Nice summary. Like in many fields, technological discontinuities can always occur in life extension biology which would negate any claims thus far about how plausible radical life extension is. Never underestimate the power of breakthroughs in research.
Before the Wright brothers, powered flight for mankind was considered not just "implausible" but downright insane. 70 years after the Wright brothers, we were on the moon. Its silly to predict where & how quickly tech will advance. Putting the limit on significant life extension this century seems rather bold. We do not know what(and how much) we do not know. The germline is millions of years old, so the question "how long can we possibly live?" has in a sense already been answered. If there was an inherent upper limit on how long DNA damage could be mitigated, or how much cellular waste could be accumulated or how much epigenetic change could be managed or how many times telomeres could be rebuilt (etc etc) , then none of us would be here. Everything is fixed in the reproductive cycle. Unless you believe in magic, the mechanisms of that fixing must be amenable to investigation and replication. Of course we cannot know how large the task & how long the struggle, but with incredible Research going on + AI + ever faster computers its hard to argue we will make no major progress in a couple of decades, never mind 75 years.
In the US - the bottleneck is often the process for getting the breakthru from the lab past the FDA. This encompasses both the timing for the trials, and the financial incentive to spend the millions of dollars needed to fund those trials.
Wishing Sheekey a most happy 2025. Thanks for all your videos helping me and so many others to recover from bad education and/or brain damage caused by the side effects of same.
Happy New Year and wonderful summary! One note: I think Olshansky et al., in their rather pessimistic article, did include the caveat that we could achieve radical lifespan extension (another 10+ years) if scientists develop new therapies that slow/reverse aging. In order to reach their conclusions, the researchers assumed that scientists wouldn't develop any breakthrough therapies in this century.
Happy New Year, and thank you for another great video! I LOVE your work and look forward to seeing what you publish in 2025! I'm an optimist when it comes to longevity science, and I read the paper about the "Implausibility of rapid life extension." It has merit, but I think the subject is somewhat misleading. Based on how life extension has occurred over the past century, it may be that we have more or less tapped that resource through sanitation, safety, proper nutrition, etc. But it can't predict what advanced methods may offer in the coming years. Things like protein blocking and editing gene expression were akin to dragons and fairies until only recently.
Please tell us how is life in Japan as a foreign scientist. A simple vlog with what you enjoy (or not) would be very interesting and not only to your subscribers. Have a great 2025, full of research breakthroughs 😊
Happy New Year 2025 🎉 innovation cannot be tell in advance. Cross finger there will a huge breakthrough in 2025 with for example stem cell. Although not my favorite. Looks complicated and thus expensive… happy new year again!
Its not surprising to me. The interventions testing program literally never reproduces any other lab's results. At first I thought they were exposing other work, but at this point they might be the issue. How can so many independent labs be so wrong?
With regards to life extension being implausible, it's only looking at current trends. That's like going back to the nineteenth century before modern medicine, and come to the conclusion that life expectancy would increase in the twentieth century. Of course past trends won't show show it. Life extension will only occur after the treatments are implemented.
Amazing video as always! What would you recommend taking as a class in order to grow and help this field? I’d like to try! Do I have to go through a full on master degree or some online classes can get me up to date? Also, what do you think about rapamycin? It seems like it can regulate the immune system response. Should I try that? Already trying out NR at the moment!
It's a bit disheartening to think we might not witness radical life extension within this century. Even so, I’m keeping a close eye on advancements in AI and quantum computing. I’m also a great admirer of the American biologist Michael Levin-his work seems to hold incredible potential. Let’s stay hopeful-our future may very well depend on it. 🤞
Bio Electricity is at least part of the answer we seek, but is is incomplete as in what causes he bio electricity to do what it does such as quantum entanglement and super positions by the trillions of same per h=plank second, impossible unless C is exceeded. Thanks for this thinking video.
92% of animal studies fail to translate to human results, according to SageJournals. Would love it if new videos could focus on real human-focused results, rather than concepts like the ones featured here
Ceo whacked and directors left. Water powered car guy also whacked and blueprints and car vanished. Now repeat after me in complete sarcasm everyone. WE LOVE YOU GOVERMEEEEEEENNNNNNNNT
Happy New Year!
Happy new year. wish you all the very best always ❤
Happy 3025
Happy new year, happy to have u here 🙆♂️💜
Happy New year 🎉
Excellent slow lecture. Thanks for the right speed of lecture.
Nicely done!
Thanks for your efforts, you are so smart! Happy New Year!
Nice summary. Like in many fields, technological discontinuities can always occur in life extension biology which would negate any claims thus far about how plausible radical life extension is. Never underestimate the power of breakthroughs in research.
Before the Wright brothers, powered flight for mankind was considered not just "implausible" but downright insane.
70 years after the Wright brothers, we were on the moon.
Its silly to predict where & how quickly tech will advance.
Putting the limit on significant life extension this century seems rather bold. We do not know what(and how much) we do not know.
The germline is millions of years old, so the question "how long can we possibly live?" has in a sense already been answered.
If there was an inherent upper limit on how long DNA damage could be mitigated, or how much cellular waste could be accumulated or how much epigenetic change could be managed or how many times telomeres could be rebuilt (etc etc) , then none of us would be here.
Everything is fixed in the reproductive cycle. Unless you believe in magic, the mechanisms of that fixing must be amenable to investigation and replication.
Of course we cannot know how large the task & how long the struggle, but with incredible Research going on + AI + ever faster computers its hard to argue we will make no major progress in a couple of decades, never mind 75 years.
In the US - the bottleneck is often the process for getting the breakthru from the lab past the FDA. This encompasses both the timing for the trials, and the financial incentive to spend the millions of dollars needed to fund those trials.
Wishing Sheekey a most happy 2025. Thanks for all your videos helping me and so many others to recover from bad education and/or brain damage caused by the side effects of same.
Happy New Year and wonderful summary! One note: I think Olshansky et al., in their rather pessimistic article, did include the caveat that we could achieve radical lifespan extension (another 10+ years) if scientists develop new therapies that slow/reverse aging. In order to reach their conclusions, the researchers assumed that scientists wouldn't develop any breakthrough therapies in this century.
Thank you! I’ve subscribed your channel and watched the great discoveries of latest research for last 3 years.
Happy New Year😊from South Korea.
Thanks, so well explained.
Happy New Year, and thank you for another great video! I LOVE your work and look forward to seeing what you publish in 2025!
I'm an optimist when it comes to longevity science, and I read the paper about the "Implausibility of rapid life extension." It has merit, but I think the subject is somewhat misleading. Based on how life extension has occurred over the past century, it may be that we have more or less tapped that resource through sanitation, safety, proper nutrition, etc. But it can't predict what advanced methods may offer in the coming years. Things like protein blocking and editing gene expression were akin to dragons and fairies until only recently.
Thx for info ℹ️ from Sweden
Happy New Year Eleanor! Keep up the good work! 🎊🌌🎄🍓❤️
Thanks for making this - what a great resource! It's hard to keep up with the literature and this is like a cheat sheet for the whole year. Well done.
Happy new Year . Amazing Video and Information, Thank you.
Yesss!!!!!! Thank you!!!
Happy new year from Vietnam 🥰🥰🥰🥰
Good Stuff. Great year. Happy new year.
This is a really good summary of 2024 aging research. 🙂👍
Happy New Year! 💙💙
Please tell us how is life in Japan as a foreign scientist. A simple vlog with what you enjoy (or not) would be very interesting and not only to your subscribers.
Have a great 2025, full of research breakthroughs 😊
Happy New Year 2025 🎉 innovation cannot be tell in advance. Cross finger there will a huge breakthrough in 2025 with for example stem cell. Although not my favorite. Looks complicated and thus expensive… happy new year again!
あけましておめでとうございます‼‼
Great video! Happy New Year!
I think with AI we will have huge break throughs with health and anti aging in the next 10 to 15 years
13:45 Interesting that Alpha-ketoglutarate had no effect in male and female mice as that has been marketed (hyped) as a longevity supplement.
Its not surprising to me. The interventions testing program literally never reproduces any other lab's results. At first I thought they were exposing other work, but at this point they might be the issue. How can so many independent labs be so wrong?
@@CommanderRiker0 One reason may be that they have commercial interests.
With regards to life extension being implausible, it's only looking at current trends. That's like going back to the nineteenth century before modern medicine, and come to the conclusion that life expectancy would increase in the twentieth century. Of course past trends won't show show it. Life extension will only occur after the treatments are implemented.
Thanks for the 2024 recap. Catching up on all the science before 2025 :)
Do you think there are more such advances every year?
Amazing video as always! What would you recommend taking as a class in order to grow and help this field? I’d like to try! Do I have to go through a full on master degree or some online classes can get me up to date?
Also, what do you think about rapamycin? It seems like it can regulate the immune system response. Should I try that? Already trying out NR at the moment!
It's a bit disheartening to think we might not witness radical life extension within this century. Even so, I’m keeping a close eye on advancements in AI and quantum computing. I’m also a great admirer of the American biologist Michael Levin-his work seems to hold incredible potential.
Let’s stay hopeful-our future may very well depend on it. 🤞
Yeeeeeeeeeeaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa finally, puh, was wondering where the new video went to
I hope curing scars become a reality soon!
yo, that's cray cray!
Ha eye opening!
Are you living in Japan for work or moved there permanently?
Bio Electricity is at least part of the answer we seek, but is is incomplete as in what causes he bio electricity to do what it does such as quantum entanglement and super positions by the trillions of same per h=plank second, impossible unless C is exceeded. Thanks for this thinking video.
92% of animal studies fail to translate to human results, according to SageJournals. Would love it if new videos could focus on real human-focused results, rather than concepts like the ones featured here
Telomir-1.
Ceo whacked and directors left. Water powered car guy also whacked and blueprints and car vanished. Now repeat after me in complete sarcasm everyone.
WE LOVE YOU GOVERMEEEEEEENNNNNNNNT
Happy New Year!
Happy new Year!