually pass through the guts. Nattokinase has >250 amino acids - who is saying that monster protein is passing freely through? Pure nonsense and fraud. Mainly fraud.
I had powdered Nattokinase a few years ago. 2 kilo bag. I overdosed sometimes. It was hard to measure. There were definitely side effects. It doesn't seem to be available in loose powdered form anymore.
I don’t go by grams with nattokinase or lumbrokinase I go by f/u. I had a thrombosis from my ankle to my hip, was in the hospital for four days with four insertion sites along the leg pumping atp into my leg. The hospital said I’d reached my maximum on this treatment even tho some of the thrombosis was still there I went home and started taking approximately 33,000f/u though out the day and night. The leg hurt so bad I want to vomit every time I got up to urinate. After day two the pain was receding fast so to get the pressure off the leg I started walking chest deep in my pool, and starting on lumbrokinase at the same time. I threw the blood thinners away. Nattokinase has an action that stops inflammation and pain very fast. In a week that leg was 99% normal, I went back for a scan a month later and they couldn’t see any signs of clots at all. They told me I’d probably be on blood thinners the rest of my life, HA. This a front line treatment for thrombosis and blood clots in Japan. I have taken this protocol for two years now and feel great. I’m 75. BTW I have a background in microbiology. I know how to read research it’s my hobby in my retirement years, I pay for and use Ai in my research to go thru hundreds of research papers ever year. I have developed a protocol for CVD and atherosclerosis that works I’m my own lab rat.
I've taken Nattokinase and Serrapeptase for over ten years. Not all the time but for a-period-of-time on and a-period-of-time off. I've seen results with both and I do recommend them for the slow healthy ways to reverse some conditions. For instance, my scars are gone. I say gone but the color of some spots where there was scar tissue is still a lighter tone but no bump where there used to be a bump scar tissue. Natural medicine should be included with all medical insurance. Rockefeller has had enough power over human body health. I had a good friend who was an MD and he used to laugh about using vitamins. He died about 7 or 8 years ago of cancer. Who knows, maybe if he had taken preventative supplements he might have never had cancer. I have taken Curcumin with Ginger daily for at least 15 years and have no health issues at 73. I also take no drugs, prescription or otherwise.
I always laugh at MDs who turn their nose up at vitamins. Linus Pauling was one of the greatest scientists of the 20th century and he saw the value in vitamins.
Here I am again, back in college while on my couch listening to my favorite professor. And yes your handsome face adorned with spectacles,( the symbol of an intellect that studies closely) is always a captivating sight, because seeing it always offers the promise of new understandings.
That bit about the ad!🤣🤣 I greatly appreciate your work. Yours is the ONLY channel where I watch EVERY video - often several times. Thank you for your work! ❤
I realize that the high dose natto atherosclerosis study lacked a control arm, but given that pre and post dosing arterial wall blockage measurements were used, it seems to me that each subject acted as their own control. A physical measurement is a much better assessment than a softer criteria like suffering fewer heart attacks because other factors come into play.
Plus that study was a follow up study by the authors. They did one earlier that was smaller, and had very similar, beneficial results on atherosclerosis and hyperlipidemia, just as the latter, much larger study did. And whenever you can duplicate outcomes, that is strong evidence the results were authentic... Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants (Aug. 2022) Clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidemia (July 2017)
Unfortunately the only outcome that matters to me is the health outcome ie fewer advers cv events and it cant just be assumed that the way natto reduces plaque size is beneficial eg it may destabilise plaques in the process and create more adverse cv events
@@georgecav That's a good point. But then doctors and hospitals wouldn't be using it for the past 10+ years to treat cardiovascular diseases in clinical settings. >>> ohbaby's substack
@@ohbaby-baby Normally I would not a priori be impressed by what conventional health uses in a non acute setting. If they got things right, I wouldnt have been health educating myself independently for all these years…. However as it is a complementary/alternative product that does offer weight to its efficacy. I haven’t heard anyone using it here in Australia so I am wondering who apart from possibly the Japanese use it in their conventional cv health care and also if there is good research connecting it to improved cvd outcomes. I am thinking of taking it but given there is a bit of an act of faith involved with benefits not easily measured esp in the short term I would like a bit more evidence. )
@@georgecav Read my substack article in my last post to see the evidence/studies. I also posted those two studies on atherosclerosis earlier. And if you didn't know, that is the number one predictor of heart disease. There is also the Rotterdam study that shows if you reduce arterial plague, you reduce cardiovascular death. This was a study on K2 (Mk-7). But still it shows, by reducing calcification (hardening of the arteries) you reduce CV mortality. >>> ohbaby's subsrack
Moved to Japan 7 years ago and eat it for breakfast every day, as do so many Japanese. I also take it in supplement form. Before beginning natto, my calcium score was 23.2 in my LAD. Now, its zero, even though my LDL is elevated! My Japanese doctor said, if he was deserted on an island, the most important thing he would want is his natto - it's that critical to your health! That's enough proof for me. I no longer listen to Western doctors who contradict the use of natto.
I started out with 2000 FU. I did well on that amount, so then increased to 4000 FU per day of the supplement. I've been taking that amount for years. Good for you for taking action to improve your score!
Since inflammation is the root cause in much of this, you may find this paper interesting: Serratiopeptidase Attenuates Lipopolysaccharide-Induced Vascular Inflammation by Inhibiting the Expression of Monocyte Chemoattractant Protein-1
@@Physionic😂 I had to comment on your reply. Seriously, I watch you because you resemble my younger brother who departed this world in 2009. So you make me smile because your sense of humor reminds me of him as well. ❤
@@PhysionicI'm an old man now, and you're a good looking lad. One day you will be old too, and you will look back on photos of yourself and appreciate how good looking you were.
I had a TIA seven years ago.My whole right side went numb. By the time we arrived to the ER, it resolved itself except for very minor numbness at the tips of two fingers. Two weeks ago, I had another incident with my left leg becoming half numb as well as a small area on my left side. It stayed with me for two days. I started nattokinase 4000 FU 2 times a day. Within one day, the slight numbness in my fingers all but disappeared, the numbness in my leg also started to lessen - now gone- with the small patch still there in the mornings. I am going to stick with it. I must take baby aspirin so limit the dosage. I believe it works for me.(Arthur Andrew Brand)
You can make natto cheaply in large batches and freeze it. Eating about 3.5 ounces daily with mustard (tastes a little better) and provides roughly 20,000 FU of nattokinase. I think it’s a little healthier to eat as a food source rather than as a supplement because it has protein, vitamins K2, minerals, probiotics , nutrient synergy, and fermentation benefits. I’ve been eating this daily for the last year for the following possible benefits: 1. **Cardiovascular Health**: Helps reduce blood pressure and dissolves blood clots. 2. **Bone Health**: Rich in vitamin K2, which supports bone density. 3. **Digestive Health**: Contains probiotics that improve gut health. 4. **Immune Support**: Enhances immune system function.
@@Mellon_Musk I throw all my healthy food into five vitamix blenders on Sunday and blend them right before consuming every morning. This is going to sound vile but oddly all the ingredients kind of cancel out how disgusting each one is 😂2 cups of white tea, 3 tablespoons lemon juice, 2 tablespoons apple cider vinegar, 3 ounces natto, 6 sweet Jared beets, 1/4 cup sauerkraut, 1/3 cup kefir, 1 teaspoon olive oil, 1 teaspoon black seed oil, 1 teaspoon cod liver oil, 1 tablespoon of sea moss, fermented papaya, 2 pickled garlic, 1/4 teaspoon kimchi, frozen berries, pineapple, arugula, dandelion, honey, Tumeric ginger shot, kale, frozen broccoli, carrots - been drinking this for over a year and it actually tastes surprisingly really good
I'm with you concerning the use of natto. Have been eating an ounce a day and my blood is thinner, meaning when I cut myself it takes a little bit longer to clot. The Japanese also discovered that eating Kiwi with natto helps with bone building.
@@Mellon_Musk Can't do much about the slime but the smell you can just pick premade natto that contains less ammonia. Personally I use Mizkan which is a reddish package, and innoculate batches of soybeans with it. You can check out natto dad's videos on how to make them and which brands to pick.
I can only attest to the benefits of Nattokinase anecdotally. One important thing to note is that Nattokinase is destroyed by stomach acid. I think that is the reason why higher doses are useful. At a high dose some smaller percentage will survive to make it to the bloodstream. I use Nattokinase in conjunction with Natto. The reason is that I will have to eat took much Natto to get the 12,000 fu I need. Natto at this dose will add to much calories to my diet and lead to weight gain. Natto has a slime matrix which preserves the nattokinase from stomach acid and survives it the passage intact. I mix 8000 fu nattokinase powder with 100 grams natto( probably aroung 1400fu/day). I make the natto myself to keep cost down. I can only say how Natto/ Nattokinase has helped me overcome many health problems. The list of benefits are much too long to enumerate here.
Nattokinase is not only pseudo-science, it is fraud. How is it possible huge protein molecule to pass through the intestinal wall and to enter bloodstream? Only short proteins up to 10 amino acids can eventually pass through the guts. Nattokinase has >250 amino acids - who is saying that monster protein is passing freely through? Pure nonsense and fraud. Mainly fraud.
@@thomasmuller1850 I couldn't find a reliable supplier. Careful there are a lot of fake nattokinase supplements. Beside Natto gives good microbiome bacteria...a probiotic.
the nattokinase I take (Nattovean from Arthur Andrews) says that since it is derived from a food source, it is naturally acid stable so it does not need an enteric coating to protect from stomach acid.
I love your posts! From dismantling and dissecting studies to exposing the TH-cam hacks. I even broke out my old college stat books and watched a few refresher stat vids so I could be mathematically abreast of your findings. So please continue to be that one positive outlier to the right and let the rest endlessly prove The Law of large numbers with their average (or below) work. Thank you! 👍👍👍
Nick fails to mention Nattokinase has been an official medicinal used in hospitals and clinical settings in Asia for over a decade. You would think that would be important to consider before summarizing it has little to no effect. >>> ohbaby's substack
The name nattokinase comes from the Japanese word nattōkin (納豆菌), which is the name for Bacillus subtilis var natto. Nattokinase is an enzyme found in the sticky part of natto, a traditional Japanese food made from fermented soybeans and Bacillus subtilis. In 1980, Japanese researcher Hiroyuki Sumi discovered that natto could dissolve artificial fibrin and extracted an enzyme from it that he named "nattokinase". As it is not a 'kinase', some pronounce it nuttOkines.
My Japanese American friends pronounce it like "gnatto" rhyme with CAT. The way Nick is saying it, wouldn't we translate that as "notto" ? Yeah, Nattokinase Gnat-o-kin-aze
My personal experience is getting a way lower blood pressure. Went from 145/90 to 115/75 in a month. The reason i started taking nattokinase was a discovery of plaques during a CRT scan. They aren't a risk factor yet, but i thought to try this. Will keep taking it for a total of two years and then take another CRT scan. Note: Dosage is low (4,000f/u a day), and i also cut back on sweets.
To answer your question: I believe there isn’t enough info to conclude Nattokinase is effective, but there is reason to test further at the higher dose, with well designed and controlled studies.
It is effective. It's an official medicine for over a decade in Asian hospitals along with Lumbrokinase. The west is far behind the times. Big Pharma can't have these cheap effective supplements wiping out their blood thinners and statins. Statins are their biggest seller by far... “Lumbrokinase is used as an oral supplement to support and maintain healthy cardiovascular function, and to treat cardiovascular diseases in clinical [practice] for more than 10 years." Lumbrokinase Protects Against Myocardial Ischemia-Reperfusion Injury - (nih.gov) (June 2018)
I've been on bo medicine for years. I started taking Nakk a few weeks ago. My BP is down to 117/75. I haven't taken my BP medicine in a month. It works.
I follow a doctor whose name escapes me right now, but he used to be the head of prevention medicine at John Hopkins hospital. He takes nattokinase and includes fermented foods in his lifestyle. ❤
After using it along with a 90% plant based diet... I'm happily relieved to report that over a period of 9 months my blood pressure decreased from 165/120 to 138/89 !!!! I hadn't checked my BP in 6 months and didn't expect any changes so I was very thrilled with the results... I even changed the batteries and checked again. Same result. I do exercise and take potassium, magnesium, vitamin K2, D3, zinc, lumbrokinaise as well. Pitched amlodipine and losartan 18 months ago despite the warnings from family and the medical community.
My sister & I both used natto & nattokinase to rid the body of long Covid. Nutrient form, not all manufactures are reputable. If you have a Japanese market near by, highly recommend eating a pack & using nutrient for 2nd dose. Ex natto AM, capsule PM
What about the calories? Even though something is “good” for you doenst mean you can eat large amounts. Olive oil is also good for you but is also high in calories so it’s a problem. It’s about finding the sweet spot and this is why supplementation is crucial. We simply can’t eat each and every food that is “good” for us everyday or we would be consuming too many calories, whether they’re “good” or not. Then weight becomes an issue.
Awesome video! I loved your creatine breakdown for kidney function. Could you maybe do a video on ashwaghanda and liver damage? Many people like Peter attia take it but seems there are studies proving it can lead to liver failure
About the dose. The information from one you tube is ... In the high dose study, they also had data on lower dose. There were ~60 participants take 3,600 fu and result is plaque reduction 4%. The high dose of ~11,000 fu(~1,000 participants has plaque reduction 22%.
Just became a follower….. I like your short and packed videos I can’t watch all the research that takes two hours to explain I’m not looking to become a scientist lol …. Keep up the good work brother
The company Arthur Andrew’s medical has a product with both Nattokinase and serapeptase It’s branded as Neprinol It helped me tremendously with fibrin deposits from injury scars I was considering surgery then found it
Interesting, thanks for the tip. I take both nattokinase and serrapeptase and recently had a heart CT scan show zero calcification. Along with that I take D3, K2 and berberine. All good.
@@tracymullane8818 this is all great to read Keep going I had my issue with fibrin gone a long time ago but still take the combo as a preventative Maintenance Thanks for replying I take the things that you take as well and I also take all I of the DoNotAge supplements
It all comes down to belief. Since there's no negative effects from dosing Nattokinase, a person can run the experiment on themselves, especially if they're hypertensive. If you can afford coffee at Starbucks and go for drinks on the weekend, you can more than afford the supplement.
ang, I do agree with you on the point of being sensitive to our own bodies. That said, I also feel a certain allegiance to the scientific method. If someone takes a new supplement and experiences a positive effect, they may choose to believe that it's was the new supplement, and they may be correct but... they also could be incorrect. So we definitely ought to pay attention to our bodies, but most people aren't sophisticated enough to identify and track the many variables -- confounders -- that can contribute to the outcome. Be well. Cheers!
Good one as always. Consider looking into serrapeptase, which has similar claims made about it (and often you can find nattokinase + serrapeptase combined in a supplement).
I was just diagnose with that and it is in both the aorta and the large artery going down to the kidneys. I just order two bottles here in the Philippines so hope it is good quality and real. Wish me luck.
The effect may be small but if it actually *reverses* plaque wouldn't that be huge? AFAIK habits and other medicines can only slow/prevent further progression. To me this would also suggest that you continue lifestyle and statin and also potentially supplement with nattokinase, as the mechanisms are synergistic?
Thanks for another great video - as a layperson can you explain why a study wouldn’t have a control group, this seems to come up quite a lot and the people doing these studies are obviously highly educated so feel like they must have a reason?
There is a suggestion in a web page by the Japan NattoKinase Association, titled "What is Nattokinase?" that states it is best to take nattokinase supplements shortly before bedtime. It seems that YT will not allow direct posting of the link.
Both my mother and myself had headaches for months above the ears and other problems. Once we took Nattokinase it first got worse for 2 days and then suddenly disappeared. When we take 2000 FU of Nattokinase things just feel a little better. At 4000 FU things start to move in some part of the body somewhere and it usually hurts. This can take 2-3 days before things are suddenly much better. Like a finger that had little feeling since an accident 15 years ago now is recovering quickly to normal levels. Or my mother's cold feet that hurt for a while when being "worked on" by Nattokinase and now are normally warm. The stuff is absolutely crazy.
Whenever you improve your cardiovascular system, which is the entire point of this enzyme, the benefits can be very wide ranging. I have had improvements with my psoriasis, arthritis, blood oxygen, etc.. With better circulation, more nutrients, more oxygen, reach more cells in the body and will have systemic effects.
@@williamlee6079 2000 FU once or twice per day. I would not go beyond that myself but everybody is different. I once tried 6000 FU and next morning had tons of blood stains on my sheets, because of my Psoriasis.
Ahhh you were given the good brain! Good research I reached this same conclusion years ago, but still the testing goes on… so I say it is my awesome working placebo treatment. The power of positive thinking stuff…😮
The Japanese ladies (admittedly 3rd generation) pronounced it "nah-toe" in the Japanese food store in California. It came in a styrofoam container as a pile of soybeans inoculated with natto fungi (?). It's a sticky mass like thickened saliva, not particularly appealing, and probably an acquired taste. Thank you for the informative video. I had no idea anyone had done studies on it.
Great video! Thanks for all the hard work. I developed a natto habit while living in Japan for two years. I still eat natto 6 days a week. Love it! Unfortunately it only contains 1400-2000FU per serving. As much as I enjoy it eating 5.5 servings per day is not an option lol! Too bad we can’t get an unbiased study at 11k fu a day.
There is a relationship between Natto, Nattokinase and Vitamin K2. Natto is the source of both kinase and the strongest source by far, of k2. K2 in itself is also known to help with cardiovascular health and slowing down plaque buildup. I tend to believe that it works.
Thanks for the video, Nicolas. (I did not skip the ads.) Have you any information on lumbrokinase? Specifically, the product Boluoke from the company Canada RNA? There's an article titled "Lumbrokinase - An Enzyme for More Than Just Circulatory Health" by Martin Kwok that gives some information on the product, along with the Canada RNA website itself.
Natto is popular with people suffering from LongCovid. It seems to help reduce "microclots" and leads to better outcomes a large cohort. Similar to nicotine patches... It helps 2/3rds of those that try Natto. Timing is important because it needs to be taken on an empty stomach. Some can stand 10k FUs...but I can only take 2000.
The FLCCC ( you can Google them yourself) medical group was onto this for Long Covid early on. They also recommend it as a method to help clear the body of the Spike Protein that is In that extremely questionable vaccine🤨
I had sensitive stomach after taking 2000 Fu 2 to 3 times daily before foods for 3 months. That was 2 years ago. I will try again but will take olive/ sesame/ castor 10 minutes after taking it to protect my stomach. How in your case and you cud only take 2000 FU ?
@@williamlee6079 Natto will affect all kinds of proteins... so it is best to take it when you first get up and to wait an hour before eating anything. I do not know what effect oils would have on absorption or effectiveness.
I take TRT (Testosterone Replacement Therapy), which tends to increase my hematocrit levels to the low end of the high range, usually between 50 and 54. Initially, I tried reducing this by undergoing phlebotomy or donating blood, but that left me feeling tired and unable to engage in vigorous activities, which didn't suit my daily exercise routine. Then, I discovered the clot-busting properties of Nattakinase. I began taking two capsules daily of 'Doctor's Best Natto-Serra 2000 FU' about four years ago. The Serra part is Serrateri which protects the enzyme from inactivation by stomach acid. At my next blood test, my hematocrit level had dropped to 44, and it has remained at that level ever since.
Been taking 12000FU for 18 months .. no reduction in FIBRINOGEN ANTIGEN or LP-PLA2 .. although mine were both extremely low. I’m now taking 8000FU … just as an anti coagulant. Safer than aspirin. Ps: excellent insiders today .. SO happy to see it come on my podcast feed.
I've been an infusion patient for several years as well as having decades of experience using supplements of all types.....I'm skeptical of anything I ingest these days, proven or not. I also monitor my BP daily and have blood draws/labs at least once a month. I decided to try this supplement for a couple weeks before my infusion/labs. I had several very experienced staff try and draw blood with 14 pokes in all. I am usually a 1 poke guy and good to go. Also, I noticed BP numbers dropping 10 points. I have no other explanation as to what happened other than attributing it to this supplement. I can't tell if my experience was a good thing or a bad thing, but with blood draws being critical in my life, I stopped taking this.
They kept trying inside the elbows? I've had troublesome veins there all my life so I tell the phlebotomist at each draw and they use the back of the hand instead, and it's always one stick, good draw. Try it, a lot less painful in the long run.
I'm confused. Why would eating nattokinase or other whole proteins (e.g. bGH from milk) allow them to get into the bloodstream rather than be broken down and inactivated in the digestive system? Is this relying on a leaky digestive system, and if so how consistent would that be in various people.
Consuming Natto the food has helped immensely with my Long Covid symptoms. I reckon Natto is better than the supplement because it also has Vitamin K2 which apparently pulls calcium from the bloodstream and dumps it in the bones, thereby reducing calcification of the arteries and strengthening the bones. This is an overlooked aspect of the cardiovascular benefit of Natto. When studying Natto and foods in general, I wish the scientists could look at the comprehensive benefit of a food, rather than being myopic and using a supplement in studies. The listed studies don't show the full value of Natto.
Since natto is a daily staple of the Japanese diet I would like to know the following: What is the preponderance of atherosclerosis among the Japanese, what concentration of nattokinase is consumed in daily Japanese food? Finally, how best could someone living in the US obtain natto for consumption in food?
Arent there marked differences in effects of nattokinase vs serapeptase vs lumbrokinase? I think one is more preventative and one other leans more towards reversal.
I used this recently, resulting in the resolution of fibrin which had attached to my BD Power Port. However, it might have also dissolved the fibrin in the fibrocartilage in my arthritic knee. After discontinuing lumbrokinase and adding glucosamine I can walk without pain again. Very little information is available about lumbrokinase. I did ask the FDA to look into it further.
@@paigevanpelt1967the 3 “ase’s” : natto, Serra, and lumbro all do different things. I wish they’d just do one video telling us how to take all 3, the correct dosages and timing. It’s really hard to watch every clinical study and understand it all, plus very time consuming.
One thing I don’t understand is how can Nattokinase have a blood thinning effect? Isn’t it packed with vitamin k-1? I use Edoxaban 60 mg but want to quit as it only helps with the anti coagulation part and not the plaque. Want to start with nattokinase instead which actually goes to the root cause of why I need Edoxaban, instead of taking Edoxaban. How can Natto have that blood thinning effect if it contains K-1?
Nattokinase contains vitamin K2 MK7 which is supposed to help shuttle calcium out of the blood vessels and into the bones. Calcium does tend to accumulate in plaques as well, right? So might that also be a MOA of how it works to reduce artherosclerosis?
One thing I don't understand, if Nattokinase is a protein, wouldn't the stomach acid denature it and the proteases break it down before it can be absorbed in the gut? Wouldn't the studies just be showing the benefits of the amino acids that make up Nattokinase?
You are correct. What the video doesn't tell and comments section does not discuss is need to take NK on an empty stomach with plenty of water to dilute stomach acids... in hopes the enzyme is not fully digested.
My own Anecdotal Experience with CAC score results done by a radiologist who had no access to my medical chart (I paid outside of my health care at Kaiser). June 7, 2017 CAC 107 Cholesterol 216 August 5, 2019 CAC 193 Cholesterol 117 Had taken atorvastatin and K2, D3, magnesium for two years. Possibly had been taking bromelain July 2, 2021 CAC 164 Cholesterol 249 Had stopped the atorvastatin but kept taking K2, D3, magnesium for two years. July 10, 2023 CAC 292 Cholesterol 218 Unfortunately I took a tablespoon of lecithin every day for two years to lower cholesterol. I found out later that lecithin may lower your cholesterol but it increases you TMAO which causes plaque. Did not take bromelain. I now take K2, D3, magnesium, and bromelain. My cholesterol at the blood bank in May 2024 was 197. K2, D3, and magnesium without anything to lower cholesterol DID decrease by CAC score from 193 to 164 in two years. It could be the bromelain. But I'm sticking with the K2. K2 MK-7 100 Mcg
Don't worry about cholesterol being high. It's essential for life. If you want to lower cholesterol, then eat 12 oreo cookies a day for 2 weeks... yep it's absurd thing to do but 2x effective as a statin. But equally pointless. For your lipid panel focus on having high HDL and low Triglycerides. LDL Cholesterol ( ldl is just a transporter) only becomes an issue if you are eating sugars, refined carbs or vegetable oils.. all of which cause inflammation. Im no dr but there are plenty here on TH-cam explaining the plaque formation mechanism and blaming LDL is like blaming the firemen for the fire.. because they are always there. Statins are poison and serve no purpose but generate billions every year
@@niceadz6164 I've been a 100% vegetarian for 53 years (as has my husband who has a CAC score of 6). I make 98% of our meals using whole grains, beans, lentils, etc. I am 75 but I've never been to the ER, never been hospitalized, never had surgery, never broke a bone. I've been my own guinea pig to find out what stops plaque build up and what increases it. The plaque I now have is not causing any physical problems. I believe that for me it is that my body doesn't make K2 from all the greens I eat as it does for others. (I take probiotics.) I think it is inherited as both parents had heart issues in their 80s. But they weren't vegetarian.
Natto has a very low bioavailability hence much larger doses need to be studied to see if it has strong effect on reducing lipid formation, healing the glycocalyx and lowering BP.
For people who just eat natto every day, it would be interesting to know how many FUs are in a 40g portion of store bought natto. In Japan natto is considered a health food, but doctors usually say no more than 3 packs per day, or about 120g of natto.
My concern is that natokinse is a blood thinner. That means you must be careful about dosage. If you take too much you can have trouble with blood clotting. Dental work, small cuts can become dangerous.0
Hey @Physionic, could you consider making a video about AC-11, a cats claw extract claimed to have longevity benefits? Im not sure if it’s necessarily good. Sometimes, don’t we need to expunge older things to keep things refreshed? Apparently, AC-11 reduces transcription degradation/error.
Serious question here. Do YT content providers get paid more if those of us watching watch the full ad instead of skipping ahead? Occasionally (i.e. 10% of the time) an ad appears that is interesting to me, and if I liked the YT channel like this one, I would consider watching it to completion.
I wonder if Serrapeptase added to natto would have a synergistic effect in reducing atherosclerotic risk? Serrapeptase is an enzyme derived from the silkworm and has been used in traditional medicine for various purposes. It is also believed to have fibrinolytic properties, potentially aiding in the breakdown of blood clots.
At 6:19 all 3 show a decrease after 8 weeks so why the ( no effect ) I would say those are biased and anyone taking Nattokinase are taking it for a lot longer than 2 months including myself. I got rid of a clot on my right eye optic nerve in 7 days that caused total blindness. Before that I went 3 1/2 years taking statins and apixaban while the mini-strokes got worse, with gradual vision loss. I was taking 12,000fu/once a day to dissolve the clot. At 8:00 minutes the high dose is 10,800fu and I take 4 to 8,000fu as a low dose
A better question about nattokinase might be," does lifelong consumption, as per Okinawan/ Japanese population, even at lower dose , account for the vaunted longer lifespan," aka blue zone" effect"? In other words, can it hurt?
One would have to track the biological differences between said Japanese and whomever is the person asking the question. People become accustomed to a certain way of eating, and their gut microbiome adapts accordingly. Given how important our microbiome is in how we make use of food, this is just one of several important confounders to account for. So, you're right, and there's even more to it than that. Cheers!
The dosing of Natto is as important as when it is taken and the overall diet of the person in question. It is recommended that Natto be taken 20-30 (or longer) minutes before meals or 2-3 hours after. When taken with food it becomes a digestive supplement and most likely would diminish its heart and blood circulation benefits. A person diet rich in sugars and carbohydrates would definitely impact the benefits of taking Natto as this diet triggers artery inflammation. In order to really fully understand the benefits of natto a control group would need to follow the same diets, Natto dosing amounts and timing of the dosing relative to meals.
I generally enjoy your understanding of the scientific literature. I have learned a thing or two, but your conclusions/impressions here on Nattokinase are dead wrong on any metric. Nick, your impression of it having mild to no effect, and that other supplements might be better, is obviously not true. Because doctors wouldn't be using it in hospitals and clinical settings as an official medicinal, for over a decade. Perhaps next, you will like to go over studies on some other time tested medicines, shown effective in clinical use? This is what kills me with these vids. This kid is a good researcher, but does not use all the evidence. He thinks all there is,.... is these studies. When in Asia, they use it regularly in hospitals instead of the standard blood thinners that can cause bleeds. Lumbrokinase is another proteolytic enzyme like Nattokinase also used in clinical settings. Lumbrokinase is used by some doctors to treat Lyme disease. It has the power to break down the biofilm of bacteria that causes Lyme disease. "Nattokinase increases the natural ability of the body to degrade the blood clots in different ways and confer many advantages such as oral administration, efficacy, cost effective, long lasting effects, stability in the gastrointestinal tract, as well as its potential to increase the ability of body to produce plasmin and urokinase. It works by directly degrading the fibrin and plasmin substrate, transforms pro-urokinase into uPA, hydrolyses PAI-1 and enhance the level of tPA, which facilitate fibrinolytic activity. Furthermore, both in vivo and in vitro toxicology experiments have provided strong evidence about the safety of nattokinase for human oral consumption, as until now, there is no toxicity detected upon its usage. Nattokinase..... has been extensively studied in Korea, Japan and China. Lumbrokinase exists as a complex of six serine protease isoforms. Each isoform has different molecular weights with a variety in fibrinolytic activity. It has a dual mechanism in clot degradation: acts on fibrin directly and activates plasminogen and converts it into plasmin, which subsequently induce plasmin-based clot dissolution." Role of Fibrinolytic Enzymes in Anti-Thrombosis Therapy - (nih.gov) (May 2021) “Lumbrokinase is used as an oral supplement to support and maintain healthy cardiovascular function, and to treat cardiovascular diseases in clinical [practice] for more than 10 years." Lumbrokinase Protects Against Myocardial Ischemia-Reperfusion Injury - (nih.gov) (June 2018) As mentioned in the study, it is used extensively in Asia. And you might think the US has the market on health care, but you would be sadly mistaken according to any statistics. There is much more evidence, but this is getting long. I just want to add that the study he highlighted, using a high dose of nattokinase that he questions,.. is a follow up study by the authors. They did one earlier that was smaller, and had very similar, beneficial results on atherosclerosis and hyperlipidemia, just as the latter, much larger study did. And whenever you can duplicate outcomes, that is strong evidence the results were authentic... Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants (Aug. 2022) Clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidemia (July 2017) You may ask why is the west slow on the uptake? Big Pharma can't have these cheap, safe, effective supplements wiping out their blood thinners and statins. Statins are by far, their biggest seller. >>> ohbaby's substack
Definitely dosing, and duration too. Over a period of a year - how about 5 years of that dosing? The dosing is pretty high for effective arterial clearing and people should take that with caution as it is a blood thinner. Don't take too high of doses and don't take with other blood thinners. I don't think it's a strong blood thinner, but at high doses it likely is. I think a big part is having the blood "non sticky" for a long period, and the existing sticky slowly dissolves out. Another big one is omegas, oc. Getting flaxseed oil or hempseed oil in your diet..., or just hte seeds themselves. oc, omegas can be blood thinners too, especially fish oil (not sure of the others), so be careful with combining omegas with nattokinase (especially if in high doses). Oh, and getting the toxins out - and exercise - get your body looking for food - it will find some in your arteries. And Chanca Piedra - but not on same day. It's another blood thinner... Pomegranates have something that reduces plaque. And staying adequate in B vitamins
Some people take it because it's supposed to dissolve the spike protein from a totally necessary, and absolutely safe and effective, medical intervention that people were coerced into having.
The enzymatic activity of Nattokinase is indicated by FU which stands for Fibrin Degradation Unit. FDU was shortened to FU probably by someone who is not aware of American English idioms.
Very much enjoy your channel, thanks for the content. Any thoughts on the claim that natty-k is good for reversing the effects of/flushing the spike protein from the old vaxy vax?
I can say taking clopidrel plus ASA plus two NK I was finding a lot of bruises. Cut back to one capsule and significantly less bruises. Cut ASA and bruises stopped.
My experience with taking nattokinase (10,000 FU) is it lowers my heart rate about 5-10 beats/minute during exercise. I monitor my heart rate during HIIT exercises. I have to exert myself more to get my heart rate to 90% of max when I am taking nattokinase.
@@POVgames Personally, I don't think it is a good thing for HIIT. But if I are trying to burn a few more calories I can work out longer/harder and burn maybe 10% more calories.
With the pandemic, a lot of people were checking their blood oxygen saturation with an oximeter. I have COPD, so I was always checking it. Mine stood at 94 to 96. Deep breaths I could reach 97. But after taking these enzymes, Nattokinase, Lumbrokinase, I'm up to 97 regularly and have reached 99 for the first time ever with large inhales. So, your heart rate dropping makes a lot sense,...since blood oxygen levels have improved and the heart doesn't have to work as hard.
I took it once for the anticoagulant abilities but having natural low blood pressure it was not good. Maybe the dosage was too high. Maybe I will try Natto the food from Japan 🇯🇵🗾 before totally thinking it's not for me.
Great work. It all comes down to any possible side effects and cost. Are there negative side effects? If not and you have atherosclerosis that current medicine is clueless on, why not give it a try? High dose seemed to lower my BP about 8-10 points. If I'm around in a couple years to remeasure my CAC and IMT, will decide then.
Maybe someone can help me with this. Taking NK helped me reverse angina symptoms within days. I also experienced many other positive noticeable effects. Sadly, I also started developing facial acne from it. I know most say that their skin imoroves while taking it, but I am apparently in the fraction of a percent of people who experience this. I can't understand why. Does anyone have an explanation?
Try a different more expensive- better (?) brand. There may be some other ingredient that is causing you a reaction. Maybe its a one time short lived thing as perhaps NK is having some cleansing action in your colon. Who knows? Are you still taking it? Did acne subside?
Unless they put the people with the higher doses on major diets with large amounts of weight loss, then it sure sounds like tripling the doses is what would have made the big difference. Any way that you look at it, they had very sizable improvements. There has to be something that caused that to happen. It might have been something else, but my money is on the nattokinase.
FWIW: high Serrapeptase use was a miracle for my sinus issues, but made my knuckle problems and bone spurs much worse. (This also happened to a friend using it.) A hand specialist said that scars help keep the joints sealed, and I imagine for all its drawback, the fibrin of the internal scars has benefits for some conditions.
After oral ingestion, does nattokinase remain intact in our gastrointestinal tract? Is it absorbed intact in our intestinal tract into our bloodstream? Is it regarded as a foreign protein by our body? Any antibody produced against it?
Did the "large dose" natto group take it as one bolus/day or divided? I've been taking 24000FU/day but divided into 3 doses. Also taking 200 mcg of MK-7 and 45 mg of MK-4. And CIMT about 9 months after 1st one was noticeably improved.
Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants (Aug. 2022) >>> ohbaby's substack
6000 doesn't do nothing. the successful study used 10800 FU. and I am using even much more combined with lumbrokinase and serrapeptase. too low doses are a joke.
No Amendments, currently.
(But I probably still messed up the pronunciation)
Nah toe.
Naw tow.
Please do one video that is just a stand up science comedy routine. You underestimate your comedic chops.
Really mess up the verbal police and call it NANO kin-a-see😜
I use it to stop blood clots forming, which given the new white clots which are mainly fibrin that form from either Covid or exposure to Covid vaccines, makes a fibrinolytic very attractive as a supplement in our post pandemic world. If you doubt the existence of white clots, you have not been following Danish or Japanese pathologists who are studying them.
@@mballer Naht awe.
I’ve been taking 8000 FU’s of Natto for approximately 1.5 years. I have cardiovascular disease and I’m checked regularly by my cardiologist. I do an ultrasound one year and a CT scan stress test the other year. According to my doctors, my blockage in one artery has diminished greatly, I went from an estimated 60% blockage to now a 30-40% blockage. I’ll never stop taking Natto.
Would you name the product you take for Natto?
@@BushyIV Zenavea nattokinase 2000FU from Amazon. Which I could provide a picture. Black. Bottle
Thanks...that's what I've been taking for two months or so. I'm not aware of any studies where people have taken over 6000fu, but everyone taking a higher potency seems to be benefiting.
Did your cardiologist approve of this supplement for you?
Got rid of my cervical cyst, and helped my client who had a 40% blocked artery, great to see people healing themselves naturally.
WICH DOSE DID U TAKE
@@cheesemaker7270 10.000 👌
I started taking Nattokinase (6KFU) about seven years ago. After taking it for 5 years I had a calcium score done. My cardiologist was adamant that supplements have no effect on atherosclerosis. He was shocked when my score went down! Yes it was mild, but going down is better than up. I've been taking 8KFU for the last 4 months and will bump that up to 10K.
I have not seen a cac go down?? Which company do u order your supplements?
Dr's Best 2000FU ...My score had a modest reduction, which as my Cardiologist had mentioned that at the least, I had stabilized the plaques.
@@hughb5092 ty!!
@@hughb5092 As Vinsue has mentioned, calcium scores rarely, if ever go down. It's all a part of the natural aging process. So the fact that yours hasn't risen, and actually slightly decreased after 5 years passing, is a testament to the power of nattokinase. You might want to check out Lumbrokinase as well....
>>> ohbaby's substack
@@hughb5092I mean, I'm digging this unit. Nev'mind that this video never said what nattokinase does (open bean casing proteins (by straw microbiota) to make stringy goopy red beans? Hence natto?) or how the protein is preserved through digestion (not too normal?) Soon we'll be taking dark matter FushigiYuugium supplements that let you have a wish when you shout 'Kaiju!'
Today I learned that an FU is an actual unit of measurement.
🤣
hhhhhhhhhhhhhh
Fecal Units
I measure people with 2
Yo Japan Supplements Industry, fix us up! FU? Pay me!
The amount of nattokinase they use makes a big difference, a lot of these studies under dose in the studies. I take 22,000f/u a day 11,000 morning and night. NK has a half life of about 12 hours, you have to keep your blood saturation up or the gains are very small. It’s like cleaning a piece of iron in the morning and not putting a rust inhibiter on it by night it’s rusted again. it has absolutely reduced my atherosclerosis. I have the images to prove it. After a year I included 1,500,000 units of lumbrokinase twice a week with 500mg of Berberine morning and night. For angina the best thing is Ouabain. Also you need to be on what I call the trifecta A,D3, K2-Mk7. You need at least 380mcg of K2-Mk7 to have any real effect.
@@CommodoreGrayum Try Augmented NAC instead. Denatures up to 100% of spike protein. Unless you've already recovered from Covid, I guess it may not be necessary.
Nattokinase is not only pseudo-science, it is fraud. How is it possible huge protein molecule to pass through the intestinal wall and to enter bloodstream? Only short proteins up to 10 amino acids can eventually pass through the guts. Nattokinase has >250 amino acids - who is saying that monster protein is passing freely through? Pure nonsense and fraud. Mainly fraud.
I had powdered Nattokinase a few years ago. 2 kilo bag. I overdosed sometimes. It was hard to measure. There were definitely side effects. It doesn't seem to be available in loose powdered form anymore.
I don’t go by grams with nattokinase or lumbrokinase I go by f/u. I had a thrombosis from my ankle to my hip, was in the hospital for four days with four insertion sites along the leg pumping atp into my leg. The hospital said I’d reached my maximum on this treatment even tho some of the thrombosis was still there I went home and started taking approximately 33,000f/u though out the day and night. The leg hurt so bad I want to vomit every time I got up to urinate. After day two the pain was receding fast so to get the pressure off the leg I started walking chest deep in my pool, and starting on lumbrokinase at the same time. I threw the blood thinners away. Nattokinase has an action that stops inflammation and pain very fast. In a week that leg was 99% normal, I went back for a scan a month later and they couldn’t see any signs of clots at all. They told me I’d probably be on blood thinners the rest of my life, HA. This a front line treatment for thrombosis and blood clots in Japan. I have taken this protocol for two years now and feel great. I’m 75. BTW I have a background in microbiology. I know how to read research it’s my hobby in my retirement years, I pay for and use Ai in my research to go thru hundreds of research papers ever year. I have developed a protocol for CVD and atherosclerosis that works I’m my own lab rat.
I have never had any side effects. After my leg returned to health I cut my dosage back to my heart health protocol.
I've taken Nattokinase and Serrapeptase for over ten years. Not all the time but for a-period-of-time on and a-period-of-time off. I've seen results with both and I do recommend them for the slow healthy ways to reverse some conditions. For instance, my scars are gone. I say gone but the color of some spots where there was scar tissue is still a lighter tone but no bump where there used to be a bump scar tissue. Natural medicine should be included with all medical insurance. Rockefeller has had enough power over human body health. I had a good friend who was an MD and he used to laugh about using vitamins. He died about 7 or 8 years ago of cancer. Who knows, maybe if he had taken preventative supplements he might have never had cancer. I have taken Curcumin with Ginger daily for at least 15 years and have no health issues at 73. I also take no drugs, prescription or otherwise.
It seems you would have loved to revive your MD friend just to be able to tell him 11000xFUs!
I always laugh at MDs who turn their nose up at vitamins. Linus Pauling was one of the greatest scientists of the 20th century and he saw the value in vitamins.
Here I am again, back in college while on my couch listening to my favorite professor. And yes your handsome face adorned with spectacles,( the symbol of an intellect that studies closely) is always a captivating sight, because seeing it always offers the promise of new understandings.
That bit about the ad!🤣🤣
I greatly appreciate your work. Yours is the ONLY channel where I watch EVERY video - often several times. Thank you for your work! ❤
Thanks, Alice :) missed you at Office Hours! Hope you’re well :)
@@Physionic Thank you! Yeah, my day got away from me. My loss!
Well stated.
I realize that the high dose natto atherosclerosis study lacked a control arm, but given that pre and post dosing arterial wall blockage measurements were used, it seems to me that each subject acted as their own control. A physical measurement is a much better assessment than a softer criteria like suffering fewer heart attacks because other factors come into play.
Plus that study was a follow up study by the authors. They did one earlier that was smaller, and had very similar, beneficial results on atherosclerosis and hyperlipidemia, just as the latter, much larger study did. And whenever you can duplicate outcomes, that is strong evidence the results were authentic...
Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants (Aug. 2022)
Clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidemia (July 2017)
Unfortunately the only outcome that matters to me is the health outcome ie fewer advers cv events and it cant just be assumed that the way natto reduces plaque size is beneficial eg it may destabilise plaques in the process and create more adverse cv events
@@georgecav That's a good point. But then doctors and hospitals wouldn't be using it for the past 10+ years to treat cardiovascular diseases in clinical settings.
>>> ohbaby's substack
@@ohbaby-baby Normally I would not a priori be impressed by what conventional health uses in a non acute setting. If they got things right, I wouldnt have been health educating myself independently for all these years…. However as it is a complementary/alternative product that does offer weight to its efficacy.
I haven’t heard anyone using it here in Australia so I am wondering who apart from possibly the Japanese use it in their conventional cv health care and also if there is good research connecting it to improved cvd outcomes. I am thinking of taking it but given there is a bit of an act of faith involved with benefits not easily measured esp in the short term I would like a bit more evidence. )
@@georgecav Read my substack article in my last post to see the evidence/studies. I also posted those two studies on atherosclerosis earlier. And if you didn't know, that is the number one predictor of heart disease.
There is also the Rotterdam study that shows if you reduce arterial plague, you reduce cardiovascular death. This was a study on K2 (Mk-7). But still it shows, by reducing calcification (hardening of the arteries) you reduce CV mortality.
>>> ohbaby's subsrack
Moved to Japan 7 years ago and eat it for breakfast every day, as do so many Japanese. I also take it in supplement form. Before beginning natto, my calcium score was 23.2 in my LAD. Now, its zero, even though my LDL is elevated! My Japanese doctor said, if he was deserted on an island, the most important thing he would want is his natto - it's that critical to your health! That's enough proof for me. I no longer listen to Western doctors who contradict the use of natto.
Same/except moving to Japan…😊
@@davidhuber7166 You'll love it! 😀
i have a score of 45 on my LAD. Im 47 and i dont want this to get worst, Just place an order... How much did you take?
I started out with 2000 FU. I did well on that amount, so then increased to 4000 FU per day of the supplement. I've been taking that amount for years. Good for you for taking action to improve your score!
Since inflammation is the root cause in much of this, you may find this paper interesting: Serratiopeptidase Attenuates Lipopolysaccharide-Induced Vascular Inflammation by Inhibiting the Expression of Monocyte Chemoattractant Protein-1
@@donalkinsella4380 Google Serrapeptase and WebMD. See how much of a scam it is.
Chronic Inflammation is the devil for cardiovascular diseases.
Wow great thank you lad 🙏🏼
@@danielsaragih See also specialized pro resolving mediators at the enn eye ache
Came for dashing good looks. Stayed for the cruel mistress that is science
You have a low bar for what you consider “dashing good looks” 😂
@@Physionic😂 I had to comment on your reply. Seriously, I watch you because you resemble my younger brother who departed this world in 2009. So you make me smile because your sense of humor reminds me of him as well. ❤
@@Physionic Hey buddy, I beg to differ😁 you're a little stud muffin! 🙃
@@PhysionicI'm an old man now, and you're a good looking lad. One day you will be old too, and you will look back on photos of yourself and appreciate how good looking you were.
Nah. You're cute. And you know it. @@Physionic
Your breakdown of this subject was exceptional! I've watched quite a few videos on TH-cam about this, and none were explained as well as yours.
Thanks! I actually felt I could have done a bit better, but I'm always aiming to improve
I had a TIA seven years ago.My whole right side went numb. By the time we arrived to the ER, it resolved itself except for very minor numbness at the tips of two fingers. Two weeks ago, I had another incident with my left leg becoming half numb as well as a small area on my left side. It stayed with me for two days.
I started nattokinase 4000 FU 2 times a day. Within one day, the slight numbness in my fingers all but disappeared, the numbness in my leg also started to lessen - now gone- with the small patch still there in the mornings. I am going to stick with it. I must take baby aspirin so limit the dosage. I believe it works for me.(Arthur Andrew Brand)
You can make natto cheaply in large batches and freeze it. Eating about 3.5 ounces daily with mustard (tastes a little better) and provides roughly 20,000 FU of nattokinase. I think it’s a little healthier to eat as a food source rather than as a supplement because it has protein, vitamins K2, minerals, probiotics , nutrient synergy, and fermentation benefits. I’ve been eating this daily for the last year for the following possible benefits:
1. **Cardiovascular Health**: Helps reduce blood pressure and dissolves blood clots.
2. **Bone Health**: Rich in vitamin K2, which supports bone density.
3. **Digestive Health**: Contains probiotics that improve gut health.
4. **Immune Support**: Enhances immune system function.
But how to skip the smell n the slime
@@Mellon_Musk I throw all my healthy food into five vitamix blenders on Sunday and blend them right before consuming every morning. This is going to sound vile but oddly all the ingredients kind of cancel out how disgusting each one is 😂2 cups of white tea, 3 tablespoons lemon juice, 2 tablespoons apple cider vinegar, 3 ounces natto, 6 sweet Jared beets, 1/4 cup sauerkraut, 1/3 cup kefir, 1 teaspoon olive oil, 1 teaspoon black seed oil, 1 teaspoon cod liver oil, 1 tablespoon of sea moss, fermented papaya, 2 pickled garlic, 1/4 teaspoon kimchi, frozen berries, pineapple, arugula, dandelion, honey, Tumeric ginger shot, kale, frozen broccoli, carrots - been drinking this for over a year and it actually tastes surprisingly really good
I'm with you concerning the use of natto. Have been eating an ounce a day and my blood is thinner, meaning when I cut myself it takes a little bit longer to clot. The Japanese also discovered that eating Kiwi with natto helps with bone building.
@@Mellon_Musk Can't do much about the slime but the smell you can just pick premade natto that contains less ammonia. Personally I use Mizkan which is a reddish package, and innoculate batches of soybeans with it. You can check out natto dad's videos on how to make them and which brands to pick.
Won't the freezing kill the probiotics?
I can only attest to the benefits of Nattokinase anecdotally. One important thing to note is that Nattokinase is destroyed by stomach acid. I think that is the reason why higher doses are useful. At a high dose some smaller percentage will survive to make it to the bloodstream. I use Nattokinase in conjunction with Natto. The reason is that I will have to eat took much Natto to get the 12,000 fu I need. Natto at this dose will add to much calories to my diet and lead to weight gain. Natto has a slime matrix which preserves the nattokinase from stomach acid and survives it the passage intact. I mix 8000 fu nattokinase powder with 100 grams natto( probably aroung 1400fu/day). I make the natto myself to keep cost down. I can only say how Natto/ Nattokinase has helped me overcome many health problems. The list of benefits are much too long to enumerate here.
Natto should be in enteric coated capsules so it survives into the lower intestine
Nattokinase is not only pseudo-science, it is fraud. How is it possible huge protein molecule to pass through the intestinal wall and to enter bloodstream? Only short proteins up to 10 amino acids can eventually pass through the guts. Nattokinase has >250 amino acids - who is saying that monster protein is passing freely through? Pure nonsense and fraud. Mainly fraud.
@@thomasmuller1850 I couldn't find a reliable supplier. Careful there are a lot of fake nattokinase supplements. Beside Natto gives good microbiome bacteria...a probiotic.
@@bigstrongguy91 Taking it in the morning before meals helps.
the nattokinase I take (Nattovean from Arthur Andrews) says that since it is derived from a food source, it is naturally acid stable so it does not need an enteric coating to protect from stomach acid.
I love your posts! From dismantling and dissecting studies to exposing the TH-cam hacks. I even broke out my old college stat books and watched a few refresher stat vids so I could be mathematically abreast of your findings. So please continue to be that one positive outlier to the right and let the rest endlessly prove The Law of large numbers with their average (or below) work. Thank you! 👍👍👍
Nick fails to mention Nattokinase has been an official medicinal used in hospitals and clinical settings in Asia for over a decade. You would think that would be important to consider before summarizing it has little to no effect.
>>> ohbaby's substack
The name nattokinase comes from the Japanese word nattōkin (納豆菌), which is the name for Bacillus subtilis var natto. Nattokinase is an enzyme found in the sticky part of natto, a traditional Japanese food made from fermented soybeans and Bacillus subtilis. In 1980, Japanese researcher Hiroyuki Sumi discovered that natto could dissolve artificial fibrin and extracted an enzyme from it that he named "nattokinase".
As it is not a 'kinase', some pronounce it nuttOkines.
Thank you
My Japanese American friends pronounce it like "gnatto" rhyme with CAT.
The way Nick is saying it, wouldn't we translate that as "notto" ? Yeah,
Nattokinase
Gnat-o-kin-aze
My personal experience is getting a way lower blood pressure. Went from 145/90 to 115/75 in a month. The reason i started taking nattokinase was a discovery of plaques during a CRT scan. They aren't a risk factor yet, but i thought to try this. Will keep taking it for a total of two years and then take another CRT scan. Note: Dosage is low (4,000f/u a day), and i also cut back on sweets.
Any progress ?
Let us know after 2 years please?
To answer your question: I believe there isn’t enough info to conclude Nattokinase is effective, but there is reason to test further at the higher dose, with well designed and controlled studies.
It could, since Natto lowers BP..
only people on blood thinners, need to be careful on nattokinase/natto
It is effective. It's an official medicine for over a decade in Asian hospitals along with Lumbrokinase. The west is far behind the times. Big Pharma can't have these cheap effective supplements wiping out their blood thinners and statins. Statins are their biggest seller by far...
“Lumbrokinase is used as an oral supplement to support and maintain healthy cardiovascular function, and to treat cardiovascular diseases in clinical [practice] for more than 10 years." Lumbrokinase Protects Against Myocardial Ischemia-Reperfusion Injury - (nih.gov) (June 2018)
I've been on bo medicine for years. I started taking Nakk a few weeks ago. My BP is down to 117/75. I haven't taken my BP medicine in a month. It works.
I follow a doctor whose name escapes me right now, but he used to be the head of prevention medicine at John Hopkins hospital.
He takes nattokinase and includes fermented foods in his lifestyle. ❤
2:05 👌👌👌
3:30 Fibrin
4:40 Studies
5:35 Lipoprotein
8:55 Atherosclerosis
9:45 Argument 2
10:55 Summary
After using it along with a 90% plant based diet... I'm happily relieved to report that over a period of 9 months my blood pressure decreased from 165/120 to 138/89 !!!!
I hadn't checked my BP in 6 months and didn't expect any changes so I was very thrilled with the results... I even changed the batteries and checked again. Same result.
I do exercise and take potassium, magnesium, vitamin K2, D3, zinc, lumbrokinaise as well.
Pitched amlodipine and losartan 18 months ago despite the warnings from family and the medical community.
Congrats! can you share what dose you used?
My sister & I both used natto & nattokinase to rid the body of long Covid. Nutrient form, not all manufactures are reputable. If you have a Japanese market near by, highly recommend eating a pack & using nutrient for 2nd dose. Ex natto AM, capsule PM
What about the calories? Even though something is “good” for you doenst mean you can eat large amounts. Olive oil is also good for you but is also high in calories so it’s a problem. It’s about finding the sweet spot and this is why supplementation is crucial. We simply can’t eat each and every food that is “good” for us everyday or we would be consuming too many calories, whether they’re “good” or not. Then weight becomes an issue.
You had it right before. Enunciation on the TOE sound. I’ve been making my own Natto for years. Good stuff. ❤️
Awesome video! I loved your creatine breakdown for kidney function. Could you maybe do a video on ashwaghanda and liver damage? Many people like Peter attia take it but seems there are studies proving it can lead to liver failure
Natto does taste delicious once you acquire a taste for it.
I love the smell of my nattokinase capsules, so I can imagine, it is good
Loved the "i'm taken" line. I subscribed b/c of it.
Its clear drs should be pushing Natto over statins.
I love how you say the FU portion with a straight face.😁
About the dose.
The information from one you tube is ...
In the high dose study, they also had data on lower dose. There were ~60 participants take 3,600 fu and result is plaque reduction 4%. The high dose of ~11,000 fu(~1,000 participants has plaque reduction 22%.
Just became a follower…..
I like your short and packed videos I can’t watch all the research that takes two hours to explain I’m not looking to become a scientist lol ….
Keep up the good work brother
Totally fair :)
Welcome!
@@Physionic could you pls make a video on the effects of long term use of supplements esp Vit D versus natural sun exposure
Thank you for making science great again!
The company Arthur Andrew’s medical has a product with both Nattokinase and serapeptase
It’s branded as Neprinol
It helped me tremendously with fibrin deposits from injury scars
I was considering surgery then found it
Interesting, thanks for the tip. I take both nattokinase and serrapeptase and recently had a heart CT scan show zero calcification.
Along with that I take D3, K2 and berberine. All good.
@@tracymullane8818 this is all great to read
Keep going
I had my issue with fibrin gone a long time ago but still take the combo as a preventative
Maintenance
Thanks for replying
I take the things that you take as well and I also take all I of the DoNotAge supplements
@@tracymullane8818- how much nattokinase & serrapeptase do you take?
@@tracymullane8818 could you please give us the dosage of Nattokinase and Serrapetase you are taking?
Care to expand on that?
It all comes down to belief. Since there's no negative effects from dosing Nattokinase, a person can run the experiment on themselves, especially if they're hypertensive. If you can afford coffee at Starbucks and go for drinks on the weekend, you can more than afford the supplement.
Some experienced for example colon bleeding from too much though (200mg).
ang, I do agree with you on the point of being sensitive to our own bodies. That said, I also feel a certain allegiance to the scientific method. If someone takes a new supplement and experiences a positive effect, they may choose to believe that it's was the new supplement, and they may be correct but... they also could be incorrect. So we definitely ought to pay attention to our bodies, but most people aren't sophisticated enough to identify and track the many variables -- confounders -- that can contribute to the outcome. Be well. Cheers!
Damn dog, you broke his heart.
Now he's howling at the neighbors.
Good one as always. Consider looking into serrapeptase, which has similar claims made about it (and often you can find nattokinase + serrapeptase combined in a supplement).
I was just diagnose with that and it is in both the aorta and the large artery going down to the kidneys. I just order two bottles here in the Philippines so hope it is good quality and real. Wish me luck.
The effect may be small but if it actually *reverses* plaque wouldn't that be huge? AFAIK habits and other medicines can only slow/prevent further progression. To me this would also suggest that you continue lifestyle and statin and also potentially supplement with nattokinase, as the mechanisms are synergistic?
Thanks for another great video - as a layperson can you explain why a study wouldn’t have a control group, this seems to come up quite a lot and the people doing these studies are obviously highly educated so feel like they must have a reason?
A smart move 😂 great thx 🙏
I saw a study in Poland that it works but only a dose like 12000.
You pronounced it correctly! I wish there was a study done on Nattokinase and serrapeptase.
Thanks for what you do.
There is a suggestion in a web page by the Japan NattoKinase Association, titled "What is Nattokinase?" that states it is best to take nattokinase supplements shortly before bedtime.
It seems that YT will not allow direct posting of the link.
Both my mother and myself had headaches for months above the ears and other problems. Once we took Nattokinase it first got worse for 2 days and then suddenly disappeared. When we take 2000 FU of Nattokinase things just feel a little better. At 4000 FU things start to move in some part of the body somewhere and it usually hurts. This can take 2-3 days before things are suddenly much better. Like a finger that had little feeling since an accident 15 years ago now is recovering quickly to normal levels. Or my mother's cold feet that hurt for a while when being "worked on" by Nattokinase and now are normally warm. The stuff is absolutely crazy.
Whenever you improve your cardiovascular system, which is the entire point of this enzyme, the benefits can be very wide ranging. I have had improvements with my psoriasis, arthritis, blood oxygen, etc.. With better circulation, more nutrients, more oxygen, reach more cells in the body and will have systemic effects.
I noticed my dad’s cold hands becoming warm, too, after a while of supplementing with 2000FU almost daily.
Is it 4000 FU once or 3 times daily ?
Tks
Is it 4000 FU once or 3 times daily ?
Tks
@@williamlee6079 2000 FU once or twice per day. I would not go beyond that myself but everybody is different. I once tried 6000 FU and next morning had tons of blood stains on my sheets, because of my Psoriasis.
Ahhh you were given the good brain! Good research I reached this same conclusion years ago, but still the testing goes on… so I say it is my awesome working placebo treatment. The power of positive thinking stuff…😮
The Japanese ladies (admittedly 3rd generation) pronounced it "nah-toe" in the Japanese food store in California. It came in a styrofoam container as a pile of soybeans inoculated with natto fungi (?). It's a sticky mass like thickened saliva, not particularly appealing, and probably an acquired taste. Thank you for the informative video. I had no idea anyone had done studies on it.
The bacteria that ferments natto is called Bacillus natto
Great video! Thanks for all the hard work. I developed a natto habit while living in Japan for two years.
I still eat natto 6 days a week. Love it! Unfortunately it only contains 1400-2000FU per serving.
As much as I enjoy it eating 5.5 servings per day is not an option lol!
Too bad we can’t get an unbiased study at 11k fu a day.
There is a relationship between Natto, Nattokinase and Vitamin K2. Natto is the source of both kinase and the strongest source by far, of k2. K2 in itself is also known to help with cardiovascular health and slowing down plaque buildup. I tend to believe that it works.
Thanks for the video, Nicolas. (I did not skip the ads.) Have you any information on lumbrokinase? Specifically, the product Boluoke from the company Canada RNA? There's an article titled "Lumbrokinase - An Enzyme for More Than Just Circulatory Health" by Martin Kwok that gives some information on the product, along with the Canada RNA website itself.
Natto is popular with people suffering from LongCovid. It seems to help reduce "microclots" and leads to better outcomes a large cohort. Similar to nicotine patches... It helps 2/3rds of those that try Natto.
Timing is important because it needs to be taken on an empty stomach. Some can stand 10k FUs...but I can only take 2000.
The FLCCC ( you can Google them yourself) medical group was onto this for Long Covid early on. They also recommend it as a method to help clear the body of the Spike Protein that is In that extremely questionable vaccine🤨
I had sensitive stomach after taking 2000 Fu 2 to 3 times daily before foods for 3 months. That was 2 years ago. I will try again but will take olive/ sesame/ castor 10 minutes after taking it to protect my stomach.
How in your case and you cud only take 2000 FU ?
@@williamlee6079 Natto will affect all kinds of proteins... so it is best to take it when you first get up and to wait an hour before eating anything. I do not know what effect oils would have on absorption or effectiveness.
@@Unitedstatesian ok tks, i will try with the oil to find out, perhaps to post an update in a few months time
That’s because long covid is actually a response to the vax. So, anything to reduce clots is a good idea.
For those that can't stomach straight natto.
1 banana (or 1/2 an avocado)
Coconut water.
1 packet of natto (frozen)
Make a smoothie.
I take TRT (Testosterone Replacement Therapy), which tends to increase my hematocrit levels to the low end of the high range, usually between 50 and 54. Initially, I tried reducing this by undergoing phlebotomy or donating blood, but that left me feeling tired and unable to engage in vigorous activities, which didn't suit my daily exercise routine. Then, I discovered the clot-busting properties of Nattakinase. I began taking two capsules daily of 'Doctor's Best Natto-Serra 2000 FU' about four years ago. The Serra part is Serrateri which protects the enzyme from inactivation by stomach acid. At my next blood test, my hematocrit level had dropped to 44, and it has remained at that level ever since.
Been taking 12000FU for 18 months .. no reduction in FIBRINOGEN ANTIGEN or LP-PLA2 .. although mine were both extremely low. I’m now taking 8000FU … just as an anti coagulant. Safer than aspirin.
Ps: excellent insiders today .. SO happy to see it come on my podcast feed.
Thanks, JP. Glad to hear it.
I've been an infusion patient for several years as well as having decades of experience using supplements of all types.....I'm skeptical of anything I ingest these days, proven or not. I also monitor my BP daily and have blood draws/labs at least once a month. I decided to try this supplement for a couple weeks before my infusion/labs. I had several very experienced staff try and draw blood with 14 pokes in all. I am usually a 1 poke guy and good to go. Also, I noticed BP numbers dropping 10 points. I have no other explanation as to what happened other than attributing it to this supplement. I can't tell if my experience was a good thing or a bad thing, but with blood draws being critical in my life, I stopped taking this.
They kept trying inside the elbows?
I've had troublesome veins there all my life so I tell the phlebotomist at each draw and they use the back of the hand instead, and it's always one stick, good draw.
Try it, a lot less painful in the long run.
I'm confused. Why would eating nattokinase or other whole proteins (e.g. bGH from milk) allow them to get into the bloodstream rather than be broken down and inactivated in the digestive system? Is this relying on a leaky digestive system, and if so how consistent would that be in various people.
Consuming Natto the food has helped immensely with my Long Covid symptoms. I reckon Natto is better than the supplement because it also has Vitamin K2 which apparently pulls calcium from the bloodstream and dumps it in the bones, thereby reducing calcification of the arteries and strengthening the bones. This is an overlooked aspect of the cardiovascular benefit of Natto. When studying Natto and foods in general, I wish the scientists could look at the comprehensive benefit of a food, rather than being myopic and using a supplement in studies. The listed studies don't show the full value of Natto.
There's no reversing death.
Just eat natural foods and don't sit for long like my Grammy and you can live to 101 like her.
No reversing death but stopping and reversing aging.
Too late for me, I am already 98% dead.
Since natto is a daily staple of the Japanese diet I would like to know the following: What is the preponderance of atherosclerosis among the Japanese, what concentration of nattokinase is consumed in daily Japanese food? Finally, how best could someone living in the US obtain natto for consumption in food?
Asian store
Arent there marked differences in effects of nattokinase vs serapeptase vs lumbrokinase? I think one is more preventative and one other leans more towards reversal.
I like to hear more about Lumbrokinase, which is supposedly a more powerful version with a slightly different mechanism.
I used this recently, resulting in the resolution of fibrin which had attached to my BD Power Port. However, it might have also dissolved the fibrin in the fibrocartilage in my arthritic knee. After discontinuing lumbrokinase and adding glucosamine I can walk without pain again.
Very little information is available about lumbrokinase. I did ask the FDA to look into it further.
@@paigevanpelt1967the 3 “ase’s” : natto, Serra, and lumbro all do different things. I wish they’d just do one video telling us how to take all 3, the correct dosages and timing. It’s really hard to watch every clinical study and understand it all, plus very time consuming.
Hello, how long and in which dosis you have take it?@@paigevanpelt1967
One thing I don’t understand is how can Nattokinase have a blood thinning effect? Isn’t it packed with vitamin k-1? I use Edoxaban 60 mg but want to quit as it only helps with the anti coagulation part and not the plaque. Want to start with nattokinase instead which actually goes to the root cause of why I need Edoxaban, instead of taking Edoxaban. How can Natto have that blood thinning effect if it contains K-1?
Nattokinase contains vitamin K2 MK7 which is supposed to help shuttle calcium out of the blood vessels and into the bones. Calcium does tend to accumulate in plaques as well, right? So might that also be a MOA of how it works to reduce artherosclerosis?
This needs a study of the whole fermented food which has PQQ and other elements not just the isolated nattokinase.
One thing I don't understand, if Nattokinase is a protein, wouldn't the stomach acid denature it and the proteases break it down before it can be absorbed in the gut? Wouldn't the studies just be showing the benefits of the amino acids that make up Nattokinase?
You are correct. What the video doesn't tell and comments section does not discuss is need to take NK on an empty stomach with plenty of water to dilute stomach acids... in hopes the enzyme is not fully digested.
My own Anecdotal Experience with CAC score results done by a radiologist who had no access to my medical chart (I paid outside of my health care at Kaiser).
June 7, 2017 CAC 107 Cholesterol 216
August 5, 2019 CAC 193 Cholesterol 117 Had taken atorvastatin and K2, D3, magnesium for two years. Possibly had been taking bromelain
July 2, 2021 CAC 164 Cholesterol 249 Had stopped the atorvastatin but kept taking K2, D3, magnesium for two years.
July 10, 2023 CAC 292 Cholesterol 218 Unfortunately I took a tablespoon of lecithin every day for two years to lower cholesterol. I found out later that lecithin may lower your
cholesterol but it increases you TMAO which causes plaque. Did not take bromelain.
I now take K2, D3, magnesium, and bromelain. My cholesterol at the blood bank in May 2024 was 197.
K2, D3, and magnesium without anything to lower cholesterol DID decrease by CAC score from 193 to 164 in two years. It could be the bromelain. But I'm sticking with the K2.
K2 MK-7 100 Mcg
Don't worry about cholesterol being high. It's essential for life. If you want to lower cholesterol, then eat 12 oreo cookies a day for 2 weeks... yep it's absurd thing to do but 2x effective as a statin. But equally pointless. For your lipid panel focus on having high HDL and low Triglycerides. LDL Cholesterol ( ldl is just a transporter) only becomes an issue if you are eating sugars, refined carbs or vegetable oils.. all of which cause inflammation. Im no dr but there are plenty here on TH-cam explaining the plaque formation mechanism and blaming LDL is like blaming the firemen for the fire.. because they are always there. Statins are poison and serve no purpose but generate billions every year
@@niceadz6164 I've been a 100% vegetarian for 53 years (as has my husband who has a CAC score of 6). I make 98% of our meals using whole grains, beans, lentils, etc. I am 75 but I've never been to the ER, never been hospitalized, never had surgery, never broke a bone. I've been my own guinea pig to find out what stops plaque build up and what increases it. The plaque I now have is not causing any physical problems. I believe that for me it is that my body doesn't make K2 from all the greens I eat as it does for others. (I take probiotics.) I think it is inherited as both parents had heart issues in their 80s. But they weren't vegetarian.
Natto has a very low bioavailability hence much larger doses need to be studied to see if it has strong effect on reducing lipid formation, healing the glycocalyx and lowering BP.
For people who just eat natto every day, it would be interesting to know how many FUs are in a 40g portion of store bought natto. In Japan natto is considered a health food, but doctors usually say no more than 3 packs per day, or about 120g of natto.
Becuase 100g of nato is 2000 FUs
My concern is that natokinse is a blood thinner. That means you must be careful about dosage. If you take too much you can have trouble with blood clotting. Dental work, small cuts can become dangerous.0
Hey @Physionic, could you consider making a video about AC-11, a cats claw extract claimed to have longevity benefits? Im not sure if it’s necessarily good. Sometimes, don’t we need to expunge older things to keep things refreshed? Apparently, AC-11 reduces transcription degradation/error.
Serious question here. Do YT content providers get paid more if those of us watching watch the full ad instead of skipping ahead? Occasionally (i.e. 10% of the time) an ad appears that is interesting to me, and if I liked the YT channel like this one, I would consider watching it to completion.
No idea, to be honest.
I wonder if Serrapeptase added to natto would have a synergistic effect in reducing atherosclerotic risk? Serrapeptase is an enzyme derived from the silkworm and has been used in traditional medicine for various purposes. It is also believed to have fibrinolytic properties, potentially aiding in the breakdown of blood clots.
This video is highly informative.
At 6:19 all 3 show a decrease after 8 weeks so why the ( no effect ) I would say those are biased and anyone taking Nattokinase are taking it for a lot longer than 2 months including myself. I got rid of a clot on my right eye optic nerve in 7 days that caused total blindness. Before that I went 3 1/2 years taking statins and apixaban while the mini-strokes got worse, with gradual vision loss. I was taking 12,000fu/once a day to dissolve the clot. At 8:00 minutes the high dose is 10,800fu and I take 4 to 8,000fu as a low dose
A better question about nattokinase might be," does lifelong consumption, as per Okinawan/ Japanese population, even at lower dose , account for the vaunted longer lifespan," aka blue zone" effect"? In other words, can it hurt?
One would have to track the biological differences between said Japanese and whomever is the person asking the question. People become accustomed to a certain way of eating, and their gut microbiome adapts accordingly. Given how important our microbiome is in how we make use of food, this is just one of several important confounders to account for. So, you're right, and there's even more to it than that. Cheers!
The dosing of Natto is as important as when it is taken and the overall diet of the person in question. It is recommended that Natto be taken 20-30 (or longer) minutes before meals or 2-3 hours after. When taken with food it becomes a digestive supplement and most likely would diminish its heart and blood circulation benefits.
A person diet rich in sugars and carbohydrates would definitely impact the benefits of taking Natto as this diet triggers artery inflammation.
In order to really fully understand the benefits of natto a control group would need to follow the same diets, Natto dosing amounts and timing of the dosing relative to meals.
I generally enjoy your understanding of the scientific literature. I have learned a thing or two, but your conclusions/impressions here on Nattokinase are dead wrong on any metric.
Nick, your impression of it having mild to no effect, and that other supplements might be better, is obviously not true. Because doctors wouldn't be using it in hospitals and clinical settings as an official medicinal, for over a decade.
Perhaps next, you will like to go over studies on some other time tested medicines, shown effective in clinical use? This is what kills me with these vids. This kid is a good researcher, but does not use all the evidence. He thinks all there is,.... is these studies. When in Asia, they use it regularly in hospitals instead of the standard blood thinners that can cause bleeds.
Lumbrokinase is another proteolytic enzyme like Nattokinase also used in clinical settings. Lumbrokinase is used by some doctors to treat Lyme disease. It has the power to break down the biofilm of bacteria that causes Lyme disease.
"Nattokinase increases the natural ability of the body to degrade the blood clots in different ways and confer many advantages such as oral administration, efficacy, cost effective, long lasting effects, stability in the gastrointestinal tract, as well as its potential to increase the ability of body to produce plasmin and urokinase. It works by directly degrading the fibrin and plasmin substrate, transforms pro-urokinase into uPA, hydrolyses PAI-1 and enhance the level of tPA, which facilitate fibrinolytic activity. Furthermore, both in vivo and in vitro toxicology experiments have provided strong evidence about the safety of nattokinase for human oral consumption, as until now, there is no toxicity detected upon its usage. Nattokinase..... has been extensively studied in Korea, Japan and China.
Lumbrokinase exists as a complex of six serine protease isoforms. Each isoform has different molecular weights with a variety in fibrinolytic activity. It has a dual mechanism in clot degradation: acts on fibrin directly and activates plasminogen and converts it into plasmin, which subsequently induce plasmin-based clot dissolution." Role of Fibrinolytic Enzymes in Anti-Thrombosis Therapy - (nih.gov) (May 2021)
“Lumbrokinase is used as an oral supplement to support and maintain healthy cardiovascular function, and to treat cardiovascular diseases in clinical [practice] for more than 10 years." Lumbrokinase Protects Against Myocardial Ischemia-Reperfusion Injury - (nih.gov) (June 2018)
As mentioned in the study, it is used extensively in Asia. And you might think the US has the market on health care, but you would be sadly mistaken according to any statistics. There is much more evidence, but this is getting long.
I just want to add that the study he highlighted, using a high dose of nattokinase that he questions,.. is a follow up study by the authors. They did one earlier that was smaller, and had very similar, beneficial results on atherosclerosis and hyperlipidemia, just as the latter, much larger study did. And whenever you can duplicate outcomes, that is strong evidence the results were authentic...
Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants (Aug. 2022)
Clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidemia (July 2017)
You may ask why is the west slow on the uptake? Big Pharma can't have these cheap, safe, effective supplements wiping out their blood thinners and statins. Statins are by far, their biggest seller.
>>> ohbaby's substack
Definitely dosing, and duration too. Over a period of a year - how about 5 years of that dosing?
The dosing is pretty high for effective arterial clearing and people should take that with caution as it is a blood thinner.
Don't take too high of doses and don't take with other blood thinners.
I don't think it's a strong blood thinner, but at high doses it likely is.
I think a big part is having the blood "non sticky" for a long period, and the existing sticky slowly dissolves out.
Another big one is omegas, oc. Getting flaxseed oil or hempseed oil in your diet..., or just hte seeds themselves.
oc, omegas can be blood thinners too, especially fish oil (not sure of the others), so be careful with combining omegas with nattokinase (especially if in high doses).
Oh, and getting the toxins out - and exercise - get your body looking for food - it will find some in your arteries.
And Chanca Piedra - but not on same day. It's another blood thinner...
Pomegranates have something that reduces plaque.
And staying adequate in B vitamins
What do you mean get your body looking for food?
@@pattersonellen Metabolically speaking, ...is my understanding.
Some people take it because it's supposed to dissolve the spike protein from a totally necessary, and absolutely safe and effective, medical intervention that people were coerced into having.
🤔........☝️
More like mind controlled by mass psychosis methods
😆😂🤣
"Necessary"? Or unnecessary?
Dude.... great segue into your ad!
Thanks!
Have a question, taking 10.000fu for a few days now and is it possible that your intestine get disturbed? I mean have cramps every day
It probably has Inulin. Be careful with that.
Sure its possible.
I have just begin taken 10000 fu, my blood pressure got alot better just after a week testing it.
The enzymatic activity of Nattokinase is indicated by FU which stands for Fibrin Degradation Unit.
FDU was shortened to FU probably by someone who is not aware of American English idioms.
Very much enjoy your channel, thanks for the content. Any thoughts on the claim that natty-k is good for reversing the effects of/flushing the spike protein from the old vaxy vax?
Should i stop baby aspirin once daily.
Take nattokinse 4,000 u for two time a day instead?
No, I don't think so. Maybe do the substitution for one or two days a week only if you are otherwise healthy.
Taking aspirin daily will disrupt your microbiome, set you up for IBS and even stomach ulcers. Yes, take NK or any natural blood thinner.
I can say taking clopidrel plus ASA plus two NK
I was finding a lot of bruises.
Cut back to one capsule and significantly less bruises. Cut ASA and bruises stopped.
My experience with taking nattokinase (10,000 FU) is it lowers my heart rate about 5-10 beats/minute during exercise. I monitor my heart rate during HIIT exercises. I have to exert myself more to get my heart rate to 90% of max when I am taking nattokinase.
Would you consider that a good thing or a bad thing?
@@POVgames Personally, I don't think it is a good thing for HIIT. But if I are trying to burn a few more calories I can work out longer/harder and burn maybe 10% more calories.
With the pandemic, a lot of people were checking their blood oxygen saturation with an oximeter. I have COPD, so I was always checking it. Mine stood at 94 to 96. Deep breaths I could reach 97. But after taking these enzymes, Nattokinase, Lumbrokinase, I'm up to 97 regularly and have reached 99 for the first time ever with large inhales.
So, your heart rate dropping makes a lot sense,...since blood oxygen levels have improved and the heart doesn't have to work as hard.
Thank you.very helpful
I took it once for the anticoagulant abilities but having natural low blood pressure it was not good. Maybe the dosage was too high. Maybe I will try Natto the food from Japan 🇯🇵🗾 before totally thinking it's not for me.
Great work. It all comes down to any possible side effects and cost. Are there negative side effects? If not and you have atherosclerosis that current medicine is clueless on, why not give it a try? High dose seemed to lower my BP about 8-10 points. If I'm around in a couple years to remeasure my CAC and IMT, will decide then.
Can i take nattokinase with omega 3 fish oil
Maybe someone can help me with this. Taking NK helped me reverse angina symptoms within days. I also experienced many other positive noticeable effects. Sadly, I also started developing facial acne from it. I know most say that their skin imoroves while taking it, but I am apparently in the fraction of a percent of people who experience this. I can't understand why. Does anyone have an explanation?
Try a different more expensive- better (?) brand. There may be some other ingredient that is causing you a reaction. Maybe its a one time short lived thing as perhaps NK is having some cleansing action in your colon. Who knows? Are you still taking it? Did acne subside?
Unless they put the people with the higher doses on major diets with large amounts of weight loss, then it sure sounds like tripling the doses is what would have made the big difference. Any way that you look at it, they had very sizable improvements. There has to be something that caused that to happen. It might have been something else, but my money is on the nattokinase.
The study did not mention any other interventions given. It does appear that dosage was very important.
Breaking up fibrin ... wouldn't that result in poorer wound healing as well?
Theoretically, but I haven’t seen any reports that’s the case.
FWIW: high Serrapeptase use was a miracle for my sinus issues, but made my knuckle problems and bone spurs much worse. (This also happened to a friend using it.) A hand specialist said that scars help keep the joints sealed, and I imagine for all its drawback, the fibrin of the internal scars has benefits for some conditions.
I have you glasses I liked them and they are big so very good at keeping crap out of my eyes.
After oral ingestion, does nattokinase remain intact in our gastrointestinal tract?
Is it absorbed intact in our intestinal tract into our bloodstream?
Is it regarded as a foreign protein by our body? Any antibody produced against it?
Did the "large dose" natto group take it as one bolus/day or divided? I've been taking 24000FU/day but divided into 3 doses. Also taking 200 mcg of MK-7 and 45 mg of MK-4. And CIMT about 9 months after 1st one was noticeably improved.
Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants (Aug. 2022)
>>> ohbaby's substack
I used 6000FU daily for a year, no change in my BP or lipids. Didn’t get updated plaque scan or CAC test
If and when you do get that scan...
Please let us know.
6000 doesn't do nothing. the successful study used 10800 FU. and I am using even much more combined with lumbrokinase and serrapeptase. too low doses are a joke.
@@krix0043 - what's the difference between lumbrokinase and nattokinase?
@@tiz6549 Put that exact question into your favorite search engine.
@@tiz6549 5 points in Scrabble.
I was taking it to help with damaged nerves.