Rhonda Patrick on Diet-Gene Interactions, Epigenetics, the Vitamin D-Serotonin Link and DNA Damage
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- เผยแพร่เมื่อ 20 พ.ค. 2024
- Our genes influence the way we absorb and metabolize micronutrients. Nutrigenomics looks at the influence genetic variation has over micronutrient absorption/metabolism and the biological consequences of this dynamic relationship. Our diet also influences which of these genes are turned on or off! Emerging evidence in the field of epigenetics has demonstrated that not only can we change the expression of our own genes within our own lifetime; sometimes these changes are heritable and affect our children and grandchildren. In this talk we’ll be exploring the intersection between genetics, nutrition, and environment: how your diet, micronutrients, exercise, heat stress, and sleep can change the expression of your genes and how this has profound effects on the way your body functions and ages.
Rhonda Perciavalle Patrick, Ph.D. is an assistant scientist at Children’s Hospital Oakland Research Institute working with Dr. Bruce Ames. She investigates the effects of micronutrient (vitamins and minerals) deficiencies on metabolism, inflammation, DNA damage, and aging in people. She also researches the role of vitamin D in brain function and dysfunction.
In addition to Rhonda’s active role as a researcher, she also functions as a science communicator for a broad lay audience via her web and video presence found at FoundMyFitness.com. She is passionate about disseminating health-related information in a way that the general public can easily understand. She is a frequent speaker and writer on topics ranging from general health and wellness, to diet and aging, to vitamins and their effects. It is Rhonda’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach.
Rhonda earned her Ph.D. in biomedical science from the University of Tennessee and performed her graduate research work at St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California, San Diego. She has done extensive research on aging, cancer and nutrition, and metabolism. - วิทยาศาสตร์และเทคโนโลยี
This young woman is amazing! She teaches a very complex subject at a level that a novice can understand and benefit from the entire lecture. There is absolutely none of the self centered blah, blah, blah that most TH-camrs bore us with.
She is actually 41 believe it or not. Middle aged. She looks amazing like shes in her late 20s early 30s
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I would like to complement the producer of this video. It is by far the best formatted lecture presentation I have ever seen on You Tube. The way you (I assume TheIHMC?) set it up, placing the presenter full size on the right of the screen, including full size, and clear, slides on the left, was phenomenal. This technique avoids the distractions of poor presenter coverage, and difficult to read slides, distracting from the content that the presenter is trying to share with the audience. We done, well done indeed! By the way, I'm also a big fan of Dr. Patrick.
Moronic viewpoint that is absolutely inapplicable.
jesus u got too much time on the hands lol
Dr. Patrick speaks with authority. I'm constantly on my patients about "eating their greens." Thank you for sharing this.
Still the coolest person on the internet
This interests me so much and it amazes me that doctors NEVER ask you what you're eating.
Right? Even more amazing is how doctors don't prescribe healthier diets to counter illness. Instead they pump us up with drugs when most of us just need a healthier diet.
Carmen McCabe There's no money in well patients
They are not nuriionists.They assume that peoples know what to eat.Nutrition is a personal choice.Not everyone is health conscious and majority of population is not trained to think food and guts all the time. They don't want that to be reminded and feeling guilty if they consume food.I call it nutrition deniers.Those poples are craving life and damage themselves involuntarely.
Mike Dorman - Nice! You're 100% correct. Dr. Joe Wallach (Vet and ND) is a great example of what you're talking about.
People know what a healthy diet is and they still don't adopt one. Furthermore people don't want to be told that they eat like shit. Kinda like telling a smoker that it's unhealthy for them. THEY KNOW
My health Guru. Even when I have to watch her videos more than one time to understand everything, she has a very good way to explain things which also makes me interested in learning more. Thanks Rhonda. :))
She has a PHD but you don't need to know all the details.
She is a sunshine
I want to make a baby with her
Basically eat, Good Fats, Lower your refined carbs, Eat your greens, Get some Sun, Go Exercise, Try Intermittent Fasting and be nice to your Mom
Thanks for that,
I'll get back to my cat videos.
The Golden Rule of nutrition.
and get a pet
I agree, and thank you for saying "be nice to your Mom." You're a kind person!
@@cathrynp3491 You're welcome! you should live long when you honor your Dad and Mum
Rhonda is so smart!
Rhonda Perciavalle Patrick has a Ph.D. in biomedical science.
THANK YOU. You are saving lives
I love this stuff!! so informative and has a lot of substance unlike most health practitioners!! Thank you Rhonda!
Around minute 20:00 to 22, Dr Patrick speaks about vitamin D levels of pregnant women affecting seratonin levels in the developing brain of a baby, and how it affects autism. I wonder if this relates to older women having a higher risk of autistic children, as with age, our ability to absorb vitamin D is reduced. It may also have something to do with children born at different months of the year having different personalities, as their mother experienced different amounts of sunlight exposure during different times of brain development.
…it made me remember the theory that autistic kids had mothers who were on antidepressants.
Interesting post. Remember humans over most of our time on the planet have usually had outdoor-type lives, & most babies were born in the spring (like most animals' young.
if my life wasn’t already devoted to another study I would solely focus on this, amazingly interesting information
Over my entire life, no Dr has ever wanted or offered to test my D3 level. Just recently I had to ask to have mine tested.
That's not good. My GP tests everybody's D3 for their yearly checkup and detected a dangerous deficiency in my case. Considering how common this deficiency is I'd be in the market for a new doctor if my current one wasn't on top of this.
IW Nunn go to grassrootshealth and Vit d council. They have been studying Vit d for years and years. Get your blood levels tested. Been doing mine for 20 years now
i asked so no such test
@Zapper Zapped I would think you need more with a low level as yours. The FDA recommended level is ridiculous. To avoid cancers, to need a level over 70. I know this as my level was 3 when diagnosed with cancer 10 years ago. With extensive research, I discovered the FDA which is controlled by Big Pharma isn't the authority on Vitamin levels. Just 2 cents
Try get the r3 thyroid test .effected by all this
She forgot to mention that folic acid isn't folate. It's the synthetic version and people with the MTHFR mutation, which is a LOT of people, have a hard time utilizing folic acid and it might actually work AGAINST what folate would do.
Jared Pitts you are correct
I'm a pre PA student who is currently taking genetics and this is awesome! Thanks for all the educating you do Rhonda!
So complicated subject you, Dr Rhonda, make it so simple and easy to understand. Thank you.
Dr. Rhonda Patrick is amazing! Love her and the work she does! Found her on Joe Rogan's podcast, which she is the guest on like 6 or 7 episodes (about 2 and half hrs each!). She is the reason I grow my own broccoli sprouts for my greens shake!!
This lady's scholarship is phenomenal.
What you do is so important, I wouldn't have an inkling as to why things have gone the way that they have if it wasn't for Rhonda and other health experts. Thank you.
23andMe is something I would NEVER use, as they are sharing/selling your information to the medical industry, and there is little regulation on how this could be used against us in the future. Though perhaps sounding conspiracy theory-like, we’ve already seen a similar thing with our personal information and many, many companies like Facebook, Experian, etc, etc.
I really appreciate how carefully you speak.
LOVE THIS GIRL
The government and medical community will never focus on preventative care that involves nutrition. It's too effective and profit prohibitive.
never say never - ai doctors are coming soon ...
People won't listen and won't eat what they're told to eat. We get the government and medical community we deserve
@@maxbooth179 we don't deserve bad health govt like we have now that are guided by big pharma and the food lobbying retards we have now...
Fascinating and informative lecture that is easily digestible and understandable. Thank you for sharing this information and thank you for the lecture/screen format - so much easier to follow the speaker and slides at the same time.
Who decides what medical schools teach? Tried to get a Dr to measure active vite D as well (none of the Dr's saw would !! ). TY for a good vid !
Thanks for sharing this very important video, Dr Rhonda Patrick ROCKS ! Keep On Truckin'
Absolutely stunning work
What bothers me is that mice don't eat the same things we do.
This is useful for our physical self... we need to also think about our real self based on our thinking and reasoning. Creating a self and then developing it within the permanent values. Why? Because this self is what we need to create which takes us to the next life... body is merely a carrier...
The physical self has a great influence on how, and what we think. In this life you cannot separate the two. Brain chemistry has a huge influence on how you think, and how you perceive the world.
Thank You Rhonda Patrick, for your marvelous work !!
You Go Girl! Providing a service with 23 and Me data is an excellent move. I'll do it as soon as it is available.
So interested in actually putting this information into practice and hope soon that the medical community will be using nutrigenomics to help their patients achieve optimal health. There is not a one size fits all approach to diet.
Most physicians are not able to make the time to keep up with these findings, however a paradigm shift is very soon in order, this is HUGE! It's going to lead to a major goldmine in the philosophy of mindsets, nutrition, fitness, drugs, and other environmental variables to enhance the health of our lives, and perhaps even alter the aging process. Now we can better understand why some genes have variance in phenotype rather than simply assuming its the environment (abstract statistical reasoning).
Love what you do @Rhonda Patrick!
I watch alllllll your videos and you have helped me ALOT!
Amazing talk! Love the picture of all the metabolic pathways. 🙃
🙋♂️✌🇨🇦
Thank you, Rhonda. You’ve been a wellspring of information for me the past couple of years.
I've never been so informed on a level that Wouldn't ever come up in a conversation wow however I have rewind a lot lol thx
One of my favorite speakers. Thanks.
Great information. Thank you !
Smart and very beautiful doctor
That is a good speaker ! - Tons of info, very fastly said. And structured. ... A BOMB.
And she looks awesome and young. I'm gob-smacked.
She is great!
Fantastic work, bravo!
Very good teacher. I am learning a lot from her.
Metabolism is complex indeed - individual.
Despite the accessibility of these research findings, the sick-care medical system's only tool is pattern recognition - excepting functional/environmental doctors, most physicians unaware of polymorphisms etc
HELPPP , I Had My Vitaman. D. Level tested 5yrs ago and it was 6 ~. That was at 40yrs old ~ Im 45 now and need it tested again like NOW ~ I have also had a lot of these problems you discussed in this lecture !
I want to rewatch this again and again
Don't forget that Omega 3, DHA and EPA are also found in seaweed...(kelp also has vitamin D) where the fish got it from in the first place.
m4xpl 4nck What is yr scientific background? I think Rhonda is better qualified to offer advice than you.
1 year late... Humans have essential omega-3's and 6's they must consume or they get a disease. DHA, EPA, and ARA are long chain omega-3/6 PUFA's that have to be converted from regular short chain omega-3 fatty acids like ALA into the more complex forms. If you have a FADS1 or FADS2 polymorphism, your body can't create the higher forms of fatty acids and therefore would need to get those from meat or supplement forms in order to be healthy.
Very informative!
Rhonda you’re amazing 💞
Dr Rhonda Patrick you are saving my life!
along with Elon musk
Thank you Rhonda!! awesome presentation!!
MD’s are like lazy cops; they are not proactive. They are reactive. They deal with your problems once you get them. A good cop (and DR) will be proactive and educate you on how to NOT BE a patient.
This is very good. Thank you for your work.
The only thing I feel like your trying to sell me is the improvement of my health.
Thank you.
So well spoken
Wow! That was fascinating!
amazing presentation as always! ;)
Love her.
Wtf where has all this information been from all the other doctors? Found Dr. Patrick from Joe Rogan.
They're busy getting you on a lifetime sub managing your "illness".
Joe Rogan University
Dr Rhonda eats this stuff for breakfast! Just amazing!
You are just so Good!
Thank you Ronda very interesting!
This Chica Rocks.
Thanks Rhonda, big fan , found you through JRE.
Help Help me Rhonda and you do. Not only do you help me health concepts but you, more than anyone else, help me build my vocabulary.
Me encantaría entender bendiciones para usted es muy inteligente todo lo que usted hace y sabe
The only Dr. that I really like!
Dr. Patriek's presentations are fantastic!
Metabolic pathways and phenotypes affect a second generation born that would influence the nutritional health or exposure to disease. My second question maybe there is not a direct response but can you give a general idea why most doctors do not ask questions if regarding nutritional intake,
Great information...
THC mimics serotonin... So being up took in the blood binding to platelets the source of munchies(increased demand for tryptophan)?
Brilliant 🤩
Fascinating! Makes me want to eat healthier but I’ll forego the spinach since it is too high in gut damaging oxalates.
Great talk. I haven't heard Dr. Rhonda talk about vitamin k2, an important co-factor, that should be taken along with vitamin d supplements. Can she address this too?
Agree
What about the high oxalate content of spinach. I’ve come across so many clients with high oxalates due to mold exposure which seems to be so much more common
I dont get it: center of Europe: no olive oil, no avocados, nearly no fish, only farming and cheese: and grand grandparents were always healthy with cheese, milk, meat...?? They didnt had any exotic imported food.
Because they were probably consuming most meat from grass fed, grass finished animals. In doing that, they get the nutrients in a much more bioavailable form than grazing on veggies themselves…
Someone please tell me how to repair degenerated discs or painful spinal discs
Could you do a presentation on bioavailability ?
She's just so good! Impressive! I would so like to do some work with her if she needs help!
Great video♥️♥️♥️
Has the Prometheus alternative on Found my fitness been released yet? This is gold.
Thanks
Does one get the vitamin d polymorphism from one of both parents? In other words if one parents had polymorphism does it get passed on to offspring?
Great talk. So much to absorb. Just remember the average punter does not get it. I’m a biochemist and it’s still a lot to assimilate.
I love Rhonda's videos. But I think she jumped the track a little in her answer to the last question.The questioner was asking for practical advice about whether or not most people should take multivitamins. She made some great points, such as too much folate being bad (because it can feed cancer), but my understanding is that she feels that --- in sum ---- yes, people should take a good multivitamin, unless they have a specific reason, such as a cancer diagnosis, not to. I think this was the information the questioner needed to hear.
I agree.. she said that "it's complicated" and that testing is important
I don't think she condones the use of a multivitamin nor do many well educated nutritionists. The research done to date lacks enough information to say that they are of any benefit. And until we know for sure that the benefits far outweigh the costs it would be prudent to rely solely on a "good diet". What that is is up to you to find out. There are foods that most agree are beneficial and those that are known to cause harm so it's best to read lots and construct your own diet. But of course your particular DNA might not react positively to those selected foods. You are unique.
Science has a long way to go before the answer to your question can be answered specifically to your situation.
Thank so very much Dr. Patrick.
You hard and brilliant work is GREATLY APPRECIATED and needed to millions.
Tim from Kansas
Thank You
Once we reach 65 & retire, the economic system hopes that we expire.
The level of chemicals that we are exposed to in our daily working lives shortens our lifespans IMO.
Also a Swedish study has pointed out that since 1945 the levels of different types of cancers has increased (excluding lung and skin cancers). This suggests to me that since open air nuclear testing began the levels of cancers seen in humans has significantly increased. Prior to 1945 many cancers seen today we're not seen or even as common.
A persons body only has to come into contact with 1 Radioactive hot particle floating around in the atmosphere to cause lasting damage and cancer.
Old people do cost too much to society. Maybe putting them down at birth is the answer.
You can't ignore the toxic load from glycophosphates, the increase in highly processed seed oils, and the horrible dietary recommendation all the "official" organizations have pushed.
What is the basis of Magnesium Daily allowance requirement?
How about those who only eat meat and are healthy?
What is the difference between to eat or make a vitamin D3 in human body
What about astragalus root for protecting/improving telomere length (combined with diet /D3/Mg of course) & impact on long healthy life?
Sounds good
Today we know that we know very little about the gut microbiome. So many carnivores doing so well with zero veggies.
Check in with them after 50 when the neglect and abuse takes hold
I am not so sure about the recommendation of vitamin be above 35ng/L. From I read recently our real need are more like 25ng/ L . We have been brainwashed 10 years ago about the promises of vitamin D supplementation, but it didn’t materialize by a reduction of cancer or diabetes or heart disease. But very interesting talk overall and great talker
Throught this video the term polymorphism is misused. Polymorphism is the same gene expresses differently in different tissues.
I have genetic MTHFR VDR Taq BSM both +/- i have low vitamin D b4 supplaments was 14 now at 24 with supplements. i have congenital heart disease too. recently diagnosed with 22q11 which is low calcium. oh also have high functioning autism. but lots of sensory issues,
32:39 Bless you
She's got off the charts smarts this one.
Thank you. This helps to explain the genetic link in obesity.
40:12 Healthy food sample - Yummmmmm
That second slide thoooo...
You know what, think I'm just going to fast forward to where you just tell me what I should be eating and how I should be eating it 👀
Gotta wonder in how many years....(if the planet still exists), will one be able to confront one's polymorphisms...and have genetic manipulation in vivo. Obviously, we'll be doing massive in vitro work...but, how about the whole organism? Does this make sense?
One of the issues with supplementation is that there is always a small percentage that get adversely affected so you have to be aware of caveats. For example, the first question from the audience was a man asking about eating spinach: too much spinach eating by older males can be a problem with regard to excessive iron levels. Same for Vitamin D where some people with kidney or liver issues which affect the conversion of Vitamin D, where some people may make TOO much D and suffer some toxicity effects. For the most part, it seems mont people are D deficient. Dr Holick should get some credit for his long-time work to push for higher D levels and more awareness on D deficiency.