Molecular animation - Tech Talk by Drew Berry wehi.tv (2022)
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- เผยแพร่เมื่อ 8 ส.ค. 2022
- Animation Tech Talk by Drew Berry wehi.tv - AMI.org 23 July 2022
"How to Stop your Molecules Looking Like They ‘Know’ Where to Go - The Problem of Agency in Molecular Animation"
A problem that plagues many 3D molecular animations is the way molecules are presented moving around the cell - flying straight to their enzyme destinations as if they know where to go. Drew Berry will present a few of his considerations, tricks and techniques to reduce the appearance of molecular agency, while delivering stochastic-looking moving molecules that are fully under animator control for choreography and storytelling.
Session Takeaways:
1. Wrangling time scales at a quadrillionth of a second while making molecules meaningful to watch
2. Wandering randomly while getting there on time - วิทยาศาสตร์และเทคโนโลยี
these are, and always will be, my FAVORITE animations for learning and exploring molecular biology.
you are a legend, Drew Berry! thank you for these masterpieces
Yes, thank you Berry
i would pay my entire life savings for this to be a video game. imagine exploring this in VR?!!
Walking around the electron transport chain lol I’d flip out it’d be so cool
When I saw the stochastic movement in the videos, I knew it was something different. It's incredibly excellent work.
One of the biggest ‘aha!’ moments in my life came form watching one of your first videos. It gave me a glimpse of understanding what we are made off and how life works in general on a molecular level. Thank your for allowing this.
And as I greatly appreciate your efforts to ‘rhythm’ the movement I would also love to see the real randomness in one or your videos.
Thank your for your amazing work.
Incredible work sir. But I am astounded. How can all this near infinite complexity work altogether at once, mind boggling so, multiple machines in perfect harmony and people still think it just happened. I don't have that kind of faith. I would have a better chance of jumping off the earth, getting to Jupiter and back, holding my breath the whole time and landing whole back at my starting point on earth than the common assumptions of materialism. To say it has the "appearance" of design is a death defying leap of presumption. It must take incredible, awesome faith that defies logic to think it's all by chance.
one neat thing about alpha fold is it gives a confidence score along with the domains it predicts. i've messed around with it some, and it definitely doesn't get everything right.
I asked for a behind-the-scenes video, and you guys delivered! Seriously, this was exactly the kind of thing I had hoped you'd make. You are all awesome!
When a work sideline turns into new branch of molecular biology. The AI engine will create a new research tool from an illustration system. Well done Drew. Cheers Pierre
I. LOVE. THESE. VIDEOS..! they're Art and Science and learning and fantastically-enthralling all-in-one.! YOU are APPRECIATED......
As a retired computer tech, hardware/software installation/support, I'm glad you told us a bit about your path through your career. It seems you started out around the same time as I did, and like you, I remember how computer graphics evolved, CGA, EGA, SVGA, all those things that were new to us, and growing by the minute.
This is fantastic Drew! Your 2006 animation of apoptosis inspired me to complete my PhD. Would
love to see you do this as a Wednesday seminar.
Wanting the backbone of the apoptosome on the side of my back or as a full sleeve for a tattoo! Happy you're inspired-what'd you major? Congrats, Lee! 🎉
Can't get enough of this kind of animation. My favourite is the movement of pseudopodia.
Drew's animations are just staggering and reflects on his extraordinary ability to collate literally decades worth of molecular research. Indeed built on the shoulders of Nobel giants. Drew often references Brownian motion to basically move the "soup" around to instigate enzymatic reactions within the cell and this has puzzled me whether it's sufficient. Which led me to latest research from Harvard that the cummulative movement of all of the molecular motors such as dynein and kinesin produce waves in the soup so that it aids reactions. Totally fascinating from my humble I.T. background that I can view in my life time the intricate level of life itself. Please do not stop showing us such molecular marvels. I'd personally vote Drew for a knighthood for his contribution to understanding biological functions.
I'm not a biologist, I'm a mechanical engineer, but it's been some years that I'm into biology and i see videos and seminars just because it's so amazing to think that there are trillions of this tiny machines inside me and every living creature and works perfectly every time, and it's more amazing to think about how this mechanism apeard on earth and evolved, it seems a very patient engineer just configred all these stuffs and tested them and optimized them.
A few years ago after i learned all of these, i said to my self if someone solve the protein fold problem, a boom of research and development would initiate, and here we are with alphafold, every day i see some paper that they discovered something new with this technology
New to your work guys and am blown away by the depth of understanding to present such sophisticated visual aids. Really happy and less despair in this information age that you guys rally the diligent and dedicated to show the evidence in terms comprehensible by many. Australians as a very good axample rather than cringeworthy underdone blowhards. You save lives, 54 years old and lost for life stoked by you guys. Not dead yet .. all eyes and ears. Cheers, Damo
Thanx. It’s been a deep dive on TH-cam couple of off days. I watched the history of civilization, all the wars and destruction. Then I watched a couple of physics videos, I know if I keep at it I’ll get it! 🤣🤣🤣 And then I found you guys!
This is pure scientific gold! Thank you so much. I am a science dad too and I used your videos with my kids. They just love this! It makes them and me ask so many interesting questions❤. A game for VR wpuld be more than awesome! I imagine to look at labeled or highlighted levels of abstraction or focus like in your videos, all in a loop to explore all the reactions. A time zoom to watch true brownian motion would be the cherry on top.
These molecular biological animations are so just blowing! Awesome work Drew and Team. Thank you!
Incredibly valuable work which has greatly enriched the learning and understanding of my high school students, I look forward to seeing this in VR; and why not have a video game too!!?
Merry Christmas Drew - thanks for your fantastic work. Do you have a Patreon account?
Thanks so much for taking the time to share your CAD/animation tooling and workflows.
Wonderful masterpiece!!! Thank 3.000 to Drew Berry and to all the collaborators!!!
Your animations have amazed and astounded me for many years. Thank you deeply, Drew.
Many of the inner workings of our bodies are no longer unimaginable, and in fact, are extremely beautiful.
thankyou so much for your art! i love it. i also loved my amiga.
Thank you for your work. It helps young molecular biologists like myself who need to construct a visual model of transcription pathways and protein complexes in their head to get a good grasp of it and to entice and compell people outside the field who struggle with just facts and figures
This video touches on so many professions, technologies & disciplines. I am an Industrial Designer; the science, information & technology shared in this video is supremely applicable to my industry. Please keep on your mission of information sharing & science education.
Thank you for your time and veracity in this journey you've taken, Berry! Great to see more recent uploads while soon to complete an AS in chemistry while transferring to university for biochem. Thanks again!! ⭐
1:55 omg, i used to play that game as a kid. I literally had to hack the game files(on PC) - copying the files from a previous level to haphazardly replace the CORRUPT final level files - to even be able to play the final level of this game (otherwise it would never complete loading!). I only learned to do that after a number of years too, some of my first experience fixing PC software problems, stay at it kids & come back to old problems! 😉
Great work. Known your work for a few years, but this video allowed me to get to know you a little. Thank you. Inspirational.
太酷了,這樣視覺化學習很容易理解神奇複雜細胞運作?" 美極了,由衷感謝! So cool! Visualization is more easier to help us to learn the amazing complexity of cell operation. Great! Thank you all.
Incredible job. Your animations are really showing how beautyful the life and science can be.
It's incredible, it's all the questions I had in high school in one animation.
Honestly, the first time I ever saw an animation similar to this (it was likely based off your work or might actually have _been_ yours) that showcased how the mitochondria powers the cell with these tiny little rotors spinning, it absolutely blew my mind. I couldn't help but make the comparison with how _we_ make power for our human-scale use. The molecular machinery literally looks and seemingly acts just like the steam turbines of power stations, or water turbines of hydro-electric dams. And here we humans thought _we_ invented this method first ... turns out nature _just_ beat us by, oh about 1.45 _billion_ years or so LOL
Amazing work … so happy that I had chance to listen to your incredible skills. Many thanks 🙏
Love you and your team Mr. Barry. You guys are awesome. The videos are always mind blowing. ❤️
Phantastic to see these moleculs in action.
Anyone know more animators/channels that make videos like this? I want more molecular biology animations that depict Brownian Motion, with molecules modeled by atoms instead of electron surface.
It's nice to see the inside of a mitochondrion; I am more interested to see the inner workings of free living or parasitic prokaryotes.
Love this stuff! So mind blowing to get to see the process. Thank you!!!!
Belfast Ireland 🇮🇪
So grateful for Drews Work
Unbelievable
For all of us
Great work! Thank you for the insight in your workflow. The integration of game engines is a (...wait for it...) game changer ;-) and I'd love to hear more about this!
The last animation of the giant enzyme complex looked very confusing to look at, at first, my brain felt like it saw a 3D structure, but didn't know how to interpret it. Then, just before the video ended, the shapes started to form in my vision. Alas, then the video was done. I would have liked it to have lasted a bit longer and wandering around it, zooming in and out, to give the mind the occasion to interpret what it is looking at. I myself have done some sculpting. And from African sculptures I have learnt that African artists have a much greater awareness of 3D possibilities, unlike Western art, that focuses more on surfaces, African art plays with spatial relations. Maybe a hint to get Africans involved in research and interpretation and creation of complicated 3D-spatial structures, as for them it seems like a game.
Just amazing artistry. Bdellovibrio would be proud. Thank you!
I love these animations of how these Protein Machines actually work. They are amazing.
So you're animation is an accurate depiction of what it really looks like
Thank you so much
You guys have helped me excell in my knowledge of the Cells
I think Dyslexic people will get the Cells
We think in puzzles
I never thought in a million years
I would get Cellular Biology....thanks guys
Belfast Ireland 🇮🇪
Nooooo, the réal Drew Berry??? :o You're my legend... Science has always been my big passion, and because of you I'm really fascinated by animation.. But I haven't found any project yet to practice both together...
Thank you Drew, that has answered many questions I have had over the years and we have got to know you better.
Keep up the good work.
Buddy you are so awesome , you are helping to pioneer a new way of learning.Keep up the "Excellent Work!"
40 minutes video just went by like 5 min. So amazing!
Drew Berry, you are an inspiration to me
Congratulations on an amazing compilation of the science and art. Keep up your good work.
David Vine , DDS, Miami Beach, .
Yes i´ve been in architectural Compter visualisation for years... but this was realy awsome..
Understands the nature of what he depicts miraculously. He is a true Michelangelo of our time.
If I could make a wish, I would like to see a short movie of a fish being eaten, digested, build in and respirated.
Many thanks for the insightful info! Your videos keep inspiring me to try something similar and I wondered how would simulating the Brownian motion work. Never thought of using a game engine, great idea!
I am just so much in love with your work...it's amazing
Love your work... Taught me how DNA, mRNA and Epigenetics works.
Those molecular dynamics simulations are very nice. However, besides the length scales shown on the simulations, it will be very nice if they could also have the time scale shown as well.
Thank you for your introduction! And keep up the nice work! 👍
Very nice sir 🙏
This is mind-blowing! Thank you for making these!
Brilliant.
PDH complex is the most astonishing enzyme. I would suggest to design animation for hemoglobin binding and releasing molecular oxygen with the conformational changes of oxy- and deoxy- Hb. Needles to say with the role of heme prosthetic group.
Thank you.
Haemoglobin and Sickle Cell Anaemia animation, originally created 20 years ago. Not as advanced as our recent productions th-cam.com/video/-1_qkwQkB_c/w-d-xo.htmlsi=jSMaR0pxmKk-GKCi
ur the best ....belfast ireland
thank u so much
You called yourself a "dinosaur" because you learned techniques in the 90's...
I attended a talk given by James Blin, a pioneer in animation who worked on the famous "Mechanical Universe" series. He wrote them in FORTRAN.
Absolutely amazing!
Bravo, Drew!
Stupendous.
Thank you for all your hard work.
Thanks a lot for all you doing!
Why DO the molecules go to where they're supposed to go? Do they move by random diffusion, or is their motion powered?
Love your work, thanks so much.
Amazing work! Thanks for sharing!
thx for your work .
Remember memorizing the Krebs/ Citric Acid cycle out of photocopied pages in a binder your Professor made you buy at the college bookstore for $100? Now the kids these days have this! I'm happy for the new generation though, they have more information presented in an understandable,visual learning format!
Im so impressed by this animation
Very impressive, mate. Good work.
Genius, mind blowing, tausend thanks
Perfect job. Great work. Amazing videos. Like 👍🤗
Fascinating. Thanks
wonderful...
Great work. I loved molecular animation.
This is educational gold!
Good job! Congrats.
Great work from a famous name in graphics.
This is beautiful.
Thank you,good video
Great work 👍
So wonderful!
Nice work 👍
How those molecules which form the ATP molecule know where to go to become ATP? It was mentioned in the animation "enzymes bring together reactants", but nothing more. How smooth is this process in reality? Like each cycle of the rotor creates exactly 3 molecules each time?
See 22:04 for a "real" animation and his explanation of artistic license.
@@JohnDlugosz I see, I made it to 20:00 minutes I thought I'd finish it today. Thanks.
"no one can make cool stuff about biology"
drew barry:
Amazing, amazing, amazing ...
Oh my god it’s Drew Berry!!
very good animation.
I can only say thank you. thank you
This was excellent!! -maya animator
Brilliant!
Wow... While i still don´t understand why you call Maya a game engine, i understand that the animations skillset of maya is on blockbusterlevel..
But do you also use tools like Unreal for the "REaltime" Part?
it´s realy mesmerising.. If i was young again, this could be something for me to study too.. But now as my son studies something like this, i know how much you have to learn to get there
The real-time game engine we use for production is Unity
1:54 Bitmap brothers!!
#Cool 💖😊
Incredible
never has 37mins seemed so short
I agree! Wish it had Drew show us a version of the more chaotic looking realistic movements, timing, and density of the individual components. He and his team do a phenomenal job of interpreting and rendering the complexities of what makes life possible. Absolutely fascinating and wondrous! ❤
WOW!