Immune Response, Toll Like Receptors (TLR) Pathway - IMGENEX

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  • เผยแพร่เมื่อ 1 ธ.ค. 2024

ความคิดเห็น • 404

  • @Guihlopez
    @Guihlopez 10 ปีที่แล้ว +65

    This video is absolutely amazing. Immunology completely makes sense after watching it. Congratulations to whoever made it.

    • @matthewcurry3565
      @matthewcurry3565 2 ปีที่แล้ว +5

      I think someone poisoned me with literal LSD. What is happening?

  • @killpy12
    @killpy12 4 ปีที่แล้ว +86

    Absolutely horrifying and inscrutable. I love it, thank you

  • @litojonny
    @litojonny 10 ปีที่แล้ว +339

    this is what id imagine what studying immunology high must be like

    • @melthompson9487
      @melthompson9487 9 ปีที่แล้ว +3

      litojonny that is exactly what I was attempting to do and I felt that my needs were tended to. 10/10

    • @mroosie7488
      @mroosie7488 6 ปีที่แล้ว +17

      This IS what studying immunology is like... it's horrific.

    • @matthewludivico1714
      @matthewludivico1714 4 ปีที่แล้ว +4

      While listening to techno music

    • @widyawidya5752
      @widyawidya5752 4 ปีที่แล้ว +2

      Medicine faculty be like

    • @gregorykarimian3813
      @gregorykarimian3813 2 ปีที่แล้ว +1

      LOL

  • @101Phase
    @101Phase 12 ปีที่แล้ว +17

    Believe it or not, I'm currently writing an essay on Toll-like receptor signalling for a coursework and this was the most accessible summary I've found so far. Excellent work!

  • @Hellos.5
    @Hellos.5 9 หลายเดือนก่อน +4

    I can only imagine a game designer and a doctor collaborating on this 😂. It’s a wild ride.

  • @Airhockeylirare
    @Airhockeylirare 11 ปีที่แล้ว +417

    So this is what happens when microbiologists take LSD...

    • @joeshellhammer
      @joeshellhammer 9 ปีที่แล้ว +12

      I thought the very same thing when I first watched it, even though I really liked it. But, wow, what an imagination! Pretty impressive. I thought it would have been appropriate to have this video set to "Lucy in the Sky with Diamonds".

    • @prasadbotheju5682
      @prasadbotheju5682 7 ปีที่แล้ว +1

      I'm researching relieving sarcoidosis condition naturally and found a great website at Remission Crusher Tactic (google it if you are interested)

    • @innate-videos
      @innate-videos 5 ปีที่แล้ว

      hahahahahahahahah

    • @rittenbrake1613
      @rittenbrake1613 5 ปีที่แล้ว

      Nina Borodinskaja 😂😂😂😂😂😂👍🏻

    • @giannis101
      @giannis101 4 ปีที่แล้ว

      Hahaha

  • @rickyroko1
    @rickyroko1 8 ปีที่แล้ว +91

    This is the greatest ANIMATION i've ever seen in immunology! lots of love

    • @qingzheng7485
      @qingzheng7485 4 ปีที่แล้ว

      me too

    • @kingsleyuduehikingsleyudue1494
      @kingsleyuduehikingsleyudue1494 4 ปีที่แล้ว

      I want to thank Dr ehime herbs for the help he has rendered to me by getting Rid
      of my (HIV). I was Diagnosed in July 2018 but after the Usage of Dr ehime herbs
      Herbal Medicine, I was cured from (HIV) and the virus was completely gone
      from my body. The Symptoms of the (HIV) Virus is completely Gone.. So
      anyone who is having the virus should contact Dr ehime herbs to give you the
      herbal medicine to cure yourself. HERPES, You can contact on Instagram @dr_ehime_cure2 or contact WhatsApp number (+2348144387765) or email (drehimecure325@gmail.com)
      He cures all this illness,.
      1 cancer cure
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      10 prostate enlargement
      11 Hepatitis B
      12 Dysfunction...

  • @yeshitellaaleme4419
    @yeshitellaaleme4419 3 ปีที่แล้ว +6

    I watched this 6 years ago and I wanted to watch it again then my mom put out a TH-cam video and it popped up I'm crying tears of joy!!

  • @leticiacuellar6474
    @leticiacuellar6474 7 ปีที่แล้ว +10

    Kudos to the producers for making this TLR series funky fun!

  • @juliaskripka-serry2537
    @juliaskripka-serry2537 9 ปีที่แล้ว +93

    Welllll peeing my pants laughing is definitely not the outcome I was expecting when I youtubed TLR videos today

  • @mindimpulse47
    @mindimpulse47 10 ปีที่แล้ว +77

    it would have been bestt if there was commentary too .. for explaining the video

    • @sardarali2025
      @sardarali2025 7 ปีที่แล้ว +1

      exactly

    • @nancyab9862
      @nancyab9862 6 ปีที่แล้ว

      Exactly👌🏻👌🏻👌🏻

    • @jeherulislam6903
      @jeherulislam6903 4 ปีที่แล้ว +5

      This video seems to be targeted to one who already knows the whole process but feels jumbled and would like animated description. Last time I watched i didn't get a things but now I can see why i didn't.
      So proper description is better to target larger audience

    • @rakshith1994
      @rakshith1994 4 ปีที่แล้ว

      Read in textbook and come back and watch. This is a good video to a clear picture. PS: I read Veterinary Immunology by Ian Tizard 10th Ed before watching this. And it gave a super good clarity. You can choose your own books too.

  • @dr.salmanriaz1468
    @dr.salmanriaz1468 9 ปีที่แล้ว +26

    what can u expect more than this?...
    lovely...thousands of heart loving kisses to the one who created

    • @rashaessam9426
      @rashaessam9426 5 ปีที่แล้ว +1

      Dr.Butterscotch certainly great effort

    • @kingsleyuduehikingsleyudue1494
      @kingsleyuduehikingsleyudue1494 4 ปีที่แล้ว

      I want to thank Dr ehime herbs for the help he has rendered to me by getting Rid
      of my (HIV). I was Diagnosed in July 2018 but after the Usage of Dr ehime herbs
      Herbal Medicine, I was cured from (HIV) and the virus was completely gone
      from my body. The Symptoms of the (HIV) Virus is completely Gone.. So
      anyone who is having the virus should contact Dr ehime herbs to give you the
      herbal medicine to cure yourself. HERPES, You can contact on Instagram @dr_ehime_cure2 or contact WhatsApp number (+2348144387765) or email (drehimecure325@gmail.com)
      He cures all this illness,.
      1 cancer cure
      2 diabetes cure
      3 ringing ear
      4 herpes cure
      5 warts cure
      6 HPV cure
      7 Hiv
      8 get your ex back
      9 pregnancy herbal medicine
      10 prostate enlargement
      11 Hepatitis B
      12 Dysfunction...

  • @ita14
    @ita14 12 ปีที่แล้ว +1

    B7 molecules are B7.1 (CD80) and B7.2 (CD86). They both bind CD28 to sustain T cell activation.

  • @HassanKhan-sx1nt
    @HassanKhan-sx1nt ปีที่แล้ว

    content like this derived people's on youtube to clear concept such videos make study very easy so there is no excuse for no learning

  • @caslandry2847
    @caslandry2847 5 ปีที่แล้ว +9

    This is kinds how it feels when I study for my immunology final after a few too many edibles, and maybe some acid.

    • @kingsleyuduehikingsleyudue1494
      @kingsleyuduehikingsleyudue1494 4 ปีที่แล้ว

      I want to thank Dr ehime herbs for the help he has rendered to me by getting Rid
      of my (HIV). I was Diagnosed in July 2018 but after the Usage of Dr ehime herbs
      Herbal Medicine, I was cured from (HIV) and the virus was completely gone
      from my body. The Symptoms of the (HIV) Virus is completely Gone.. So
      anyone who is having the virus should contact Dr ehime herbs to give you the
      herbal medicine to cure yourself. HERPES, You can contact on Instagram @dr_ehime_cure2 or contact WhatsApp number (+2348144387765) or email (drehimecure325@gmail.com)
      He cures all this illness,.
      1 cancer cure
      2 diabetes cure
      3 ringing ear
      4 herpes cure
      5 warts cure
      6 HPV cure
      7 Hiv
      8 get your ex back
      9 pregnancy herbal medicine
      10 prostate enlargement
      11 Hepatitis B
      12 Dysfunction...

  • @neerajpatil3735
    @neerajpatil3735 10 ปีที่แล้ว +2

    Hey! You have uploaded a really nice video. But changes should be made in the names of all component cells and proteins. One can not see properly the names in lower resolutions.

  • @russelmiller7311
    @russelmiller7311 7 ปีที่แล้ว

    vivid explanation on the topic. Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.

  • @rtpcr3969
    @rtpcr3969 6 ปีที่แล้ว +21

    imagine being a molecule

  • @username7445
    @username7445 3 ปีที่แล้ว

    The cast is very well chosen! Congratulations😂

  • @Mai0211
    @Mai0211 11 ปีที่แล้ว +3

    love the animation! makes it much more fun to watch, especially for someone with a short attention span like me who's trying to study. But you should have someone explaining each process instead of music, that would be much better :D someone with a good cartoon voice.

  • @wellyd44
    @wellyd44 12 ปีที่แล้ว

    Yes CD80 and CD86 are B7 molecules expressed by the APC upon TLR activation. CD80 is B7.1 and CD86 is B7.2. The B7 nomenclature is old whereas the CD nomenclature is more modern.

  • @edwardhaughney9665
    @edwardhaughney9665 3 ปีที่แล้ว

    Rather stunning presentation. Pictures are more powerful than words. Keep up the good work. Don't usually care for music accompaniment but this seems to work.

  • @nechamarakow3922
    @nechamarakow3922 9 ปีที่แล้ว

    the best way to study! its really a difficult war going inside our bodies.

  • @MrTimothy250
    @MrTimothy250 12 ปีที่แล้ว

    Well, in fact, there is two types of B7 proteins. B7-1, which is CD80, and B7-2, also nammed CD86. Both can fix CD28 or CTLA-4, respectively stimulating or inhibiting the lymphocyte T CD4+ cell.

  • @areanaangel8964
    @areanaangel8964 6 ปีที่แล้ว +26

    the music was nice tho. i was dancing in my room. lol

  • @sophiabang7868
    @sophiabang7868 4 ปีที่แล้ว

    When you leave no room in your budget for sound lol. Honestly though great video for visualizing TLR system and MHC II antigen presentation. Makes things make more sense as you read.

  • @Prettyspeck
    @Prettyspeck 11 ปีที่แล้ว +2

    Wish everything could be explained in this way. zthis is Amazing

  • @aishabhat2358
    @aishabhat2358 6 ปีที่แล้ว +4

    This is toooo cute,never seen anything so interesting and creative related to my studies.
    Thank you so much for this animation❤

  • @Peter7beardmaster
    @Peter7beardmaster 11 ปีที่แล้ว

    this is exactly how Kuby's describes the process..you just won a like and subscription, thanks a lot

  • @kakhangchungpanmei8205
    @kakhangchungpanmei8205 11 ปีที่แล้ว

    So helpful. wasnt sure about PPR an TLR, now i know , ur website is really helpfull. kip up the good work.

  • @vaidyakannadiga1005
    @vaidyakannadiga1005 6 ปีที่แล้ว

    Kindly give background lecture ,that might helpful for exact and detailed understanding

  • @stemked
    @stemked 11 ปีที่แล้ว +1

    Very nice. I'm going to use this video in my Immunology class.

  • @Saul_GC
    @Saul_GC 13 ปีที่แล้ว

    there are soooo many things other than what appears here that i must learn, may god have mercy on my soul, and on your souls if you are/will be in this situation

  • @brazilian777able
    @brazilian777able 12 ปีที่แล้ว

    This is a very creative ingenious video. Excellent!!! I love the end with the showing of the cast. LOL

  • @savi263
    @savi263 4 ปีที่แล้ว

    Superb animation to understand the TLR biology! Thanks

  • @habibehk
    @habibehk 10 หลายเดือนก่อน

    Saved it, and sent the link to my kids- Cool, fun and creative animation! If you can, please share the link(s) to your other work(s) in the reply to comment section.

  • @kandrew5v5
    @kandrew5v5  13 ปีที่แล้ว +3

    @Mjhond Thanks, I appreciate it! We are working on more videos as we speak.

  • @DrMcGunner
    @DrMcGunner 7 ปีที่แล้ว +1

    Great video! I am a visual learner so it really helped me to put faces with all these things.

  • @marvahkhalid5060
    @marvahkhalid5060 3 ปีที่แล้ว

    wow this is soo amazing!! thankyou for your efforts in creating this

  • @bangtanbeau2131
    @bangtanbeau2131 8 ปีที่แล้ว

    VERY GOOD ANIMATION. Thankyou! It helped me a lot!

  • @malikzahid6848
    @malikzahid6848 4 ปีที่แล้ว

    Excellent sir but name of component and cells are not clear.

  • @walidsong2255
    @walidsong2255 4 ปีที่แล้ว

    Please explain the work of the enzyme 5 alpha reductase in changing the male hormone, and where it is produced. Thank you.

  • @kandrew5v5
    @kandrew5v5  13 ปีที่แล้ว +2

    Also check out Imgenex's new apoptosis detection tool called pSIVA

  • @dezafeatle
    @dezafeatle 12 ปีที่แล้ว +2

    Very helpful video. Helped me understand my immuno-biology class a lot better.

  • @jaquelinemanuel5716
    @jaquelinemanuel5716 11 ปีที่แล้ว +1

    cute, entertaining, and interesting! I hope more videos on immunology and other topics in med will come soon! Thanks!

  • @z5612y73
    @z5612y73 12 ปีที่แล้ว

    PERFECT video ! I like this!
    But...uhhhh....I think most important cytikine for inhibition are IL-10 and TGF-beta in Treg.
    IL-2 is a cytokine for activation (IL-2 is so called T cell growth factor).
    the function of IFN-gamma is that maintain cellular immunity, and clear intracellular pathogen. It is most important Th1 cytokine.
    there are some people indicate that IL-10 is Th2 cytokine. too.
    If I've made any mistake, I'm sorry.

  • @thatblindgamer726
    @thatblindgamer726 5 ปีที่แล้ว +3

    This looks like an HD version of Rhapsitte Street Kids Believe In Santa

  •  11 ปีที่แล้ว

    interesting animations you got there.
    Keep up the good work!

  • @zeeto_k
    @zeeto_k 4 ปีที่แล้ว

    this video is more helpful more than my prof.

  • @brooklyn5466
    @brooklyn5466 ปีที่แล้ว

    So if you give the body the right foods it's able to have the stuff needed to do it job.

  • @capriccioso35
    @capriccioso35 12 ปีที่แล้ว

    @gerbilinatube CD 80 is another name for B7 and yes it links with CD28 as a costimulator for T cell ( in this case, CD4 , helper T cells) activation

  • @imegatrone
    @imegatrone 13 ปีที่แล้ว

    Nice Video That You Share , So Very Nice Thanks You . In invertebrates it is the sole mechanism of defense against pathogens but in higher vertebrates constitutes the first line of defense

  • @ashwinishinde64875
    @ashwinishinde64875 4 ปีที่แล้ว

    Please upload more videos ..... This is so easier to understand everyone ..... I have never see like this animation 😂🤦😍😍

  • @investigacaopsicologiaavan8256
    @investigacaopsicologiaavan8256 3 ปีที่แล้ว

    Hi IMGENEX, can I download your video for my self? Thank you

  • @infovitindia
    @infovitindia 9 ปีที่แล้ว +1

    Hi guys....Don't u think the quality, look n feel and overall composition is -sorry to say- is quite low in comparison with the earlier ones ??...it could hv been better.......

    • @jkegan6037
      @jkegan6037 8 ปีที่แล้ว

      +Biswa bhanu As a graphic designer, this is a little painful to watch. But if it helps people learn, then it has my approval.

  • @MrPawan05
    @MrPawan05 6 ปีที่แล้ว

    Holy shit! We should have nanoscopic cams installed in our body. That would make great reality show of all time.

  • @hgsnk333
    @hgsnk333 11 ปีที่แล้ว

    Please (and thank you) make one for CLRs, RLRs and NLRs!!!

  • @_SankalpaBhusal
    @_SankalpaBhusal 5 ปีที่แล้ว

    It was like a complete review for me!!! Great job...🙌✌🙌

  • @anujapatil2902
    @anujapatil2902 7 ปีที่แล้ว

    very thoughtful, thanks, guys for uploading this video!

  • @kandrew5v5
    @kandrew5v5  13 ปีที่แล้ว +2

    @gutrp Thats Great! If I only I had videos like this through school, it would have made immunology a lot easier to digest!

  • @esse318
    @esse318 13 ปีที่แล้ว

    the presentation is clear and fun
    but it's a little complicated for me to understand the codes of molecules

  • @knucklescapricorn31
    @knucklescapricorn31 13 ปีที่แล้ว

    Oh my gosh, this is great! Why the hell does this vid only have around 2000 views while other sh!t ones have like over 100,000???

  • @karleffertz
    @karleffertz 12 ปีที่แล้ว

    Great video!! when are 2 and 3 coming out??

  • @azeemnaeem6720
    @azeemnaeem6720 4 ปีที่แล้ว +1

    Lovely inspiration for immunology

  • @esra11102010
    @esra11102010 11 ปีที่แล้ว

    This is amazing. Keep up with the good work, I like them all

  • @raspberry996
    @raspberry996 12 ปีที่แล้ว +2

    When I first read the title I thought it said 'Troll Like Receptors'

  • @leonstellander8602
    @leonstellander8602 4 ปีที่แล้ว

    I will never forget this

  • @marekfutryna3804
    @marekfutryna3804 2 ปีที่แล้ว

    I do not know what stuff was taken by the author but i want it too

  • @MadrassaDzOubahMed
    @MadrassaDzOubahMed 6 ปีที่แล้ว

    Hi ...thank you very much for your videos ..
    could you tell me please the name of the program that can make that animation style ... thanks again

  • @rrintan9140
    @rrintan9140 6 ปีที่แล้ว

    W000WWW omg. thank you so much for creating this creative animation! this will definitely help me so much to pass the exam :)

  • @RaviSingh-yz9tx
    @RaviSingh-yz9tx 7 ปีที่แล้ว

    Awesome video with excellent presentation

  • @Racheal700
    @Racheal700 6 ปีที่แล้ว

    This is awesomeeee....things like this make it so much easier

  • @drsomto007
    @drsomto007 ปีที่แล้ว

    I thought it's supposed to be CD4 on the T cell, please explain

  • @uzmakhan9264
    @uzmakhan9264 6 ปีที่แล้ว

    Truly it made my topic easy to remember !!THANKS😊

  • @britneythao
    @britneythao 12 ปีที่แล้ว

    Very nice and well made animation. However, there are some parts I don't understand. For example, I don't know why the dude CD80/CD86 at 2:31 got stuck at the cell membrane. LOL. This might be for higher level in immunology. It would be nicer if there is explanation going along with the video.

  • @aleenajamil7495
    @aleenajamil7495 10 ปีที่แล้ว

    Really good explanation and animations!

  • @vionagunawan5938
    @vionagunawan5938 ปีที่แล้ว

    Wow this is so cool, and I can understand it immediately

  • @tropicantei5550
    @tropicantei5550 5 ปีที่แล้ว

    WAAAAW THANK YOU. YOU JUST SAVED MY FINALS x))))

  • @Ozinco
    @Ozinco 10 ปีที่แล้ว

    Genuinely the best signalling animation I have seen to date, bravo sir!

  • @Electroblade360
    @Electroblade360 4 ปีที่แล้ว +1

    Why Did The Pathogen Killed Itself This Means The Pathogen Hates Itself

  • @kotosqoposrly
    @kotosqoposrly 11 หลายเดือนก่อน

    I gotta give it to you that such a complex subject being presented in this childish way, with horrible sound effects, does work because I understood what was going on here.

  • @melvindsouza834
    @melvindsouza834 8 ปีที่แล้ว +2

    if there were subtitles I would understand...I don't come from a science background to understand anything.

    • @mroosie7488
      @mroosie7488 6 ปีที่แล้ว

      I agree, it took me quite a while to figure out what was occuring.

  • @pfeliciano4062
    @pfeliciano4062 4 ปีที่แล้ว

    These creatures look creepy but after after reading the section this makes it stick

  • @marcleblanc3602
    @marcleblanc3602 9 ปีที่แล้ว

    Those monsters dont really exist, what chemical reactions drive them?

  • @MeganWhamGMfan
    @MeganWhamGMfan 4 ปีที่แล้ว

    Germs think were their home
    But cells said no

  • @Salma_Mulla
    @Salma_Mulla 6 หลายเดือนก่อน

    this video is better 10x than my teacher explanation

  • @fenotipobombay
    @fenotipobombay 12 ปีที่แล้ว

    what is the function of cd80/cd86? and why the microbe is destroyed once he gets (endocytosis?) inside the cell? what is the mechanism that lead to the production of the antigens linked to mhc II?

  • @SimonCU
    @SimonCU 12 ปีที่แล้ว

    I think the letters needs to be larger in font because its difficult to see clearly. Or someone needs to add voice into it.

  • @kandrew5v5
    @kandrew5v5  13 ปีที่แล้ว +1

    @PastelitaVelys Do you mean our TLR book? Or another resource? Thanks!

  • @sxyngel
    @sxyngel 12 ปีที่แล้ว

    whats an ikb???? would help alot if you list the full names of all the abbreviations

  • @kanzu4225
    @kanzu4225 3 ปีที่แล้ว

    El vídeo es interesante para saber de las células y bacterias de como entran y las células se defienden mostrando como y que se usa para la defensa de las bacterias

  • @NLNikoleta
    @NLNikoleta 12 ปีที่แล้ว

    i am using anti-TNF inhibitors and i like your video so much!

  • @mesentsev
    @mesentsev 11 ปีที่แล้ว

    It is hard to read whatever was in this video. The font is too small

  • @Toughtriples
    @Toughtriples 7 ปีที่แล้ว

    its amazing keep uploading such type of videos

  • @bharathraj5862
    @bharathraj5862 5 ปีที่แล้ว

    Great work!!
    Easy to understand and thank you.

  • @ashithak6268
    @ashithak6268 4 ปีที่แล้ว

    Excellent. The video says it all....

  • @guybrown9422
    @guybrown9422 8 ปีที่แล้ว

    im a bit confused, does Th1 differentiation require both IL-12 AND IFNy?

    • @ileikdonuts
      @ileikdonuts 8 ปีที่แล้ว

      i read an article and i think IL12 (more than IFNy) is needed to help stimulate the transcription factors for Th1 development
      if that helps haha

    • @guybrown9422
      @guybrown9422 8 ปีที่แล้ว

      Cool thanks it did actually! and that would be STAT4. I think IFNy must just be the effector cytokine

  • @marleneiradukunda4618
    @marleneiradukunda4618 10 ปีที่แล้ว

    Great video!
    It's so easy to understand :)

  • @priyankagorai6549
    @priyankagorai6549 2 ปีที่แล้ว

    This is absolutely amazing

  • @Pilelili
    @Pilelili 6 ปีที่แล้ว +1

    Interesting, you made it very interesting!
    Thanks a lot for sharing your knowledge in such a smart fun way!