Structural organization of proteins

Correction- intrachain disulfide bond is there in A- chain, between 6th and 11th aminoacid.
Primary structure
Number and Sequence of AAs, peptide bond
example- insulin
Secondary
Alpha helix, beta sheets, bend, turn ,loop
Bonds- H bonds
example- Carbonic anhydrase, silk fibroin
Tertiary
3D, functional, enzymes
Bonds- hydrophobic interactions, H bonds, electrostatic forces, Van der Waal forces
example- alcohol DH, LDH, MDH, G3P DH, Mb
Quaternary
Two or more subunits together
example- Hb

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[@faizanquraishi4126]

Sir, the intrachain disulfide bond you drew on the b chain of insulin is supposed to be on the A chain.

[@muhammadqaseem-tq1pq]

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[@Rajesh_Jambhulkar]

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[@Rajesh_Jambhulkar]

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[@sudipkantisarkar5947]

Sir, would you please make a tutorial on "Structure function relationship of protein"? Your teaching helped me a lot. Thank you Sir

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[@novaturientmedico9293]

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[@neetbiologybyjunaidalam1217]

a correction doctor, insulin exhibit Quaternary structure...thank u

[@Rajesh_Jambhulkar]

It is a branched polypeptide with active primary structure

[@neetbiologybyjunaidalam1217]

@@Rajesh_Jambhulkar Sir, As Functional Insulin have got Two Peptide chains link together by disulphide linkage..isnt it should be quaternary?
One more thing i want to ask..functional Myoglobin exhibit secondary or tertiary structure..as per my knowledge it got tertiary.
correct me if i am wrong
ur lectures r very amazing..such an awesome teacher u r.
sorry for troubling you sir..just trying to learn some concepts..hope u donot mind

[@Rajesh_Jambhulkar]

Yes, myoglobin exhibit tertiary structure.
Insulin has two polypeptide chains but it does not have quaternary structure. In quaternary structure, the bond involved is primarily non- covalent bond. In insulin two chains are connected by disulfide bond which is a covalent bond.

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It is so helpful

[@muhammadhaseeb6016]

Sir How Can Insulin Have a Primary level of organization. It have two polypeptides having 21 and 30 Amino Acids. It Must Have a Quaternary Structure. Primary Structure is all about Single Polypeptide .Sir Plz Answer?

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👍

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[@reetgupta2627]

Is myoglobin example of tertiary structure?

[@Abdurrahman-c4x]

Yes

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Sir can we write this for long essay 10 mark question?

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Random cool would qualify for which level of protein structure....

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Is that sufficient for MSc level..please reply

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[@tanazanwar4207]

Intrachain disulfide bond between 6th and 11th cysteine residue is in A chain.

[@Rajesh_Jambhulkar]

Yes, correction is there

[@mohammadalam1537]

Sir plzz do case wise Discussion

[@072harleenkaur7]

Sir aapne myoglobin alpha helix mein bhi kaha aa and tertiary structure mein bhi

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Kamal

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best explaination

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[@PoonamRani-hh3oe]

Helpful video

[@proproot]

10:10 Where is angle?For angle to be formed there should be 3 points or 2 lines. Do these C alpha and N denote lines?

[@tanmayjadhav8402]

Sir in some of the reference books it is written that the first and the last peptide bond don't make Hydrogen bonds

[@abhinavkumar6338]

Very helpful

[@karthikeyan.02]

Sir pls add protein &lipid metabolism

[@priyankakamboz8657]

Good

[@m8might]

Why do we call insulin a primary protein even though it has two polypeptide chains?

[@shahabbarkat6005]

Dear Sir,
Are primary and secondary structure proteins are functional protein?
If they are not then what's the reason, kindly elaborate in detail.

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Sir which book you prefer?

[@sanjanarathore7012]

Thank you sir
Sir My question is if secondary structure involve only one polypeptide chain so why beta pleated sheath include in secondary structure while it contain h bond between two polypeptide chain???

[@hayatmurat5460]

sir u meantioned myoglobin and haemoglobin in alpha helix structure
also

[@nikj4436]

Sir 8:54 shouldnt it be A chain(intradisulphide bond)?

[@uokay9428]

Yup vasudevan mein A chain h

[@abhisekmondal7536]

Why primary structure determines 3d structure explain why question please guide sir what to write

[@Firdos7]

Very well explanation sir 👌
But I feel there is little more need about tertiary and quaternary structure.

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What will be the point should be mentioned in written exam for primary structure long question

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Hello

[@neetbiologybyjunaidalam1217]

intramolecular disulphide linkage is present in chain A of insulin, not chain B

[@Rajesh_Jambhulkar]

Yes, correction is there. Thank You

[@amirkhan4625]

Sir g yeh Jo disulfide bond hota hai yeh Sirf tertiary structure main paya jata hai na 🤔 ya primary structure main bhi hota hai?

[@Rajesh_Jambhulkar]

Also In primary structure

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I think you teach best in hindi