Shuttle Mechanisms (Malate-Aspartate and Glycerol-Phosphate)
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- เผยแพร่เมื่อ 27 ต.ค. 2013
- Moof's Medical Biochemistry Video Course: moof-university.thinkific.com/...
This video describes why NADH's from glycolysis can be worth 1.5 OR 2.5 ATP.
For Related Practice Problems with Worked Video Solutions on Enzymes, visit courses.moofuniversity.com.
This is the only video that got the shuttle concepts through to me! Thank you!!
end of 2018, first year med student; this helped a lot!!!
Wow thanks! I have a biochemistry exam in T-3 hours and 59 minutes and this is extremely helpful. Greatly appreciate it.
your videos are the best! i cant stress on that enough, you deserve way more views. God bless you man, you saved me countless times through these videos
That was great! Thank you so much for the clear explanation; especially the fact that you made the jargon make sense.
Fantastic explanation - concise and complete. Thank You.
I'm preparing for the Step 1, there is only 1 sentence on this in first AID 2015 pg 101, and this clarified it, thanks!
Aye Papito Lol. Whoa. Interesting. I'm glad this video helped! :]
+Aye Papito Same! This wasn't explained at all in First Aid or Kaplan. Great video.
I ended up here reading first aid , thank you !!!
I think these are the same lectures as Khans ?
I use the same drawing software as Khan Academy, but they're not Khan Academy videos. They're Moof University videos. Happy studying! :]
Haha , your voice is similar to the khan academy videos too . But thank you so much , it's a great lecture .
Which software is this ? I bought a wacom intuos draw , maybe I can make my own videos like you guys !
This video was awesome! Really clarified this topic for me, thank you!
This is a great explanation -bless you for this content!!
This explanation was waaay better than how my study guide and my lecturer explained it. Thanks!
Great Job! Thanks for talking slowly.. That helps a lot
This is amazing! Thank you!!
All your videos are incredible! Thanks so much :), you would make an awesome lecturer!
sir really easy way to expln and yah lasts longer in my head.thank u fr making my life easy😃
You're the man! thanks a lot.
Really clear explanation! Thank you so much. :)
Thank you, I was so confused !!!
Thank you!
This was such a great explanation! Very helpful. Thanks so much!
Janelli Mendoza Thanks! Happy to help!
This was very helpful thank you.
Thanks for the help! You break the jargon down really well! :)
Charlotte Thorns Sure thing! Thanks! :]
Amazing, thank you!!!!
I had problems understanding these shuttles but it's clear now thanks
SO NICE! Thank you
This was extremely helpful way better than my lecture
U made it a lot clear than my prof
THANK YOU for this vid.
been trying to understand those for a week with no hope but now It's clear
Thank you so much
ahmed naji Happy to have helped, dude!
THANK YOU SO MUCH!!
so helpful!! thank you
Hey! Great explanation. thank you. Got a question though... what is the difference between the Glycerol-3-phosphate shuttle and the glycerol 3 phosphate dehydrogenase that is located in the inner membrane. Because I am a little bit confused because supposedly this dehydrogenase just oxidizes and reduces but nothing gets transported into the membrane other than the electrons that are later transferred onto Q. Can you help? Thanks again.
AND THE MYSTERY LIFTS!
Thank you :)
Lol. Awesome. You're welcome!
Good explanation!
THANK YOU!!!
fantastic!
Thats ver helpful. Thank you
Love it!
Very good
thanks!
you have a REALLY deep voice...
OMG! Thank you so much! Finally made sense to me!
You're very welcome! I'm glad it makes sense!
Great vid! Helped me understand!!
Thanks! I'm glad. By the way, your username is one of the best I've ever seen, bih. Haha!
Really helpful! Thanks a lot! :)
One thing I don't get though - how can DHAP diffuse out of the mitochondrion if it can't enter without being converted into glycerol-3-phosphate?
Sweet! I'm glad it helped!
DHAP just happens to be permeable, in this case. :]
Awesome!!!!!!!!!!!!
thank you so much:)))
Thanks allot man!
With the malate aspartate shuttle as explained here, the mitochondrial matrix is losing Ammonia to make Aspartate, while the cytosol is gaining Ammonia from the Aspartate, so how does this come back into balance?
you earned my subs hehehe thank you for explaining very well
Thanku🌻
Thankyou
Great explanation, very clear. You'd make a good professor or tutor if you decided to go down that path in life
Thanks! I'm traveling down that path. It's good to know others feel the same way I feel about it. :]
bless your life
this makes me happy. professor did NOT explain it nearly this well, and was entirely confused.
question: why does the second shuttle even exist if the first one is more efficient?
+Spencer DR That's a really good question, dude. It's something I've wondered myself, but I don't know if there's an accepted explanation among scientists. There may be, but I haven't stumbled upon it.
+Moof University. Hi good video. The Glycerol-Phosphate is much faster in regenerating NAD+ which is why, its in skeletal muscle and brain. Because its more important to make NAD+ then ATP. The Malate-Aspartate uses a number of intermediate like glutamate. You have low glutamate you cannot transport the aspartate back into the cytosol which will shut down the cycle.
helpful
thank u
Can someone plz tell me how many total ATPs are formed in both of these shuttles respectively ?
Can anyone explain why NADH cant get in membrane and but in the matrix theres NAD+. charge?
so just to make sure I have this right the Glycerol 3 Phosphate shuttle is the way electrons get passed into Complex II and the Malate Aspartate shuttle is how electrons get passed into Complex I?
Glycerol 3 phosphate is the pathway to transfer electrons of NADH into FADH2, where FADH2 reduces ubiquinone into QH2, traveling directly to Complex 3
what does it mean when its worth ATP?
شكرا يارجل .. thank u so much ,
amal1994ify You're welcome so much!
I have read and read and I just could not understand. Thanks to you I am clear on what is going on with these transporters.
Tiky Coronado Sweet! Happy to have helped!
Thank you 💞
You're welcome!
Best
Hello? Hope you can clarify my question. So the organelle involved in the two shuttles is mitochondria right?
Yes
If malate dehydrogenase can reoxidize NADH, then why does it need to cross the mitochondrial membrane, can't it just go back to taking part in glycolysis by staying in the cytosol ?
Thanks for the videos, they're great !!
There is no WHY to Biology questions answer, but you should keep in mind that the extra generated 2 NADH were produced in the cytosol. 😑
if you taught a class, I'd take it :)
I read somewhere that the Malate aspartate shuttle transfers the electrons to complex 1 in the ETC while Glycerol phosphate
shuttle uses complex 2. Does anyone know if this is true?
That's because the resultant NADH from the Malate-Aspartate Shuttle gives its electrons to complex I of the ETC, while the resultant FADH2 from the Glycerol-Phosphate Shuttle gives its electrons to complex II of the ETC. Watch my three part video series on the Electron Transport Chain (ETC) to learn more about that.
Thank you!
Thank you...
You're welcome!
3:28 is start of glycerol phosphate shuttle :)
This was so helpful! Please work with a textbook company since you have much better competence at explaining! Lol thank you again
A+
MARRY ME.
whats so funny about saying mammalian !?