DNA replication - 3D
ฝัง
- เผยแพร่เมื่อ 25 มิ.ย. 2015
- This 3D animation shows you how DNA is copied in a cell. It shows how both strands of the DNA helix are unzipped and copied to produce two identical DNA molecules.
To download the subtitles (.srt) for this video, please use the following link:
drive.google.com/file/d/0B1Cb...
For more information, download the video, and explore related resources on our site: www.yourgenome.org/video/dna-r...
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Animated by Polymime Animation Company Ltd.
www.polymime.com
/ polymimestudio - วิทยาศาสตร์และเทคโนโลยี
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Learning about replication without actually seeing it makes actually no sense. A must watch for anyone studying biology-related sciences.
Yess! I really needed to see the process, because I was getting confused while I was reading about it in my textbook.
This is just an animation 😂
Yea bro
Same. I'm having a bit of trouble actually understanding this process and remembering it.
*Boomer af comment incoming* Imagine not being fortunate enough to see it like this?
The original G's must have done a whole lot of figuring out to get here.
Here is a basic & simplified version of the video:
BASICS:
Adenine --> Thymine
Cytosine --> Guanine
PREPARING TO REPLICATE:
-Helicase splits the DNA for replication
-Primase adds RNA bases (primer) to the leading strand.
-Why does DNA polymerase require a primer before it adds DNA nucleotides? It is because the RNA primer will have a free -OH group at the end that it can nucleotides to!
-DNA Polymerase binds to the primer to start replication!
REPLICATION:
-The leading strand TEMPLATE will have a daughter strand that is created 5' to 3', in the direction of the REPLICATION FORK (where DNA becomes uncoiled).
-The lagging strand TEMPLATE will have a daughter strand that is ALSO created in the 5' to 3' direction, but it will replicate in the OPPOSITE direction of the REPLICATION FORK.
-That's not okay! Because it is in the opposite direction of the replication fork, it needs to be made in fragments (Okazaki Fragments).
FINISHING TOUCHES:
-Exonuclease removes the RNA primers that were added to the start. We don't want RNA in our DNA!
-DNA polymerase then adds DNA bases to the missing spots where the RNA primers were.
-Ligase makes sure all the fragments are sealed
CLOSING:
-DNA is described as semi-conservative because there is one old and one new strand of DNA in each DNA.
Thanks and hopefully this will help you for your bio test
I know it did for me :)
thx
Thank you so much! This helped a lot!! Really appreciate you putting the transcript out here :))
@@velvetbar9388 You're welcome!
Sukriya mere Bhai
The video was the simplified version.
My biology teacher explained really good and now seeing this video makes dna replication totally clear to me. Thank you!
let's switch brains please I'm dying we have exams tomorrow, my teacher explained it too fast for my brain to process it all TvT
@@Fifi93321 ikr this topic is really hard if we just try to read it-
It requires high imagination power to actually visualise the whole process. Anyways don't worry too much and just think how beautiful the whole mechanism is. And all the best
@@kaushikpradhan25 our exams are finally done! I'm free!!😭😭😭 there are a few questions where our teacher didn't explained it 😭
My biology teacher explained this poorly and this video helped a lot
@@Fifi93321 i get questions like that too, but i think it’s just to test your critical thinking of the particular subject. the questions contain info that i’ve studied, but it is worded in such a way that makes me confused af lol.
Almost 8 years ago and this is one of the best DNA replication videos I've ever seen so far! Great visualization!
As a senior bio major I shed a tear watching this... so beautiful
why the dramatics
love that energy loll
lol
I understand why . It sounded so messy in our classes , this is fantastic explanation and visualisation
Bit dramatic but okay! 👍
Anyone else here because their professor cannot explain things simply?
Yasmine Vella i am here because of this
I am. Seeing it in action is a much easier way to visualize it in the test.
Actually...
You discovered me ._.
ya
here cause I did not pay attention in class
حيا الله طلاب السادس العلمي بويه
Final year high school students in Iraq welcome you 🥲🇮🇶
2024 attendence here ❤
First 🎉❤
Here!
How long ago was this uploaded ???!!!
Take notes, biology teachers. This is how you teach this.
👍🏻👍🏻
biology teachers are not graphic designers
@@beatrizzzzalves they probably mean pulling up videos and lots of imagery so there's a visual element making it easier to understand
There's another amazing video regarding steps of DNA replication. You must check it once. I hope this might clear all your doubts.
Links here.
th-cam.com/video/oa6gjPZS2kk/w-d-xo.html
In this video , idk if i didn't understand replication or not , but the enzyme at 2:41 is not supposed to be able to move that way( to take that direction), it is supposed to be linked with the second DNA polymerase and take same direction.
Sry for my english hard for me to explain hard lessons with a language i don't master.
Τhis was actually the only video that made me finally understand it..good job :)
Lena D. plz watch replication on my channel I can bet its the best on youtube
Erm, "Mr Biology" we'll take that bet. I think you'll find that THIS video is the best on youtube 😉
awsome and help ful
I understood replication process in real sense by this video.
Keep on.
I understood...But how to write it for exam...
Any neet student here😅
Me😂
Yehh 😂
😂me
Me 😂
Me😂
im literally crying because this is so good. merely reading the process just screwed me. thank you so much for the efforts.
Absolutely!
Very well explained 👏
This video is amazingly incredible. It is precise, up to the point and explains everything in 3:28 min with clear voice with synchronized animation. This video is the best that explains Dna replication on TH-cam. It probably deserves a million likes
fam youtube is not a learning app, this does not deserve 1mil
@@scraw428 roughly 50% of people on youtube use it to learn new things though
🙌
@@scraw428 I use TH-cam for entertainment and education
@@scraw428 A stupid comment.
A 3.30 min video made me understand what 3 lectures of 2 hrs each couldn't !
I'd lost all the hope that I'd ever understand replication, after watching this precise , short and easy-understanding video , I'm feeling refreshing now. Hats off to that person who made this...
That's a gem.
Three & half a minute is more precious than three & half an hour without seeing the animation.
I’m French and I’ve understood it better in English because professors or unable to EXPLAIN IT CLEARLY IN A SIMPLE WAY !
Pareeeil
Vaiva lè france
I had to do the same. I'm Brazilian
@@chethan2668 dafuq
YESS me too... and i’m from Serbia 🇷🇸🤯
i just passed my biology daily test today about dna after i watched this yesterday night. I wanna give you a BIG thankyou for helping me study☺
it's also useful for MBBS Students
@@jayviews5375 These things are also taught in mbbs?
I thought it is only limited to school and then BSc at higher level
@@anshagrawal6289 Yes bro I'm now in 5th sem of MBBS...Its a part of Biochemistry
@@jayviews5375 Thank you for your information
not jungkook being everywhere i go ajhfaflfaf
I learnt DNA replication from ritu man seriously telling mam ki lecture ki baad animation ki jarurat nhi hote h pr m ne yeh dekha or bhi clear ho gaya❤️🔥why not school teacher teach like this ??? Fir bol te h bache nhi pdh te
Step 1: Helicase
Function: Helicase is the initial enzyme in DNA replication. Its primary function is to unwind the DNA
double helix. It accomplishes this by breaking the hydrogen bonds between the complementary base
pairs, such as A-T and G-C. By doing so, helicase separates the two DNA strands, creating what is called
a "replication fork." This single-stranded DNA region is where the actual replication process will take
place.
Step 2: Primase
Function: Primase follows helicase. Its role is to synthesize RNA primers. Primase adds short RNA
sequences, known as primers, to the DNA template strands. These primers are essential because DNA
Polymerase, the enzyme responsible for adding new DNA nucleotides during replication, can only
extend an existing strand. On the leading strand, primase synthesizes a single RNA primer at the 5'
end, providing a starting point for DNA Polymerase.
Step 3: DNA Polymerase III
Function: DNA Polymerase III is the primary enzyme responsible for DNA synthesis during replication.
It adds nucleotides to the growing DNA strand. On the leading strand, DNA Polymerase III synthesizesthe new DNA strand in a continuous manner by extending from the 5' to 3' direction, using the parental
DNA strand as a template. This strand doesn't encounter the same challenges as the lagging strand,
which requires a more intricate process.
Step 4: Exonuclease
Function: Exonucleases come into play after DNA Polymerase III. Their function is to remove RNA
primers from the DNA template. Once the RNA primers are synthesized by primase, exonucleases
degrade them, creating gaps in the DNA strands. On the lagging strand, multiple RNA primers are
synthesized at different points along the template to provide starting points for DNA Polymerase.
Step 5: DNA Polymerase I
Function: DNA Polymerase I is an enzyme responsible for gap-filling. After the removal of RNA primers
by exonucleases, DNA Polymerase I replaces the RNA nucleotides with DNA nucleotides. On the lagging
strand, DNA Polymerase I works in a discontinuous manner, filling in the gaps created by the removal
of RNA primers and synthesizing short DNA fragments called Okazaki fragments.
Step 6: Ligase
Function: Ligase is the final enzyme involved in DNA replication. Its function is to seal the nicks or gaps
in the DNA backbone. It does so by catalyzing the formation of phosphodiester bonds between
adjacent nucleotides. On the lagging strand, ligase joins the Okazaki fragments together, ensuring the
integrity and continuity of the newly synthesized DNA strand.
In conclusion, DNA replication involves two strands: the leading strand, which is synthesized
continuously, and the lagging strand, which is synthesized discontinuously in Okazaki fragments.
Different enzymes work together to ensure the accurate replication of both strands, preserving genetic
information during cell division and ensuring the inheritance of genetic traits.
Isn't it Pol delta in Eucaryote model ?
Only video that's straight to the point and explicitly states all the steps .. THANK YOU!
Very nice vidio
Yet still my homework doesn't make sense because I believe my professor simply wants us all to fail!
Finally can understand how lagging strand is replicated. Thank you!
Ikr
you are a bot
Ikr
This 3 minutes video was more helpful than my madams 3 hours long class.
Failed to understood a single word there
Thanks!
This video is super good in helping visualize the entire replication process. Although I think there was slight oversight in the direction of the DNA strand because in the beginning of the vid, the top strand was labeled 5' on the left side and 3' on the right side, but when DNA polymerase was introduced, the top strand was suddenly 3' on the left side and 5' on the right side.
It's so interesting to know how our body is made so intricately and it functions in a way that is beyond anything that we would make artificially.
Yeah. That’s why I love biology
it seems that we were not created by accident. We are created by the All-Knowing One who created the universe
@@RASTstudio Allahu Akbar!
@@Qwertyuiop21554 MashaAllah, Assalamu Alaykum. I thought you were not muslim
@@RASTstudio Wa alaykum Assalam
I don't understand why teachers can't explain like this ; slow and straight to the point . All they do is draw a diagram ( totally not realistic ) and ask us to write notes . And we are like lol what just happened .
Not everyone has a gift to be a teacher...for being a good teacher you have to have empathy so you are able to imagine yourself walking in shoes of another person, therefore, you are able to explain things extremely well as you are imagining how they will perceive the given information.
They are dumboo
My teacher explained wayyy too many details which made us all confused . Single strand binding protein , increasing efficiency of dntp addition ,etc.
All gone over the head
@@bitoffbalance4021 Can relate, totally ....
@@chanikarkare727 are you in medical College now?
this just brings me back to life and makes me forget every "imperfection" I think I have
I'm so glad I speak English. Here in Brazil we have amazing teachers, but i'm a more visual student, so it's a lot easier to learn with 3d videos
Easily the best replication video I've seen to date, thank you. I don't understand why it's so difficult for professors to explain this in a simple step by step process. I get that it's a complex topic, but damn, just go step by step. Stop talking about random enzymes in no discernible order.
ikr
This was by far the best video I've seen of this. Straight and to the point, no annoying music, and simple visuals. Absolutely fantastic!
Amazing❣!!! You have nailed it in minutes. I love how you explained everything about DNA replication. It was perfectly matched with an animation that adds to the total presentation. Your video is fun to watch and easy to understand👏👏
this video made me understand the dna replication in a perfect way, the animation is amazing and made it easier to understand especially in the part where the replication is in the opposit direction it was hard to get it at first but after this video i found it actually so simple. thank you for this amazing explication, well done.
How on earth did someone discover this and all the details?
The Almighty Lord created us, and also wanted us to know.
Ya & we hv to study this boring topic 🙂
more than 100 years of scientific research by a lot of different people
Watson & Crick. Along with some help from The Almighty.
Its beyond our intellect to assume that!
The best replication animation i have seen yet, thanks a lot!
Someone said these are really simulations.
@@cjhepburn7406 wdym ?
congrats on ur graduation!!!!!
I am an Egyptian student at my third secondary school year and this video helped me to imagine and understand a topic in my curriculum.
Thanks a lot!
I love how the first strand replication process is very simple, while the second strand replication is 100x more complicated lol.
my mind is blown this is the 100th video ive watched tonight and it is the only one i understood god bless
Amazingme liking the pfp ;)
hobi says mumble tumble lol no
ARMY with science
Jiminah
Starsbless
Life is so perfect.
Life is no accidental explosion.
yep
Yeh
Life isn't perfect. Otherwise why does DNA polimerase make so many mistakes and some lead to detrimental mutations? Why do cells suddenly abnormally proliferate and create tumours? I'll tell you what. Life isn't perfect. It's _good enough_ . Good enough that it can survive and thrive, but never perfect. Contemplating upon life itself and its mechanisms does not warrant the immediate conclusion of "this is no accident" or "someone _must_ be behind this". I suggest you step out of your initial reaction which may be corrupted and actually think critically for a second.
TrEs 2b the fact that DNA can correct itself is fascinating. The fact that something this small yet so complicated can happen in every cell is fascinating. It is logical and scientific to look for the source of something (existence). Just because you have an opinion, doesn’t mean theirs is corrupted and not critical. Life is perfect because of its imperfections. Idk what I’m trying to say exactly, but don’t force ur opinion on others :)
Very helpful animation! Thanks for visually showing the difference between an RNA primer and an Okazaki fragment; that made it easier to understand.
th-cam.com/video/o2arW0LJpPw/w-d-xo.html
Watch this video to know the detailed mechanism of DNA replication
Absolutely a great video 😍 was unable to understand replication process but this animated video has put away my all confusion 👍
As a science teacher this is by far the best replication video out there. Thanks for the clear description!
Go to my youtube channel there you will get full explanation with animation.
I think that my biology teacher didn’t actually know how to explain this so he just resorted to this video lol
Same here!
Same here
Why not
same lmao
Look at the bright side: at least he has self-critique. I'm re-learning biology over a decade after leaving high school, cause I was always interested in it, it's just all my teachers were... Bad. lol
This video is so wonderfully helpful. I was struggling thru diagrams in the text trying to get all the weird terms to stick and this is exactly what I needed to see and how I needed it explained. Thants!
Fantastic explanation...every time before my exams I use to watch this video for better clarity...
Best video ever to show DNA replication! No other video that I could find really explains in a short but well detailed manner. Other videos I feel are for those who are already familiar with the process. This is my first year learning this process and I'm grateful I found this video!!
This was very helpful, I've been studying this for a few days now but I've always had a fuzzy picture of how the lagging strand is formed. Your video cleared everything up. Thank you!
Very easy to understand whole process of DNA replication through this video...thanks a lot😊
This is the best explanation I could've ever got for DNA Replication🔥🔥🔥🔥
After 20 minutes of watching videos and re-watching them, this one did the most at helping me understand the process.
The old but gold DNA replication 😁 This is so inspirational. Thank you so much, It helps a lot in learning, but also revising.
The best guidance for DNA replication and anyone can understand smoothly...Thank you
One of the best videos on the internet, so underrated
As a 3D artist, I feel it’s awesome to see these types of animations being used in education. Keep up the great work!
anyone with an exclamation mark is scripted
@@abdulrahmanalghothani3911 amen to that
Aww wow, it's so helpful
한국어 자막 달아주신분 감사합니다 덕분에 잘 공부하고 갑니다
Sábias palavras
^^도움이 되셨다니 다행입니다~
Simple explanation. Beautiful animation. I couldn't possibly wrap my mind around this Okazaki business before I watched this.
Anyone here because they're gonna turn spiderman with a new experimented dose of spider genome lol
Just u eren
Excellent animation.
I wished it showed how topoisomerase did it's work in separating the overcoiled knots of daughter DNA strands.
Just imagine it doing what helicase is
It breaks, swivels and rearranges DNA to release tension made by action of helicase
정말정말정말 감사합니다
Thank you sooo much 자막 달아주신분두요ㅜㅜ
This should be shown by every bio teachers to their students. It really clears some doubts!!
My professor litearlly took 8 lessons to explain this process and almost nobody got it, it’s way simpler than I thought thank you
Wow you are a life safer. Thank you so much. This animation should be shown in every biology class on this topic.
Edit: I suggested it to my teacher. It might have an impact. Good job!!!
This is sooooo amazing with 3d visualisation I have chills when watching this... Gonna watch 9-10 times probably to remember it better...
I'm in my senior year of high school. I'm learning protein synthesis and DNA replication. I really like this animation, it's great to have universal scientific facts even in a different language! My teacher's voice echoes in my mind
Lol i became freshmen and am also learning this
@@saintshiroo highschool or university?
@@yoonoh23 highschool
@@saintshiroo which country
@@yoonoh23 USA
Yep this three minutes video somehow explains the topic better than my teacher on an 1h lecture.......
Short and concise! Best explanation I found so far on the internet. It also shows how easy it is for this process to make small mistakes hereby distorting the DNA replication process with all the consequences that follow.
Biology teachers should learn how to teach replication and some other topics soo easily as in this video.
Finally I understood Replication with the help of this video. Thanks a lot 👍👍👏👏😊😊
it’s because visuals/animations are much better at helping you understand scientific processes like dna replication than just explaining it in words. it makes a blurred picture much more clearer.
Beautiful. I am in love with these videos. So easy to understand for a concept I have been struggling to understand for a long time. A big thank you to the one who took pains to make this video. Please keep providing students with such useful concepts in easy form.
As a IB student I was desperately looking for this kind of video, thank you very much!
Out of all the DNA replication videos this one is so good, very detailed and easy to understand thank you
I must say, for the very first time I can really understand what DNA replication is all about....
Thanks a lot for such a amazing video
Wow, what an amazing video! Incredible animation of this complicated process...helped me a lot with my schoolwork.
Thank you 😭😭😭😭😭.....
I never understand these concepts but after watching this I can teach this concepts to another person's 😊
can't believe i haven't found this earlier after so much of my time wasted trying to look for a simple explanation like this. thank you so much i finally understand it.
this is so magical that i can’t stop rewatching
nereyi kazandın ?
As a matric student writing my final biology paper tomorrow these videos have literally saved my life at this point😭 thank you so much🙏
The best genetics video I've watched so far
This is one of the best videos for explaining DNA replication, thank you!
Such a short clip is worth more than a thousand books.
Thank you so much, I had to learn for my biology exam today and this video made things al lot easier to understand!!
Simple and comprehensive video .. At first I thought it was an obscure concept , but after watching this video I got it...
One of the most helpful video I've ever seen. Thanks for it.
My life I must be a visual learner this is the first time i have ever had a clue about the lagging strand
Best and easy way to understand and better than protracted videos
My god this 3 minute video single handedly gets me though the exam. Thank you so so much for ever making this video.
Extremely helpful! You have done a wonderful job. Thanks a lot.
god bless the maker of this video.Finally I have understood the process of DNA replication. Its really Owsome!
owsome realy
thank you for doing this - from a Vietnamese student at high school.
I said it and repeat : It's the best type of explanation ever.
Thank you very much!
very simple explanation. I used this video for my genetics exam and it was very useful
Anyone else here because the teacher suggested this video 😂😂
Nope , randomly
Me
Hannn💀
Yeah same
Yes.. 😊😊
Thanks for explaining this complex mechanism so beautifully
one of the best videos on TH-cam NO CAP
You are the best teacher , kudos
What took Biology 12 between 3 - 4 weeks to explain, explained in 3 minutes. All I’ve got to say
then you're clearly not paying attention in class because let me tell ya bud, this is not all that is discussed in biology. not even close actually.
Perfectly summarises everything.
This video single handily helped me finally understand the process.
DNA REPLICATION (semi-conservative bc each DNA molecule is made up of one old, conserved strand of DNA):
1 - separation of 2 strands (unzipping done by helicase, result: replication fork)
2 - separated strands provide template to create new strand of DNA (started by primase, which creates a piece of RNA called primer --- this is the starting point of the new strand of DNA)
3 - DNA polymerase binds to the primer and adds bases from 5' to 3' (in the leading strand). on the other hand in the lagging strand, DNA polymerase adds bases in a series of small chunks called the okazaki fragments
4 - once the DNA has been made, exonuclease removes all RNA primers from both strands of DNA
5 - another DNA polymerase fills the gaps that are left behind with DNA
6 - DNA ligase seals up the fragments of DNA in both strands to form a continuous double strand
Finally I'll be visualize the process of DNA replication
Thank you so much . I'm a A/l biology student in sri lanka 🇱🇰
This video is very helpful to me 🙏
For the very first time, I understand the okazaki fragment clearly through this video :').. Thank you so much.