Pharmacology - ANTIPSYCHOTICS (MADE EASY)
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- เผยแพร่เมื่อ 4 มิ.ย. 2024
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Antipsychotics, also known as neuroleptics, are a class of drugs used to treat psychiatric disorders, such as schizophrenia, bipolar disorder, and psychotic depression. Antipsychotics work by changing the way certain neurotransmitters (mainly dopamine) act in the brain. This pharmacology lecture covers topics such as schizophrenia, role of dopamine in the development of psychosis, dopamine pathways in the brain (Mesolimbic, Mesocortical, Nigrostriatal, Tuberoinfundibular), positive & negative symptoms of schizophrenia, dopamine & serotonin receptors, mechanism of action and side effects of antipsychotic drugs (1st generation typical & 2nd generation atypical). Drugs mentioned include; Haloperidol, Fluphenazine, Prochlorperazine, Trifluoperazine, Chlorpromazine, Aripiprazole, Clozapine, Lurasidone, Olanzapine, Quetiapine, Risperidone, and Ziprasidone.
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0:00 Intro
0:43 Dopaminergic pathways
1:56 Dopamine receptors
2:40 First-generation 'typical' antipsychotics
5:26 Second-generation 'atypical' antipsychotics
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I literally wasted 2 hours reading book before watching this video... I read my book after watching, I understood everything.
Same man. This video was wonderful.
😂 great iam too
Add a sticky note in the book with the link that would be awesome
Same here
Sameeee
Dude you are so amazing! You have no idea how much your videos have helped me as a pharmacy student. It has made pharmacology so simple. You deserved every good thing on this earth. Much love❤
Amen!!!
The Health System is Genius!
th-cam.com/video/-Nd40Uy6tbQ/w-d-xo.html
Not a student, just trying to educate myself on antipsychotics after being prescribed for a few years, I had psychosis. Currently weaning off of olanzapine.
I'm on risperidone after psychosis in 2018 and 2019. I lowered my dose from 4 to 1 mg over the past 1.5 years. How's it going with you so far weaning off the olanzapine?
How are you doing? I've been on olanzapine for a couple years too. I'm trying to get off as well
Awesome that you are weaning off, I currently have minor form of PTSD, self diagnosed, and have been prescribed olanzapine, methex od etc.
@@rockit5288 you lowered your dose, or you and your health care provider worked together to lower your dose?
Yeayy, congrats. Hope you'll be okay!!
I'm a student nurse, and this has made it so much easier than everything I've read!!
The Health System is Genius!
th-cam.com/video/-Nd40Uy6tbQ/w-d-xo.html
What a elaboration in just 8 minutes. You have cleared many concepts. Thanks a lot.
Thank you for this simplified lecture. I watch your videos before reading textbooks or materials and it's always an easy read for me. Much love from Nigeria.
perfect timing....i dont usually subscribe to channels, but when i do, its speed pharmacology ...keep it up.. thank you for your work....youre a beast
My negative effect ba ang nozinan sa sperm cell
Finally I can inform my pd whats going on inside my head on a molecular level. Thank you so much.
my life was for a long time ruined by antipsychotics. was prescribed them and although I suffer from major depressive disorder, I do not have schizophrenia, bipolar, or any sort of mood disorder. Because I already lack serotonin and dopamime due to my depression, this medication sedated me/turned me into a zombie, made me gain 15 lbs in a matter of 2 weeks, stripped me of my personality, confidence and creativity, & even after I went off of them, I could not get back to the girl I was before. I no longer was responding to any antidepressants that had worked in earlier years or stimulant medication that had helped in the past. I looked awful and became a different person. All I wanted to do was sleep. I was so severely depressed i could not function at work (yes, I was trying every class of antidepressants at this point). I was no longer myself and had become completely overcome by my mental illness. It got so bad that my therapist insisted I seek more comprehensive medical treatment. I admitted myself to the hospital and after many more trials of medications, I had to resort to electroconvulsive therapy. I am 23 years old. Although it has a terrible rep, this treatment saved my life. the reason I am writing this here is because I think antipsychotic medications are necessary for people who naturally go into manic states, suffer from schizophrenia or psychosis. however, I am writing this as an informative warning that these medications WILL change you, and WILL sedate you. for some this is necessary. however, if you are prescribed these because antidepressants alone are failing, I really hope you will do the research on how they work because I believe that for a depressed person, these meds can be extremely detrimental . I hope that those who need these meds find them helpful. However, for me the damage they did could only be repaired by literally shocking my brain out of it. Good luck to all and please know YOU ARE NOT ALONE.
Gracie xx thank you so much for telling us the truth..my friend is on aripiprazole for bipolar and she has been acting weird lately...i don't know how to handle the situation...now i ll just show your comment to her and maybe it ll help her get better
@@sanagoyal4119 can you tell me about electrocolvulsive thearpy?
@@sanagoyal4119 CAN you tell me,please,do they really work?
@@sanagoyal4119 becsuse my daughtersuddenely starting talking with herself and they prescribe her first Aripiprazole and now they put her on olanzapine,so plesse tell me,psychiatrist doctor snd nurses giving me lots of hope...can you tell me please?..Do these medicine really work?
@@sanagoyal4119 if they don't work,then what other treatment are possible?
YOUR VIDEOS ARE AMAZING! please post for every drug, i learn so much just by watching these short clips. THANK YOU!!! :)
I imagine if they did that it might be a few years before they finished posting….!!
I love you man. This is how one man helps another😘😁
I must admit, this is a great video. You have allowed my brain to gain weight on neuroleptic and for that I’m grateful 🙏🏻
Thanks for the quality of this video, and the concise, clear way these mechanisms are affecting us potentially! You are making it interesting both for patients and also purely on an intellectual and educational levels!
The Health System is Genius!
th-cam.com/video/-Nd40Uy6tbQ/w-d-xo.html
"patients" uhm i guess the word ur looking for is lab rat ....?
من هذه اللحظة لن اضيع بعد الان اي لحظة في غير الطب والعلم و العبادة
والان ماذا حدث بعد 4 سنوات 🤔
Dude, your style of concept presentation is awesome. Keep up the great work!
Excellent explanation!! simple and easy graphics made to understand! As a psychology student, studying Schizophrenia this just made my day a whole lot easier! Thank you!
That was so simple even I could understand it. Thanks a loooooooot !
appreciate you stringing the neurotransmitters, pathways, and side effects. Very helpful! Thanks!
You are a legend. Words cannot describe how helpful and informative your videos are. They have been my saviors. God bless you! You deserve to be known and awarded for your concise knowledge!! 🤩
Agreed 100 %
Thank you for such a clear explanation on this topic!
a perfect explanation of how cures could be worse than the disease
Definatley.
Is torture the reason for These devasting side effects. Why ja this called help?
@@clausmehl8731 it's considered "treatment" to make people so ill that they are driven to their death.
@@FutureBoyWonder I'm still right 😏
Chemical lobotomizers*
Thanks a lot for this very clear lecture! Keep up the good work!
This was a very helpful video. Detailed however engaging. I have learned a lot in under 10 minutes 👏🏾 now I will study this so it sticks
Amazing video, this helped me understand the information so much more. Thank you!!
Thank You. This is exactly what I was looking for. I was wondering exactly how my medication actually works on my brain and I couldn't find it. Until now.
The Health System is Genius!
th-cam.com/video/-Nd40Uy6tbQ/w-d-xo.html
Great stuff. so simple and straight forward. thanks a lot.
Love this-you made it very easy to understand what it’s doing to my brain 🧠
@Ken Personal LOL
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Thanks alot sir🥰❤ you accomplished what my teacher couldn't do in 3 hours, in just 8 minutes. THANK YOU
I was misdiagnosed with schizophrenia. Been drug free for a long time and I am still suffering the disabilities caused by these medications. I cant express emotion and have slurred speach. The eay I walk changed. My hormones are all over the place. I exercise and hope for a better future. I feel like my a bird shose wings been clipped.
What drug was that and how long since you stopped?
Thanks for making it simple, I really understand it now. 👌🏽
Thank you so much, I was mixing my medications and your concise and clear way of explaining has helped me very much. I am new to your channel just subscribed.. Great explaining.
Thank you so very kindly for this video, you have no idea how much I personally appreciate it.
EXCELLENT video that helped with review!! Thank you!!
You clear my 5 yrs phobia of antipsychotics with single 8 min video.thank a lot🙂
thanks for the quality and highly educative video. i love it
Informative. Thank you. You really made this topic easier
Thank you so much for this absolutely brilliant video!!
Most people will never experience extrapyramidal symptoms (EPS) so they have no idea how horrible they can be. There are many factors contributing to EPS but mainly a dysfunctional dopaminergic and acetylcholinergic neurological system play a role.
There are so many hyperkinetic movement disorders like dystonia, dyskinesia, akinesia, akathisia, athetosis, ataxia, chorea, myoclonus, ballismus, tics, tremors, Tourette’s, spasms, RLS,etc.. it can make it very hard to distinguish.
I sympathize for schizophrenics and people who need certain antipsychotics and other medications that exacerbate these movement disorders. Most these medications drastically deplete Dopamine which is one of the main reasons for these extrapyramidal side effects.
Science has had more than enough time AND MZoNEY to develop a novel medication that should not cause this. Many schizophrenics need glutamate and dopamine regulation (not always “reduction”). There are several dopaminergic receptors and binding sites that can be antagonized and agonized therefore there is ZERO reason why there isn’t a proper neuroleptic to control psychiatric side effects while not exacerbating extrapyramidal side effects OR anhedonia!
Dopamine agonists can do wonders for EPS and science was able to develop non-ergot agonists which are much much safer yet can’t develop an agonist that will not cause debilitating Dopamine withdrawl Syndrome? Come on that is ridiculousness there is no excuse for no development of one. Or how about an MAOI with no withdrawal? Nope, doesn’t exist 🤦♂️
9-Methyl-β-carboline should be further examined as it appears to have incredible dopaminergic restoration properties. A study was done on rats that proved it. In layman’s terms scientists injected rats with synthetic neurotoxic compounds like 2,4,5-trihydroxyphenethylamine (6-OHDA) and 1-methyl-4-phenyl-pyridinium ion (MPP+) that selectively destroy tyrosine hydroxylase and dopaminergic neurons. So they essentially gave these rats Parkinson’s like symptoms.
After a few weeks of 9-Methyl-β-carboline administration around 80% of the damaged neurons returned to normal determined by measurements of nicotinamide adenine dinucleotide dehydrogenase activity.
Also the adamantane derivative called Bromantane and Pentadecapeptide BPC-157 play important roles.
Yet no ongoing research is being done. 🤦♂️
Sorry for my english ...
YOU Are SAYING that IT is POSSIBLE have an anti psychotic without side effects ??? Allucination depends ON high nonormal levels of dopamine in the BRAIN ??
These videos are so helpful...you´re far better at explaining pharmacology than any of my college teachers!! You make it seem easy and cool.Thank you so much from Spain!!
Thanks a lot. This video is the best among others that I have watched to understand the mechanism of action of the drugs.
thank you so much...enjoyed it indeed. i believe i can hammer any question on anti-psychotics on my exam next week.
Nice video. I like the fact that you went into specific dopamine receptor selectivity and the different dopaminergic pathways that can be implicated. Subscribed to your channel. :)
Wonderful! Thank you so much!
Thanks a lot.
You are really telling all the things in effective manner ,it is easy to understang and goes to long term memory .
Great work!
The Health System is Genius!
th-cam.com/video/-Nd40Uy6tbQ/w-d-xo.html
thanks for this but just to note a MAJOR correction: psychosis is associated with increased dopamine presynaptic function in the nigrostriatal pathway (particularly the part that projects to the associative subdivision of the striatum) it is NOT the mesolimbic system
It was so nice and simplified.Now when I read the book it will all make sense. Thank you
AMAZING video!! So clear and engaging. Thank you!
Absolutely love it .BRAVO
Came to understand Quetiapine’s mechanism of action. I understand it now!! Thank you!
this video is pure gold! thank you so much
Excellent content ...so precise and comprehensive ....you should make videos on all topics
Wow new favourite channel. So bummed I’m only finding it now!
I am an avid #MentalHealthAwareness advocate and performer, and I love this so much. I travel the country trying to bring that awareness on stages, in classrooms, hospitals, and on my TH-cam channel, so I get excited when I see other advocates. 💙❤
So very true nice 👍🏻
Thank you! This video was very helpful.
I was searching for this information. Thank you, it's amazing 🤩
Excellent presentation, your work is appreciated worldwide
Sir ur videos are simply amazing and ur way of teaching through animations is best
CNS pharmacology will never be such easier without ur lectures
keep going and best of luck
The Health System is Genius!
th-cam.com/video/-Nd40Uy6tbQ/w-d-xo.html
And these are supposed to help people? Amazing, truly amazing. With friends like this, who needs enemies.
such an amazing video...thank you. Much appreciated!!!!
Thanks for the video. Great help for 3rd year medical studies in Germany
Remember 'Antipsychotics' can be 'hyperbolic' - which means that withdrawal needs to be approached more carefully at reduced doses.
And remember that abrupt 'antipsychotic' drug withdrawal can result in 'Withdrawal Psychosis'.
love your channel. please keep making more videos!
Just wanted to say you r the best human I learned so much for my exam tomz shout out to you sir you have saved my life amen
Many thanks to you. I have gained a lot of knowledge just watching this video. Hope you I video on the serotonin pathway. God bless you
Thanks a lot!
Videos are awesome with a great and easy illustration
Thanks again :)
Very much helpful and time-befitting
Thank you so much. This was extremely helpful.
Thanks a lot for wonderful summary !!! 👍
very easy to understand and relate the concepts, well done mate!
Thanks, helpful, well illustrated video!
Extremely well explained and thanks
you are sent from heaven!!!thank you so much!
Great explanation, thank you
Best explanation of antipsychotics so far 👍🏽👍🏽👍🏽
this is an amazing video! Thank you so much !
I love you man, you took pharma out of nightmare's list. big thanks
Thank you very much ❤️
Clear and comprehensive review, thank u
Your videos are amazing and easy to understand but could you also add mnemonics.it will really help us to retain the drug names in our memory for longer period of time ✌️✌️😁
Time saving , thanks alot 💙❤
thank you for making pharmacology easy!
so helpful. thank you so much
Thank you so much. I really needed this. Doctors never reach anything. Congratulations.
Awesome job!🙂
Thank you very useful information. Wish i watched this 15 years ago.
Great video!! Thank you!
Excellent work sir thank you so much ❤️
Thank you so much!
Thank you that’s really was helpful
That was very fun to watch.
Excellent 👍👍👍
Best video ever I found on TH-cam
Thanks a lot for the video!
wish i found your videos sooner!! please make a video about antiepileptics or drugs for parkinson's disease :)
Varporic acid for elispy
Informative. Thank you
Great video on antipsychotic medications. Thanks for sharing
I think the APs causing onset or worsening of negative symptoms is called “Neuroleptic-induced deficit syndrome”. I feel like this is something that needs to be talked more about!
Dude I love you. You have a gift for teaching
Thanks. Super good!
Great video, thanks a lot