these excellent videos remind me of my first course in quantum mechanics where the teacher put up a slide with the following statement:(paraphrasing videos for articles) The videos are are hard to understand ;perhaps they were harder to make!
This is insane. 20 years ago, when I was in school, chemistry and biology were such weird and difficult to understand subjects. But today, with the knowledge, plus the possibility of visual examples and explanations, everything is much more clear, and easier to grasp. Now I am interested in botany and Plant tissue culture. These types of videos help a lot. The human body is also really interesting to learn about this way.
@@agustinbarquero8898From a GenX POV, some of this information wasn't yet known. The information that was known was accessed by physically going to a university library, searching the in the card catalog, finding the book/magazine/microfiche/vhs/floppy disk for one specified subject. It just wasn't easy to get, let alone whether or not it existed.
Explained so even a mechanical engineer understands it! The biological programming is just mind blowing, not to mention the machines the programs are building. That the failure rate (illnesses) are not more frequent also is just fantastic. Well done 🤙
Actually the error rate is higher than you might think! Modern cells have a lot of systems in them that tidy up these issues. A good example is how often our skin cells are bombarded with ionizing radiation, shredding our DNA like a shotgun blast. We also have free radicals in our systems, which can cause similar damage, and our bodies produce those naturally. Heat and viruses can also cause damage. There are a couple ways the DNA can get repaired. In many cases, whatever split the DNA can just be joined back together. Since this generally only occurs in one of the four nucleotides, it doesn't need to figure out which one it is. In other cases, only one half of the helix is damaged, and the other half can be used as a template to "rebuild" that section. There are some methods the cell has for both sides of the helix breaking, but they're kinda iffy on whether they work or not. The whole process is quite fascinating. Not to say I'm a professional by any means, I was reading a lot of this off of wikipedia, but it's still very cool to learn about c:
@@eatshitlarrypage.3319 The body has several mechanisms to repair DNA that may have been damaged in multiple ways. It's fascinating the things our cells can do. Even with the errors that can happen OP was right about the failure rate of these mechanisms. While it may seem like there are lots of cases of failure, the rates drop when you realize just how many times the mechanisms work compared to how many times they fail. I know I'm going off, but I love biology from the bottom of my heart and being able to share what I learn. Regardless, our bodies are miracles in every way.
How is an engine built , a spacecraft ect ect..so complex . We ,human beings are the most complex creatures on this planet along with millions of other species of animals and incects all complex creatures as well. How then were we all created? Think about that one. We were created by God with infinite intelligence ❤
@@agustinbarquero8898 Yeah, wave some creds ---- but not a degree. At MINIMUM, having a single peptide chain is a chemical/mathematical miracle, textbook definition. Study a lot longer.
A million thanks from the bottom of my heart for all who worked behind every tiny bit of this topic. starting from the amazing geniuses who worked it in thier heads to the ones who spent thier time creating a visual representation of the discovery and finally the ones who decided to put it all together and share it for all who have access to INTERNET !! If only I watched it during my college days!!!! Well better late than never !! Once again.. Thanks a gazillion trillion tons !
So who created the creator? LOL. If you believe in a god, then you must confront the problem of the origin of the very FIRST god. He could not simply have come into existence. Since he could not have been created, he must have evolved. So...if a god can evolve, so can anybody else. Biology is complex as you can imagine, and more so, but it's that way due to billions of years of EVOLUTION of the processes that make it. Not due to some mythical deity snapping his fingers, thus eliminating any need for you to attempt to engage your tiny little brain and understand the wonders of biology for yourself.
this mechanism works on very simple and basic laws of physic. our body's are messy and honestly quite foolish from an engineering point of view. if an actual creator really exist, i would gladly spit into his stupid face for giving us our spine and one hole for breathing/eating and pissing/procreating. those are the most obvious examples, but if you strain your brain for like 5 minutes and think about; why we still have fingers on our feet and why the hell do those have fingernails? why can we only see 3 prime colors? why do we have exactly the same amount of hairs on our body as primates do?(ours is just less visible) ... we're apes, bro. Apes, who, historically speaking, climbed down from trees, like... yesterday. And our stupid biology proves it by itself.
It is a very common error to see something that is the result of a non random process and assume that it must have had intelligence behind it. There many examples of processes in nature that are non random that are not due to intelligence. Can you think of non random process in nature that is different than evolution by natural selection?
@@Turboy65 The solution is not in the number of years Thousands or billions of years make no difference Because the process of cell formation is not only random interactions with each other Rather, it is a complex, orderly, and sequential process Billions of years can't solve this problem For example, the phone, collect its components and put them in one place for hundreds of years Can the components of the phone arrange themselves and configure the phone without human intervention
@@ammertyantey714 Biology is different than mechanically manufactured items because of the self-organizing properties of the critical organic compounds. It can be said that those organic compounds have a unique counter-entropic force within them. But they're still not the product of your mythical god.
This is the best animation on the topic I've seen. I've watched a number of similar videos recently, always feeling afterwards that my knowledge was still fragmented. This one has painted the full picture for me. Thanks so much for using your talents to help us all learn! 👍💐
I always find the comments on videos like these fascinating. These are all of the same diagrams that were in Freshmen Biology textbooks I used in high school, just animated. I watch them now as an adult and think they're nothing special, but so many people comment on how seeing it in motion makes all the difference in being able to understand and engage with it. I've always been the same way, but about mathematical concepts - I can look at numbers on a page and it's all gibberish until I see the concepts applied to a live example, but some people can easily visualize complex math concepts purely in their mind without effort. It's truly incredible how differently people's minds work!
I like how different parts of the video are like episodes of a show where a new character is introduced in each to further the plot and to explain other things that came before
Had there been such animated videos 35 yrs back I would have been a super scientist 😊 Sadly, I never had these and every time my teachers walked into a classroom to teach they either spit from a textbook or bluntly pretend to outsmart us, not knowing what they are teaching /talking! All I knew was they made most of us yawn in class. And to make it worse 90% of the biology classes were after lunch which is the time we are in food coma. Importance were given not in understanding but writing pages after pages and that too with color diagrams like you should be a super good student who can be all in all! OMG if those diagrams did not meet up to their expectations I am a dead rat. Old days yet fun to recall them now!!! Anyways, glad to know at least my kids will benefit today and I have to admit I am understanding my high school subjects more clearly now when I am watching these and teaching my kids including English grammar!!! 😬 adjective, adverb, pronoun, noun...
Amazing edit sequence, i noticed you used repetition and new approaches in each segment to help solidify the idea. great job. i feel like i downloaded the info directly into my head lol
You can’t watch this and not be in complete awe of how perfectly intricate and precise your body is. And yes, my brain cannot believe that this system just formed itself out of nothing. I’m not religious at all, but I cannot fathom how this can be explained as random.
@NothingToSeeHere google picks up on noises from your phone and thus recommends anything from advertisements to route suggestions to video recommendations and dining choices in your area.
I am mesmerized 🤩 this video is the most accurate I have ever seen. Now, everything I have ever read/seen about protein synthesis makes sense in such a beautiful manner.
Genetics always sent over my head. Thank god i found these videos on time. I could never learn this much from my teachers in a year than i did from this 20 minute video. Thank you so much.
The fourth video... My AP biology teacher in high school showed us this in class and it was so fascinating and helpful. Now I'm in college taking Anatomy & Physiology 1 and studying for my protein synthesis quiz. I try not to remember much of high school, but I remember very distinctly learning about DNA and RNA in her class and all the worksheets she gave us to help us grasp the concepts. I'm super thankful for that now! Revisiting these topics has been a lot easier
Imagine Gen-Xer's like myself. We had pictures and had to apply those pictures to the written and oral information to "imagine" on our own... on top of that, some of the informatiin in these videos wasn't known, let alone easily accessible. My mind is blown
Esto es asombroso! En tanto tiempo me enseñaron todo esto por separado y nunca llevaba una secuencia para mí, el vídeo me ayudó a comprender todo el conocimiento que estuvo guardando y jamás entendí por completo, muchísimas gracias!
Please make a detailed video on protein maturation and secretion........ As your videos are really good and clears my doubts so smoothly.......i'm hoping it will do the same for this topic too
The elegance of the biologic machinery only increases as you go depper in detail. For example how does the mrna not fold on itself while exiting the nucleus? How does it exit the nucleus, transported or by chance? How does a ribosome know that the mrna is currently occupied by another ribosome? How does the small ribosome unit read the base sequence and find the start codon, if it binds to the "spine" of the mrna? How does a trna molecule "know" not to bind to mrna until a ribosome is present? How does the ribosome power its own movement on the mrna, and go in the right direction? Do trna enter the ribosome by chance/brownian motion alone? Where do non coding mrna segments end up? How does the cell know when a mrna segment is spent? Can the ribosome detect errors on the mrna strand, and how does it behave if an error is found?
WOW!. kkkk oh shit this is crazy kkkkkk and, hey, i just want to you to know that those questions shows how a cientist think. A good cientist think just like you. more questions, more knowledge. congrats
Phenomenal explanation!! Everything was explained so clear with the added repetition. It’s bothers me a lot that all of this happens at a molecular level and our body, cells, and DNA has all it needs to help us live. But what was going thru my mind was this process resembles how computer science works. A step-by-step process that looks for activation/termination blocks. The codon, tRNA, Ribosomal portion blew my mind. (The translation stage)
When you train your brain, with time it will start to add so many complex numbers. Your body works so hard because you gave it training e. g. exercise... with all due respect, the protein synthesis of sick or bed ridden people do not work as yours because another bunch of organelles (e.g. mitochondria) cannot manufacture the energy (ATP) to work like yours, and they break down; just like your brain stops when it cannot go further doing addition...btw, I can do that addition in less than a second not because I'm a superman, but because it took me years to train cells of my memory organ (the brain) if i stop training, i will also lose that ability... if only everybody knows this, we won't destroy this complex and wonderful machines call BODY
Some 40 years ago I had a talk with a biochemist. We did not talk about protein synthesis. We talked and the capabilities of nature and humans. The question came up What did humans invent that was not invented by nature already. She mentioned the zipper. Here we see that the zipper in a much more complicated way was invented by nature some billion years, of course for different purpose. This video contains very good animations. It does not expain everything, for example, how the cell is informed that it has to produce a certain protein. Overall, this video is information and education at a high level.
I have watched several videos regarding translation process but failed to understand but after watching your videos I can understand it very easily tysm😊😊😊😊
Great explanation along with amazing visuals, Although I do have one question id like to ask. What is the speed/clock rate at which these proteins are synthesized?? Like how fast would this process be if we where to watch the process take place on our human time scales?? Like a *proteins per second* type of thing.
And another interesting question is what kind of concentrations of tRNA would be required to have the synthesis happen in a reasonable amount of time. The videos are deceptive since it looks like the tRNA molecules are like little self driving Teslas with GPS guidance leading them right into the A site. In reality however, due to Brownian motion, everything is jiggling like mad inside that cell. It is absolute chaos. A tRNA with the wrong codon would be much more likely to enter the A site than would the correct tRNA. So the wrong tRNA would have to jiggle itself into the A site and then realize that it is not binding to the mRNA and then it would have to jiggle out of the A site and then, eventually, the correct tRNA would jiggle in and bind to the codon and do its thing. So you are not left waiting an eternity for the right one to jiggle in, it seems like the space around the ribosome must almost pure tRNA to get them to jiggle into the A site and see if it is a match and then jiggle out if its not a match. Its a miracle anything works at all in such an environment!!
Solid Absolute gddamn Win of a video! I only learned this stuff on my lonesomes, so having a visualisation to go with the concepts in my head is greatly appreciated. The blessing of Jah upon you
Thank you so much for this amazing video. Although I'm rewatching this many times, i have not commented my appreciation. I'm just a normal person who is very curious about everything and how it works. Watching this kinda videos gives me different kind of high and a feel of wonder
عرض غاية في الفائدة و المتعة و البساطة نتمنى من اي جهة ان تتبنى دبلجة هذا الفيديو الى اللغة العربية لتسهيل شرح هذه الآلية و هذه المعجزة الالهية التي تحدث في اجسامنا في كل لحظة
Tell me why I got the most profound sense of relief watching this? The last section in particular visualizes protein synthesis in a way that feels so true to life its scary. You’re basically watching a stunning reproduction of the most basic engine of life. Little RNA strands ticking along through ribosomes. Automatically? What moves this cycle?
The Hand of God. At some point, we will understand the scientific processes in even greater detail, but at the bottom of it all, the prime mover is the Hand of God
Anyone care to explain how natural selection creates this incredibly sophisticated machinery and software? Amazing job by the team that created this video. Great work!!!
most likely old earth was capable of forming simple self-replicating machines out of its own goop floating in its ocean. of course machines that were better at not getting destroyed and making more of themselves survived and those that didn't died out, much like the living creatures of today. and through natural selection this amounted to early, shitty cells & then us.
How it occurred matters less than the reality that it has been going on in every living thing hundreds of millions of years before humans. Because it occurred, you can now begin to understand how amazing it is. We will never know how. How did the big bang happen. Why do electrons associate with the nucleus of an atom?
Just watched BBC’s First Life w/ David Attenborough and they talked about the conditions on early Earth that led to the evolution of the first single cell organisms and I had the realization that there was a time where no living cells existed on Earth and then there were. The fact that some wild combination of atoms and sunlight tangled together in such a way that has led to the diversity of life we’ve seen on our little planet is unbelievable and profoundly awe inspiring. Then I started digging and learned about “RNA world” which is a hypothesis that maybe there was a period where “self replicating” RNA molecules proliferated Earth before the formation of cells. I’m curious what forces led to the synthesis of those molecules. Feels like the Universe just kept whipping matter until life sprang. First gravity pulled our planet together. Then it found a star or maybe before and started spinning. Then water churned and molecules formed and swirled and interlocked and broke apart for billions of years until cells formed and spun themselves into animal machines of all shapes and abilities. Plants root into the soil and make energy with the light that started it all. And to think these little molecular protein printers are churning out the blueprints for all of this complexity by sheer chance is truly head cracking stuff. Not me Wellbutrin ranting in the comments section of an educational science video!
Thank you very much!I got a better knowledge of protein synthesis more than what I had learnt.It really helped me to understand the process well.THANK YOU VERY MUCH🙏💖
We are fearfully and wonderfully made! How is it pompous man has jumped to the conclusion these highly complex and interrelated processes just evolved out of random chance?
11:30. So, you have exons and introns. I'm a software engineer and I need to ensure that data is valid when transmission occurs between locations. This is primarily accomplished using Cyclic Redundancy Code (i.e. CRC). Question, do the introns ack as data verification of the exons?
Certain sets of exons code for "data verification" enzymes that correct errors that occur during replication. Introns are mainly promoters and repressors, which can be activated or repressed themselves by certain enzymes, which dictate whether the following gene (which could be an intron or an exon) should be read or not. They sort of become one big clusterfuck of logic gates in that sense.
Really it is a great explanation about translation with a great animation. I am also a lecturere I just want to know how to make it, which software is used to make it?
This best best animated video. I am microbiologist. This video very very easily to understand. I love ❤😍🌹it . understood very well. 👌👌👌keep it like this. It's very useful. Understood protein synthesis.
The process itself is too wonderful to understand .... that I & you are made of these things, that they are happening trillions of times per second ...
RNA Polymerase Introns/Extrons Spliceosomes mRNA Aminoacyl tRNA synthase pyrophosphate Amino Acid+tRNA+ATP AUG Initiation Methionine Ribosome small and large Subunits A site, P site, E site Release Factor Initiation, Elongation, Termination Polypeptide Endoplasmic Reticulum Golgi apparatus
I’m having 40 years teaching experience behind me but I loved the video. It’s one of the best animated material of its kind.
agreed. but can you tell me how did scientist uncover this?
these excellent videos remind me of my first course in quantum mechanics where the teacher put up a slide with the following statement:(paraphrasing videos for articles)
The videos are are hard to understand ;perhaps they were harder to make!
Yeap, that's right, I always use the first one (I'm a biology tutor), but the next three (2,3,4) videos are good too!!
@@baynessagneberhe9700 yeah I also wanna know the same thing..
Nice work
This is insane.
20 years ago, when I was in school, chemistry and biology were such weird and difficult to understand subjects.
But today, with the knowledge, plus the possibility of visual examples and explanations, everything is much more clear, and easier to grasp.
Now I am interested in botany and Plant tissue culture. These types of videos help a lot.
The human body is also really interesting to learn about this way.
Oh, you are so smart, please, tell me more about your very interesting hobbies
Its been decade of hard work of independent scientific communities. It seems easy but previously it was difficult to decode.
What's "insane" about it?
Yes!! My mind is blown and curiosity reignited!! We had to "imagine" this complex info on our own🎉🎉
@@agustinbarquero8898From a GenX POV, some of this information wasn't yet known. The information that was known was accessed by physically going to a university library, searching the in the card catalog, finding the book/magazine/microfiche/vhs/floppy disk for one specified subject. It just wasn't easy to get, let alone whether or not it existed.
Explained so even a mechanical engineer understands it! The biological programming is just mind blowing, not to mention the machines the programs are building. That the failure rate (illnesses) are not more frequent also is just fantastic. Well done 🤙
Actually the error rate is higher than you might think! Modern cells have a lot of systems in them that tidy up these issues. A good example is how often our skin cells are bombarded with ionizing radiation, shredding our DNA like a shotgun blast. We also have free radicals in our systems, which can cause similar damage, and our bodies produce those naturally. Heat and viruses can also cause damage.
There are a couple ways the DNA can get repaired. In many cases, whatever split the DNA can just be joined back together. Since this generally only occurs in one of the four nucleotides, it doesn't need to figure out which one it is. In other cases, only one half of the helix is damaged, and the other half can be used as a template to "rebuild" that section. There are some methods the cell has for both sides of the helix breaking, but they're kinda iffy on whether they work or not.
The whole process is quite fascinating. Not to say I'm a professional by any means, I was reading a lot of this off of wikipedia, but it's still very cool to learn about c:
@@eatshitlarrypage.3319 The body has several mechanisms to repair DNA that may have been damaged in multiple ways. It's fascinating the things our cells can do. Even with the errors that can happen OP was right about the failure rate of these mechanisms. While it may seem like there are lots of cases of failure, the rates drop when you realize just how many times the mechanisms work compared to how many times they fail. I know I'm going off, but I love biology from the bottom of my heart and being able to share what I learn. Regardless, our bodies are miracles in every way.
@@iamagirl9938Not really. As someone who studied molecular biology, I can say other bodies are far from miracles.
How is an engine built , a spacecraft ect ect..so complex . We ,human beings are the most complex creatures on this planet along with millions of other species of animals and incects all complex creatures as well. How then were we all created? Think about that one. We were created by God with infinite intelligence ❤
@@agustinbarquero8898 Yeah, wave some creds ---- but not a degree.
At MINIMUM, having a single peptide chain is a chemical/mathematical miracle, textbook definition. Study a lot longer.
finally i found the detailed and satisified video about protein synthesis....thank you so much..
A million thanks from the bottom of my heart for all who worked behind every tiny bit of this topic. starting from the amazing geniuses who worked it in thier heads to the ones who spent thier time creating a visual representation of the discovery and finally the ones who decided to put it all together and share it for all who have access to INTERNET !!
If only I watched it during my college days!!!!
Well better late than never !!
Once again..
Thanks a gazillion trillion tons !
Yes. I feel the same - grateful. It's utterly incredible.... glorious ...
2:58
The most detailed explanation ! You'll want to watch this part twice!
Yes..the best among all and also very much in accordance with class 12 biology chapter molecular basis of inheritance.
It's even very summarized in the video
Yeah except it skips the first part - the creation of mRNA.
Its insane!!
I cant understand how could people not believe there is a great creator behind this mechanism of our bodies !
So who created the creator? LOL. If you believe in a god, then you must confront the problem of the origin of the very FIRST god. He could not simply have come into existence. Since he could not have been created, he must have evolved. So...if a god can evolve, so can anybody else. Biology is complex as you can imagine, and more so, but it's that way due to billions of years of EVOLUTION of the processes that make it. Not due to some mythical deity snapping his fingers, thus eliminating any need for you to attempt to engage your tiny little brain and understand the wonders of biology for yourself.
this mechanism works on very simple and basic laws of physic. our body's are messy and honestly quite foolish from an engineering point of view.
if an actual creator really exist, i would gladly spit into his stupid face for giving us our spine and one hole for breathing/eating and pissing/procreating.
those are the most obvious examples, but if you strain your brain for like 5 minutes and think about;
why we still have fingers on our feet and why the hell do those have fingernails?
why can we only see 3 prime colors?
why do we have exactly the same amount of hairs on our body as primates do?(ours is just less visible)
...
we're apes, bro.
Apes, who, historically speaking, climbed down from trees, like... yesterday. And our stupid biology proves it by itself.
It is a very common error to see something that is the result of a non random process and assume that it must have had intelligence behind it. There many examples of processes in nature that are non random that are not due to intelligence. Can you think of non random process in nature that is different than evolution by natural selection?
@@Turboy65
The solution is not in the number of years
Thousands or billions of years make no difference
Because the process of cell formation is not only random interactions with each other
Rather, it is a complex, orderly, and sequential process
Billions of years can't solve this problem
For example, the phone, collect its components and put them in one place for hundreds of years
Can the components of the phone arrange themselves and configure the phone without human intervention
@@ammertyantey714 Biology is different than mechanically manufactured items because of the self-organizing properties of the critical organic compounds. It can be said that those organic compounds have a unique counter-entropic force within them. But they're still not the product of your mythical god.
This is the best animation on the topic I've seen. I've watched a number of similar videos recently, always feeling afterwards that my knowledge was still fragmented. This one has painted the full picture for me. Thanks so much for using your talents to help us all learn! 👍💐
00:00 - first video
2:58 - second video
8:43 - third video
16:03 - fourth video
Thanks!
I always find the comments on videos like these fascinating. These are all of the same diagrams that were in Freshmen Biology textbooks I used in high school, just animated. I watch them now as an adult and think they're nothing special, but so many people comment on how seeing it in motion makes all the difference in being able to understand and engage with it. I've always been the same way, but about mathematical concepts - I can look at numbers on a page and it's all gibberish until I see the concepts applied to a live example, but some people can easily visualize complex math concepts purely in their mind without effort.
It's truly incredible how differently people's minds work!
I like how different parts of the video are like episodes of a show where a new character is introduced in each to further the plot and to explain other things that came before
Haha true tho.
XD
Had there been such animated videos 35 yrs back I would have been a super scientist 😊 Sadly, I never had these and every time my teachers walked into a classroom to teach they either spit from a textbook or bluntly pretend to outsmart us, not knowing what they are teaching /talking! All I knew was they made most of us yawn in class. And to make it worse 90% of the biology classes were after lunch which is the time we are in food coma. Importance were given not in understanding but writing pages after pages and that too with color diagrams like you should be a super good student who can be all in all! OMG if those diagrams did not meet up to their expectations I am a dead rat. Old days yet fun to recall them now!!! Anyways, glad to know at least my kids will benefit today and I have to admit I am understanding my high school subjects more clearly now when I am watching these and teaching my kids including English grammar!!! 😬 adjective, adverb, pronoun, noun...
For someone who attented university 40 years back, this video is an updated refresher course. Thnx so much.
Any conceptual changes since then?
Amazing edit sequence, i noticed you used repetition and new approaches in each segment to help solidify the idea. great job. i feel like i downloaded the info directly into my head lol
Ppl
Mind.... blown!!! The fact that this is happening in our bodies but at the speed as well. So many types of cells... All of it. Just a mind blow!
Absolutely incredible. A miraculous achievement, and a gift to be the inheritors of such beautiful work.
This video just blew my mind 🤯! The animation made it *VERY* easy to understand the process. Thank you so much for this
You can’t watch this and not be in complete awe of how perfectly intricate and precise your body is. And yes, my brain cannot believe that this system just formed itself out of nothing. I’m not religious at all, but I cannot fathom how this can be explained as random.
I was literally procrastinating finishing an assignment on exactly this. How did TH-cam know o.O
@NothingToSeeHere google picks up on noises from your phone and thus recommends anything from advertisements to route suggestions to video recommendations and dining choices in your area.
@@miguelmejia4656 must have heard "bloody ribosomes!!"
This comment section 🤣🤣
@@Dioptreskillz ha ha ha!!
I am mesmerized 🤩 this video is the most accurate I have ever seen. Now, everything I have ever read/seen about protein synthesis makes sense in such a beautiful manner.
Every biology student will appreciate this and love this video so much, thank you really ❤
Genetics always sent over my head. Thank god i found these videos on time. I could never learn this much from my teachers in a year than i did from this 20 minute video. Thank you so much.
I have a test tomorrow and I can’t be thankful enough , this has helped me a great deal
I don't want youtube educated doctors to prescribe medication
The fourth video... My AP biology teacher in high school showed us this in class and it was so fascinating and helpful. Now I'm in college taking Anatomy & Physiology 1 and studying for my protein synthesis quiz. I try not to remember much of high school, but I remember very distinctly learning about DNA and RNA in her class and all the worksheets she gave us to help us grasp the concepts. I'm super thankful for that now! Revisiting these topics has been a lot easier
I longed for these videos when I was a student. That was 10 years ago.
Imagine Gen-Xer's like myself. We had pictures and had to apply those pictures to the written and oral information to "imagine" on our own... on top of that, some of the informatiin in these videos wasn't known, let alone easily accessible. My mind is blown
@@blue4democracy omg ıt must be so hard. :(
Wow, it continuously boggles my mind how amazingly complex life is. Each cell is like some hyper advanced crazy 3d printer of proteins.
Esto es asombroso! En tanto tiempo me enseñaron todo esto por separado y nunca llevaba una secuencia para mí, el vídeo me ayudó a comprender todo el conocimiento que estuvo guardando y jamás entendí por completo, muchísimas gracias!
The fact that scientists have worked this out is extra ordinary
Very nice animation! (Detail: The aa should be attached to the 3'-end of the t-RNA, not the 5'-end.)
finally found a good video to understand protein synthesis, to understand better read about protein synthesis then watch it ❤❤
Psalm 139:14
I praise you because I am fearfully and wonderfully made; your works are wonderful, I know that full well.
God didn't create this
This Bible verse beautifully describes the small complexities of nature.
It’s hard to learn about protein synthesis when the animation of it is so beautiful ngl.
Please make a detailed video on protein maturation and secretion........ As your videos are really good and clears my doubts so smoothly.......i'm hoping it will do the same for this topic too
The elegance of the biologic machinery only increases as you go depper in detail.
For example how does the mrna not fold on itself while exiting the nucleus?
How does it exit the nucleus, transported or by chance?
How does a ribosome know that the mrna is currently occupied by another ribosome?
How does the small ribosome unit read the base sequence and find the start codon, if it binds to the "spine" of the mrna?
How does a trna molecule "know" not to bind to mrna until a ribosome is present?
How does the ribosome power its own movement on the mrna, and go in the right direction?
Do trna enter the ribosome by chance/brownian motion alone?
Where do non coding mrna segments end up?
How does the cell know when a mrna segment is spent?
Can the ribosome detect errors on the mrna strand, and how does it behave if an error is found?
WOW!. kkkk oh shit this is crazy kkkkkk and, hey, i just want to you to know that those questions shows how a cientist think. A good cientist think just like you. more questions, more knowledge. congrats
I got my Goosebumps on studying all these processes these are just 😊
Phenomenal explanation!! Everything was explained so clear with the added repetition.
It’s bothers me a lot that all of this happens at a molecular level and our body, cells, and DNA has all it needs to help us live.
But what was going thru my mind was this process resembles how computer science works. A step-by-step process that looks for activation/termination blocks. The codon, tRNA, Ribosomal portion blew my mind. (The translation stage)
My body does so tideous work regularily without fail and still i sweat while adding 23 to 58
Haha lol. Ikr.. Never knew my body was so hardworking
^^
When you train your brain, with time it will start to add so many complex numbers. Your body works so hard because you gave it training e. g. exercise... with all due respect, the protein synthesis of sick or bed ridden people do not work as yours because another bunch of organelles (e.g. mitochondria) cannot manufacture the energy (ATP) to work like yours, and they break down; just like your brain stops when it cannot go further doing addition...btw, I can do that addition in less than a second not because I'm a superman, but because it took me years to train cells of my memory organ (the brain) if i stop training, i will also lose that ability... if only everybody knows this, we won't destroy this complex and wonderful machines call BODY
Right?! I'd like to see animations to simplify mathematics!!
Sounds like your not trying hard enough. Math is easy get good.
This is the best video on this planet for protein synthesis topic.
There must undoubtedly be a Creator for these wonderful and complex things
Life exhibits an exquisite molecular choregraphy and impeccable timing.
Glorious!
What a wonderful Creator we have. Thank you for sharing this
It is world most best animated video of protein synthesis. Keep it up
These type of 3d explained topic is just amazing, it clear my all doubt about translation
Thanks😊
Do you mean, to see is to believe?
my whole college days wasn't able to make me clearly understand bout this things, a now, a minute video made it possible or me to understand ❤️
Thank you so much for this concept you have created in animation. This is simply amazing
thx for combining all the best vids for each process. u are the best!!
Some 40 years ago I had a talk with a biochemist. We did not talk about protein synthesis. We talked and the capabilities of nature and humans. The question came up What did humans invent that was not invented by nature already. She mentioned the zipper.
Here we see that the zipper in a much more complicated way was invented by nature some billion years, of course for different purpose.
This video contains very good animations. It does not expain everything, for example, how the cell is informed that it has to produce a certain protein.
Overall, this video is information and education at a high level.
I have watched several videos regarding translation process but failed to understand but after watching your videos I can understand it very easily
tysm😊😊😊😊
Great explanation along with amazing visuals, Although I do have one question id like to ask. What is the speed/clock rate at which these proteins are synthesized?? Like how fast would this process be if we where to watch the process take place on our human time scales??
Like a *proteins per second* type of thing.
It's a few hundred synthesized proteins per second per synthesis unit.
@@Turboy65 thanks for the reply!
@@Turboy65 Nah you are wrong. Depends on a protein it takes far more than that. Single protein takes seconds.
@@brianpj5860 .
And another interesting question is what kind of concentrations of tRNA would be required to have the synthesis happen in a reasonable amount of time. The videos are deceptive since it looks like the tRNA molecules are like little self driving Teslas with GPS guidance leading them right into the A site. In reality however, due to Brownian motion, everything is jiggling like mad inside that cell. It is absolute chaos. A tRNA with the wrong codon would be much more likely to enter the A site than would the correct tRNA. So the wrong tRNA would have to jiggle itself into the A site and then realize that it is not binding to the mRNA and then it would have to jiggle out of the A site and then, eventually, the correct tRNA would jiggle in and bind to the codon and do its thing. So you are not left waiting an eternity for the right one to jiggle in, it seems like the space around the ribosome must almost pure tRNA to get them to jiggle into the A site and see if it is a match and then jiggle out if its not a match. Its a miracle anything works at all in such an environment!!
Very well done. The amazing thing is that this presentation is a very simplified version of what actually happens!
thank you , it has clear all my doubts which might be difficult to understand in a paper.
Solid
Absolute
gddamn Win of a video!
I only learned this stuff on my lonesomes, so having a
visualisation to go with the concepts in my head is greatly appreciated.
The blessing of Jah upon you
the second video is amazing!!!
They know what you are searching on net.....
Wow...I finally found one golden content for understanding the central dogma in detail... 👍🏻 👌 ❤️ 🧬. Such wonderful work~animation!
This video is gold 🤩 for molecular biology students.
Thank you so much for this amazing video. Although I'm rewatching this many times, i have not commented my appreciation. I'm just a normal person who is very curious about everything and how it works. Watching this kinda videos gives me different kind of high and a feel of wonder
Such a complex system, clearly an intelligent design.
Video doesn’t show the details. There is sooo much more.
عرض غاية في الفائدة و المتعة و البساطة
نتمنى من اي جهة ان تتبنى دبلجة هذا الفيديو الى اللغة العربية لتسهيل شرح هذه الآلية و هذه المعجزة الالهية التي تحدث في اجسامنا في كل لحظة
Tell me why I got the most profound sense of relief watching this? The last section in particular visualizes protein synthesis in a way that feels so true to life its scary. You’re basically watching a stunning reproduction of the most basic engine of life. Little RNA strands ticking along through ribosomes. Automatically? What moves this cycle?
If only we have our own microscopes.
The Hand of God. At some point, we will understand the scientific processes in even greater detail, but at the bottom of it all, the prime mover is the Hand of God
I think it's not the Hand of God, it's either the Flying Spaghetti Monster's appendages or the electromagnetic force.
Anyone care to explain how natural selection creates this incredibly sophisticated machinery and software? Amazing job by the team that created this video. Great work!!!
most likely old earth was capable of forming simple self-replicating machines out of its own goop floating in its ocean. of course machines that were better at not getting destroyed and making more of themselves survived and those that didn't died out, much like the living creatures of today. and through natural selection this amounted to early, shitty cells & then us.
How many of you just watched to pass their subjects and how many of you wondered how come this happened by mere chance .
How it occurred matters less than the reality that it has been going on in every living thing hundreds of millions of years before humans. Because it occurred, you can now begin to understand how amazing it is. We will never know how. How did the big bang happen. Why do electrons associate with the nucleus of an atom?
Mere chance. But if I happen to be tested...
Very amazing 😍😍
understanding evolution help to not thinking this is "mere chance"
Just watched BBC’s First Life w/ David Attenborough and they talked about the conditions on early Earth that led to the evolution of the first single cell organisms and I had the realization that there was a time where no living cells existed on Earth and then there were. The fact that some wild combination of atoms and sunlight tangled together in such a way that has led to the diversity of life we’ve seen on our little planet is unbelievable and profoundly awe inspiring. Then I started digging and learned about “RNA world” which is a hypothesis that maybe there was a period where “self replicating” RNA molecules proliferated Earth before the formation of cells. I’m curious what forces led to the synthesis of those molecules. Feels like the Universe just kept whipping matter until life sprang. First gravity pulled our planet together. Then it found a star or maybe before and started spinning. Then water churned and molecules formed and swirled and interlocked and broke apart for billions of years until cells formed and spun themselves into animal machines of all shapes and abilities. Plants root into the soil and make energy with the light that started it all. And to think these little molecular protein printers are churning out the blueprints for all of this complexity by sheer chance is truly head cracking stuff. Not me Wellbutrin ranting in the comments section of an educational science video!
Thank you very much!I got a better knowledge of protein synthesis more than what I had learnt.It really helped me to understand the process well.THANK YOU VERY MUCH🙏💖
This help me alot such a amazing explanation..
We are fearfully and wonderfully made! How is it pompous man has jumped to the conclusion these highly complex and interrelated processes just evolved out of random chance?
Because that's what the evidence supports.
Thank you so much..2nd video is amazing
Now i can understand correctly
Hats off to u.....it's just a next level.... phenomenal video.....that crystal clear my concept in just one go
11:30. So, you have exons and introns. I'm a software engineer and I need to ensure that data is valid when transmission occurs between locations. This is primarily accomplished using Cyclic Redundancy Code (i.e. CRC). Question, do the introns ack as data verification of the exons?
Certain sets of exons code for "data verification" enzymes that correct errors that occur during replication.
Introns are mainly promoters and repressors, which can be activated or repressed themselves by certain enzymes, which dictate whether the following gene (which could be an intron or an exon) should be read or not. They sort of become one big clusterfuck of logic gates in that sense.
This is the best video i have ever seen on translation.... Awsm... 🤩🤩👍🏻👍🏻
Really it is a great explanation about translation with a great animation. I am also a lecturere I just want to know how to make it, which software is used to make it?
This is the best video I have ever seen in my entire life!
Thank you so much for this video, easiest way to understand nice 👌
Third video is highly rich in content. Each every detail is mentioned in it I really loved 3rd video. Others are also good in animation ❤️
It's mental how random evolution resulted in these genetic factories.
This best best animated video. I am microbiologist. This video very very easily to understand. I love ❤😍🌹it . understood very well. 👌👌👌keep it like this. It's very useful. Understood protein synthesis.
@@RedMedBd 😇😊
kudos to the cameraman who captured these amazing videos just for us to pass our exams..😭😭
After watching this video..I am just speechless💓How beautiful explaination 😇😇
The process itself is too wonderful to understand .... that I & you are made of these things, that they are happening trillions of times per second ...
This video is so amazing and i finally found, how actual the mechanism of protein synthesis
Thankyou so much for this video 🙏🙏
My Brain is blown. I haven’t got a clue. All of this has been tested and proved correct. There are geniuses out there.
RNA Polymerase
Introns/Extrons
Spliceosomes
mRNA
Aminoacyl tRNA synthase
pyrophosphate
Amino Acid+tRNA+ATP
AUG Initiation
Methionine
Ribosome small and large Subunits
A site, P site, E site
Release Factor
Initiation, Elongation, Termination
Polypeptide
Endoplasmic Reticulum
Golgi apparatus
This is very easy to understand. In fact all i have to do when defining protein synthesis is to picture the video and i start to flow.
You really trust something you did not experience personally eh?
Thank you for such a video
I'm late on the scene, but this was really great. How far things have come since I was in college! Thank you!
Though this topic will be found in the higher class than mine ,but I'm still able to understand this very easily😊
Such videos are very much effective to increasing our Curiosity towards Biological knowledge. I convey my heartest thanks to you ❤❤❤
The best explanation in TH-cam
N:1 💕🇩🇿💯
The animation is superb i understand every process of it
Uhm, I would have liked this video yesterday. I had a exam about it yesterday...
@@RedMedBd I loved your videos ,,,,,and I subscribed too ,,,,keep it up ,great work ✌✌✌
Best experience with best visuals ever..❤️ lovet it
Good animation .....thanks for teaching me .....
Amazing ❤ one of the best animation I have seen 👀
2:50 Walnut
Amazing animation very very usefull In understanding thanku so much👍❤️
I understand nothing
so tru queen😍😍😍
𝐓𝐫𝐲 𝐭𝐨 𝐬𝐞𝐞 𝐢𝐭 𝐦𝐮𝐥𝐭𝐢𝐩𝐥𝐞 𝐭𝐢𝐦𝐞 𝐲𝐨𝐮 𝐰𝐢𝐥𝐥 𝐠𝐞𝐭 𝐚𝐥𝐥❤
Toh fir ja ke so ja
It will easy to understand if you first read from watson book then watch this video or vice versa then will be understood well
@@pranitadehingia4177 kaise ha Bhai
Bohut din bad tereko dheka
Very good explanation for understanding. Thanku very much.
Allah given the human everything wonderful🙂
MashaALLAH
Really,,,,very very good and full information with practical video...I m very appreciate to this
Had a fight with gf and watching this video to relax, what have i become...
🤣🤣
Haha lol🤣😂
'An intellectual'
nothing like calming down to proteins....
Very clear conceptual description. I love it
any ms ribkah students?😅
Me 😁
me too🙌
ME ME MEEE
☝️
mie ayam😅
So many similarities to how an oracle operates within computational theory. In fact, the entropy of the cell solves the halting problem