Dr. Lappin would I be right if I said that if the intrinsic clearance is low the extraction ratio will be low and thus hepatic clearance will be far less than hepatic blood flow. And if the intrinsic clearance is high, so will be the extraction ratio and hepatic clearance will approximate or even be equal to hepatic blood flow.
At a basic level you are correct but other factors can come into play. Remember CL(int) is determined in vitro, in the absence of any plasma or cellular binding effects (hence the term intrinsic). Also blood binding can have an effect and this this was not covered. The video was intended as a basic introduction and so be careful how far you use it for interpretations.
Great video ! Thanks for your explanations. Hope more people who study pharmacology come across your channel !
Dr. Lappin would I be right if I said that if the intrinsic clearance is low the extraction ratio will be low and thus hepatic clearance will be far less than hepatic blood flow.
And if the intrinsic clearance is high, so will be the extraction ratio and hepatic clearance will approximate or even be equal to hepatic blood flow.
At a basic level you are correct but other factors can come into play. Remember CL(int) is determined in vitro, in the absence of any plasma or cellular binding effects (hence the term intrinsic). Also blood binding can have an effect and this this was not covered. The video was intended as a basic introduction and so be careful how far you use it for interpretations.
@@GrahamLappin okay thanks🤝