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- เผยแพร่เมื่อ 27 ต.ค. 2015
- Current medical treatment boils down to six words: Have disease, take pill, kill something. But physician Siddhartha Mukherjee points to a future of medicine that will transform the way we heal.
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This gentleman is going to win the Noble Prize for medicine in the near future. All the very best
Or will be dead, cuause he close the door for business to get money lol
Yup
Absolutely. He will , all the very best,the whole world is looking at him now he's definitely gonna reach a revolutionary conclusion 'bout cancer.
As a young biomedical engineer, this is really exciting!!
+alberto meza How do we get cells in? If we can't get them in position, there's no point in growing them.
+rawstarmusic we actually can, with nanotechnology, just give 4 years
alberto meza Well I hope that's true. It would have to be very advanced to build and program this vehicle. If cells could find their own way it would be so good.
+alberto meza as a medicine student, m2! ^^
+Jack L.Chen Medical students unite!!!
This Ted Talk came at a moment when I was deeply doubting the current approach that medicine takes towards healing people by assaulting their diseases with pills and scalpels. The human body is capable of wonders when put in the right environment. I could not have agreed more.
Love the concept. Let's move away from a sick care system and move to a well care system.
SCP-500: Am I a joke to you?
Agree 100%. However, the profit is in treating disease therefore a well care system is highly unlikely to be provided, we'll have to do it ourselves.
we need more TED talks like this!
This was a wonderful talk. Interesting, encouraging, and logical.
TED still does science talks?
+vadagh Barely..
+vadagh I know, the shock!
Yeah the feminists must be on holiday LOL
Still are, even 4 years after this comment
Such a brilliant guy. He currently teaches at Columbia. true gem
Does he have a single first author publication? Even one?
@@dato007who cares
@@dato007 Yes
I love watching Ted talks about medicine. For the sake of the future.
Like, the other day I saw a guy talking neurosurgery with photocuring(Can't quite remember the name), it was about planting a seed into a brain, which would then target specific areas, affected by disease, and would essentially allow us to turn them "off" just by exposing that part to light.
And every time I hear something like this, it makes me so happy that our children and grandchildren may never witness horrors of slowly losing their beloved ones to brain infection or, in case of this video, to cancer. All because some man thought outside of the box, and invented new ways of curing something.
Medics are demigods, I swear on me mum.
Very brilliant and confident speaker. Well done Siddhartha Mukherjee! I will definitely be looking you up more often now.
interesting talk and it changes your perception of solving problems
This is one of the most important talk on medical science on TED.
We still know very little about our own bodies. There is a whole world to be discovered within.
***** You are a very ignorant person.
The blind leading the lame... LOL this is so funny!
The Truthful Channel our bodies have been studied for centuries. Lmaoo you’re very stupid
@@Elmamaguebo16 then why are we not immortal yet , you are moron
never have i been so captivated by a ted talk!! my true inspiration is him , the man who thinks outside pills.
Cell-based therapy is really something. I culture dendritic cells for cancer therapy, which is a pretty mild adjuvant treatment, but there are some really crazy cells being developed out there. Read about CAR T-cells used at Memorial Sloan Kettering, Upenn, and Baylor.
This guy is so impressive
His books are fabulous.
man this is completely underappreciated
amazing....I'm 14 years old and would like to become a neuro surgeon
Please keep watching ted talks and read as much as possible
I would suggest you to study as a doctor, but specialise in stem cells therapies, as they're going to replace all the current medical science. Current medical specialities are going to shift dramatically in the next 20 years and there is not going to be doctors like in our days.
@loyal4 the way 500-1000 K a year, fulfillment found in serving and leading your community, a crap ton of prestige. It's not for everyone, but society would suck for anyone with a glioma if nobody wanted to be a neurosurgeon
A good read for you: Why Isn’t my Brain Working, from Dr Datis K
You are now 19
Inspiring talk for this girl(me) who wants to make a new world with research
Amazing talk about amazing progress.
Yes, work with the body & or improve it's ability to self-heal.
If he is bengali, he has such a crisp accent.
Anyway, back to the video.
This was an amazing presentation. The delivery and approach were outstanding.
Great work!!
Absolutely breathtaking speech..
I am reading his book -The Gene, fantastic.
My undergraduate studies were focused on biological systems and treatments using novel drugs. I worked with many different types of novel drugs. There were many drugs that were previously tested by other facilities but did not produce the theorized results. We noticed that there was a possibility they interacted with what we were working with and thought to use them in our studies. Sometimes they worked but often we published papers demonstrating there was no relation. This taught me exactly what Mr. Mukherjee is explaining. We need to open our minds up to other ideas of treating disease.
Since starting my post graduate work, I’ve been excited to learn about the development of treating some cancers with your own immune system. It’s so cool to see how well this Ted talk has aged when it comes to the question of “Could your medicine be a cell, not a pill?” To quickly summarize this idea, your bodies immune system is “taught” what each other cell “looks like.” It’s true that cancer cells are your own cells but they can have many different mutations that alter their outer proteins. They’ll look similar to your own cells but different enough that it’s possible the train your immune system to target and destroy those cells.
From my understanding, modern day medicine is coming the ideas of “Could your medicine be a cell, not a pill?” and “Could your medicine be an environment?” It would be easy to just say “ramp up the immune system to full capacity” if it meant getting rid of all cancers but that can cause equally dangerous problems. There are internal environmental conditions that cause an up-regulation of your immune system and others that cause a down-regulation. Your body is always balancing the two. Too high and you may end up with an auto-immune disorder while if it’s too low you are vulnerable to opportunistic diseases that can kill you.
It’s really exciting to be a part of the generation that may have the ability to fully understand the body and create health for everyone.
If you’re interested in the above ideas you can search for “CAR T-cell therapy” for a more fulfilling understanding.
Is the end of cancer in sight?
this man is one of the reasons why i want to become an oncologist
Now this is what you call a TED Talk!
Author of 'Cancer: The Emperor of All Maladies' Awesome book. Do read it people! :))
Rahell Omer I certainly will.
Haha, got it right in front of me :)
I read it before I come here
It's on my reading list!
Wonderful!!!
Yes. In the next few years, medical innovations will be all about utilizing the best of healthcare technologies.
One Word Asilomar. Crossing the pivotal lines. If you don't know look it up...
amazing....
Today marks the beginning of a scientific motivational journey I'm taking and this video (Siddhartha Mukherjee) has taught me that comabting disease is more of a matter of thought than tech -Dw, The Grooveman (July.31.2018)
Thanks
It’s March 2020...
Let’s see in this next year what happens. I’m hearing things about a new world. New health.
Proud from India sir
I also agree that "This gentleman is going to win the Nobel Prize of Medicine".
He deserve nobel Prize
Read his book "The Gene", is the most important book on gene.
I lost him mid-way through the talk. He obviously is saying something interesting, but I couldn't link it with any of the stuff I now know. I am currently reading his book, Gene. Hopefully things will fall into place soon.
wow.. hopefully my internship next year will be easy..
Muito bom.
MASSP 2019!
yes yes yes
Superb
very inspiring talk
Over 3 years since this talk. Science is slow and innovations are slowed by big government and big insurance companies.
Science is fast..........Implementation is not........for the reasons above and beyond
Wow
Thinking outside the box, people.
10out 4people suffering from backpain , disc problem
10years from hearing stemcell treatment future promise , where?
Principle of medicine i'm reading it
His hair is the Cure.
+Synerrox เ In the future, all shoes will be made of cloned strands of his hair.
If this talk had been given years ago it would have been very impressive. As it is, it's just saying, 'what if we could do these things we've already started doing?' There are already people walking around whose knees have been repaired with stem cells, Joe Rogan makes one well known example. There are researchers already working on making 3d printed organs that can be implanted; Anthony Atala's work has been featured on TED 3 times over the last 5 years. Aubrey de Grey's organisation, SENS, has been researching modifying the body's function to prevent degeneration and restore degenerated function for some time now. These ideas aren't actually all that new. I suppose they might be inspiring to a young med student if they haven't heard of them but I'm really not impressed with the way these ideas are presented if that's the goal.
You'd be surprised to know how little people on average know about cutting edge biomedicine
Most people are not aware of this stuff, partly because most of these therapies, despite it being obvious that they are leading to amazing things, have not been approved by the FDA. If you want to get a lot of this stuff you have to have a lot of money and go abroad.
Dominance?
I am looking a utilizing adenosine triphosphate to modulate cell function through purinergic signaling. My article is The Therapeutic Potential of Adenosine Triphosphate as an Immune Modulator in the Treatment of HIV/AIDS: A Combination Approach with HAART.
No mention of diet?
It’s coming this year.
Indians are indeed the sharpest.
T-cell transformational therapy is indeed, medically speaking, revolutionary and truly innovative. However, personalized medical treatment could become invasive technology, which could need conducive environment for sustainabilty and power of healing in a global manner
Soon means how long? Did someone watch the video and could give me a summary?
Each "natural" human death is a step forward in evolution. If our perception of death wasn't as final as it is now, perhaps we would shift our focus from trying to save lives to letting people die in order to evolve as a specie.
But, the reality is that we know nothing about mortality, and most people held tight to the last drop of life they got, of course very understandable.
+Silver Mirai
You die, you're dead, mortality is quite simple and the epitome of "final". Dying doesn't influence evolution directly but indirectly, it simply increases the possibility that someone that is more "fit in the environment", or resistant in the case of infections, will replicate with his kind. But this only works for anything that kills you before you replicated, not for cancer, not for Alzheimers. You'd have to start eugenics right now to get proper results in the important time frame (that is the next 50-100 years), but eugenics are way to toxic to society to think about it.
By your own logic, please die.
TheAnnoyingGunner I should mention that death is not important in evolution, but reproduction, for myself I have decided not to reproduce for philosophical reasons, so either if I die or not it doesn't matter, my genes will not be perpetuated, unless some unplanned thing happens.E.g. while having sexual intercourse with your mother, the condom breaks.
In any case, you don't fully understand mortality if you think about it as final, biologically speaking the atoms that composes what we call our body is always changing, after we die those atoms remain in the universe, quantitative nothing changes. Only arrangement, bounds breaks, new atomic bounds form.
As for our consciousness, no one knows and we can't deduce any theory as higher likely or not, there is no empirical evidence to work with outside statements from people which is not scientific.
A good theory could be very well be, if we started existing once, we could exist again, there is no restraints for that, a chance is a chance, if something happens once, there's no reason for it to be prevented to happen again just because it happened once, and vice-versa.
People like you who give final verdicts to things that are unscientifically proven are basically why our planet is fucked up, just like your mother. Are these mom insults working on you ? I hope you feel bad.
Silver Mirai
I see things from a wide perspective, but that doesn't impair my ability to smell bullshit. Antibiotics wear out, because we eat them as they were vitamins. They get prescribed as precautions, in cases they don't even work or they are not needed as the infection is not serious and could be treated differently. Not even touching the problem of patience compliance. This is the reason why we burnt through most of the available antibiotics.
But it is startling that you don't understand why pathogens had the upper hand until we discovered antibiotics. They had the upper hand for thousands of years, hundeds of thousands. For a genetic improvement, you need to reproduce, this happens every 25 years or about 16 in the past with the positive outcomes being marginal. Microorganisms replicate a few hundred thousand times in days, you can't outrun them in terms of genetic evolution. Also, if we beat them we don't beat them due to systemic changes, we beat them due to our antibodies and those we don't inherit. The offspring can absorb antibodies until a few days after it's birth, but after that it is on it's own, the cycle starts anew, the absorbed antibodies decay and don't leave the newborn with ongoing immunity.
You know, there was a guy that held similar beliefs to you, he started the second world war. Just mentioning so you recognize on which level you are arguing.
TheAnnoyingGunner You're raising a good point on the first glance, but then again, you didn't take in account that our bodies are complex, while micro-organisms are simple, we can evolve complex biological general self defense systems to fight infection, we already have one, it fights many things, not perfectly, but with time it can become perfect, no matter how micro-organisms would evolve, if we had a perfect immune system, we wouldn't need antibiotics, even chemotherapy, the immune system has a way to deal with cancer cells right now, it's not perfect, this is why we develop cancer. Micro-organisms have a limit to their evolution, complex macro-organisms do not. This is the one advantage we have over them, the most major one. In the long run, we win. And yes, I agree with the fact that people misuse antibiotics. and yes, we can develop new ways to fight infections, conditions and diseases, but in the long run, we're slowing down our evolution.
I'm not saying we should force this on people, just a thought, it's never wrong to want to know the truth, to speculate. I never said I wanna force people to do this. And again, we're talking about not reproducing, not necessarily death. The last part was really uncool of you to say.
Silver Mirai - There is no such thing as “a perfect immune system”, at least not a naturally created one, and we don’t have thousands or millions of years to wait for evolution to fix things. For one, the infectious diseases that affect us are capable of evolving many orders of magnitude faster than our immune systems. Evolution is a constant back and forth battle for survival of all organisms, not a linear path that looks out solely for the best interest of humans. Ultimately technology will unlock the physical and mental potential of humans.
Hi. How can i get in touch with Siddhartha Mukherjee...?
50-100 years away unfortunately. For me I wish they could repair and heal nerves better. I have had 3 surgeries to try and fix a nerve in my ankles and it didn’t work. Now I take daily medication at the age of 25. I wonder how my daily living will be effected unless medical advances happen sooner than later.
They have made great advances in spinal cord stimulators though.
Hi sir! actually there is now a live cell therapy that may help your problem sir. send me a message if you're interested. remoquillojeremy@gmail.com
THE PRANAMBEST
Can you treat rp eye disease by this concept nowadays?
He reminds me of that one guy in that one jurassic park movie
+Aggressive Videos mr masrani...
Yeahh..Jeff Goldblum..
yah, like life soon will be back where it begin too, a single cell.....
my body is ready
Why can this man teach me mri physics....why? I could fall in love with it or at least pretend to like it
For 90% of the diseased people worldwide breathing normalization and the correction/reduction of risk lifestyle factors must be a central part of their treatment for them to be able to heal.
TEST THIS OUT FOR YOURSELF
Breathe very deeply for 5-10 minutes and you may experience an asthma attack, blocked nose, dizziness, chest pains, palpitations, coughing and many other symptoms. Reducing the depth of your breathing by breathing shallowly can reverse these symptoms often within a few minutes.
Cultivated organs would be great and also removing defective cells and replacing corrected version this would be infinitely better than our current strategy.
+nickjoeb How do we get cells in? If we can't get them in there's no point in growing them. We just have fabulous cells on a plate.
+rawstarmusic probably shots or surgery.
Am I really just seeing a guy from India without a funny accent??? My world is shattered.
+YouHolli He has a funny accent.
As an Indian person born and raised in America, his accent is still funny to me :P
+YouHolli He has a good indian accent. Most are nearly impossible to follow. There is something special about mixing indian and english, they don't mix well and the speakers can't hear it or change it.
+YouHolli
You'd be lucky to find any English-speaking individual, or any other language for that matter, who *doesn't* have an accent of some sort. Of course, it's human nature to find funny anything that's different from oneself: that's one of the bases of humour.
Strangely, even though I could hear and understand perfectly well everything that SM was saying, it was difficult to avoid reading the subtitles - my eyes were too easily distracted by their presence: just as others might be distracted by a variance in auditory stimuli.
+YouHolli i find your accent funny, i havent even heard you talk but i find it funny already.
i will be very disappointed if i am not a cyborg in 50 years.
genetically enhanced cyborg
Senk Yoghurt well, your cyborg must have the function to dab on them haters
I don't get the feeling about becoming cyborgs... rather I feel that medicine is going to progress in such manner that we can extract the stem cells and prepare them to heal our bodies. We're going to be a population of perpetual healthy people.
Wholly agree
How much would the inovation cost?
Has anyone Watched HEAL Documentary on Netflix? (Bruce Lipton, Dr Joe Dispenza, David Hamilton etc.)
Just "Heal"?
Is it still possible to watch there?
Be nice to see in depth Food as Medicine Research. "Science of Medicine is the noblest science that human beings have ever been able to develop." ~ Some Aspects of Health and Healing, Baha'i Faith
My wife passed stem cell treatment in Belgrade , now she can breathe normally again. She's suffering from COPD
Michael Chen sorry to hear that! Hope she’s doing well. Just curious, was she a smoker ?
Could the regenerative cell supplant and heal the killing pill for sick and dying patients all over the world?
Loved your concept but at the same time its very disappointing that we will loose millions of our dear ones till we reach to that eutopian state.
Please come up with some thing done we are in urgent need of help as victims of cancer family.
Hi! Actually there is, there is now a live cell therapy that is convenient, effective, and affordable to get the benefits of stem cells, and it helped a lot of people with diseases here Asia. If you're interested we can talk about it. here's my email: remoquillojeremy@gmail.com
4 years. How far have we come? I’ve heard nothing.
we have developed a tech-CRISPR-CAS9 which will help in gene editing, even Chinese are successful in editing genome, we are progressing very fast
Rahul Kumar yes I have invested in the company CRSP. Studies are moving extremely slow.
@@killap3nguin but I think because it's too dangerous and involve many moral, ethical questions which can divide people on ideological lines, like stupid no-vax movement in USA
Exactly, rightfully the standards for the biotech are extremely high to get into. We have tons of animals studies and in-concept have highly effective therapies. The main problems are first, as said before, the ethics of carrying out these things on humans and second the cost. Europe is slightly less strict about stem cell research compared to FDA so you can see more companies or institutes applying it over there. For the question of immunotherapies for cancer let's say, it's mainly the cost (almost $500k per patient). But I can assure you that the development is really exponential. The bow is getting stretched by the research of over 30-40 years.
Rahul Kumar what does that exactly do ?
You're talking about external creation of organs. Would you actually consider repairing the existing organs in their own environment without any transplant surgery?
Anything could be possible, but practically speaking, once the cells have degenerated and the tissues are no longer functioning it is easier to have a new one than try to salvage the damaged organ.
HMM
It's cold in there!
+Sym Eof Use blankets. Eventually your built-in heat maker will switch on to hot.
_This talk is great in a way, not because he is telling something new ('coz they've already been done), but more of how he had drawn a _*_level of abstraction_*_ that could be generally applied in the field of medicine._
But I have my *second thoughts* on the _controlled environment_ aspect; not much as to its _causal effect_ on our health but as to how you could _effectively enforce_ a *_desirable state_* on a *large scale* so much so that today's individuals are criss-crossing not just State borders, but also from one sovereign country to another. Our laws could only stretch so much as to territories which we have jurisdiction, in general.
Nonetheless, *The Cell-to-Organismal Approach* is one disruptive principle in Medicine; beyond that would be a socio-political intervention already.
Good. He is in. RPA. Emperor of Maladies was true.❤
But how do you get in vitro cells in??? He doesn't even mention it. When cells malfunction or is missing, you need lots of cells in very specific areas and that seems to hard to achieve. Can it be done?
+rawstarmusic
It all comes down to stem cells, but research on them has practically been banned in the western society except Switzerland. A few years ago, a bunch of scientists developed a method to reprogram adult cells into "induced pluripotent stem cells", but while they behave like stem cells they are no actual stem cells. We don't know how they will behave inside the organism on the long term.
You can apply stem cells directly to the disrupted tissue, the cells sense the environment they are in and differentiate accordingly. They grow to replace the missing tissue, but of course this only works locally.
TheAnnoyingGunner The banning of stem cell research should be abandoned if your info is correct. I read that stem cells can be taken from the individual himself. Cells from aborted fetus should be allowed again because the parents have decided to kill it. It doesn't matter if it gets buried with all cells in place. So at least with the parents permission it should be allowed. That is more ethical than just throw everything away.
The growing of cells seems to be very successful and nature is so kind to let cells take on the right function once in place. To get the bad cells out and the fresh cells take their place is the discovery of the century in medicine. It seems impossible right now. Bacteria know how to do it and to some extent some drugs that reaches everywhere but has no effect in the wrong places but this is living cells so they can't go by the digestive system where they would break down into pieces.
I read about successful bone marrow replacement. It's local, closed up in a bone capsule. But cells that should produce body essentials can be spread anywhere. It's a triple Noble Price waiting for that solution but I don't see it. I didn't see the theory of relativity either so it needs a special bright mind because if ever successful it would be a revolution for human medicine.
*****
Well, if course no one is hurt if you use the embryonic stem cells of an abortion that is taking place anyways. But then, do you pay the parents a little share for their contribution to medicine and science, practically oiling the palm? This way, you would commercialize the trade with aborted embryons and people would start to abort for money. Which is hugely controversial at the moment.
Not that I'd care, we have enough people on the planet already and in my opinion they can sell whatever part of their body they want, including the embryo. I don't attribute legal rights to insentient organisms.
TheAnnoyingGunner For me personally I wouldn't pay a nickel or a dime. They get their abortion done which is what they want. It's bad enough to kill an individual to avoid an unwanted pregnancy. I am for abortion but that is as far as it goes. I would be against an organ industry whereas a donation is good.
An aborted is a person doomed by its parents which do not want to give life so that's the edge for me. When it comes to number of people in the world, I never had this "we" opinion myself. Every human life is a whole world to me, basically the opposite of cells where no cell has an individual value. I see so many people here on youtube and everyone is valuable even if "we" could do with much less so I understand it from the inside out.
This is because I regard humans as a higher life-form than say a fish or mosquitos. So I'm not a utilitarian where killing of a billion people with a famine or epidemic would free up resources for the others. For utilitarians killing the young would be most efficient and easy since they can't defend themselves. Somehow this thought gets rejected by my emotions.
TheAnnoyingGunner Btw, how are Switzerland who allows research doing?
Year 2035: "WE FINALLY CURED CANCER!"
Drug resistant bacteria: "Hello there!"
We hve cured it but treatment is quite expensive.
What happens to stem cells after Radiation & chemotherapy?
Environment/Lifestyle is #1 trigger of dis-ease - well established.
What % of global population suffer from iatrogenic illness?
Sooo..is medicine worth pursuing 40 years from now?
Amazingly 5 year old vidoe and 2.4 lacks views only ... 🤗
Like sooooo soooooon
Cells ?? Yes.... The DNA in cells...Via CRISPR CAS 9.Genetic engineering.
👌👌👍👍👏👏
A new frontier to be conquered, personalized genome is the logical direction, medicine as I know has become obsolete.
Awesome! Fix aging please.
+Yijuwarp Thats not how it works. Thats not how any of this work..
Ali B
Since the body is a complex system and aging is simply systemic failure of the system due to buildup of small failures which cannot be remedied internally it seems to me like learning to rebuild our bodies using stem cells would be a key element to fixing aging.
Yijuwarp I understand but aging is not one element, there are many aspects to " aging ", as it happens all over the body, just one stem cell modification or application is not going to do much. I understand your point, but we are no where near stopping or reducing aging..
Ali B
maan, i was joking, I also understand the problems. Obviously even if we can rebuild every part (not saying ability to use bone stem cells = all stem cells) we will still be dying for various other reasons (calcification of arteries, various cancers, etc).
Just saying its a very important first step, if you have ever injured your hip you will also know there is almost nothing worse than being disabled like that, completely unable to move and in pain all the time.
+Yijuwarp A very small first step, but a step is the start of anything...
When we'll cure disease with cell? It's being 5 years but no results?
I am indonesia
Well, let's phrase it this way:
The approach isn't that far off. We shouldn't try to "engineer nature" in labs within a few years when nature itself has formed the best possible methods for 3 BILLION years already.
A good example for a cell as a medicine is a feces-transplant. The bacteria in the feces actually re-cultivate the natural gut flora, eventually becoming part of the body. This procedure has helped a lot of people with certain forms of colitis. The reason for that is that nature itself has the best solutions for us, we just have to figure out how to use those solutions, bionics isn't it's own science-field for no reason.
Maybe cultivating certain cells to treat diabetes or cancer is the way we have to think about the future of medicine, combine that with the current medication to make sure we suppress negative effects of that and poom, we have a medical revolution.
Most medicine is only suppressing negative effects anyway for a reason, our immune system is the single best weapon against invaders. In 150 years of actual science we haven't found a way to get rid of a virus, other than alcohol and other disinfectants while our body handles viral infections on a daily basis without any problem.
+Finkel - Funk
We have quite vicious means to kill an active virus, they are called virostatics. Not useful against the dormant virus though, but you can't specifically target a dormant virus with drugs and a temperate "sleeper"-cell at all, by principle. My personal favorites: DNA-/RNA-Polymerase inhibitors, as soon as the virus starts to replicate it's genome it ends up with a disrupted genome.
TheAnnoyingGunner - Ironically viruses can also be programmed to heal, so they are a double edged sword ⚔️
Finkel - Funk f