Firstly, thank you so much Prof. Catterall for taking the time to do these types of videos. It is tremendously enjoyable to watch these fascinating machines and begin to understand how they work! Secondly, I'd just ask, what would prevent a tiny H+ ion for example from leaking through these channels. Apologies if this is covered elsewhere.
I'm scratching my head over the same thing. For the sodium channels, it's known that K+ is just physically too big to fit, but Li+ can easily get through them. Why not H+? In part 2 he made it seem like several Na+ ions get 'stuck' by coordination in the pore, and they're only pushed through when another ion Na+ bumps into them from behind. Like a Newton's cradle, I guess! Perhaps H+ doesn't provide enough of a push to unclog the sodium, so to speak? He seems to be saying 2 Ca+ get 'stuck' in its pore, too. I dunno! Pretty interesting talk, but I wish he addressed that!
I was wondering about calcium channel blokers for HBP...my God...how can I interfere in such complex mechanism of the body with a drug??? I am scared about...
Why are the calcium cells predominantly found in the cardiac/nerve cells though? Does this information apply to all cells? Just to a lesser extent? Or are cardiac and nerve cells actually unique in the fact that they use calcium to enhance signaling
Came here to begin my understanding of the relationship between calcium ion channels and fibromyalgia. Thank you.
When you can take a complex topic and make it easily understood, Bravo.
this was my professor in medical school. i miss those days!!
was he a nice person?
@@katstakashi3459 he was very nice. i really respect him. humble too
Outstanding Presentation !!!!
Great talk. Thanks
Very nice talk! Learned a lot! Thanks!
Firstly, thank you so much Prof. Catterall for taking the time to do these types of videos. It is tremendously enjoyable to watch these fascinating machines and begin to understand how they work!
Secondly, I'd just ask, what would prevent a tiny H+ ion for example from leaking through these channels. Apologies if this is covered elsewhere.
I'm scratching my head over the same thing. For the sodium channels, it's known that K+ is just physically too big to fit, but Li+ can easily get through them. Why not H+? In part 2 he made it seem like several Na+ ions get 'stuck' by coordination in the pore, and they're only pushed through when another ion Na+ bumps into them from behind. Like a Newton's cradle, I guess! Perhaps H+ doesn't provide enough of a push to unclog the sodium, so to speak? He seems to be saying 2 Ca+ get 'stuck' in its pore, too. I dunno! Pretty interesting talk, but I wish he addressed that!
Is there an electrochemical gradient of H+ across the membrane? That’s what makes things happen.
They might be reacting with the carbonyl functional group and not entering the channel.
I was wondering about calcium channel blokers for HBP...my God...how can I interfere in such complex mechanism of the body with a drug??? I am scared about...
This video is just so good 👍
Great lecture sir
Why are the calcium cells predominantly found in the cardiac/nerve cells though?
Does this information apply to all cells? Just to a lesser extent? Or are cardiac and nerve cells actually unique in the fact that they use calcium to enhance signaling
This is supercool.
THANKS!
GRATE