Epigenetics| DNA methylation | Histone Modifications| Bisulfite sequencing| Genetics for beginners

This video lecture explains
1. What is epigenetics?
2. What are different factors and processes affecting epigenetics?
3. What is DNA methylation?
4. How DNA methylation regulates gene expression?
5. What is bisulfite sequencing?
6. What are histones?
7. What is histone modification?
8. How histone modification regulates gene expression?
9. What are the end points of epigenetics?
Image Credit: Wikipedia
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0:00 Epigenetics: Epi+ Genetics Literally means "above" or "on top of" genetics
3:01 DNA methylation, the addition of a methyl group, or a chemical cap, to part of the DNA molecule, which prevents certain genes from being expressed.
7:30 (Without histones, DNA would be too long to fit inside cells.) If histones squeeze DNA tightly, the DNA cannot be "read" by the cell. Modifications that relax the histones can make the DNA accessible to proteins that "read" genes.

[@mariaerasoaraucana25]

very clear and simple, thank you

[@BiologyLectures]

Thank you very much 😊

[@jonahliealegre9130]

Thank you so much for this very clear explanation. 💯

[@BiologyLectures]

you are most welcome. Wish you all the best

[@predator8210]

Very good explanation!

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[@gs35364]

Thanks sir for making it understandable

[@BiologyLectures]

You are most welcome

[@investincrypto2859]

Excellent explanation. Keep rocking.

[@BiologyLectures]

Thank you, I will

[@lolitalool2830]

thank you so much for this very useful and clear lecture💯

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[@hlufe.e]

Keep continue cover genetics at higher level

[@BiologyLectures]

We will certainly cover more topics on advanced topics. Please feel free to suggest some if you have any. Thank you.

[@Jillani984]

Very helpful
Thank you sir

[@BiologyLectures]

You are most welcome.

[@seema.sankeshwari]

I feel like i have got my dronacharya to learn genetics... Sir thankyou so much sir . Keep uploading about genetics,, there's a list of genetic test and etc etc things listed in harvard online courses kindly explain those not everyone is affordable to learn there. Please sir please. And please explain about base editing expt undergoing in Japan for genetic disease treatment

[@BiologyLectures]

Thank you very much for the kind words. Please also visit the following playlists
Molecular and cell biology methods
th-cam.com/video/sa3c1097hCw/w-d-xo.html
Genetics
th-cam.com/video/bibkF_7a2Yo/w-d-xo.html
For nucleotide therapy, please visit the following links
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th-cam.com/video/c82MFpfwNM8/w-d-xo.html

[@seema.sankeshwari]

@@BiologyLectures yes daily am doing notes from your videos.. blessed to have such teacher.. thankyou sir thankyou so much🙏🙏🙏🙏🙏

[@BiologyLectures]

@@seema.sankeshwari you are most welcome.🙂

[@davidmansaray3563]

Perfectly put!!!

[@BiologyLectures]

thank you.

[@simplysatisfying6572]

Very helpful lecture plz make more such videos 😍😍

[@BiologyLectures]

thank you. We will

[@dikshyapanthi7681]

Excellent lecture 😃

[@BiologyLectures]

welcome

[@Hari788]

Very well explained. Thanks a lot sir 😊

[@BiologyLectures]

Most welcome

[@nishadhenwal7756]

Thank you sir ❤️❤️❤️

[@BiologyLectures]

Most welcome

[@telugumusicalworld5606]

Thank you

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[@ICDSSupervisorExamGuide1]

thankyou so much sir,

[@BiologyLectures]

You are most welcome 😊

[@sayunijay4742]

thankyou so much

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You are so welcome!

[@willperez1107]

very good

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[@stephenleighton4050]

Question..... can anyone explain or give clarity on the following ... does any change to typical Purine & Pyrimidine, folate, B6 or B12 pathways during pre or early post natal periods result in heritable genetics that could be passed from that baby should they procreate in later life?

[@hassanhijazi4757]

One thing to add is that not only tails but also histone cores are modified.

[@Jonathan-kl6zt]

You should redo your lecture with better acoustics. And a bit slower

[@maume8278]

Thank you so much 🙏🏼

[@BiologyLectures]

You’re welcome 😊

[@basharj7526]

thanks for the great explaination ..... I just wanna ask about the resources you used plz as I want to go into further details ?

[@BiologyLectures]

Thank you. We used multiple resources . Please find the link below for one of the sources used w3.biosci.utexas.edu/atkinson/Epigenetics2014/Epigenetics2014/Readings_files/Ch%201%20Overview.pdf

[@vatsalbarad253]

Superb

[@BiologyLectures]

Thank you.

[@Priteshlodh]

Hello Sir, does epigenetic changes are reverseible?

[@BiologyLectures]

Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence

[@westfield90]

The level of the complexity of the body just went through the roof. Finding therapies and new drugs for diseases just became very very very difficult if genes are being turned on and off by almost any external factor.

[@genetilocos3105]

I have a question that is making me sick. I thought that methylation should always be interpreted as a repressive mark. So, how is it that H3K4me3, H3K36me, and H3K79me for example could lead to gene expression}? thank you

[@BiologyLectures]

DNA methylation is a fundamental epigenetic event associated with physiologic and pathologic conditions, including cancer. Hypermethylation of CpG islands at active gene promoters leads to transcriptional repression, whereas hypomethylation is associated with gene overexpression.
Reference: pubmed.ncbi.nlm.nih.gov/21692051/#:~:text=Background%3A%20DNA%20methylation%20is%20a%20fundamental%20epigenetic%20event,repression%2C%20whereas%20hypomethylation%20is%20associated%20with%20gene%20overexpression.

[@genetilocos3105]

@@BiologyLectures thank you very much! I will check out the paper. So, there are histone's methylations that are repressive (like H3K9me3 or H3K27me3) and methylations that are permissive, right? Maybe it depends on context, signals, or that are made in different aminoacids? I will read the paper btw. Thanks again!

[@nixodian]

Epigenetics and methylation same? Thanks for clarification

[@BiologyLectures]

In addition to methylation, epigenetics also contains histone modification.

[@amogelangsekhu3906]

Does DNA methylation only prevent certain genes from being expressed ?

[@BiologyLectures]

Not all genes are active at all times. DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression.

[@jitendrakanwar6125]

Can you explain the causes of epigenetics....🙏

[@BiologyLectures]

Environmental Factors: Environmental exposures, such as diet, stress, pollutants, and lifestyle choices
Developmental Processes: Epigenetic changes are crucial during development and can result from the sequential activation or inactivation of specific genes
Disease and Pathological Conditions: Epigenetic alterations are implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

[@daliabahris208]

Very hard to understand.

[@BiologyLectures]

Please watch and rewatch again. Hopefully you will understand

[@easycooking8570]

Thank you

[@BiologyLectures]

You're welcome