10. Metabolism of sulfur containing AA- Methionine, Cysteine and Cystine

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  • เผยแพร่เมื่อ 5 ก.พ. 2019
  • Steps
    1. Conversion of methionine to homocysteine
    2. Cysteine formation
    3. Degradation of cysteine- formation of coA, sulfate, taurine, pyruvate etc.

ความคิดเห็น • 88

  • @reine2212
    @reine2212 3 หลายเดือนก่อน +6

    I had zero hopes of passing my terms but now I am feeling like I can pass, after watching your videos

    • @Rajesh_Jambhulkar
      @Rajesh_Jambhulkar  3 หลายเดือนก่อน

      Best luck dear, be confident

    • @reine2212
      @reine2212 3 หลายเดือนก่อน

      @@Rajesh_Jambhulkar thank you so much sir🙏🙏🙏

  • @Abeeer-tk8ln
    @Abeeer-tk8ln 3 ปีที่แล้ว +36

    All of my friends including me watch your videos for Biochem Sir❤️ Thanks for all your effort in doing this. These classes mean alot to us.

  • @sgtaneja
    @sgtaneja 25 วันที่ผ่านมา +1

    Well presented !
    I believe active methylated forms of B6 - P5P, folate - 5MTHF, B12 - methylcobalamin along with free form Glycine and Methionine are critical for driving folate, methionine & transulfuration pathways.
    Note : Serine can be derived from Glycine and vice-versa in the 1C metabolism.
    Methionine is a critical precursor for biologically vital molecules SAMe, cysteine, taurine, and GSH.
    Methionine compounds with zinc & selenium are also clinically relevant.
    Methionine is also a precursor for synthesis of creatine, and carnitine.
    SAMe is super critical for methylation of DNA, proteins, neurotransmitters, NE, PC, SR, and for supporting methyltransferases.
    Cysteine is critical for GSH (rate limiting) along with Glycine.
    Cysteine zinc proteins are vital and used for transcription, while cysteine seleno proteins are used in detox pathways.
    However, Cystine (not cysteine) can spur reactive nitrogen & oxygen species.
    Taurine is vital not only for bile salt synthesis (along with Glycine), it is critical for redox balance - its an antioxidant. Note the cysteine metabolism can also generate sulfites which are toxic if not conveted to sulfates. This process requires molybdenum and sulfite accumulation is common is people with MoCo - molybdenum cofactor deficiency.
    Note2 : Having NAC is NOT equivalent to upregulating intracellular GSH bcoz GSH synthesis requires several cofactors including methionine/cysteine, glycine, glutamate, selenium, magnesium, B6, B2, B3, heme (glycine), vit C (redox cycling). It also is dependent of GCLC gene and many folks have mutation of GCLC.

  • @zainabfatima8858
    @zainabfatima8858 3 ปีที่แล้ว +23

    Sir you are amazing..u are making this subject soo easy to study

  • @livebiochemistry
    @livebiochemistry 4 ปีที่แล้ว +21

    Cysteinuria - defective transport of cysteine along with ornithine lysines and arginine
    While in cystinosis -cystine reductase deficient lead to accumulation of "cystine"

  • @teamxcolt5655
    @teamxcolt5655 2 ปีที่แล้ว +16

    These classes are best understanding the topic as well as for scoring marks
    🙏 Thank u sir

  • @jimw.8030
    @jimw.8030 2 ปีที่แล้ว +3

    A very good morning Doctor
    I can't get enough of your chanel
    Keep up the good work

  • @awanishranjan8332
    @awanishranjan8332 3 ปีที่แล้ว +7

    Thnku alot sir,for ur great support,iam totally impressed with uu..all video of biochem i reffered from u😌😌😌

  • @drkapilyogi478
    @drkapilyogi478 4 ปีที่แล้ว +2

    thank you sir for this great information

  • @sandya874
    @sandya874 3 ปีที่แล้ว +9

    That was so clear and concise sir, Thankyou

  • @lalithakt4418
    @lalithakt4418 3 หลายเดือนก่อน +2

    2 hours before exam 😗🫠
    Update : class was literally superb.
    As I studied in the last moment, could not recall what I lernt failed the internals 🫠🥲

  • @deepanshu5341
    @deepanshu5341 3 ปีที่แล้ว +3

    Your video lectures solve all my doubts, thank you sir

  • @yogenderahlawat4692
    @yogenderahlawat4692 4 ปีที่แล้ว +1

    amazing video sir

  • @DrArafath
    @DrArafath 5 ปีที่แล้ว +5

    Thank you sir 😊👌

  • @mayapatidar3543
    @mayapatidar3543 5 ปีที่แล้ว +2

    Thnx a lot sir
    .✌🖤🌻

  • @kattemamatha18
    @kattemamatha18 3 ปีที่แล้ว +2

    Tq tq tq so much Sir u r doing good job Sir because i fell biochemistry subject is very Hard but when i started to see ur video it make me very easssy Sir tq Sir number of students r waiting for ur viodes Sir we r blessed Sir

  • @HarendraKumar-qj3pj
    @HarendraKumar-qj3pj 3 ปีที่แล้ว +2

    Thank you sir🙏🙏

  • @ahmedsaleem5357
    @ahmedsaleem5357 2 ปีที่แล้ว +4

    Sir God bless you.... 😭❤️

  • @bipprojr5269
    @bipprojr5269 3 ปีที่แล้ว +1

    Badhiyaaaaa!!!

  • @vikkod2270
    @vikkod2270 2 ปีที่แล้ว +1

    To supplement Methionine, do we need to work on vitamin B’s first ?

  • @jesseacers8655
    @jesseacers8655 2 ปีที่แล้ว +3

    This is great 👍 excellent job. 👏

  • @hinariaz2302
    @hinariaz2302 ปีที่แล้ว

    Amazing

  • @Ankit.malyaj
    @Ankit.malyaj 9 หลายเดือนก่อน

    Thank you so much sir 🙏🙏❤❤

  • @darshitmal9644
    @darshitmal9644 4 ปีที่แล้ว +1

    Thank you sir

  • @yazi.7410
    @yazi.7410 ปีที่แล้ว +1

    Thank you sir🙏😀

  • @bublisoniyak6227
    @bublisoniyak6227 2 ปีที่แล้ว

    Thank you sir 🔥🙏

  • @faraazsinghsandhu7178
    @faraazsinghsandhu7178 4 หลายเดือนก่อน

    No one can replace you

  • @mohammedq.hussain7976
    @mohammedq.hussain7976 4 ปีที่แล้ว +2

    Plasma homocysteine levels are inversely related to plasma levels of folate, B12, and B6???

  • @KUMARAditya25
    @KUMARAditya25 3 ปีที่แล้ว +1

    Thank u sir 🙏🏻💚💜

  • @PramodKumar-wp4wr
    @PramodKumar-wp4wr 4 ปีที่แล้ว +1

    Thanks sir🙏

  • @annuzintatom1893
    @annuzintatom1893 2 ปีที่แล้ว +3

    Thank you so much sir for your classes 💖

  • @gargikadu7071
    @gargikadu7071 3 ปีที่แล้ว +2

    Thanks sir

  • @lekkalanaidu5071
    @lekkalanaidu5071 3 ปีที่แล้ว +1

    Tqq soo much sir

  • @022chanakya9
    @022chanakya9 3 ปีที่แล้ว +1

    Tq u very much sir

  • @sandeepchoudhary7855
    @sandeepchoudhary7855 2 ปีที่แล้ว +1

    🔥🔥🔥

  • @saadahmad6250
    @saadahmad6250 5 ปีที่แล้ว +3

    Great work sir 👍

  • @mythili7319
    @mythili7319 2 ปีที่แล้ว +1

    Thank u sir

  • @addakulashyam6230
    @addakulashyam6230 2 ปีที่แล้ว

    Sir is methionine synthase and homocysteine transferase are same?

  • @TheBestWeddingMusic
    @TheBestWeddingMusic 2 ปีที่แล้ว +3

    Hi. Are these 3 amino acids depend on sulfur ? I can’t eat sulfur foods and B6. I believe my cysteine levels are not in balance but I don’t understand how it all works. I can’t take mo-Zyme forte it cause pain. What reaction is happening there and can you share any links where I can learn more about this? I don’t understand the role of glutamine and glycine. Also the meaning of methionine to cysteine recycling and methionine biosynthesis. Thanks

    • @TheBestWeddingMusic
      @TheBestWeddingMusic 2 ปีที่แล้ว +1

      How selenium plays role in this process to glutathione?

  • @gowthami8968
    @gowthami8968 2 ปีที่แล้ว +2

    Thank you so much sir.
    Very useful videos sir

  • @satishdhawan5408
    @satishdhawan5408 4 ปีที่แล้ว +1

    Very nice explanation sir...tq so much sir

  • @CortexMatrix
    @CortexMatrix 2 ปีที่แล้ว +4

    7:50 sir textbook says Cysteine and à ketobutyrate are formed instead of homoserine.
    Plz clarify

    • @60.praveenkumarp25
      @60.praveenkumarp25 2 ปีที่แล้ว +3

      Same doubt

    • @applestone5812
      @applestone5812 2 ปีที่แล้ว

      @@60.praveenkumarp25 can you suggest a text book for this topic please

    • @60.praveenkumarp25
      @60.praveenkumarp25 2 ปีที่แล้ว

      @@applestone5812 vasudevan

    • @SID-nr4lz
      @SID-nr4lz 7 หลายเดือนก่อน +1

      cysteine and homoserine are formed and from homoserine u get a-ketobutyrate then propionyl then succinyl then glucose

  • @Avinash12988
    @Avinash12988 2 หลายเดือนก่อน

    ❤❤❤

  • @shashanktp6362
    @shashanktp6362 3 ปีที่แล้ว

    Sir you did not mention about glutathione synthesis??

  • @padminisahu153
    @padminisahu153 ปีที่แล้ว

    Sir Homocysteine is essential or non- essential amino acid??

  • @sasankamandi6713
    @sasankamandi6713 2 ปีที่แล้ว

    💥👍

  • @rentoquando5249
    @rentoquando5249 4 ปีที่แล้ว +1

    Sir i take supplements n acetyl cystein en trimethilglisin. You think is safe ? Or you dont recommend this

  • @nitinsur1
    @nitinsur1 ปีที่แล้ว

    How to calculate methionine cysteine ratio in poultry feed

  • @usmanghazanfar3544
    @usmanghazanfar3544 3 ปีที่แล้ว

    Thanks sir for best explanation

  • @drneeraj3619
    @drneeraj3619 6 หลายเดือนก่อน

    Our whole college is dependent on him 😂😂😂😂 #thesaviour

  • @shubhamtornekar3740
    @shubhamtornekar3740 4 ปีที่แล้ว +2

    Sir instead of homoserine can we take Alpha ketobutyrate so that we can add metabolism of leucine and threonine?

  • @user-dp5te6oi9p
    @user-dp5te6oi9p 5 หลายเดือนก่อน

    Sir cysteine dioxygenase likha hnn kyu middle ma

  • @satyapriyaetha7189
    @satyapriyaetha7189 2 ปีที่แล้ว +1

    U r ultimate sir🙏🙏🙏🙏🙏🙏

  • @ujefmakwana5070
    @ujefmakwana5070 2 ปีที่แล้ว

    Pls add subtitles for better experience 😀😀😀...

  • @bilawalsohrani1135
    @bilawalsohrani1135 3 ปีที่แล้ว +1

    sir love hn

  • @MuhammadIbrahim-jf4ix
    @MuhammadIbrahim-jf4ix 4 ปีที่แล้ว

    Sir structure be sath main banao na

  • @03abdulsameerpatel91
    @03abdulsameerpatel91 5 ปีที่แล้ว +6

    Sir upload glycine metabolism

  • @wallflovr
    @wallflovr 3 ปีที่แล้ว +1

    Cystothianine gives cysteine and ketoglutaric acid

  • @subodhrana3214
    @subodhrana3214 3 หลายเดือนก่อน +1

    Good morning sir

  • @alicep.morris8977
    @alicep.morris8977 ปีที่แล้ว

    My son has been diagnosed with this rare sulfur blood born problem. He is in hospital now but the doctors know nothing about it. They are trying to research and problem solve. Is there a doctor out there that has worked with this. My son has had TBI Please help

    • @Rajesh_Jambhulkar
      @Rajesh_Jambhulkar  ปีที่แล้ว +1

      Plz refer to higher centres for follow up and treatment. ( Mumbai, Delhi, Bangalore, chennai) or any metro City near to u.

  • @karishmakhubchandani545
    @karishmakhubchandani545 ปีที่แล้ว +1

    Sir can you please discuss on aromatic amino acid metabolism..

  • @kevinken2576
    @kevinken2576 ปีที่แล้ว +1

    oh

  • @fatimaarshad5802
    @fatimaarshad5802 11 หลายเดือนก่อน

    Great Sir 👍👍

  • @aryasharma3360
    @aryasharma3360 5 ปีที่แล้ว +2

    Sir metabolic acidosis and alkalosis ka video banadijiye

  • @saranyasaa8046
    @saranyasaa8046 ปีที่แล้ว

    Sir , could you please provide pdf note for each topic 🙏

  • @RanaRana-px8jd
    @RanaRana-px8jd 3 ปีที่แล้ว

    8:48 you said here that the cysteine have a sulfur from methionine and the rest of the molecule is from the serine !what is the rest of the molecule you mean homoserine!!!

    • @phyllisbotchway6796
      @phyllisbotchway6796 3 ปีที่แล้ว

      the remaining molecular structure of cyteine i think

  • @anitameena3212
    @anitameena3212 4 ปีที่แล้ว +2

    Sir aap kon si book preferre kar to ho

  • @anitameena3212
    @anitameena3212 4 ปีที่แล้ว

    Replay plz.. sir

  • @60.praveenkumarp25
    @60.praveenkumarp25 2 ปีที่แล้ว +2

    Thank you sir

  • @43hermafathima65
    @43hermafathima65 3 ปีที่แล้ว +1

    Thankyou so much sir❤️

  • @shubhamaggarwal3801
    @shubhamaggarwal3801 3 ปีที่แล้ว +1

    Thank you sir