10. Metabolism of sulfur containing AA- Methionine, Cysteine and Cystine

Steps
1. Conversion of methionine to homocysteine
2. Cysteine formation
3. Degradation of cysteine- formation of coA, sulfate, taurine, pyruvate etc.

[@reine2212]

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[@Rajesh_Jambhulkar]

Best luck dear, be confident

[@reine2212]

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[@Abeeer-tk8ln]

All of my friends including me watch your videos for Biochem Sir❤️ Thanks for all your effort in doing this. These classes mean alot to us.

[@sgtaneja]

Well presented !
I believe active methylated forms of B6 - P5P, folate - 5MTHF, B12 - methylcobalamin along with free form Glycine and Methionine are critical for driving folate, methionine & transulfuration pathways.
Note : Serine can be derived from Glycine and vice-versa in the 1C metabolism.
Methionine is a critical precursor for biologically vital molecules SAMe, cysteine, taurine, and GSH.
Methionine compounds with zinc & selenium are also clinically relevant.
Methionine is also a precursor for synthesis of creatine, and carnitine.
SAMe is super critical for methylation of DNA, proteins, neurotransmitters, NE, PC, SR, and for supporting methyltransferases.
Cysteine is critical for GSH (rate limiting) along with Glycine.
Cysteine zinc proteins are vital and used for transcription, while cysteine seleno proteins are used in detox pathways.
However, Cystine (not cysteine) can spur reactive nitrogen & oxygen species.
Taurine is vital not only for bile salt synthesis (along with Glycine), it is critical for redox balance - its an antioxidant. Note the cysteine metabolism can also generate sulfites which are toxic if not conveted to sulfates. This process requires molybdenum and sulfite accumulation is common is people with MoCo - molybdenum cofactor deficiency.
Note2 : Having NAC is NOT equivalent to upregulating intracellular GSH bcoz GSH synthesis requires several cofactors including methionine/cysteine, glycine, glutamate, selenium, magnesium, B6, B2, B3, heme (glycine), vit C (redox cycling). It also is dependent of GCLC gene and many folks have mutation of GCLC.

[@zainabfatima8858]

Sir you are amazing..u are making this subject soo easy to study

[@livebiochemistry]

Cysteinuria - defective transport of cysteine along with ornithine lysines and arginine
While in cystinosis -cystine reductase deficient lead to accumulation of "cystine"

[@teamxcolt5655]

These classes are best understanding the topic as well as for scoring marks
🙏 Thank u sir

[@apratimdebnath77075]

TRUE

[@drkapilyogi478]

thank you sir for this great information

[@sandya874]

That was so clear and concise sir, Thankyou

[@yogenderahlawat4692]

amazing video sir

[@DrArafath]

Thank you sir 😊👌

[@lalithakt4418]

2 hours before exam 😗🫠
Update : class was literally superb.
As I studied in the last moment, could not recall what I lernt failed the internals 🫠🥲

[@mayapatidar3543]

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.✌🖤🌻

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Badhiyaaaaa!!!

[@jimw.8030]

A very good morning Doctor
I can't get enough of your chanel
Keep up the good work

[@deepanshu5341]

Your video lectures solve all my doubts, thank you sir

[@HarendraKumar-qj3pj]

Thank you sir🙏🙏

[@awanishranjan8332]

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[@ahmedsaleem5357]

Sir God bless you.... 😭❤️

[@hinariaz2302]

Amazing

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This is great 👍 excellent job. 👏

[@bublisoniyak6227]

Thank you sir 🔥🙏

[@yazi.7410]

Thank you sir🙏😀

[@darshitmal9644]

Thank you sir

[@Ankit.malyaj]

Thank you so much sir 🙏🙏❤❤

[@PramodKumar-wp4wr]

Thanks sir🙏

[@KUMARAditya25]

Thank u sir 🙏🏻💚💜

[@gargikadu7071]

Thanks sir

[@vikkod2270]

To supplement Methionine, do we need to work on vitamin B’s first ?

[@022chanakya9]

Tq u very much sir

[@lekkalanaidu5071]

Tqq soo much sir

[@saadahmad6250]

Great work sir 👍

[@annuzintatom1893]

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[@mohammedq.hussain7976]

Plasma homocysteine levels are inversely related to plasma levels of folate, B12, and B6???

[@faraazsinghsandhu7178]

No one can replace you

[@mythili7319]

Thank u sir

[@kattemamatha18]

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[@satishdhawan5408]

Very nice explanation sir...tq so much sir

[@sandeepchoudhary7855]

🔥🔥🔥

[@addakulashyam6230]

Sir is methionine synthase and homocysteine transferase are same?

[@gowthami8968]

Thank you so much sir.
Very useful videos sir

[@shashanktp6362]

Sir you did not mention about glutathione synthesis??

[@TheBestWeddingMusic]

Hi. Are these 3 amino acids depend on sulfur ? I can’t eat sulfur foods and B6. I believe my cysteine levels are not in balance but I don’t understand how it all works. I can’t take mo-Zyme forte it cause pain. What reaction is happening there and can you share any links where I can learn more about this? I don’t understand the role of glutamine and glycine. Also the meaning of methionine to cysteine recycling and methionine biosynthesis. Thanks

[@TheBestWeddingMusic]

How selenium plays role in this process to glutathione?

[@padminisahu153]

Sir Homocysteine is essential or non- essential amino acid??

[@CortexMatrix]

7:50 sir textbook says Cysteine and à ketobutyrate are formed instead of homoserine.
Plz clarify

[@60.praveenkumarp25]

Same doubt

[@applestone5812]

@@60.praveenkumarp25 can you suggest a text book for this topic please

[@60.praveenkumarp25]

@@applestone5812 vasudevan

[@SID-nr4lz]

cysteine and homoserine are formed and from homoserine u get a-ketobutyrate then propionyl then succinyl then glucose

[@nitinsur1]

How to calculate methionine cysteine ratio in poultry feed

[@Avinash12988]

❤❤❤

[@MuhammadIbrahim-jf4ix]

Sir structure be sath main banao na

[@usmanghazanfar3544]

Thanks sir for best explanation

[@user-dp5te6oi9p]

Sir cysteine dioxygenase likha hnn kyu middle ma

[@sasankamandi6713]

💥👍

[@rentoquando5249]

Sir i take supplements n acetyl cystein en trimethilglisin. You think is safe ? Or you dont recommend this

[@debasmitde8801]

Which country you are from ?

[@rentoquando5249]

@@debasmitde8801 why?

[@03abdulsameerpatel91]

Sir upload glycine metabolism

[@Rajesh_Jambhulkar]

Uploaded, thanks

[@03abdulsameerpatel91]

Thanks sir .

[@ujefmakwana5070]

Pls add subtitles for better experience 😀😀😀...

[@shubhamtornekar3740]

Sir instead of homoserine can we take Alpha ketobutyrate so that we can add metabolism of leucine and threonine?

[@bilawalsohrani1135]

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[@wallflovr]

Cystothianine gives cysteine and ketoglutaric acid

[@subodhrana3214]

Good morning sir

[@karishmakhubchandani545]

Sir can you please discuss on aromatic amino acid metabolism..

[@alicep.morris8977]

My son has been diagnosed with this rare sulfur blood born problem. He is in hospital now but the doctors know nothing about it. They are trying to research and problem solve. Is there a doctor out there that has worked with this. My son has had TBI Please help

[@Rajesh_Jambhulkar]

Plz refer to higher centres for follow up and treatment. ( Mumbai, Delhi, Bangalore, chennai) or any metro City near to u.

[@aryasharma3360]

Sir metabolic acidosis and alkalosis ka video banadijiye

[@Rajesh_Jambhulkar]

Sure,
Will take time

[@hemachowdary2430]

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[@fatimaarshad5802]

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[@kevinken2576]

oh

[@anitameena3212]

Sir aap kon si book preferre kar to ho

[@Rajesh_Jambhulkar]

DM Vasudevan for UG

[@saranyasaa8046]

Sir , could you please provide pdf note for each topic 🙏

[@RanaRana-px8jd]

8:48 you said here that the cysteine have a sulfur from methionine and the rest of the molecule is from the serine !what is the rest of the molecule you mean homoserine!!!

[@phyllisbotchway6796]

the remaining molecular structure of cyteine i think

[@anitameena3212]

Replay plz.. sir

[@60.praveenkumarp25]

Thank you sir

[@43hermafathima65]

Thankyou so much sir❤️

[@shubhamaggarwal3801]

Thank you sir