How to recognize Left-Handed and Right-Handed DNA?

The only purpose of this video to teach you how to recognize - right and left-handedness of DNA. (DNA shown in the video is not perfect representation of A, B, and Z conformation of DNA) but clearly shows conceptual idea of right and left-handedness of DNA.
When you see DNA depicted as a double helix, you can clearly see that its structure is twisted. That twist makes DNA a "chiral" molecule, meaning it is asymmetric in such a way that a DNA molecule and its mirror image are not superimposable. Examples of chirality are everywhere. Take your hands, for example. For all intents and purposes, your left hand and right hand are mirror images of one another, but no matter how you twist or position either hand, you'll find that it is impossible to orient the two of them in exactly the same way. Chirality is the reason you can't shake a person's right hand with your left, or wear your left shoe on your right foot.
Chiral molecules are said to possess "handedness," and in DNA, that handedness is characterized by the direction of its twisting strands. DNA's right-handedness can be identified by a simple trick involving your hands. Take your right hand and, with your thumb pointing upward, imagine grasping the spiral pictured here (in this diagram there is only one helix... in DNA there are two, but this rule still applies). Now imagine your hand twisting around the outside of the spiral, tracing its grooves in the direction that your fingertips are pointing. Your hand should rotate upward along the helix. If you try this trick with your left hand, again grasping the helix with your thumb pointing up, you'll notice that following the rotation of the helix in the direction your fingertips are pointing will cause your hand to move downward.
That means that if you're reading an article online or in a magazine and it features a picture of a left-handed double helix, that picture is wrong, wrong, wrong.

[@himul9526]

Another method :
Imagine a ds DNA helix with more than 1 turn (say 2). Now imagine untwisting the helix from the bottom such that u get a straight ladder. Now notice which way u had to unwind the DNA helix to obtain the ladder?
If it's counter clockwise, then it's a LEFT HANDED DNA
And
If in a clockwise direction, the DNA is RIGHT HANDED.

[@Stevez221]

nice one

[@showkathussain2552]

Brilliant

[@dariov99]

I love u for this

[@muskandeepkaur7145]

Thankyou so much ,helped a lot

[@shafiurrahaman3396]

Wonderful methods in the video and comments! One I haven’t seen yet, though might have been mentioned, is to consider the DNA strand and then look at or draw imaginary straight lines following the border but only as it rises at the front facing us and you will see it points up to the same direction as the handedness
(Not as it wraps behind because then it points the other way)
So for the right chain the blue border lines of the dna in the video go up to the right
Sure enough the lines point up to the left with the left handed strand
If my explanation isn’t quite clear, pull up a picture of those red and white barber twisting tubes and look at the border lines made between the red and white, it rises up to the side that is it’s handedness

[@RavenCammenga]

Very nice explanation with the use of the stairs, I finally understand, thank you Nikolay! (greetings from the Netherlands

[@GeneticsLessons]

You are welcome! Thanks for watching.

[@OdiaSongLyrics]

Thank you from me as well

[@gammondog]

A method I use for screw threads to stand it up vertically and look at the threads from the center. If the thread rises to the right it’s a right handed thread. And vice a versa. Most are right handed. The ones that rise to the left are left handed and are often called “reverse threaded screws”.

[@afterfestival8155]

Thanks William your way really helped me relate with it

[@GollakotaPrithvinath]

I just went through your uploads and the content is overwhelmingly huge! I am a Genetics major undergrad and all your content seems so interesting and informative for me. Subscribed! You deserve a much larger viewer base mate. Keep up the good work!
Love ~ Prithvi ☺️

[@Viridian88]

The staircases analogy works really well, thanks!

[@GeneticsLessons]

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[@swagatmallick209]

You really explained it well with the stairs. Totally clear...thank you 😃

[@GeneticsLessons]

Glad it was helpful!

[@bigfootpegrande]

Thanks for clarifying in such didactic way...

[@GeneticsLessons]

You're welcome! Thanks for watching.

[@antonyshigin4977]

Thanks a lot sir...Finally I got this idea through your lecture....🙏🏻

[@GeneticsLessons]

Great 👍

[@latimd6287]

Thanks Nikolay, I understood both analogies ( the staircase and the screw).

[@sharikak4743]

Thank You Sir, Helped me a lot

[@GeneticsLessons]

Most welcome!

[@Lovely-bh3ln]

Staircase helped me a lot omg thank you

[@GeneticsLessons]

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[@GollakotaPrithvinath]

Very nice explanation. Intuitive approach. Thank you! Keep up the good work!

[@Michael-zd2le]

Easy to follow and understand. Thank you so much!

[@GeneticsLessons]

Glad it was helpful!

[@niks8924]

Finally I got the concept behind left and right handed DNA...

[@moonchaser5431]

amazing explanation, could finally visualize this concept, u made it so simple, thank u!

[@furdosalhamdani2847]

شكرا على الشرح البسيط❤

[@simplysweetjn]

perfect analogy thank you so much for your expertise!

[@GeneticsLessons]

Glad it was helpful!

[@brianb6096]

Thank you, now I cant unsee it.

[@MedicalwallahAyushpandey]

Thank you sir lots of love from india

[@younesabuelayyan4520]

that was helpful thank you

[@GeneticsLessons]

Glad it helped

[@mayaviasur2354]

Thanks human for this : )

[@user-zh4mu7ki4t]

You are toooo good... Cant thankyou Enough for this..

[@MehwishKhan-hd5bw]

Excellent example 2:37 .., thank you

[@GeneticsLessons]

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[@thatgenius8631]

Thank you for this ...so we have to hold our hand in reference to going up not down ...right,?
pls if anyone can answer it will be really helpful

[@GeneticsLessons]

Yes.

[@thatgenius8631]

@@GeneticsLessons thank you ..btw this video really cleared my confusions

[@vomulavaishnavi2672]

Thank u sir love from india🥰🥰

[@박계현-f3u]

Very nice explanations! 😆

[@GeneticsLessons]

Glad it was helpful!

[@benoitmichel9258]

Nice job, thanks a lot for your help

[@GeneticsLessons]

You're welcome! Thanks for watching.

[@kohshyangjen2097]

Wondered how was the both handed.

[@GeneticsLessons]

It is also happens when same chromosome's some fragments could be right handed and some left handed.

[@born2killjayanth984]

Thanks

[@KhunJuju-B]

Well explained.. Thanks👍🏼

[@GeneticsLessons]

Glad it was helpful!

[@DeermanDr]

Thank you I finally understood it.

[@belajarsnowboarding]

Check the 5-3 position, pls

[@GeneticsLessons]

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[@shifalijangra9570]

Nice explain 🙂

[@GeneticsLessons]

Glad you liked it

[@salihabenkhaled1026]

thank you

[@GeneticsLessons]

You're welcome! Thanks for watching.

[@dryleaf9681]

Thanks mate

[@Apoptotickitler]

thank you so much ^^

[@GeneticsLessons]

Ok, so you got it, at last? :-)

[@Apoptotickitler]

+Nikolay's Genetics Lessons
Yes i got it after trying to determine the forms of some dna illustrations by myself with your method & it really works . thank you sooooo much :3

[@GeneticsLessons]

You are welcome! Thanks for watching.

[@Apoptotickitler]

+Nikolay's Genetics Lessons
^__^

[@husseinmahdi9510]

you are welcome ;)

[@Shellshellzee]

So is it correct that a person who is right handed, has right handed dna, and a person who is left handed, has Z dna? 🤔

[@GeneticsLessons]

No.

[@Shellshellzee]

@@GeneticsLessons How can we know which type of dna we have?

[@GeneticsLessons]

The form common to all living organisms is a right-handed double helix, known as B-DNA.

[@GeneticsLessons]

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[@kyelangrehr183]

But what reference frame for up is their for DNA? what happens to its handedness if you rotate any of these images 180 degrees. which is what was actually done for the first two images just imagine the number aren't there and what are you left with.

[@GeneticsLessons]

What going to happen to your right hand if you rotate it 180 or 274 or 90 degrees - will it became left hand? :-)

[@kyelangrehr183]

@@GeneticsLessons the whole point of handedness is that you can't just rotate it or get a different perspective of it now mater how you look at a right hand it won't become a left hand. In the stair example is some what trivial to I identify what way is up but that's what makes it a bad analogy. Unless you can point to anything in or on the DNA to identify what up is.

[@kyelangrehr183]

No sorry think I see it now.

[@Apoptotickitler]

still can't get it ;-;

[@executiveengineercd-i8275]

same

[@makulmahato8663]

Watch d screw part. Ull get it.

[@GeneticsLessons]

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[@Crunketh]

Opochtli DNA is left handed

[@GeneticsLessons]

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[@MoukhlesDerbal]

Thanks