Calcium channel blockers. Mechanisms of action and therapeutic uses of calcium antagonists.

Calcium channel blockers or calcium antagonists are a diverse group of drugs used to treat hypertension, angina, cardiac arrhythmias, cerebral vasospam, epilepsy and neuropathic pain. This video explains the mechanims of action of these drugs and relates them to their effects and their clinical uses. In particular it explains why verapamil selectively affects the heart, dihydopyridines like amlodipine and nifedipine selectively affect arteries, and why diltiazem combines the actions of the other two drugs. The gabapentanoid drugs, gabapentin and pregabalin, which are used to treat epilepsy and neuropathic pain, are also covered.
00:00 Overview of mechanism of ation of calcium antagonists
02:39 Therapeutic applications of calcium antagonists
04:59 Calcium channel genes and isoforms
08:13 Calcium channel alpha1 subunits
10:37 Drug interactions with Cav1.2
13:02 Implications of drug interactions with Cav1.2
18:05 Summary

[@takyc9344]

quality video

[@professorGpharm]

Thank you.